[ { "uniprot_canonical_ac": "Q9W2S1-1", "uniprot_id": "Q9W2S1_DROME", "mass": 58184.0, "length": 530, "protein_name": "Transport and golgi organization 5, isoform A; Transport and golgi organization 5, isoform C; Transport and golgi organization 5, isoform D; Transport and golgi organization 5, isoform E; Transport and golgi organization 5, isoform F", "gene_name": "Tango5", "organism": "Fruit fly", "refseq_name": "transport and golgi organization 5, isoform D", "refseq_ac": "NP_001162716", "gene_names_uniprotkb": "Tango5; CG1534; CG32675; Dmel\\CG32675; Dmel_CG32675; TANGO5; vmp1", "gene_names_refseq": "CG1534; CG32675; Dmel\\CG32675; TANGO5; Tango5; vmp1", "protein_names_uniprotkb": "Transport and golgi organization 5, isoform A; Transport and golgi organization 5, isoform C; Transport and golgi organization 5, isoform D; Transport and golgi organization 5, isoform E; Transport and golgi organization 5, isoform F", "protein_names_refseq": "CG32675-PD; Tango5-PD; transport and golgi organization 5, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32675)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W2S0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0009306 protein secretion;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2S2-1", "uniprot_id": "Q9W2S2_DROME", "mass": 14392.0, "length": 121, "protein_name": "Autophagy-related 8a, isoform A", "gene_name": "Atg8a", "organism": "Fruit fly", "refseq_name": "Autophagy-related 8a, isoform A", "refseq_ac": "NP_727447", "gene_names_uniprotkb": "Atg8a; ATG8A; ATG8a; ATG8; Atg-8a; Atg8A; Atg8alpha; Atg8; BcDNA:LD05816; CG1534; CG32672; DmAtg8a; Dmel\\CG32672; Dmel_CG32672; DrAtg8a; LC3; agt8a; atg8A; atg8a; atg8; dAtg8a; dAtg8", "gene_names_refseq": "ATG8/LC3; ATG8A; ATG8a; ATG8; Atg-8a; Atg8/LC3; Atg8A; Atg8alpha; Atg8a; Atg8; BcDNA:LD05816; CG1534; CG32672; DmAtg8a; Dmel\\CG32672; DrAtg8a; LC3/Atg8; LC3; agt8a; atg8A; atg8a; atg8; dAtg8a; dAtg8", "protein_names_uniprotkb": "Autophagy-related 8a, isoform A", "protein_names_refseq": "Atg8a-PA; Autophagy-related 8a, isoform A; Autophagy-specific gene 8a; CG32672-PA; autophagy-related 8 protein; autophagy-related 8a", "tax_id": 7227, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (dme:Dmel_CG32672); (R-DME-1632852); (R-DME-8854214)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40066832", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding;GO:0050811 GABA receptor binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0012505 endomembrane system;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0044754 autolysosome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0006909 phagocytosis;GO:0016236 macroautophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W2S2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2U2-1", "uniprot_id": "Q9W2U2_DROME", "mass": 41333.0, "length": 377, "protein_name": "Disease resistance R13L4/SHOC-2-like LRR domain-containing protein", "gene_name": "CT7080", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001259412", "gene_names_uniprotkb": "CT7080; BcDNA:RH29237; CG2143; CG2892; CG32687; CT6984; Cg32687; Dmel\\CG32687; Dmel_CG32687", "gene_names_refseq": "BcDNA:RH29237; CG2143; CG2892; CG32687; CT6984; CT7080; Cg32687; Dmel\\CG32687", "protein_names_uniprotkb": "Disease resistance R13L4/SHOC-2-like LRR domain-containing protein", "protein_names_refseq": "CG32687-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32687)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2V8-1", "uniprot_id": "Q9W2V8_DROME", "mass": 39915.0, "length": 351, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG2898", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572623", "gene_names_uniprotkb": "Dmel\\CG2898; CG2898; Dmel_CG2898", "gene_names_refseq": "CG2898; Dmel\\CG2898", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG2898-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2898)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2V8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2W2-1", "uniprot_id": "Q9W2W2_DROME", "mass": 41341.0, "length": 357, "protein_name": "Calponin-homology (CH) domain-containing protein", "gene_name": "Dmel\\CG15306", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001259403", "gene_names_uniprotkb": "Dmel\\CG15306; CG15306; Dmel_CG15306", "gene_names_refseq": "CG15306; Dmel\\CG15306", "protein_names_uniprotkb": "Calponin-homology (CH) domain-containing protein", "protein_names_refseq": "CG15306-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15306)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0051233 spindle midzone;GO:0005815 microtubule organizing center;GO:0005881 cytoplasmic microtubule;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0051225 spindle assembly;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2W2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2X6-1", "uniprot_id": "Q9W2X6_DROME", "mass": 16728.0, "length": 157, "protein_name": "ATP synthase F(1) complex subunit delta, mitochondrial", "gene_name": "ATPsyndelta", "organism": "Fruit fly", "refseq_name": "ATP synthase, delta subunit, isoform B", "refseq_ac": "NP_001259397", "gene_names_uniprotkb": "ATPsyndelta; ATP5D; ATPD; CG2968; Dmel\\CG2968; Dmel_CG2968; anon-WO03040301.109; anon-WO03040301.110; l (1) G0230; l(1)G0230", "gene_names_refseq": "ATP5D; ATPD; ATPsyndelta; CG2968; Dmel\\CG2968; anon-WO03040301.109; anon-WO03040301.110; l (1) G0230; l(1)G0230", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit delta, mitochondrial; ATP synthase F1 subunit delta; F-ATPase delta subunit", "protein_names_refseq": "ATP synthase delta chain; ATP synthase, delta subunit, isoform B; ATPsyndelta-PB; CG2968-PB; F0/F1 ATP synthase delta; lethal (1) G0230", "tax_id": 7227, "disease": "colitis (Disease Ontology:DOID:0060180); mitochondrial complex V (ATP synthase) deficiency nuclear type 5 (Disease Ontology:DOID:0070463); Alzheimer's disease (Disease Ontology:DOID:10652); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG2968); (R-DME-163210); (R-DME-8949613)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2X6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W314-1", "uniprot_id": "Q9W314_DROME", "mass": 43649.0, "length": 397, "protein_name": "3.4.21.-; Ser7", "gene_name": "Ser7", "organism": "Fruit fly", "refseq_name": "Ser7", "refseq_ac": "NP_572582", "gene_names_uniprotkb": "Ser7; CG2045; Dmel\\CG2045; Dmel_CG2045; SP#2; SP2; SP3; c-SP3; cSP3", "gene_names_refseq": "CG2045; Dmel\\CG2045; SP#2; SP2; SP3; Ser7; c-SP3; cSP3", "protein_names_uniprotkb": "3.4.21.-; Ser7", "protein_names_refseq": "CG2045-PA; Ser7-PA; Ser7; serine protease 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2045)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0017171 serine hydrolase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W314-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W316-1", "uniprot_id": "Q9W316_DROME", "mass": 37182.0, "length": 327, "protein_name": "4.2.1.-; 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CG10970; Dmel\\CG10970; Dmel_CG10970", "gene_names_refseq": "BcDNA:HL08157; CG10970; Dmel\\CG10970", "protein_names_uniprotkb": "Acylphosphatase-like domain-containing protein", "protein_names_refseq": "CG10970-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10970)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3A0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3B3-1", "uniprot_id": "Q9W3B3_DROME", "mass": 30895.0, "length": 277, "protein_name": "Uroporphyrinogen-III synthase", "gene_name": "Uros1", "organism": "Fruit fly", "refseq_name": "uroporphyrinogen III synthase 1, isoform B", "refseq_ac": "NP_001259362", "gene_names_uniprotkb": "Uros1; CG1885; Dmel\\CG1885; Dmel_CG1885", "gene_names_refseq": "CG1885; Dmel\\CG1885; Uros1", "protein_names_uniprotkb": "Uroporphyrinogen-III synthase; 4.2.1.75; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase", "protein_names_refseq": "CG1885-PB; Uros1-PB; uroporphyrinogen III synthase 1, isoform B", "tax_id": 7227, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271)", "pathway": " (dme:Dmel_CG1885); (R-DME-189451)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.75", "go_molecular_function": "GO:0004852 uroporphyrinogen-III synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0006780 uroporphyrinogen III biosynthetic process;GO:0006785 heme B biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3B3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3C8-1", "uniprot_id": "Q9W3C8_DROME", "mass": 28804.0, "length": 250, "protein_name": "4.2.1.1; Carbonic anhydrase 3, isoform A; Carbonic anhydrase 3, isoform B; Carbonic anhydrase 3, isoform C; Carbonic anhydrase 3, isoform D; Carbonic anhydrase 3, isoform E", "gene_name": "CAH3", "organism": "Fruit fly", "refseq_name": "carbonic anhydrase 3, isoform B", "refseq_ac": "NP_001259349", "gene_names_uniprotkb": "CAH3; CG11284; CG11285; Dmel\\CG11284; Dmel_CG11284", "gene_names_refseq": "CAH3; CG11284; CG11285; Dmel\\CG11284", "protein_names_uniprotkb": "4.2.1.1; Carbonic anhydrase 3, isoform A; Carbonic anhydrase 3, isoform B; Carbonic anhydrase 3, isoform C; Carbonic anhydrase 3, isoform D; Carbonic anhydrase 3, isoform E", "protein_names_refseq": "CAH3-PB; CG11284-PB; carbonic anhydrase 3, isoform B", "tax_id": 7227, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Graves ophthalmopathy (Disease Ontology:DOID:0081120); primary biliary cholangitis (Disease Ontology:DOID:12236); lesion of sciatic nerve (Disease Ontology:DOID:12528); Sjogren's syndrome (Disease Ontology:DOID:12894); viral hepatitis (Disease Ontology:DOID:1884); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG11284)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3F1-1", "uniprot_id": "Q9W3F1_DROME", "mass": 31013.0, "length": 273, "protein_name": "Sepiapterin reductase", "gene_name": "144701_at", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572481", "gene_names_uniprotkb": "144701_at; CG12116; Dmel\\CG12116; Dmel_CG12116", "gene_names_refseq": "144701_at; CG12116; Dmel\\CG12116", "protein_names_uniprotkb": "Sepiapterin reductase", "protein_names_refseq": "CG12116-PA; uncharacterized protein", "tax_id": 7227, "disease": "sepiapterin reductase deficiency (Disease Ontology:DOID:0111168); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543)", "pathway": " (dme:Dmel_CG12116)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004757 sepiapterin reductase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006729 tetrahydrobiopterin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3H0-1", "uniprot_id": "Q9W3H0_DROME", "mass": 117927.0, "length": 1056, "protein_name": "Atrial natriuretic peptide-converting enzyme", "gene_name": "SPH198", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001245577", "gene_names_uniprotkb": "SPH198; CG1632; Dmel\\CG1632; Dmel_CG1632", "gene_names_refseq": "CG1632; Dmel\\CG1632; SPH198", "protein_names_uniprotkb": "Atrial natriuretic peptide-converting enzyme", "protein_names_refseq": "CG1632-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1632)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3H0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3H4-1", "uniprot_id": "Q9W3H4_DROME", "mass": 26513.0, "length": 247, "protein_name": "1.1.1.184; Sniffer, isoform A; Sniffer, isoform B", "gene_name": "sni", "organism": "Fruit fly", "refseq_name": "sniffer, isoform B", "refseq_ac": "NP_001285012", "gene_names_uniprotkb": "sni; CG10964; Dmel\\CG10964; Dmel_CG10964; SNI; Sni; anon-WO03040301.183", "gene_names_refseq": "CG10964; Dmel\\CG10964; SNI; Sni; anon-WO03040301.183; sni", "protein_names_uniprotkb": "1.1.1.184; Sniffer, isoform A; Sniffer, isoform B", "protein_names_refseq": "CG10964-PB; sni-PB; sniffer, isoform B; sniffer", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG10964)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15364585;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0004090 carbonyl reductase (NADPH) activity;GO:0160241 cardiolipin dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W3H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3I6-1", "uniprot_id": "Q9W3I6_DROME", "mass": 36803.0, "length": 323, "protein_name": "E3 ubiquitin-protein ligase MARCHF5", "gene_name": "Dmel\\CG10761", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572456", "gene_names_uniprotkb": "Dmel\\CG10761; CG10761; Dmel_CG10761", "gene_names_refseq": "CG10761; Dmel\\CG10761", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; RING-type E3 ubiquitin transferase MARCHF5", "protein_names_refseq": "CG10761-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10761)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3I8-1", "uniprot_id": "Q9W3I8_DROME", "mass": 24603.0, "length": 217, "protein_name": "phospholipase A2", "gene_name": "GIIIspla2", "organism": "Fruit fly", "refseq_name": "phospholipase A2 group III, isoform C", "refseq_ac": "NP_001285008", "gene_names_uniprotkb": "GIIIspla2; 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Cypher, isoform C", "gene_name": "cyr", "organism": "Fruit fly", "refseq_name": "cypher, isoform C", "refseq_ac": "NP_001285004", "gene_names_uniprotkb": "cyr; CG15335; CG15338; Dmel\\CG15335; Dmel_CG15335", "gene_names_refseq": "CG15335; CG15338; Dmel\\CG15335; cyr", "protein_names_uniprotkb": "Cypher, isoform B; Cypher, isoform C", "protein_names_refseq": "CG15335-PC; cypher, isoform C; cyr-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15335)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3K2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3M1-1", "uniprot_id": "Q9W3M1_DROME", "mass": 21016.0, "length": 181, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG15330", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572430", "gene_names_uniprotkb": "Dmel\\CG15330; CG15330; Dmel_CG15330", "gene_names_refseq": "CG15330; Dmel\\CG15330", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG15330-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15330)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3Q8-1", "uniprot_id": "Q9W3Q8_DROME", "mass": 6385.0, "length": 65, "protein_name": "Uncharacterized protein", "gene_name": "BcDNA:RH67809", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_652531", "gene_names_uniprotkb": "BcDNA:RH67809; CG11368; Dmel\\CG11368; Dmel_CG11368", "gene_names_refseq": "BcDNA:RH67809; CG11368; Dmel\\CG11368", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG11368-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11368)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3Q8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3R8-1", "uniprot_id": "Q9W3R8_DROME", "mass": 35391.0, "length": 308, "protein_name": "sn-1-specific diacylglycerol lipase ABHD11", "gene_name": "Dmel\\CG2059", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001188553", "gene_names_uniprotkb": "Dmel\\CG2059; CG2059; Dmel_CG2059", "gene_names_refseq": "CG2059; Dmel\\CG2059", "protein_names_uniprotkb": "sn-1-specific diacylglycerol lipase ABHD11; 3.1.1.116; Alpha/beta hydrolase domain-containing protein 11", "protein_names_refseq": "CG2059-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2059)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.116", "go_molecular_function": "GO:0052689 carboxylic ester hydrolase activity;GO:0017171 serine hydrolase activity;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3R8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3V9-1", "uniprot_id": "Q9W3V9_DROME", "mass": 64727.0, "length": 601, "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "Nf-YC", "organism": "Fruit fly", "refseq_name": "nuclear factor Y-box C", "refseq_ac": "NP_572354", "gene_names_uniprotkb": "Nf-YC; CG3075; Dmel\\CG3075; Dmel_CG3075; NF-YC; NFYC; Nf-yc; dNF-YC; nf-yc", "gene_names_refseq": "CG3075; Dmel\\CG3075; NF-YC; NFYC; Nf-YC; Nf-yc; dNF-YC; nf-yc", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit gamma; CAAT box DNA-binding protein subunit C; Nuclear transcription factor Y subunit C", "protein_names_refseq": "CG3075-PA; NF-YC-like; Nf-YC-PA; nuclear factor Y-box C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3075)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;33925313;40245499", "class_list": "", "function": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9W3V9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3W6-1", "uniprot_id": "Q9W3W6_DROME", "mass": 371375.0, "length": 3313, "protein_name": "Small ovary, isoform A; Small ovary, isoform B; Small ovary, isoform C", "gene_name": "sov", "organism": "Fruit fly", "refseq_name": "small ovary, isoform C", "refseq_ac": "NP_001284962", "gene_names_uniprotkb": "sov; CG14438; Dmel\\CG14438; Dmel_CG14438; EM25; Sov; fs(1)A1304; fs(1)M105; l(1)6Dc; l(1)EA42; l(1)EM25", "gene_names_refseq": "CG14438; Dmel\\CG14438; EM25; Sov; fs(1)A1304; fs(1)M105; l(1)6Dc; l(1)EA42; l(1)EM25; sov", "protein_names_uniprotkb": "Small ovary, isoform A; Small ovary, isoform B; Small ovary, isoform C", "protein_names_refseq": "CG14438-PC; female sterile (1) A1304; female sterile(1)M105; lethal (1) 6Dc; small ovary, isoform C; sov-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14438)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;35173350", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0031507 heterochromatin formation;GO:0141006 transposable element silencing by piRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W3W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3W7-1", "uniprot_id": "Q9W3W7_DROME", "mass": 58785.0, "length": 535, "protein_name": "Major facilitator superfamily (MFS) profile domain-containing protein", "gene_name": "Dmel\\CG14439", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001188550", "gene_names_uniprotkb": "Dmel\\CG14439; CG14439; Dmel_CG14439", "gene_names_refseq": "CG14439; Dmel\\CG14439", "protein_names_uniprotkb": "Major facilitator superfamily (MFS) profile domain-containing protein", "protein_names_refseq": "CG14439-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14439)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3W7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3X7-1", "uniprot_id": "Q9W3X7_DROME", "mass": 20203.0, "length": 175, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial", "gene_name": "ND-ASHI", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase (ubiquinone) ASHI subunit, isoform B", "refseq_ac": "NP_001027048", "gene_names_uniprotkb": "ND-ASHI; CG3192; Dmel\\CG3192; Dmel_CG3192; NDUFB8; NIAM; Ndufb8; Q9W3X7; dNDUFB8", "gene_names_refseq": "CG3192; Dmel\\CG3192; ND-ASHI; NDUFB8; NIAM; Ndufb8; Q9W3X7; dNDUFB8", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Complex I-ASHI; NADH-ubiquinone oxidoreductase ASHI subunit", "protein_names_refseq": "CG3192-PB; NADH dehydrogenase (ubiquinone) ASHI subunit, isoform B; NADH ubiquinone oxidoreductase ASHI; NADH-ubiquinone oxidoreductase ASHI subunit; NADH:ubiquinone oxidoreductase ASHI subunit; ND-ASHI-PB", "tax_id": 7227, "disease": "nuclear type mitochondrial complex I deficiency 32 (Disease Ontology:DOID:0112080); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (dme:Dmel_CG3192); (R-DME-1268020); (R-DME-611105); (R-DME-6799198)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;36622099;36952377", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W3X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3Z5-1", "uniprot_id": "Q9W3Z5_DROME", "mass": 35247.0, "length": 321, "protein_name": "Protein SREK1IP1", "gene_name": "Dmel\\CG3918", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572323", "gene_names_uniprotkb": "Dmel\\CG3918; CG3918; Dmel_CG3918", "gene_names_refseq": "CG3918; Dmel\\CG3918", "protein_names_uniprotkb": "Protein SREK1IP1", "protein_names_refseq": "CG3918-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3918)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Possible splicing regulator involved in the control of cellular survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3Z5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W402-1", "uniprot_id": "Q9W402_DROME", "mass": 17748.0, "length": 154, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "gene_name": "ND-B16.6", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase (ubiquinone) B16.6 subunit, isoform B", "refseq_ac": "NP_001284943", "gene_names_uniprotkb": "ND-B16.6; CG3446; Dmel\\CG3446; Dmel_CG3446; NB6M; NDUFA13; dNDUFA13", "gene_names_refseq": "CG3446; Dmel\\CG3446; NB6M; ND-B16.6; NDUFA13; dNDUFA13", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "protein_names_refseq": "CG3446-PB; NADH dehydrogenase (ubiquinone) B16.6 subunit, isoform B; NADH ubiquinone oxidoreductase B16.6; NADH-ubiquinone oxidoreductase B16.6 subunit; NADH:ubiquinone oxidoreductase B16.6 subunit; ND-B16.6-PB", "tax_id": 7227, "disease": "nuclear type mitochondrial complex I deficiency 28 (Disease Ontology:DOID:0112095); Parkinson's disease (Disease Ontology:DOID:14330); cerebral infarction (Disease Ontology:DOID:3526); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161)", "pathway": " (dme:Dmel_CG3446); (R-DME-611105); (R-DME-6799198); (R-DME-9837999)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;36622099;36952377", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes., [UniProtKB, UniProtKB]; Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W402-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W430-1", "uniprot_id": "Q9W430_DROME", "mass": 61904.0, "length": 553, "protein_name": "3.5.1.-; 3.5.1.12; Biotinidase", "gene_name": "Btnd", "organism": "Fruit fly", "refseq_name": "biotinidase", "refseq_ac": "NP_572298", "gene_names_uniprotkb": "Btnd; BTD; Btd; CG3599; CT12113; Dmel\\CG3599; Dmel_CG3599", "gene_names_refseq": "BTD; Btd; Btnd; CG3599; CT12113; Dmel\\CG3599", "protein_names_uniprotkb": "3.5.1.-; 3.5.1.12; Biotinidase", "protein_names_refseq": "Btnd-PA; CG3599-PA; biotinidase", "tax_id": 7227, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); biotinidase deficiency (Disease Ontology:DOID:856)", "pathway": " (dme:Dmel_CG3599)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0047708 biotinidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W430-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W438-1", "uniprot_id": "Q9W438_DROME", "mass": 52781.0, "length": 453, "protein_name": "Multiple inositol polyphosphate phosphatase 1", "gene_name": "Mipp2", "organism": "Fruit fly", "refseq_name": "multiple inositol polyphosphate phosphatase 2", "refseq_ac": "NP_511055", "gene_names_uniprotkb": "Mipp2; 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CG3009; Dmel_CG3009", "gene_names_refseq": "CG3009; Dmel\\CG3009", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4; Phosphatidylcholine 2-acylhydrolase", "protein_names_refseq": "CG3009-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3009); (R-DME-1482788); (R-DME-1482839); (R-DME-1482925)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W4I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W4J4-1", "uniprot_id": "Q9W4J4_DROME", "mass": 22877.0, "length": 215, "protein_name": "Casein kinase substrate phosphoprotein PP28 domain-containing protein", "gene_name": "Dmel\\CG11444", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001284863", "gene_names_uniprotkb": "Dmel\\CG11444; CG11444; Dmel_CG11444", "gene_names_refseq": "CG11444; Dmel\\CG11444", "protein_names_uniprotkb": "Casein kinase substrate phosphoprotein PP28 domain-containing protein", "protein_names_refseq": "CG11444-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (dme:Dmel_CG11444); (R-DME-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W4J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W4L5-1", "uniprot_id": "Q9W4L5_DROME", "mass": 63783.0, "length": 553, "protein_name": "BACK domain-containing protein", "gene_name": "Dmel\\CG12692", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": "NP_001284857", "gene_names_uniprotkb": "Dmel\\CG12692; 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CG15578; Dmel_CG15578", "gene_names_refseq": "CG15578; Dmel\\CG15578", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG15578-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15578)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W4L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W4N9-1", "uniprot_id": "GEM4A_DROME", "mass": 105015.0, "length": 911, "protein_name": "Gem-associated protein 4a", "gene_name": "Glos", "organism": "Fruit fly", "refseq_name": "gaulos, isoform B", "refseq_ac": "NP_001284848", "gene_names_uniprotkb": "Glos; CG2941; Gem4a; Gemin4", "gene_names_refseq": "CG2941; Dmel\\CG2941; GEMIN4; Gem4a; Gem4; Glos", "protein_names_uniprotkb": "Gem-associated protein 4a; Gemin4a; Protein Gaulos", "protein_names_refseq": "CG2941-PB; Gemin4a; Glos-PB; gaulos, isoform B", "tax_id": 7227, "disease": "neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities (Disease Ontology:DOID:0081263)", "pathway": " (dme:Dmel_CG2941)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;28949413;30563832;35861185", "class_list": "", "function": "Component of the survival motor neuron (SMN) complex that catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:28949413, PubMed:30563832). One of 3 almost identical paralogs (Glos/Gem4a, Gem4b and Gem4c), resulting from a genomic triplication, that have some redundant function (PubMed:30563832). 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Pepsinogen C-like", "gene_name": "Pgcl", "organism": "Fruit fly", "refseq_name": "pepsinogen C-like", "refseq_ac": "NP_525030", "gene_names_uniprotkb": "Pgcl; CG13374; Dmel\\CG13374; Dmel_CG13374; EG:EG0001.1; PCL; T2; pcl; scbeta", "gene_names_refseq": "CG13374; Dmel\\CG13374; EG:EG0001.1; PCL; Pgcl; T2; pcl; scbeta", "protein_names_uniprotkb": "3.4.23.-; Pepsinogen C-like", "protein_names_refseq": "CG13374-PA; Pgcl-PA; pepsinogen C-like; pepsinogen-like; scute beta", "tax_id": 7227, "disease": "atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (dme:Dmel_CG13374); (R-DME-2022377); (R-DME-2132295); (R-DME-5683826)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.22.15;3.4.23.-;3.4.22.41;3.4.-.-;3.4.22.-", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0001737 establishment of imaginal disc-derived wing hair orientation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W5G3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W5W6-1", "uniprot_id": "Q9W5W6_DROME", "mass": 32337.0, "length": 272, "protein_name": "TIP41-like protein", "gene_name": "Dmel\\CG9578", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_608377", "gene_names_uniprotkb": "Dmel\\CG9578; CG9578; Dmel_CG9578", "gene_names_refseq": "CG9578; Dmel\\CG9578", "protein_names_uniprotkb": "TIP41-like protein", "protein_names_refseq": "CG9578-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9578)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95TV2", "ec_number_list": "", "go_molecular_function": "GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0031929 TOR signaling;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W5W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XYW6-1", "uniprot_id": "Q9XYW6_DROME", "mass": 33864.0, "length": 289, "protein_name": "E3 ubiquitin-protein ligase CHIP", "gene_name": "STUB1", "organism": "Fruit fly", "refseq_name": "STIP1 homology and U-box containing protein 1", "refseq_ac": "NP_477441", "gene_names_uniprotkb": "STUB1; CG5203; CHIP; Chip; Dmel\\CG5203; Dmel_CG5203; Stub1; dCHIP", "gene_names_refseq": "CG5203; CHIP; Chip; Dmel\\CG5203; STUB1; Stub1; dCHIP", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CHIP; 2.3.2.27; RING-type E3 ubiquitin transferase CHIP", "protein_names_refseq": "CG5203-PA; CHIP ortholog; NM 058093.3; STIP1 homology and U-box containing protein 1; STUB1-PA", "tax_id": 7227, "disease": "autosomal recessive spinocerebellar ataxia 16 (Disease Ontology:DOID:0080029); cerebellar ataxia type 48 (Disease Ontology:DOID:0111746); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (dme:Dmel_CG5203); (R-DME-2173788); (R-DME-8863795); (R-DME-8939902); (R-DME-8948751); (R-DME-983168)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;2.3.2.25;2.3.2.23;2.3.2.31;2.7.10.1;2.3.2.26;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0030911 TPR domain binding;GO:0051087 protein-folding chaperone binding;GO:0061630 ubiquitin protein ligase activity;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0031943 regulation of glucocorticoid metabolic process;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9XYW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XZ32-1", "uniprot_id": "Q9XZ32_DROME", "mass": 156646.0, "length": 1398, "protein_name": "UBC core domain-containing protein", "gene_name": "BcDNA:LD22087; Dmel\\CG10254", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": "NP_651170", "gene_names_uniprotkb": "BcDNA:LD22087; Dmel\\CG10254; BcDNA:LD22087; CG10254; Dmel\\CG10254; Dmel_CG10254", "gene_names_refseq": "BcDNA:LD22087; CG10254; Dmel\\CG10254", "protein_names_uniprotkb": "UBC core domain-containing protein", "protein_names_refseq": "CG10254-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10254); (R-DME-983168)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9XZ32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XZS4-1", "uniprot_id": "Q9XZS4_DROME", "mass": 17741.0, "length": 158, "protein_name": "RING-type domain-containing protein", "gene_name": "Dmel\\CG4325", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001259169", "gene_names_uniprotkb": "Dmel\\CG4325; CG4325; Dmel_CG4325; EG:22E5.12", "gene_names_refseq": "CG4325; Dmel\\CG4325; EG:22E5.12", "protein_names_uniprotkb": "RING-type domain-containing protein", "protein_names_refseq": "CG4325-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4325)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination;GO:0006963 positive regulation of antibacterial peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9XZS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XZS9-1", "uniprot_id": "Q9XZS9_DROME", "mass": 96596.0, "length": 861, "protein_name": "DNA 5'-3' helicase", "gene_name": "cg11403", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_569898", "gene_names_uniprotkb": "cg11403; CG11403; Chl1; Dmel\\CG11403; Dmel_CG11403; EG:33C11.2", "gene_names_refseq": "CG11403; Chl1; Dmel\\CG11403; EG:33C11.2; cg11403", "protein_names_uniprotkb": "DNA 5'-3' helicase; 5.6.2.3", "protein_names_refseq": "CG11403-PA; DNA helicase; uncharacterized protein", "tax_id": 7227, "disease": "Warsaw breakage syndrome (Disease Ontology:DOID:0060535)", "pathway": " (dme:Dmel_CG11403)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004386 helicase activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process;GO:0034085 establishment of sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9XZS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XZU0-1", "uniprot_id": "Q9XZU0_DROME", "mass": 39335.0, "length": 357, "protein_name": "PvuII-PstI homology 13", "gene_name": "Pph13", "organism": "Fruit fly", "refseq_name": "PvuII-PstI homology 13", "refseq_ac": "NP_477330", "gene_names_uniprotkb": "Pph13; 60Mun1; CG2819; Dmel\\CG2819; Dmel_CG2819; Mu; PPH13; hazy; pph13", "gene_names_refseq": "60Mun1; CG2819; Dmel\\CG2819; Mu; PPH13; Pph13; hazy; pph13", "protein_names_uniprotkb": "PvuII-PstI homology 13", "protein_names_refseq": "CG2819-PA; Pph13-PA; PvuII-PstI homology 13; hazy; munster", "tax_id": 7227, "disease": "parietal foramina (Disease Ontology:DOID:0060285); frontonasal dysplasia 1 (Disease Ontology:DOID:0081045); frontonasal dysplasia 2 (Disease Ontology:DOID:0081046); frontonasal dysplasia 3 (Disease Ontology:DOID:0081047); lung cancer (Disease Ontology:DOID:1324); craniosynostosis (Disease Ontology:DOID:2340); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG2819)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0048666 neuron development;GO:0042461 photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9XZU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Y112-1", "uniprot_id": "Q9Y112_DROME", "mass": 36312.0, "length": 316, "protein_name": "NADP-dependent oxidoreductase domain-containing protein", "gene_name": "Ar3", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_647840", "gene_names_uniprotkb": "Ar3; AKR2E3; Akr2E3; BcDNA:GH10614; CG10863; Dmel\\CG10863; Dmel_CG10863", "gene_names_refseq": "BcDNA:GH10614; CG10863; Dmel\\CG10863; dm1/AKR2E3", "protein_names_uniprotkb": "NADP-dependent oxidoreductase domain-containing protein", "protein_names_refseq": "CG10863-PA; uncharacterized protein", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); ductal carcinoma in situ (Disease Ontology:DOID:0060074); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); congenital bile acid synthesis defect 2 (Disease Ontology:DOID:0111069); 46,XY sex reversal 8 (Disease Ontology:DOID:0111773); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); leukemia (Disease Ontology:DOID:1240); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG10863)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Y112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9Y125-1", "uniprot_id": "Q9Y125_DROME", "mass": 105963.0, "length": 953, "protein_name": "Saposin-related, isoform A", "gene_name": "Sap-r", "organism": "Fruit fly", "refseq_name": "Saposin-related, isoform A", "refseq_ac": "NP_524597", "gene_names_uniprotkb": "Sap-r; Apa; BcDNA:GH08312; CG12070; DAPA; Dmel\\CG12070; Dmel_CG12070; Ov9; P110; Sap-R; Sapr; anon-EST:ParkEST270; sap-r", "gene_names_refseq": "Apa; BcDNA:GH08312; CG12070; DAPA; Dmel\\CG12070; Ov9; P110; Sap-R; Sap-r; Sapr; anon-EST:ParkEST270; sap-r", "protein_names_uniprotkb": "Saposin-related, isoform A", "protein_names_refseq": "110kD protein; CG12070-PA; Sap-r-PA; Saposin-related, isoform A; Saposin-r; drosophila aggregation promoting activity; saposin-related", "tax_id": 7227, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); late onset Parkinson's disease (Disease Ontology:DOID:0060892); atypical Gaucher's disease due to saposin c deficiency (Disease Ontology:DOID:0110961); combined saposin deficiency (Disease Ontology:DOID:0111330); metachromatic leukodystrophy (Disease Ontology:DOID:10581); Krabbe disease (Disease Ontology:DOID:10587); respiratory failure (Disease Ontology:DOID:11162); adult respiratory distress syndrome (Disease Ontology:DOID:11394); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); lung cancer (Disease Ontology:DOID:1324); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (dme:Dmel_CG12070); (R-DME-114608); (R-DME-5683826); (R-DME-6798695); (R-DME-9840310)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome;GO:0005770 late endosome;GO:0005776 autophagosome", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0006665 sphingolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Y125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "R9PY35-1", "uniprot_id": "R9PY35_DROME", "mass": 39688.0, "length": 345, "protein_name": "Uncharacterized protein", "gene_name": "CG34406", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_608754", "gene_names_uniprotkb": "CG34406; CG18555; CG34406-2; CG44002; Dmel\\CG44002; Dmel_CG44002", "gene_names_refseq": "CG18555; CG34406-2; CG34406; CG44002; Dmel\\CG44002", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG44002-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG44002)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "R9PY35-1", "record_type": "protein" }, { "uniprot_canonical_ac": "R9PY62-1", "uniprot_id": "R9PY62_DROME", "mass": 136562.0, "length": 1249, "protein_name": "GRAM domain containing 1B, isoform E", "gene_name": "GramD1B", "organism": "Fruit fly", "refseq_name": "GRAM domain containing 1B, isoform E", "refseq_ac": "NP_995623", "gene_names_uniprotkb": "GramD1B; BcDNA:RE58243; CG15411; CG3304; CG34394; Dmel\\CG34394; Dmel_CG34394", "gene_names_refseq": "BcDNA:RE58243; CG15411; CG3304; CG34394; Dmel\\CG34394; GramD1B", "protein_names_uniprotkb": "GRAM domain containing 1B, isoform E", "protein_names_refseq": "CG34394-PE; GRAM domain containing 1B, isoform E; GramD1B-PE", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34394)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0032934 sterol binding;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site;GO:0044232 organelle membrane contact site;GO:0016020 membrane", "go_biological_process": "GO:0032366 intracellular sterol transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "R9PY62-1", "record_type": "protein" }, { "uniprot_canonical_ac": "V9HVU8-1", "uniprot_id": "V9HVU8_DROME", "mass": 22849.0, "length": 199, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG18545", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_649998", "gene_names_uniprotkb": "Dmel\\CG18545; CG18545-PA; CG18545; Dmel_CG18545", "gene_names_refseq": "CG18545-PA; CG18545; Dmel\\CG18545", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG18545-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18545)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "V9HVU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X2JD93-1", "uniprot_id": "X2JD93_DROME", "mass": 10544.0, "length": 90, "protein_name": "Cytochrome c oxidase subunit 6C-like, isoform C", "gene_name": "COX6CL", "organism": "Fruit fly", "refseq_name": "cytochrome c oxidase subunit 6C-like, isoform C", "refseq_ac": "NP_001285640", "gene_names_uniprotkb": "COX6CL; BcDNA:AT20031; CG31644; Dmel\\CG31644; Dmel_CG31644", "gene_names_refseq": "BcDNA:AT20031; CG31644; COX6CL; Dmel\\CG31644", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6C-like, isoform C", "protein_names_refseq": "CG31644-PC; COX6CL-PC; cytochrome c oxidase subunit 6C-like, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31644)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2JD93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X2J7Z6-1", "uniprot_id": "X2J7Z6_DROME", "mass": 7293.0, "length": 65, "protein_name": "Kazal-like domain-containing protein", "gene_name": "Dmel\\CG45012", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_001285850", "gene_names_uniprotkb": "Dmel\\CG45012; CG45012; Dmel_CG45012", "gene_names_refseq": "CG45012; Dmel\\CG45012", "protein_names_uniprotkb": "Kazal-like domain-containing protein", "protein_names_refseq": "CG45012-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG45012)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2J7Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "X2JBU2-1", "uniprot_id": "X2JBU2_DROME", "mass": 23339.0, "length": 213, "protein_name": "Probable RNA-binding protein 18", "gene_name": "BcDNA:AT01764; Dmel\\CG14414", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": "NP_001285240", "gene_names_uniprotkb": "BcDNA:AT01764; Dmel\\CG14414; BcDNA:AT01764; CG14414; Dmel\\CG14414; Dmel_CG14414; cg14414", "gene_names_refseq": "BcDNA:AT01764; CG14414; Dmel\\CG14414; cg14414", "protein_names_uniprotkb": "Probable RNA-binding protein 18; RNA-binding motif protein 18", "protein_names_refseq": "CG14414-PE; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14414)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2JBU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z9X0-1", "uniprot_id": "APKC_DROME", "mass": 69556.0, "length": 606, "protein_name": "Atypical protein kinase C", "gene_name": "aPKC", "organism": "Fruit fly", "refseq_name": "atypical protein kinase C, isoform C", "refseq_ac": "NP_001036541", "gene_names_uniprotkb": "aPKC; CG10261; CG30475; CG42783; DaPKC; Dmel\\CG42783; Dmel_CG42783; PKCl; PKCzeta; PKC; a-PKC; aPKC zeta; aPKC-zeta; aPKCzeta; aPkc; alphaPKCzeta; alphaPKC; apkc; daPKC; dapkc; i; l(2)k06403; pkc-3; psu", "gene_names_refseq": "CG10261; CG30475; CG42783; DaPKC; Dmel\\CG42783; PKCl; PKCzeta; PKC; a-PKC; aPKC zeta; aPKC-zeta; aPKCzeta; aPKC; aPkc; alphaPKCzeta; alphaPKC; apkc; daPKC; dapkc; i; l(2)k06403; pkc-3; psu", "protein_names_uniprotkb": "Atypical protein kinase C; 2.7.11.13", "protein_names_refseq": "CG42783-PC; aPKC-PC; atypical PKC; atypical protein kinase C, isoform C; atypical protein kinase C; atypical protein kinase; atypical-Protein kinase C; pschur", "tax_id": 7227, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); ovarian carcinoma (Disease Ontology:DOID:4001); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG42783); (R-DME-2173791); (R-DME-5218921); (R-DME-9634635); (R-DME-9755511)", "pathway_count": 5, "publication_count": 27, "publication_id_list": "10731132;10995441;11734648;11914720;12446795;12537568;12537569;12537572;12537573;12537574;14657233;15302858;15907474;16110336;17488624;17569856;17569867;18094021;18614576;19472188;20434988;22223679;24515345;24830287;25589440;26109356;26109357", "class_list": "", "function": "Serine/threonine protein kinase which is required for apico-basal cell polarity in the germ line as well as in epithelial and neural precursor cells, for epithelial planar cell polarity and for cell proliferation. During oocyte development, required for the posterior translocation of oocyte specification factors and for the posterior establishment of the microtubule organizing center within the presumptive oocyte. Phosphorylates l(2)gl which restricts l(2)gl activity to the oocyte posterior and regulates posterior enrichment of par-1, leading to establishment of correct oocyte polarity. Essential for apical localization of l(2)gl and par-6 in neuroblasts and for exclusion of mira from the apical cortex. Phosphorylates baz which is required for targeting of baz to the postsynaptic region where it is involved in actin organization, and for apical exclusion of baz which is necessary for establishment of the apical/lateral border in epithelial cells. Phosphorylates yrt which prevents its premature apical localization and is necessary for correct epithelial cell polarization. Required for the establishment of mitotic spindle orientation during symmetric division of epithelial cells and for apical exclusion of raps/Pins. Involved in symmetric adherens junction positioning during embryogenesis. Required for polarization of the spermatid cyst which is necessary for sperm differentiation. Required for stimulation of the Toll signaling pathway which activates Dif and dl and plays a role in innate immunity. Plays a role in memory enhancement., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E971;Q0E972;Q0E973;Q0E974;Q8MT38;Q9GSZ3", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.30;2.7.11.22;2.7.11.21;3.6.5.2;5.6.1.8;2.7.11.11;2.7.11.23;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;2.3.2.26;2.7.11.39;2.7.1.91", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0017022 myosin binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0045179 apical cortex;GO:0005938 cell cortex;GO:0016324 apical plasma membrane;GO:0043296 apical junction complex;GO:0035003 subapical complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0051601 exocyst localization;GO:0016332 establishment or maintenance of polarity of embryonic epithelium;GO:0007283 spermatogenesis;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "A1Z9X0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z9R4-1", "uniprot_id": "ZN423_DROME", "mass": 134177.0, "length": 1228, "protein_name": "Zinc finger protein 423 homolog", "gene_name": "L", "organism": "Fruit fly", "refseq_name": "lobe, isoform B", "refseq_ac": "NP_001097315", "gene_names_uniprotkb": "L; CG17388; CG17389; CG17390; CG42702; Dm_2R:42259; Dmel\\CG42702; Dmel_CG42702; Oaz; dmOAZ; fee; l(2)03563; oaz", "gene_names_refseq": "CG17388; CG17389; CG17390; CG42702; Dm_2R:42259; Dmel\\CG42702; L; Oaz; dmOAZ; fee; l(2)03563; oaz", "protein_names_uniprotkb": "Zinc finger protein 423 homolog; O/E-associated zinc finger protein; Protein Lobe", "protein_names_refseq": "CG42702-PB; L-PB; O/E-associated zinc finger protein; freaky eye; lethal (2) 03563; lobe, isoform B; lobe", "tax_id": 7227, "disease": "nephronophthisis 14 (Disease Ontology:DOID:0111122); Dandy-Walker syndrome (Disease Ontology:DOID:2785); cerebellar disease (Disease Ontology:DOID:2786); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG42702)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17323106;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Probable transcription factor that can both act as an activator or a repressor depending on the context (By similarity). Involved in posterior spiracle development. Acts downstream of ems and cut in posterior spiracle development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T496", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0035277 spiracle morphogenesis, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A1Z9R4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O96553-1", "uniprot_id": "C1TC_DROME", "mass": 103504.0, "length": 968, "protein_name": "C-1-tetrahydrofolate synthase, cytoplasmic", "gene_name": "pug", "organism": "Fruit fly", "refseq_name": "pugilist, isoform D", "refseq_ac": "NP_001014614", "gene_names_uniprotkb": "pug; CG4067; Dmel\\CG4067; Dmel_CG4067; MTHFD; Pug; bs14h02.y1; pugD", "gene_names_refseq": "CG4067; Dmel\\CG4067; MTHFD; Pug; bs14h02.y1; pugD; pug", "protein_names_uniprotkb": "C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase", "protein_names_refseq": "CG4067-PD; pug-PD; pugilist, isoform D; pugilist", "tax_id": 7227, "disease": "spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); developmental cardiac valvular defect (Disease Ontology:DOID:0080633); Down syndrome (Disease Ontology:DOID:14250); tetralogy of Fallot (Disease Ontology:DOID:6419); cleft palate (Disease Ontology:DOID:674); abdominal aortic aneurysm (Disease Ontology:DOID:7693); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (dme:Dmel_CG4067); (R-DME-196757)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9832531", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V2N7;A4V2N9;Q5BIE6;Q8T0P2", "ec_number_list": "6.3.4.3;1.5.1.5;3.5.4.9;1.5.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0008652 amino acid biosynthetic process;GO:0035999 tetrahydrofolate interconversion;GO:0046653 tetrahydrofolate metabolic process;GO:0000105 L-histidine biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O96553-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O01352-1", "uniprot_id": "DJ_DROME", "mass": 29127.0, "length": 248, "protein_name": "Sperm-specific protein Don juan", "gene_name": "dj", "organism": "Fruit fly", "refseq_name": "don juan, isoform B", "refseq_ac": "NP_477220", "gene_names_uniprotkb": "dj; CG1980; DJ; Dj; Dmel\\CG1980; Dmel_CG1980; bs02h03.y1", "gene_names_refseq": "CG1980; DJ; Dj; Dmel\\CG1980; bs02h03.y1; dj", "protein_names_uniprotkb": "Sperm-specific protein Don juan", "protein_names_refseq": "CG1980-PB; Don juan; dj-PB; don juan, isoform B; don-juan", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1980)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9232593;9788872", "class_list": "", "function": "May be involved in the final steps of mitochondrial differentiation within the flagellum., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8INS3;Q9VI50", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0016007 mitochondrial derivative", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O01352-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z6E0-1", "uniprot_id": "GUS_DROME", "mass": 31713.0, "length": 279, "protein_name": "Protein gustavus", "gene_name": "gus", "organism": "Fruit fly", "refseq_name": "gustavus, isoform G", "refseq_ac": "NP_001246140", "gene_names_uniprotkb": "gus; A11; CG2944; CG2946; Dmel\\CG2944; Dmel_CG2944; GUS; Gus; dmSSB4; i25", "gene_names_refseq": "A11; CG2944; CG2946; Dmel\\CG2944; GUS; Gus; dmSSB4; gus; i25", "protein_names_uniprotkb": "Protein gustavus", "protein_names_refseq": "CG2944-PG; gus-PG; gustavus, isoform G; gustavus", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2944); (R-DME-8951664); (R-DME-983168)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10731132;12479811;12537568;12537569;12537572;12537573;12537574;16110336;16498413;17189197;17569856;17569867;20123973;25589440;26109356;26109357", "class_list": "", "function": "Involved in the localization of vas to the posterior pole of the oocyte. Required maternally in the germ line for efficient primordial germ cell formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1Z6D7;A1Z6D9;A1Z6E2;F2FB59;Q7JUY1", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0048471 perinuclear region of cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0008104 intracellular protein localization;GO:0045732 positive regulation of protein catabolic process;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "A1Z6E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A0B4K859-1", "uniprot_id": "NU188_DROME", "mass": 213609.0, "length": 1866, "protein_name": "Nucleoporin Nup188", "gene_name": "Nup188", "organism": "Fruit fly", "refseq_name": "nucleoporin 188kDa, isoform C", "refseq_ac": "NP_001246283", "gene_names_uniprotkb": "Nup188; CG8771", "gene_names_refseq": "CG8771; Dmel\\CG8771; Nup188; nup188", "protein_names_uniprotkb": "Nucleoporin Nup188; Nucleoporin 188kDa", "protein_names_refseq": "CG8771-PC; Nup188-PC; nucleoporin 188kDa, isoform C", "tax_id": 7227, "disease": "Sandestig-Stefanova syndrome (Disease Ontology:DOID:0081272); respiratory failure (Disease Ontology:DOID:11162)", "pathway": " (dme:Dmel_CG8771); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 3, "publication_id_list": "10731132;12537572;32275884", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Required for proper protein transport into the nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1Z945", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0044611 nuclear pore inner ring", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0B4K859-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1ZAU8-1", "uniprot_id": "PTRO_DROME", "mass": 183622.0, "length": 1630, "protein_name": "Patronin", "gene_name": "Patronin", "organism": "Fruit fly", "refseq_name": "patronin, isoform A", "refseq_ac": "NP_788398", "gene_names_uniprotkb": "Patronin; BcDNA:LD17191; CG18459; CG18460; CG18462; CG30102; CG33130; CG6516; Dmel\\CG33130; Dmel_CG33130; Patr; Ssp4; l(2)k07433; patronin; ptrn; ssp4", "gene_names_refseq": "BcDNA:LD17191; CG18459; CG18460; CG18462; CG30102; CG33130; CG6516; Dmel\\CG33130; Patronin; Patr; Ssp4; l(2)k07433; patronin; ptrn; ssp4", "protein_names_uniprotkb": "Patronin; Short spindle protein 4", "protein_names_refseq": "CG33130-PA; Patronin-PA; lethal (2) k07433; patronin, isoform A; patronin; short spindle 4", "tax_id": 7227, "disease": "complex cortical dysplasia with other brain malformations 12 (Disease Ontology:DOID:0061141)", "pathway": " (dme:Dmel_CG33130)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17412918;17569856;17569867;18327897;20946984;24100293;25589440;26109356;26109357;26246606;26659188;32066907", "class_list": "", "function": "Key microtubule-organizing protein that specifically binds the minus-end of microtubules and regulates their dynamics and organization (PubMed:17412918, PubMed:20946984, PubMed:24100293, PubMed:26246606, PubMed:32066907). Involved in mitotic spindle assembly (PubMed:17412918, PubMed:26246606). Regulates microtubule (MT) severing (PubMed:17412918). Antagonizes the activity of the kinesin-13 depolymerase Klp10A thereby switching off the depolymerization of the MTs at their pole-associated minus ends, which turns off poleward flux and induces anaphase B spindle elongation (PubMed:20946984, PubMed:24100293). Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188). In fat body cells, part of perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) which function to accommodate the organization of microtubule (MT) networks to control nuclear positioning and dynein motor-based retrograde endosomal trafficking (PubMed:32066907). Within the ncMTOC, Msp300 and shot anchors the ncMTOC at the nuclear surface and recruits the MT minus-end regulators Patronin and Nin for assembly, anchoring and/or stabilization of circumferential and radial MTs at the ncMTOCs (PubMed:32066907). This protein, and perhaps Nin, recruits msps to the ncMTOC for the gamma-tubulin-independent elongation of radial MTs (PubMed:32066907)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1ZAU9;A1ZAV0;Q86NU5;Q8MSU7", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0030496 midbody", "go_biological_process": "GO:0031175 neuron projection development;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization;GO:0035331 negative regulation of hippo signaling;GO:0051298 centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "A1ZAU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z897-1", "uniprot_id": "SDF2B_DROME", "mass": 18380.0, "length": 156, "protein_name": "Succinate dehydrogenase assembly factor 2-B, mitochondrial", "gene_name": "Dmel\\CG12895", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001260868", "gene_names_uniprotkb": "Dmel\\CG12895; BcDNA:RE29446; CG12895; Dmel_CG12895", "gene_names_refseq": "BcDNA:RE29446; CG12895; Dmel\\CG12895", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 2-B, mitochondrial; SDH assembly factor 2-B; SDHAF2-B", "protein_names_refseq": "CG12895-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "pheochromocytoma/paraganglioma syndrome 2 (Disease Ontology:DOID:0061217)", "pathway": " (dme:Dmel_CG12895)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYX8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0018293 protein-FAD linkage;GO:0034553 mitochondrial respiratory chain complex II assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A1Z897-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z8P9-1", "uniprot_id": "TPR_DROME", "mass": 262353.0, "length": 2346, "protein_name": "Nucleoprotein TPR", "gene_name": "Mgtor", "organism": "Fruit fly", "refseq_name": "megator, isoform B", "refseq_ac": "NP_001260903", "gene_names_uniprotkb": "Mgtor; Bx34; CG8274; Dmel\\CG8274; Dmel_CG8274; MTOR; Mtor; TPR; Tpr; l(2)k03905; mtor", "gene_names_refseq": "Bx34; CG8274; Dmel\\CG8274; MTOR; Mgtor; Mtor; TPR; Tpr; l(2)k03905; mtor", "protein_names_uniprotkb": "Nucleoprotein TPR; Nuclear envelope antigen Bx34; Protein megator", "protein_names_refseq": "CG8274-PB; Mgtor-PB; lethal (2) k03905; megator, isoform B", "tax_id": 7227, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (dme:Dmel_CG8274); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 25, "publication_id_list": "10731132;12027452;12537568;12537572;12537573;12537574;15356261;15962301;16110336;16543150;17569856;17569867;18562695;19273613;19890914;20174442;22855526;25589440;26109356;26109357;26714316;28366641;31913420;34133927;9152019", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:9152019). Functions as a scaffolding element in the nuclear phase of the NPC (PubMed:12027452, PubMed:15356261). Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment (PubMed:12027452, PubMed:20174442). Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome (PubMed:20174442). Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy (PubMed:20174442). Preferentially binds to NARs of the male X chromosome (PubMed:20174442). In males, together with Nup153, required for the localization of the male-specific lethal (MSL) histone acetyltransferase complex to the X chromosome and therefore for the transcription of dosage compensation genes (PubMed:16543150). In males, restrains dosage-compensated expression at the level of nascent transcription probably by interacting with the MSL complex and by modulating RNA Polymerase II phosphorylation status and activity (PubMed:34133927). During mitosis forms a gel-like spindle matrix complex together with Skeletor (Skel), Chro, east, and Asator embedding the microtubule spindle apparatus (PubMed:15356261, PubMed:15962301, PubMed:19273613, PubMed:22855526). During interphase localizes Mad1 to the nuclear pore complex and thereby might act as a scaffold to assemble the Mad1-C-Mad2 complex, a heterotetramer that catalyzes the structural conversion of open-Mad2 (O-Mad2) into closed-Mad2 (C-Mad2) which is essential for spindle-assembly checkpoint (SAC) (PubMed:31913420). During the metaphase-anaphase transition and before chromosome congression, is phosphorylated by Msp-1; this modification releases Mad1 from the nuclear pore complex and thereby promotes assembly of SAC ensuring a timely and effective recruitment of spindle checkpoint proteins like Mad1, Mad2 and Mps1 to unattached kinetochores (KT) (PubMed:22855526, PubMed:26714316, PubMed:31913420). In testes, has a role in stem cell asymmetric division and maintenance via regulation of mitotic spindle assembly checkpoint (SAC) complex (PubMed:26714316)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O01385", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0031490 chromatin DNA binding;GO:0017056 structural constituent of nuclear pore;GO:0035035 histone acetyltransferase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0090235 regulation of metaphase plate congression;GO:0048133 male germ-line stem cell asymmetric division;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "A1Z8P9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F3YDF1-1", "uniprot_id": "YMEL1_DROME", "mass": 81081.0, "length": 740, "protein_name": "ATP-dependent zinc metalloprotease YME1L", "gene_name": "YME1L", "organism": "Fruit fly", "refseq_name": "YME1 like ATPase, isoform C", "refseq_ac": "NP_001246473", "gene_names_uniprotkb": "YME1L; CG3499; DmCG3499; Dmel\\CG3499; Dmel_CG3499; dYME1L1; dYME1L", "gene_names_refseq": "CG3499; DmCG3499; Dmel\\CG3499; YME1L; dYME1L1; dYME1L", "protein_names_uniprotkb": "ATP-dependent zinc metalloprotease YME1L; 3.4.24.-; YME1-like ATPase", "protein_names_refseq": "CG3499-PC; YME1 like ATPase, isoform C; YME1L-PC", "tax_id": 7227, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); optic atrophy 11 (Disease Ontology:DOID:0111436); dilated cardiomyopathy (Disease Ontology:DOID:12930); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG3499); (R-DME-8949664); (R-DME-9837999)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26160069;31125351", "class_list": "", "function": "ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26160069). Plays an important role in regulating mitochondrial morphology and function by cleaving Opa1, giving rise to a form of Opa1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:31125351). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:26160069, PubMed:31125351). Required to control the accumulation of nonassembled respiratory chain subunits such as ND-30 (PubMed:26160069)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MMD4;Q9W1Y0", "ec_number_list": "3.4.24.-;7.1.1.9;3.4.24.64", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005745 m-AAA complex;GO:0031942 i-AAA complex;GO:0016020 membrane", "go_biological_process": "GO:0034982 mitochondrial protein processing;GO:0035694 mitochondrial protein catabolic process;GO:0141164 mitochondrial protein quality control;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "F3YDF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B5A5T4-1", "uniprot_id": "QVR_DROME", "mass": 18124.0, "length": 158, "protein_name": "UPAR/Ly6 domain-containing protein qvr", "gene_name": "qvr", "organism": "Fruit fly", "refseq_name": "quiver, isoform B", "refseq_ac": "NP_001137646", "gene_names_uniprotkb": "qvr; BcDNA:GH06755; CG30032; CG33472; Dmel\\CG33472; Dmel_CG33472; Qvr; anon-WO02059370.1; mdcds_22455; sleepless; sss", "gene_names_refseq": "BcDNA:GH06755; CG30032; CG33472; Dmel\\CG33472; Qvr; anon-WO02059370.1; mdcds_22455; qvr/sleepless; qvr; sss", "protein_names_uniprotkb": "UPAR/Ly6 domain-containing protein qvr; Protein quiver; Protein sleepless", "protein_names_refseq": "CG33472-PB; quiver, isoform B; qvr-PB; sleepless", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33472)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10731132;10934243;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18635795;20010822;20429677;21813698;24516136;24613312;25589440;26109356;26109357;26828958;29117754;8776866", "class_list": "", "function": "Bifunctional regulator of neuronal activity in the mushroom body, and possibly other regions of the brain, that acts as a signaling molecule required for homeostatic regulation of sleep under normal conditions and after sleep deprivation (PubMed:18635795, PubMed:20010822, PubMed:24613312). Reduces neuronal excitability by enhancing Sh/shaker K(+) channel activity; possibly by stabilizing Sh/shaker to increase protein levels, accelerating its activation kinetics, slowing C-type inactivation and enhancing recovery from inactivation (PubMed:10934243, PubMed:18635795, PubMed:20010822, PubMed:20429677, PubMed:21813698, PubMed:24613312). Specifically affects the A-type K(+) current (PubMed:10934243). Antagonizes nicotinic acetylcholine receptors (nAChRs) to reduce synaptic transmission, possibly by preventing their localization to the cell surface (PubMed:24613312, PubMed:26828958). Required for regulation of neuromuscular excitability and plasticity at neuromuscular junctions (PubMed:29117754)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1Z8M0;B7YZF3;Q8SXP9", "ec_number_list": "", "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0030550 acetylcholine receptor inhibitor activity;GO:0099104 potassium channel activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep;GO:0030431 sleep;GO:0048511 rhythmic process;GO:0045837 negative regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "B5A5T4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z9A2-1", "uniprot_id": "U587_DROME", "mass": 18606.0, "length": 163, "protein_name": "UPF0587 protein CG4646", "gene_name": "Dmel\\CG4646", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001286382", "gene_names_uniprotkb": "Dmel\\CG4646; BcDNA:SD14289; CG4646; Dmel_CG4646", "gene_names_refseq": "BcDNA:SD14289; CG4646; Dmel\\CG4646", "protein_names_uniprotkb": "UPF0587 protein CG4646", "protein_names_refseq": "CG4646-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4646)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRY1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "A1Z9A2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HK92-1", "uniprot_id": "Y5076_DROME", "mass": 68642.0, "length": 619, "protein_name": "Uncharacterized protein CG45076", "gene_name": "Dmel\\CG45076", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": "NP_001287274", "gene_names_uniprotkb": "Dmel\\CG45076; CG45076; CG6544; Dmel_CG45076", "gene_names_refseq": "CG45076; CG6544; Dmel\\CG45076", "protein_names_uniprotkb": "Uncharacterized protein CG45076", "protein_names_refseq": "CG45076-PE; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG45076)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;40245499", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EQU5;Q95S18;Q9VGX1;Q9VGX2;Q9VGX3;Q9Y0F9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "C0HK92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1YK02-1", "uniprot_id": "NUP75_DROME", "mass": 76872.0, "length": 668, "protein_name": "Nuclear pore complex protein Nup75", "gene_name": "Nup75", "organism": "Fruit fly", "refseq_name": "nucleoporin 75kD", "refseq_ac": "NP_611300", "gene_names_uniprotkb": "Nup75; CG5733", "gene_names_refseq": "CG5733; Dmel\\CG5733; Nup 75; Nup75; nup75", "protein_names_uniprotkb": "Nuclear pore complex protein Nup75; 75 KDa Nucleoporin; Nucleoporin Nup75; Nucleoporin Nup85", "protein_names_refseq": "CG5733-PA; Nup75-PA; nucleoporin 75kD; nucleoporin 75", "tax_id": 7227, "disease": "nephrotic syndrome type 17 (Disease Ontology:DOID:0080392)", "pathway": " (dme:Dmel_CG5733); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;20547758", "class_list": "", "function": "Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758). Facilitates the interaction between Nup93 and sec13 with msk (PubMed:20547758)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZH5", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0045893 positive regulation of DNA-templated transcription;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1YK02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z6H7-1", "uniprot_id": "PO210_DROME", "mass": 209792.0, "length": 1876, "protein_name": "Nuclear pore membrane glycoprotein 210", "gene_name": "Gp210", "organism": "Fruit fly", "refseq_name": "glycoprotein 210 kDa, isoform B", "refseq_ac": "NP_001260714", "gene_names_uniprotkb": "Gp210; CG7897; Gp188; lyadi", "gene_names_refseq": "CG14467; CG7897; Dm gp210; Dmel\\CG7897; GP210; Gp188; Gp210; dmNUP210; gp188; gp210[[D]]; gp210; lyadi", "protein_names_uniprotkb": "Nuclear pore membrane glycoprotein 210; Glycoprotein 210 kDa; Nuclear pore membrane glycoprotein gp188; Nuclear pore protein gp210; Nucleoporin Nup210; Nup210", "protein_names_refseq": "CG7897-PB; Gp210 ortholog; Gp210-PB; glycoprotein 210 kDa, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7897); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 7, "publication_id_list": "10731132;12537572;17682050;2517292;33925313;3919018;7641726", "class_list": "", "function": "Component of the nuclear pore complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6NP18;Q9GPI0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A1Z6H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z6M6-1", "uniprot_id": "CNS1_DROME", "mass": 46906.0, "length": 396, "protein_name": "Hsp70/Hsp90 co-chaperone CNS1 homolog", "gene_name": "Dpit47", "organism": "Fruit fly", "refseq_name": "DNA polymerase interacting tpr containing protein of 47kD, isoform B", "refseq_ac": "NP_001260729", "gene_names_uniprotkb": "Dpit47; CG3189", "gene_names_refseq": "CG3189; Dmel\\CG3189; Dpit47; cn20", "protein_names_uniprotkb": "Hsp70/Hsp90 co-chaperone CNS1 homolog; DNA polymerase interacting TPR-containing, protein of 47 kDa; DNA polymerase interacting tetratricopeptide repeat-containing, protein of 47 kDa; TPR repeat protein 4 homolog; Tetratricopeptide repeat protein 4 homolog", "protein_names_refseq": "CG3189-PB; DNA polymerase interacting tpr containing protein of 47kD, isoform B; Dpit47-PB; cn20", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3189)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11493638;12537569;12537572", "class_list": "", "function": "Co-chaperone that recruits molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1) to nascent polypeptides, facilitating their proper folding into functional proteins (PubMed:11493638). Client proteins include eukaryotic elongation factor eEF2, a key player in cellular translation. Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NMU5", "ec_number_list": "", "go_molecular_function": "GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1Z6M6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z6W3-1", "uniprot_id": "PRIC1_DROME", "mass": 140722.0, "length": 1299, "protein_name": "Protein prickle", "gene_name": "pk", "organism": "Fruit fly", "refseq_name": "prickle, isoform A", "refseq_ac": "NP_724534", "gene_names_uniprotkb": "pk; CG11084", "gene_names_refseq": "CG11084; CG12830; Dmel\\CG11084; PK; Pk-Sple; Pk; Sple; pk-sple; pkM; pk; sple", "protein_names_uniprotkb": "Protein prickle; Protein spiny legs", "protein_names_refseq": "CG11084-PA; pk-PA; prickle, isoform A; prickle-spiny legs; prickle-spiny-legs; spiny leg", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); progressive myoclonus epilepsy 1B (Disease Ontology:DOID:0111448); velocardiofacial syndrome (Disease Ontology:DOID:12583); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dme:Dmel_CG11084); (R-DME-350368); (R-DME-350369); (R-DME-350376); (R-DME-350411); (R-DME-350480); (R-DME-450728); (R-DME-4608870)", "pathway_count": 8, "publication_count": 22, "publication_id_list": "10469646;10485852;10570971;10731132;11301004;11874917;12015986;12537572;12642492;12756182;12941693;14636582;15269282;15306567;15556868;15937478;16469972;18701542;18723886;19576201;9694801;9716412", "class_list": "", "function": "Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A1Z6V4;A1Z6V8;Q9N9H6;Q9U5X0;Q9U5X1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0045184 establishment of protein localization;GO:0045773 positive regulation of axon extension;GO:0001738 morphogenesis of a polarized epithelium;GO:0007163 establishment or maintenance of cell polarity;GO:0045185 maintenance of protein location", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "A1Z6W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z8N1-1", "uniprot_id": "TRE11_DROME", "mass": 95188.0, "length": 857, "protein_name": "Trehalose transporter 1", "gene_name": "Tret1", "organism": "Fruit fly", "refseq_name": "trehalose transporter 1-1, isoform A", "refseq_ac": "NP_610693", "gene_names_uniprotkb": "Tret1; CG30035; Tret1-1", "gene_names_refseq": "CG30035; CG7797; CG7801; DmTret1-1; Dmel\\CG30035; Tre T1; Tret-1; Tret1-1; tret", "protein_names_uniprotkb": "Trehalose transporter 1; DmTret1-1; Facilitated trehalose transporter Tret1-1", "protein_names_refseq": "CG30035-PA; Tret1-1-PA; trehalose transporter 1-1, isoform A; trehalose transporter 1; trehalose transporter", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30035); (R-DME-189200)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537572;18327897;20035867;26235423;34032568", "class_list": "", "function": "Low-capacity facilitative transporter for trehalose (PubMed:20035867, PubMed:34032568). Can also transport glucose (PubMed:34032568). Does not transport maltose, sucrose, lactose or fructose (PubMed:20035867, PubMed:34032568). Mediates the bidirectional transfer of trehalose (PubMed:20035867). Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph (PubMed:20035867). Required in glial cells of the blood brain barrier to fuel glycolysis but not required in neurons (PubMed:26235423). Neurons rely on the citric acid cycle for their energy needs and utilise alanine and lactate, by-products of glial cell glycolysis released into the hemolymph, as fuel (PubMed:26235423). Increased expression in glial cells of the blood brain barrier during starvation and increased cell surface localization enhances carbohydrate uptake to protect the central nervous system from restricted nutrient availability (PubMed:34032568)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A9ZSY5;Q6NQZ8;Q86P59", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0015574 trehalose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031982 vesicle", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0055085 transmembrane transport;GO:0015771 trehalose transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A1Z8N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z9E2-1", "uniprot_id": "LIN54_DROME", "mass": 100022.0, "length": 950, "protein_name": "Protein lin-54 homolog", "gene_name": "mip120", "organism": "Fruit fly", "refseq_name": "Myb-interacting protein 120, isoform A", "refseq_ac": "NP_610879", "gene_names_uniprotkb": "mip120; CG6061; Dmel\\CG6061; Dmel_CG6061; MIP120; Mip120; l(3)L4569; p120", "gene_names_refseq": "CG6061; Dmel\\CG6061; MIP120; Mip120; l(3)L4569; mip120; p120", "protein_names_uniprotkb": "Protein lin-54 homolog; Myb complex protein of 120 kDa", "protein_names_refseq": "CG6061-PA; Myb-interacting protein 120, isoform A; mip120-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6061); (R-DME-1538133)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12490953;12537568;12537572;12537573;12537574;15256498;15479636;15545624;16110336;17569856;17569867;18316477;25589440;26109356;26109357", "class_list": "", "function": "Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIF2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0070176 DRM complex;GO:0005634 nucleus;GO:0000785 chromatin;GO:0031523 Myb complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "A1Z9E2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z9G2-1", "uniprot_id": "SYF1_DROME", "mass": 103327.0, "length": 883, "protein_name": "Pre-mRNA-splicing factor syf1 homolog", "gene_name": "fand", "organism": "Fruit fly", "refseq_name": "fandango", "refseq_ac": "NP_610891", "gene_names_uniprotkb": "fand; CG6197; fas", "gene_names_refseq": "CG6197; Dmel\\CG6197; Fand; Prp5; XAB2; Xab2; fand; fas; l(2)05488; l(2)5488", "protein_names_uniprotkb": "Pre-mRNA-splicing factor syf1 homolog; Pre-mRNA-splicing factor fandango; Protein faint sausage", "protein_names_refseq": "CG6197-PA; complementation group 7; faint sausage; fand-PA; fandango", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6197); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-72163)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10502111;10731132;12537572;24755291;28087625", "class_list": "", "function": "Subunit of the NTC(Nineteen)/Prp19 complex, which is part of the spliceosome (PubMed:24755291, PubMed:28087625). The complex participates in spliceosome assembly, its remodeling and is required for efficient spliceosome activation (PubMed:24755291, PubMed:28087625). Essential for efficient pre-mRNA splicing (PubMed:24755291, PubMed:28087625). In embryos, efficient pre-mRNA splicing of zygotic transcripts is essential during dynamic cellular processes that require rapid division and/or dramatic changes in gene expression such as blastoderm cellularization, tracheal branching morphogenesis, Malpighian morphogenesis and epidermal development (PubMed:10502111, PubMed:24755291, PubMed:28087625). Part of its role in promoting embryo tracheal development is also due to specifically splicing bnl transcripts which results in the activation of the BNL-FGF pathway (PubMed:28087625)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C3KGI3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0071014 post-mRNA release spliceosomal complex;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0002009 morphogenesis of an epithelium;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A1Z9G2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1Z9P3-3", "uniprot_id": "SHRM_DROME", "mass": 172713.0, "length": 1576, "protein_name": "Protein Shroom", "gene_name": "Shrm", "organism": "Fruit fly", "refseq_name": "shroom, isoform D", "refseq_ac": "NP_001097307", "gene_names_uniprotkb": "Shrm; CG34379; Shroom", "gene_names_refseq": "CG13942; CG13944; CG34379; CG8603; Dmel\\CG34379; Shrm; Shrooom; dShrm; dmShroom; shrm", "protein_names_uniprotkb": "Protein Shroom", "protein_names_refseq": "CG34379-PD; Shrm-PD; shroom, isoform D; shroom", "tax_id": 7227, "disease": "chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dme:Dmel_CG34379)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;16615870;16684770;18327897;20549743;22493320;24535826", "class_list": "", "function": "Binds to Rho-kinase Rok and targets it to the apical cell cortex where it mediates apical constriction (PubMed:20549743, PubMed:22493320). During embryogenic axis elongation, required for the localization to adherens junctions and the establishment of planar polarization of both Rho-kinase Rok and myosin regulatory light chain sqh (PubMed:24535826). May be involved in the assembly of microtubule arrays during cell elongation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A1Z9P2;Q3KN39;Q7K1B1", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A1Z9P3-3", "record_type": "protein" }, { "uniprot_canonical_ac": "A1ZAW5-1", "uniprot_id": "ICLN_DROME", "mass": 23743.0, "length": 215, "protein_name": "Methylosome subunit pICln", "gene_name": "icln", "organism": "Fruit fly", "refseq_name": "icln", "refseq_ac": "NP_611237", "gene_names_uniprotkb": "icln; CG4924", "gene_names_refseq": "CG4924; Dmel\\CG4924; icln; pICln", "protein_names_uniprotkb": "Methylosome subunit pICln", "protein_names_refseq": "CG4924-PA; icln-PA; icln", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4924)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;23333303", "class_list": "", "function": "Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U3W1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005681 spliceosomal complex;GO:0034709 methylosome", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:0006821 chloride transport;GO:0000387 spliceosomal snRNP assembly;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1ZAW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1ZB64-1", "uniprot_id": "BOM06_DROME", "mass": 4190.0, "length": 40, "protein_name": "Bomanin Short 6", "gene_name": "BomS6", "organism": "Fruit fly", "refseq_name": "bomanin short 6", "refseq_ac": "NP_788402", "gene_names_uniprotkb": "BomS6; Bom068; CG15068", "gene_names_refseq": "Bom068; BomS6; CG15068; CT34939; Dmel\\CG15068", "protein_names_uniprotkb": "Bomanin Short 6; Bomanin-068", "protein_names_refseq": "BomS6-PA; CG15068-PA; bomanin 068; bomanin S6; bomanin short 6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15068)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;25915418;29920489", "class_list": "", "function": "Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489). The strength of antimicrobial activity appears to correlate with the overall level of expression (PubMed:29920489)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F2FBA7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0010046 response to mycotoxin", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1ZB64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A1ZBR5-1", "uniprot_id": "AKTP2_DROME", "mass": 30805.0, "length": 266, "protein_name": "Protein crossbronx-like", "gene_name": "CG16894", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_611455", "gene_names_uniprotkb": "CG16894", "gene_names_refseq": "CG16894; Dmel\\CG16894", "protein_names_uniprotkb": "Protein crossbronx-like", "protein_names_refseq": "CG16894-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16894)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T8U2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1ZBR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2VEI2-1", "uniprot_id": "MICU1_DROME", "mass": 60344.0, "length": 525, "protein_name": "Calcium uptake protein 1 homolog, mitochondrial", "gene_name": "MICU1", "organism": "Fruit fly", "refseq_name": "mitochondrial calcium uptake 1, isoform B", "refseq_ac": "NP_001097110", "gene_names_uniprotkb": "MICU1; CG4495", "gene_names_refseq": "CG4495; Dmel\\CG4495; MICU1; micu1", "protein_names_uniprotkb": "Calcium uptake protein 1 homolog, mitochondrial; Mitochondrial calcium uptake 1", "protein_names_refseq": "CG4495-PB; MICU1-PB; mitochondrial calcium uptake 1, isoform B", "tax_id": 7227, "disease": "myopathy with extrapyramidal signs (Disease Ontology:DOID:0111335); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG4495); (R-DME-8949215); (R-DME-8949664)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;27568554", "class_list": "", "function": "Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains (PubMed:27568554). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (By similarity). At higher calcium levels, calcium-binding to MICU1 induces a conformational change that weakens MCU-MICU1 interactions and moves MICU1 away from the pore, allowing calcium permeation through the MCU channel (By similarity). Also required to protect against manganese toxicity by preventing manganese uptake by MCU (By similarity). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult (PubMed:27568554)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VM38", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:1990246 uniplex complex", "go_biological_process": "GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0051561 positive regulation of mitochondrial calcium ion concentration;GO:0007615 anesthesia-resistant memory;GO:0072375 medium-term memory", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2VEI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A2VEY9-1", "uniprot_id": "APP_DROME", "mass": 75008.0, "length": 693, "protein_name": "Palmitoyltransferase app", "gene_name": "app", "organism": "Fruit fly", "refseq_name": "approximated, isoform L", "refseq_ac": "NP_001137936", "gene_names_uniprotkb": "app; APP; App; CG17144; CG42318; CG5620; CR32097; Dmel\\CG42318; Dmel_CG42318", "gene_names_refseq": "APP; App; CG17144; CG42318; CG5620; CR32097; Dmel\\CG42318; app", "protein_names_uniprotkb": "Palmitoyltransferase app; 2.3.1.225; Protein approximated", "protein_names_refseq": "CG42318-PL; app-PL; approximated, isoform L; approximated", "tax_id": 7227, "disease": "syndromic X-linked intellectual disability Raymond type (Disease Ontology:DOID:0060824)", "pathway": " (dme:Dmel_CG42318); (R-DME-9648002)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18719403;18804377;25589440;26109356;26109357;27692068", "class_list": "", "function": "Palmitoylates Dlish which is required for the apical cell cortex localization, total cellular level and full activity of dachs., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0A6;M9NDQ1;M9NF95", "ec_number_list": "2.3.1.225;3.6.5.2", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0007389 pattern specification process;GO:0048104 establishment of body hair or bristle planar orientation;GO:0001737 establishment of imaginal disc-derived wing hair orientation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A2VEY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3RLR1-1", "uniprot_id": "TALAA_DROME", "mass": 3855.0, "length": 32, "protein_name": "Peptide tarsal-less AA", "gene_name": "tal-AA", "organism": "Fruit fly", "refseq_name": "tarsal-less AA", "refseq_ac": "NP_001138049", "gene_names_uniprotkb": "tal-AA; CG42387; pri; tal", "gene_names_refseq": "CG42387; Dm4; Dm_3R:52381; Dmel\\CG42387; ORF AA; ORF4; Pep4; pri; tal-AA; tal", "protein_names_uniprotkb": "Peptide tarsal-less AA; Peptide polished rice 4", "protein_names_refseq": "CG42387-PA; tal-AA-PA; tarsal-less AA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42387)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;17439302;17486114;18801356;20647469;21527259;21682860;25344753;26383956", "class_list": "", "function": "One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes (PubMed:17439302, PubMed:17486114, PubMed:21527259, PubMed:25344753). Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation (PubMed:17439302, PubMed:18801356, PubMed:21527259). Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development (PubMed:20647469, PubMed:21527259, PubMed:26383956). This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator (PubMed:26383956). Also enhances interaction of Ubr3 with Diap1 (PubMed:26383956). Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway (PubMed:18801356, PubMed:21527259, PubMed:21682860). Essential for denticle formation and may have a role in the developmental timing of trichome differentiation (PubMed:17486114, PubMed:25344753). Essential for the development of taenidial folds in the trachea (PubMed:17486114)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007015 actin filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A3RLR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O61267-1", "uniprot_id": "LOK_DROME", "mass": 54261.0, "length": 476, "protein_name": "Ovarian-specific serine/threonine-protein kinase Lok", "gene_name": "lok", "organism": "Fruit fly", "refseq_name": "loki, isoform B", "refseq_ac": "NP_477218", "gene_names_uniprotkb": "lok; 10895; 38B.4; CG10895; CHK-2; CHK2; Chk2; DChk2; DmCHk2; DmChk2; Dmchk2; Dmel\\CG10895; Dmel_CG10895; Dmnk-L; Dmnk-S; Dmnk; Loki; Lok; MNK; Mnk; chk-2; chk2; chk; loki; lok; mnk", "gene_names_refseq": "10895; 38B.4; CG10895; CHK-2; CHK2; Chk2; DmCHk2; DmChk2; Dmchk2; Dmel\\CG10895; Dmnk-L; Dmnk-S; Dmnk/DChk2; Dmnk; LOKI/CHK2; Loki; Lok; MNK; Mnk; chk-2; chk2/lok; chk2; chk; loki; lok; mnk", "protein_names_uniprotkb": "Ovarian-specific serine/threonine-protein kinase Lok; 2.7.11.1; Protein loki; dMNK", "protein_names_refseq": "CG10895-PB; checkpoint kinase 2; drosophila maternal nuclear kinase; localized ovarian kinase; lok-PB; loki, isoform B", "tax_id": 7227, "disease": "female breast cancer (Disease Ontology:DOID:0050671); Li-Fraumeni syndrome 2 (Disease Ontology:DOID:0111504); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); male breast cancer (Disease Ontology:DOID:1614); embryonal carcinoma (Disease Ontology:DOID:3308); osteosarcoma (Disease Ontology:DOID:3347); seminoma (Disease Ontology:DOID:4440); congestive heart failure (Disease Ontology:DOID:6000); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG10895); (R-DME-5693565); (R-DME-6804756); (R-DME-69473); (R-DME-69541); (R-DME-69601); (R-DME-75035)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;34644293;9507063", "class_list": "", "function": "May have a role in germline establishment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O61268;P91876;Q8SZS3", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;5.6.1.8;2.7.11.11;3.1.3.48;2.7.11.23;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;2.7.11.39", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O61267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A8JNV4-1", "uniprot_id": "BL1S3_DROME", "mass": 16070.0, "length": 144, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 3", "gene_name": "Blos3", "organism": "Fruit fly", "refseq_name": "biogenesis of lysosome-related organelles complex 1, subunit 3", "refseq_ac": "NP_001097640", "gene_names_uniprotkb": "Blos3; CG34255", "gene_names_refseq": "BLOS3; Blos3; CG34255; Dm Blos3; Dmel\\CG34255; NP_001097640; blos3", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 3; BLOC-1 subunit 3", "protein_names_refseq": "BLOC-1 subunit 3; Blos3-PA; CG34255-PA; biogenesis of lysosome-related organelles complex 1, subunit 3", "tax_id": 7227, "disease": "Hermansky-Pudlak syndrome 8 (Disease Ontology:DOID:0060546)", "pathway": " (dme:Dmel_CG34255)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;20015953", "class_list": "", "function": "Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0008057 eye pigment granule organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A8JNV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O17445-1", "uniprot_id": "RL15_DROME", "mass": 24325.0, "length": 204, "protein_name": "Large ribosomal subunit protein eL15", "gene_name": "RpL15", "organism": "Fruit fly", "refseq_name": "ribosomal protein L15, isoform A", "refseq_ac": "NP_001015155", "gene_names_uniprotkb": "RpL15; 80Fi; CG17420; CG40199; DmRpL15; Dmel\\CG17420; Dmel_CG17420; L15e; L15; RPL15; Rpl15; ZITI; l(3)80Fi; l(3)Lh2; l2; lethal 2; rpL15; rpl15", "gene_names_refseq": "80Fi; CG17420; CG40199; DmRpL15; Dmel\\CG17420; L15e; L15; RPL15; RpL15; Rpl15; l(3)80Fi; l(3)Lh2; l2; lethal 2; rpL15; rpl15", "protein_names_uniprotkb": "Large ribosomal subunit protein eL15; 60S ribosomal protein L15", "protein_names_refseq": "CG17420-PA; RpL15-PA; lethal (3) 80Fi; lethal 2; lethal2; ribosomal L15; ribosomal protein L15, isoform A", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 12 (Disease Ontology:DOID:0111882)", "pathway": " (dme:Dmel_CG17420); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8Y561;Q7PL86;Q9W5N1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O17445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B4F7L9-1", "uniprot_id": "WDY_DROME", "mass": 121814.0, "length": 1069, "protein_name": "WD repeat-containing protein on Y chromosome", "gene_name": "WDY", "organism": "Fruit fly", "refseq_name": "WD40 Y", "refseq_ac": "NP_001303588", "gene_names_uniprotkb": "WDY; CG41020", "gene_names_refseq": "CG40245; CG40449; CG40551; CG40583; CG41020; CG45799; Dmel\\CG45799; FBgn0267449; WDY", "protein_names_uniprotkb": "WD repeat-containing protein on Y chromosome; WD40 Y", "protein_names_refseq": "CG45799-PC; WD40 Y; WDY-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG45799)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;18660539;19011613", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8QI03;A8QI24;A8QI78;Q5BHX3;Q7PLH6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B4F7L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B6VQA1-1", "uniprot_id": "DIMM_DROME", "mass": 40980.0, "length": 390, "protein_name": "Protein dimmed", "gene_name": "dimm", "organism": "Fruit fly", "refseq_name": "dimmed, isoform B", "refseq_ac": "NP_001260674", "gene_names_uniprotkb": "dimm; CG8667; DIMM; Dimm; Dmel\\CG8667; Dmel_CG8667; Mistr; bHLHa16; c929; dim", "gene_names_refseq": "CG8667; DIMM; Dimm; Dmel\\CG8667; Mistr; bHLHa16; c929; dimm; dim", "protein_names_uniprotkb": "Protein dimmed", "protein_names_refseq": "CG8667-PB; dimm-PB; dimmed, isoform B; dimmed; mist 1-related", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8667)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10731132;10973473;12537568;12537572;12537573;12537574;12642483;15081360;15748845;16110336;16651547;16870731;17569856;17569867;17967878;20045330;25589440;26109356;26109357", "class_list": "", "function": "Transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate. Acts as a master regulator of common NS functions such as Phm expression and neuropeptide production. Plays a role as a regulator of peptide-containing large dense-core vesicle (LDCV) production and peptidergic cell differentiation. Controls transcription of FMRFamide in Tv neuronal cells and Fur1 in Ap-let cells (Tvb and dorsal apterous cells). Also required for up-regulation of Phm in Tv and Ap-let cells, and expression of three neuropeptide genes, Ms, FMRFamide and Lk. Influences both regulated and constitutive secretory activity in neuroendocrine cells at embryonic and postembryonic level. Loss of function studies show reduced cellular levels of various neuropeptides and neuropeptide biosynthetic enzymes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q0IGR9;Q9VID2", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002793 positive regulation of peptide secretion;GO:0006355 regulation of DNA-templated transcription;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "B6VQA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B7TB45-1", "uniprot_id": "SPZ2_DROME", "mass": 100315.0, "length": 886, "protein_name": "Neurotrophin 1", "gene_name": "NT1", "organism": "Fruit fly", "refseq_name": "neurotrophin 1, isoform D", "refseq_ac": "NP_001163348", "gene_names_uniprotkb": "NT1; CG18318; CG32242; CG32244; CG42576; CT30097; DNT1; Dmel\\CG42576; Dmel_CG42576; SPZ2; Spz-2; Spz2; Spz; dNT1; spz2", "gene_names_refseq": "CG18318; CG32242; CG32244; CG42576; CT30097; DNT1; Dmel\\CG42576; NT1; SPZ2; Spz-2; Spz2; Spz; dNT1; spz2", "protein_names_uniprotkb": "Neurotrophin 1; Neurotrophic factor 1; Protein spaetzle 2; Protein spatzle 2", "protein_names_refseq": "CG42576-PD; NT1-PD; drosophila Neurotrophin1; neurotrophin 1, isoform D; spatzle 2; spatzle2; spz2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42576)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11536362;12537568;12537572;12537573;12537574;16110336;17569856;17569867;19018662;22022271;23892553;24124519;25589440;26109356;26109357", "class_list": "", "function": "Neurotrophin which may function as a ligand for the Toll-related receptors Toll-7 and Tollo (PubMed:22022271, PubMed:23892553). Binds to Toll-7 and probably acts as its ligand in promoting motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons (PubMed:19018662). In larvae, involved in the negative regulation of the tracheal immune response to bacterial infection perhaps by acting as a ligand for the Toll-related receptor Tollo (PubMed:22022271). May be involved in the normal development of specific neurons at the neuromuscular junction (PubMed:24124519)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8IRB0", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0048018 receptor ligand activity;GO:0005121 Toll binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0043524 negative regulation of neuron apoptotic process;GO:0008063 Toll signaling pathway;GO:0008045 motor neuron axon guidance;GO:0021556 central nervous system formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "B7TB45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B7Z031-1", "uniprot_id": "PESTE_DROME", "mass": 62252.0, "length": 555, "protein_name": "Protein peste", "gene_name": "pes", "organism": "Fruit fly", "refseq_name": "peste, isoform C", "refseq_ac": "NP_001137808", "gene_names_uniprotkb": "pes; CG7228; Dmel\\CG7228; Dmel_CG7228; Peste; Pes", "gene_names_refseq": "CG7228; Dmel\\CG7228; Peste; Pes; pes", "protein_names_uniprotkb": "Protein peste", "protein_names_refseq": "CG7228-PC; pes-PC; peste, isoform C; peste", "tax_id": 7227, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); morbid obesity (Disease Ontology:DOID:11981); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dme:Dmel_CG7228); (R-DME-114608); (R-DME-1236973); (R-DME-434313); (R-DME-6798695)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16020694;16110336;17569856;17569867;21948708;25589440;26109356;26109357", "class_list": "", "function": "(Microbial infection) Plays a role in mycobacterial infection. Mediates infection by M.fortuitum and uptake of M.smegmatis., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXU4;Q9VLU8", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "B7Z031-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B7Z0I7-1", "uniprot_id": "SPN1_DROME", "mass": 41504.0, "length": 351, "protein_name": "Snurportin-1", "gene_name": "Snup", "organism": "Fruit fly", "refseq_name": "snurportin", "refseq_ac": "NP_001137877", "gene_names_uniprotkb": "Snup; CG42303", "gene_names_refseq": "CG1247; CG32297; CG42303; Dmel\\CG42303; Snup; dSNUP", "protein_names_uniprotkb": "Snurportin-1", "protein_names_refseq": "CG42303-PA; Snup-PA; snurportin", "tax_id": 7227, "disease": "autosomal recessive limb-girdle muscular dystrophy type 29 (Disease Ontology:DOID:0061134); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274)", "pathway": " (dme:Dmel_CG42303)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;23885126", "class_list": "", "function": "Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0030620 U2 snRNA binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0015030 Cajal body;GO:0071254 cytoplasmic U snRNP body", "go_biological_process": "GO:0061015 snRNA import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B7Z0I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O18400-1", "uniprot_id": "PITX_DROME", "mass": 53217.0, "length": 509, "protein_name": "Pituitary homeobox homolog Ptx1", "gene_name": "Ptx1", "organism": "Fruit fly", "refseq_name": "Ptx1, isoform A", "refseq_ac": "NP_733410", "gene_names_uniprotkb": "Ptx1; CG1447; D-Ptx1; Dmel\\CG1447; Dmel_CG1447; Ptx; ptx1", "gene_names_refseq": "CG1447; D-Ptx1; Dmel\\CG1447; Ptx1; Ptx; ptx1", "protein_names_uniprotkb": "Pituitary homeobox homolog Ptx1; D-PTX1", "protein_names_refseq": "CG1447-PA; Ptx1, isoform A; Ptx1-PA", "tax_id": 7227, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); anterior segment dysgenesis (Disease Ontology:DOID:0060648); anterior segment dysgenesis 1 (Disease Ontology:DOID:0080606); anterior segment dysgenesis 4 (Disease Ontology:DOID:0080609); Axenfeld-Rieger syndrome type 1 (Disease Ontology:DOID:0110120); cataract 11 multiple types (Disease Ontology:DOID:0110249); cataract 9 multiple types (Disease Ontology:DOID:0110266); ring dermoid of cornea (Disease Ontology:DOID:0111548); clubfoot (Disease Ontology:DOID:11836); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); glaucoma (Disease Ontology:DOID:1686); cataract (Disease Ontology:DOID:83); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dme:Dmel_CG1447)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9431811", "class_list": "", "function": "Appears to control physiological cell functions rather than pattern formation during embryogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VA26", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O18400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B7Z0W9-1", "uniprot_id": "OTOP_DROME", "mass": 169751.0, "length": 1576, "protein_name": "Proton channel OtopLc", "gene_name": "OtopLc", "organism": "Fruit fly", "refseq_name": "Otopetrin-like c, isoform D", "refseq_ac": "NP_001138160", "gene_names_uniprotkb": "OtopLc; CG42265", "gene_names_refseq": "CG15776; CG15777; CG17758; CG42265; Dmel\\CG42265; OtopLC; OtopLc; dmOTOPLc; dm_OtopLc; otoplc", "protein_names_uniprotkb": "Proton channel OtopLc; DmOtopLc; Otopetrin-Lc", "protein_names_refseq": "CG42265-PD; OtopLc-PD; Otopetrin-like c, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42265)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;29371428", "class_list": "", "function": "Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes., [UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 4, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "A0A0S0X6R3;B7Z0X0", "ec_number_list": "", "go_molecular_function": "GO:0015252 proton channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B7Z0W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HK94-1", "uniprot_id": "Y5078_DROME", "mass": 18836.0, "length": 163, "protein_name": "Uncharacterized protein CG45078", "gene_name": "CG45078", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_731506", "gene_names_uniprotkb": "CG45078", "gene_names_refseq": "CG45078; CG6544; Dmel\\CG45078", "protein_names_uniprotkb": "Uncharacterized protein CG45078", "protein_names_refseq": "CG45078-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG45078)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95S18;Q9VGX1;Q9VGX2;Q9VGX3;Q9Y0F9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C0HK94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HK95-1", "uniprot_id": "FAU_DROME", "mass": 14371.0, "length": 131, "protein_name": "Protein anoxia up-regulated", "gene_name": "fau", "organism": "Fruit fly", "refseq_name": "fau", "refseq_ac": "NP_731505", "gene_names_uniprotkb": "fau; CG45077", "gene_names_refseq": "BcDNA:HL07933; CG45077; CG6544; Dmel\\CG45077; Fau; fau", "protein_names_uniprotkb": "Protein anoxia up-regulated", "protein_names_refseq": "CG45077-PA; fau-PA; fau", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG45077)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;40245499;9878744", "class_list": "", "function": "Plays an important role in the regulation of tissue responsiveness to oxygen deprivation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q95S18;Q9VGX1;Q9VGX2;Q9VGX3;Q9Y0F9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0034059 response to anoxia", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "C0HK95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HK98-1", "uniprot_id": "SC1A_DROME", "mass": 20395.0, "length": 185, "protein_name": "Peptidoglycan-recognition protein SC1a", "gene_name": "PGRP-SC1a", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein SC1a", "refseq_ac": "NP_610407", "gene_names_uniprotkb": "PGRP-SC1a; CG14746", "gene_names_refseq": "CG14746; Dmel\\CG14746; PGRP SC; PGRP-SC1A; PGRP-SC1a; PGRP-SC1; PGRP-SC; pgrp-sc1; pgrp-sc; picky", "protein_names_uniprotkb": "Peptidoglycan-recognition protein SC1a; 3.5.1.28", "protein_names_refseq": "CG14746-PA; PGRP-SC1a-PA; Peptidoglycan-recognition protein-SC1a precursor; peptidoglycan recognition protein SC1a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14746); (dme:Dmel_CG8577); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537572;14738318;16120803", "class_list": "", "function": "N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJ78;Q2XY86;Q70PU9;Q70PV0;Q95SQ9;Q9V3B7", "ec_number_list": "3.2.1.17;1.1.1.42;3.5.1.28;3.2.1.14;3.5.3.1;4.1.2.13;3.1.3.48;1.16.3.1;2.7.1.35;2.3.2.5;3.4.19.9;3.4.24.-;2.7.10.2;3.6.1.5;3.5.1.3;3.3.2.6;3.5.4.5;5.4.2.2;3.4.17.13;3.2.1.-", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0050766 positive regulation of phagocytosis;GO:0009253 peptidoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "C0HK98-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HK99-1", "uniprot_id": "SC1B_DROME", "mass": 20395.0, "length": 185, "protein_name": "Peptidoglycan-recognition protein SC1b", "gene_name": "PGRP-SC1b", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein SC1b, isoform B", "refseq_ac": "NP_001286209", "gene_names_uniprotkb": "PGRP-SC1b; CG8577", "gene_names_refseq": "CG8577; CT8705; Dmel\\CG8577; PGRP SC; PGRP-SC1B; PGRP-SC1b; PGRP-SC1; PGRP-SC; SC1B; pgrp-sc1; pgrp-sc", "protein_names_uniprotkb": "Peptidoglycan-recognition protein SC1b; 3.5.1.28", "protein_names_refseq": "CG8577-PB; PGRP-SC1b-PB; Peptidoglycan-recognition protein-SC1b precursor; peptidoglycan recognition protein SC1b, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14746); (dme:Dmel_CG8577); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;11106397;12496260;12537569;12537572;14738318", "class_list": "", "function": "N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN) (PubMed:11106397, PubMed:12496260). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments (PubMed:12496260). Has no direct bacteriolytic activity (PubMed:12496260)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LEX8;B5RJ78;Q2XY86;Q70PU9;Q70PV0;Q95SQ9;Q9V3B7", "ec_number_list": "3.2.1.17;1.1.1.42;3.5.1.28;3.2.1.14;3.5.3.1;4.1.2.13;3.1.3.48;1.16.3.1;2.7.1.35;2.3.2.5;3.4.19.9;3.4.24.-;2.7.10.2;3.6.1.5;3.5.1.3;3.3.2.6;3.5.4.5;5.4.2.2;3.4.17.13;3.2.1.-", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0009253 peptidoglycan catabolic process;GO:0002814 negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "C0HK99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKA2-1", "uniprot_id": "TRYDT_DROME", "mass": 25680.0, "length": 253, "protein_name": "Trypsin delta", "gene_name": "deltaTry", "organism": "Fruit fly", "refseq_name": "deltaTrypsin", "refseq_ac": "NP_523694", "gene_names_uniprotkb": "deltaTry; CG12351", "gene_names_refseq": "CG12351; DeltaTry; DmDeltaTry; Dmel\\CG12351; SP213; Try; deltaTry; delta; endo-I", "protein_names_uniprotkb": "Trypsin delta; 3.4.21.4", "protein_names_refseq": "CG12351-PA; deltaTry-PA; deltaTrypsin; endoproteinase I", "tax_id": 7227, "disease": "amelogenesis imperfecta type 2A1 (Disease Ontology:DOID:0110057); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG12351); (dme:Dmel_CG30028); (dme:Dmel_CG30031)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10486967;10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G7H855;P42276;P42277;Q8SXZ4;Q9V5Y4", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "C0HKA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKF8-1", "uniprot_id": "SER2_DROME", "mass": 28469.0, "length": 265, "protein_name": "Serine protease 2", "gene_name": "Jon99Ciii", "organism": "Fruit fly", "refseq_name": "jonah 99Ciii, isoform B", "refseq_ac": "NP_001287598", "gene_names_uniprotkb": "Jon99Ciii; 99Calpha; CG15519; CG31362; Dmel\\CG31362; Dmel_CG31362; Jon99B; Jon99C1; Jon99C2; Jon99Calphaii; Jon99Calpha; Jon99Cbetaiii; Jon99Cbeta; Jon99C; JonC; SER2; SP143; Ser2; Ser5; Ser99Db", "gene_names_refseq": "99Calpha; CG15519; CG31362; Dmel\\CG31362; Jon99B; Jon99C1; Jon99C2; Jon99Calphaii; Jon99Calpha; Jon99Cbetaiii; Jon99Cbeta; Jon99Ciii; Jon99C; JonC; SER2; SP143; Ser2; Ser5; Ser99Db", "protein_names_uniprotkb": "Serine protease 2; 3.4.21.-; Protein Jonah 99Ciii", "protein_names_refseq": "CG31362-PB; Jon99Ciii-PB; jonah 99C alpha; jonah 99C beta; jonah 99Ciii, isoform B; serine protease 2; serine protease 5", "tax_id": 7227, "disease": "pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (dme:Dmel_CG31034); (dme:Dmel_CG31362)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2469005;25589440;26109356;26109357", "class_list": "", "function": "Major function may be to aid in digestion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17205;Q23988;Q9VAD9;Q9VAE0", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "C0HKF8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C0HKQ7-1", "uniprot_id": "CECA1_DROME", "mass": 6771.0, "length": 63, "protein_name": "Cecropin-A1", "gene_name": "CecA1", "organism": "Fruit fly", "refseq_name": "cecropin A1", "refseq_ac": "NP_524588", "gene_names_uniprotkb": "CecA1; CG1365", "gene_names_refseq": "CEC; CG1365; Cec A1; Cec-A1; CecA1; CecA2; CecA; Cec; DIM 25; Dmel\\CG1365; ce-A1; cec A; cecA1; cecA; cecropin; cec; crpA1", "protein_names_uniprotkb": "Cecropin-A1", "protein_names_refseq": "CG1365-PA; CecA1-PA; Cecropin-A1/A2 precursor; CecropinA; cecropin A1; cecropin A; cecropin-A1; cecropinA1; cecropins", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1365); (dme:Dmel_CG1367)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;11266367;12537572;16510152;2104802;2390977;9335607;9553148;9725836", "class_list": "", "function": "Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria (PubMed:11266367, PubMed:2390977). Functions in the imd/NF-kappa-B (Imd) epithelial and humoral immune response to Gram-negative bacteria (PubMed:11266367)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DN02;B3DN08;O16815;O16816;O16817;O16818;O16819;O16820;O16821;O61275;O61276;O61277;O61279;O62590;P14954;P82449", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "C0HKQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O01404-1", "uniprot_id": "PHM_DROME", "mass": 40564.0, "length": 365, "protein_name": "Peptidylglycine alpha-hydroxylating monooxygenase", "gene_name": "Phm", "organism": "Fruit fly", "refseq_name": "Peptidylglycine-alpha-hydroxylating monooxygenase, isoform A", "refseq_ac": "NP_477225", "gene_names_uniprotkb": "Phm; CG3832; Dmel\\CG3832; Dmel_CG3832; PHM; dPHM; lance-b; ll; phm", "gene_names_refseq": "CG3832; Dmel\\CG3832; PHM; Phm; dPHM; lance-b; ll; phm", "protein_names_uniprotkb": "Peptidylglycine alpha-hydroxylating monooxygenase; 1.14.17.3; dPHM", "protein_names_refseq": "CG3832-PA; Peptidylglycine-alpha-hydroxylating monooxygenase, isoform A; Phm-PA; lanceolate; lanceolote; peptidyl gycine alpha hydroxylating monooxygenase; peptidylglycine alpha-hydroxylating monooxygenase; peptidylglycine-alpha-hydroxylating monooxygenase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3832)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;10993678;11517257;12537568;12537569;12537572;12537573;12537574;16110336;16870731;17569856;17569867;25589440;26109356;26109357;40245499;9006979", "class_list": "", "function": "Monooxygenase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Produces an unstable peptidyl(2-hydroxyglycine) intermediate. C-terminal amidation of peptides is required for normal developmental transitions and for biosynthesis of secretory peptides throughout the life., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O01402;O01403;O01405;O01406;O01407;O01408;Q7JNH8;Q7JNH9;Q7JNI0;Q7JNI1;Q7JNI2;Q7JNI3;Q7JNI4", "ec_number_list": "1.14.17.3", "go_molecular_function": "GO:0004504 peptidylglycine monooxygenase activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0007320 insemination;GO:0007613 memory;GO:0006518 peptide metabolic process;GO:0009620 response to fungus;GO:0044719 regulation of imaginal disc-derived wing size", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O01404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E9NA96-1", "uniprot_id": "IR25A_DROME", "mass": 108122.0, "length": 947, "protein_name": "Ionotropic receptor 25a", "gene_name": "Ir25a", "organism": "Fruit fly", "refseq_name": "ionotropic receptor 25a, isoform C", "refseq_ac": "NP_001260049", "gene_names_uniprotkb": "Ir25a; 25a; CG15627; CT35778; DmelIR25a; Dmel\\CG15627; Dmel_CG15627; IR25a; ir25a", "gene_names_refseq": "25a; CG15627; CT35778; DmelIR25a; Dmel\\CG15627; IR25a; Ir25a; ir25a", "protein_names_uniprotkb": "Ionotropic receptor 25a", "protein_names_refseq": "CG15627-PC; Ir25a-PC; ionotropic receptor 25a, isoform C; ionotropic receptor 25a", "tax_id": 7227, "disease": "autosomal recessive spinocerebellar ataxia 18 (Disease Ontology:DOID:0080042)", "pathway": " (dme:Dmel_CG15627); (R-DME-399710); (R-DME-416993); (R-DME-438066); (R-DME-8849932)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;19135896;21220098;25589440;26109356;26109357;26580016;27126188;27161501;27656904", "class_list": "", "function": "Integral part of various neural sensory systems in the antenna that provide the neural basis for the response to environmental changes in temperature (thermosensation), humidity (hygrosensation) and odor detection (PubMed:21220098, PubMed:27161501, PubMed:27656904). Required for odor-evoked electrophysiological responses in multiple neuron classes in the antenna and is likely to function as part of an olfactory receptor complex with Ir76a and Ir76b (PubMed:21220098). Together with Ir21a and Ir93a, mediates the response of the larval dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27126188, PubMed:27161501, PubMed:27656904). Required in chordonotal organ neurons for behavioral synchronization to low-amplitude temperature cycles and mediates circadian clock resetting by temperature (PubMed:26580016). Together with Ir40a and Ir93a, mediates the response of the hydrosensory sacculus neurons to changes in relative humidity, and is required for dry detection and humidiy preference behavior (PubMed:27161501, PubMed:27656904)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0008066 glutamate receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0030424 axon;GO:0043204 perikaryon", "go_biological_process": "GO:0050907 detection of chemical stimulus involved in sensory perception;GO:0035249 synaptic transmission, glutamatergic;GO:0048511 rhythmic process;GO:0050804 modulation of chemical synaptic transmission;GO:0009649 entrainment of circadian clock", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "E9NA96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M9MRI4-1", "uniprot_id": "TRIM9_DROME", "mass": 80192.0, "length": 740, "protein_name": "E3 ubiquitin-protein ligase TRIM9", "gene_name": "Trim9", "organism": "Fruit fly", "refseq_name": "tripartite motif containing 9, isoform B", "refseq_ac": "NP_001188786", "gene_names_uniprotkb": "Trim9; CG31721", "gene_names_refseq": "Asap; CG13145; CG31721; CG6256; Dmel\\CG31721; TRIM9; Trim9; asap; cg31721; dTrim9", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM9; 2.3.2.27; Anomalies in sensory axon patterning protein; RING-type E3 ubiquitin transferase TRIM9; Tripartite motif containing protein 9; asap", "protein_names_refseq": "CG31721-PB; Trim9-PB; anomalies in sensory axon patterning; tripartite motif containing 9, isoform B", "tax_id": 7227, "disease": "Opitz GBBB syndrome (Disease Ontology:DOID:0080697)", "pathway": " (dme:Dmel_CG31721); (R-DME-983168)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537572;16434393;21338947;22084112;24746793;27743477", "class_list": "", "function": "E3 ubiquitin-protein ligase activity (By similarity). During embryonic and larval development, regulates the pattern of axonal projections of class IV nociceptive sensory neurons (C4da) downstream of netrin receptor fra (PubMed:21338947, PubMed:22084112). Regulates fine-scale topography of C4da axon terminals upon neuronal activity (PubMed:24746793). During eye development, consolidates the attachment of R8 photoreceptor growth cones to the target medulla layer, probably downstream of fra (PubMed:27743477)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86P21;Q9VKT3", "ec_number_list": "2.3.2.27;2.3.2.25;2.3.2.23;2.3.2.31;2.3.2.26;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0043204 perikaryon;GO:0043005 neuron projection;GO:0044295 axonal growth cone", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0090325 regulation of locomotion involved in locomotory behavior;GO:0048749 compound eye development;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "M9MRI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M9NE38-1", "uniprot_id": "JV_DROME", "mass": 215031.0, "length": 1912, "protein_name": "Protein javelin", "gene_name": "jv", "organism": "Fruit fly", "refseq_name": "javelin, isoform C", "refseq_ac": "NP_001246648", "gene_names_uniprotkb": "jv; CG32397", "gene_names_refseq": "CG32397; Dmel\\CG32397; anon-WO0138581.6; jv", "protein_names_uniprotkb": "Protein javelin", "protein_names_refseq": "CG32397-PC; javelin, isoform C; jv-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32397)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21930794", "class_list": "", "function": "Important for normal assembly of actin bundles during bristle formation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IQ69", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0030046 parallel actin filament bundle assembly;GO:0008407 chaeta morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "M9NE38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "M9PD06-1", "uniprot_id": "UBP32_DROME", "mass": 199010.0, "length": 1779, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 32", "gene_name": "Usp32", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Usp32; CG8334; Usp15", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 32; 3.4.19.12", "protein_names_refseq": "", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8334)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;24852371", "class_list": "", "function": "Deubiquitinating enzyme that acts as an inhibitor of mitophagy probably by counteracting the action of park. Possibly functions by hydrolyzing ubiquitin attached by park on target proteins, thereby reducing park's ability to drive mitophagy., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "M9PFQ1;M9PFZ0;M9PG46", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "M9PD06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46341-1", "uniprot_id": "A6_DROME", "mass": 44077.0, "length": 409, "protein_name": "Protein a6", "gene_name": "a6", "organism": "Fruit fly", "refseq_name": "a6, isoform B", "refseq_ac": "NP_001259141", "gene_names_uniprotkb": "a6; CG3771; Dmel\\CG3771; Dmel_CG3771; EG:9D2.3", "gene_names_refseq": "CG3771; Dmel\\CG3771; EG:9D2.3; a6", "protein_names_uniprotkb": "Protein a6", "protein_names_refseq": "CG3771-PB; a6, isoform B; a6-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3771)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10546111;10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W564", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0001700 embryonic development via the syncytial blastoderm", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O46341-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46051-1", "uniprot_id": "C4D14_DROME", "mass": 57481.0, "length": 507, "protein_name": "Probable cytochrome P450 4d14", "gene_name": "Cyp4d14", "organism": "Fruit fly", "refseq_name": "cytochrome P450 4d14, isoform A", "refseq_ac": "NP_652020", "gene_names_uniprotkb": "Cyp4d14; 4d14; CG3540; CYP4D14; Cyp4D14; Dmel\\CG3540; Dmel_CG3540; EG:152A3.2", "gene_names_refseq": "4d14; CG3540; CYP4D14; Cyp4D14; Cyp4d14; Dmel\\CG3540; EG:152A3.2", "protein_names_uniprotkb": "Probable cytochrome P450 4d14; 1.14.-.-; CYPIVD14", "protein_names_refseq": "CG3540-PA; Cyp4d14-PA; cytochrome P450 4d14, isoform A; cytochrome P450", "tax_id": 7227, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664)", "pathway": " (dme:Dmel_CG3540); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10731132;10731137;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O46051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O01382-1", "uniprot_id": "DRICE_DROME", "mass": 37363.0, "length": 339, "protein_name": "Caspase drICE", "gene_name": "Drice", "organism": "Fruit fly", "refseq_name": "death related ICE-like caspase", "refseq_ac": "NP_524551", "gene_names_uniprotkb": "Drice; CG7788; ICE", "gene_names_refseq": "CG7788; DRICE; Dmel\\CG7788; DrICE; DrIce; DriCE; Drice; Drive; ICE; Ice; caspase 3; crice; drICE; drIce; drice; ice", "protein_names_uniprotkb": "Caspase drICE; 3.4.22.-; Death related ICE-like caspase", "protein_names_refseq": "CG7788-PA; Drice-PA; Ice; caspase 3; caspase-3; death related ICE-like caspase; drice; interleukin-1beta-converting enzyme", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); brain glioma (Disease Ontology:DOID:0060108); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); traumatic brain injury (Disease Ontology:DOID:0081292); endometritis (Disease Ontology:DOID:1002); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); cryptorchidism (Disease Ontology:DOID:11383); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); spermatic cord torsion (Disease Ontology:DOID:11996); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); transitional cell carcinoma (Disease Ontology:DOID:2671); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); intermittent claudication (Disease Ontology:DOID:3669); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); intestinal disease (Disease Ontology:DOID:5295); kidney disease (Disease Ontology:DOID:557); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG7788); (R-DME-111459); (R-DME-111465); (R-DME-111469); (R-DME-140342); (R-DME-2028269); (R-DME-264870); (R-DME-3371378); (R-DME-351906); (R-DME-352238); (R-DME-418889); (R-DME-5218900); (R-DME-5357905); (R-DME-5675482); (R-DME-69416); (R-DME-75153); (R-DME-9758274)", "pathway_count": 17, "publication_count": 9, "publication_id_list": "10619023;10675329;10731132;12537569;12537572;18166655;21220123;25644603;9184225", "class_list": "", "function": "Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 57, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VAH1", "ec_number_list": "3.4.22.-;2.7.10.2;2.3.2.23;2.7.11.13;2.3.2.27;3.4.22.61;2.7.11.1;2.7.11.25;2.5.1.58;2.5.1.59", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0004197 cysteine-type endopeptidase activity;GO:1990525 BIR domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016322 neuron remodeling;GO:0006915 apoptotic process;GO:0097194 execution phase of apoptosis;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O01382-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O01666-1", "uniprot_id": "ATPG_DROME", "mass": 32871.0, "length": 297, "protein_name": "ATP synthase subunit gamma, mitochondrial", "gene_name": "ATPsyngamma", "organism": "Fruit fly", "refseq_name": "ATP synthase, gamma subunit, isoform A", "refseq_ac": "NP_524550", "gene_names_uniprotkb": "ATPsyngamma; ATPsyn-gamma; CG7610", "gene_names_refseq": "ATP-syn-gamma; ATPG_DROME; ATPG; ATPsyn-gamma; ATPsyn-gam; ATPsyngamma; CG7610; Dmel\\CG7610", "protein_names_uniprotkb": "ATP synthase subunit gamma, mitochondrial; F-ATPase gamma subunit", "protein_names_refseq": "ATP synthase gamma chain; ATP synthase subunit gamma; ATP synthase, gamma subunit, isoform A; ATP synthase-gamma chain; ATPsyn-gamma chain; ATPsyngamma-PA; ATPsynthase gamma; CG7610-PA; F0/F1 ATP synthase gamma; F1ATP synthase; catalytic core of F1 ATP synthase of complex V", "tax_id": 7227, "disease": "schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG7610); (R-DME-163210); (R-DME-8949613); (R-DME-9837999)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10071211;10731132;12537569;12537572", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3L6;Q0KHZ7;Q9VAH8", "ec_number_list": "", "go_molecular_function": "GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O01666-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O18335-1", "uniprot_id": "O18335_DROME", "mass": 24245.0, "length": 214, "protein_name": "Rab11, isoform A; Rab11, isoform B", "gene_name": "Rab11", "organism": "Fruit fly", "refseq_name": "Rab11, isoform B", "refseq_ac": "NP_477170", "gene_names_uniprotkb": "Rab11; AAF55850; CG5771; DRAB11; DRab11; Dm Rab11; DmRab11; Dmel\\CG5771; Dmel_CG5771; Drab11; O18335; RAB11; Rab 11; Rab-11; Rab-r11; dRab11; l(3)93Bi; l(3)j2D1; rab-11; rab11; rlr7", "gene_names_refseq": "AAF55850; CG5771; DRAB11; DRab11; Dm Rab11; DmRab11; Dmel\\CG5771; Drab11; O18335; RAB11; Rab 11; Rab-11; Rab-r11; Rab11; dRab11; l(3)93Bi; l(3)j2D1; rab-11; rab11; rlr7", "protein_names_uniprotkb": "Rab11, isoform A; Rab11, isoform B", "protein_names_refseq": "CG5771-PB; Rab-protein 11; Rab11, isoform B; Rab11-PB; lethal(3)93Bi", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (dme:Dmel_CG5771); (R-DME-432040); (R-DME-5620916); (R-DME-8873719)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0048749 compound eye development;GO:1990182 exosomal secretion;GO:0006897 endocytosis;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O18335-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O18413-1", "uniprot_id": "PRS8_DROME", "mass": 45857.0, "length": 405, "protein_name": "26S proteasome regulatory subunit 8", "gene_name": "Rpt6", "organism": "Fruit fly", "refseq_name": "regulatory particle triple-A ATPase 6", "refseq_ac": "NP_608447", "gene_names_uniprotkb": "Rpt6; CG1489; DUG; Pros45; Ug", "gene_names_refseq": "1489; CG1489; DUG; Dm_Rpt6a; Dmel\\CG1489; Dug; PRS8_DROME; Pros45; Rpt6; S8; Ug; dRpt6; p42C; pros45; sug-1; sug1", "protein_names_uniprotkb": "26S proteasome regulatory subunit 8", "protein_names_refseq": "26S proteasome regulatory subunit 8; CG1489-PA; Pros45; Rpt6-PA; p42C; proteasomal subunit 8; regulatory particle triple-A ATPase 6", "tax_id": 7227, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); Alzheimer's disease (Disease Ontology:DOID:10652); cancer (Disease Ontology:DOID:162); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); myopathy (Disease Ontology:DOID:423)", "pathway": " (dme:Dmel_CG1489); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 56, "publication_count": 39, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537569;12537572;12973300;15178801;15258584;15331761;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17925225;18519643;18593878;19185492;22187461;25027767;7705656;8948598;9025065;9215627;9469929;9553105;9738875;9990853", "class_list": "", "function": "The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O45023", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "O18413-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46043-1", "uniprot_id": "PARG_DROME", "mass": 81109.0, "length": 723, "protein_name": "Poly(ADP-ribose) glycohydrolase", "gene_name": "Parg", "organism": "Fruit fly", "refseq_name": "Poly(ADP-ribose) glycohydrolase, isoform B", "refseq_ac": "NP_001245511", "gene_names_uniprotkb": "Parg; CG2864", "gene_names_refseq": "CG2864; Dmel\\CG2864; EG:114E2.1; HD10914; PARG; Parg; dParg; parg", "protein_names_uniprotkb": "Poly(ADP-ribose) glycohydrolase; 3.2.1.143; 3.2.2.-; [Protein ADP-ribosylserine] hydrolase", "protein_names_refseq": "CG2864-PB; Parg-PB; Poly(ADP-ribose) glycohydrolase, isoform B; Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose)glycohydrolase; Poly(ADPribose) glyco-hydrolase", "tax_id": 7227, "disease": "stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (Disease Ontology:DOID:0070352); brain infarction (Disease Ontology:DOID:3454); borna disease (Disease Ontology:DOID:5154)", "pathway": " (dme:Dmel_CG2864)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10731137;12537569;12537572;14676324;16219773;17827147;18327897;19229318;22178397;22242017;30100084;34949666;37268618", "class_list": "", "function": "Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose) (PubMed:16219773, PubMed:22178397, PubMed:37268618). Mainly acts as an exo-glycohydrolase but can act as an endo-glycohydrolase at low efficiency (By similarity). Also has protein ADP-ribosylserine hydrolase activity and is able to remove the terminal monomeric ADP-ribose from modified serine residues but not from glutamate residues (PubMed:37268618). Polymeric ADP-ribose synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:14676324). De-ADP-ribosylates Parp1 to modulate its subnuclear localization; ADP-ribosylated Parp1 dissociates from chromatin and accumulates in nuclear bodies while de-ADP-ribosylation prevents nuclear body accumulation and promotes association with chromatin (PubMed:16219773, PubMed:19229318). Required for Parp1-mediated repression of retrotransposon amplification by promoting Parp1 localization to chromatin (PubMed:16219773). Together with Parp1 involved in maintaining nucleolar integrity (PubMed:16219773). Involved in regulation of histone deacetylation, possibly by regulating the localization of the NAD-dependent protein deacetylase Sirt2 (PubMed:16219773). Polymeric ADP-ribose metabolism is required for maintenance of the normal function of neuronal cells (PubMed:14676324). Important for development and longevity (PubMed:34949666)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9NEU9;Q960N8", "ec_number_list": "3.2.1.143;3.2.2.-", "go_molecular_function": "GO:0004649 poly(ADP-ribose) glycohydrolase activity;GO:0140292 ADP-ribosylserine hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0090734 site of DNA damage", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006974 DNA damage response;GO:0043484 regulation of RNA splicing;GO:0009408 response to heat;GO:0051457 maintenance of protein location in nucleus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O46043-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46072-1", "uniprot_id": "KZ_DROME", "mass": 134121.0, "length": 1192, "protein_name": "Probable ATP-dependent RNA helicase kurz", "gene_name": "kz", "organism": "Fruit fly", "refseq_name": "kurz, isoform B", "refseq_ac": "NP_001284815", "gene_names_uniprotkb": "kz; CG3228; Dmel\\CG3228; Dmel_CG3228; EG:30B8.2; N1; N8; l(1)2Eb; l(1)N4; l67", "gene_names_refseq": "CG3228; Dmel\\CG3228; EG:30B8.2; N1; N8; kz; l(1)2Eb; l(1)N4; l67", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase kurz; 3.6.4.13", "protein_names_refseq": "CG3228-PB; kurz, isoform B; kz-PB", "tax_id": 7227, "disease": "microcephaly (Disease Ontology:DOID:10907); 46,XY complete gonadal dysgenesis (Disease Ontology:DOID:14448)", "pathway": " (dme:Dmel_CG3228); (R-DME-6791226)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537572;12537573;12537574;1579473;16110336;16453754;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.1.13.-;3.-.-.-;5.6.1.1;2.7.11.1;2.1.1.-;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O46072-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46106-1", "uniprot_id": "NOI_DROME", "mass": 58422.0, "length": 503, "protein_name": "Splicing factor 3A subunit 3", "gene_name": "noi", "organism": "Fruit fly", "refseq_name": "noisette", "refseq_ac": "NP_477114", "gene_names_uniprotkb": "noi; CG2925", "gene_names_refseq": "CG2925; Dmel\\CG2925; Noi; SF3A3; SF3a[60]; U2; l(3)j3E7; ms3225; noi", "protein_names_uniprotkb": "Splicing factor 3A subunit 3; Protein noisette", "protein_names_refseq": "CG2925-PA; noi-PA; noisette", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2925); (R-DME-72163); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;9528755", "class_list": "", "function": "Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Involved in male fertility., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0009566 fertilization;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O46106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46199-1", "uniprot_id": "A53E_DROME", "mass": 13607.0, "length": 120, "protein_name": "Accessory gland protein Acp53Ea", "gene_name": "Acp53Ea", "organism": "Fruit fly", "refseq_name": "accessory gland protein 53Ea", "refseq_ac": "NP_477151", "gene_names_uniprotkb": "Acp53Ea; CG8622", "gene_names_refseq": "ACP53EA; Acp53Ea; Acp53E; BcDNA:AT09943; CG8622; Dmel\\CG8622", "protein_names_uniprotkb": "Accessory gland protein Acp53Ea", "protein_names_refseq": "Acp53Ea-PA; CG8622-PA; accessory gland protein 53Ea; accessory gland-specific peptide 53Ea", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8622)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;11102381;12537569;12537572;14761057;15215320;9474779", "class_list": "", "function": "Responsible for physiological and behavioral changes in mated female flies., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GUV6;Q6VBF9;Q6VBG0;Q6VBG1;Q8MZD8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0007618 mating;GO:0046692 sperm competition", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O46199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46201-1", "uniprot_id": "A98AB_DROME", "mass": 2622.0, "length": 25, "protein_name": "Accessory gland protein 98AB", "gene_name": "Acp98AB", "organism": "Fruit fly", "refseq_name": "accessory gland protein 98AB", "refseq_ac": "NP_001263026", "gene_names_uniprotkb": "Acp98AB; CG43619", "gene_names_refseq": "Acp98AB; Acp98Ab; Acp98B; Acp98; CG31056; CG43619; Dmel\\CG43619; acp98AB", "protein_names_uniprotkb": "Accessory gland protein 98AB", "protein_names_refseq": "Acp98AB-PB; CG43619-PB; accessory gland protein 98AB; accessory gland-specific peptide 98AB; accessory gland-specific peptide 98B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43619)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11102381;12537572;9474779", "class_list": "", "function": "Responsible for physiological and behavioral changes in mated female flies., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KHZ7;O46226", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007618 mating;GO:0045434 negative regulation of female receptivity, post-mating", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O46201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46202-1", "uniprot_id": "A62F_DROME", "mass": 12570.0, "length": 115, "protein_name": "Accessory gland protein Acp62F", "gene_name": "Acp62F", "organism": "Fruit fly", "refseq_name": "accessory gland protein 62F", "refseq_ac": "NP_523892", "gene_names_uniprotkb": "Acp62F; CG1262", "gene_names_refseq": "Acp62F; Acp62f; Acp62; CG1262; CT2528; Dmel\\CG1262", "protein_names_uniprotkb": "Accessory gland protein Acp62F", "protein_names_refseq": "Acp62F-PA; CG1262-PA; accessory gland peptide 62F; accessory gland protein 62F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1262)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10612039;10731132;11102381;12537572;14761057;9474779", "class_list": "", "function": "Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0045861 negative regulation of proteolysis;GO:0007618 mating;GO:0046692 sperm competition", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O46202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46227-1", "uniprot_id": "A33A_DROME", "mass": 5282.0, "length": 47, "protein_name": "Accessory gland peptide Acp33A", "gene_name": "Acp33A", "organism": "Fruit fly", "refseq_name": "accessory gland-specific peptide 33A", "refseq_ac": "NP_523550", "gene_names_uniprotkb": "Acp33A; CG6555", "gene_names_refseq": "Acp33A; Acp33a; CG15841; CG32952-A; CG32952; CG6555; Dmel\\CG6555", "protein_names_uniprotkb": "Accessory gland peptide Acp33A", "protein_names_refseq": "Acp33A-PA; CG6555-PA; accessory gland protein 33A; accessory gland-specific peptide 33A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6555)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11102381;12537572;9474779", "class_list": "", "function": "Responsible for physiological and behavioral changes in mated female flies., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0007618 mating;GO:0045434 negative regulation of female receptivity, post-mating", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O46227-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O46339-1", "uniprot_id": "HTH_DROME", "mass": 52784.0, "length": 487, "protein_name": "Homeobox protein homothorax", "gene_name": "hth", "organism": "Fruit fly", "refseq_name": "homothorax, isoform E", "refseq_ac": "NP_001014613", "gene_names_uniprotkb": "hth; CG17117; dtl", "gene_names_refseq": "1323/07; 1422/04; CG17117; Dm-HTH; Dmel\\CG17117; HTH; Hth; MEIS1; Meis1; P53; anon-EST:Liang-2.13; clone 2.13; dtl; hth1; hth2; hth; l(3)05745; l(3)86Ca", "protein_names_uniprotkb": "Homeobox protein homothorax; Homeobox protein dorsotonals", "protein_names_refseq": "CG17117-PE; dorsotonals; gene II; homothorax, isoform E; homothorax; hth-PE", "tax_id": 7227, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); orofacial cleft (Disease Ontology:DOID:0050567); cleft palate, cardiac defects, and intellectual disability (Disease Ontology:DOID:0111697); open-angle glaucoma (Disease Ontology:DOID:1067); heart disease (Disease Ontology:DOID:114); leukemia (Disease Ontology:DOID:1240); brain infarction (Disease Ontology:DOID:3454); cleft palate (Disease Ontology:DOID:674); learning disability (Disease Ontology:DOID:8927)", "pathway": " (dme:Dmel_CG17117); (R-DME-390193)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537572;14636555;16778079;17889654;18256197;18258485;18258486;18313299;19762509;9346235;9450936;9463350", "class_list": "", "function": "All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt the polarization-sensitive 'dorsal rim area' (DRA) of the eye fate instead of the color-sensitive default state. This occurs by increasing rhabdomere size and uncoupling R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O17427;Q058V1;Q4AB34;Q59DX7;Q6NR42;Q7KQ21;Q8INL5;Q8INL6;Q9VGY9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060323 head morphogenesis;GO:0007525 somatic muscle development;GO:0010092 specification of animal organ identity;GO:0048749 compound eye development;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O46339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O61491-1", "uniprot_id": "FLOT1_DROME", "mass": 47135.0, "length": 426, "protein_name": "Flotillin-1", "gene_name": "Flo1", "organism": "Fruit fly", "refseq_name": "flotillin 1, isoform A", "refseq_ac": "NP_477358", "gene_names_uniprotkb": "Flo1; CG8200; FLODM-1; Flo-1; Flo", "gene_names_refseq": "CG8200; CK02126; Dmel\\CG8200; FLO1; FLO[Dm]-1; FLO[Dm]; Flo-1; Flo1; Flo[Dm]; Flot1; Flo; dFlot1; flo1; flotillin; flo; reggie-2", "protein_names_uniprotkb": "Flotillin-1", "protein_names_refseq": "CG8200-PA; Flo1-PA; Flotillin-1; Flotillin1; flotillin 1, isoform A; flotillin; reggie2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8200); (R-DME-8849932); (R-DME-8980692)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9573373", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V7D7", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0016600 flotillin complex", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0002090 regulation of receptor internalization;GO:0045807 positive regulation of endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O61491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O61722-1", "uniprot_id": "PRL1_DROME", "mass": 19973.0, "length": 176, "protein_name": "PRL-1 phosphatase", "gene_name": "PRL-1", "organism": "Fruit fly", "refseq_name": "PRL-1 phosphatase, isoform C", "refseq_ac": "NP_001260487", "gene_names_uniprotkb": "PRL-1; BG:DS07473.3; CG4993; PRL", "gene_names_refseq": "BG:DS07473.3; BcDNA:RE40268; CG4993; Dmel\\CG4993; PRL-1; PRL1; PRL; PrL-1; Prl-1; dPRL-1; prl-1; prl1", "protein_names_uniprotkb": "PRL-1 phosphatase; 3.1.3.48; Phosphatase of regenerating liver-1", "protein_names_refseq": "CG4993-PC; PRL-1 phosphatase, isoform C; PRL-1-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4993); (R-DME-8873719)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;23577193;31048465;31404830", "class_list": "", "function": "Probable phosphatase (Probable). Inhibits growth possibly by negatively regulating Src64B-induced growth (PubMed:23577193). Regulates central nervous system circuit formation and stabilization of synapse-dense terminal arbors (PubMed:31048465). In dorsocentral neurons, regulates synaptogenesis in terminal arbors via modulation of the insulin receptor pathway, likely upstream of Akt1, and via reduction of PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) levels (PubMed:31048465). In the nervous system, plays a protective role together with uex in response to olfactory carbon dioxide stimulation (PubMed:31404830)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95VY8", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.-;3.1.3.2;3.1.3.27;2.5.1.60", "go_molecular_function": "GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0016327 apicolateral plasma membrane", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0071244 cellular response to carbon dioxide", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O61722-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O61735-1", "uniprot_id": "CLOCK_DROME", "mass": 116142.0, "length": 1027, "protein_name": "Circadian locomoter output cycles protein kaput", "gene_name": "Clk", "organism": "Fruit fly", "refseq_name": "clock, isoform F", "refseq_ac": "NP_001014574", "gene_names_uniprotkb": "Clk; CG7391; CLOCK; PAS1; jrk", "gene_names_refseq": "CG7391; CLK; CLOCK; Clk; Dmel\\CG7391; Jerk; Jrk; PAS1; bHLHe10; clk; clock; dCLK/JRK; dCLK; dCLOCK; dClck; dClk; dClock; dclk; jrk", "protein_names_uniprotkb": "Circadian locomoter output cycles protein kaput; dCLOCK; dPAS1", "protein_names_refseq": "CG7391-PF; CLOCK; Clk-PF; clock, isoform F; dClock", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); cholestasis (Disease Ontology:DOID:13580); alcohol use disorder (Disease Ontology:DOID:1574); bipolar disorder (Disease Ontology:DOID:3312); sleep disorder (Disease Ontology:DOID:535); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dme:Dmel_CG7391); (R-DME-432395); (R-DME-432408); (R-DME-432501); (R-DME-432524); (R-DME-432560); (R-DME-432620); (R-DME-432626)", "pathway_count": 8, "publication_count": 41, "publication_id_list": "10409723;10417378;10481010;10612401;10684876;10731132;11430804;11585911;12432393;12442174;12537572;12546820;12581523;14980226;15178801;15186484;15258584;16139204;16410523;16543224;16603629;16794082;17452449;17555964;17575052;17578907;17578908;18375860;18474612;18593878;19139270;19185492;19726650;20159956;25121504;8596938;8600384;9616122;9630223;9742131;9808471", "class_list": "", "function": "Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to PubMed:9742131, reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas PubMed:9616122 describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced, Period and Timeless block Clock's ability to transactivate their promoters., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1L9;A4V1M0;O76342;O77137;Q59E25;Q9VSB0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "O61735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O62531-1", "uniprot_id": "O62531_DROME", "mass": 48940.0, "length": 426, "protein_name": "Adaptor protein complex 1, mu subunit", "gene_name": "AP-1mu", "organism": "Fruit fly", "refseq_name": "adaptor protein complex 1, mu subunit", "refseq_ac": "NP_649906", "gene_names_uniprotkb": "AP-1mu; AP-1 M; AP-1mu1; AP-47; AP1mu1; AP1mu; AP47; APmu1; CG9388; Dmel\\CG9388; Dmel_CG9388; Dmu1; ap-1u; ap-47; apm1; cg9388; mu1", "gene_names_refseq": "AP-1 M; AP-1mu1; AP-1mu; AP-47; AP1mu1; AP1mu; AP47; APmu1; CG9388; Dmel\\CG9388; Dmu1; ap-1u; ap-47; apm1; cg9388; mu1", "protein_names_uniprotkb": "Adaptor protein complex 1, mu subunit", "protein_names_refseq": "AP-1mu-PA; AP-47; CG9388-PA; adaptor protein complex 1, mu subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9388); (R-DME-432720); (R-DME-432722); (R-DME-6798695)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030276 clathrin binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0033363 secretory granule organization;GO:2001136 negative regulation of endocytic recycling;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O62531-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O76454-1", "uniprot_id": "PHS_DROME", "mass": 21067.0, "length": 192, "protein_name": "Pterin-4-alpha-carbinolamine dehydratase", "gene_name": "Pcd", "organism": "Fruit fly", "refseq_name": "pterin-4a-carbinolamine dehydratase", "refseq_ac": "NP_477360", "gene_names_uniprotkb": "Pcd; CG1963", "gene_names_refseq": "BcDNA:LP07248; CG1963; Dmel\\CG1963; PCD; Pcd; pCD", "protein_names_uniprotkb": "Pterin-4-alpha-carbinolamine dehydratase; 4-alpha-hydroxy-tetrahydropterin dehydratase; 4.2.1.96; PCD; PHS; Pterin carbinolamine dehydratase", "protein_names_refseq": "CG1963-PA; Pcd-PA; pterin-4a-carbinolamine dehydratase", "tax_id": 7227, "disease": "BH4-deficient hyperphenylalaninemia D (Disease Ontology:DOID:0081131)", "pathway": " (dme:Dmel_CG1963); (R-DME-8964208)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9774744", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C6SV03", "ec_number_list": "4.2.1.96", "go_molecular_function": "GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006729 tetrahydrobiopterin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O76454-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O76460-1", "uniprot_id": "RAD54_DROME", "mass": 89534.0, "length": 784, "protein_name": "DNA repair and recombination protein RAD54-like", "gene_name": "okr", "organism": "Fruit fly", "refseq_name": "okra", "refseq_ac": "NP_476661", "gene_names_uniprotkb": "okr; CG3736; RAD54", "gene_names_refseq": "CG3736; DhR54; DmRAD54; DmRad54; Dmel\\CG3736; Dmrad54; OKR; Okr; RAD54L; RAD54; Rad54; Ras54; okr; rad54", "protein_names_uniprotkb": "DNA repair and recombination protein RAD54-like; 3.6.4.-; DmRAD54; Protein okra; RAD54 DNA repair protein", "protein_names_refseq": "CG3736-PA; okr-PA; okra", "tax_id": 7227, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); sclerocornea (Disease Ontology:DOID:0060252); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dme:Dmel_CG3736)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537572;15105430;17660539;18327897;18984573;9315669;9732269", "class_list": "", "function": "Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6UXG7;B6UXH8;B6UXJ2;B6UXJ5;P91636;Q7K0T1;Q7KPH9", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015616 DNA translocase activity;GO:0140658 ATP-dependent chromatin remodeler activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006417 regulation of translation;GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O76460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O76922-1", "uniprot_id": "AUB_DROME", "mass": 98559.0, "length": 866, "protein_name": "Protein aubergine", "gene_name": "aub", "organism": "Fruit fly", "refseq_name": "aubergine, isoform C", "refseq_ac": "NP_001097144", "gene_names_uniprotkb": "aub; CG6137; sti", "gene_names_refseq": "AUBERGINE; AUB; Aub; CG6137; Dmel\\CG6137; aub; ms(2)32D; sting; sti", "protein_names_uniprotkb": "Protein aubergine; 3.1.26.-; Protein sting", "protein_names_refseq": "Aub; CG6137-PC; aub-PC; aubergine, isoform C; aubergine; stellate-interacting gene", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6137)", "pathway_count": 1, "publication_count": 38, "publication_id_list": "10731132;11526087;12154120;12537569;12537572;12538514;14752161;15035984;15090597;15372228;16452506;17322028;17346786;17428915;1783295;17872506;18590813;19377467;19395009;19926723;19959991;20713507;20937269;20953170;20980675;21447556;21831924;22303351;22997235;23267055;23559253;26212455;26295961;28945271;34210982;8625849;8676882;9927466", "class_list": "", "function": "Component of the perinuclear meiotic nuage, a germline-specific subcellular membraneless ribonucleoprotein compartment involved in production of transposable element-repressing Piwi-interacting RNA (piRNA)-induced silencing complexes (piRISCs), which are essential for maintaining germline integrity during oogenesis; essential for the formation and/or structural integrity of nuage particles (PubMed:12538514, PubMed:15090597, PubMed:17428915, PubMed:18590813, PubMed:26212455, PubMed:26295961). Acts via the Piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:17346786, PubMed:19959991, PubMed:20980675, PubMed:34210982). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:17872506, PubMed:19959991, PubMed:20980675, PubMed:26212455, PubMed:26295961). Shows RNA cleavage or slicer activity; including aub-piRNA complexes from ovary and testis (PubMed:17322028, PubMed:17872506, PubMed:34210982). When loaded with guide piRNAs recognizes and cleaves complementary RNAs to repress their expression and produce complementary piRNAs (PubMed:17346786, PubMed:34210982). Together with Piwi protein AGO3 recruited to subregions of the perinuclear nuage by krimp, which coordinates their activity in the ping-pong amplification step of secondary piRNA biogenesis (PubMed:26295961, PubMed:34210982). Krimp recruits piRNA bound aub and unbound AGO3, bringing them into close proximity to facilitate the loading onto AGO3 of freshly cut piRNAs generated by aub cleavage of target sequences; krimp recognizes the piRNA loading state of the Piwi proteins via symmetrically dimethylated arginine modification in their N-terminus (PubMed:34210982). Important for asymmetric ping-pong amplification to bias production towards antisense piRNAs capable of silencing transposable elements (PubMed:26212455). Required for the localization of mael and krimp to the meiotic nuage (PubMed:12538514, PubMed:17428915). In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end (PubMed:26212455). In testis, associates with Su(Ste) antisense piRNAs (most abundant class of piRNAs found in complex with aub in testes) and negatively regulates Ste expression, most likely by cleaving its transcripts (PubMed:17872506). Also in testis, may repress translation of vas when associated with a piRNA derived from chromosome X, termed AT-chX-1, whose sequence shows strong complementarity to vas mRNA (PubMed:17872506). Involved in repression of long interspersed nuclear elements (LINEs) including HeT-A, I-element and TART LINEs (PubMed:17428915). Repression of specialized telomeric retroelements HeT-A and TART is involved in telomere regulation; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements (PubMed:16452506). Also involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans, in the female germline, a homologous transposon, or transgene located in euchromatin (PubMed:14752161, PubMed:15372228). Involved in the suppression of meiotic drive of sex chromosomes and autosomes (PubMed:23267055, PubMed:9927466). Involved in transposon silencing in the adult brain (PubMed:23559253). Required for dorsal-ventral as well as anterior-posterior patterning of the egg (PubMed:11526087). Required during oogenesis for primordial germ cell formation and activation of RNA interference (PubMed:12154120). During early oogenesis, required for osk mRNA silencing and polarization of the microtubule cytoskeleton (PubMed:15035984, PubMed:1783295, PubMed:8625849). During mid-oogenesis, required for osk mRNA localization to the posterior pole and efficient translation of osk and grk (PubMed:15035984, PubMed:1783295, PubMed:8625849). During embryogenesis, required for posterior localization of nanos (nos) mRNA, independently of osk, and pole cell formation (PubMed:15035984, PubMed:20937269). Forms a complex with smg, twin, AGO3 and specific piRNAs that targets nanos mRNA (and probably other maternal mRNAS) for deadenylation promoting its decay during early embryogenesis (PubMed:20953170)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8DYZ0;K7WQ34;K7X543;K7XHY9;L0CPY1;L0CQ70;L0CRA0;L0CRA6;L0CRP1;L0CRZ4;L0CS00", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0004521 RNA endonuclease activity;GO:0034584 piRNA binding;GO:0016891 RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0043186 P granule", "go_biological_process": "GO:0007283 spermatogenesis;GO:0050829 defense response to Gram-negative bacterium;GO:0035282 segmentation;GO:0007076 mitotic chromosome condensation;GO:0001556 oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "O76922-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O76924-1", "uniprot_id": "ARI2_DROME", "mass": 58627.0, "length": 509, "protein_name": "Potential E3 ubiquitin-protein ligase ariadne-2", "gene_name": "ari-2", "organism": "Fruit fly", "refseq_name": "ariadne 2", "refseq_ac": "NP_477374", "gene_names_uniprotkb": "ari-2; CG5709; TRIAD1; ari2", "gene_names_refseq": "AAF46823.1; Ari-2; CG5709; Dmel\\CG5709; ari-2; ari2; l(2)07768", "protein_names_uniprotkb": "Potential E3 ubiquitin-protein ligase ariadne-2; 2.3.2.31; Protein ariadne-2; RING-type E3 ubiquitin transferase ariadne-2", "protein_names_refseq": "CG5709-PA; ari-2-PA; ariadne 2; ariadne-2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5709); (R-DME-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;10880484;12537572;29689197", "class_list": "", "function": "Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;2.3.2.25;2.3.2.23;2.3.2.31;2.3.2.26;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O76924-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O77264-1", "uniprot_id": "RTCA_DROME", "mass": 39503.0, "length": 361, "protein_name": "RNA 3'-terminal phosphate cyclase", "gene_name": "Rtca", "organism": "Fruit fly", "refseq_name": "RNA 3'-terminal phosphate cyclase, isoform B", "refseq_ac": "NP_001284801", "gene_names_uniprotkb": "Rtca; CG4061; Dmel\\CG4061; Dmel_CG4061; EG:22E5.3; RTC1_DROME", "gene_names_refseq": "CG4061; Dmel\\CG4061; EG:22E5.3; RTC1_DROME; Rtca", "protein_names_uniprotkb": "RNA 3'-terminal phosphate cyclase; 6.5.1.4; RNA cyclase; RNA-3'-phosphate cyclase", "protein_names_refseq": "CG4061-PB; RNA 3'-terminal phosphate cyclase, isoform B; Rtca-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4061)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;25961792;26109356;26109357;31919191", "class_list": "", "function": "Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (By similarity). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (By similarity). Likely functions in some aspects of cellular RNA processing (By similarity). Function plays an important role in a RNA repair and splicing pathway which controls axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury (PubMed:25961792, PubMed:31919191). In response to axotomy, negatively regulates splicing of Xbp1 which in turn activates downstream effectors which inhibit axon regeneration, including down-regulating the microtubule regulators ringer and futsch (PubMed:25961792, PubMed:31919191)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.5.1.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0003963 RNA-3'-phosphate cyclase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:0048681 negative regulation of axon regeneration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O77264-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O77286-1", "uniprot_id": "U239_DROME", "mass": 9630.0, "length": 87, "protein_name": "Protein anon-73B1", "gene_name": "anon-73B1", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_648908", "gene_names_uniprotkb": "anon-73B1; CG4101; anon73B1", "gene_names_refseq": "CG4101; Dmel\\CG4101; anon-73B1; anon73B1", "protein_names_uniprotkb": "Protein anon-73B1", "protein_names_refseq": "CG4101-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4101)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11361347;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3Y1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O77286-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O96651-1", "uniprot_id": "TOP3B_DROME", "mass": 96973.0, "length": 875, "protein_name": "DNA topoisomerase 3-beta", "gene_name": "Top3beta", "organism": "Fruit fly", "refseq_name": "topoisomerase 3beta, isoform B", "refseq_ac": "NP_001284938", "gene_names_uniprotkb": "Top3beta; CG3458; Dmel\\CG3458; Dmel_CG3458; TOP3; Top3; Topo IIIbeta; dTop3beta; top3[beta]; top3beta; top3; topo III[beta]", "gene_names_refseq": "CG3458; Dmel\\CG3458; TOP3; Top3beta; Top3; Topo IIIbeta; dTop3beta; top3[beta]; top3beta; top3; topo III[beta]", "protein_names_uniprotkb": "DNA topoisomerase 3-beta; 5.6.2.1; DNA topoisomerase III beta", "protein_names_refseq": "CG3458-PB; Top 3beta; Top3beta-PB; drosophila topoisomerase 3beta; topoisomerase 3beta, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3458)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10636841;10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand., [UniProtKB, UniProtKB]; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5U0X6;Q9W416", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity;GO:0140226 RNA topoisomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0140225 DNA topoisomerase III-beta-TDRD3 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0045727 positive regulation of translation;GO:0006265 DNA topological change;GO:0141194 siRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O96651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48987-1", "uniprot_id": "ATO_DROME", "mass": 34116.0, "length": 312, "protein_name": "Protein atonal", "gene_name": "ato", "organism": "Fruit fly", "refseq_name": "atonal", "refseq_ac": "NP_731223", "gene_names_uniprotkb": "ato; CG7508", "gene_names_refseq": "ATO; Ato; At; CG7508; Dmel\\CG7508; ato1; ato[Dm]; ato; bHLHa10", "protein_names_uniprotkb": "Protein atonal", "protein_names_refseq": "CG7508-PA; ato-PA; atonal; atona", "tax_id": 7227, "disease": "persistent hyperplastic primary vitreous (Disease Ontology:DOID:0060282)", "pathway": " (dme:Dmel_CG7508)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;16951084;8196767;8324823", "class_list": "", "function": "Developmental protein involved in neurogenesis. Required for the formation of chordotonal organs and photoreceptors. Seems to bind to E boxes. Specifically required for the photoreceptor R8 selection., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AQ36;A0AQ37;A0AQ43;Q9VHU0", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010608 post-transcriptional regulation of gene expression;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48987-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q26366-1", "uniprot_id": "VG_DROME", "mass": 46327.0, "length": 453, "protein_name": "Protein vestigial", "gene_name": "vg", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "vg; CG3830", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein vestigial", "protein_names_refseq": "", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3830)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;11546746;12537572;14526388;1752439;9230443;9869635;9869643", "class_list": "", "function": "Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr, may control genes involved in DNA replication., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V6H9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007525 somatic muscle development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q26366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23647-1", "uniprot_id": "FUSED_DROME", "mass": 90347.0, "length": 805, "protein_name": "Serine/threonine-protein kinase fused", "gene_name": "fu", "organism": "Fruit fly", "refseq_name": "fused", "refseq_ac": "NP_477499", "gene_names_uniprotkb": "fu; CG6551", "gene_names_refseq": "CG6551; Dm fu; Dmel\\CG6551; FU; Fu; d Fu; dFu; fu[mel]; fu; l(1)fu", "protein_names_uniprotkb": "Serine/threonine-protein kinase fused; 2.7.11.1", "protein_names_refseq": "CG6551-PA; fu-PA; fused", "tax_id": 7227, "disease": "hydrocephalus (Disease Ontology:DOID:10908); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dme:Dmel_CG6551); (R-DME-209159); (R-DME-209190); (R-DME-209214); (R-DME-209338); (R-DME-209360); (R-DME-216119); (R-DME-216217)", "pathway_count": 8, "publication_count": 61, "publication_id_list": "10102270;10409506;10458606;10477300;10529426;10557210;10731132;10825151;10862738;10862750;10952898;10966113;11090136;11495917;11912487;11914126;11934882;11955435;11997517;12231619;12537572;12663920;14523402;14597665;14614827;14636583;15063184;15300262;15563523;15592457;15598741;15616566;15691767;15750186;15875013;16041759;16299518;16326393;16386907;16630821;17077139;17182028;17671093;17881487;17925225;17960137;18211840;18327897;2168522;8155575;8307322;8769644;8898207;8906787;8906794;9109493;9122207;9215627;9431812;9482888;9601642", "class_list": "", "function": "Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q26346;Q26347;Q27412;Q9VWR7", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;5.6.1.8;2.7.11.11;2.7.11.23;3.1.3.16;2.3.2.23;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;3.4.19.-;5.6.1.5;3.4.19.12;2.7.11.39", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0005119 smoothened binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0032991 protein-containing complex;GO:0035301 Hedgehog signaling complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030514 negative regulation of BMP signaling pathway;GO:0031398 positive regulation of protein ubiquitination;GO:0007224 smoothened signaling pathway;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "P23647-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21187-1", "uniprot_id": "PABP_DROME", "mass": 69925.0, "length": 634, "protein_name": "Polyadenylate-binding protein", "gene_name": "pAbp", "organism": "Fruit fly", "refseq_name": "poly(A) binding protein, isoform A", "refseq_ac": "NP_476667", "gene_names_uniprotkb": "pAbp; CG5119", "gene_names_refseq": "BABP; BcDNA:LD24412; CG16803; CG5119; Dmel\\CG5119; PABP55B; PABPC1; PABP; PAbp; Pabp; anon-EST:Posey247; anon-EST:Posey249; anon-EST:fe2E5; dPABP; duo; l(2)SH1908; l(2)SH2 1908; l(2)k10109; pABP; pABp; pAB; pAbp; pabp", "protein_names_uniprotkb": "Polyadenylate-binding protein; PABP; Poly(A)-binding protein", "protein_names_refseq": "CG5119-PA; Poly(A) binding protein; Poly(A)-binding protein; Poly(A)binding protein; PolyA-binding protein; Polyadenylate-binding protein; anon-fast-evolving-2E5; cytoplasmic poly-A binding protein; doppio fuso; lethal (2) SH1908; pAbp-PA; poly (A)-binding protein; poly(A) binding protein, isoform A; poly-A binding protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5119); (R-DME-156827); (R-DME-429947); (R-DME-450408); (R-DME-72649); (R-DME-975956); (R-DME-975957)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;19631203;19797087;2125288;28190776;28388438;28875934;36688322;8482550", "class_list": "", "function": "Binds the poly(A) tail of mRNA (PubMed:2125288). Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex (PubMed:28388438). Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively (PubMed:28388438). The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors, whereas the repressor complex (Atx2-Not1 repressor complex) promotes Not1-dependent post-transcriptional gene silencing and supports high-amplitude circadian rhythms in a per-independent manner (PubMed:28388438). In 0-1 hour embryos, forms a ribonucleoprotein complex (RNP) with me31B, eIF4E1, tral and cup which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934). Involved in germline stem cell transit amplification, differentiation and mitosis-to-meiosis transition (PubMed:28190776)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZM5;Q0E932;Q9V8C3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007268 chemical synaptic transmission;GO:0045727 positive regulation of translation;GO:0007140 male meiotic nuclear division;GO:0007289 spermatid nucleus differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P21187-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51123-1", "uniprot_id": "TAF1_DROME", "mass": 239315.0, "length": 2129, "protein_name": "Transcription initiation factor TFIID subunit 1", "gene_name": "Taf1", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 1, isoform A", "refseq_ac": "NP_476956", "gene_names_uniprotkb": "Taf1; 230; BG:DS00004.13; CG17603; Dmel\\CG17603; Dmel_CG17603; EfW1; SR3-5; TAF1; TAF200; TAF230; TAF250; TAFII-250; TAFII250; TAF[II]250; TAF[[II]]230; TAF[[II]]250; TAF[[II]]; TAF; TFIID TAF250; TFIID; Taf1p; Taf200; Taf230; Taf250; Taf[[II]]250; cell; cel; d230; dTAF1; dTAF230; dTAF250; dTAFII250; dTAF[[II]]230; dTAF[[II]]250; dmTAF1; dmTAF[[II]]230; l(3)84Ab; p230; taf1", "gene_names_refseq": "BG:DS00004.13; CG17603; Dmel\\CG17603; EfW1; SR3-5; TAF1; TAF200; TAF230; TAF250/230; TAF250; TAFII-250; TAFII250; TAF[II]250; TAF[[II]]230; TAF[[II]]250/230; TAF[[II]]250; TAF[[II]]; TAF; TFIID TAF250; TFIID; Taf1p; Taf1; Taf200; Taf230; Taf250; Taf[[II]]250; cell; cel; d230; dTAF1; dTAF230; dTAF250; dTAFII250; dTAF[[II]]230; dTAF[[II]]250; dmTAF1; dmTAF[[II]]230; l(3)84Ab; p230; taf1", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 1; 2.7.11.1; TAFII-230; TAFII250; TBP-associated factor 230 kDa; Transcription initiation factor TFIID 230 kDa subunit; p230", "protein_names_refseq": "CG17603-PA; TATA-associated factor 250; TBP-associated factor 1, isoform A; TBP-associated factor 250kD; TFIID 230 kda subunit; Taf1-PA; cell lethal; suppressor of Ras85D 3-5", "tax_id": 7227, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); X-linked dystonia-parkinsonism (Disease Ontology:DOID:0090057)", "pathway": " (dme:Dmel_CG17603); (R-DME-674695); (R-DME-6804756); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 7, "publication_count": 21, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15143281;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8178153;8262073;8327460;8464492;8504928;8625415;9741622", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O97068;Q7KSX6;Q7KSX7;Q86LF7;Q9TX96", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;2.7.7.6;5.6.1.8;2.7.11.11;2.7.11.23;2.7.12.1;2.7.11.25;5.6.2.4;2.7.11.12;2.7.12.2;5.6.2.3;2.7.10.2;2.7.11.39", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0043565 sequence-specific DNA binding;GO:0017025 TBP-class protein binding;GO:0004839 ubiquitin activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005669 transcription factor TFIID complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P51123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25822-1", "uniprot_id": "PUM_DROME", "mass": 157528.0, "length": 1533, "protein_name": "Maternal protein pumilio", "gene_name": "pum", "organism": "Fruit fly", "refseq_name": "pumilio, isoform G", "refseq_ac": "NP_001262403", "gene_names_uniprotkb": "pum; CG9755; CG9763; Dmel\\CG9755; Dmel_CG9755; EP(3)0883; PKL; PUM; Pum; anon-WO0172774.19; bem; fs(3)02003; l(3)01688; ova; ovt; pkl", "gene_names_refseq": "CG9755; CG9763; Dmel\\CG9755; EP(3)0883; PKL; PUM; Pum; anon-WO0172774.19; bem; fs(3)02003; l(3)01688; ova; ovt; pkl; pum", "protein_names_uniprotkb": "Maternal protein pumilio", "protein_names_refseq": "CG9755-PG; PUMILIO; bemused; milord; ovarette; pum-PG; pumilio, isoform G; pumillio; pumuckel", "tax_id": 7227, "disease": "cerebellar ataxia type 47 (Disease Ontology:DOID:0111743)", "pathway": " (dme:Dmel_CG9755); (R-DME-432722)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10541556;10731132;11274060;11336677;12537568;12537569;12537572;12537573;12537574;1459455;1576962;16110336;17178403;17569856;17569867;18327897;22345517;25589440;26109356;26109357;9404893;9660969", "class_list": "", "function": "Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:1459455, PubMed:1576962, PubMed:22345517, PubMed:9404893, PubMed:9660969). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of deadenylase complexes leading to translational inhibition and mRNA degradation (By similarity). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:22345517). Mediates post-transcriptional silencing of E2f mRNA by binding to its 3'-UTR and promoting miRNA regulation (PubMed:22345517). Required for abdominal development and to support proliferation and self-renewal of germ cells. Pum is the only gene required for nanos (nos) activity that is not also required for posterior localization of germline determinants. Pum is required during embryogenesis when nanos activity apparently moves anteriorly from the posterior pole (PubMed:1459455, PubMed:1576962, PubMed:9404893, PubMed:9660969)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4V2K5;Q5BIA7;Q7YU65;Q8IGA8;Q9VHH4;Q9VHH6", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:1905762 CCR4-NOT complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0031594 neuromuscular junction;GO:0071598 neuronal ribonucleoprotein granule", "go_biological_process": "GO:1901835 positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0000278 mitotic cell cycle;GO:0016477 cell migration;GO:0007268 chemical synaptic transmission;GO:0010608 post-transcriptional regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P25822-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29617-1", "uniprot_id": "PROS_DROME", "mass": 184980.0, "length": 1703, "protein_name": "Homeobox protein prospero", "gene_name": "pros", "organism": "Fruit fly", "refseq_name": "prospero, isoform M", "refseq_ac": "NP_001247046", "gene_names_uniprotkb": "pros; 01; 02; 07; 09; 10; 13; 16; 18; 2; BcDNA:HL08040; CG17228; DMPROSPER; DROPROSA; Dmel\\CG17228; Dmel_CG17228; PROS-1; PROS-2; PROS; Prospero; Prosp; Pros; Pro; Voila; anon-WO0140519.15; l(3)10419; l(3)j12C8; l(3)j6E2; l(3)rH013; l(3)rI160; l(3)rJ806; l(3)rK137; l(3)rK204; l(3)rL433; l(3)rO534; prosp; pro; voila", "gene_names_refseq": "0244/09; 0320/10; 0441/16; 0451/09; 0563/18; 0585/13; 0664/07; 0671/02; 0763/13; 0989/01; 1135/07; 1135/09; 1167/13; 1316/02; 671/2; BcDNA:HL08040; CG17228; DMPROSPER; DROPROSA; Dmel\\CG17228; PROS-1; PROS-2; PROS; Prospero; Prosp; Pros; Pro; Voila; anon-WO0140519.15; l(3)10419; l(3)j12C8; l(3)j6E2; l(3)rH013; l(3)rI160; l(3)rJ806; l(3)rK137; l(3)rK204; l(3)rL433; l(3)rO534; prosp; pros; pro; voila", "protein_names_uniprotkb": "Homeobox protein prospero", "protein_names_refseq": "CG17228-PM; a la voile et a la vapeur; pros-PM; prospero, isoform M; prospero", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG17228)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10731132;11051550;12429095;12537568;12537569;12537572;12537573;12537574;1540176;15837198;16110336;16564014;1720353;17569856;17569867;18327897;18342578;1842358;20152183;23056424;25589440;26109356;26109357;27510969;7909177;9380747", "class_list": "", "function": "Homeodomain protein that controls neuronal identity (PubMed:1842358). As a transcriptional factor, regulates the expression of ftz, eve and en in a subset of neuroblast progeny and modulates the transcriptional activity of other homeodomain proteins such as Dfd (PubMed:12429095, PubMed:15837198, PubMed:9380747). Required for proper neuronal differentiation, axonal outgrowth and pathfinding of most or all neurons and their precursors in central and peripheral nervous systems (PubMed:11051550, PubMed:1540176, PubMed:16564014, PubMed:1720353, PubMed:18342578, PubMed:1842358, PubMed:20152183, PubMed:23056424, PubMed:27510969). Regulates asymmetric stem cell self-renewal together with brat (PubMed:16564014)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4K660;Q6AWI5;Q95SP0;Q9U6A2;Q9VGP8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0045180 basal cortex;GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0014016 neuroblast differentiation;GO:0008049 male courtship behavior;GO:0007402 ganglion mother cell fate determination;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P29617-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q86S05-1", "uniprot_id": "LIG_DROME", "mass": 139491.0, "length": 1375, "protein_name": "Protein lingerer", "gene_name": "lig", "organism": "Fruit fly", "refseq_name": "lingerer, isoform D", "refseq_ac": "NP_001014503", "gene_names_uniprotkb": "lig; CG8715; Dmel\\CG8715; Dmel_CG8715", "gene_names_refseq": "CG8715; Dmel\\CG8715; lig", "protein_names_uniprotkb": "Protein lingerer", "protein_names_refseq": "CG8715-PD; lig-PD; lingerer, isoform D; lingerer; transcription unit A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8715)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10731132;12524348;12537568;12537569;12537572;12537573;12537574;14668197;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357;28604694;33925313;40245499", "class_list": "", "function": "Acts in the nervous system to mediate the control of copulatory organs during courtship., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A1Z794;Q86S06;Q8SZZ7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0060179 male mating behavior;GO:0010468 regulation of gene expression;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT;GO:0035332 positive regulation of hippo signaling;GO:0007620 copulation", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q86S05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08473-1", "uniprot_id": "SQD_DROME", "mass": 36184.0, "length": 344, "protein_name": "RNA-binding protein squid", "gene_name": "sqd", "organism": "Fruit fly", "refseq_name": "squid, isoform E", "refseq_ac": "NP_001247088", "gene_names_uniprotkb": "sqd; BcDNA:GM03761; CG16901; CG17791; CR33328; Dmel\\CG16901; Dmel_CG16901; HRP40; Hrb87Fb; Hrb87; Hrp40; RRM3; Rbp3; SQD; Sqd; Squid; fs(3)00048; hnRNP 1; hnRNP A; hrp40; l(3)EP3631; l(3)j4B4; l(3)j6E3; l(3)j8E7; rrm3", "gene_names_refseq": "BcDNA:GM03761; CG16901; CG17791; CR33328; Dmel\\CG16901; HRP40; Hrb87Fb; Hrb87; Hrp40; RRM3; Rbp3; SQD; Sqd; Squid; fs(3)00048; hnRNP 1; hnRNP A; hrp40; l(3)EP3631; l(3)j4B4; l(3)j6E3; l(3)j8E7; rrm3; sqd", "protein_names_uniprotkb": "RNA-binding protein squid; HNRNP 40; Heterogeneous nuclear ribonucleoprotein 40", "protein_names_refseq": "CG16901-PE; RNA-binding protein 3; heterogeneous-nuclear-ribonucleoprotein-87Fb; lethal (3) j4B4; sqd-PE; squid, isoform E; squid", "tax_id": 7227, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306); transient cerebral ischemia (Disease Ontology:DOID:224); uremia (Disease Ontology:DOID:4676); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG16901); (R-DME-450408); (R-DME-72163); (R-DME-72203); (R-DME-9770562)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10197986;10731132;12537568;12537569;12537572;12537573;12537574;15056611;16110336;1730754;17372656;17569856;17569867;25589440;26109356;26109357;7684991;8417324", "class_list": "", "function": "Component of ribonucleosomes (PubMed:7684991). Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle (PubMed:7684991). At least one of the isoforms is essential in somatic tissues (PubMed:7684991). Interacts with grk mRNA (via 3' UTR) and involved in its localization to the dorsal anterior region of the oocyte during dorsal-ventral axis determination; may function as a ribonuclear protein complex together with otu and Hrb27C (PubMed:10197986, PubMed:15056611). Required for polytene chromosome dispersal in nurse cells during oogenesis; nuclear isoforms play a greater role in this than cytoplasmic isoforms (PubMed:15056611)., [UniProtKB, PubMed, PubMed, PubMed]; May lack a role in dorsoventral pattern determination during oogenesis (PubMed:10197986). May be important in somatic tissues (PubMed:10197986)., [UniProtKB, PubMed]; Required nonredundantly with isoform A/sqdA for dorsoventral pattern determination during oogenesis (PubMed:10197986). May be important in somatic tissues (PubMed:10197986, PubMed:7684991)., [UniProtKB, PubMed, PubMed]; Required nonredundantly with isoform B/SqdS for dorsoventral pattern determination during oogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q26273;Q3ZAN7;Q8IH71;Q8INH1;Q8MSY1;Q9VFT5;Q9VFT6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0017148 negative regulation of translation;GO:0010468 regulation of gene expression;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q08473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08970-1", "uniprot_id": "SUHW_DROME", "mass": 105780.0, "length": 941, "protein_name": "Zinc finger protein su(Hw)", "gene_name": "su(Hw)", "organism": "Fruit fly", "refseq_name": "suppressor of hairy wing, isoform C", "refseq_ac": "NP_001247098", "gene_names_uniprotkb": "su(Hw); CG8573; Dmel\\CG8573; Dmel_CG8573; SU(HW); SUHW; Su(HW); Su(Hw); Su(hw); Su[Hw]; su(HW); su(hw); suHw", "gene_names_refseq": "CG8573; Dmel\\CG8573; SU(HW); SUHW; Su(HW); Su(Hw); Su(hw); Su[Hw]; su(HW); su(Hw); su(hw); suHw", "protein_names_uniprotkb": "Zinc finger protein su(Hw); Protein suppressor of hairy wing", "protein_names_refseq": "CG8573-PC; su(Hw)-PC; suppressor of Hair-Wing; suppressor of hairy wing, isoform C; suppressor of hairy wing; suppressor of hairy-wing", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8573)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10731132;11106742;11350941;11416154;11779804;12537568;12537569;12537572;12537573;12537574;14996934;15574329;16110336;16209949;17569856;17569867;18327897;2462523;25589440;26109356;26109357;28366641;38769058;7664338;7761470;7916729;8382607;8852842;9017397;9491892", "class_list": "", "function": "Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein binds specifically to a region of the gypsy element located 3' of the 5' long terminal repeat (LTR), and may also mediate interaction with other endogenous insulators at sites distinct from those recognized by Cp190. Cooperates with pita and cliff to recruit Cp190 and regulate insulator function at the front-ultraabdominal (Fub) boundary (PubMed:38769058)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KI74;Q9VFK9", "ec_number_list": "", "go_molecular_function": "GO:0043035 chromatin insulator sequence binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0035075 response to ecdysone;GO:1905632 protein localization to euchromatin", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P08970-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q86B79-1", "uniprot_id": "UNK_DROME", "mass": 68442.0, "length": 599, "protein_name": "RING finger protein unkempt", "gene_name": "unk", "organism": "Fruit fly", "refseq_name": "unkempt, isoform C", "refseq_ac": "NP_001247253", "gene_names_uniprotkb": "unk; CG4620; Dmel\\CG4620; Dmel_CG4620", "gene_names_refseq": "CG4620; Dmel\\CG4620; unk", "protein_names_uniprotkb": "RING finger protein unkempt", "protein_names_refseq": "CG4620-PC; unk-PC; unkempt, isoform C; unkempt", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4620); (R-DME-983168)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1339381;16110336;17372656;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Essential for late larval/early pupal development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V397;Q24580;Q5BIG8;Q960U9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0048749 compound eye development;GO:0030182 neuron differentiation;GO:0050767 regulation of neurogenesis;GO:0002164 larval development;GO:0007476 imaginal disc-derived wing morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q86B79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54623-1", "uniprot_id": "CNN_DROME", "mass": 149521.0, "length": 1320, "protein_name": "Centrosomin", "gene_name": "cnn", "organism": "Fruit fly", "refseq_name": "centrosomin, isoform G", "refseq_ac": "NP_001163141", "gene_names_uniprotkb": "cnn; Arr; CG 4832; CG18370; CG4832; CNN; Cnn1; Cnn; Dmel\\CG4832; Dmel_CG4832; cen; mat(2)syn-C; mat(2)synHK21; mfs; obv", "gene_names_refseq": "CG 4832; CG18370; CG4832; CNN; Cnn1; Cnn; Dmel\\CG4832; cen; cnn; mat(2)syn-C; mat(2)synHK21; mfs; obv", "protein_names_uniprotkb": "Centrosomin; Protein arrow", "protein_names_refseq": "CDK5RAP2; CG4832-PG; centrosmin; centrosomin, isoform G; centrosomin; cnn-PG; maternal effect syncytial blastoderm arrest C; oblivious", "tax_id": 7227, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); primary autosomal recessive microcephaly 3 (Disease Ontology:DOID:0070286); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (dme:Dmel_CG4832)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;32066907;8582295;8653793;9548723", "class_list": "", "function": "Core component of the centrosome throughout spermatogenesis. May participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. Is a target of several homeotic genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4K705;E1JH56;Q5BIF5;Q86NP3;Q8IHE5;Q8ML65;Q9V6P7;Q9V6P8", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0005814 centriole", "go_biological_process": "GO:0030997 regulation of centriole-centriole cohesion;GO:0007417 central nervous system development;GO:0040016 embryonic cleavage;GO:0007494 midgut development;GO:0007422 peripheral nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P54623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JUY7-1", "uniprot_id": "CED6_DROME", "mass": 56140.0, "length": 517, "protein_name": "PTB domain-containing adapter protein ced-6", "gene_name": "ced-6", "organism": "Fruit fly", "refseq_name": "ced-6, isoform C", "refseq_ac": "NP_610488", "gene_names_uniprotkb": "ced-6; CED-6; CG11804; Ced-6; Dmel\\CG11804; Dmel_CG11804; ced6; dCED-6; dCed-6; dced-6; dced6; drCed-6; drCed6; drced-6", "gene_names_refseq": "CED-6; CG11804; Ced-6; Dmel\\CG11804; ced-6; ced6; dCED-6; dCed-6; dced-6; dced6; drCed-6; drCed6; drced-6", "protein_names_uniprotkb": "PTB domain-containing adapter protein ced-6; Cell death protein 6 homolog", "protein_names_refseq": "CG11804-PC; ced-6, isoform C; ced-6-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11804)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10574763;10731132;12537568;12537569;12537572;12537573;12537574;16110336;16772168;17372656;17569856;17569867;18327897;19707574;19890048;19927123;25589440;26109356;26109357", "class_list": "", "function": "Plays a role in axon pruning in larval mushroom body neurons during metamorphosis (PubMed:16772168). Plays a role in the infiltration of glial cell processes into mushroom body lobes and the subsequent engulfment of degenerating axon branches (PubMed:16772168). Involved in Drpr-mediated phagocytosis of apoptotic cells (PubMed:19927123). Required for bacterial phagocytosis (PubMed:19890048). During neuromuscular junction development, required for the clearance of pruned ghost boutons and presynaptic debris and for normal synaptic growth (PubMed:19707574)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016322 neuron remodeling;GO:0043277 apoptotic cell clearance;GO:0016319 mushroom body development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q7JUY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02645-1", "uniprot_id": "HTS_DROME", "mass": 127939.0, "length": 1156, "protein_name": "Protein hu-li tai shao", "gene_name": "hts", "organism": "Fruit fly", "refseq_name": "hu li tai shao, isoform H", "refseq_ac": "NP_001163203", "gene_names_uniprotkb": "hts; 1B1; ADD-87; Add-hts; Add1; Add2; Adducin; Add; CG34197; CG43443; CG9325; Dmel\\CG43443; Dmel_CG43443; EST D; HTS-R1; HTS-RC; HTS_DROME; HTS; Hts-RC; HtsF; HtsRC; Hts; Ovhts-RC; Ovhts; add-like; adducin; add; anon-EST:Posey9; htsRC; l(2)00634; l(2)01103; l(2)k06121; l(2)k14523; sxp", "gene_names_refseq": "1B1; ADD-87; Add-hts; Add1; Add2; Adducin; Add; CG34197; CG43443; CG9325; Dmel\\CG43443; EST D; HTS-R1; HTS-RC; HTS_DROME; HTS; Hts-RC; HtsF; HtsRC; Hts; Ovhts-RC; Ovhts; add-like; adducin; add; anon-EST:Posey9; htsRC; hts; l(2)00634; l(2)01103; l(2)k06121; l(2)k14523; sxp", "protein_names_uniprotkb": "Protein hu-li tai shao; Adducin-like protein", "protein_names_refseq": "Adducin-like 56D; Adducin-like-56D; CG43443-PH; Hu Li Tai shao; Hu li-tai shao; Hu-li tai shao; Hu-li tai-shao; adducin-like; hts-PH; hu li tai shao, isoform H; hu-li tai shao protein; hu-li-tai-shao; ovarian hu-li tai shao-ring canal protein", "tax_id": 7227, "disease": "spastic quadriplegic cerebral palsy 3 (Disease Ontology:DOID:0081361); hereditary spherocytosis type 1 (Disease Ontology:DOID:0110916); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hydrocephalus (Disease Ontology:DOID:10908); gastroschisis (Disease Ontology:DOID:11044); biliary atresia (Disease Ontology:DOID:13608); familial combined hyperlipidemia (Disease Ontology:DOID:13809); atherosclerosis (Disease Ontology:DOID:1936); cerebral palsy (Disease Ontology:DOID:1969); IgA glomerulonephritis (Disease Ontology:DOID:2986); temporal lobe epilepsy (Disease Ontology:DOID:3328); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG43443); (R-DME-264870); (R-DME-5223345); (R-DME-9035034)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10504343;10731132;12537568;12537569;12537572;12537573;12537574;1340461;16110336;17372656;17569856;17569867;18327897;23836506;25589440;26109356;26109357;7681599", "class_list": "", "function": "Required for assembling actin at ring canals in developing egg chambers. Probably interacts with other developmental proteins involved in nurse cell/oocyte transport through the ring canals. Important for normal neuromotor function (PubMed:23836506)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A1ZBK8;A4UZP6;E1JGM4;E1JGM6;Q8MQX6;Q9GNA8;Q9GZC1;Q9V8U4;Q9V8U5", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0061572 actin filament bundle organization;GO:0045214 sarcomere organization;GO:0007098 centrosome cycle;GO:0007411 axon guidance;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q02645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36193-1", "uniprot_id": "DROS_DROME", "mass": 7085.0, "length": 64, "protein_name": "Drosocin antimicrobial peptides", "gene_name": "Dro", "organism": "Fruit fly", "refseq_name": "drosocin, isoform B", "refseq_ac": "NP_001246324", "gene_names_uniprotkb": "Dro; 143609_at; BcDNA:RH31634; Btn; CG10816; DIM 11; DIM 15; DIM 9; DIM-15; DROC; Dmel\\CG10816; Dmel_CG10816; Drc; Dro1; Droc; Dros; Drs; IM15; IM7; drc; drosocin; dros; dro", "gene_names_refseq": "143609_at; BcDNA:RH31634; Btn; CG10816; DIM 11; DIM 15; DIM 9; DIM-15; DROC; Dmel\\CG10816; Drc; Dro1; Droc; Dros; Dro; Drs; IM15; IM7; drc; drosocin; dros; dro", "protein_names_uniprotkb": "Drosocin antimicrobial peptides; DIM 7; IM7", "protein_names_refseq": "CG10816-PB; Dro-PB; Immune-induced molecule 7; buletin; drosocin (D); drosocin precursor; drosocin, isoform B; drosophila immune induced molecule 11; drosophila immune induced molecule 15; drosophila immune induced molecule 9", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG10816)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12716986;16110336;17569856;17569867;25589440;26109356;26109357;35730150;36997646;36997647;8325867;8944755;9736738;9888811", "class_list": "", "function": "Antibacterial peptide with strong anti-Gram-negative bacteria activity (PubMed:8325867). Significantly contributes to antibacterial activity against Enterobacter cloacae but not Providencia burhodogranariea (PubMed:35730150). Inhibitor of bacterial translation machinery that targets translation termination in a prfA- or prfB-dependent manner (PubMed:36997646). Binds within the nascent peptide exit tunnel of the bacterial large ribosomal subunit, potentially interfering with nascent chain translocation that occurs post-peptide bond formation (PubMed:36997646, PubMed:36997647). Binds prfA/RF1 (and potentially prfB/RF2), trapping it on the ribosome after release of the nascent polypeptide chain and preventing further translation (PubMed:36997646). The resulting depletion of peptide chain release factors further disrupts bacterial translation by preventing ribosomal peptide chain release and inducing stop codon readthrough (PubMed:36997647). Entry into target Escherichia coli cells requires the bacterial peptide antibiotic transporter sbmA (PubMed:36997646)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Peptide with significant antibacterial activity against Providencia burhodogranariea but not Enterobacter cloacae., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 24, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZZ5;Q867T5;Q86BV9;Q9V749", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P36193-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10040-1", "uniprot_id": "CRB_DROME", "mass": 233572.0, "length": 2146, "protein_name": "Protein crumbs", "gene_name": "crb", "organism": "Fruit fly", "refseq_name": "crumbs, isoform B", "refseq_ac": "NP_001036751", "gene_names_uniprotkb": "crb; 04; 20; CG6383; CRB; CT19912; Crbs; Crb; Crumbs; DmCrb; Dmel\\CG6383; Dmel_CG6383; crumb; far; l(3)07207; l(3)S050920; l(3)S058104; l(3)j1B5", "gene_names_refseq": "0509/20; 1384/04; CG6383; CRB; CT19912; Crbs; Crb; Crumbs; DmCrb; Dmel\\CG6383; crb; crumb; far; l(3)07207; l(3)S050920; l(3)S058104; l(3)j1B5", "protein_names_uniprotkb": "Protein crumbs; 95F", "protein_names_refseq": "CG6383-PB; crb-PB; crumbs, isoform B; crumbs; fat rhabdomeres; lethal (3) 07207", "tax_id": 7227, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); Leber congenital amaurosis 8 (Disease Ontology:DOID:0110079); retinitis pigmentosa 12 (Disease Ontology:DOID:0110358); focal segmental glomerulosclerosis 9 (Disease Ontology:DOID:0111134); pigmented paravenous chorioretinal atrophy (Disease Ontology:DOID:0111541); ventriculomegaly - cystic kidney disease (Disease Ontology:DOID:0111625); retinitis pigmentosa (Disease Ontology:DOID:10584); Leber congenital amaurosis (Disease Ontology:DOID:14791); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (dme:Dmel_CG6383); (R-DME-1912420); (R-DME-9013700); (R-DME-9604323)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "10102271;10731132;11076972;11740560;12537568;12537569;12537572;12537573;12537574;12900452;16110336;17569856;17569867;17893096;20189678;2344615;25065591;25589440;26109356;26109357;30645584;3107986;32579558", "class_list": "", "function": "Plays a central role in cell polarity establishment, and contributes to the organization of zonula adherens, epithelial morphogenesis, and tissue growth (PubMed:10102271, PubMed:11740560, PubMed:12900452, PubMed:2344615). Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex (PubMed:10102271, PubMed:11076972, PubMed:11740560, PubMed:12900452). Controls the coalescence of the spots of zonula adherens (ZA) into an adhesive ring around the cells (PubMed:11740560). It may act as a signal (PubMed:2344615). Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina (PubMed:12900452). In cooperation with aPKC, required for the formation and maintenance of the rhabdomeric and stalk apical cortical membrane domains (PubMed:32579558). Recruits aPKC to the apical stalk membrane where it phosphorylates and displaces rhabdomere specifying proteins such as PIP82, to restrict their localization and thus activity to the rhabdomeric apical domain (PubMed:32579558). Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos (PubMed:25065591). The CGX complex is also required for cell proliferation in developing wing disks (PubMed:25065591). In the CGX complex, acts with galla-1 or galla-2 to recruit Xpd and thus form the functional complex. Together with apn, plays a key role in trachea development at larval stages (PubMed:30645584)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 35, "predicted_n_glycosites": 34, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 36, "binding_glycan_count": 0, "secondary_ac_list": "Q0KI19;Q8MSX5;Q9VC97", "ec_number_list": "", "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding;GO:0030507 spectrin binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0016332 establishment or maintenance of polarity of embryonic epithelium;GO:0051301 cell division;GO:0061024 membrane organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P10040-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KLV9-1", "uniprot_id": "PSD11_DROME", "mass": 47263.0, "length": 422, "protein_name": "26S proteasome non-ATPase regulatory subunit 11", "gene_name": "Rpn6", "organism": "Fruit fly", "refseq_name": "regulatory particle non-ATPase 6, isoform C", "refseq_ac": "NP_001246325", "gene_names_uniprotkb": "Rpn6; BcDNA.LD18931; BcDNA:LD18931; CG10149; CG5289; Dmel\\CG10149; Dmel_CG10149; Pros44.5; RPN6; S9; dPSMD11; l(2)k00103; p42B; rpn6", "gene_names_refseq": "BcDNA.LD18931; BcDNA:LD18931; CG10149; CG5289; Dmel\\CG10149; Pros44.5; RPN6; Rpn6; S9; dPSMD11; l(2)k00103; p42B; rpn6", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory complex subunit p42B; 26S proteasome regulatory subunit Rpn6", "protein_names_refseq": "CG10149-PC; Rpn6-PC; proteasome p44.5 subunit; regulatory particle non-ATPase 6, isoform C", "tax_id": 7227, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (dme:Dmel_CG10149); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-6798695); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 57, "publication_count": 48, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;10893261;11585911;12231619;12426099;12432393;12442174;12537568;12537569;12537572;12537573;12537574;12973300;15178801;15258584;15331761;16110336;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17569856;17569867;17925225;18327897;18519643;18593878;19185492;22187461;25589440;26109356;26109357;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly (By similarity). May act as linker between 19S regulatory subunit and the 20S proteasome core., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1Z9U3", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q7KLV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4Z8K6-1", "uniprot_id": "RBP9X_DROME", "mass": 106654.0, "length": 962, "protein_name": "Ran-binding proteins 9/10 homolog", "gene_name": "RanBPM", "organism": "Fruit fly", "refseq_name": "Ran-binding protein M, isoform D", "refseq_ac": "NP_001033938", "gene_names_uniprotkb": "RanBPM; CG11763; CG42236; Dmel\\CG42236; Dmel_CG42236; l(2)k05201", "gene_names_refseq": "CG11763; CG42236; Dmel\\CG42236; RanBPM; l(2)k05201", "protein_names_uniprotkb": "Ran-binding proteins 9/10 homolog; Ran-binding protein M", "protein_names_refseq": "CG42236-PD; Ran binding protein M; Ran-Binding protein in the microtubule organizing center; Ran-binding protein M, isoform D; Ran-binding proteins 9/10 homologue; RanBPM-PD; lethal (2) k05201", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42236); (R-DME-373760); (R-DME-9861718)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16055650;16110336;17569856;17569867;18327897;18762575;25589440;26109356;26109357;40245499", "class_list": "", "function": "May be involved in JAK/STAT signaling. Isoform D is required for the proper arrangement of niche cells and is autonomously required for proper niche cell size, isoform C negatively regulates the adhesive properties of the niche. The germline stem cell (GSC) niche in ovaries is made up of two somatic cell types: 8-9 cells in a single-filed array make up the terminal filament (TF), and a tight cluster of 5 or 6 cap cells (CpC). Regulating the size and adhesive properties of the CpCs is an important component of the mechanism that controls their capacity to support stem cells, isoform C and isoform D are important factors in mediating this regulation. In contrast, isoform C acts as a positive regulator of cell adhesion in follicle cell epithelium., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A1Z895;A1Z896;A8E757;Q6NN33;Q8T0U5;Q960F3", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0034657 GID complex", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0046827 positive regulation of protein export from nucleus;GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q4Z8K6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49415-1", "uniprot_id": "SDC_DROME", "mass": 42088.0, "length": 399, "protein_name": "Syndecan", "gene_name": "Sdc", "organism": "Fruit fly", "refseq_name": "syndecan, isoform A", "refseq_ac": "NP_476965", "gene_names_uniprotkb": "Sdc; CG10497; CT27296; Dmel\\CG10497; Dmel_CG10497; Dsyn; Syd; Syn; dSdc; l(2)10608; sdc; syd; syn", "gene_names_refseq": "CG10497; CT27296; Dmel\\CG10497; Dsyn; Sdc; Syd; Syn; dSdc; l(2)10608; sdc; syd; syn", "protein_names_uniprotkb": "Syndecan", "protein_names_refseq": "CG10497-PA; Sdc-PA; dSyndecan; syndecan, isoform A; syndecan", "tax_id": 7227, "disease": "bacterial infectious disease (Disease Ontology:DOID:104); familial hyperlipidemia (Disease Ontology:DOID:1168); lung adenocarcinoma (Disease Ontology:DOID:3910); hyperglycemia (Disease Ontology:DOID:4195); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); cleft palate (Disease Ontology:DOID:674); Hodgkin's lymphoma (Disease Ontology:DOID:8567); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG10497); (R-DME-1971475); (R-DME-2022928); (R-DME-2024096); (R-DME-3000170); (R-DME-381426); (R-DME-3928662); (R-DME-8957275); (R-DME-9769739)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14761655;16110336;17569856;17569867;25589440;26109356;26109357;8159748", "class_list": "", "function": "Cell surface proteoglycan that bears heparan sulfate. Required for axonal and myotube guidance, is a necessary component of slit/robo signaling and is required in the slit target cells., [UniProtKB, PubMed, PubMed]; Cell surface proteoglycan., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 1, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8Z8;Q8SXJ0;Q9W2G7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0045202 synapse", "go_biological_process": "GO:0021782 glial cell development;GO:0016477 cell migration;GO:0007517 muscle organ development;GO:0045887 positive regulation of synaptic assembly at neuromuscular junction;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P49415-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K2Y9-1", "uniprot_id": "NTAQ1_DROME", "mass": 24006.0, "length": 205, "protein_name": "Protein N-terminal glutamine amidohydrolase", "gene_name": "tun", "organism": "Fruit fly", "refseq_name": "tungus, isoform B", "refseq_ac": "NP_001246351", "gene_names_uniprotkb": "tun; BcDNA:LD38553; CG8253; Dmel\\CG8253; Dmel_CG8253; Ntaq1", "gene_names_refseq": "BcDNA:LD38553; CG8253; Dmel\\CG8253; Ntaq1; tun", "protein_names_uniprotkb": "Protein N-terminal glutamine amidohydrolase; 3.5.1.122; N-terminal Gln amidase; Nt(Q)-amidase; Protein NH2-terminal glutamine deamidase; Protein tungus", "protein_names_refseq": "CG8253-PB; tun-PB; tungus, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8253)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12593794;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.122", "go_molecular_function": "GO:0008418 protein-N-terminal asparagine amidohydrolase activity;GO:0070773 protein-N-terminal glutamine amidohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7K2Y9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07187-1", "uniprot_id": "LCP2_DROME", "mass": 13488.0, "length": 126, "protein_name": "Larval cuticle protein 2", "gene_name": "Lcp2", "organism": "Fruit fly", "refseq_name": "larval cuticle protein 2, isoform B", "refseq_ac": "NP_001260802", "gene_names_uniprotkb": "Lcp2; 2; CG8697; CP2; DmelLcp2; Dmel\\CG8697; Dmel_CG8697; II; LCP-2; LCP2; L[[3]]CP2; lcp2", "gene_names_refseq": "2; CG8697; CP2; DmelLcp2; Dmel\\CG8697; II; LCP-2; LCP2; L[[3]]CP2; Lcp2; lcp2", "protein_names_uniprotkb": "Larval cuticle protein 2; Larval cuticle protein II", "protein_names_refseq": "CG8697-PB; Lcp2-PB; cuticle p. II; gene II; larval cuticle protein 2, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8697)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;6817923", "class_list": "", "function": "Component of the larval cuticle., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0HBT8;Q9V4T0", "ec_number_list": "", "go_molecular_function": "GO:0008010 structural constituent of chitin-based larval cuticle;GO:0042302 structural constituent of cuticle", "go_cellular_component": "GO:0062129 chitin-based extracellular matrix", "go_biological_process": "GO:0008363 larval chitin-based cuticle development;GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07187-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18289-1", "uniprot_id": "JRA_DROME", "mass": 31021.0, "length": 289, "protein_name": "Transcription factor Jra", "gene_name": "Jra", "organism": "Fruit fly", "refseq_name": "Jun-related antigen, isoform A", "refseq_ac": "NP_476586", "gene_names_uniprotkb": "Jra; AP-1; AP1; Ap-1; Ap1; CG2275; D-Jun; D-jun; D.Jun; DJUN; DJun; DM14; Djun; Dmel\\CG2275; Dmel_CG2275; JRA; JUN; Jra; Jun; V; c-Jun; cJun; cjun; d-JRA; d-Jun; d-jun; dAP-1; dJRA; dJUN; dJra; dJun; djun; dm-Jun; jra; jun; l(2)46Ef; l(2)IA109; l(2R)IA109", "gene_names_refseq": "AP-1; AP1; Ap-1; Ap1; CG2275; D-Jun; D-jun/Jra; D-jun; D.Jun; DJUN; DJun; DM14; Djun; Dmel\\CG2275; JRA; JUN; Jra; Jun; V; c-Jun; cJun; cjun; d-JRA; d-Jun; d-jun; dAP-1; dJRA; dJUN; dJra; dJun; djun; dm-Jun; jra; jun; l(2)46Ef; l(2)IA109; l(2R)IA109", "protein_names_uniprotkb": "Transcription factor Jra; Jun-related antigen; Transcription factor AP-1 subunit Jra; dJRA; dJun", "protein_names_refseq": "CG2275-PA; Jra-PA; Jun oncogene; Jun related antigen; Jun-related antigen, isoform A; Jun; activator protein 1; complementation group V; lethal(2)1A109; lethal(2)IA109", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); anaplastic large cell lymphoma (Disease Ontology:DOID:0050744); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); crescentic glomerulonephritis (Disease Ontology:DOID:13139); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); pulmonary tuberculosis (Disease Ontology:DOID:2957); gallbladder cancer (Disease Ontology:DOID:3121); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); renal carcinoma (Disease Ontology:DOID:4451); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); Hodgkin's lymphoma (Disease Ontology:DOID:8567); systemic lupus erythematosus (Disease Ontology:DOID:9074); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dme:Dmel_CG2275); (R-DME-209394); (R-DME-209409); (R-DME-209425)", "pathway_count": 4, "publication_count": 33, "publication_id_list": "10028968;10409696;10572048;10731132;10903185;11269501;11865058;12537568;12537569;12537572;12537573;12537574;12732719;15640802;16110336;1696724;17372656;1749429;17569856;17569867;17803358;1922387;20023169;2116361;25589440;26109356;26109357;28604694;40245499;7816143;8946915;8946916;9224723", "class_list": "", "function": "Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:1696724, PubMed:2116361). Plays a role in dorsal closure (PubMed:9224723)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 29, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0E9D8;Q9V5G4", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050829 defense response to Gram-negative bacterium;GO:0051124 synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P18289-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05552-1", "uniprot_id": "ADF1_DROME", "mass": 30188.0, "length": 262, "protein_name": "Transcription factor Adf-1", "gene_name": "Adf1", "organism": "Fruit fly", "refseq_name": "Adh transcription factor 1, isoform A", "refseq_ac": "NP_724481", "gene_names_uniprotkb": "Adf1; ADF1; ADF; Adf 1; Adf-1; Adf; CG15845; Dmel\\CG15845; Dmel_CG15845; adf-1; adf1; l(2)01349; l(2)04065; l(2)k14805; nal", "gene_names_refseq": "ADF1; ADF; Adf 1; Adf-1; Adf1; Adf; CG15845; Dmel\\CG15845; adf-1; adf1; l(2)01349; l(2)04065; l(2)k14805; nal", "protein_names_uniprotkb": "Transcription factor Adf-1; ADH distal factor 1", "protein_names_refseq": "Adf1-PA; Adh transcription factor 1, isoform A; CG15845-PA; lethal (2) k14805; nalyot; naylot", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15845)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;1731341;17569856;17569867;2318884;25589440;26109356;26109357", "class_list": "", "function": "May play an important role not only in the regulation of Adh expression but also in the transcription of other genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E9N5;Q9V9C4", "ec_number_list": "", "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0005705 polytene chromosome interband", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007611 learning or memory;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P05552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24318-1", "uniprot_id": "TFDP_DROME", "mass": 49750.0, "length": 445, "protein_name": "Transcription factor Dp", "gene_name": "Dp", "organism": "Fruit fly", "refseq_name": "DP transcription factor, isoform A", "refseq_ac": "NP_477039", "gene_names_uniprotkb": "Dp; 49Fk; CG4654; DDP1; DP1; DP; DmDP; Dmel\\CG4654; Dmel_CG4654; Dp1; TFPD2; dDP1; dDP; dDp; dp; l(2)49Fk; l(2)vr10; vr10", "gene_names_refseq": "49Fk; CG4654; DDP1; DP1; DP; DmDP; Dmel\\CG4654; Dp1; Dp; TFPD2; dDP1; dDP; dDp; dp; l(2)49Fk; l(2)vr10; vr10", "protein_names_uniprotkb": "Transcription factor Dp", "protein_names_refseq": "CG4654-PA; DP transcription factor, isoform A; Dp-PA; dimerization partner; lethal(2)49Fk", "tax_id": 7227, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182)", "pathway": " (dme:Dmel_CG4654); (R-DME-1538133); (R-DME-2173796); (R-DME-69231); (R-DME-8953750)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15479636;15545624;16110336;17569856;17569867;18327897;25589440;26109356;26109357;40245499;8022787;9271122", "class_list": "", "function": "Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes. Can stimulate E2F-dependent transcription., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B8A3X4;O17472;O44080;Q86PE0;Q8ML56;Q9V6M0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031523 Myb complex;GO:0035189 Rb-E2F complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q24318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05733-1", "uniprot_id": "DCHS_DROME", "mass": 94036.0, "length": 847, "protein_name": "Histidine decarboxylase", "gene_name": "Hdc", "organism": "Fruit fly", "refseq_name": "histidine decarboxylase, isoform B", "refseq_ac": "NP_001260855", "gene_names_uniprotkb": "Hdc; CG3454; Dmel\\CG3454; Dmel_CG3454; HDC; JK910; anon-WO0140519.259; hdc", "gene_names_refseq": "CG3454; Dmel\\CG3454; HDC; Hdc; JK910; anon-WO0140519.259; hdc", "protein_names_uniprotkb": "Histidine decarboxylase; 4.1.1.22; HDC", "protein_names_refseq": "CG3454-PB; Hdc-PB; histidine decarboxylase, isoform B; histidine decarboxylase; histidine-decarboxylase", "tax_id": 7227, "disease": "Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (dme:Dmel_CG3454); (R-DME-70921)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499;8096176", "class_list": "", "function": "Required in photoreceptor transmitter synthesis (PubMed:8096176). Catlayzes the conversion of L-histidine to histamine (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9V5I3", "ec_number_list": "4.1.1.22", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004398 histidine decarboxylase activity", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006548 L-histidine catabolic process;GO:0001694 histamine biosynthetic process;GO:0042423 catecholamine biosynthetic process;GO:0043052 thermotaxis;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q05733-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1LZ08-1", "uniprot_id": "WDR48_DROME", "mass": 75266.0, "length": 668, "protein_name": "WD repeat-containing protein 48 homolog", "gene_name": "Uaf1", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_725018", "gene_names_uniprotkb": "Uaf1; CG9062; Dmel\\CG9062; Dmel_CG9062", "gene_names_refseq": "CG9062; Dmel\\CG9062", "protein_names_uniprotkb": "WD repeat-containing protein 48 homolog; USP1-associated factor 1", "protein_names_refseq": "CG9062-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9062); (R-DME-110314); (R-DME-5689880)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;37798281", "class_list": "", "function": "Regulatory component of the Usp12-46 deubiquitylase complex (PubMed:37798281). activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity). The complex deubiquitylates the wg/wingless-signaling receptor arr/arrow, which stabilizes the receptor and increases its concentration at the cell surface; this enhances the sensitivity of cells to wg/wingless-signal stimulation (PubMed:37798281). This increases the amplitude and spatial range of the signaling response to the wg/wingless morphogen gradient, facilitating the precise concentration-dependent regulation of its target genes (PubMed:37798281). Together with Wdr20 and Usp12-46 required for wg/wingless-mediated signaling in the wing imaginal disc and for wg/wingless-dependent regulation of intestinal stem cell proliferation (PubMed:37798281)., [UniProtKB, UniProtKB, PubMed]; Regulatory component of the Usp12-46 deubiquitylase complex. activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. The complex deubiquitylates the wg/wingless-signaling receptor arr/arrow, which stabilizes the receptor and increases its concentration at the cell surface; this enhances the sensitivity of cells to wg/wingless-signal stimulation. This increases the amplitude and spatial range of the signaling response to the wg/wingless morphogen gradient, facilitating the precise concentration-dependent regulation of its target genes. Together with Wdr20 and Usp12-46 required for wg/wingless-mediated signaling in the wing imaginal disc and for wg/wingless-dependent regulation of intestinal stem cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGK7", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding;GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:1905368 peptidase complex", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0000724 double-strand break repair via homologous recombination;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q1LZ08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7M3M8-1", "uniprot_id": "CAS_DROME", "mass": 87925.0, "length": 793, "protein_name": "Transcription factor castor", "gene_name": "cas", "organism": "Fruit fly", "refseq_name": "castor, isoform A", "refseq_ac": "NP_524677", "gene_names_uniprotkb": "cas; CAS; CG2102; Cas; Dmel\\CG2102; Dmel_CG2102; l(3)j1C2; l(3)neo33; ming", "gene_names_refseq": "CAS; CG2102; Cas; Dmel\\CG2102; cas; l(3)j1C2; l(3)neo33; ming", "protein_names_uniprotkb": "Transcription factor castor; Protein ming", "protein_names_refseq": "CG2102-PA; cas-PA; castor, isoform A; castor", "tax_id": 7227, "disease": "chromosome 1p36 deletion syndrome (Disease Ontology:DOID:0060410)", "pathway": " (dme:Dmel_CG2102)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10731132;11335107;12537568;12537569;12537572;12537573;12537574;1339340;1418995;16110336;17372656;17569856;17569867;25589440;26109356;26109357;7588058;9436984", "class_list": "", "function": "Transcription factor that specifies expression of key genes in developing central nervous system (CNS). Essential for many, if not all, late developing neuroblastoma (NB) sublineages. Binds to the 5'-[CG]C[CT][CT]AAAAA[AT]-3' DNA sequence, like hb, suggesting that cas and hb act as a late regulators in early and late CNS NB sublineage, respectively. Acts by repressing expression of nub/pdm-1 and pdm2/pdm-2 POU genes, and restrict their pattern of expression in appropriate cells. Required for a full expression of vvl/drifter and acj6/I-POU; it is however unknown whether it directly activates these genes. Controls engrailed (en) expression in the ventral nerve cord., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VNH0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0007402 ganglion mother cell fate determination;GO:0021782 glial cell development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q7M3M8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49905-1", "uniprot_id": "TAF12_DROME", "mass": 21523.0, "length": 196, "protein_name": "Transcription initiation factor TFIID subunit 12", "gene_name": "Taf12", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 12, isoform E", "refseq_ac": "NP_001262479", "gene_names_uniprotkb": "Taf12; 22; 28; CG17358; Dmel\\CG17358; Dmel_CG17358; T2DA_DROME; TAF12; TAF30-ALPHA; TAF30alpha; TAF30a; TAF[II]30alpha; TAF[[II]]230; TAF[[II]]30alpha; TAF[[II]]; TAF; TFIID 22; TFIID 28; TFIID-p28; TFIID; Taf22; Taf28; Taf30alpha; Taf32; Taf[[II]]30alpha; dTAF12; dTAF22; dTAF28; dTAFII30 alpha; dTAFII30; dTAF[[II]]30alpha; dTAF[[II]]30; dTaf12; dmTAF12; p22; p28; taf12", "gene_names_refseq": "CG17358; Dmel\\CG17358; T2DA_DROME; TAF12; TAF30alpha/28/22; TAF30alpha/28; TAF30alpha; TAF30a; TAFII30alpha/22; TAF[II]30alpha; TAF[[II]]230; TAF[[II]]30alpha/28 TAF[[II]]22; TAF[[II]]30alpha/28/22; TAF[[II]]30alpha; TAF[[II]]; TAF; TFIID 22; TFIID 28; TFIID-p28; TFIID; Taf12; Taf22; Taf28; Taf30alpha; Taf32; Taf[[II]]30alpha; d28/22; dTAF12; dTAF22; dTAF28; dTAFII30 alpha; dTAFII30; dTAF[[II]]30alpha/22; dTAF[[II]]30alpha; dTAF[[II]]30; dTaf12; dmTAF12; p22; p28; taf12", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 12; TAFII30 alpha; Transcription initiation factor TFIID 28-alpha kDa/22 kDa subunits; p28-alpha/p22", "protein_names_refseq": "26kDa polypeptide; CG17358-PE; TBP-associated factor 12, isoform E; TBP-associated factor 30kD subunit alpha; Taf12-PE", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17358); (R-DME-674695); (R-DME-6804756); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7545910;8276241", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2Q1;Q26339;Q9VGK0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P49905-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23023-1", "uniprot_id": "DSX_DROME", "mass": 57409.0, "length": 549, "protein_name": "Protein doublesex", "gene_name": "dsx", "organism": "Fruit fly", "refseq_name": "doublesex, isoform D", "refseq_ac": "NP_001262352", "gene_names_uniprotkb": "dsx; CG11094; DSXF; DSXM; DSX; Dmdsx; Dmel\\CG11094; Dmel_CG11094; Dsx; Hr; dsxF; dsxM; ix-62c", "gene_names_refseq": "CG11094; DSXF; DSXM; DSX; Dmdsx; Dmel\\CG11094; Dsx; Hr; dsxF; dsxM; dsx; ix-62c", "protein_names_uniprotkb": "Protein doublesex", "protein_names_refseq": "CG11094-PD; double sex; doublesex, isoform D; doublesex; dsx-PD; hermaphrodite; intersex-62c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11094)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12435630;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;1907913;2493994;25589440;26109356;26109357;8440242", "class_list": "", "function": "Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P23022;Q0KIA7;Q95TA5;Q9VHY0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007530 sex determination;GO:0008049 male courtship behavior;GO:0046661 male sex differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P23023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IN94-1", "uniprot_id": "OSA_DROME", "mass": 284064.0, "length": 2716, "protein_name": "Trithorax group protein osa", "gene_name": "osa", "organism": "Fruit fly", "refseq_name": "osa, isoform D", "refseq_ac": "NP_001163639", "gene_names_uniprotkb": "osa; 4H; ARID1B; C819; CG7467; Dmel\\CG7467; Dmel_CG7467; E(E2F)3C; OSA; Osa; anon-WO0118547.314; anon-WO0172774.126; eld; eyelid; l(3)00090; l(3)04539; l(3)j9C3; p300", "gene_names_refseq": "ARID1B; C819; CG7467; Dmel\\CG7467; E(E2F)3C; OSA; Osa; anon-WO0118547.314; anon-WO0172774.126; eld; en(lz)4F/4H; eyelid; l(3)00090; l(3)04539; l(3)j9C3; osa; p300", "protein_names_uniprotkb": "Trithorax group protein osa; Protein eyelid", "protein_names_refseq": "CG7467-PD; eye lid; eyelid; osa, isoform D; osa-PD", "tax_id": 7227, "disease": "ovarian clear cell carcinoma (Disease Ontology:DOID:0050934); autism spectrum disorder (Disease Ontology:DOID:0060041); Coffin-Siris syndrome 1 (Disease Ontology:DOID:0070042); Coffin-Siris syndrome 2 (Disease Ontology:DOID:0070044); stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); Coffin-Siris syndrome (Disease Ontology:DOID:1925); colon cancer (Disease Ontology:DOID:219); endometrial adenocarcinoma (Disease Ontology:DOID:2870); ischemia (Disease Ontology:DOID:326); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophagus adenocarcinoma (Disease Ontology:DOID:4914); Klatskin's tumor (Disease Ontology:DOID:4927); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dme:Dmel_CG7467); (R-DME-3214858); (R-DME-8939243); (R-DME-9933937); (R-DME-9933946); (R-DME-9934037)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "10471712;10601025;10731132;10809665;11124806;12537568;12537572;12537573;12537574;12629041;16110336;17569856;17569867;18327897;25589440;26109356;26109357;9271118;9895321", "class_list": "", "function": "Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. Required for the activation of genes such as Antp, Ubx and Eve. Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins. Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. Acts as an essential coactivator for Zeste, which recruits the whole complex to specific genes. In contrast, it acts as a corepressor for Wg target genes, possibly via an interaction with Pan and Gro. It also acts as a negative regulator for proneural achaete-scute, when it is directly recruited by Pan and Chi. Also represses E2f activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O61603;Q9VEG7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071565 nBAF complex;GO:0035060 brahma complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8IN94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05049-1", "uniprot_id": "SNAK_DROME", "mass": 48458.0, "length": 435, "protein_name": "Serine protease snk", "gene_name": "snk", "organism": "Fruit fly", "refseq_name": "snake, isoform B", "refseq_ac": "NP_001097766", "gene_names_uniprotkb": "snk; CG7996; Dmel\\CG7996; Dmel_CG7996; SNK; SP26; Snk; c-SP26; cSP26; l(3)87Dg; me(3)4", "gene_names_refseq": "CG7996; Dmel\\CG7996; SNK; SP26; Snk; c-SP26; cSP26; l(3)87Dg; me(3)4; snk", "protein_names_uniprotkb": "Serine protease snk; 3.4.21.-; Protein snake", "protein_names_refseq": "CG7996-PB; snake, isoform B; snake; snk-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7996); (R-DME-209442)", "pathway_count": 2, "publication_count": 29, "publication_id_list": "10731132;11296245;11350927;11486795;11493599;12493753;12537568;12537572;12537573;12537574;12872120;14667416;14685264;15197269;15795223;16110336;16399077;16996061;17324925;17569856;17569867;18347020;20605458;25589440;26109356;26109357;8026333;9477324;9533958", "class_list": "", "function": "Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo (PubMed:11486795). A protease cascade involving ndl, gd, snk and ea results in activation of the spz Toll receptor ligand; acts downstream of ndl and gd (PubMed:20605458). Activation of ea requires both activation of the ndl-gd-snk protease cascade and sulfation of a vitelline membrane component by pip (PubMed:20605458). Localized activation of the Toll receptor in the ventral region of the embryo defines cell identities along the dorsal-ventral continuum (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29QH0;Q9VFZ7", "ec_number_list": "3.4.21.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0031638 zymogen activation;GO:0009950 dorsal/ventral axis specification;GO:0160032 Toll receptor ligand protein activation cascade", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P05049-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54359-1", "uniprot_id": "SEPT2_DROME", "mass": 48474.0, "length": 419, "protein_name": "Septin-2", "gene_name": "Septin2", "organism": "Fruit fly", "refseq_name": "septin 2, isoform A", "refseq_ac": "NP_524417", "gene_names_uniprotkb": "Septin2; 38961; CG4173; DSep2; Dmel\\CG4173; Dmel_CG4173; Sep2; dSEPT2; sep2", "gene_names_refseq": "38961; CG4173; DSep2; Dmel\\CG4173; Sep2; Septin2; dSEPT2; sep2", "protein_names_uniprotkb": "Septin-2", "protein_names_refseq": "CG4173-PA; Septin2-PA; septin 2, isoform A; septin 2; septin-2; septin2", "tax_id": 7227, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dme:Dmel_CG4173)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in cytokinesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24092;Q9VDK8", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0042461 photoreceptor cell development;GO:0042060 wound healing;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P54359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27368-1", "uniprot_id": "E2F1_DROME", "mass": 87460.0, "length": 805, "protein_name": "Transcription factor E2f1", "gene_name": "E2f1", "organism": "Fruit fly", "refseq_name": "E2F transcription factor 1, isoform F", "refseq_ac": "NP_001287455", "gene_names_uniprotkb": "E2f1; CG6376; DmE2F-1; Dmel\\CG6376; Dmel_CG6376; Dp; E(Sev-CycE)3A; E(var)3-93E; E(var)3-95E; E(var)93E; E2F-1; E2F1; E2F; E2f; Evar(3)164; dE2F1; dE2F; dE2f1; dE2f; de2f1; def21; drosE2F1; e2f1; e2f; l(3)07172; l(3)j3B1; l(3)j3C2; l(3)rM729", "gene_names_refseq": "CG6376; DRTF1/E2F; DmE2F-1; Dmel\\CG6376; Dp; E(Sev-CycE)3A; E(var)3-93E; E(var)3-95E; E(var)93E; E2F-1; E2F1; E2F; E2f1; E2f; Evar(3)164; dE2F1; dE2F; dE2f1; dE2f; de2f1; def21; drosE2F1; e2f1; e2f; l(3)07172; l(3)j3B1; l(3)j3C2; l(3)rM729", "protein_names_uniprotkb": "Transcription factor E2f1; dE2F", "protein_names_refseq": "CG6376-PF; E2-promoter binding factor; E2F transcription factor 1, isoform F; E2F transcription factor; E2f1-PF", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); dementia (Disease Ontology:DOID:1307); pancreatic cancer (Disease Ontology:DOID:1793); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); lung small cell carcinoma (Disease Ontology:DOID:5409); viral encephalitis (Disease Ontology:DOID:646); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG6376); (R-DME-1538133); (R-DME-2173796); (R-DME-68911); (R-DME-69231); (R-DME-8953750)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;14526388;16110336;17569856;17569867;18327897;19081076;25589440;26109356;26109357;8022787;8114698;8537434;9271122;9418862;9858578", "class_list": "", "function": "Transcriptional activator that binds to E2f sites. Required for wild-type growth in mitotic and polytene tissues, Contributes to the expression of replication genes at the G1-S transition and Cyclin E. Activates cell proliferation in wing imaginal disk, which requires expression of vg., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O77035;Q5U0Z6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0035189 Rb-E2F complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:1900117 regulation of execution phase of apoptosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q27368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24208-1", "uniprot_id": "IF2G_DROME", "mass": 51485.0, "length": 475, "protein_name": "Eukaryotic translation initiation factor 2 subunit 3", "gene_name": "eIF2gamma", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 2 subunit gamma, isoform D", "refseq_ac": "NP_001262587", "gene_names_uniprotkb": "eIF2gamma; 51kDa protein; CG43665; CG6476; Dmel\\CG43665; Dmel_CG43665; eIF-2G; eIF-2gamma; eIF2-gamma; eIF2G; eIF2g", "gene_names_refseq": "51kDa protein; CG43665; CG6476; Dmel\\CG43665; eIF-2G; eIF-2gamma; eIF2-gamma; eIF2G; eIF2gamma", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma; eIF2-gamma", "protein_names_refseq": "CG43665-PD; eIF2gamma-PD; eukaryotic initiation factor 2gamma; eukaryotic translation initiation factor 2 subunit gamma, isoform D; gamma subunit of the translation initiation factor eIF2", "tax_id": 7227, "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); leukodystrophy (Disease Ontology:DOID:10579); glucose metabolism disease (Disease Ontology:DOID:4194); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (dme:Dmel_CG43665); (R-DME-156827); (R-DME-381042); (R-DME-382556); (R-DME-72649); (R-DME-72695); (R-DME-72702); (R-DME-72731); (R-DME-9840373)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "10731132;11063691;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7915232", "class_list": "", "function": "As a subunit of eukaryotic initiation factor 2 eIF2, involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VFA7", "ec_number_list": "3.6.5.5;3.6.5.2;3.6.5.-;3.6.4.13;3.6.5.3;2.7.11.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003743 translation initiation factor activity;GO:1990856 methionyl-initiator methionine tRNA binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0043614 multi-eIF complex;GO:0005850 eukaryotic translation initiation factor 2 complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KS38-1", "uniprot_id": "RS19B_DROME", "mass": 17362.0, "length": 155, "protein_name": "Small ribosomal subunit protein eS19B", "gene_name": "RpS19b", "organism": "Fruit fly", "refseq_name": "ribosomal protein S19b, isoform C", "refseq_ac": "NP_001262891", "gene_names_uniprotkb": "RpS19b; BcDNA:SD22440; CG5338; Dmel\\CG5338; Dmel_CG5338; RPS19b; RpS19; rpS19", "gene_names_refseq": "BcDNA:SD22440; CG5338; Dmel\\CG5338; RPS19b; RpS19b; RpS19; rpS19", "protein_names_uniprotkb": "Small ribosomal subunit protein eS19B; 40S ribosomal protein S19b", "protein_names_refseq": "CG5338-PC; RpS19b-PC; ribosomal protein S19b, isoform C; ribosomal protein S19", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 1 (Disease Ontology:DOID:0111895); aplastic anemia (Disease Ontology:DOID:12449); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (dme:Dmel_CG5338)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022627 cytosolic small ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7KS38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09087-1", "uniprot_id": "ABDB_DROME", "mass": 55096.0, "length": 493, "protein_name": "Homeobox protein abdominal-B", "gene_name": "Abd-B", "organism": "Fruit fly", "refseq_name": "abdominal B, isoform J", "refseq_ac": "NP_001303471", "gene_names_uniprotkb": "Abd-B; 9; ABD-B; ABDB; Abd B; Abd-b; Abd0B; AbdB(CA)[[26]]; AbdB-II; AbdB-I; AbdBm; AbdB; Abdb; Adb-B; AdbB; BX-C; CG10291; CG11648; DROABDB; DmAbdB; Dmel\\CG11648; Dmel_CG11648; Droabdb; FAB; Fab-6; Fab-7; Fab-8; Fab6; Fab7; IAB 5; IAB5; IAB7; IAB8; Iab-7; MCP; Mcp; Mc; Sab; Tab; Uab-5[Sab]; abd-B; abdB; bex; iab-5; iab-6; iab-7; iab-8; iab5; iab6; iab7; iab8.9; iab8; iab9; iab; l(3)89Ed; pH189; tuh-3; twig", "gene_names_refseq": "9; ABD-B; ABDB; Abd B; Abd-B; Abd-b; Abd0B; AbdB(CA)[[26]]; AbdB-II; AbdB-I; AbdBm; AbdB; Abdb; Adb-B; AdbB; BX-C; CG10291; CG11648; DROABDB; DmAbdB; Dmel\\CG11648; Droabdb; FAB; Fab-6; Fab-7; Fab-8; Fab6; Fab7; IAB 5; IAB5; IAB7; IAB8; Iab-7; MCP; Mcp; Mc; Sab; Tab; Uab-5[Sab]; abd-B; abdB; bex; iab-5; iab-6; iab-7; iab-8; iab5; iab6; iab7; iab8.9; iab8/9; iab8; iab9; iab; l(3)89Ed; pH189; tuh-3; twig", "protein_names_uniprotkb": "Homeobox protein abdominal-B; IAB-7; Infraabdominal 7; P3; PH189", "protein_names_refseq": "Abd-B-PJ; Abdominal-B; AbdominalB; CG11648-PJ; abdominal B, isoform J; abdominal-A; corset; infra-abdominal 5; infra-abdominal 6; infra-abdominal 7; infra-abdominal 8; infra-abdominal 9; infraabdominal-8.9; male chauvinist pigmentation; microcephalus; miscadastral pigmentation; superabdominal; transabdominal", "tax_id": 7227, "disease": "congenital vertical talus (Disease Ontology:DOID:0111568); radioulnar synostosis (Disease Ontology:DOID:9827)", "pathway": " (dme:Dmel_CG11648)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2416463;2482824;25589440;2575066;26109356;26109357;2903049;2903050;7667301", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VEQ8;Q9VEQ9", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005704 polytene chromosome band", "go_biological_process": "GO:0030540 female genitalia development;GO:0007621 negative regulation of female receptivity;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P09087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61849-1", "uniprot_id": "NEMS_DROME", "mass": 11070.0, "length": 100, "protein_name": "Dromyosuppressin", "gene_name": "Ms", "organism": "Fruit fly", "refseq_name": "myosuppressin, isoform B", "refseq_ac": "NP_001262911", "gene_names_uniprotkb": "Ms; CG6440; DMS; Dm-MS; Dmel\\CG6440; Dmel_CG6440; Dms; Drm-MS; Drome-MS; FLRFa; MEMS; MS; Nems; cg6440; dms", "gene_names_refseq": "CG6440; DMS; Dm-MS; Dmel\\CG6440; Dms; Drm-MS; Drome-MS; FLRFa; MEMS; MS; Ms; Nems; cg6440; dms", "protein_names_uniprotkb": "Dromyosuppressin; TDVDHVFLRFamide", "protein_names_refseq": "CG6440-PB; Drm-myosuppressin; Ms-PB; TDVDHVFLRFamide; dromyosuppressin; myosuppressin, isoform B; myosuppressin; neomyosuppressin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6440)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12171930;12537568;12537569;12537572;12537573;12537574;1390001;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Myoinhibiting neuropeptide., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P41494;Q9VC91", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0071855 neuropeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008344 adult locomotory behavior;GO:0010459 negative regulation of heart rate;GO:0045986 negative regulation of smooth muscle contraction;GO:0045822 negative regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P61849-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O97176-1", "uniprot_id": "ESM1_DROME", "mass": 17339.0, "length": 156, "protein_name": "Enhancer of split M1 protein", "gene_name": "Kaz-m1", "organism": "Fruit fly", "refseq_name": "Kazal-type protease inhibitor m1, isoform B", "refseq_ac": "NP_001262980", "gene_names_uniprotkb": "Kaz-m1; BcDNA:RE44854; CG8342; Dmel\\CG8342; Dmel_CG8342; E(spl)-m1; E(spl)m1; HLHm1; lincRNA.856; m1", "gene_names_refseq": "BcDNA:RE44854; CG8342; Dmel\\CG8342; E(spl)-m1; E(spl)m1; HLHm1; Kaz-m1; lincRNA.856; m1", "protein_names_uniprotkb": "Enhancer of split M1 protein; E(spl)m1; Kazal-type protease inhibitor m1", "protein_names_refseq": "CG8342-PB; E(spl) region transcript m1; Kaz-m1-PB; Kazal-type protease inhibitor m1, isoform B; Kazal-type protease inhibitor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8342)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10072784;10731132;10903170;12537568;12537569;12537572;12537573;12537574;15537803;16110336;16356268;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56LL2;Q56LL5;Q56LP9;Q56LS4;Q56LS6;Q56LX2;Q56LX7;Q56LZ2;Q56LZ7;Q56M22;Q56M82;Q56MB6;Q56MB7;Q56MC4;Q56MH8;Q56MI0;Q56MI2;Q56MI3;Q56MJ1;Q5S421;Q5S481;Q5S4G5;Q5S4I9;Q5S4L3", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "O97176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52168-1", "uniprot_id": "PNR_DROME", "mass": 57036.0, "length": 540, "protein_name": "GATA-binding factor A", "gene_name": "pnr", "organism": "Fruit fly", "refseq_name": "pannier, isoform A", "refseq_ac": "NP_476685", "gene_names_uniprotkb": "pnr; CG3978-PA; CG3978; Dmel\\CG3978; Dmel_CG3978; GATA-A; GATA4; GATAa; GATA; PNR; Pannier; Pnr; dGATAa; l(3)89B3; pannier; prn", "gene_names_refseq": "CG3978-PA; CG3978; Dmel\\CG3978; GATA4; GATAa/Pannier; GATAa; GATA; PNR; Pnr; dGATAa/pannier; dGATAa; l(3)89B3; pnr; prn", "protein_names_uniprotkb": "GATA-binding factor A; Protein pannier; Transcription factor GATA-A; dGATA-A", "protein_names_refseq": "CG3978-PA; pannier, isoform A; pannier; pnr-PA", "tax_id": 7227, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); atrioventricular septal defect (Disease Ontology:DOID:0050651); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); atrial fibrillation (Disease Ontology:DOID:0060224); bicuspid aortic valve disease (Disease Ontology:DOID:0080332); atrial heart septal defect 2 (Disease Ontology:DOID:0110107); atrial heart septal defect 9 (Disease Ontology:DOID:0110114); pancreatic hypoplasia-diabetes-congenital heart disease syndrome (Disease Ontology:DOID:0111733); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); Klatskin's tumor (Disease Ontology:DOID:4927); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); pulmonary hypertension (Disease Ontology:DOID:6432); Barrett's esophagus (Disease Ontology:DOID:9206); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dme:Dmel_CG3978); (R-DME-5683826); (R-DME-983231)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;11290303;12537568;12537572;12537573;12537574;12629041;16110336;17569856;17569867;25589440;26109356;26109357;7916677;7916679", "class_list": "", "function": "Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P52168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25992-1", "uniprot_id": "YEMA_DROME", "mass": 109311.0, "length": 1002, "protein_name": "yemanuclein", "gene_name": "yem", "organism": "Fruit fly", "refseq_name": "yemanuclein, isoform A", "refseq_ac": "NP_476893", "gene_names_uniprotkb": "yem; CG11879; CG14513; Dmel\\CG14513; Dmel_CG14513; Yemalpha; yG4.5; yT4.5; yem-alpha; yemalpha; yema", "gene_names_refseq": "CG11879; CG14513; Dmel\\CG14513; Yemalpha; yG4.5; yT4.5; yem-alpha; yemalpha; yema; yem", "protein_names_uniprotkb": "yemanuclein; Yemanuclein-alpha", "protein_names_refseq": "CG14513-PA; yem-PA; yem-alpha; yema nuclein alpha; yema-gene-4.5; yemalpha; yemanuclein alpha; yemanuclein, isoform A; yemanuclein-alpha", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14513)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1606021;16110336;17569856;17569867;18327897;21080953;25589440;26109356;26109357", "class_list": "", "function": "May play a key role in egg organization. May be a transcriptional regulator having a role in chromatin remodeling in concert with Hira, a histone chaperone. Involved in chromosome segregation by affecting kinetochores function in the first meiotic division., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWM5;Q9VAP4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0001940 male pronucleus;GO:0042585 germinal vesicle", "go_biological_process": "GO:0006325 chromatin organization;GO:0007143 female meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P25992-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KSC4-1", "uniprot_id": "MPC1_DROME", "mass": 12261.0, "length": 107, "protein_name": "Mitochondrial pyruvate carrier 1", "gene_name": "Mpc1", "organism": "Fruit fly", "refseq_name": "mitochondrial pyruvate carrier, isoform C", "refseq_ac": "NP_001262720", "gene_names_uniprotkb": "Mpc1; CG14290; Dmel\\CG14290; Dmel_CG14290; MPC1; MPC; dMPC1", "gene_names_refseq": "CG14290; Dmel\\CG14290; MPC1; MPC; Mpc1; dMPC1", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 1; MPC1", "protein_names_refseq": "CG14290-PC; Mpc1-PC; mitochondrial pyruvate carrier, isoform C; mitochondrial pyruvate carrier", "tax_id": 7227, "disease": "mitochondrial pyruvate carrier deficiency (Disease Ontology:DOID:0080363); intestinal cancer (Disease Ontology:DOID:10155); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG14290)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22628558;25589440;26109356;26109357", "class_list": "", "function": "Mediates the uptake of pyruvate into mitochondria., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:7770001 mitochondrial pyruvate carrier complex", "go_biological_process": "GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7KSC4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22807-1", "uniprot_id": "SLOU_DROME", "mass": 69955.0, "length": 659, "protein_name": "Homeobox protein slou", "gene_name": "slou", "organism": "Fruit fly", "refseq_name": "slouch, isoform A", "refseq_ac": "NP_476657", "gene_names_uniprotkb": "slou; CG6534; Dmel\\CG6534; Dmel_CG6534; NK-1; NK1; Nk1; S-59; S59; Slou; prd9; s59", "gene_names_refseq": "CG6534; Dmel\\CG6534; NK-1; NK1/S59; NK1; Nk1; S-59; S59/NK-1; S59; Slou; prd9; s59; slou/NK1; slou", "protein_names_uniprotkb": "Homeobox protein slou; Homeobox protein NK-1; Protein slouch; S59/2", "protein_names_refseq": "CG6534-PA; PRD gene 9; paired-like 9; slou-PA; slouch, isoform A; slouch", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6534)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;1980118;25589440;2573058;26109356;26109357", "class_list": "", "function": "May play a role in specifying the identity of particular somatic muscles and neurons of the CNS., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VD96", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0007521 muscle cell fate determination", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P22807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01603-1", "uniprot_id": "PERO_DROME", "mass": 76719.0, "length": 690, "protein_name": "Peroxidase", "gene_name": "Pxd", "organism": "Fruit fly", "refseq_name": "peroxidase, isoform B", "refseq_ac": "NP_001163633", "gene_names_uniprotkb": "Pxd; CG3477; DmPO; Dmel\\CG3477; Dmel_CG3477; Dpxd; HDC14047; HPX1; PO", "gene_names_refseq": "CG3477; DmPO; Dmel\\CG3477; Dpxd; HPX1; PO; Pxd", "protein_names_uniprotkb": "Peroxidase; 1.11.1.7; Chorion peroxidase; DmPO", "protein_names_refseq": "CG3477-PB; Pxd-PB; peroxidase, isoform B; peroxidase", "tax_id": 7227, "disease": "renovascular hypertension (Disease Ontology:DOID:1591); cystitis (Disease Ontology:DOID:1679); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (dme:Dmel_CG3477)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;14709175;1482687;15979004;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in the chorion hardening process, through protein cross-linking mediated by the formation of di- and tri-tyrosine bonds., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6IJW8;Q7KSF9", "ec_number_list": "1.11.1.-;1.11.1.7", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0140825 lactoperoxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0042600 egg chorion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042744 hydrogen peroxide catabolic process;GO:0007306 egg chorion assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q01603-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q94900-1", "uniprot_id": "GLUCL_DROME", "mass": 52334.0, "length": 456, "protein_name": "Glutamate-gated chloride channel", "gene_name": "GluClalpha", "organism": "Fruit fly", "refseq_name": "Glutamate-gated chloride channel subunit alpha, isoform L", "refseq_ac": "NP_001014641", "gene_names_uniprotkb": "GluClalpha; BcDNA:HL07853; CG7535; CT23049; Dm-GluCl; DmGluClalpha; DmGlu; Dmel\\CG7535; Dmel_CG7535; DrosGlu-Cl-alpha; DrosGluCl-alpha1; DrosGluCl-alpha; DrosGluCl; GLUCL; GluCalpha; GluClalpha1; GluCla; GluCl; dGluCl-alpha; glc; gluClalpha; glu", "gene_names_refseq": "BcDNA:HL07853; CG7535; CT23049; Dm-GluCl; DmGluClalpha; DmGlu; Dmel\\CG7535; DrosGlu-Cl-alpha; DrosGluCl-alpha1; DrosGluCl-alpha; DrosGluCl; GLUCL; GluCalpha; GluClalpha1; GluClalpha; GluCla; GluCl; dGluCl-alpha; glc; gluClalpha; glu", "protein_names_uniprotkb": "Glutamate-gated chloride channel; DrosGluCl", "protein_names_refseq": "CG7535-PL; GluClalpha-PL; Glutamate-gated chloride channel subunit alpha, isoform L; glutamate-gated chloride channel; indefinite", "tax_id": 7227, "disease": "hyperekplexia (Disease Ontology:DOID:0060695); hyperekplexia 1 (Disease Ontology:DOID:0060696); hyperekplexia 2 (Disease Ontology:DOID:0060697); syndromic X-linked intellectual disability Pilorge type (Disease Ontology:DOID:0070422)", "pathway": " (dme:Dmel_CG7535); (R-DME-112314)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;10966106;11095718;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;31535971;8702744;9886055", "class_list": "", "function": "Glutamate-gated chloride channel subunit (PubMed:11095718, PubMed:8702744). Together with Gamma-aminobutyric acid receptor Rdl, plays an important role in the visual response by regulating the activity of ON/OFF-selective neurons (PubMed:31535971)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O77295;Q0IGX3;Q0Q0M3;Q2PDQ5;Q59DV9;Q8IN68;Q9GQ52;Q9GQ53;Q9VDU5", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0008068 extracellularly glutamate-gated chloride channel activity;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q94900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08953-1", "uniprot_id": "TOLL_DROME", "mass": 124656.0, "length": 1097, "protein_name": "Protein toll", "gene_name": "Tl", "organism": "Fruit fly", "refseq_name": "toll, isoform B", "refseq_ac": "NP_524518", "gene_names_uniprotkb": "Tl; CG5490; CT17414; Dmel\\CG5490; Dmel_CG5490; EP(3)1051; EP1051; Fs(1)Tl; Fs(3)Tl; T1; TL; TOLL; TOL; Toll-1; Toll10B; Toll1; dToll1; dToll; mat(3)9; mel(3)10; mel(3)9; tl; toll-1; toll", "gene_names_refseq": "CG5490; CT17414; Dmel\\CG5490; EP(3)1051; EP1051; Fs(1)Tl; Fs(3)Tl; T1; TL; TOLL; TOL; Tl; Toll-1; Toll10B; Toll1; dToll1; dToll; mat(3)9; mel(3)10; mel(3)9; tl; toll-1; toll", "protein_names_uniprotkb": "Protein toll", "protein_names_refseq": "CG5490-PB; EP1051; TOLL; Tl-PB; Toll-1; protein toll precursor; toll receptor; toll, isoform B", "tax_id": 7227, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); sinusitis (Disease Ontology:DOID:0050127); alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); infective endocarditis (Disease Ontology:DOID:0060000); colitis (Disease Ontology:DOID:0060180); ileitis (Disease Ontology:DOID:0060189); atrial fibrillation (Disease Ontology:DOID:0060224); mastoiditis (Disease Ontology:DOID:0060322); respiratory allergy (Disease Ontology:DOID:0060496); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); herpes simplex virus keratitis (Disease Ontology:DOID:0080158); meningococcal meningitis (Disease Ontology:DOID:0080176); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); urinary tract infection (Disease Ontology:DOID:0080784); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hymenolepiasis (Disease Ontology:DOID:10074); dry eye syndrome (Disease Ontology:DOID:10140); dermatomyositis (Disease Ontology:DOID:10223); leprosy (Disease Ontology:DOID:1024); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); mastitis (Disease Ontology:DOID:10690); primary open angle glaucoma (Disease Ontology:DOID:1070); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); pulpitis (Disease Ontology:DOID:11121); anogenital venereal wart (Disease Ontology:DOID:11168); allergic conjunctivitis (Disease Ontology:DOID:11204); pyelonephritis (Disease Ontology:DOID:11400); sciatic neuropathy (Disease Ontology:DOID:11446); suppurative otitis media (Disease Ontology:DOID:11506); hepatorenal syndrome (Disease Ontology:DOID:11823); tympanosclerosis (Disease Ontology:DOID:1214); alveolar echinococcosis (Disease Ontology:DOID:12148); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); carotid stenosis (Disease Ontology:DOID:13001); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); low tension glaucoma (Disease Ontology:DOID:13544); aspergillosis (Disease Ontology:DOID:13564); exfoliation syndrome (Disease Ontology:DOID:13641); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); cystic fibrosis (Disease Ontology:DOID:1485); cystic echinococcosis (Disease Ontology:DOID:1495); alcohol use disorder (Disease Ontology:DOID:1574); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); skin papilloma (Disease Ontology:DOID:3178); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); tuberculosis (Disease Ontology:DOID:399); glucose metabolism disease (Disease Ontology:DOID:4194); macular degeneration (Disease Ontology:DOID:4448); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); keratitis (Disease Ontology:DOID:4677); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); eye disease (Disease Ontology:DOID:5614); uric acid nephrolithiasis (Disease Ontology:DOID:580); myocardial infarction (Disease Ontology:DOID:5844); primary immunodeficiency disease (Disease Ontology:DOID:612); acne (Disease Ontology:DOID:6543); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); arthritis (Disease Ontology:DOID:848); lung disease (Disease Ontology:DOID:850); gastroesophageal reflux disease (Disease Ontology:DOID:8534); collagen disease (Disease Ontology:DOID:854); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); cholesteatoma (Disease Ontology:DOID:869); bacterial pneumonia (Disease Ontology:DOID:874); seborrheic dermatitis (Disease Ontology:DOID:8741); molluscum contagiosum (Disease Ontology:DOID:8867); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); keratoconjunctivitis (Disease Ontology:DOID:9368); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG5490); (R-DME-209442); (R-DME-214842); (R-DME-214844); (R-DME-214862); (R-DME-214863); (R-DME-214869); (R-DME-214874)", "pathway_count": 8, "publication_count": 52, "publication_id_list": "10072384;10660298;10731132;10973475;11296245;11350927;11493599;11532919;11934858;12493753;12537568;12537569;12537572;12537573;12537574;12617819;12872120;12930753;14667416;14685264;15197269;15373972;15795223;16110336;16399077;16782008;16996061;17324925;17569856;17569867;18347020;1879347;19018662;20504957;2124970;22464169;23245851;23596340;24282309;2449285;24733933;25589440;26109356;26109357;3931919;8026333;8808632;8948598;9367441;9405646;9533958;9806920", "class_list": "", "function": "Receptor for the cleaved activated form of spz, spaetzle C-106 (PubMed:12872120). Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin (PubMed:10973475, PubMed:12872120, PubMed:8808632). Component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo (PubMed:3931919). Promotes heterophilic cellular adhesion (PubMed:2124970). Involved in synaptic targeting of motoneurons RP5 and V to muscle 12 (M12); functions as a repulsive cue inhibiting motoneuron synapse formation on muscle 13 (M13) to guide RP5 and V to the neighboring M12, where its expression is repressed by tey (PubMed:20504957). May also function in embryonic neuronal survival and the synaptic targeting of SNa motoneurons (PubMed:19018662)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 13, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 116, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "A4V3G7;A8WHK7;Q8MRF3;Q9VBB8", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0019955 cytokine binding;GO:0070976 TIR domain binding;GO:0046790 virion binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007507 heart development;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 6.6, "record_id": "P08953-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27415-1", "uniprot_id": "NLP_DROME", "mass": 16996.0, "length": 152, "protein_name": "Nucleoplasmin-like protein", "gene_name": "Nlp", "organism": "Fruit fly", "refseq_name": "nucleoplasmin, isoform B", "refseq_ac": "NP_001263094", "gene_names_uniprotkb": "Nlp; CG7917; CRP1; Crp1; Dmel\\CG7917; Dmel_CG7917; NLP; dCAF-4; dNLP-S; dNLP; nlp; p22", "gene_names_refseq": "CG7917; CRP1; Crp1; Dmel\\CG7917; NLP; Nlp; dCAF-4; dNLP-S; dNLP; nlp; p22", "protein_names_uniprotkb": "Nucleoplasmin-like protein; Chromatin decondensation protein 1; dNLP", "protein_names_refseq": "CG7917-PB; Nlp-PB; Nucleoplasmin-like; chromatin decondensation protein 1; nucleoplasmin, isoform B; nucleoplasmin-1", "tax_id": 7227, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dme:Dmel_CG7917); (R-DME-3899300); (R-DME-8869496); (R-DME-9833482)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12575937;16110336;17569856;17569867;23341925;25589440;26109356;26109357;8798787;9087911", "class_list": "", "function": "Binds to core histones and functions in the ATP-facilitated assembly of approximately regularly spaced nucleosomal arrays. May participate in parallel with other histone-binding proteins such as NAP-1., [UniProtKB]; Inactive for chromatin assembly. In vitro it appears to form a high molecular mass aggregate with the core histones., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24565;Q540W3;Q9VAC3", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0035041 sperm DNA decondensation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q27415-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JVE7-1", "uniprot_id": "SWET1_DROME", "mass": 25112.0, "length": 226, "protein_name": "Sugar transporter SWEET1", "gene_name": "slv", "organism": "Fruit fly", "refseq_name": "saliva, isoform B", "refseq_ac": "NP_001260797", "gene_names_uniprotkb": "slv; CG8717; Dmel\\CG8717; Dmel_CG8717", "gene_names_refseq": "CG8717; Dmel\\CG8717; slv", "protein_names_uniprotkb": "Sugar transporter SWEET1; Protein saliva", "protein_names_refseq": "CG8717-PB; saliva, isoform B; saliva; slv-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8717)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9739134", "class_list": "", "function": "Mediates both low-affinity uptake and efflux of sugar across the membrane., [UniProtKB, UniProtKB, UniProtKB]; Mediates sugar transport across membranes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O96879", "ec_number_list": "", "go_molecular_function": "GO:0051119 sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008643 carbohydrate transport;GO:0007431 salivary gland development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7JVE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q26454-1", "uniprot_id": "MCM4_DROME", "mass": 96610.0, "length": 866, "protein_name": "DNA replication licensing factor MCM4", "gene_name": "dpa", "organism": "Fruit fly", "refseq_name": "disc proliferation abnormal, isoform B", "refseq_ac": "NP_001286160", "gene_names_uniprotkb": "dpa; 43Ca; CG1616; DPA; DmMCM4; DmMcm4; DmeMCM4; Dmel\\CG1616; Dmel_CG1616; Dpa; MCM4_DROME; MCM4; Mcm4; l(2)43Ca; mcm4", "gene_names_refseq": "43Ca; CG1616; DPA; DmMCM4; DmMcm4; DmeMCM4; Dmel\\CG1616; Dpa; MCM4_DROME; MCM4; Mcm4; dpa; l(2)43Ca; mcm4", "protein_names_uniprotkb": "DNA replication licensing factor MCM4; 3.6.4.12; Protein disc proliferation abnormal", "protein_names_refseq": "CG1616-PB; disc proliferation abnormal, isoform B; disc proliferation abnormal; dpa-PB; drosophila proliferation abnormal", "tax_id": 7227, "disease": "immunodeficiency 54 (Disease Ontology:DOID:0111967)", "pathway": " (dme:Dmel_CG1616); (R-DME-176187); (R-DME-68867); (R-DME-68949); (R-DME-68962); (R-DME-69052)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16798881;17372656;17569856;17569867;18327897;20122406;25451925;25589440;26109356;26109357;7489728", "class_list": "", "function": "Acts as a component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. Essential role in mitotic DNA replication but not in endoreplication., [UniProtKB, PubMed, PubMed]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V4M5", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;2.7.11.22;2.7.11.23;2.7.7.7;3.1.11.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;2.7.7.-;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006260 DNA replication;GO:1902975 mitotic DNA replication initiation;GO:0007052 mitotic spindle organization;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q26454-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82712-1", "uniprot_id": "CCD1P_DROME", "mass": 60211.0, "length": 521, "protein_name": "Probable cytochrome P450 12d1 proximal, mitochondrial", "gene_name": "Cyp12d1-p", "organism": "Fruit fly", "refseq_name": "cytochrome P450 12d1 proximal, isoform B", "refseq_ac": "NP_001286304", "gene_names_uniprotkb": "Cyp12d1-p; 12D1; 12d1; CG18240; CG30489; CYP12A2; CYP12D1; CYP12d1-p; Cyp 12d1; Cyp12d1; Cyp12d; Dmel\\CG30489; Dmel_CG30489; cyp12d1-p; cyp12d1", "gene_names_refseq": "12D1; 12d1; CG18240; CG30489; CYP12A2; CYP12D1; CYP12d1-p; Cyp 12d1; Cyp12d1-p; Cyp12d1; Cyp12d; Dmel\\CG30489; cyp12d1-p; cyp12d1", "protein_names_uniprotkb": "Probable cytochrome P450 12d1 proximal, mitochondrial; 1.14.-.-; CYPXIID1", "protein_names_refseq": "CG30489-PB; Cyp12d1-p-PB; cytochrome P450 12d1 proximal, isoform B; cytochrome P450-12d1; cytochrome P450", "tax_id": 7227, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); infantile hypercalcemia 1 (Disease Ontology:DOID:0061136); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); gestational diabetes (Disease Ontology:DOID:11714); lung cancer (Disease Ontology:DOID:1324); extrahepatic cholestasis (Disease Ontology:DOID:13619); alcohol use disorder (Disease Ontology:DOID:1574); rectum cancer (Disease Ontology:DOID:1993); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); ovary adenocarcinoma (Disease Ontology:DOID:3713); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cerebrotendinous xanthomatosis (Disease Ontology:DOID:4810); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); lung small cell carcinoma (Disease Ontology:DOID:5409); ulcerative colitis (Disease Ontology:DOID:8577); Wilson disease (Disease Ontology:DOID:893); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG30489)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15663776;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IH46;Q8T4K3", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0017085 response to insecticide;GO:0046680 response to DDT", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P82712-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K2G1-1", "uniprot_id": "ADRM1_DROME", "mass": 42013.0, "length": 389, "protein_name": "Proteasomal ubiquitin receptor ADRM1 homolog", "gene_name": "Rpn13", "organism": "Fruit fly", "refseq_name": "regulatory particle non-ATPase 13, isoform D", "refseq_ac": "NP_001137662", "gene_names_uniprotkb": "Rpn13; CG13349; Dmel\\CG13349; Dmel_CG13349; GC13349; p42E; rpn13", "gene_names_refseq": "CG13349; Dmel\\CG13349; GC13349; Rpn13; p42E; rpn13", "protein_names_uniprotkb": "Proteasomal ubiquitin receptor ADRM1 homolog; Regulatory particle non-ATPase 13 protein; p42E", "protein_names_refseq": "CG13349-PD; Rpn13-PD; regulatory particle non-ATPase 13, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13349); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 48, "publication_count": 16, "publication_id_list": "10731132;11301252;12537568;12537569;12537572;12537573;12537574;14652013;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7YZG7;B7YZG8;Q86NT4", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding;GO:0061133 endopeptidase activator activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7K2G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29845-1", "uniprot_id": "HSP7E_DROME", "mass": 74066.0, "length": 686, "protein_name": "Heat shock 70 kDa protein cognate 5", "gene_name": "Hsc70-5", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 cognate 5, isoform B", "refseq_ac": "NP_001286414", "gene_names_uniprotkb": "Hsc70-5; CG8542; Dmel\\CG8542; Dmel_CG8542; HSC-70; HSC5; HSC70-5; HSC70; HSP70m1; Hsc-5; Hsc-70-5; Hsc5; Hsc70; Hsp-c5; dHSC70-5; dhsc70; hsc-70-5; hsc5; hsc70-5; hsc70; l(2)k04907; mtHsc70", "gene_names_refseq": "CG8542; Dmel\\CG8542; HSC-70; HSC5; HSC70-5; HSC70; HSP70m1; Hsc-5; Hsc-70-5; Hsc5; Hsc70-5; Hsc70; Hsp-c5; dHSC70-5; dhsc70; hsc-70-5; hsc5; hsc70-5; hsc70; l(2)k04907; mtHsc70", "protein_names_uniprotkb": "Heat shock 70 kDa protein cognate 5", "protein_names_refseq": "70 kDa heat shock protein, mitochondrial 1; CG8542-PB; Hsc70-5-PB; Hsp cognate 5; heat shock 70 kDa protein cognate 5; heat shock protein 70 cognate 5, isoform B; heat shock protein cognate 5; heat shock protein cognate 71; mortalin", "tax_id": 7227, "disease": "autosomal dominant sideroblastic anemia 4 (Disease Ontology:DOID:0060335); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); brain ischemia (Disease Ontology:DOID:2316); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dme:Dmel_CG8542); (R-DME-3371453); (R-DME-6799198); (R-DME-9837999); (R-DME-9865881)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8514184", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V6Z7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0007005 mitochondrion organization;GO:0010918 positive regulation of mitochondrial membrane potential;GO:0042026 protein refolding;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P29845-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q23997-1", "uniprot_id": "C5210_DROME", "mass": 50354.0, "length": 452, "protein_name": "Imaginal disk growth factor 6", "gene_name": "Idgf6", "organism": "Fruit fly", "refseq_name": "imaginal disc growth factor 6, isoform B", "refseq_ac": "NP_001286499", "gene_names_uniprotkb": "Idgf6; CG5210; Chit13; Chit; Cht13; DS47; DmDS47; DmIDGF6; Dmel\\CG5210; Dmel_CG5210; chit; ds47; idgf6", "gene_names_refseq": "CG5210; Chit13; Chit; Cht13; DS47; DmDS47; DmIDGF6; Dmel\\CG5210; Idgf6; chit; ds47; idgf6", "protein_names_uniprotkb": "Imaginal disk growth factor 6; Inactive chitinase-like protein", "protein_names_refseq": "CG5210-PB; Idgf6-PB; chitinase-like; imaginal disc growth factor 6, isoform B", "tax_id": 7227, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate carcinoma (Disease Ontology:DOID:10286); pre-eclampsia (Disease Ontology:DOID:10591); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); temporal arteritis (Disease Ontology:DOID:13375); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); chondrosarcoma (Disease Ontology:DOID:3371); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); neuromyelitis optica (Disease Ontology:DOID:8869); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG5210); (R-DME-189085); (R-DME-6798695)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18342251;20150340;25589440;26109356;26109357;7875581", "class_list": "", "function": "Chitinase-like chitin-binding protein that lacks chitinolytic activity (PubMed:18342251). Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RVC8;E1UIC7;E1UIC9;E1UID0;E1UID3;E1UID4;Q9V7S9", "ec_number_list": "", "go_molecular_function": "GO:0008061 chitin binding;GO:0008084 imaginal disc growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0042060 wound healing;GO:0006032 chitin catabolic process;GO:0035152 regulation of tube architecture, open tracheal system;GO:0007444 imaginal disc development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q23997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O96827-1", "uniprot_id": "EF1B_DROME", "mass": 24247.0, "length": 222, "protein_name": "Probable elongation factor 1-beta", "gene_name": "eEF1beta", "organism": "Fruit fly", "refseq_name": "eukaryotic translation elongation factor 1 beta, isoform C", "refseq_ac": "NP_001286506", "gene_names_uniprotkb": "eEF1beta; 154264_at; BcDNA.LD24492; BcDNA:LD24492; CG6341; Dmel\\CG6341; Dmel_CG6341; EG:EG0003.7; Ef1beta; Elf 1 beta", "gene_names_refseq": "154264_at; BcDNA.LD24492; BcDNA:LD24492; CG6341; Dmel\\CG6341; EG:EG0003.7; Ef1beta; Elf 1 beta; eEF1beta", "protein_names_uniprotkb": "Probable elongation factor 1-beta; EF-1-beta", "protein_names_refseq": "CG6341-PC; eEF1beta-PC; elongation facto 1 beta; elongation factor 1 beta; elongation factor 1beta; eukaryotic translation elongation factor 1 beta, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6341); (R-DME-156842)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;10731137;10731138;12537568;12537572;12537573;12537574;15952742;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005853 eukaryotic translation elongation factor 1 complex", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O96827-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27606-1", "uniprot_id": "CP4E2_DROME", "mass": 60693.0, "length": 526, "protein_name": "Cytochrome P450 4e2", "gene_name": "Cyp4e2", "organism": "Fruit fly", "refseq_name": "cytochrome P450 4e2, isoform B", "refseq_ac": "NP_001286196", "gene_names_uniprotkb": "Cyp4e2; 4e2; CG2060; CYP4E2; CyP4e2; Cyp4E2; Cyt-P450-4E2; Dmel\\CG2060; Dmel_CG2060; P-450; P450; cyp4e2", "gene_names_refseq": "4e2; CG2060; CYP4E2; CyP4e2; Cyp4E2; Cyp4e2; Cyt-P450-4E2; Dmel\\CG2060; P-450; P450; cyp4e2", "protein_names_uniprotkb": "Cytochrome P450 4e2; 1.14.-.-; CYPIVE2", "protein_names_refseq": "CG2060-PB; Cyp4e2-PB; cytochrome P450 4e2, isoform B; cytochrome P450-4e2; cytochrome P450", "tax_id": 7227, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664)", "pathway": " (dme:Dmel_CG2060); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8676871;8972915", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24130;Q24291;Q9V4T4", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q27606-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q26307-1", "uniprot_id": "ANA_DROME", "mass": 54015.0, "length": 474, "protein_name": "Protein anachronism", "gene_name": "ana", "organism": "Fruit fly", "refseq_name": "anachronism, isoform A", "refseq_ac": "NP_477038", "gene_names_uniprotkb": "ana; Ana; CG8084; Dmel\\CG8084; Dmel_CG8084; med", "gene_names_refseq": "Ana; CG8084; Dmel\\CG8084; ana; med", "protein_names_uniprotkb": "Protein anachronism", "protein_names_refseq": "CG8084-PA; ana-PA; anachronism, isoform A; anachronism; medullaless", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8084)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7916657", "class_list": "", "function": "Negatively regulates proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9V524", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0007406 negative regulation of neuroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q26307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JW12-1", "uniprot_id": "TMX2_DROME", "mass": 31323.0, "length": 271, "protein_name": "Thioredoxin-related transmembrane protein 2 homolog", "gene_name": "Dmel\\CG11007", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001286617", "gene_names_uniprotkb": "Dmel\\CG11007; CG11007; Dmel_CG11007", "gene_names_refseq": "CG11007; Dmel\\CG11007", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 2 homolog; Thioredoxin domain-containing protein 14 homolog", "protein_names_refseq": "CG11007-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11007)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7JW12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28465-1", "uniprot_id": "WNT2_DROME", "mass": 39763.0, "length": 352, "protein_name": "Protein Wnt-2", "gene_name": "Wnt2", "organism": "Fruit fly", "refseq_name": "Wnt oncogene analog 2, isoform A", "refseq_ac": "NP_476810", "gene_names_uniprotkb": "Wnt2; CG1916; D-wnt-2; DWnt-2; DWnt2; Dm DWnt2; Dm-2; Dmel\\CG1916; Dmel_CG1916; Dwnt-2; Dwnt2; Wnt-2; Wnt; dWnt2; wnt-2; wnt2", "gene_names_refseq": "CG1916; D-wnt-2; DWnt-2; DWnt2; Dm DWnt2; Dm-2; Dmel\\CG1916; Dwnt-2; Dwnt2; Wnt-2; Wnt2; Wnt; dWnt2; wnt-2; wnt2", "protein_names_uniprotkb": "Protein Wnt-2; dWnt-2", "protein_names_refseq": "CG1916-PA; Wnt oncogene analog 2, isoform A; Wnt2-PA", "tax_id": 7227, "disease": "Fuhrmann syndrome (Disease Ontology:DOID:0090067); Mullerian aplasia and hyperandrogenism (Disease Ontology:DOID:0111526); Schinzel type phocomelia (Disease Ontology:DOID:0112181); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); breast fibroadenoma (Disease Ontology:DOID:1618); endometrial carcinoma (Disease Ontology:DOID:2871); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (dme:Dmel_CG1916); (R-DME-3238698)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;11717401;12537568;12537572;12537573;12537574;1425336;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May function in gonadogenesis and limb development. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation., [UniProtKB, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q86PC8;Q9V584", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0007517 muscle organ development;GO:0030182 neuron differentiation;GO:0060070 canonical Wnt signaling pathway;GO:0048675 axon extension", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P28465-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25823-1", "uniprot_id": "TUD_DROME", "mass": 285267.0, "length": 2515, "protein_name": "Protein tudor", "gene_name": "tud", "organism": "Fruit fly", "refseq_name": "tudor, isoform A", "refseq_ac": "NP_476773", "gene_names_uniprotkb": "tud; CG9450; Dmel\\CG9450; Dmel_CG9450; R5_2R:17070527..17070890; TUD; Tudor; Tud; tu", "gene_names_refseq": "CG9450; Dmel\\CG9450; R5_2R:17070527..17070890; TUD; Tudor; Tud; tud; tu", "protein_names_uniprotkb": "Protein tudor", "protein_names_refseq": "CG9450-PA; TUDOR; tud-PA; tudor, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9450)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15800004;16110336;17428915;17569856;17569867;18327897;1936993;19959991;22303351;25589440;26109356;26109357;26212455;26295961;28945271", "class_list": "", "function": "May act via the Piwi-interacting RNA (piRNA) metabolic process mediated by aub and AGO3 Piwi proteins, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:19959991). Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation (PubMed:17428915). Not involved in repression of retroelements (PubMed:17428915)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9W2J8", "ec_number_list": "", "go_molecular_function": "GO:0140034 methylation-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030719 P granule organization;GO:0007281 germ cell development;GO:0048477 oogenesis;GO:1900370 positive regulation of post-transcriptional gene silencing by RNA;GO:0008298 intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P25823-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q11002-1", "uniprot_id": "CANA_DROME", "mass": 93963.0, "length": 828, "protein_name": "Calpain-A", "gene_name": "CalpA", "organism": "Fruit fly", "refseq_name": "Calpain-A, isoform C", "refseq_ac": "NP_001097378", "gene_names_uniprotkb": "CalpA; CG18152; CG7563; Dmel\\CG7563; Dmel_CG7563; EST C; calpA", "gene_names_refseq": "CG18152; CG7563; CalpA; Dmel\\CG7563; EST C; calpA", "protein_names_uniprotkb": "Calpain-A; 3.4.22.-; CANP A; Calcium-activated neutral proteinase A", "protein_names_refseq": "CG7563-PC; CalpA-PC; Calpain-A, isoform C; calpain A; calpain lacking calmodulin-like domain; calpainA; calpain", "tax_id": 7227, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); autosomal dominant limb-girdle muscular dystrophy (Disease Ontology:DOID:0110273); autosomal recessive limb-girdle muscular dystrophy type 2A (Disease Ontology:DOID:0110275); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); aortic atherosclerosis (Disease Ontology:DOID:10230); stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); epilepsy (Disease Ontology:DOID:1826); hereditary spastic paraplegia (Disease Ontology:DOID:2476); acute kidney failure (Disease Ontology:DOID:3021); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular dystrophy (Disease Ontology:DOID:9884); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG7563); (R-DME-6798695)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10446155;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7823949;7929201", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease. Involved in the organization of the actin-related cytoskeleton during embryogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V8U6;Q9V8U7", "ec_number_list": "2.4.1.186;5.4.2.7;5.4.2.-;3.2.1.31;1.1.1.42;2.4.2.1;2.7.11.24;2.7.1.40;4.1.2.13;2.7.4.6;3.6.5.-;1.11.1.6;5.3.1.9;2.7.1.11;1.1.1.205;3.4.22.-;3.6.4.12;3.6.4.6;1.16.3.1;2.3.2.5;3.4.24.-;2.3.2.27;2.7.1.1;5.2.1.8;3.4.19.-;1.11.1.24;5.6.1.5;5.4.2.11;5.4.2.4;3.2.1.23;3.6.1.5;3.6.4.13;3.3.2.6;3.5.4.5;2.7.11.22;2.7.11.23;4.2.1.24;5.4.2.2;3.4.-.-;2.4.1.25;3.2.1.33;2.7.1.-;3.5.4.6;2.3.2.26", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0015629 actin cytoskeleton;GO:0043025 neuronal cell body", "go_biological_process": "GO:0042335 cuticle development;GO:0006508 proteolysis;GO:0016322 neuron remodeling;GO:0007520 myoblast fusion;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q11002-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24573-1", "uniprot_id": "DRI_DROME", "mass": 97365.0, "length": 911, "protein_name": "Protein dead ringer", "gene_name": "retn", "organism": "Fruit fly", "refseq_name": "retained, isoform A", "refseq_ac": "NP_476864", "gene_names_uniprotkb": "retn; 2535; BcDNA:LD35748; CG5403; DRI; Dmel\\CG5403; Dmel_CG5403; Dri; EHMT; EY2-10; Retain; Retn; dri; l(2)02535", "gene_names_refseq": "2535; BcDNA:LD35748; CG5403; DRI; Dead Ringer/Retain; Dmel\\CG5403; Dri; EHMT; EY2-10; Retn; dri; l(2)02535; retn/dri; retn", "protein_names_uniprotkb": "Protein dead ringer; Protein retained", "protein_names_refseq": "CG5403-PA; dead Ringer/Retain; dead ringer; dead-ringer; retained, isoform A; retained; retn-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5403)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;11867548;12537568;12537569;12537572;12537573;12537574;12620977;15576402;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8622680", "class_list": "", "function": "Transcription factor which is a downstream target of gcm and repo. Directly or indirectly activates the transcription of locos and pros, which are essential for the development of some glial cells. Plays an essential role in defining the cell shape and migration characteristics of longitudinal glia that enable them to establish a normal axon scaffold., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSB0;Q9W1M0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0008049 male courtship behavior;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q24573-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22700-1", "uniprot_id": "ATC1_DROME", "mass": 111701.0, "length": 1020, "protein_name": "Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type", "gene_name": "SERCA", "organism": "Fruit fly", "refseq_name": "Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform A", "refseq_ac": "NP_476832", "gene_names_uniprotkb": "SERCA; 17136664; A4UZU0_DROME; ATC1_DROME; CA-P60A; CG3725; Ca-ATPase; Ca-P60A; Ca-P60; Ca-p; CaP60A; Ca[2+]ATPase; Ca[2+]P60A; Dmel\\CG3725; Dmel_CG3725; Kum; SERCA2; Serca2a; Serca; dSERCA; dserca; kum; l(2)SH0211; l(2)k08308ab; l(2)k09025; serca", "gene_names_refseq": "17136664; A4UZU0_DROME; ATC1_DROME; CA-P60A; CG3725; Ca-ATPase; Ca-P60A; Ca-P60; Ca-p; CaP60A; Ca[2+]ATPase; Ca[2+]P60A; Dmel\\CG3725; Kum; SERCA2; SERCA; Serca2a; Serca; dSERCA; dserca; kum; l(2)SH0211; l(2)k08308ab; l(2)k09025; serca", "protein_names_uniprotkb": "Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type; 7.2.2.10; Calcium ATPase at 60A; Calcium pump; Sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase", "protein_names_refseq": "CG3725-PA; Ca[2+] ATPase; SERCA-PA; Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform A; calcium ATPase at 60A; calcium ATPase; endoplasmic reticulum-specific calcium-transporting ATPase; kumbhakarna; lethal (2) SH0211; organellar-type Ca-ATPase; sarco endoplasmic reticulum calcium-ATPase; sarco/endoplasmic reticulum-type Ca-2+-ATPase; sarcoplasmic endoplasmic reticulum calcium ATPase type 2; serca", "tax_id": 7227, "disease": "acrokeratosis verruciformis (Disease Ontology:DOID:0050606); Brody myopathy (Disease Ontology:DOID:0050692); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); heart disease (Disease Ontology:DOID:114); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); hypothyroidism (Disease Ontology:DOID:1459); keratosis follicularis (Disease Ontology:DOID:2734); euthyroid sick syndrome (Disease Ontology:DOID:2856); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG3725); (R-DME-418359); (R-DME-5578775); (R-DME-936837)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;2148477;23970561;2557235;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB]; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZU0;Q2MGN2;Q95TX1;Q9W1G2;Q9W1G3", "ec_number_list": "7.2.2.10;2.7.11.17", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0030322 stabilization of membrane potential;GO:0007274 neuromuscular synaptic transmission;GO:0048863 stem cell differentiation;GO:0006874 intracellular calcium ion homeostasis;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P22700-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40656-1", "uniprot_id": "SOX14_DROME", "mass": 72742.0, "length": 669, "protein_name": "Putative transcription factor SOX-14", "gene_name": "Sox14", "organism": "Fruit fly", "refseq_name": "Sox box protein 14, isoform C", "refseq_ac": "NP_001286801", "gene_names_uniprotkb": "Sox14; CG17263; CG3090; DSox-14; DSox14; DSox60B; Dmel\\CG3090; Dmel_CG3090; Dsox-14; SOX14; SOX60B; SOXC; Sox-14; sox14", "gene_names_refseq": "CG17263; CG3090; DSox-14; DSox14; DSox60B; Dmel\\CG3090; Dsox-14; SOX14; SOX60B; SOXC; Sox-14; Sox14; sox14", "protein_names_uniprotkb": "Putative transcription factor SOX-14", "protein_names_refseq": "CG3090-PC; Sox box protein 14, isoform C; Sox14-PC; sox box protein 14", "tax_id": 7227, "disease": "Coffin-Siris syndrome 9 (Disease Ontology:DOID:0070057); Coffin-Siris syndrome 10 (Disease Ontology:DOID:0112371); urinary bladder cancer (Disease Ontology:DOID:11054); Coffin-Siris syndrome (Disease Ontology:DOID:1925); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258)", "pathway": " (dme:Dmel_CG3090); (R-DME-3769402)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;1614875;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2MGM9;Q9U1H4;Q9W1E2;Q9W1E3", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016322 neuron remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P40656-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02637-1", "uniprot_id": "CEBP_DROME", "mass": 49420.0, "length": 449, "protein_name": "CCAAT/enhancer-binding protein", "gene_name": "slbo", "organism": "Fruit fly", "refseq_name": "slow border cells, isoform B", "refseq_ac": "NP_001286836", "gene_names_uniprotkb": "slbo; CG4354; DM8; Dmel\\CG4354; Dmel_CG4354; EBP; SLBO; Slbo; fs(2)7; fs(2)8; fs(2)ry7; fs(2)ry8; slobo", "gene_names_refseq": "C/EBP; CG4354; DC/EBP; DM8; Dm-c/EBP; DmC/EBP; Dmel\\CG4354; SLBO; Slbo; fs(2)7; fs(2)8; fs(2)ry7; fs(2)ry8; slbo; slobo", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein; C/EBP; Slow border cell protein", "protein_names_refseq": "CCAAT/enhancer binding protein; CG4354-PB; slbo-PB; slow border cells, isoform B; slow border cells", "tax_id": 7227, "disease": "immunodeficiency 108 (Disease Ontology:DOID:0061077); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); transient cerebral ischemia (Disease Ontology:DOID:224); osteochondrodysplasia (Disease Ontology:DOID:2256); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); acute myeloid leukemia (Disease Ontology:DOID:9119); viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (dme:Dmel_CG4354)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;10949024;12537568;12537572;12537573;12537574;1394432;1459454;16110336;17569856;17569867;23305818;25589440;26109356;26109357", "class_list": "", "function": "Required for the expression of gene products mediating border cell migration (PubMed:10949024, PubMed:1459454, PubMed:23305818). Among the DNA sequences that this protein binds with high affinity is a conserved site within the promoter of its gene (PubMed:1459454)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W183", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007298 border follicle cell migration;GO:1903688 positive regulation of border follicle cell migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q02637-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10379-1", "uniprot_id": "UZIP_DROME", "mass": 54308.0, "length": 488, "protein_name": "Protein unzipped", "gene_name": "uzip", "organism": "Fruit fly", "refseq_name": "unzipped, isoform B", "refseq_ac": "NP_001286875", "gene_names_uniprotkb": "uzip; CG3533; Dmel\\CG3533; Dmel_CG3533; Uzip; nzip; zip", "gene_names_refseq": "CG3533; Dmel\\CG3533; Uzip; nzip; uzip; zip", "protein_names_uniprotkb": "Protein unzipped; Protein zipper", "protein_names_refseq": "CG3533-PB; not-zipper; unzipped, isoform B; unzipped; uzip-PB; zipper", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3533)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17893096;19349973;25589440;26109356;26109357;3402433", "class_list": "", "function": "Required for normal axon patterning during neurogenesis., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q960B4;Q9W0W7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007413 axonal fasciculation;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P10379-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36872-1", "uniprot_id": "2ABA_DROME", "mass": 56967.0, "length": 499, "protein_name": "Protein phosphatase PP2A 55 kDa regulatory subunit", "gene_name": "tws", "organism": "Fruit fly", "refseq_name": "twins, isoform I", "refseq_ac": "NP_001287269", "gene_names_uniprotkb": "tws; 06; 2414; CG6235; DPR55; Dmel\\CG6235; Dmel_CG6235; PP2A-B55; PP2A[B]; PP2A; PP2a; PR55; Pp2A-85F; TWS; Twins; Tws; aar; dPP2A-B55; dPP2A-Balpha; dPP2A; dPR55; l(3)01436; l(3)02414; l(3)S022205b; l(3)S022361; l(3)S022440; l(3)S023013; l(3)S023141a; l(3)S023206; l(3)S023309; l(3)S023938; l(3)S024455; l(3)S024834a; l(3)S024838; l(3)S025806; l(3)S025832; l(3)S025913; l(3)S026226; l(3)S026326; l(3)S027127; l(3)S027313; l(3)S028707; l(3)S029110; l(3)S029403; l(3)S029701a; l(3)S031006; l(3)S032303; l(3)S032708c; l(3)S033903; l(3)S035505b; l(3)S042629; l(3)S042630; l(3)S043008b; l(3)S043029; l(3)S045519; l(3)S046918; l(3)S048006; l(3)S048013; l(3)S048507; l(3)S049902; l(3)S052810; l(3)S053011; l(3)S060203; l(3)S060804; l(3)S061805; l(3)S061915; l(3)S063110; l(3)S066017; l(3)S066813; l(3)S067109b; l(3)S067915; l(3)S069206a; l(3)S075110; l(3)S075515b; l(3)S075902b; l(3)S076415; l(3)S080409; l(3)S088513; l(3)S091905; l(3)S101413b; l(3)S105605; l(3)S110008a; l(3)S110815; l(3)S111515; l(3)S119908; l(3)S132907; l(3)S134601a; l(3)S141309; l(3)S146606; l(3)j11C8; l(3)s1801; tw; v158", "gene_names_refseq": "1466/06; 2414; B/PR55; CG6235; DPR55; Dmel\\CG6235; PP2A-B55; PP2A[B]; PP2A; PP2a; PR55; Pp2A-85F; TWS; Twins; Tws; aar; dPP2A-B55; dPP2A-Balpha; dPP2A; dPR55; l(3)01436; l(3)02414; l(3)S022205b; l(3)S022361; l(3)S022440; l(3)S023013; l(3)S023141a; l(3)S023206; l(3)S023309; l(3)S023938; l(3)S024455; l(3)S024834a; l(3)S024838; l(3)S025806; l(3)S025832; l(3)S025913; l(3)S026226; l(3)S026326; l(3)S027127; l(3)S027313; l(3)S028707; l(3)S029110; l(3)S029403; l(3)S029701a; l(3)S031006; l(3)S032303; l(3)S032708c; l(3)S033903; l(3)S035505b; l(3)S042629; l(3)S042630; l(3)S043008b; l(3)S043029; l(3)S045519; l(3)S046918; l(3)S048006; l(3)S048013; l(3)S048507; l(3)S049902; l(3)S052810; l(3)S053011; l(3)S060203; l(3)S060804; l(3)S061805; l(3)S061915; l(3)S063110; l(3)S066017; l(3)S066813; l(3)S067109b; l(3)S067915; l(3)S069206a; l(3)S075110; l(3)S075515b; l(3)S075902b; l(3)S076415; l(3)S080409; l(3)S088513; l(3)S091905; l(3)S101413b; l(3)S105605; l(3)S110008a; l(3)S110815; l(3)S111515; l(3)S119908; l(3)S132907; l(3)S134601a; l(3)S141309; l(3)S146606; l(3)j11C8; l(3)s1801; tws/aar; tws; tw; v158", "protein_names_uniprotkb": "Protein phosphatase PP2A 55 kDa regulatory subunit; PR55; Protein phosphatase PP2A regulatory subunit B; Protein twins", "protein_names_refseq": "CG6235-PI; PP2A regulatory subunit twins; PP2A-B; abnormal anaphase resolution; phosphoprotein phosphatase 2A 55 kDa; protein phosphatase 2A at 85F; protein phosphatase 2A; protein phosphatase type 2A; regulatory B subunit of type 2A protein phosphatase; twins, isoform I; twins; tws-PI", "tax_id": 7227, "disease": "spinocerebellar ataxia 12 (Disease Ontology:DOID:0050962); Alzheimer's disease (Disease Ontology:DOID:10652); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); breast cancer (Disease Ontology:DOID:1612); systemic lupus erythematosus (Disease Ontology:DOID:9074); brain disease (Disease Ontology:DOID:936)", "pathway": " (dme:Dmel_CG6235); (R-DME-209155); (R-DME-209190); (R-DME-209214); (R-DME-209360); (R-DME-209396); (R-DME-209413); (R-DME-209440); (R-DME-209461); (R-DME-2995383); (R-DME-432553); (R-DME-432620); (R-DME-69231); (R-DME-69273); (R-DME-975957); (R-DME-9860927)", "pathway_count": 16, "publication_count": 79, "publication_id_list": "10073940;10102270;10196136;10409506;10421629;10457025;10458606;10477300;10557210;10731132;10838083;10846164;11336703;11430804;11440719;11912487;11927557;11955435;11955436;12000790;12122057;12231619;12432393;12442174;12447397;12537568;12537569;12537572;12537573;12537574;12563262;12636921;12663920;12781135;12944510;14636582;14731402;14759367;14966281;14980226;15300262;15459103;15563523;15592457;15598741;15616566;15875013;16041759;16110336;16299518;16319317;16326393;16386907;16410523;16630821;17077139;17418796;17569856;17569867;17575052;17925225;18593878;18815259;25589440;26109356;26109357;7481773;8382567;8383623;8596938;8600384;8898207;8906787;8906794;8938123;8990193;9215627;9482888;9674431", "class_list": "", "function": "Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2M9;A4V2N0;Q9VH21;Q9VH22", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000278 mitotic cell cycle;GO:0050821 protein stabilization;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0030071 regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 8.0, "record_id": "P36872-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SY61-1", "uniprot_id": "OB56D_DROME", "mass": 14119.0, "length": 131, "protein_name": "General odorant-binding protein 56d", "gene_name": "Obp56d", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 56d, isoform B", "refseq_ac": "NP_001286619", "gene_names_uniprotkb": "Obp56d; 56d; BEST:GH09027; BcDNA:RE22207; CG11218; CT31326; DmelObp56d; Dmel\\CG11218; Dmel_CG11218; OBP56d; RH69634p; obp56d", "gene_names_refseq": "56d; BEST:GH09027; BcDNA:RE22207; CG11218; CT31326; DmelObp56d; Dmel\\CG11218; OBP56d; Obp56d; RH69634p; obp56d", "protein_names_uniprotkb": "General odorant-binding protein 56d", "protein_names_refseq": "CG11218-PB; Obp56d-PB; Odorant-binding protein 56d, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11218)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;11729153;12505997;12537568;12537569;12537572;12537573;12537574;12727233;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V8Y4", "ec_number_list": "", "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8SY61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05319-1", "uniprot_id": "STUB_DROME", "mass": 85144.0, "length": 787, "protein_name": "Serine proteinase stubble", "gene_name": "Sb", "organism": "Fruit fly", "refseq_name": "stubble, isoform B", "refseq_ac": "NP_001287355", "gene_names_uniprotkb": "Sb; CG4316; Dmel\\CG4316; Dmel_CG4316; SP56; Sb-sbd; c-SP56; cSP56; sbd; st-sb", "gene_names_refseq": "CG4316; Dmel\\CG4316; SP56; Sb-sbd; Sb; c-SP56; cSP56; sbd; st-sb", "protein_names_uniprotkb": "Serine proteinase stubble; 3.4.21.-; Protein stubble-stubbloid", "protein_names_refseq": "CG4316-PB; Sb-PB; Stubble-stubbloid; stubble, isoform B; stubbloid", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); ductal carcinoma in situ (Disease Ontology:DOID:0060074); autosomal recessive congenital ichthyosis 11 (Disease Ontology:DOID:0060720); enterokinase deficiency (Disease Ontology:DOID:0111667); granulosa cell tumor (Disease Ontology:DOID:2999); dysgerminoma (Disease Ontology:DOID:4441); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dme:Dmel_CG4316); (R-DME-1474228)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7685111", "class_list": "", "function": "Hormone dependent protease required for epithelial morphogenesis, including the formation of bristles, legs, and wings. Has a dual function, detaches imaginal disk cells from extracellular matrices through its extracellular proteolytic domain and transmits an outside-to-inside signal to its intracellular domain to modify the cytoskeleton during morphogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRH5;Q9VEY6", "ec_number_list": "3.4.21.-;3.4.24.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0051017 actin filament bundle assembly;GO:0007010 cytoskeleton organization;GO:0035220 wing disc development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q05319-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08175-1", "uniprot_id": "MS87F_DROME", "mass": 5233.0, "length": 56, "protein_name": "Male-specific sperm protein Mst87F", "gene_name": "Mst87F", "organism": "Fruit fly", "refseq_name": "Male-specific RNA 87F, isoform B", "refseq_ac": "NP_001287317", "gene_names_uniprotkb": "Mst87F; BEST:GH23081; CG17956; Dmel\\CG17956; Dmel_CG17956; MST87F; Mst; bs35f12.y1; mst(3)87F; mst(3)gl-9; mst(3)gl9; mst-9; mst87F", "gene_names_refseq": "BEST:GH23081; CG17956; Dmel\\CG17956; MST87F; Mst87F; Mst; bs35f12.y1; mst(3)87F; mst(3)gl-9; mst(3)gl9; mst-9; mst87F", "protein_names_uniprotkb": "Male-specific sperm protein Mst87F", "protein_names_refseq": "CG17956-PB; Male-specific RNA 87F, isoform B; Mst87F-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17956)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16951084;17569856;17569867;19126864;25589440;26109356;26109357;2835228", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0ANE9;A0ANF2;A0ANF8;B6IDT2;C0MHZ0;C0MHZ1;Q9VFQ6", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P08175-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24251-1", "uniprot_id": "ATP5H_DROME", "mass": 20201.0, "length": 178, "protein_name": "ATP synthase subunit d, mitochondrial", "gene_name": "ATPsynD", "organism": "Fruit fly", "refseq_name": "ATP synthase, subunit D, isoform C", "refseq_ac": "NP_001287401", "gene_names_uniprotkb": "ATPsynD; ATP syn-d; ATPQ; ATPsyn-D; ATPsyn-delta; ATPsyn-d; CG6030; Dmel\\CG6030; Dmel_CG6030", "gene_names_refseq": "ATP syn-d; ATPQ; ATPsyn-D; ATPsyn-delta; ATPsyn-d; ATPsynD; CG6030; Dmel\\CG6030", "protein_names_uniprotkb": "ATP synthase subunit d, mitochondrial; ATPase subunit d", "protein_names_refseq": "ATP synthase D chain; ATP synthase chain D; ATP synthase subunits d; ATP synthase, subunit D, isoform C; ATP synthase, subunit d; ATP synthase,d; ATPase synthase, subunit d; ATPsyn-d; ATPsynD-PC; CG6030-PC; F0/F1 ATP synthase D", "tax_id": 7227, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dme:Dmel_CG6030); (R-DME-163210); (R-DME-8949613); (R-DME-9837999)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10071211;10731132;12537568;12537569;12537572;12537573;12537574;16110336;16120803;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V344;Q2XYL2;Q8MTU3;Q9VE03", "ec_number_list": "", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0051881 regulation of mitochondrial membrane potential;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0032007 negative regulation of TOR signaling;GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24251-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q23982-1", "uniprot_id": "PEB2_DROME", "mass": 7187.0, "length": 66, "protein_name": "Ejaculatory bulb-specific protein 2", "gene_name": "EbpII", "organism": "Fruit fly", "refseq_name": "ejaculatory bulb protein II, isoform B", "refseq_ac": "NP_001286879", "gene_names_uniprotkb": "EbpII; CG2665; Dmel\\CG2665; Dmel_CG2665; FBgn0011694; PEB2; PEBII; PEBmeII; PEB; PebII", "gene_names_refseq": "CG2665; Dmel\\CG2665; EbpII; FBgn0011694; PEB2; PEBII; PEBmeII; PEB; PebII", "protein_names_uniprotkb": "Ejaculatory bulb-specific protein 2; Ejaculatory bulb-specific protein II; PEB-meII", "protein_names_refseq": "CG2665-PB; EbpII-PB; ejaculatory bulb protein II, isoform B; protein ejaculatory bulb II", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2665)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7619487", "class_list": "", "function": "Protein component of the posterior mating plug., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3M3;Q4V3M4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0042628 mating plug formation;GO:0045434 negative regulation of female receptivity, post-mating", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q23982-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29775-1", "uniprot_id": "ETS4_DROME", "mass": 57713.0, "length": 518, "protein_name": "DNA-binding protein D-ETS-4", "gene_name": "Ets98B", "organism": "Fruit fly", "refseq_name": "Ets at 98B, isoform A", "refseq_ac": "NP_524535", "gene_names_uniprotkb": "Ets98B; CG5583; D-Ets-4; D-ets-4; D-ets4; Dmel\\CG5583; Dmel_CG5583; ETS-4; ETS4; Ets4; Ets; ets98B", "gene_names_refseq": "CG5583; D-Ets-4; D-ets-4; D-ets4; Dmel\\CG5583; ETS4; Ets4; Ets98B; Ets; ets98B", "protein_names_uniprotkb": "DNA-binding protein D-ETS-4", "protein_names_refseq": "CG5583-PA; Ets at 98B, isoform A; Ets98B-PA", "tax_id": 7227, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG5583)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1577186;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May have a role in germline development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VB00", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P29775-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32028-1", "uniprot_id": "FD4_DROME", "mass": 41723.0, "length": 372, "protein_name": "Fork head domain-containing protein FD4", "gene_name": "fd96Ca", "organism": "Fruit fly", "refseq_name": "forkhead domain 96Ca, isoform B", "refseq_ac": "NP_001287516", "gene_names_uniprotkb": "fd96Ca; CG11921; Dm-FoxB1; Dmel\\CG11921; Dmel_CG11921; Dmfd4; FD4; FoxB; fd4", "gene_names_refseq": "CG11921; Dm-FoxB1; Dmel\\CG11921; Dmfd4; FD4; FoxB; fd4; fd96Ca", "protein_names_uniprotkb": "Fork head domain-containing protein FD4", "protein_names_refseq": "CG11921-PB; fd96Ca-PB; forkhead domain 96Ca, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11921)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1356269;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in development during embryogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q058R6;Q9VBY1", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32028-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8INB9-1", "uniprot_id": "AKT1_DROME", "mass": 68485.0, "length": 611, "protein_name": "RAC serine/threonine-protein kinase", "gene_name": "Akt", "organism": "Fruit fly", "refseq_name": "Akt kinase, isoform D", "refseq_ac": "NP_001287353", "gene_names_uniprotkb": "Akt; AKT-1; AKT1; AKT; Akt-1; Akt1; Akt; CG4006; D-Akt; DAKT1; DAKT; DAkt1; DAkt; DPKB; DRAC-PK66; DRAC-PK85; DRAC-PK; Dakt1; Dakt; Dkat1; Dmel\\CG4006; Dmel_CG4006; Dpkb; P-AKT; P-Akt; PBB; PKB; RAC; RacPK; akt1; akt; dAKT1; dAKT; dAkt1; dAkt; dPKB; dakt1; dakt; l(3)04226; l(3)89Bq; p-Akt; pAkt", "gene_names_refseq": "AKT-1; AKT/PKB; AKT1; AKT; Akt-1; Akt/PKB; Akt1; Akt; CG4006; D-Akt; DAKT1/PKB; DAKT1; DAKT; DAkt1; DAkt; DPKB; DRAC-PK66; DRAC-PK85; DRAC-PK; Dakt1; Dakt; Dkat1; Dmel\\CG4006; Dpkb; P-AKT; P-Akt; PBB; PKB/AKT; PKB/Akt; PKB/dAKT; PKB; RAC; RacPK; akt1; akt; dAKT/dPKB; dAKT1; dAKT; dAkt/PKB; dAkt1; dAkt; dPKB; dakt1; dakt; l(3)04226; l(3)89Bq; p-Akt; pAkt", "protein_names_uniprotkb": "RAC serine/threonine-protein kinase; 2.7.11.1; DAkt; DRAC-PK; Dakt1; PKB; Protein kinase B", "protein_names_refseq": "Akt kinase, isoform D; Akt-PD; Akt1; CG4006-PD; RAC serine/threonine protein kinase; dAkt kinase; protein kinase B; related to PKA to PKC protein kinases; related to the A and C kinases", "tax_id": 7227, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Cowden syndrome 6 (Disease Ontology:DOID:0081002); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypoinsulinemic hypoglycemia with hemihypertrophy (Disease Ontology:DOID:0112263); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); esophageal carcinoma (Disease Ontology:DOID:1107); polycystic ovary syndrome (Disease Ontology:DOID:11612); alcoholic hepatitis (Disease Ontology:DOID:12351); vulva cancer (Disease Ontology:DOID:1245); Proteus syndrome (Disease Ontology:DOID:13482); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); opiate dependence (Disease Ontology:DOID:2559); pulmonary tuberculosis (Disease Ontology:DOID:2957); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); bipolar disorder (Disease Ontology:DOID:3312); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); esophageal cancer (Disease Ontology:DOID:5041); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); paraplegia (Disease Ontology:DOID:607); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (dme:Dmel_CG4006); (R-DME-110478); (R-DME-110523); (R-DME-1257604); (R-DME-1358803); (R-DME-1474151); (R-DME-165158); (R-DME-165159); (R-DME-165181); (R-DME-198323); (R-DME-198693); (R-DME-199418); (R-DME-203615); (R-DME-211163); (R-DME-354192); (R-DME-3769402); (R-DME-389357); (R-DME-389513); (R-DME-392451); (R-DME-450385); (R-DME-450604); (R-DME-5218920); (R-DME-5628897); (R-DME-6804758); (R-DME-6804759); (R-DME-6811558); (R-DME-69202); (R-DME-69656); (R-DME-8876198); (R-DME-8948751); (R-DME-9009391); (R-DME-9604323); (R-DME-9607240); (R-DME-9614399); (R-DME-9634638); (R-DME-9755511); (R-DME-9841251); (R-DME-9856530); (R-DME-9856649)", "pathway_count": 39, "publication_count": 44, "publication_id_list": "10455177;10587646;10731132;10801879;10962553;11250149;11344272;11389445;11740943;11752451;11872800;12172554;12537568;12537569;12537572;12537573;12537574;12771962;12893776;14525946;15466161;15712201;15718470;15808505;16110336;17569856;17569867;18268102;18327897;22493059;24603715;24786828;25329475;25589440;26109356;26109357;29025897;7628438;7876156;8302573;8978685;9169420;9368760;9601646", "class_list": "", "function": "Serine/threonine kinase involved in various developmental processes (PubMed:10587646, PubMed:10962553, PubMed:11740943, PubMed:11872800, PubMed:12172554, PubMed:12893776, PubMed:14525946, PubMed:15466161, PubMed:15712201, PubMed:9601646). During early embryogenesis, acts as a survival protein (PubMed:10962553, PubMed:9601646). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination (PubMed:11740943). Also regulates tracheal cell migration (PubMed:11740943, PubMed:14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed:10587646, PubMed:10962553, PubMed:11752451, PubMed:12893776, PubMed:24603715, PubMed:25329475, PubMed:29025897). Controls follicle cell size during oogenesis (PubMed:15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex (PubMed:12172554, PubMed:15466161). Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth (PubMed:10962553)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0KI65;Q24293;Q24469;Q24470;Q7JN11;Q8T9A5;Q9VEY7", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;5.6.1.8;2.7.11.11;2.7.11.23;3.1.3.16;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;1.14.13.39;3.4.22.61;2.7.10.2;3.4.19.12;2.7.11.10;3.6.5.-;2.3.2.27;2.7.11.-;2.7.11.39;2.3.1.48", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0043025 neuronal cell body", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0048680 positive regulation of axon regeneration;GO:0006979 response to oxidative stress;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q8INB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48601-1", "uniprot_id": "PRS4_DROME", "mass": 49324.0, "length": 439, "protein_name": "26S proteasome regulatory subunit 4", "gene_name": "Rpt2", "organism": "Fruit fly", "refseq_name": "regulatory particle triple-A ATPase 2, isoform B", "refseq_ac": "NP_001287493", "gene_names_uniprotkb": "Rpt2; 5289; CG5289; Dm-S4-1; DmP26S4; Dm_Rpt2; Dmel\\CG5289; Dmel_CG5289; P26s4; PSMC1; Pros26.4; S4; dRpt2; p56; pros26.4; rpt2", "gene_names_refseq": "5289; CG5289; Dm-S4-1; DmP26S4; Dm_Rpt2; Dmel\\CG5289; P26s4; PSMC1; Pros26.4; Rpt2; S4; dRpt2; p56; pros26.4; rpt2", "protein_names_uniprotkb": "26S proteasome regulatory subunit 4; P26s4", "protein_names_refseq": "26S proteasome subunit 4 ATPase; CG5289-PB; Rpt2-PB; proteasome 26S subunit 4 ATPase; proteasome 26S subunit subunit 4 ATPase; regulatory particle triple-A ATPase 2, isoform B", "tax_id": 7227, "disease": "neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (Disease Ontology:DOID:0081324); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dme:Dmel_CG5289); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-532668); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 57, "publication_count": 46, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537568;12537569;12537572;12537573;12537574;12973300;15178801;15258584;15331761;16110336;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17569856;17569867;17925225;18519643;18593878;19185492;23622245;25589440;26109356;26109357;7705656;8808288;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VCG1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005838 proteasome regulatory particle;GO:0005634 nucleus", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P48601-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27591-1", "uniprot_id": "ITBN_DROME", "mass": 90842.0, "length": 799, "protein_name": "Integrin beta-nu", "gene_name": "Itgbn", "organism": "Fruit fly", "refseq_name": "integrin betanu subunit, isoform B", "refseq_ac": "NP_001303333", "gene_names_uniprotkb": "Itgbn; Beta[[nu]]; CG1762; CT5192; Dmel\\CG1762; Dmel_CG1762; Fly betanu; ITGbeta PSv; Integrinbetanu; Itgbetanu; Itgbetav; beta integrin; beta-Integrin; beta-nu; betaInt nu; betaInt-&ngr; betaInt-nu; betaInt[nu]; betaInt; betaV-integrin; beta[[v]]; beta[nu]-integrin; beta[v]integrin; betagr:-nu; betanu; betav; intbetanu; integrin betaPs", "gene_names_refseq": "-nu; Beta[[nu]]; CG1762; CT5192; Dmel\\CG1762; Fly betanu; ITGbeta PSv; Integrinbetanu; Itgbetanu; Itgbetav; Itgbn; beta integrin; beta-Integrin; beta-nu; betaInt nu; betaInt-&ngr; betaInt-nu; betaInt[nu]; betaInt; betaV-integrin; beta[[v]]; beta[nu]-integrin; beta[v]integrin; betagr; betanu; betav; intbetanu; integrin betaPs", "protein_names_uniprotkb": "Integrin beta-nu", "protein_names_refseq": "CG1762-PB; Itgbn-PB; beta-Integrin-nu; beta[[nu]]Integrin; beta[nu] integrin; beta[v]integrin; betanu integrin; betanuintegrin; betav integrin; integrin BetaPS; integrin beta neu; integrin beta v; integrin betanu subunit, isoform B; integrin betanu subunit; integrin bn; integrinbetanu", "tax_id": 7227, "disease": "junctional epidermolysis bullosa with pyloric atresia (Disease Ontology:DOID:0060733); junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); junctional epidermolysis bullosa (Disease Ontology:DOID:3209)", "pathway": " (dme:Dmel_CG1762); (R-DME-114608); (R-DME-1236973); (R-DME-2129379); (R-DME-216083); (R-DME-2173789); (R-DME-3000170); (R-DME-354192); (R-DME-445144); (R-DME-445355); (R-DME-446107); (R-DME-6798695)", "pathway_count": 12, "publication_count": 18, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15469969;16110336;17569856;17569867;18925939;21592968;22547074;23054837;23426364;25589440;26109356;26109357;8076521", "class_list": "", "function": "Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Not required for the production of antimicrobial peptides during S.aureus. Upon activation by LanA, integrin alpha-PS3/beta-nu activates Fak in presynapsis to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with LanA, glutamate receptor-modulated NMJ growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A9UN88;Q9VIG7", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016020 membrane;GO:0008305 integrin complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0046716 muscle cell cellular homeostasis;GO:0006909 phagocytosis;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q27591-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P91621-1", "uniprot_id": "SIF1_DROME", "mass": 231130.0, "length": 2072, "protein_name": "Protein still life, isoform SIF type 1", "gene_name": "sif", "organism": "Fruit fly", "refseq_name": "still life, isoform I", "refseq_ac": "NP_001097519", "gene_names_uniprotkb": "sif; CG32414; CG34418; CG5256; CG5406; Dm_3L:26493; Dmel\\CG34418; Dmel_CG34418; RhoGEF; SIF; Sif; Stilllife; lincRNA.447; slf", "gene_names_refseq": "CG32414; CG34418; CG5256; CG5406; Dm_3L:26493; Dmel\\CG34418; RhoGEF; SIF; Sif; Stilllife; lincRNA.447; sif; slf", "protein_names_uniprotkb": "Protein still life, isoform SIF type 1", "protein_names_refseq": "CG34418-PI; sif-PI; still life type 1; still life type 2; still life, isoform I; still life; still-life", "tax_id": 7227, "disease": "cataract 48 (Disease Ontology:DOID:0070354); neurodevelopmental disorder with language delay and seizures (Disease Ontology:DOID:0070444)", "pathway": " (dme:Dmel_CG34418); (R-DME-193648); (R-DME-3928662); (R-DME-3928665); (R-DME-416482); (R-DME-8980692); (R-DME-9013148); (R-DME-9013149); (R-DME-9013423); (R-DME-9958810)", "pathway_count": 10, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;30290152;35240055;8999801", "class_list": "", "function": "Regulates synaptic differentiation through the organization of actin cytoskeleton possibly by activating Rho-like GTPases. Is likely a factor in the cascade of Rac1 or Cdc42 in the neurons (PubMed:8999801). May play a role in maintaining proper septate junction functions. Required for eye development and most likely affects corneal lens-formation (PubMed:30290152)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VRN7", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0050803 regulation of synapse structure or activity;GO:0030036 actin cytoskeleton organization;GO:0007601 visual perception;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P91621-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29774-1", "uniprot_id": "ETS3_DROME", "mass": 52055.0, "length": 490, "protein_name": "DNA-binding protein D-ETS-3", "gene_name": "Ets65A", "organism": "Fruit fly", "refseq_name": "Ets at 65A, isoform B", "refseq_ac": "NP_523945", "gene_names_uniprotkb": "Ets65A; CG13294; CG6882; CG7018; D-Ets-3; D-ets-3; Dmel\\CG7018; Dmel_CG7018; ETS3; Ets3; Ets65a; Ets; ets65A", "gene_names_refseq": "CG13294; CG6882; CG7018; D-Ets-3; D-ets-3; Dmel\\CG7018; ETS3; Ets3; Ets65A; Ets65a; Ets; ets65A", "protein_names_uniprotkb": "DNA-binding protein D-ETS-3", "protein_names_refseq": "CG7018-PB; Ets at 65A, isoform B; Ets65A-PB", "tax_id": 7227, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); thrombocytopenia (Disease Ontology:DOID:1588); blood platelet disease (Disease Ontology:DOID:2218); systemic scleroderma (Disease Ontology:DOID:418); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); osteoarthritis (Disease Ontology:DOID:8398); myeloid leukemia (Disease Ontology:DOID:8692)", "pathway": " (dme:Dmel_CG7018); (R-DME-2559585)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1577186;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q86P68;Q95T62;Q95TB2;Q9VRU3;Q9VRU4;Q9VRU5", "ec_number_list": "", "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P29774-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07666-1", "uniprot_id": "SRYA_DROME", "mass": 59385.0, "length": 530, "protein_name": "Serendipity locus protein alpha", "gene_name": "Sry-alpha", "organism": "Fruit fly", "refseq_name": "serendipity alpha, isoform B", "refseq_ac": "NP_001303490", "gene_names_uniprotkb": "Sry-alpha; CG17957; Dmel\\CG17957; Dmel_CG17957; Sry alpha; Sry-a; Sryalpha; ser; sry alpha; sry-alpha; sry-a; sryalpha; srya; sry", "gene_names_refseq": "CG17957; Dmel\\CG17957; Sry alpha; Sry-alpha; Sryalpha; ser; sry alpha; sry-alpha; sry-a; sryalpha; srya; sry", "protein_names_uniprotkb": "Serendipity locus protein alpha", "protein_names_refseq": "CG17957-PB; Sry-alpha-PB; serendipity alpha, isoform B; serendipity alpha; serendipity-alpha", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17957); (R-DME-5218920); (R-DME-525793); (R-DME-9764561); (R-DME-9958825)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;2166703;25589440;26109356;26109357;3935797", "class_list": "", "function": "Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VAB4", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0032154 cleavage furrow;GO:0016342 catenin complex", "go_biological_process": "GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0098609 cell-cell adhesion;GO:0007349 cellularization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P07666-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MSG8-1", "uniprot_id": "APTX_DROME", "mass": 76477.0, "length": 662, "protein_name": "Aprataxin-like protein", "gene_name": "Aptx", "organism": "Fruit fly", "refseq_name": "aprataxin, isoform B", "refseq_ac": "NP_650805", "gene_names_uniprotkb": "Aptx; CG5316; Dmel\\CG5316; Dmel_CG5316", "gene_names_refseq": "Aptx; CG5316; Dmel\\CG5316", "protein_names_uniprotkb": "Aprataxin-like protein; 3.-.-.-", "protein_names_refseq": "Aptx-PB; CG5316-PB; aprataxin, isoform B", "tax_id": 7227, "disease": "early-onset ataxia with oculomotor apraxia and hypoalbuminemia (Disease Ontology:DOID:0050754); olivopontocerebellar atrophy (Disease Ontology:DOID:14784)", "pathway": " (dme:Dmel_CG5316)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V347;L0BID2;Q9VDX2;Q9VDX3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0003725 double-stranded RNA binding;GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000012 single strand break repair;GO:0000398 mRNA splicing, via spliceosome;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8MSG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20385-1", "uniprot_id": "CF2_DROME", "mass": 56750.0, "length": 510, "protein_name": "Chorion transcription factor Cf2", "gene_name": "Cf2", "organism": "Fruit fly", "refseq_name": "chorion factor 2, isoform A", "refseq_ac": "NP_523474", "gene_names_uniprotkb": "Cf2; BcDNA:GM09668; CF-2; CF2.5; CF2; CG11924; Cf2_II; Dmel\\CG11924; Dmel_CG11924; cf2", "gene_names_refseq": "BcDNA:GM09668; CF-2; CF2.5; CF2; CG11924; Cf2_II; Cf2; Dmel\\CG11924; cf2", "protein_names_uniprotkb": "Chorion transcription factor Cf2", "protein_names_refseq": "CG11924-PA; Cf2-PA; chorion Factor-2; chorion factor 2, isoform A; chorion factor 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11924)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1411512;16110336;17569856;17569867;2120114;25589440;26109356;26109357", "class_list": "", "function": "Transcriptional regulator; binds to the promoter region of Cp15. Also binds to its own promoter, thus having a probable autoregulatory role., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q01522;Q0IGV4;Q24263;Q5U0W7;Q86BN0;Q86BN1;Q9VR41", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0009953 dorsal/ventral pattern formation;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P20385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09077-1", "uniprot_id": "SCR_DROME", "mass": 44263.0, "length": 417, "protein_name": "Homeotic protein Sex combs reduced", "gene_name": "Scr", "organism": "Fruit fly", "refseq_name": "Sex combs reduced, isoform A", "refseq_ac": "NP_524248", "gene_names_uniprotkb": "Scr; BG:DS07876.2; CG1030; DmScr; Dmel\\CG1030; Dmel_CG1030; Msc; SCR; l(3)84Af; scr", "gene_names_refseq": "BG:DS07876.2; CG1030; DmScr; Dmel\\CG1030; Msc; SCR; Scr; l(3)84Af; scr", "protein_names_uniprotkb": "Homeotic protein Sex combs reduced", "protein_names_refseq": "CG1030-PA; Scr-PA; Sex combs reduced, isoform A; multi sex combs; multiple sex comb; sex combs reduced; sex-combs reduced", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1030)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12492146;12537568;12537572;12537573;12537574;16110336;16453653;1743486;17569856;17569867;18327897;25589440;2565809;26109356;26109357;7835693", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q23990;Q24508;Q9V3Q3", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007494 midgut development;GO:0009952 anterior/posterior pattern specification;GO:0045498 sex comb development;GO:0007432 salivary gland boundary specification", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P09077-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48462-1", "uniprot_id": "PP1B_DROME", "mass": 37740.0, "length": 330, "protein_name": "Serine/threonine-protein phosphatase beta isoform", "gene_name": "flw", "organism": "Fruit fly", "refseq_name": "flapwing, isoform C", "refseq_ac": "NP_001259407", "gene_names_uniprotkb": "flw; CG15305; CG2096; DmPp1-9C; Dmel\\CG2096; Dmel_CG2096; FLW; PP-1c; PP-1; PP1 9C; PP1 b9C; PP1 beta9c; PP1-9C; PP1-BETA-9C; PP19C; PP1B_DROME; PP1B; PP1beta-9C; PP1beta9C; PP1beta; PP1cbeta; PP1c; PP1; Pp1-9C; Pp1beta-9C; Pp1beta9C; XE55; anon-WO03040301.120; l(1)G0172", "gene_names_refseq": "CG15305; CG2096; DmPp1-9C; Dmel\\CG2096; FLW/PP1B; FLW; PP-1c; PP-1; PP1 9C; PP1 b9C; PP1 beta9c; PP19C; PP1B_DROME; PP1beta-9C; PP1beta9C; PP1beta; PP1cbeta; PP1c; PP1; Pp1-9C; Pp1beta-9C; Pp1beta9C; XE55; anon-WO03040301.120; flw; l(1)G0172", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase beta isoform; 3.1.3.16; Protein flap wing", "protein_names_refseq": "CG2096-PC; PP1beta9C; flap wing; flapwing, isoform C; flapwing; flw-PC; protein phosphatase 1beta at 9C; protein phosphatase 1", "tax_id": 7227, "disease": "Noonan syndrome-like disorder with loose anagen hair 2 (Disease Ontology:DOID:0080693); cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG2096); (R-DME-2565942); (R-DME-350416); (R-DME-350480); (R-DME-538898); (R-DME-5625740); (R-DME-5627123); (R-DME-9770562)", "pathway_count": 8, "publication_count": 21, "publication_id_list": "10570971;10712908;10731132;11301004;11874917;12537568;12537572;12537573;12537574;15269282;16110336;17007873;17569856;17569867;17575052;18327897;18412953;2176604;25589440;26109356;26109357", "class_list": "", "function": "Required for cell adhesion in non-muscle tissues and in maintenance of muscle attachment. Vital for larval development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W2V5", "ec_number_list": "2.7.7.19;2.7.11.1;3.1.3.16;3.1.3.48;2.7.7.6;3.6.4.13;3.6.5.2;2.7.11.21;3.1.3.27;3.1.27.-;3.1.3.-;3.1.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0017018 myosin phosphatase activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0014706 striated muscle tissue development;GO:0005981 regulation of glycogen catabolic process;GO:0007059 chromosome segregation;GO:0007155 cell adhesion;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P48462-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25228-1", "uniprot_id": "RAB3_DROME", "mass": 24862.0, "length": 220, "protein_name": "Ras-related protein Rab-3", "gene_name": "Rab3", "organism": "Fruit fly", "refseq_name": "Rab3, isoform A", "refseq_ac": "NP_523687", "gene_names_uniprotkb": "Rab3; AAF58762; CG7576; DRAB3; DRab3; DmRab3; Dmel\\CG7576; Dmel_CG7576; Drab3; P25228; Rab3A; dRab3; dm-Rab3; drab3; rab3", "gene_names_refseq": "AAF58762; CG7576; DRAB3; DRab3; DmRab3; Dmel\\CG7576; Drab3; P25228; Rab3A; Rab3; dRab3; dm-Rab3; drab3; rab3", "protein_names_uniprotkb": "Ras-related protein Rab-3", "protein_names_refseq": "CG7576-PA; Rab-protein 3; Rab3, isoform A; Rab3-PA", "tax_id": 7227, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG7576); (R-DME-181429); (R-DME-181430); (R-DME-210500); (R-DME-212676); (R-DME-264642); (R-DME-6798695); (R-DME-8873719); (R-DME-8876198); (R-DME-888590)", "pathway_count": 10, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14722103;16110336;1648935;17569856;17569867;25130366;25589440;25615965;26109356;26109357", "class_list": "", "function": "Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V5N9", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0048786 presynaptic active zone;GO:0031982 vesicle", "go_biological_process": "GO:0048789 cytoskeletal matrix organization at active zone;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0048790 maintenance of presynaptic active zone structure;GO:0015031 protein transport;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P25228-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q868T3-1", "uniprot_id": "CCAPR_DROME", "mass": 54492.0, "length": 494, "protein_name": "Cardioacceleratory peptide receptor", "gene_name": "CCAP-R", "organism": "Fruit fly", "refseq_name": "crustacean cardioactive peptide receptor, isoform C", "refseq_ac": "NP_996297", "gene_names_uniprotkb": "CCAP-R; CCAP receptor; CCAPR; CG14547; CG33344; CG6111; Ccap R; CcapR; DCCAPR; Dmel\\CG33344; Dmel_CG33344; anon-WO0170980.46; anon-WO0170980.47", "gene_names_refseq": "CCAP receptor; CCAP-R; CCAPR; CG14547; CG33344; CG6111; Ccap R; CcapR; DCCAPR; Dmel\\CG33344; anon-WO0170980.46; anon-WO0170980.47", "protein_names_uniprotkb": "Cardioacceleratory peptide receptor; Crustacean cardioactive peptide receptor", "protein_names_refseq": "CCAP receptor; CCAP-R-PC; CG33344-PC; cardioacceleratory peptide receptor; crustacean cardioactive peptide receptor, isoform C", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); childhood-onset asthma (Disease Ontology:DOID:0080815); nocturnal asthma (Disease Ontology:DOID:0080826); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); sleep disorder (Disease Ontology:DOID:535); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dme:Dmel_CG33344)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12177421;12537568;12537572;12537573;12537574;12646179;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Binds to the cardioactive peptide (CCAP), which is a neuropeptide., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "H5V8A1;Q8ITD2;Q9VBJ8", "ec_number_list": "", "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0018990 ecdysis, chitin-based cuticle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q868T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30052-1", "uniprot_id": "SCAL_DROME", "mass": 49658.0, "length": 440, "protein_name": "Protein scalloped", "gene_name": "sd", "organism": "Fruit fly", "refseq_name": "scalloped, isoform E", "refseq_ac": "NP_001096990", "gene_names_uniprotkb": "sd; CG8544; DROEXO2; DROEXO; Dmel\\CG8544; Dmel_CG8544; EP(X)1088; EP1088; SD; Sd; TEAD; anon-EST:Liang-2.14; clone 2.14; l(1)G0239; l(1)G0262; l(1)G0309; l(1)G0315; l(1)G0483; l(1)HF394; l(1)III; sp", "gene_names_refseq": "CG8544; DROEXO2; DROEXO; Dmel\\CG8544; EP(X)1088; EP1088; SD; Sd; TEAD; anon-EST:Liang-2.14; clone 2.14; l(1)G0239; l(1)G0262; l(1)G0309; l(1)G0315; l(1)G0483; l(1)HF394; l(1)III; sd; sp", "protein_names_uniprotkb": "Protein scalloped", "protein_names_refseq": "CG8544-PE; scalloped, isoform E; scalloped; sd-PE; spatula", "tax_id": 7227, "disease": "Sveinsson chorioretinal atrophy (Disease Ontology:DOID:0111228)", "pathway": " (dme:Dmel_CG8544); (R-DME-2032785); (R-DME-390193); (R-DME-8951671)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "10731132;11112330;11546746;12537568;12537572;12537573;12537574;12782275;1547938;16110336;17569856;17569867;17889654;18256197;18258485;18258486;18313299;19762509;25589440;26109356;26109357;8913756;9869635;9869643", "class_list": "", "function": "Transcription factor which plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Sd promotes nuclear localization of Yki. Involved in the regulation of cell-specific gene expression during development, particularly in the differentiation of the nervous system. When in combination with vestigial (vg) it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to vg switches the DNA target selectivity of sd. Required autonomously for cell proliferation and viability within the wing blade. Required for proper sensory organ precursor (SOP) differentiation at the wing margin; required for correct expression of sens. Involved in regulation of wing margin enhancer activity; cooperates with mam and Chi to regulate cut expression in the wing margin (PubMed:8913756)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXN7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007525 somatic muscle development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P30052-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24206-1", "uniprot_id": "BRC4_DROME", "mass": 92305.0, "length": 880, "protein_name": "Broad-complex core protein isoform 6", "gene_name": "br", "organism": "Fruit fly", "refseq_name": "broad, isoform H", "refseq_ac": "NP_001138144", "gene_names_uniprotkb": "br; 2B5; 2Bc; A18; BR-C Z1; BR-C; BR-Z1; BR-Z2; BR-Z3; BR-Z4; BR-c; BRC-Z1; BRC-Z2; BRC-Z3; BRC-Z4; BRC; BR_C; BR; Br-C Z2; Br-C-Z3; Br-C; Br-Z4; Br-c; BrC-Z1; BrC; BrZ3; Broad; Br; CG11491; CG11509; CG11511; CG11514; Dmel\\CG11491; Dmel_CG11491; EG:123F11.1; EG:17A9.1; EG:25D2.1; PP1; PP2; Z1; Z2; Z3; Z4; br-C; br-Z1; br-Z2; br-Z3; br-Z4; br-c; de12; ecs; l(1)2Bab; l(1)2Bad; l(1)2Ba; l(1)2Bb; l(1)2Bc; l(1)2Bd; l(1)ESHS5; l(1)G0018; l(1)G0042; l(1)G0284a; l(1)G0284; l(1)G0318; l(1)G0401; l(1)PP1; l(1)d norm-12; l(1)d.norm.1; l(1)dn1; l(1)n34; l(1)npr-1; l(1)npr1; l(1)pp-1; l(1)pp-2; l(1)pp1; l(1)pp2; l(1)ts132; l(1)ts144; l(1)ts358; l(1)ts376; npr-1; npr1; nprl; npr; nrp1; nrp; o.c.c; rbp; rdp; rds; uq", "gene_names_refseq": "2B5; 2Bc; A18; BR-C Z1; BR-C; BR-Z1; BR-Z2; BR-Z3; BR-Z4; BR-c; BRC-Z1; BRC-Z2; BRC-Z3; BRC-Z4; BRC; BR_C; BR; Br-C Z2; Br-C-Z3; Br-C; Br-Z4; Br-c; BrC-Z1; BrC; BrZ3; Broad; Br; CG11491; CG11509; CG11511; CG11514; Dmel\\CG11491; EG:123F11.1; EG:17A9.1; EG:25D2.1; PP1; PP2; Z1; Z2; Z3; Z4; br-C; br-Z1; br-Z2; br-Z3; br-Z4; br-c; br; de12; ecs; l(1)2Bab; l(1)2Bad; l(1)2Ba; l(1)2Bb; l(1)2Bc; l(1)2Bd; l(1)ESHS5; l(1)G0018; l(1)G0042; l(1)G0284a; l(1)G0284; l(1)G0318; l(1)G0401; l(1)PP1; l(1)d norm-12; l(1)d.norm.1; l(1)dn1; l(1)n34; l(1)npr-1; l(1)npr1; l(1)pp-1; l(1)pp-2; l(1)pp1; l(1)pp2; l(1)ts132; l(1)ts144; l(1)ts358; l(1)ts376; npr-1; npr1; nprl; npr; nrp1; nrp; o.c.c.; rbp; rdp; rds; uq", "protein_names_uniprotkb": "Broad-complex core protein isoform 6", "protein_names_refseq": "Br-C; CG11491-PH; br-PH; broad complex; broad, isoform H; broad-complex; ecdysone-sensitivity; lethal(1)2Bab; lethal(1)2Bc; lethal(1)2Bd; lethal(1)discs normal; lethal(1)non-pupariating-1; non-pupariating; overlapping-complementation-complex; reduced bristles on palps; reduced palps; unequal wings", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11491)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;1743483;17569856;17569867;25589440;26109356;26109357;8223281;8660872;9242423", "class_list": "", "function": "Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O46064;Q9W575", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001217 DNA-binding transcription repressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0043025 neuronal cell body;GO:0005700 polytene chromosome", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006914 autophagy;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q24206-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SWR3-1", "uniprot_id": "SPR_DROME", "mass": 50323.0, "length": 435, "protein_name": "Sex peptide receptor", "gene_name": "SPR", "organism": "Fruit fly", "refseq_name": "Sex peptide receptor, isoform C", "refseq_ac": "NP_001284892", "gene_names_uniprotkb": "SPR; CG12731; CG16752; Dmel\\CG16752; Dmel_CG16752; DrmSPR; SP-R; Spr; spr", "gene_names_refseq": "CG12731; CG16752; Dmel\\CG16752; DrmSPR; SP-R; SPR; Spr; spr", "protein_names_uniprotkb": "Sex peptide receptor", "protein_names_refseq": "CG16752-PC; SP receptor; SPR-PC; Sex peptide receptor, isoform C; Sex peptide receptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16752)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18066048;20308537;20458515;24089336;25333796;25589440;26109356;26109357", "class_list": "", "function": "Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior (PubMed:18066048, PubMed:20308537, PubMed:20458515, PubMed:24089336, PubMed:25333796). MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons (PubMed:25333796). SP-SPR is one of the multiple SP pathways that induce female post-mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying (PubMed:18066048, PubMed:24089336). The PMR switch is achieved by mediating the synaptic output of neurons such as those expressing fruitless (fru), double sex (dsx) and pickpocket (ppk) (PubMed:18066048, PubMed:24089336)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W4B9", "ec_number_list": "", "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045434 negative regulation of female receptivity, post-mating;GO:0046662 regulation of egg-laying behavior", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8SWR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q23977-1", "uniprot_id": "HEP_DROME", "mass": 125108.0, "length": 1178, "protein_name": "Dual specificity mitogen-activated protein kinase kinase hemipterous", "gene_name": "hep", "organism": "Fruit fly", "refseq_name": "hemipterous, isoform E", "refseq_ac": "NP_001259501", "gene_names_uniprotkb": "hep; CG2190; CG4353; D-MKK7; DJNKK; DMKK7; Dmel\\CG4353; Dmel_CG4353; HEP; Hep; JNKK; Jnkk; MAP2K7; MAPKK; MKK7; Mkk7; dJNKK; dMKK7; hem; hp; hrp; l(1)7P1; l(1)G0107; l(1)G0208", "gene_names_refseq": "CG2190; CG4353; D-MKK7; DHEP/MKK7; DJNKK; DMKK7; Dmel\\CG4353; HEP/MKK7; HEP; Hep/Mkk7; Hep; JNKK; Jnkk; MAP2K7; MAPKK; MKK7; Mkk7; dJNKK; dMKK7; hem; hep/JNKK; hep; hp; hrp; l(1)7P1; l(1)G0107; l(1)G0208", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase hemipterous; 2.7.12.2; MAPKK", "protein_names_refseq": "CG4353-PE; JNK kinase; JNK-Kinase; Mitogen-activated protein kinase kinase 7; hemipterous, isoform E; hemipterous; hemipterus; hempiterous; hep-PE", "tax_id": 7227, "disease": "heart disease (Disease Ontology:DOID:114); colon adenocarcinoma (Disease Ontology:DOID:234); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); schizophrenia (Disease Ontology:DOID:5419); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dme:Dmel_CG4353); (R-DME-209397); (R-DME-209447); (R-DME-350376)", "pathway_count": 4, "publication_count": 27, "publication_id_list": "10469646;10731132;11865058;12537568;12537569;12537572;12537573;12537574;14519762;16081424;16110336;16311020;16894030;17158449;17192257;17569856;17569867;18327897;25589440;26109356;26109357;8137421;8521475;8946915;9207092;9472024;9694801", "class_list": "", "function": "Required for the epithelial cell sheet movement called dorsal closure (DC), which allows establishment of the dorsal epidermis. Controls the expression in the dorsal epithelium edges of another dorsal closure gene, puckered (puc). Phosphorylates and activates the MAP kinase bsk; bsk signal transduction pathway mediates an immune response and morphogenesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O18411;Q8SZ04;Q8SZZ1;Q9I7S3", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.10.1;2.7.11.22;2.7.11.21;2.7.10.2;5.6.1.8;2.7.11.11;2.7.11.23;2.3.2.23;3.6.5.2;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.11.39", "go_molecular_function": "GO:0008545 JUN kinase kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0033500 carbohydrate homeostasis;GO:0010628 positive regulation of gene expression;GO:0019731 antibacterial humoral response;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q23977-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39768-1", "uniprot_id": "OPA_DROME", "mass": 66238.0, "length": 609, "protein_name": "Pair-rule protein odd-paired", "gene_name": "opa", "organism": "Fruit fly", "refseq_name": "odd paired, isoform A", "refseq_ac": "NP_524228", "gene_names_uniprotkb": "opa; CG1133; Dmel\\CG1133; Dmel_CG1133; Opa", "gene_names_refseq": "CG1133; Dmel\\CG1133; Opa; opa", "protein_names_uniprotkb": "Pair-rule protein odd-paired", "protein_names_refseq": "CG1133-PA; GLI-Kr zinc finger pair-rule protein; Odd paired; Odd-paired; odd paired, isoform A; opa-PA", "tax_id": 7227, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Joubert syndrome (Disease Ontology:DOID:0050777); visceral heterotaxy 1 (Disease Ontology:DOID:0051016); right atrial isomerism (Disease Ontology:DOID:0060856); spina bifida (Disease Ontology:DOID:0080016); holoprosencephaly 5 (Disease Ontology:DOID:0110878); X-linked VACTERL association (Disease Ontology:DOID:0111766); Dandy-Walker syndrome (Disease Ontology:DOID:2785); Goldenhar syndrome (Disease Ontology:DOID:2907); holoprosencephaly (Disease Ontology:DOID:4621); schizophrenia (Disease Ontology:DOID:5419); visceral heterotaxy 5 (Disease Ontology:DOID:758)", "pathway": " (dme:Dmel_CG1133)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7781900;8288124", "class_list": "", "function": "Transcription factor essential for parasegmental subdivision of the embryo. It is involved in the activation of wingless (wg) in odd parasegments. It is also required for the timely activation of wg in the remaining parasegments and for the timely activation of engrailed (en) in all parasegments., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ21;Q960Y0;Q9VN66", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007494 midgut development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P39768-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54361-1", "uniprot_id": "OAZ_DROME", "mass": 28283.0, "length": 254, "protein_name": "Ornithine decarboxylase antizyme", "gene_name": "Oda", "organism": "Fruit fly", "refseq_name": "ornithine decarboxylase antizyme, isoform A", "refseq_ac": "NP_725103", "gene_names_uniprotkb": "Oda; AZ; CG16747; D-AZ; Dmel\\CG16747; Dmel_CG16747; ODA; guf; l(2)02833; l(2)k09037; oda", "gene_names_refseq": "AZ; CG16747; D-AZ; Dmel\\CG16747; ODA; Oda; guf; l(2)02833; l(2)k09037; oda", "protein_names_uniprotkb": "Ornithine decarboxylase antizyme; ODC-Az; Protein gutfeeling", "protein_names_refseq": "CG16747-PA; Oda-PA; gut feeling; gutfeeling; ornithine deacarboxylase antizyme; ornithine decarboxylase antizyme, isoform A; ornithine decarboxylase antizyme; orthinine decarboyxlase antizyme", "tax_id": 7227, "disease": "brain ischemia (Disease Ontology:DOID:2316); coronary restenosis (Disease Ontology:DOID:4247)", "pathway": " (dme:Dmel_CG16747); (R-DME-350562); (R-DME-351202)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8878684;9488472", "class_list": "", "function": "Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (By similarity). Required for cellular differentiation in neuronal and myogenic lineages during embryonic development (PubMed:8878684)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O44436", "ec_number_list": "", "go_molecular_function": "GO:0008073 ornithine decarboxylase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P54361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27331-1", "uniprot_id": "VATA2_DROME", "mass": 68302.0, "length": 614, "protein_name": "V-type proton ATPase catalytic subunit A isoform 2", "gene_name": "Vha68-2", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase 68 kDa subunit 2, isoform D", "refseq_ac": "NP_001246015", "gene_names_uniprotkb": "Vha68-2; A subunit; ATP6V1A; CG3762; Dmel\\CG3762; Dmel_CG3762; MENE-R6; RE30552p; VATA; VHAA2; Vha6-2; Vha68.2; Vha68; l(2)01510; l(2)s4214; vha67-2; vha68-2", "gene_names_refseq": "A subunit; ATP6V1A; CG3762; Dmel\\CG3762; MENE-R6; RE30552p; VATA; Vha6-2; Vha68-2; Vha68.2; Vha68; l(2)01510; l(2)s4214; vha67-2; vha68-2", "protein_names_uniprotkb": "V-type proton ATPase catalytic subunit A isoform 2; 7.1.2.2; V-ATPase 69 kDa subunit 2; V-ATPase subunit A 2; Vacuolar proton pump subunit alpha 2", "protein_names_refseq": "CG3762-PD; V-ATPase 69 kDa subunit 2; V-ATPase V1 subunit A1; Vha68-2-PD; vacuolar ATPase; vacuolar H[+] ATPase 68 kDa subunit 2, isoform D; vacuolar H[+] ATPase subunit 68-2", "tax_id": 7227, "disease": "autosomal recessive cutis laxa type IID (Disease Ontology:DOID:0070129); developmental and epileptic encephalopathy 93 (Disease Ontology:DOID:0112275)", "pathway": " (dme:Dmel_CG3762); (R-DME-1222556); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;9050231", "class_list": "", "function": "Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXT2;Q9VK48", "ec_number_list": "7.1.2.2;2.7.11.1;3.6.5.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0016197 endosomal transport;GO:0046034 ATP metabolic process;GO:0048388 endosomal lumen acidification;GO:1902600 proton transmembrane transport;GO:0007446 imaginal disc growth", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q27331-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01083-1", "uniprot_id": "SPITZ_DROME", "mass": 26424.0, "length": 234, "protein_name": "Protein spitz", "gene_name": "spi", "organism": "Fruit fly", "refseq_name": "spitz, isoform G", "refseq_ac": "NP_001027281", "gene_names_uniprotkb": "spi; CG10334; CT29014; Dmel\\CG10334; Dmel_CG10334; EP(2)2378; Spitz; Spi; anon-WO0118547.158; l(2)01068; l(2)37Fa; l(2)s3547; s-spi; s.spi; sSpi", "gene_names_refseq": "CG10334; CT29014; Dmel\\CG10334; EP(2)2378; Spitz; Spi; anon-WO0118547.158; l(2)01068; l(2)37Fa; l(2)s3547; s-spi; s.spi; sSpi; spi", "protein_names_uniprotkb": "Protein spitz", "protein_names_refseq": "CG10334-PG; epidermal growth factor protein; spi-PG; spitz, isoform G; spitz", "tax_id": 7227, "disease": "intestinal cancer (Disease Ontology:DOID:10155); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG10334)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;11672524;11790319;12537568;12537569;12537572;12537573;12537574;16110336;1644292;17569856;17569867;18500331;25589440;26109356;26109357;7833286", "class_list": "", "function": "Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXE0;Q9VIT4", "ec_number_list": "", "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q01083-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00168-1", "uniprot_id": "KCC2A_DROME", "mass": 59920.0, "length": 530, "protein_name": "Calcium/calmodulin-dependent protein kinase type II alpha chain", "gene_name": "CaMKII", "organism": "Fruit fly", "refseq_name": "Calcium/calmodulin-dependent protein kinase II, isoform G", "refseq_ac": "NP_001014696", "gene_names_uniprotkb": "CaMKII; CAMKIIalpha; CAMKIId; CAMKII; CDPK1; CG18069; CaM II; CaM KII; CaM kinase; CaMK II; CaMK-II; CaMKii; CaM; CamK-II; CamKIIalpha; CamKII; Camkii; Cam; DCK; Dmel\\CG18069; Dmel_CG18069; camKII; camk II; camkII; camkii; dCAMKII; dCaMKII; l(4)102EFb; l(4)16; l(4)ar", "gene_names_refseq": "CAMKIIalpha; CAMKIId; CAMKII; CDPK1; CG18069; Ca2+/calmodulin-dependent protein kinase II; CaM II; CaM KII; CaM kinase; CaMK II; CaMK-II; CaMKII; CaMKii; CaM; Calcium/calmodulin-dependent protein kinase; CamK-II; CamKIIalpha; CamKII; Camkii; Cam; DCK; Dmel\\CG18069; calcium/calmodulin-dependent protein kinase II; camKII; camk II; camkII; camkii; dCAMKII; dCaMKII; l(4)102EFb; l(4)16; l(4)ar", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II alpha chain; 2.7.11.17; CaM-kinase II alpha chain", "protein_names_refseq": "CG18069-PG; Ca2+ calmodulin-dependent kinase II; Ca2+/calmodulin-dependent protein kinase II; CaM kinase II; CaM kinase; CaM-kinase-II; CaMKII-PG; Ca[2+]-calmodulin-dependent protein kinase II; Ca[2+]/calmodulin-dependent protein kinase II; Calcium/calmodulin-dependent protein kinase II, isoform G; Calcium/calmodulin-dependent protein kinase ii; calcium/ calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase type II; calmodulin kinase II; lethal (4) 102EFb", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 59 (Disease Ontology:DOID:0061033); autosomal dominant intellectual developmental disorder 53 (Disease Ontology:DOID:0080228); autosomal dominant intellectual developmental disorder 54 (Disease Ontology:DOID:0080230); autosomal recessive intellectual developmental disorder 63 (Disease Ontology:DOID:0081224); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); renovascular hypertension (Disease Ontology:DOID:1591); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG18069); (R-DME-3371571); (R-DME-4086398); (R-DME-438066); (R-DME-5578775); (R-DME-5673000); (R-DME-936837)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10731132;11980904;12537568;12537572;12537573;12537574;14687552;16110336;16880127;17569856;17569867;18327897;1910789;23543616;24062638;25003749;25009461;25589440;26109356;26109357;32471994;8380587;8397298", "class_list": "", "function": "A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q59DP1;Q59DP2;Q9V495", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;3.6.5.2;5.6.1.8;2.7.11.11;7.2.2.10;2.7.11.23;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;2.7.11.39", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0008049 male courtship behavior;GO:0010888 negative regulation of lipid storage;GO:0007528 neuromuscular junction development;GO:0007611 learning or memory;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q00168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47825-1", "uniprot_id": "TAF4_DROME", "mass": 99338.0, "length": 921, "protein_name": "Transcription initiation factor TFIID subunit 4", "gene_name": "Taf4", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 4, isoform F", "refseq_ac": "NP_001163453", "gene_names_uniprotkb": "Taf4; CG5444; Dmel\\CG5444; Dmel_CG5444; SR3-3; SY3-2 TAF110; TAF110; TAF4; TAFII110; TAF[II]110; TAF[[II]]110; TAF[[II]]; TAF; TFIID 110; TFIID; Taf110; Taf[[II]]110; d110; dTAF4; dTAFII110; dTAF[[II]]110; dmTAF4; l(3)72Dj; p110; taf110; taf4", "gene_names_refseq": "CG5444; Dmel\\CG5444; SR3-3; SY3-2 TAF110; TAF110; TAF4; TAFII110; TAF[II]110; TAF[[II]]110; TAF[[II]]; TAF; TFIID 110; TFIID; Taf110; Taf4; Taf[[II]]110; d110; dTAF4; dTAFII110; dTAF[[II]]110; dmTAF4; l(3)72Dj; p110; taf110; taf4", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 4; 110 kDa TBP-associated factor; TAFII-110; Transcription initiation factor TFIID 110 kDa subunit; p110", "protein_names_refseq": "CG5444-PF; TATA-associated factor 110; TBP associated factor 110; TBP-associated factor 110kD; TBP-associated factor 110; TBP-associated factor 4, isoform F; Taf4-PF; lethal(3)72Dj", "tax_id": 7227, "disease": "autosomal dominant intellectual developmental disorder 73 (Disease Ontology:DOID:0061046); spermatogenic failure 13 (Disease Ontology:DOID:0070182)", "pathway": " (dme:Dmel_CG5444); (R-DME-674695); (R-DME-6804756); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;28604694;40245499;7678780;8224849;8247000;8276241;8327460;8464492", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May function as a coactivator by serving as a site of protein-protein contact between activators like Sp1 (or btd) and TFIID complex., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P49845;Q0E8E3;Q1LZ31;Q8T9E0;Q9VUY7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0140297 DNA-binding transcription factor binding;GO:0001092 TFIIA-class transcription factor complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P47825-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08181-1", "uniprot_id": "CSK2A_DROME", "mass": 39960.0, "length": 336, "protein_name": "Casein kinase II subunit alpha", "gene_name": "CkIIalpha", "organism": "Fruit fly", "refseq_name": "casein kinase IIalpha, isoform D", "refseq_ac": "NP_001036624", "gene_names_uniprotkb": "CkIIalpha; 08; CG17520; CJIIalpha; CK II; CK-2; CK-II alpha; CK-II; CK2 alpha; CK2-alpha; CK2alpha; CK2a; CK2; CKII alpha; CKII-alpha; CKIIalfa; CKIIalpha; CKIIa; CKII; Cask-II-a; Ck2alpha; CkIIa; CkII; Dm-CK2-alpha; DmCK2alpha; DmCKIIalpha; Dmel\\CG17520; Dmel_CG17520; Tik; alphaCK2; anon-WO02059370.53; ck2alpha; ckIIalpha; dCK2alpha; dCKII alpha; dCKII; l(3)S095808", "gene_names_refseq": "0958/08; CG17520; CJIIalpha; CK II; CK-2; CK-II alpha; CK-II; CK2 alpha; CK2-alpha; CK2alpha; CK2a; CK2; CKII alpha; CKII-alpha; CKIIalfa; CKIIalpha; CKIIa; CKII; Cask-II-a; Ck2alpha; CkIIalpha; CkIIa; CkII; Dm-CK2-alpha; DmCK2alpha; DmCKIIalpha; Dmel\\CG17520; Tik; alphaCK2; anon-WO02059370.53; ck2alpha; ckIIalpha; dCK2alpha; dCKII alpha; dCKII; l(3)S095808", "protein_names_uniprotkb": "Casein kinase II subunit alpha; 2.7.11.1; CK II subunit alpha", "protein_names_refseq": "CG17520-PD; CkIIalpha-PD; NAP1-kinase; alpha subunit of drosophila casein kinase II; casein kinase 2; casein kinase II alpha subunit; casein kinase II-alpha subunit; casein kinase IIalpha, isoform D; lethal (3) S095808; protein kinase CK2; timekeeper", "tax_id": 7227, "disease": "male infertility (Disease Ontology:DOID:12336); breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG17520); (R-DME-201688); (R-DME-209190); (R-DME-209214); (R-DME-2514853); (R-DME-432553); (R-DME-445144); (R-DME-6804756); (R-DME-6814122); (R-DME-8934903); (R-DME-8948751)", "pathway_count": 11, "publication_count": 55, "publication_id_list": "10409506;10477300;10557210;10731132;11430804;11440719;11912487;11955435;12122057;12432393;12442174;12447397;12537568;12537569;12537572;12537573;12537574;12563262;12663920;12944510;14759367;15300262;15563523;15592457;15598741;15616566;15875013;16041759;16110336;16319317;16326393;16410523;16630821;17077139;17418796;17569856;17569867;17925225;18593878;18815259;24615015;25589440;26109356;26109357;3119988;3468112;7481773;8596938;8600384;8898207;8906787;8906794;8938123;9482888;9674431", "class_list": "", "function": "Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8B4;Q9W5T2", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;3.6.5.2;5.6.1.8;2.7.11.11;2.7.11.23;3.1.3.16;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;2.7.11.39", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005956 protein kinase CK2 complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0046331 lateral inhibition;GO:0048749 compound eye development;GO:0000278 mitotic cell cycle;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 5.6, "record_id": "P08181-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40689-1", "uniprot_id": "TSL_DROME", "mass": 41210.0, "length": 353, "protein_name": "Torso-like protein", "gene_name": "tsl", "organism": "Fruit fly", "refseq_name": "torso-like, isoform C", "refseq_ac": "NP_001262810", "gene_names_uniprotkb": "tsl; CG6705; Dm-tsl; Dmel\\CG6705; Dmel_CG6705; Torso-like; Tsl; fs(3)00617", "gene_names_refseq": "CG6705; Dm-tsl; Dmel\\CG6705; Torso-like; Tsl; fs(3)00617; tsl", "protein_names_uniprotkb": "Torso-like protein", "protein_names_refseq": "CG6705-PC; Torso-like; fs(3)torso-like; torso like; torso-like, isoform C; torsolike; tsl-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6705)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12814553;16110336;17569856;17569867;17893096;25589440;26109356;26109357;40245499;8107870;8276237", "class_list": "", "function": "Probable ligand that binds to the torso receptor. Implicated in a receptor tyrosine kinase signaling pathway that specifies terminal cell fate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9VD80", "ec_number_list": "", "go_molecular_function": "GO:0030546 signaling receptor activator activity;GO:0005122 torso binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007281 germ cell development;GO:0040018 positive regulation of multicellular organism growth;GO:0009880 embryonic pattern specification;GO:0008358 maternal determination of anterior/posterior axis, embryo;GO:0110074 positive regulation of apical constriction involved in ventral furrow formation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40689-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07909-1", "uniprot_id": "ROA1_DROME", "mass": 39038.0, "length": 365, "protein_name": "Heterogeneous nuclear ribonucleoprotein A1", "gene_name": "Hrb98DE", "organism": "Fruit fly", "refseq_name": "heterogeneous nuclear ribonucleoprotein at 98DE, isoform B", "refseq_ac": "NP_524543", "gene_names_uniprotkb": "Hrb98DE; B1; CG9983; Dmel\\CG9983; Dmel_CG9983; E7Delta6; HDP(P9); HRB98DE; Hrb1; Hrb98 de; Hrp38; Pen9; anon-E7Delta6; hrb98 de; hrb98DE; hrb98de; hrp38; p9", "gene_names_refseq": "CG9983; Dmel\\CG9983; E7Delta6; HDP(P9); HRB98DE/hrp38; HRB98DE; Hrb1; Hrb98 de; Hrb98DE/Hrp38; Hrb98DE; Hrp38; Pen9; anon-E7Delta6; hnRNP A2/B1; hrb98 de; hrb98DE; hrb98de; hrp38; p9", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A1; PEN repeat clone P9; hnRNP A1; hnRNP core protein A1-A", "protein_names_refseq": "CG9983-PB; Hrb98DE-PB; heterogeneous nuclear ribonucleoprotein at 98DE, isoform B; hnRNA-binding protein 1; s", "tax_id": 7227, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); amyotrophic lateral sclerosis type 20 (Disease Ontology:DOID:0060211); distal myopathy 3 (Disease Ontology:DOID:0111189); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2 (Disease Ontology:DOID:0111384); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 (Disease Ontology:DOID:0111386); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); transient cerebral ischemia (Disease Ontology:DOID:224); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic carcinoma (Disease Ontology:DOID:4905); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dme:Dmel_CG9983)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;2104660;25589440;26109356;26109357;3031652", "class_list": "", "function": "This protein is a component of ribonucleosomes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24359;Q24360;Q99361;Q9VAU7;Q9VAU8", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0043565 sequence-specific DNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0048027 mRNA 5'-UTR binding;GO:0034046 poly(G) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:1990904 ribonucleoprotein complex;GO:0005703 polytene chromosome puff", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0045727 positive regulation of translation;GO:0048477 oogenesis;GO:0033119 negative regulation of RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P07909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q94511-1", "uniprot_id": "NDUS1_DROME", "mass": 78630.0, "length": 731, "protein_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "gene_name": "ND-75", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase (ubiquinone) 75 kDa subunit, isoform A", "refseq_ac": "NP_511083", "gene_names_uniprotkb": "ND-75; CG2286; Dmel\\CG2286; Dmel_CG2286; ND75; NDUFS1; NDUS1; NUAM; dNDUFS1", "gene_names_refseq": "CG2286; Dmel\\CG2286; ND-75; ND75; NDUFS1; NDUS1; NUAM; dNDUFS1", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; 7.1.1.2; CI-75kD; Complex I-75kD", "protein_names_refseq": "CG2286-PA; FBpp0071128; NADH dehydrogenase (ubiquinone) 75 kDa subunit, isoform A; NADH ubiquinone oxidoreductase 75 kDa; NADH-ubiquinone oxidoreductase 75 kDa subunit; NADH:ubiquinone oxidoreductase 75 kDa subunit; NADH:ubiquinone reductase 75 kDa subunit; NADH:ubiquinone reductase 75-kD subunit precursor; NADH:ubiquinone reductase 75kD subunit precursor; ND-75-PA", "tax_id": 7227, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 5 (Disease Ontology:DOID:0112068); inherited metabolic disorder (Disease Ontology:DOID:655); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG2286); (R-DME-611105); (R-DME-6799198); (R-DME-9837999)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10071211;10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9W3H1", "ec_number_list": "2.7.1.23;1.1.1.40;1.1.1.38;1.1.1.39;1.2.4.2;1.1.1.35;1.1.1.-;1.1.1.62;1.1.1.51;1.1.1.53;2.3.1.37;3.5.3.1;7.1.1.2;1.4.1.3;2.7.11.2;2.7.11.-;7.1.2.2;1.2.4.1;3.4.21.53;6.2.1.4;4.98.1.1;1.-.-.-;1.1.1.239;1.1.1.37;2.1.1.320;4.2.1.3;3.4.21.92;5.6.2.3;1.2.1.3;6.1.1.5;1.8.1.4;1.3.8.1;1.3.8.5;1.1.1.41;2.3.1.-;2.8.3.5;2.3.-.-;2.3.1.9;4.2.1.2;2.3.3.16;5.3.3.21", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0072593 reactive oxygen species metabolic process;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0045333 cellular respiration;GO:0042773 ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q94511-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36188-1", "uniprot_id": "TNNI_DROME", "mass": 30082.0, "length": 269, "protein_name": "Troponin I", "gene_name": "wupA", "organism": "Fruit fly", "refseq_name": "wings up A, isoform C", "refseq_ac": "NP_523398", "gene_names_uniprotkb": "wupA; CG7178; DROTROPONI; DmTpnI; Dmel\\CG7178; Dmel_CG7178; HDP; HL-I; HL08042; HLI; Hdp; Tn I; TnI; TpnI; WupA; chrX:17947374..17947524; fliH; hdp-a; hdp2; hdp; wup-A; wupa", "gene_names_refseq": "CG7178; DROTROPONI; DmTpnI; Dmel\\CG7178; HDP; HL-I; HL08042; HLI; Hdp; Tn I; TnI; TpnI; WupA; chrX:17947374..17947524; fliH; hdp-a; hdp2; hdp; wup-A; wupA; wupa", "protein_names_uniprotkb": "Troponin I; Protein heldup; Protein wings apart-A; Tn I", "protein_names_refseq": "CG7178-PC; flightless H; flightless-H; haplo-lethal region I; held up; held-up2; heldup-a; troponin I; troponin-I; wings up A, isoform C; wings up; wings-up A; wupA-PC", "tax_id": 7227, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); hypertrophic cardiomyopathy 7 (Disease Ontology:DOID:0110313); dilated cardiomyopathy 1FF (Disease Ontology:DOID:0110459); dilated cardiomyopathy 2A (Disease Ontology:DOID:0110460); familial restrictive cardiomyopathy 1 (Disease Ontology:DOID:0111425); distal arthrogryposis type 2B1 (Disease Ontology:DOID:0111600); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299); coronary artery disease (Disease Ontology:DOID:3393); restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (dme:Dmel_CG7178); (R-DME-5578775)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;1899228;1908472;25589440;26109356;26109357;7680094", "class_list": "", "function": "Troponin I is the ATPase inhibitory subunit of troponin in the thin filament regulatory complex. Involved in the development and maintenance of muscle and nervous system. May also be involved in the cytoskeletal apparatus., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KHR0;Q9VWY1;Q9VWY2;Q9VWY3;Q9VWY4", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005865 striated muscle thin filament;GO:0005861 troponin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0007399 nervous system development;GO:0007507 heart development;GO:0046716 muscle cell cellular homeostasis;GO:0060047 heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36188-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q94981-1", "uniprot_id": "ARI1_DROME", "mass": 58932.0, "length": 503, "protein_name": "E3 ubiquitin-protein ligase ariadne-1", "gene_name": "ari-1", "organism": "Fruit fly", "refseq_name": "ariadne 1, isoform D", "refseq_ac": "NP_001245736", "gene_names_uniprotkb": "ari-1; AAS65398.1; ARI1_DROME; Ari-1; CG5659; Dmel\\CG5659; Dmel_CG5659; HL-V; ari-1a; ari; l(1)16Fj", "gene_names_refseq": "AAS65398.1; ARI1_DROME; Ari-1; CG5659; Dmel\\CG5659; HL-V; ari-1a; ari-1; ari; l(1)16Fj", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ariadne-1; 2.3.2.31; Protein ariadne-1; RING-type E3 ubiquitin transferase ariadne-1", "protein_names_refseq": "Ariadne-1; CG5659-PD; ari-1-PD; ariadne 1, isoform D; ariadne", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5659)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10880484;12537568;12537572;12537573;12537574;16110336;17569856;17569867;21900267;25589440;26109356;26109357;29689197", "class_list": "", "function": "Atypical E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 Ubc10 (PubMed:10880484, PubMed:21900267, PubMed:29689197). Controls the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex (PubMed:29689197). Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation (PubMed:29689197). Appears to function, at least partially redundantly, with the RBR E3 ligase family member park in nuclear localization and morphology (PubMed:29689197). Likely to function in metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and its heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A (PubMed:21900267)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KHQ9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0048477 oogenesis;GO:0007029 endoplasmic reticulum organization;GO:0050769 positive regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q94981-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K556-1", "uniprot_id": "TTD14_DROME", "mass": 54337.0, "length": 475, "protein_name": "TRPL translocation defect protein 14", "gene_name": "Ttd14", "organism": "Fruit fly", "refseq_name": "TRPL translocation defect 14, isoform B", "refseq_ac": "NP_001097365", "gene_names_uniprotkb": "Ttd14; CG16859; CG30118; CG5544; Dmel\\CG30118; Dmel_CG30118; TTD14; l(2)08770; l(2)k04808; ttd14", "gene_names_refseq": "CG16859; CG30118; CG5544; Dmel\\CG30118; TTD14; Ttd14; l(2)08770; l(2)k04808; ttd14", "protein_names_uniprotkb": "TRPL translocation defect protein 14", "protein_names_refseq": "CG30118-PB; TRPL translocation defect 14, isoform B; Ttd14-PB; lethal (2) 08770", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30118)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26509977", "class_list": "", "function": "GTP-binding protein which is required for the light-dependent internalization of the TRPL ion channel from the rhabdomere on the apical surface of photoreceptor cells to the cell body and for the recycling of TRPL back to the rhabdomere in the dark. Binds to 3-phosphoinositide (PtdIns(3)P) and phosphatic acid and so may interact with membranes, particularly the early endosome membrane where PtdIns(3)P is predominantly localized. Plays a role in preventing photoreceptor degeneration., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8DYI1", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0035091 phosphatidylinositol binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0045494 photoreceptor cell maintenance;GO:0090316 positive regulation of intracellular protein transport;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7K556-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35500-1", "uniprot_id": "SCNA_DROME", "mass": 239362.0, "length": 2131, "protein_name": "Sodium channel protein para", "gene_name": "para", "organism": "Fruit fly", "refseq_name": "paralytic, isoform B", "refseq_ac": "NP_001036280", "gene_names_uniprotkb": "para; CG9907; DmNa[[V]]; DmNa[[v]]1; DmNa[[v]]; DmNav1; DmNav; Dmel\\CG9907; Dmel_CG9907; Nav1; Ocd; Para; Scn1alpha; Shudderer; Shu; VSSC; bas; bss; l(1)14Da; l(1)ESHS48; lincRNA.S9469; olfD; para13-5; par; sbl-1; sbl", "gene_names_refseq": "CG9907; DmNa[[V]]; DmNa[[v]]1; DmNa[[v]]; DmNav1; DmNav; Dmel\\CG9907; Nav1; Ocd; Para; Scn1alpha; Shudderer; Shu; VSSC; bas; bss; l(1)14Da; l(1)ESHS48; lincRNA.S9469; olfD; para13-5; para; par; sbl-1; sbl", "protein_names_uniprotkb": "Sodium channel protein para; DmNav1; Protein paralytic; Sodium channel 1", "protein_names_refseq": "CG9907-PB; Out cold; Out-cold; bang senseless; bang sensitive; bang-senseless; bangsenseless; para-PB; paralytic, isoform B; paralytic; paralyzed; shudderer; smell-blind; smellblind; voltage gated sodium ion channel; voltage-sensitive sodium channel", "tax_id": 7227, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); familial atrial fibrillation (Disease Ontology:DOID:0050650); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); autism spectrum disorder (Disease Ontology:DOID:0060041); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); episodic ataxia type 9 (Disease Ontology:DOID:0060965); hereditary sensory and autonomic neuropathy type 7 (Disease Ontology:DOID:0070149); developmental and epileptic encephalopathy 6B (Disease Ontology:DOID:0070379); developmental and epileptic encephalopathy 62 (Disease Ontology:DOID:0080420); developmental and epileptic encephalopathy 11 (Disease Ontology:DOID:0080421); Dravet syndrome (Disease Ontology:DOID:0080422); developmental and epileptic encephalopathy 13 (Disease Ontology:DOID:0080445); benign familial infantile seizures 3 (Disease Ontology:DOID:0081116); benign familial infantile seizures 5 (Disease Ontology:DOID:0081118); congenital myopathy 22A (Disease Ontology:DOID:0081354); congenital myopathy 22B (Disease Ontology:DOID:0081355); familial focal epilepsy with variable foci 4 (Disease Ontology:DOID:0081424); Brugada syndrome 1 (Disease Ontology:DOID:0110218); dilated cardiomyopathy 1E (Disease Ontology:DOID:0110433); long QT syndrome 3 (Disease Ontology:DOID:0110646); congenital myasthenic syndrome 16 (Disease Ontology:DOID:0110682); progressive familial heart block type IA (Disease Ontology:DOID:0111074); familial hemiplegic migraine 3 (Disease Ontology:DOID:0111183); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); paroxysmal extreme pain disorder (Disease Ontology:DOID:0111537); paramyotonia congenita of Von Eulenburg (Disease Ontology:DOID:0111538); familial episodic pain syndrome 2 (Disease Ontology:DOID:0111730); familial episodic pain syndrome 3 (Disease Ontology:DOID:0111731); sciatic neuropathy (Disease Ontology:DOID:11446); sick sinus syndrome (Disease Ontology:DOID:13884); hyperkalemic periodic paralysis (Disease Ontology:DOID:14451); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); brain ischemia (Disease Ontology:DOID:2316); long QT syndrome (Disease Ontology:DOID:2843); brain infarction (Disease Ontology:DOID:3454); congestive heart failure (Disease Ontology:DOID:6000); sudden infant death syndrome (Disease Ontology:DOID:9007); erythromelalgia (Disease Ontology:DOID:9240)", "pathway": " (dme:Dmel_CG9907)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;10880477;10966106;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2538830;2550145;25589440;26109356;26109357;8182428;8536968", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O15994;P92137;Q0KHR8;Q0KHR9;Q24082;Q24083;Q24084;Q24528;Q24529;Q24530;Q24531;Q24532;Q9VXF7", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005272 sodium channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001518 voltage-gated sodium channel complex;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0019228 neuronal action potential;GO:0001666 response to hypoxia;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P35500-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25159-1", "uniprot_id": "STAU_DROME", "mass": 110283.0, "length": 1026, "protein_name": "Maternal effect protein staufen", "gene_name": "stau", "organism": "Fruit fly", "refseq_name": "staufen, isoform C", "refseq_ac": "NP_001163185", "gene_names_uniprotkb": "stau; CG5753; Dmel\\CG5753; Dmel_CG5753; Dmstau; STAU; Stau1; Staufen; Stauf; Stau; dStau", "gene_names_refseq": "CG5753; Dmel\\CG5753; Dmstau; STAU; Stau1; Staufen; Stauf; Stau; dStau; stau", "protein_names_uniprotkb": "Maternal effect protein staufen", "protein_names_refseq": "CG5753-PC; stau-PC; staufen, isoform C; staufen; stauffen", "tax_id": 7227, "disease": "microphthalmia (Disease Ontology:DOID:10629); atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (dme:Dmel_CG5753)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10698941;10716936;10731132;12537568;12537572;12537573;12537574;16110336;1712672;17178403;17569856;17569867;18327897;25589440;26109356;26109357;40245499;7628456;8001156", "class_list": "", "function": "RNA-binding protein which forms ribonucleoprotein complexes (RNPs) that play critical roles in the localization, translational repression and turnover of RNAs during embryogenesis, neurotransmission and neurogenesis (PubMed:10698941, PubMed:1712672, PubMed:17178403, PubMed:8001156). In the oocyte, essential for the localization of both the osk/oskar mRNA to the posterior pole and bcd/bicoid RNA to the anterior pole, and is therefore required for the correct anterior-posterior patterning of the developing embryo (PubMed:10698941, PubMed:1712672, PubMed:8001156). Association with osk or bcd at their respective poles, appears to promote the formation and stabilization of the ribonucleoprotein complexes (PubMed:1712672, PubMed:8001156). Integral component of diverse neuritic ribonucleoprotein complexes (RNPs) that mediate the transport, translation and turnover of neuronal RNAs during neuorgenesis and the translation repression of synaptic transcripts in preparation for their dendritic targeting (PubMed:17178403)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6NQY8;Q86PB7;Q9V8B8;Q9V8B9", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003725 double-stranded RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0106222 lncRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007281 germ cell development;GO:0007616 long-term memory;GO:0045887 positive regulation of synaptic assembly at neuromuscular junction;GO:0007400 neuroblast fate determination;GO:0033962 P-body assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P25159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KRI2-1", "uniprot_id": "LOLAL_DROME", "mass": 14489.0, "length": 127, "protein_name": "Longitudinals lacking protein-like", "gene_name": "lolal", "organism": "Fruit fly", "refseq_name": "lola like, isoform E", "refseq_ac": "NP_001163186", "gene_names_uniprotkb": "lolal; 12; Ban; CG5738; Dmel\\CG5738; Dmel_CG5738; EP0647; EP647; LOLAL; Lolal; anon-EST:fe3D3; anon-WO0172774.186; ban; bat; l(2)k02512; l(2)kO2512", "gene_names_refseq": "25/12; Ban; CG5738; Dmel\\CG5738; EP0647; EP647; LOLAL; Lolal; anon-EST:fe3D3; anon-WO0172774.186; ban; bat; l(2)k02512; l(2)kO2512; lolal", "protein_names_uniprotkb": "Longitudinals lacking protein-like; Lola-like protein; Protein Batman", "protein_names_refseq": "CG5738-PE; anon-fast-evolving-3D3; batman; lola like, isoform E; lola like; lola-like; lolal-PE", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5738)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;11370860;12537568;12537569;12537572;12537573;12537574;12556479;12834867;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Required, together with Trl, for maintaining the repressed state of target genes including homeotic genes Scr and Ubx. May also be involved in the activation of homeotic genes. Binds to a DNA Polycomb response element (PRE) at the bithorax complex. Also binds to polytene chromosomes at several hundred sites, many of which are shared with Trl and ph-p. Required during embryonic development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZN1;B7YZR8;C7LAH2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0031519 PcG protein complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7KRI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K3B9-1", "uniprot_id": "MET16_DROME", "mass": 35146.0, "length": 305, "protein_name": "U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase", "gene_name": "Dmel\\CG7544", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001163156", "gene_names_uniprotkb": "Dmel\\CG7544; CG7544; Dmel_CG7544; METTL16", "gene_names_refseq": "CG7544; Dmel\\CG7544; METTL16", "protein_names_uniprotkb": "U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; 2.1.1.346", "protein_names_refseq": "CG7544-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7544)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.-;2.1.1.346", "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003676 nucleic acid binding;GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity;GO:0120048 U6 snRNA (adenine-(43)-N(6))-methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0070475 rRNA base methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7K3B9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K0L4-1", "uniprot_id": "WDR26_DROME", "mass": 69617.0, "length": 630, "protein_name": "WD repeat-containing protein 26 homolog", "gene_name": "Dmel\\CG7611", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform I", "refseq_ac": "NP_001163489", "gene_names_uniprotkb": "Dmel\\CG7611; CG7611; Dmel_CG7611; WDR26", "gene_names_refseq": "CG7611; Dmel\\CG7611; WDR26", "protein_names_uniprotkb": "WD repeat-containing protein 26 homolog", "protein_names_refseq": "CG7611-PI; uncharacterized protein, isoform I", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7611); (R-DME-9861718)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17041588;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "G-beta-like protein involved in cell signal transduction (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V292", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0034657 GID complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7K0L4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98081-1", "uniprot_id": "DAB_DROME", "mass": 243072.0, "length": 2224, "protein_name": "Protein disabled", "gene_name": "Dab", "organism": "Fruit fly", "refseq_name": "disabled, isoform A", "refseq_ac": "NP_524119", "gene_names_uniprotkb": "Dab; CG9695; Dmel\\CG9695; Dmel_CG9695; cDNA C; dab", "gene_names_refseq": "CG9695; Dab; Dmel\\CG9695; cDNA C; dab", "protein_names_uniprotkb": "Protein disabled", "protein_names_refseq": "CG9695-PA; Dab-PA; disabled, isoform A; disabled", "tax_id": 7227, "disease": "spinocerebellar ataxia 37 (Disease Ontology:DOID:0050984); autistic disorder (Disease Ontology:DOID:12849); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (dme:Dmel_CG9695)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;33925313;7680635;9671493", "class_list": "", "function": "Together with Abl, involved in embryonic neural development. May have a role in eye development. Acts as an adapter protein for SH2-domain containing proteins during sevenless (sev) signaling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9VV93", "ec_number_list": "", "go_molecular_function": "GO:0005118 sevenless binding;GO:0017124 SH3 domain binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0098793 presynapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0072583 clathrin-dependent endocytosis;GO:0008045 motor neuron axon guidance;GO:0048488 synaptic vesicle endocytosis;GO:0007349 cellularization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P98081-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31409-1", "uniprot_id": "VATB_DROME", "mass": 54549.0, "length": 490, "protein_name": "V-type proton ATPase subunit B", "gene_name": "Vha55", "organism": "Fruit fly", "refseq_name": "vacuolar H[+]-ATPase 55kD subunit, isoform C", "refseq_ac": "NP_001163597", "gene_names_uniprotkb": "Vha55; 13; ATP6V1B1; CG17369; Dmel\\CG17369; Dmel_CG17369; SzA; V-ATPase; V-type H+-ATPase; VAT-2; VA; l(3)87Ca; l(3)SzA; l(3)j2E9; v-ATPase; vha55", "gene_names_refseq": "1208/13; ATP6V1B1; CG17369; Dmel\\CG17369; SzA; V-ATPase; V-type H+-ATPase; VAT-2; VA; Vha55; l(3)87Ca; l(3)SzA; l(3)j2E9; v-ATPase; vha55", "protein_names_uniprotkb": "V-type proton ATPase subunit B; V-ATPase 55 kDa subunit; V-ATPase subunit B; Vacuolar proton pump subunit B", "protein_names_refseq": "B subunit of V-ATPase; CG17369-PC; V-ATPase B-subunit; V-ATPase subunit B; V1 B subunit; Vha55-PC; vacuolar ATP synthase subunit B; vacuolar ATPase B subunit; vacuolar H+-ATPase 55kD B subunit; vacuolar H+ATPase subunit B; vacuolar H[+]-ATPase 55-kDa B subunit; vacuolar H[+]-ATPase 55kD B subunit; vacuolar H[+]-ATPase 55kD subunit, isoform C", "tax_id": 7227, "disease": "enlarged vestibular aqueduct (Disease Ontology:DOID:0050332); autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); follicular lymphoma (Disease Ontology:DOID:0050873); autosomal dominant congenital deafness with onychodystrophy (Disease Ontology:DOID:0080720); renal tubular acidosis (Disease Ontology:DOID:14219); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG17369); (R-DME-1222556); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;20579879;25589440;26109356;26109357;8940044", "class_list": "", "function": "Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential for the proper assembly and activity of V-ATPase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YH8;Q9VG52", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P31409-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24572-1", "uniprot_id": "CAF1_DROME", "mass": 48635.0, "length": 430, "protein_name": "Chromatin assembly factor 1 p55 subunit", "gene_name": "Caf1-55", "organism": "Fruit fly", "refseq_name": "chromatin assembly factor 1, p55 subunit, isoform A", "refseq_ac": "NP_524354", "gene_names_uniprotkb": "Caf1-55; 154659_at; 48; 55; CAF-1 p55; CAF-1; CAF1-55; CAF1-p55; CAF1p55; CAF1; CG4236; Caf-1; Caf1 (p55); Caf1-p55; Caf1p55; Caf1; Dmel\\CG4236; Dmel_CG4236; LIN-53; NURF 55; NURF-55; NURF55; NURF; Nurf 55; Nurf-55; Nurf55; Nurf; P55; RBAP48; RbAp48; S(ls)3; caf-1; caf1 p55; caf1-55; caf1; d-CAF1; dCAF-1 p55; dCAF-1-p55; dCAF-1; dCAF1-p55; dCAF1; dNURF; dp55; nurf55; p55 CAF1; p55CAF1; p55", "gene_names_refseq": "154659_at; 55; CAF-1 p55; CAF-1; CAF1-55; CAF1-p55; CAF1p55; CAF1; CG4236; Caf-1; Caf1 (p55); Caf1-55; Caf1-p55; Caf1/p55; Caf1p55; Caf1; Dmel\\CG4236; MSI1/RbAp48/CAC3/LIN-53; NURF 55; NURF-55; NURF55; NURF; Nurf 55; Nurf-55; Nurf55; Nurf; P55; RBAP48; RbAp46/48; RbAp48; S(ls)3; caf-1; caf1 p55; caf1-55; caf1; d-CAF1; dCAF-1 p55; dCAF-1-p55; dCAF-1; dCAF1-p55; dCAF1; dNURF; dp55; nurf55; p55 CAF1; p55/NURF-55; p55CAF1; p55", "protein_names_uniprotkb": "Chromatin assembly factor 1 p55 subunit; CAF-1 p55 subunit; CAF-1; NURF-55; Nucleosome-remodeling factor 55 kDa subunit", "protein_names_refseq": "CG4236-PA; Caf1-55-PA; Nurf55/CAF1; chromatin assembly Factor-1; chromatin assembly factor 1 subunit; chromatin assembly factor 1, p55 subunit, isoform A; chromatin associated factor-1 subunit; nucleosome remodeling factor - 55kD; p55", "tax_id": 7227, "disease": "X-linked spermatogenic failure 9 (Disease Ontology:DOID:0061177); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (dme:Dmel_CG4236); (R-DME-1538133); (R-DME-212300); (R-DME-2559580); (R-DME-3214815); (R-DME-3214847); (R-DME-6804758); (R-DME-8943724); (R-DME-8951664); (R-DME-8953750); (R-DME-9764725); (R-DME-9909649); (R-DME-9937850); (R-DME-9940951)", "pathway_count": 14, "publication_count": 32, "publication_id_list": "10731132;11124122;11533245;12408863;12408864;12490953;12533794;12537568;12537569;12537572;12537573;12537574;12697833;15456884;15479636;15516265;15545624;16110336;16951084;17372656;17569856;17569867;18327897;22354997;25589440;26109356;26109357;8524837;8622682;8887645;9419341;9784495", "class_list": "", "function": "Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AP04;Q9VFB4", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0000976 transcription cis-regulatory region binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0035098 ESC/E(Z) complex;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0034728 nucleosome organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q24572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KSD8-1", "uniprot_id": "TAD2A_DROME", "mass": 65625.0, "length": 562, "protein_name": "Transcriptional adapter 2A", "gene_name": "Ada2a", "organism": "Fruit fly", "refseq_name": "transcriptional adaptor 2a, isoform E", "refseq_ac": "NP_001014634", "gene_names_uniprotkb": "Ada2a; ADA2a; Ada2A; CG31318; CG33520; CG43663; CG7150; DmADA2a; DmAda2a; Dmel\\CG43663; Dmel_CG43663; Rpb4; ada2a; dADA2a; dAda2A; dAda2a", "gene_names_refseq": "ADA2a; Ada2A; Ada2a; CG31318; CG33520; CG43663; CG7150; DmADA2a; DmAda2a; Dmel\\CG43663; ada2a; dADA2a; dAda2A; dAda2a", "protein_names_uniprotkb": "Transcriptional adapter 2A; dADA2a", "protein_names_refseq": "Ada2a-PE; CG43663-PE; transcriptional adaptor 2a, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43663)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12482983;12537568;12537572;12537573;12537574;12697829;16110336;16135810;17569856;17569867;18327268;19921261;22796493;25589440;26109356;26109357", "class_list": "", "function": "Component of the histone acetyltransferase (HAT) complex ATAC; predominantly involved in acetylation of histone H4, including at Lys-6 (H4K5ac) and Lys-13 (H4K12ac) (PubMed:12482983, PubMed:12697829, PubMed:22796493). May be part of several different complexes, including Gcn5-independent complexes involved in RNA polymerase II-dependent transcription (PubMed:12697829)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V6Z0;Q59DW3;Q59DW4;Q8I8U8;Q8I9F2;Q8I9F3;Q8IN85", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005634 nucleus;GO:0000791 euchromatin;GO:0140672 ATAC complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q7KSD8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23573-1", "uniprot_id": "CDK2_DROME", "mass": 35888.0, "length": 314, "protein_name": "Cyclin-dependent kinase 2", "gene_name": "Cdk2", "organism": "Fruit fly", "refseq_name": "Cyclin-dependent kinase 2, isoform C", "refseq_ac": "NP_001163666", "gene_names_uniprotkb": "Cdk2; CDC2C; CDC2c; CDK2; CG10498; Cdc2c; Dcdc2c; DmCdc2c; DmCdk2; Dmcdc2c; Dmel\\CG10498; Dmel_CG10498; S(Sev-CycE)3A; cdc2c; cdk2; dCdk2", "gene_names_refseq": "CDC2C; CDC2c; CDK2/CDC2c; CDK2; CG10498; Cdc2c; Cdk2; Dcdc2c; DmCdc2c; DmCdk2; Dmcdc2c; Dmel\\CG10498; S(Sev-CycE)3A; cdc2c; cdk2; dCdk2", "protein_names_uniprotkb": "Cyclin-dependent kinase 2; 2.7.11.22; 2.7.11.23; Cell division control protein 2 cognate", "protein_names_refseq": "CG10498-PC; Cdk2-PC; Cyclin-dependent kinase 2, isoform C; cdc2c; cyclin E; cyclin-dependent kinase 2", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283); interstitial cystitis (Disease Ontology:DOID:13949); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (dme:Dmel_CG10498); (R-DME-1538133); (R-DME-176187); (R-DME-176408); (R-DME-187577); (R-DME-2559582); (R-DME-2559586); (R-DME-5693607); (R-DME-6804116); (R-DME-6804756); (R-DME-68911); (R-DME-68949); (R-DME-68962); (R-DME-69017); (R-DME-69200); (R-DME-69202); (R-DME-69231); (R-DME-69563); (R-DME-69656); (R-DME-9616222)", "pathway_count": 20, "publication_count": 17, "publication_id_list": "10731132;10790398;12537568;12537569;12537572;12537573;12537574;1378625;16110336;17569856;17569867;18327897;2120045;21311225;25589440;26109356;26109357", "class_list": "", "function": "Like Cdk1, could play a key role in the control of the eukaryotic cell cycle., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KI40;Q9TXB2;Q9VDJ4", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;5.6.1.8;2.7.11.11;3.1.3.48;2.7.11.23;2.3.2.23;2.7.7.7;3.1.11.-;2.7.12.1;3.6.4.12;2.7.10.2;2.7.11.25;2.7.11.12;2.7.12.2;2.7.7.-;2.3.1.48;3.4.19.-;5.6.1.5;5.6.2.4;2.3.2.24;2.7.11.39;3.6.-.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0007165 signal transduction;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P23573-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O97067-1", "uniprot_id": "PTH2_DROME", "mass": 19873.0, "length": 186, "protein_name": "Probable peptidyl-tRNA hydrolase 2", "gene_name": "Dmel\\CG1307", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": "NP_001287202", "gene_names_uniprotkb": "Dmel\\CG1307; BG:DS00004.12; CG1307; Dmel_CG1307", "gene_names_refseq": "BG:DS00004.12; CG1307; Dmel\\CG1307", "protein_names_uniprotkb": "Probable peptidyl-tRNA hydrolase 2; 3.1.1.29; PTH 2", "protein_names_refseq": "CG1307-PE; hypothetical 23.1kd-like protein; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1307); (R-DME-5689880)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MR09;Q9VI42", "ec_number_list": "3.1.1.29;3.4.24.56;3.6.5.-;2.3.2.27;3.4.19.12", "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O97067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27398-1", "uniprot_id": "CAND_DROME", "mass": 174313.0, "length": 1594, "protein_name": "Calpain-D", "gene_name": "sol", "organism": "Fruit fly", "refseq_name": "small optic lobes, isoform A", "refseq_ac": "NP_476737", "gene_names_uniprotkb": "sol; CG1391; CalpD; DmSol; Dmel\\CG1391; Dmel_CG1391; PC79; SOL; Sol; calp D; calpD; nofE; w5000", "gene_names_refseq": "CG1391; CalpD; DmSol; Dmel\\CG1391; PC79; SOL; Sol; calp D; calpD; nofE; sol; w5000", "protein_names_uniprotkb": "Calpain-D; 3.4.22.-; CANP D; Calcium-activated neutral proteinase D; Small optic lobes protein", "protein_names_refseq": "CG1391-PA; small optic lobes, isoform A; small optic lobe; sol-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1391)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;1714593;17569856;17569867;18327897;25589440;26109356;26109357;9144213", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB]; Has a role in eye development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O61346;Q7KU57;Q7KU58;Q8MQP3;Q9VRH3;Q9VRH4", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0007399 nervous system development;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P27398-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30432-1", "uniprot_id": "FUR2_DROME", "mass": 183370.0, "length": 1679, "protein_name": "Furin-like protease 2", "gene_name": "Fur2", "organism": "Fruit fly", "refseq_name": "furin 2, isoform D", "refseq_ac": "NP_523368", "gene_names_uniprotkb": "Fur2; 154521_at; CG18734; CG4235; DMH#11; Dfur2; Dfurin2; Dmel\\CG18734; Dmel_CG18734; FUR2; Furin; fur2; furin", "gene_names_refseq": "154521_at; CG18734; CG4235; DMH#11; Dfur2; Dfurin2; Dmel\\CG18734; FUR2; Fur2; Furin; fur2; furin", "protein_names_uniprotkb": "Furin-like protease 2; 3.4.21.75; Furin-2", "protein_names_refseq": "CG18734-PD; Dfurin2; Fur2-PD; Furin-like protease; furin 2, isoform D; furin 2; furin2", "tax_id": 7227, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); sciatic neuropathy (Disease Ontology:DOID:11446); VACTERL association (Disease Ontology:DOID:14679); colon adenocarcinoma (Disease Ontology:DOID:234); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dme:Dmel_CG18734)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1512259;16110336;17569856;17569867;25589440;26109356;26109357;7880443", "class_list": "", "function": "Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "A4V4M0;A4V4M2;Q24301;Q5BI10;Q8SZS2", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network;GO:0016020 membrane", "go_biological_process": "GO:0016485 protein processing;GO:0051048 negative regulation of secretion;GO:0045464 R8 cell fate specification;GO:0006508 proteolysis;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P30432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48149-1", "uniprot_id": "RS15A_DROME", "mass": 14771.0, "length": 130, "protein_name": "Small ribosomal subunit protein uS8A", "gene_name": "RpS15Aa", "organism": "Fruit fly", "refseq_name": "ribosomal protein S15Aa, isoform F", "refseq_ac": "NP_001162738", "gene_names_uniprotkb": "RpS15Aa; CG2033; Dmel\\CG2033; Dmel_CG2033; Rp S15 Aa; RpS15A; RpS15a; S15Aa; S15; S8; anon-EST:Posey44", "gene_names_refseq": "CG2033; Dmel\\CG2033; Rp S15 Aa; RpS15Aa; RpS15A; RpS15a; S15Aa; S15; S8; anon-EST:Posey44", "protein_names_uniprotkb": "Small ribosomal subunit protein uS8A; 40S ribosomal protein S15Aa", "protein_names_refseq": "CG2033-PF; RpS15Aa-PF; ribosomal protein S15Aa, isoform F; ribosomal protein S15A", "tax_id": 7227, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 20 (Disease Ontology:DOID:0111891)", "pathway": " (dme:Dmel_CG2033); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357;8182070", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4D9;Q9VYE4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P48149-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35128-1", "uniprot_id": "UBE2N_DROME", "mass": 17236.0, "length": 151, "protein_name": "Ubiquitin-conjugating enzyme E2 N", "gene_name": "ben", "organism": "Fruit fly", "refseq_name": "bendless, isoform B", "refseq_ac": "NP_001162752", "gene_names_uniprotkb": "ben; BEN; Bendless; Bend; Ben; CG18319; Dmel\\CG18319; Dmel_CG18319; UBC13; Ubc13; UbcD3; anon-WO03040301.242; bend; nj-262; ubc13", "gene_names_refseq": "BEN; Bendless; Bend; Ben; CG18319; Dmel\\CG18319; UBC13; Ubc13; UbcD3; anon-WO03040301.242; bend; ben; nj-262; ubc13", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 N; 2.3.2.23; E2 ubiquitin-conjugating enzyme N; Protein bendless; Ubiquitin carrier protein N; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase D3; Ubiquitin-protein ligase N", "protein_names_refseq": "CG18319-PB; ben-PB; bendless, isoform B; bendless; nonjumper-262", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18319); (R-DME-209447); (R-DME-214399); (R-DME-445989); (R-DME-5205685); (R-DME-9020702); (R-DME-937039); (R-DME-9646399); (R-DME-975144); (R-DME-983168)", "pathway_count": 10, "publication_count": 22, "publication_id_list": "10731132;11018014;12537568;12537569;12537572;12537573;12537574;12732719;14519762;16081424;16110336;16311020;16894030;17158449;17569856;17569867;17989248;25589440;26109356;26109357;8182464;8394720", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9YHJ7;Q9VY67", "ec_number_list": "2.3.2.27;2.3.2.25;2.3.2.23;3.6.5.-;2.3.2.31;2.7.11.1;2.7.12.2;2.7.11.25;6.2.1.64;2.3.2.26;3.4.19.12;2.7.11.10;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0031624 ubiquitin conjugating enzyme binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0031372 UBC13-MMS2 complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007409 axonogenesis;GO:0046330 positive regulation of JNK cascade;GO:0051124 synaptic assembly at neuromuscular junction;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P35128-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K4Q5-1", "uniprot_id": "Y0417_DROME", "mass": 72370.0, "length": 662, "protein_name": "Probable protein phosphatase CG10417", "gene_name": "PP2Cg", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": "NP_610169", "gene_names_uniprotkb": "PP2Cg; CG10417; Dmel\\CG10417; Dmel_CG10417", "gene_names_refseq": "CG10417; Dmel\\CG10417; PP2Cg", "protein_names_uniprotkb": "Probable protein phosphatase CG10417; 3.1.3.16", "protein_names_refseq": "CG10417-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG10417)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15952742;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357;40245499", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.27;3.1.3.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q7K4Q5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K480-1", "uniprot_id": "MEPCE_DROME", "mass": 146234.0, "length": 1367, "protein_name": "7SK snRNA methylphosphate capping enzyme bin3", "gene_name": "bin3", "organism": "Fruit fly", "refseq_name": "bicoid-interacting protein 3, isoform C", "refseq_ac": "NP_001260724", "gene_names_uniprotkb": "bin3; Bin3; CG8276; Dmel\\CG8276; Dmel_CG8276; l(2)SH1014; l(2)SH2 1014", "gene_names_refseq": "Bin3; CG8276; Dmel\\CG8276; bin3; l(2)SH1014; l(2)SH2 1014", "protein_names_uniprotkb": "7SK snRNA methylphosphate capping enzyme bin3; 2.1.1.-; Bicoid-interacting protein 3", "protein_names_refseq": "Bicoid-interacting protein 3; CG8276-PC; bicoid interacting protein 3; bicoid-interacting protein 3, isoform C; bin3-PC; lethal (2) SH1014", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8276)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10717484;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;21262214;25589440;26109356;26109357;38100593", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it (By similarity). Required for SK7, but not U6 snRNA stability (PubMed:38100593). Required for dorso-ventral patterning in oogenesis and for anterior-posterior pattern formation during embryogenesis, possibly by binding and stabilizing 7SK RNA, thereby promoting formation of a repressive RNA-protein complex (PubMed:21262214)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q86LF5;Q9NJV6", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0008168 methyltransferase activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0008171 O-methyltransferase activity;GO:0017069 snRNA binding;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0032502 developmental process;GO:0017148 negative regulation of translation;GO:0032259 methylation;GO:0034244 negative regulation of transcription elongation by RNA polymerase II;GO:0040031 snRNA modification", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7K480-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6NLL1-1", "uniprot_id": "Y1411_DROME", "mass": 79070.0, "length": 710, "protein_name": "WD repeat-containing protein CG11141", "gene_name": "Dmel\\CG11141", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": "NP_001286159", "gene_names_uniprotkb": "Dmel\\CG11141; CG11141; Dmel_CG11141", "gene_names_refseq": "CG11141; Dmel\\CG11141", "protein_names_uniprotkb": "WD repeat-containing protein CG11141", "protein_names_refseq": "CG11141-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "hereditary sensory and autonomic neuropathy type 9 (Disease Ontology:DOID:0110801)", "pathway": " (dme:Dmel_CG11141)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NMV3;Q960Z3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032527 protein exit from endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6NLL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K4B6-1", "uniprot_id": "TMTC3_DROME", "mass": 105361.0, "length": 926, "protein_name": "Protein O-mannosyl-transferase Tmtc3", "gene_name": "Tmtc3", "organism": "Fruit fly", "refseq_name": "transmembrane O-mannosyltransferase targeting cadherins 3, isoform A", "refseq_ac": "NP_477246", "gene_names_uniprotkb": "Tmtc3; CG4050; Dmel\\CG4050; Dmel_CG4050; TMTC3; anon-DM192; anon-j", "gene_names_refseq": "CG4050; Dmel\\CG4050; TMTC3; Tmtc3; anon-DM192; anon-j", "protein_names_uniprotkb": "Protein O-mannosyl-transferase Tmtc3; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 3; Transmembrane and tetratricopeptide repeat-containing 3", "protein_names_refseq": "CG4050-PA; Tmtc3-PA; transmembrane O-mannosyltransferase targeting cadherins 3, isoform A; transmembrane and tetratricopeptide repeat containing 3", "tax_id": 7227, "disease": "lissencephaly 8 (Disease Ontology:DOID:0112233); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG4050)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O02435;Q24581", "ec_number_list": "2.4.1.109", "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose;GO:0060255 regulation of macromolecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7K4B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24009-1", "uniprot_id": "BICC_DROME", "mass": 97849.0, "length": 905, "protein_name": "Protein bicaudal C", "gene_name": "BicC", "organism": "Fruit fly", "refseq_name": "bicaudal C, isoform A", "refseq_ac": "NP_476865", "gene_names_uniprotkb": "BicC; BG:DS00913.2; BICC; Bic-C; CG4824; Dmel\\CG4824; Dmel_CG4824; bicC; br34; l(2)br34", "gene_names_refseq": "BG:DS00913.2; BICC; Bic-C; BicC; CG4824; Dmel\\CG4824; Dromel_CG4824_FBtr0080804_bicc_mORF; bicC; br34; l(2)br34", "protein_names_uniprotkb": "Protein bicaudal C", "protein_names_refseq": "BicC-PA; Bicaudal-C; CG4824-PA; bicaudal C, isoform A", "tax_id": 7227, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); cystic renal dysplasia (Disease Ontology:DOID:0111682); cystic kidney disease (Disease Ontology:DOID:2975); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (dme:Dmel_CG4824)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;7538070;9671494", "class_list": "", "function": "RNA-binding protein that is involved in oogenesis. Required for correct targeting of the migrating anterior follicle cells and the establishment of anterior-posterior polarity in the oocyte. May act as translational repressor of oskar during oogenesis. Function seems to be sensitive to small changes in expression., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IP26", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030036 actin cytoskeleton organization;GO:0000226 microtubule cytoskeleton organization;GO:0048477 oogenesis;GO:0007297 follicle cell of egg chamber migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q24009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40945-1", "uniprot_id": "ARF4_DROME", "mass": 20617.0, "length": 180, "protein_name": "ADP ribosylation factor 4", "gene_name": "Arf4", "organism": "Fruit fly", "refseq_name": "ADP ribosylation factor 4, isoform B", "refseq_ac": "NP_001259087", "gene_names_uniprotkb": "Arf4; ARF2; ARFII; Arf102E; Arf102F; Arf2; Arf5; CG11027; CG1102; Dmel\\CG11027; Dmel_CG11027; P40945; arf102F; arf4; dARFII", "gene_names_refseq": "ARF2; ARFII; Arf102E; Arf102F; Arf2; Arf4; Arf5; CG11027; CG1102; Dmel\\CG11027; P40945; arf102F; arf4; dARFII", "protein_names_uniprotkb": "ADP ribosylation factor 4; dARF II", "protein_names_refseq": "ADP ribosylation factor 102F; ADP ribosylation factor 4, isoform B; ADP ribosylation factor II; ADP ribosylation factor at 102F; Arf4-PB; CG11027-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11027); (R-DME-5620916); (R-DME-6807878); (R-DME-6811434)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8063793", "class_list": "", "function": "GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB, PubMed]; GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V499", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008047 enzyme activator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0048731 system development;GO:0006886 intracellular protein transport;GO:0046718 symbiont entry into host cell;GO:0016192 vesicle-mediated transport;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40945-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36179-1", "uniprot_id": "2AAA_DROME", "mass": 65424.0, "length": 591, "protein_name": "Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit", "gene_name": "Pp2A-29B", "organism": "Fruit fly", "refseq_name": "protein phosphatase 2A at 29B, isoform C", "refseq_ac": "NP_001027225", "gene_names_uniprotkb": "Pp2A-29B; 29B; CG13383; CG17291; CG33297; DPR65; Dmel\\CG17291; Dmel_CG17291; PP2A 29B; PP2A A; PP2A at 29B; PP2A-29B; PP2A-A; PP2A[A]; PP2A; PR65; Pp2A29B; Pp2A; dPP2A A; dPP2A; pp2A-29B; pp2a-29b", "gene_names_refseq": "29B; A/PR65; CG13383; CG17291; CG33297; DPR65; Dmel\\CG17291; PP2A 29B; PP2A A; PP2A at 29B; PP2A-29B; PP2A-A; PP2A[A]; PP2A; PR65; Pp2A-29B; Pp2A29B; Pp2A; dPP2A A; dPP2A; pp2A-29B; pp2a-29b", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit; PR65; Protein phosphatase PP2A regulatory subunit A", "protein_names_refseq": "65 kDa regulatory subunit of protein phosphatase; CG17291-PC; PP2A 65kD subunit A; Pp2A-29B-PC; protein phosphatase 2A at 29B, isoform C; protein phosphatase 2A at 29B; protein phosphatase 2A; protein phosphate 2A; regulatory subunit A of type 2A protein phosphatase", "tax_id": 7227, "disease": "autosomal dominant intellectual developmental disorder 36 (Disease Ontology:DOID:0070066); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (dme:Dmel_CG17291); (R-DME-113501); (R-DME-1295596); (R-DME-195253); (R-DME-196299); (R-DME-209155); (R-DME-209190); (R-DME-209214); (R-DME-209360); (R-DME-209396); (R-DME-209413); (R-DME-209440); (R-DME-209461); (R-DME-2995383); (R-DME-389513); (R-DME-432553); (R-DME-432620); (R-DME-432626); (R-DME-5673000); (R-DME-5675221); (R-DME-6811558); (R-DME-69231); (R-DME-69273); (R-DME-975957); (R-DME-9833482); (R-DME-9860927)", "pathway_count": 26, "publication_count": 83, "publication_id_list": "10073940;10102270;10196136;10409506;10421629;10457025;10458606;10477300;10557210;10731132;10838083;10846164;11336703;11430804;11440719;11912487;11927557;11955435;11955436;12000790;12122057;12231619;12432393;12442174;12447397;12537568;12537572;12537573;12537574;12563262;12636921;12663920;12781135;12944510;1320961;14636582;14731402;14759367;14966281;14980226;15300262;15459103;15563523;15592457;15598741;15616566;15875013;16041759;16110336;16139204;16299518;16319317;16326393;16386907;16410523;16543224;16603629;16630821;17077139;17418796;17569856;17569867;17575052;17925225;18593878;18815259;25589440;26109356;26109357;32966759;37995689;39032490;7481773;8596938;8600384;8898207;8906787;8906794;8938123;8990193;9215627;9482888;9674431", "class_list": "", "function": "The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (By similarity). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:32966759). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for mts/PP2A, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and Spt5, thereby preventing transcriptional elongation (PubMed:32966759)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0F7;Q2MGK6;Q5BI19;Q9VLN3", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035330 regulation of hippo signaling;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 8.4, "record_id": "P36179-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35122-1", "uniprot_id": "UCHL_DROME", "mass": 25850.0, "length": 227, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "Uch", "organism": "Fruit fly", "refseq_name": "ubiquitin carboxy-terminal hydrolase, isoform B", "refseq_ac": "NP_001188681", "gene_names_uniprotkb": "Uch; CG4265; Dmel\\CG4265; Dmel_CG4265; P35122; UBL; UCH-D19; UCH-D; UCH-L1; UCHL1; UCH; Uch-D; Uchl1; Uchl; cg4265; dUCH; dUch; ubc-D; uch-D; uch", "gene_names_refseq": "CG4265; Dmel\\CG4265; P35122; UBL; UCH-D19; UCH-D; UCH-L1; UCHL1; UCH; Uch-D; Uchl1; Uchl; Uch; cg4265; dUCH; dUch; uch-D; uch", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12; Ubiquitin thioesterase", "protein_names_refseq": "CG4265-PB; Uch-PB; ubiquitin C-terminal hydrolase; ubiquitin carboxy-terminal hydrolase, isoform B; ubiquitin carboxyl terminal hydrolase; ubiquitin carboxyterminal hydrolase", "tax_id": 7227, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); hereditary spastic paraplegia 79A (Disease Ontology:DOID:0070455); hereditary spastic paraplegia 79B (Disease Ontology:DOID:0112344); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); retinal disease (Disease Ontology:DOID:5679); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG4265); (R-DME-5689603); (R-DME-8866652); (R-DME-8951664)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;10731138;12537568;12537572;12537573;12537574;1426603;16110336;17569856;17569867;25589440;26109356;26109357;7683284", "class_list": "", "function": "Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4PIX7;Q9TWA0;Q9V417", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045821 positive regulation of glycolytic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P35122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11929-1", "uniprot_id": "NINL_DROME", "mass": 122903.0, "length": 1091, "protein_name": "Ninein homolog", "gene_name": "Nin", "organism": "Fruit fly", "refseq_name": "ninein, isoform H", "refseq_ac": "NP_476916", "gene_names_uniprotkb": "Nin; Bsg25D; CG14025; Dmel\\CG14025; Dmel_CG14025; brg25D; bsg25D; bsq25D; nin", "gene_names_refseq": "Bsg25D; CG14025; Dmel\\CG14025; Nin; brg25D; bsg25D; bsq25D; nin", "protein_names_uniprotkb": "Ninein homolog; Blastoderm-specific protein 25D", "protein_names_refseq": "Blastoderm-specific gene 25D; CG14025-PH; Nin-PH; ninein, isoform H; ninein", "tax_id": 7227, "disease": "Seckel syndrome 7 (Disease Ontology:DOID:0070011)", "pathway": " (dme:Dmel_CG14025)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;27053665;27422905;30626718;3104878;32066907", "class_list": "", "function": "Required for the positioning and anchorage of the microtubule minus-ends in various cells (PubMed:27422905, PubMed:30626718, PubMed:32066907). In fat body cells, part of perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) which function to accommodate the organization of microtubule (MT) networks to control nuclear positioning and dynein motor-based retrograde endosomal trafficking (PubMed:32066907). Within the ncMTOCs, Msp300 and shot anchors the ncMTOC at the nuclear surface and recruits the MT minus-end regulators Patronin and Nin for assembly, anchoring and/or stabilization of circumferential and radial MTs at the ncMTOC (PubMed:32066907). This protein may also function with Patronin to recruit msps to the ncMTOC for the gamma-tubulin-independent elongation of radial MTs (PubMed:32066907). In embryonic myotubes and larval myofibers, functions with ens to regulate myonuclear positioning and, as a consequence, is involved in muscle development (PubMed:30626718). Likely functions by positively regulating ens (PubMed:30626718). Essential for embryogenesis, likely by contributing to accurate chromosome segregation during early embryonic nuclear divisions (PubMed:27422905). However, other reports found that it is not essential for embryogenesis or embryonic cellular divisions (PubMed:27053665, PubMed:30626718)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C9QPC2;Q8IPK7;Q9VMS6", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0000242 pericentriolar material", "go_biological_process": "GO:0034994 microtubule organizing center attachment site organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P11929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24322-1", "uniprot_id": "SEM1A_DROME", "mass": 101057.0, "length": 899, "protein_name": "Semaphorin-1A", "gene_name": "Sema1a", "organism": "Fruit fly", "refseq_name": "semaphorin 1a, isoform A", "refseq_ac": "NP_723407", "gene_names_uniprotkb": "Sema1a; BcDNA:RE36155; CG18405; CT26404; D-Sema 1a; D-Sema I; D-Sema-I; D-SemaI; D-semaI; Dmel\\CG18405; Dmel_CG18405; Dsema 1a; Dsema-I; Fas-IV; FasIV; SEMA-1A; Sema 1a; Sema-1a; Sema-I; Sema1A; SemaI; d-sema I; d-semaI; l(2)k13702; sema 1a; sema-1a; sema-I; sema1a; sema", "gene_names_refseq": "BcDNA:RE36155; CG18405; CT26404; D-Sema 1a; D-Sema I; D-Sema-I; D-SemaI; D-semaI; Dmel\\CG18405; Dsema 1a; Dsema-I; Fas-IV; FasIV; SEMA-1A; Sema 1a; Sema-1a; Sema-I; Sema1A; Sema1a; SemaI; d-sema I; d-semaI; l(2)k13702; sema 1a; sema-1a; sema-I; sema1a; sema", "protein_names_uniprotkb": "Semaphorin-1A; Sema I; Semaphorin-I", "protein_names_refseq": "CG18405-PA; Fasciclin-IV; Sema-1a; Sema1a-PA; Semaphorin-1A; semaphorin 1a, isoform A; semaphorin 1; semaphorin I; semaphorin1a; semiphorin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18405); (R-DME-416572); (R-DME-416700)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15282266;16110336;17569856;17569867;25589440;26109356;26109357;37041188;8269517", "class_list": "", "function": "Involved in growth cone guidance through its role in axonal repulsion (PubMed:15282266, PubMed:8269517). Function in neurons is essential for adult survival, motor neuron survival, and is important for climbing behavior and activity (PubMed:37041188)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8MYZ9", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0016199 axon midline choice point recognition;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q24322-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22978-1", "uniprot_id": "CG445_DROME", "mass": 12614.0, "length": 111, "protein_name": "Rhodanese domain-containing protein CG4456", "gene_name": "small hsp locus 67B", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001027116", "gene_names_uniprotkb": "small hsp locus 67B; CG32041; CG4456; Dmel\\CG4456; Dmel_CG4456; EP(3)3247; Hsp-G2; Hsp67Bb; Hspg2; anon-WO0118547.50; anon-WO0140519.138; gene 2; gene-2; gene2; gene4; hsp67Bb; hsp67B", "gene_names_refseq": "CG32041; CG4456; Dmel\\CG4456; EP(3)3247; Hsp-G2; Hsp67Bb; Hspg2; anon-WO0118547.50; anon-WO0140519.138; gene 2; gene-2; gene2; gene4; hsp67Bb; hsp67B; small hsp locus 67B", "protein_names_uniprotkb": "Rhodanese domain-containing protein CG4456; Heat shock protein 67B2", "protein_names_refseq": "CG4456-PB; gene 2; heat shock gene 2; heat shock gene 67Bb; heatshock protein 67Bb; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4456)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2454316;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F0J880;Q0E8G7;Q9VSX0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P22978-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SX83-1", "uniprot_id": "SPEN_DROME", "mass": 600000.0, "length": 5560, "protein_name": "Protein split ends", "gene_name": "spen", "organism": "Fruit fly", "refseq_name": "split ends, isoform B", "refseq_ac": "NP_524718", "gene_names_uniprotkb": "spen; 24; BcDNA:GM01870; CG18497; Dmel\\CG18497; Dmel_CG18497; E(E2F)2A; E(Raf)2A; E(Sev-CycE)2A; EK2-9; EY2-7; En(yan[ACT])2-7; SPEN; Spen; Splitends; l(2)03350; l(2)k06805; l(2)k07612; l(2)k08102; poc; rno; spe; yip1", "gene_names_refseq": "136/24; BcDNA:GM01870; CG18497; Dmel\\CG18497; E(E2F)2A; E(Raf)2A; E(Sev-CycE)2A; EK2-9; EY2-7; En(yan[ACT])2-7; SPEN; Spen; Splitends; l(2)03350; l(2)k06805; l(2)k07612; l(2)k08102; poc; rno; spen; spe; yip1", "protein_names_uniprotkb": "Protein split ends", "protein_names_refseq": "CG18497-PB; polycephalon; rhinoceros; spen-PB; split ends, isoform B; split ends; split-ends; splitends; yippee interacting protein 1", "tax_id": 7227, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dme:Dmel_CG18497); (R-DME-9013422)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10556062;10655223;10704397;10731132;10790398;10959845;12537568;12537569;12537572;12537573;12537574;12783785;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Probable corepressor protein, which regulates different key pathways such as the EGF receptor and Wg pathways. Involved in neuronal cell fate, survival and axon guidance, cell cycle regulation and repression of head identity in the embryonic trunk. May act with the Hox gene Deformed and the EGF receptor signaling pathway. Positive regulator of the Wg pathway in larval tissues but not in embryonic tissues. May act as a transcriptional corepressor protein, which repress transcription via the recruitment of large complexes containing histone deacetylase proteins., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 0, "predicted_o_glycosites": 12, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q9NHN1;Q9NJ17;Q9U6C3;Q9VPL1;Q9VPL2", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048749 compound eye development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007422 peripheral nervous system development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8SX83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43248-1", "uniprot_id": "MSH2_DROME", "mass": 103313.0, "length": 917, "protein_name": "DNA mismatch repair protein spellchecker 1", "gene_name": "spel1", "organism": "Fruit fly", "refseq_name": "spellchecker1, isoform E", "refseq_ac": "NP_001014482", "gene_names_uniprotkb": "spel1; BG:DS01068.9; CG4215; Dmel\\CG4215; Dmel_CG4215; Msh2; SPEL1; spel-1; spel", "gene_names_refseq": "BG:DS01068.9; CG4215; Dmel\\CG4215; Msh2; SPEL1; spel-1; spel1; spel", "protein_names_uniprotkb": "DNA mismatch repair protein spellchecker 1", "protein_names_refseq": "CG4215-PE; spel1-PE; spellchecker 1; spellchecker1, isoform E; spellchecker", "tax_id": 7227, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); colitis (Disease Ontology:DOID:0060180); hereditary nonpolyposis colorectal cancer type 8 (Disease Ontology:DOID:0070270); Lynch syndrome 1 (Disease Ontology:DOID:0070271); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); primary ovarian insufficiency (Disease Ontology:DOID:5426); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG4215); (R-DME-5358565)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10077620;10471707;10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR)., [UniProtKB, UniProtKB]; Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86BK6;Q9NKC4;Q9VJT0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0032301 MutSalpha complex;GO:0005634 nucleus", "go_biological_process": "GO:0006312 mitotic recombination;GO:0006298 mismatch repair;GO:0036297 interstrand cross-link repair;GO:0043570 maintenance of DNA repeat elements;GO:0006301 DNA damage tolerance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P43248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6J5K9-1", "uniprot_id": "ARMI_DROME", "mass": 135658.0, "length": 1188, "protein_name": "5'-3' RNA helicase armi", "gene_name": "armi", "organism": "Fruit fly", "refseq_name": "armitage, isoform B", "refseq_ac": "NP_001014556", "gene_names_uniprotkb": "armi; APC16; ARMI; Armi; CG11513; Dmel\\CG11513; Dmel_CG11513", "gene_names_refseq": "APC16; ARMI; Armi; CG11513; Dmel\\CG11513; armi", "protein_names_uniprotkb": "5'-3' RNA helicase armi; 5.6.2.5; Protein armitage", "protein_names_refseq": "CG11513-PB; armi-PB; armitage, isoform B; armitage", "tax_id": 7227, "disease": "spermatogenic failure 73 (Disease Ontology:DOID:0070572); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dme:Dmel_CG11513); (R-DME-400206); (R-DME-9707564)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15035984;15035985;16110336;17428915;17569856;17569867;20966047;25589440;26109356;26109357;28827804", "class_list": "", "function": "RNA helicase required for axial polarization of the oocyte during early and mid oogenesis (PubMed:15035984). Has ATP-dependent 5'-3' RNA helicase activity (PubMed:28827804). Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression (PubMed:15035984). Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression (PubMed:15035985). May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key step in RISC formation (PubMed:15035985). Required both for the translational control of oskar (osk) mRNA and cytoskeletal polarization in the oocyte (PubMed:15035984). Required for somatic primary piRNA biogenesis (PubMed:20966047, PubMed:28827804). Involved in repression of long interspersed nuclear elements (LINEs) including HeT-A, I-element and TART LINEs (PubMed:17428915)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q59E56;Q9VZP4", "ec_number_list": "3.6.4.13;7.2.2.-;2.3.1.48;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;3.5.1.98;5.6.2.3;3.1.-.-;3.6.1.15;2.1.1.319;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0034584 piRNA binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0031315 extrinsic component of mitochondrial outer membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0070922 RISC complex assembly;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0007616 long-term memory;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6J5K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50445-1", "uniprot_id": "RUX_DROME", "mass": 37898.0, "length": 335, "protein_name": "Cell cycle negative regulator roughex", "gene_name": "rux", "organism": "Fruit fly", "refseq_name": "roughex, isoform B", "refseq_ac": "NP_001245540", "gene_names_uniprotkb": "rux; CG4336; Dmel\\CG4336; Dmel_CG4336; Rux", "gene_names_refseq": "CG4336; Dmel\\CG4336; Rux; rux", "protein_names_uniprotkb": "Cell cycle negative regulator roughex", "protein_names_refseq": "CG4336-PB; Rough-ex; roughex, isoform B; roughex; rux-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4336)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8020091", "class_list": "", "function": "Negative regulator of both mitosis and meiosis. Required for the establishment of the G1 phase in the developing eye., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540W5;Q9W446", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007096 regulation of exit from mitosis;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P50445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16568-1", "uniprot_id": "BICD_DROME", "mass": 88954.0, "length": 782, "protein_name": "Protein bicaudal D", "gene_name": "BicD", "organism": "Fruit fly", "refseq_name": "bicaudal D, isoform C", "refseq_ac": "NP_001260530", "gene_names_uniprotkb": "BicD; BIC-D; BICD; Bic-D; Bic[D]; CG6605; Dmel\\CG6605; Dmel_CG6605; anon-EST:fe2A11; bicD", "gene_names_refseq": "BIC-D; BICD; Bic-D; BicD; Bic[D]; CG6605; Dmel\\CG6605; anon-EST:fe2A11; bicD", "protein_names_uniprotkb": "Protein bicaudal D", "protein_names_refseq": "BicD-PC; Bicaudal-D; BicaudalD; Bicuadal-D; CG6605-PC; almond; anon-fast-evolving-2A11; bicaudal D, isoform C; bicaudal D", "tax_id": 7227, "disease": "spinal muscular atrophy with lower extremity predominant 2A (Disease Ontology:DOID:0070349); spinal muscular atrophy with lower extremity predominant 2B (Disease Ontology:DOID:0070350)", "pathway": " (dme:Dmel_CG6605); (R-DME-6811436)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10731132;11546740;12537568;12537569;12537572;12537573;12537574;16110336;17329360;17372656;17569856;17569867;17827179;18327897;19234596;25589440;2576013;2590944;26109356;26109357;31626769;38264934", "class_list": "", "function": "This protein is essential for differentiation. It may play a role in localizing of Nanos (a maternal determinant) activity in oocytes. Functions redundantly with BicDR (PubMed:38264934). During oogenesis, plays a specific role, together with Rab6 but independently of Sec5, in the polarization of the oocyte microtubule cytoskeleton, in oskar mRNA localization and in the anterodorsal secretion of grk. Plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769). During macrochaetae development, together with BicDR, involved in Rab 6 and Spn-F stability and distribution and actin cytoskeleton organization (PubMed:38264934)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VJD5", "ec_number_list": "", "go_molecular_function": "GO:0008093 cytoskeletal anchor activity;GO:0031267 small GTPase binding;GO:0070840 dynein complex binding;GO:0034452 dynactin binding;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0098793 presynapse", "go_biological_process": "GO:0098840 protein transport along microtubule;GO:2000302 positive regulation of synaptic vesicle exocytosis;GO:0030100 regulation of endocytosis;GO:0048477 oogenesis;GO:0050658 RNA transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P16568-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24562-1", "uniprot_id": "U2AF2_DROME", "mass": 46655.0, "length": 416, "protein_name": "Splicing factor U2AF 50 kDa subunit", "gene_name": "U2af50", "organism": "Fruit fly", "refseq_name": "U2 small nuclear riboprotein auxiliary factor 50, isoform D", "refseq_ac": "NP_001245710", "gene_names_uniprotkb": "U2af50; 9-21; CG9998; DU2AF50; DmU2AF[50]; Dmel\\CG9998; Dmel_CG9998; U2AF 50; U2AF-50; U2AF50; U2AF; U2af; dU2AF50; dU2AF[50]; dUTAf[50]; l(1)14Ca; l(1)14Cc; l(1)9-21", "gene_names_refseq": "9-21; CG9998; DU2AF50; DmU2AF[50]; Dmel\\CG9998; U2AF 50; U2AF-50; U2AF50; U2AF; U2af50; U2af; dU2AF50; dU2AF[50]; dUTAf[50]; l(1)14Ca; l(1)14Cc; l(1)9-21", "protein_names_uniprotkb": "Splicing factor U2AF 50 kDa subunit; U2 auxiliary factor 50 kDa subunit; U2 snRNP auxiliary factor large subunit", "protein_names_refseq": "CG9998-PD; U2 small nuclear riboprotein auxiliary factor 50, isoform D; U2af50-PD", "tax_id": 7227, "disease": "developmental delay, dysmorphic facies, and brain anomalies (Disease Ontology:DOID:0060933)", "pathway": " (dme:Dmel_CG9998); (R-DME-159236); (R-DME-9629569); (R-DME-9770562)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7692602", "class_list": "", "function": "Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXH2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0008187 poly-pyrimidine tract binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0008380 RNA splicing;GO:0051168 nuclear export;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q24562-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02516-1", "uniprot_id": "HSP23_DROME", "mass": 20629.0, "length": 186, "protein_name": "Heat shock protein 23", "gene_name": "Hsp23", "organism": "Fruit fly", "refseq_name": "heat shock protein 23, isoform B", "refseq_ac": "NP_001246694", "gene_names_uniprotkb": "Hsp23; 22; 23; CG4463; DmHSP23; DmHsp23; Dmel20.6; Dmel\\CG4463; Dmel_CG4463; HSP23; Hsp-23; IAP; hsp 22K; hsp 23K; hsp 23; hsp-23; hsp23; small hsp locus 67B", "gene_names_refseq": "23; CG4463; DmHSP23; DmHsp23; Dmel20.6; Dmel\\CG4463; HSP23/IAP; HSP23; Hsp-23; Hsp23; hsp 22K; hsp 23K; hsp 23; hsp-23; hsp23/22; hsp23; small hsp locus 67B", "protein_names_uniprotkb": "Heat shock protein 23", "protein_names_refseq": "CG4463-PB; Hsp 23; Hsp23-PB; heat shock protein 23, isoform B; heat-shock protein 23; protein 23", "tax_id": 7227, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); infantile-onset myofibrillar myopathy-2B (Disease Ontology:DOID:0080309); cataract 16 multiple types (Disease Ontology:DOID:0110250); cataract 9 multiple types (Disease Ontology:DOID:0110266); dilated cardiomyopathy 1II (Disease Ontology:DOID:0110450); neurodegenerative disease (Disease Ontology:DOID:1289); macular degeneration (Disease Ontology:DOID:4448); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (dme:Dmel_CG4463); (R-DME-3371571)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;6285380;6302284", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VSX5", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001666 response to hypoxia;GO:0006457 protein folding;GO:0009631 cold acclimation;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P02516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24432-1", "uniprot_id": "OMB_DROME", "mass": 102565.0, "length": 972, "protein_name": "Optomotor-blind protein", "gene_name": "bi", "organism": "Fruit fly", "refseq_name": "bifid, isoform B", "refseq_ac": "NP_001162662", "gene_names_uniprotkb": "bi; BI; CG3578; Dm-OMB; Dm-omb; Dmel\\CG3578; Dmel_CG3578; OMB; Omb; Qd; T3; TBX2; dm-omb; l(1)bi; l(1)omb; omb", "gene_names_refseq": "BI; CG3578; Dm-OMB; Dm-omb; Dmel\\CG3578; OMB; Omb; Qd; T3; TBX2; bi; dm-omb; l(1)bi; l(1)omb; omb", "protein_names_uniprotkb": "Optomotor-blind protein; L(1)omb; Lethal(1)optomotor-blind; Protein bifid", "protein_names_refseq": "CG3578-PB; Optimotor-blind; bi-PB; bifid, isoform B; lethal(l)optomotor-blind; opomoter-blind; optimotor blind; optomer-blind; optomoter blind; optomoter-blind; optomotor blind; optomotor-blind gene; optomotor-blind; optomotorblind; quadroon", "tax_id": 7227, "disease": "ulnar-mammary syndrome (Disease Ontology:DOID:0060614); vertebral anomalies and variable endocrine and T-cell dysfunction (Disease Ontology:DOID:0070345); stomach cancer (Disease Ontology:DOID:10534); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162); heart septal defect (Disease Ontology:DOID:1681); atrial heart septal defect (Disease Ontology:DOID:1882); ovarian cancer (Disease Ontology:DOID:2394); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG3578); (R-DME-9856649)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;1741374;17569856;17569867;18327897;25589440;26109356;26109357;8492800", "class_list": "", "function": "Essential protein that may function as a transcription regulator. Vital for pupal development. Required for proper development of the optic lobes and wings, and abdominal pigmentation., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E1JJD8;Q27917;Q9W4K5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15372-1", "uniprot_id": "ARRA_DROME", "mass": 40771.0, "length": 364, "protein_name": "Phosrestin-2", "gene_name": "Arr1", "organism": "Fruit fly", "refseq_name": "arrestin 1, isoform B", "refseq_ac": "NP_001246073", "gene_names_uniprotkb": "Arr1; 3H10; ARR1; ArrA; Arr; CG5711; DAI; DA; DS-Ag; DmArr1; DmArrestin-1; Dmarrestin; Dmel\\CG5711; Dmel_CG5711; Dro.-Arr.I; PRII; arr1", "gene_names_refseq": "3H10; ARR1; Arr1; ArrA; Arr; CG5711; DAI; DA; DS-Ag; DmArr1; DmArrestin-1; Dmarrestin; Dmel\\CG5711; Dro.-Arr.I; PRII; arr1", "protein_names_uniprotkb": "Phosrestin-2; Arrestin-1; Arrestin-A; Phosrestin II", "protein_names_refseq": "Arr1-PB; Arrestin1; CG5711-PB; Phosrestin-II; arrestin 1, isoform B; arrestin 1; arrestin A; drosophila arrestin", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); major depressive disorder (Disease Ontology:DOID:1470); drug psychosis (Disease Ontology:DOID:1742); brain infarction (Disease Ontology:DOID:3454); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG5711); (R-DME-418555); (R-DME-432720); (R-DME-432722); (R-DME-5674135); (R-DME-5689880); (R-DME-8856825); (R-DME-8856828); (R-DME-9839389)", "pathway_count": 9, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;1689056;17569856;17569867;1905538;2105491;25589440;26109356;26109357;36994075;8316831", "class_list": "", "function": "Regulates photoreceptor cell deactivation (PubMed:8316831). Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction cascade (PubMed:8316831). Involved in regulating normal cycles of per nuclear accumulation in brain circadian neurons and thus is important for normal circadian behavior (PubMed:36994075). In the dark, functions with Arr2 to promote the formation of cytosolic Bdbt foci, which are required for dco localization to photoreceptor nuclei where it phosphorylates and activates degradation of per (PubMed:36994075)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VJA8", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0002046 opsin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016028 rhabdomere", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007600 sensory perception;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P15372-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20241-1", "uniprot_id": "NRG_DROME", "mass": 143618.0, "length": 1302, "protein_name": "Neuroglian", "gene_name": "Nrg", "organism": "Fruit fly", "refseq_name": "neuroglian, isoform D", "refseq_ac": "NP_001162704", "gene_names_uniprotkb": "Nrg; CG1634; CT4318; Dmel\\CG1634; Dmel_CG1634; NFASC; NRG; Ngl; Nrg167; Nrg180; RA35; ceb; fs(1)M72; ibx; l(1)7Fa; l(1)G0099; l(1)G0413; l(1)G0488; nrg", "gene_names_refseq": "CG1634; CT4318; Dmel\\CG1634; NFASC; NRG; Ngl; Nrg167; Nrg180; Nrg; RA35; ceb; fs(1)M72; ibx; l(1)7Fa; l(1)G0099; l(1)G0413; l(1)G0488; nrg", "protein_names_uniprotkb": "Neuroglian", "protein_names_refseq": "CG1634-PD; Nrg-PD; central brain deranged; female sterile(1)M72; icebox; lethal (1) G0488; neuroglian, isoform D; neuroglian", "tax_id": 7227, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); autism spectrum disorder (Disease Ontology:DOID:0060041); MASA syndrome (Disease Ontology:DOID:0060246); Alzheimer's disease (Disease Ontology:DOID:10652); hydrocephalus (Disease Ontology:DOID:10908); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); glioblastoma (Disease Ontology:DOID:3068); bipolar disorder (Disease Ontology:DOID:3312); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); uterine cancer (Disease Ontology:DOID:363); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG1634); (R-DME-1474228); (R-DME-1971475); (R-DME-2022928); (R-DME-2024096); (R-DME-216083); (R-DME-3000171); (R-DME-3000178); (R-DME-375165); (R-DME-419037); (R-DME-445144); (R-DME-5673001); (R-DME-9769739); (R-DME-9913351)", "pathway_count": 14, "publication_count": 21, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15459097;16110336;1693086;17569856;17569867;17893096;19349973;20935638;25589440;26109356;26109357;2805067;28977027;7512815;9666073", "class_list": "", "function": "Essential for septate junctions. Septate junctions, which are the equivalent of vertebrate tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for formation of the hemolymph-brain barrier (the insect blood-brain barrier). Vital for embryonic development. Involved in the targeting for degradation or recycling of certain septate junction components, including kune and bou/boudin, by regulating their endocytosis (PubMed:28977027)., [UniProtKB, PubMed, PubMed]; May be a more general cell adhesion molecule involved in non-neuronal tissues and imaginal disk morphogenesis., [UniProtKB, PubMed]; May play a role in neural and glial cell adhesion in the developing embryo., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A4V452;E1JJF8;E1JJF9;O61541;O61542;Q1WWD5;Q24414;Q24415;Q95U64;Q9V3X0", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007409 axonogenesis;GO:0050808 synapse organization;GO:0098609 cell-cell adhesion;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P20241-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83094-1", "uniprot_id": "STIM_DROME", "mass": 64797.0, "length": 570, "protein_name": "Stromal interaction molecule homolog", "gene_name": "Stim", "organism": "Fruit fly", "refseq_name": "stromal interaction molecule, isoform A", "refseq_ac": "NP_523357", "gene_names_uniprotkb": "Stim; C-Stim; CG9126; D-STIM; D-Stim; Dmel\\CG9126; Dmel_CG9126; STIM1; STIM; dSTIM; dStim; dstim; stim1; stim", "gene_names_refseq": "C-Stim; CG9126; D-STIM; D-Stim; Dmel\\CG9126; STIM1; STIM; Stim; dSTIM; dStim; dstim; stim1; stim", "protein_names_uniprotkb": "Stromal interaction molecule homolog", "protein_names_refseq": "CG9126-PA; Stim-PA; drosophila stromal interaction molecule; stromal interaction molecule 1; stromal interaction molecule, isoform A; stromal interaction molecule", "tax_id": 7227, "disease": "Stormorken syndrome (Disease Ontology:DOID:0060354); tubular aggregate myopathy 1 (Disease Ontology:DOID:0080089); immunodeficiency 10 (Disease Ontology:DOID:0111970); stomach cancer (Disease Ontology:DOID:10534); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG9126); (R-DME-5578775); (R-DME-983695)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10731132;11463338;12537568;12537569;12537572;12537573;12537574;15866891;16110336;16208375;17569856;17569867;18327897;25589440;26109356;26109357;33925313", "class_list": "", "function": "Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXL6", "ec_number_list": "", "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding;GO:0048763 calcium-induced calcium release activity;GO:0015279 store-operated calcium channel activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0051924 regulation of calcium ion transport;GO:0005513 detection of calcium ion;GO:0002115 store-operated calcium entry;GO:0007476 imaginal disc-derived wing morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P83094-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33085-1", "uniprot_id": "SHAKB_DROME", "mass": 44355.0, "length": 372, "protein_name": "Innexin shaking-B", "gene_name": "shakB", "organism": "Fruit fly", "refseq_name": "shaking B, isoform E", "refseq_ac": "NP_001097038", "gene_names_uniprotkb": "shakB; 2; 3; 6; CG12678; CG1321; CG15451; CG32508; CG34358; Dmel\\CG34358; Dmel_CG34358; E81; FBpp0111481; Inx8; Pas; R-9-29; R9-29; SHAK-B; Shak B; Shak-B; ShakB; W3; inx8; inx; l(1)19Eb; l(1)LB21; l(1)R-10-14; l(1)R-10-3; l(1)R-10-7; l(1)R-9-29; l(1)TH73; l(1)W3b; l(1)W3; lincRNA.1031; nj-156; nj156; pass; pas; shB; shak-B; shkB", "gene_names_refseq": "2; 3; 6; CG12678; CG1321; CG15451; CG32508; CG34358; Dmel\\CG34358; E81; FBpp0111481; Inx8; Pas; R-9-29; R9-29; SHAK-B; Shak B; Shak-B; ShakB; W3; inx8; l(1)19Eb; l(1)LB21; l(1)R-10-14; l(1)R-10-3; l(1)R-10-7; l(1)R-9-29; l(1)TH73; l(1)W3b; l(1)W3; lincRNA.1031; nj-156; nj156; pass; pas; shB; shak-B; shakB; shkB", "protein_names_uniprotkb": "Innexin shaking-B; Protein passover", "protein_names_refseq": "CG34358-PE; Shaking-B; non-jumper-156; passover-vital protein; section 2; section 3; section 6; shakB-PE; shaking B, isoform E; shaking B; shakingB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34358)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10440730;10731132;12537568;12537572;12537573;12537574;1487155;16110336;17569856;17569867;25589440;26109356;26109357;7601305;7892218;8500183;9428764;9552170", "class_list": "", "function": "Structural component of the gap junctions at electrical synapses in distal and mid-depth levels in the lamina. Isoform Lethal forms voltage sensitive intercellular channels through homotypic interactions., [UniProtKB, PubMed, PubMed]; Structural component of the gap junctions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JUT3;B7Z104;Q1RKZ8;Q24011;Q24520;Q26432;Q9VRB9;Q9VRC0;Q9VRC2", "ec_number_list": "", "go_molecular_function": "GO:0009881 photoreceptor activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005921 gap junction", "go_biological_process": "GO:0055085 transmembrane transport;GO:0034220 monoatomic ion transmembrane transport;GO:0009416 response to light stimulus;GO:0007602 phototransduction;GO:0003254 regulation of membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P33085-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23645-1", "uniprot_id": "BIB_DROME", "mass": 76509.0, "length": 696, "protein_name": "Neurogenic protein big brain", "gene_name": "bib", "organism": "Fruit fly", "refseq_name": "big brain, isoform A", "refseq_ac": "NP_476837", "gene_names_uniprotkb": "bib; BIB_DROME; BIB; Bib; CG4722; DmBIB; Dmel\\CG4722; Dmel_CG4722; EP(2)2278; l(2)neo66; l(2)neo91; m-bib", "gene_names_refseq": "BIB_DROME; BIB; Bib; CG4722; DmBIB; Dmel\\CG4722; EP(2)2278; bib; l(2)neo66; l(2)neo91; m-bib", "protein_names_uniprotkb": "Neurogenic protein big brain", "protein_names_refseq": "Big brain; CG4722-PA; bib-PA; big brain, isoform A", "tax_id": 7227, "disease": "Alpers-Huttenlocher syndrome (Disease Ontology:DOID:0080122); megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); transverse myelitis (Disease Ontology:DOID:0080743); Bothnian type palmoplantar keratoderma (Disease Ontology:DOID:0111707); Alzheimer's disease (Disease Ontology:DOID:10652); optic neuritis (Disease Ontology:DOID:1210); blindness (Disease Ontology:DOID:1432); thymoma (Disease Ontology:DOID:3275); temporal lobe epilepsy (Disease Ontology:DOID:3328); brain edema (Disease Ontology:DOID:4724); central pontine myelinolysis (Disease Ontology:DOID:636); neuromyelitis optica (Disease Ontology:DOID:8869); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); intracranial hypertension (Disease Ontology:DOID:9428); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (dme:Dmel_CG4722)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10731132;11923418;12537568;12537569;12537572;12537573;12537574;1483394;14990474;16110336;1692392;17569856;17569867;18327897;25589440;26109356;26109357;9367444", "class_list": "", "function": "Essential for proper differentiation of ectoderm. Acts synergistically with neurogenic locus proteins Notch and Delta during the separation of neural and epidermal cell lineages in response to the lateral inhibition signal. Voltage-insensitive monovalent cation channel. Ion transport is blocked by the presence of divalent cations., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VL53", "ec_number_list": "", "go_molecular_function": "GO:0015267 channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0055085 transmembrane transport;GO:0098609 cell-cell adhesion;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P23645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24174-1", "uniprot_id": "ABRU_DROME", "mass": 95093.0, "length": 904, "protein_name": "Protein abrupt", "gene_name": "ab", "organism": "Fruit fly", "refseq_name": "abrupt, isoform B", "refseq_ac": "NP_001162952", "gene_names_uniprotkb": "ab; Ab; B2149; CG32830; CG43860; CG4807; Dmel\\CG43860; Dmel_CG43860; clu; l(2)k02807; ptd", "gene_names_refseq": "Ab; B2149; CG32830; CG43860; CG4807; Dmel\\CG43860; ab; clu; l(2)k02807; ptd", "protein_names_uniprotkb": "Protein abrupt; Protein clueless", "protein_names_refseq": "CG43860-PB; ab-PB; abrupt, isoform B; abrupt; clueless; parted", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43860)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15363392;16110336;17569856;17569867;18327897;25589440;26109356;26109357;7498790", "class_list": "", "function": "Expression is vital for development; may be involved in transcriptional regulation. In embryos, muscle specific expression is required for segmental nerve b (SNb) motoneuron target recognition within ventral longitudinal muscles. Has a role in establishing and maintaining embryonic muscle attachments, adult sensory cell formation (macrochaetae) and morphogenesis of adult appendages (legs, antenna aristae and male external genitalia). Has a role in the morphogenesis of the class I dendritic neurons: selective expression of ab in class I da neurons plays a pivotal role in forming dendritic arbors, which are characteristic of the class I cells. The development of more complex arbors of class II-IV neurons depends on the absence of ab., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JHF4;Q86NP4;Q9VKI1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016198 axon choice point recognition;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q24174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8I7Z8-1", "uniprot_id": "HAM_DROME", "mass": 109228.0, "length": 990, "protein_name": "Transcription factor hamlet", "gene_name": "ham", "organism": "Fruit fly", "refseq_name": "hamlet, isoform B", "refseq_ac": "NP_001246081", "gene_names_uniprotkb": "ham; CG10568; CG15906; CG15907; CG31753; Dmel\\CG31753; Dmel_CG31753; HAM_DROME; Ham", "gene_names_refseq": "CG10568; CG15906; CG15907; CG31753; Dmel\\CG31753; HAM_DROME; Ham; ham", "protein_names_uniprotkb": "Transcription factor hamlet", "protein_names_refseq": "CG31753-PB; ham-PB; hamlet, isoform B; hamlet", "tax_id": 7227, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); myeloid neoplasm (Disease Ontology:DOID:0070004); dilated cardiomyopathy 1LL (Disease Ontology:DOID:0081157); otitis media (Disease Ontology:DOID:10754)", "pathway": " (dme:Dmel_CG31753); (R-DME-8943724)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12193790;12537568;12537572;12537573;12537574;15075290;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Transcription factor that plays a crucial role in external sensory organ (ESO) that elaborates from a single precursor cell (ESOP cell). Mediates the differentiation of lineage branch that generates the internal 'ES' and 'th' cells (external sensory neuron and thecogen cells, respectively) from the IIIB cell. Its absence leads to re-specification of IIIB daughter cells into external tormagen cells (tr cells), or internal multidendritic neurons (MD cells). One of its role in the development of the ESO lineage is to modulate the activity of Notch and PAX2 signals., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9VJ50;Q9VJ52", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0046974 histone H3K9 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8I7Z8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q94535-1", "uniprot_id": "U2AF1_DROME", "mass": 29877.0, "length": 264, "protein_name": "Splicing factor U2af 38 kDa subunit", "gene_name": "U2af38", "organism": "Fruit fly", "refseq_name": "U2 small nuclear riboprotein auxiliary factor 38, isoform B", "refseq_ac": "NP_001259814", "gene_names_uniprotkb": "U2af38; CG3582; DU2AF38; Dmel\\CG3582; Dmel_CG3582; U2AF 38; U2AF38; U2AF; Utaf38; dU2AF38; dU2AF[38]; l(2)06751; u2af38", "gene_names_refseq": "CG3582; DU2AF38; Dmel\\CG3582; U2AF 38; U2AF38; U2AF; U2af38; Utaf38; dU2AF38; dU2AF[38]; l(2)06751; u2af38", "protein_names_uniprotkb": "Splicing factor U2af 38 kDa subunit; U2 auxiliary factor 38 kDa subunit; U2 snRNP auxiliary factor small subunit", "protein_names_refseq": "CG3582-PB; U2 small nuclear riboprotein auxiliary factor 38, isoform B; U2af38-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3582); (R-DME-159236); (R-DME-9770562)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8816800", "class_list": "", "function": "Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VPN4", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0008187 poly-pyrimidine tract binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0089701 U2AF complex", "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q94535-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q59E55-1", "uniprot_id": "NAB_DROME", "mass": 66488.0, "length": 625, "protein_name": "NGFI-A-binding protein homolog", "gene_name": "nab", "organism": "Fruit fly", "refseq_name": "nab, isoform C", "refseq_ac": "NP_001014557", "gene_names_uniprotkb": "nab; CG15000; CG15001; CG33545; Dmel\\CG33545; Dmel_CG33545; NAB; Nab; dNAB; dnab; l(2)SH3 143; l(3)64Aj; l(3)SH143; l(3)SH21", "gene_names_refseq": "CG15000; CG15001; CG33545; Dmel\\CG33545; NAB; Nab; dNAB; dnab; l(2)SH3 143; l(3)64Aj; l(3)SH143; l(3)SH21; nab", "protein_names_uniprotkb": "NGFI-A-binding protein homolog; dNAB", "protein_names_refseq": "CG33545-PC; lethal (3) SH143; nab, isoform C; nab-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33545); (R-DME-9031628)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12508226;12537568;12537572;12537573;12537574;16110336;17428824;17569856;17569867;18571155;25589440;26109356;26109357", "class_list": "", "function": "Transcriptional regulator that can both act as a coactivator or a corepressor depending on the context. Lacks DNA-binding domains and acts by associating with other transcription factors such as rotund (rn) and squeeze (sqz). Acts as a coactivator of sqz and is required to limit the number of neurons that express the LIM-homeodomain gene apterous and to specify Tv neuronal fate. Acts as a corepressor of rn in wing development and is required to limit the expression of wingless (wg) in the wing hinge, where wg plays a mitogenic role., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B5X541;E1JIC7", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007626 locomotory behavior;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q59E55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48598-1", "uniprot_id": "IF4E_DROME", "mass": 29224.0, "length": 259, "protein_name": "Eukaryotic translation initiation factor 4E1", "gene_name": "eIF4E1", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 4E1, isoform H", "refseq_ac": "NP_001261626", "gene_names_uniprotkb": "eIF4E1; 09; 11; 12; 13; 2; 7238; CBP; CG4035; CT13384; CT39424; CT39426; D-eIF4E; Dmel\\CG4035; Dmel_CG4035; EIF4E; Eif4E; Eif4e; IF4E; dEif-4e; dEif4e; deIF-4E; deIF4E; eIF 4E; eIF-4E1; eIF-4E2; eIF-4EII; eIF-4E; eIF-4e; eIF4E-1; eIF4E-2; eIF4EI; eIF4E; eIF4F; eIF4e; eiF4E; eif-4E; eif-4e; eif4e; elF4E; l(3)07238; l(3)67Af; l(3)S025007; l(3)S026009; l(3)S058711; l(3)S091912", "gene_names_refseq": "0260/09; 0587/11; 0589/11; 0919/12; 1004/13; 2; 7238; CBP; CG4035; CT13384; CT39424; CT39426; D-eIF4E; Dmel\\CG4035; EIF4E; Eif4E; Eif4e; IF4E; dEif-4e; dEif4e; deIF-4E; deIF4E; eIF 4E; eIF-4E1; eIF-4E2; eIF-4EII; eIF-4E; eIF-4e; eIF4E-1/2; eIF4E-1; eIF4E-2; eIF4E1; eIF4EI; eIF4E; eIF4F; eIF4e; eiF4E; eif-4E; eif-4e; eif4e; elF4E; l(3)07238; l(3)67Af; l(3)S025007; l(3)S026009; l(3)S058711; l(3)S091912", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E1; eIF-4F 25 kDa subunit; mRNA cap-binding protein", "protein_names_refseq": "CG4035-PH; cap binding protein; eIF4E1-PH; eukaryotic initiation factor 4E; eukaryotic translation initiation factor 4E1, isoform H; eukaryotic translation initiation factor 4E; lethal(3)67Af", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (dme:Dmel_CG4035); (R-DME-110523); (R-DME-156827); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-166208); (R-DME-429947); (R-DME-72649); (R-DME-72662); (R-DME-72702)", "pathway_count": 11, "publication_count": 33, "publication_id_list": "10731132;11389445;11500381;11752451;12172554;12537568;12537569;12537572;12537573;12537574;12771962;14645523;14685270;14691132;14723848;16110336;17178403;17569856;17569867;20869429;22745595;22832024;23716590;25589440;25702871;26109356;26109357;26294658;28875934;40245499;7742371;8663200;9065696", "class_list": "", "function": "Recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:8663200). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4V1Q6;Q95SV3;Q9VSX8;Q9VSX9", "ec_number_list": "", "go_molecular_function": "GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity;GO:0000339 RNA cap binding;GO:0031370 eukaryotic initiation factor 4G binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0016604 nuclear body;GO:0000932 P-body", "go_biological_process": "GO:0006417 regulation of translation;GO:0006413 translational initiation;GO:0006412 translation;GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P48598-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07436-1", "uniprot_id": "EXPA_DROME", "mass": 153644.0, "length": 1427, "protein_name": "Protein expanded", "gene_name": "ex", "organism": "Fruit fly", "refseq_name": "expanded, isoform B", "refseq_ac": "NP_001259823", "gene_names_uniprotkb": "ex; 1270; CG4114; Dmel\\CG4114; Dmel_CG4114; EX; Expanded; Ex; Frmd6; brl; exp; l(2)01270; l(2)ey", "gene_names_refseq": "1270; CG4114; Dmel\\CG4114; EX; Expanded; Ex; Frmd6; brl; exp; ex; l(2)01270; l(2)ey", "protein_names_uniprotkb": "Protein expanded", "protein_names_refseq": "CG4114-PB; braille; ex-PB; expanded, isoform B; expanded", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162); asthma (Disease Ontology:DOID:2841)", "pathway": " (dme:Dmel_CG4114); (R-DME-451806)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;19289086;19733165;20159598;25589440;26109356;26109357;26954546;27462444;8269855", "class_list": "", "function": "Activates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:20159598, PubMed:26954546, PubMed:27462444, PubMed:8269855). The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Ex acts synergistically along with Mer and Kibra to regulate the Hippo signaling pathway (PubMed:20159598). Involved in the control of cell proliferation in imaginal disks (PubMed:27462444, PubMed:8269855). May bind to certain proteins of signal transduction pathways by interaction with their SH3 domains (PubMed:20159598). Required for apical localization of Schip1 (PubMed:26954546)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VPQ0", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019900 kinase binding;GO:0140297 DNA-binding transcription factor binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0098592 cytoplasmic side of apical plasma membrane;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0016327 apicolateral plasma membrane;GO:0036375 Kibra-Ex-Mer complex", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0040008 regulation of growth;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q07436-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08630-1", "uniprot_id": "BTKL_DROME", "mass": 87392.0, "length": 786, "protein_name": "Tyrosine-protein kinase Btk", "gene_name": "Btk", "organism": "Fruit fly", "refseq_name": "bruton tyrosine kinase, isoform F", "refseq_ac": "NP_001097120", "gene_names_uniprotkb": "Btk; Btk29A; Btk29a; Btk29; C-src2; C-src4; CG18355; CG8049; CT2415; CT41718; DSrc28; DTec29; Dm SRC2; Dmel\\CG8049; Dmel_CG8049; Dsrc28C; Dsrc29A; EC2-9; S13; SRC 29A; Src29A; Src2; Tec29A; Tec29; Tec; btk29A; btk29a; btk29; btk; dsrc29A; fic; fps; src-4; src28C; src2; src4; tec29", "gene_names_refseq": "Btk29A; Btk29a; Btk29; Btk; C-src2; C-src4; CG18355; CG8049; CT2415; CT41718; DSrc28; DTec29; Dm SRC2; Dmel\\CG8049; Dsrc28C; Dsrc29A; EC2-9; S13; SRC 29A; Src29A; Src2; Tec29A; Tec29; Tec; btk29A; btk29a; btk29; btk; c-src/fps; dsrc29A; fic; src-4; src28C; src2; src4; tec29", "protein_names_uniprotkb": "Tyrosine-protein kinase Btk; 2.7.10.2; Dsrc28C; Dsrc29a", "protein_names_refseq": "Btk family kinase at 29A; Btk-PF; Btk29A type 2; CG8049-PF; Src oncogene 29A; bruton tyrosine kinase, isoform F; fickle", "tax_id": 7227, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); lymphoproliferative syndrome 1 (Disease Ontology:DOID:0060707); isolated growth hormone deficiency type III (Disease Ontology:DOID:0060875); COVID-19 (Disease Ontology:DOID:0080600); X-linked agammaglobulinemia (Disease Ontology:DOID:14179); arthus reaction (Disease Ontology:DOID:1556); agammaglobulinemia (Disease Ontology:DOID:2583); central nervous system lymphoma (Disease Ontology:DOID:3234); lung adenocarcinoma (Disease Ontology:DOID:3910); B-cell lymphoma (Disease Ontology:DOID:707); Burkitt lymphoma (Disease Ontology:DOID:8584); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG8049); (R-DME-111465); (R-DME-1660499); (R-DME-2424491); (R-DME-2871809); (R-DME-416476); (R-DME-416482); (R-DME-512988)", "pathway_count": 8, "publication_count": 18, "publication_id_list": "10330180;10731132;12537568;12537569;12537572;12537573;12537574;14976559;16110336;17569856;17569867;25589440;26109356;26109357;3110602;3923437;9655810;9660966", "class_list": "", "function": "Required for proper ring canal development. Also required for the development of male genitalia and for adult survival., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4V0F3;A4V0F4;O45032;O76132;O76133;P11361;Q6NNV0;Q8T0A0;Q9VLQ2;Q9VLQ3", "ec_number_list": "2.7.10.1;3.4.22.-;2.7.10.2;3.6.5.2;2.7.12.1;2.7.12.2;2.7.11.22;3.1.4.11;2.7.11.1", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0071944 cell periphery;GO:0045172 germline ring canal", "go_biological_process": "GO:0007254 JNK cascade;GO:0030036 actin cytoskeleton organization;GO:0048477 oogenesis;GO:0030833 regulation of actin filament polymerization;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P08630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48602-1", "uniprot_id": "VATA1_DROME", "mass": 68376.0, "length": 614, "protein_name": "V-type proton ATPase catalytic subunit A isoform 1", "gene_name": "Vha68-1", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase 68kD subunit 1, isoform B", "refseq_ac": "NP_001260426", "gene_names_uniprotkb": "Vha68-1; A subunit; ATP6V1A; CG12403; Dmel\\CG12403; Dmel_CG12403; Vha-68-1; Vha68; VhaA; Vhaa1; Vha; vha67-1; vha68-1", "gene_names_refseq": "A subunit; ATP6V1A; CG12403; Dmel\\CG12403; Vha-68-1; Vha68-1; Vha68; VhaA; Vha; vha67-1; vha68-1", "protein_names_uniprotkb": "V-type proton ATPase catalytic subunit A isoform 1; 7.1.2.2; V-ATPase 69 kDa subunit 1; V-ATPase subunit A 1; Vacuolar proton pump subunit alpha 1", "protein_names_refseq": "CG12403-PB; V-ATPase V1 subunit A1; Vha68-1-PB; vacuolar ATPase subunit A; vacuolar H[+] ATPase 68kD subunit 1, isoform B; vacuolar H[+] ATPase subunit 68-1; vacuolar H[+]-ATPase 68kD A subunit; vacuolar H[+]-ATPase 68; vacuolar H[+]-ATPase A subunit", "tax_id": 7227, "disease": "autosomal recessive cutis laxa type IID (Disease Ontology:DOID:0070129); developmental and epileptic encephalopathy 93 (Disease Ontology:DOID:0112275)", "pathway": " (dme:Dmel_CG12403)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9050231", "class_list": "", "function": "Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q541D0;Q9V3M7", "ec_number_list": "7.1.2.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180 proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0046034 ATP metabolic process;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P48602-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40798-1", "uniprot_id": "STC_DROME", "mass": 123183.0, "length": 1106, "protein_name": "Protein shuttle craft", "gene_name": "stc", "organism": "Fruit fly", "refseq_name": "shuttle craft, isoform A", "refseq_ac": "NP_476598", "gene_names_uniprotkb": "stc; 151662_s_at; BG:DS04929.4; BcDNA.LD22726; BcDNA:LD22726; CG3647; Cf4; Dmel\\CG3647; Dmel_CG3647; LD22726; br33; l(2)35Cb; l(2)SH1565; l(2)SH2 1565; l(2)br33; l35Cb", "gene_names_refseq": "151662_s_at; BG:DS04929.4; BcDNA.LD22726; BcDNA:LD22726; CG3647; Cf4; Dmel\\CG3647; LD22726; br33; l(2)35Cb; l(2)SH1565; l(2)SH2 1565; l(2)br33; l35Cb; stc", "protein_names_uniprotkb": "Protein shuttle craft", "protein_names_refseq": "CG3647-PA; Chorion-factor-4; shuttle craft, isoform A; shuttlecraft; stc-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3647)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10471707;10731132;10731138;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8524296", "class_list": "", "function": "Plays an essential role during the late stages of embryonic neurogenesis. May either fine-tune the guidance or the spatial maintenance of the migrating SNB and in nerve roots, which are composed of axons originating from distinct groups of motor neurons and may be required to either guide or maintain the position of these nerves along a direct and straight path to their ultimate targets in particular muscle fields. May play a role in egg chamber development and/or may confer essential maternal contributions to the early embryo., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IP49;Q9VJQ1;Q9Y0Z5", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03017-1", "uniprot_id": "CACT_DROME", "mass": 53818.0, "length": 500, "protein_name": "NF-kappa-B inhibitor cactus", "gene_name": "cact", "organism": "Fruit fly", "refseq_name": "cactus, isoform E", "refseq_ac": "NP_001260496", "gene_names_uniprotkb": "cact; 5848; BG:DS02740.15; CACTUS; CACT; CG5848; Cactus; Cact; Dmel\\CG5848; Dmel_CG5848; Ikappa; NFkappabeta1A; cac; dip6; fs(2)ltoRN48; n(2)k17003", "gene_names_refseq": "5848; BG:DS02740.15; CACTUS; CACT; CG5848; Cactus; Cact; Dmel\\CG5848; Ikappa; NFkappabeta1A; cact; cac; dip6; fs(2)ltoRN48; n(2)k17003", "protein_names_uniprotkb": "NF-kappa-B inhibitor cactus", "protein_names_refseq": "CG5848-PE; NF-kappa-B inhibitor cactus; cact-PE; cactus, isoform E; female-sterile-(2)-ltoRN48", "tax_id": 7227, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); childhood-onset asthma (Disease Ontology:DOID:0080815); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); ectodermal dysplasia and immunodeficiency 2 (Disease Ontology:DOID:0081079); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); nephrotic syndrome (Disease Ontology:DOID:1184); alcoholic hepatitis (Disease Ontology:DOID:12351); Sjogren's syndrome (Disease Ontology:DOID:12894); lung cancer (Disease Ontology:DOID:1324); diarrhea (Disease Ontology:DOID:13250); toxic shock syndrome (Disease Ontology:DOID:14115); hepatitis C (Disease Ontology:DOID:1883); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); transient cerebral ischemia (Disease Ontology:DOID:224); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometriosis (Disease Ontology:DOID:289); pulmonary tuberculosis (Disease Ontology:DOID:2957); glioblastoma (Disease Ontology:DOID:3068); atopic dermatitis (Disease Ontology:DOID:3310); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastritis (Disease Ontology:DOID:4029); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); collagen disease (Disease Ontology:DOID:854); Hodgkin's lymphoma (Disease Ontology:DOID:8567); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); encephalitis (Disease Ontology:DOID:9588); pulmonary emphysema (Disease Ontology:DOID:9675); toxoplasmosis (Disease Ontology:DOID:9965)", "pathway": " (dme:Dmel_CG5848); (R-DME-1169091); (R-DME-1810476); (R-DME-202424); (R-DME-209406); (R-DME-209560); (R-DME-214842); (R-DME-214844); (R-DME-214869); (R-DME-2871837); (R-DME-445989); (R-DME-5607764); (R-DME-9020702); (R-DME-933542); (R-DME-9860927)", "pathway_count": 15, "publication_count": 29, "publication_id_list": "10072384;10471707;10636911;10657303;10660298;10731132;10842059;11532919;12537568;12537569;12537572;12537573;12537574;12973300;1423618;1423619;16110336;17569856;17569867;25589440;26109356;26109357;7705656;8948598;9025065;9367441;9405646;9553105;9990853", "class_list": "", "function": "Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0S3;Q0E8Q3;Q9V3M6", "ec_number_list": "", "go_molecular_function": "GO:0051059 NF-kappaB binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0071212 subsynaptic reticulum", "go_biological_process": "GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0009953 dorsal/ventral pattern formation;GO:0019730 antimicrobial humoral response;GO:0048477 oogenesis;GO:0009950 dorsal/ventral axis specification", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q03017-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09085-1", "uniprot_id": "CAD_DROME", "mass": 45726.0, "length": 427, "protein_name": "Homeotic protein caudal", "gene_name": "cad", "organism": "Fruit fly", "refseq_name": "caudal, isoform A", "refseq_ac": "NP_476954", "gene_names_uniprotkb": "cad; 38E.19; CAD; CG1759; Cadf; Cad; Caudal; Dm-Cad; Dmel\\CG1759; Dmel_CG1759; S67; anon-WO2004063362.83; cd", "gene_names_refseq": "38E.19; CAD; CG1759; Cadf; Cad; Caudal; Dm-Cad; Dmel\\CG1759; S67; anon-WO2004063362.83; cad; cd", "protein_names_uniprotkb": "Homeotic protein caudal", "protein_names_refseq": "CAUDAL; CG1759-PA; cad-PA; caudal, isoform A", "tax_id": 7227, "disease": "Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (dme:Dmel_CG1759)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10731132;12466526;12537568;12537569;12537572;12537573;12537574;15254275;16110336;16453641;17569856;17569867;18327897;2433048;25589440;26109356;26109357;7743918;9609826", "class_list": "", "function": "Caudal (cad) is one of a number of transcription factors controlling segmentation of the embryo. Further transcriptional regulation via a 5' flanking region containing DNA replication-related elements (DRE) and by dref also regulated by trh and tgo via the CNS midline element. Alongside Bicoid (bcd), caudal forms concentration gradients down the anterior-posterior (A-P) axis providing positional information and subsequent induction of the gap genes. Plays a role in gastrulation/germ band extension, hindgut morphogenesis, positive regulation of cell proliferation, genital disk development and pattern formation. Acts as a key regulator of the Hox gene network and activates transcription via the downstream core promoter element (DPE) relative to the TATA box. Plays a role in the establishment of the hindgut and in the invagination of the hindgut primordium during gastrulation. These effects on the gut are achieved by acting combinatorially at the posterior of the embryo to activate transcription of different targets including fog, fkh and wg. Caudal is involved in regulation of proliferation through transactivation of the E2F gene. Postembryonically its function is mostly restricted to the intestine where it regulates antimicrobial peptide (AMP) levels preserving the normal gut flora., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0Y1;D4G7D2;Q9VIJ6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007442 hindgut morphogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P09085-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q94519-1", "uniprot_id": "ACPM_DROME", "mass": 17263.0, "length": 152, "protein_name": "Acyl carrier protein, mitochondrial", "gene_name": "ND-ACP", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase (ubiquinone) acyl carrier protein, isoform B", "refseq_ac": "NP_477002", "gene_names_uniprotkb": "ND-ACP; ACPM; CG9160; Dmel\\CG9160; Dmel_CG9160; MTACP1A; MTACP1B; ND-AcC; NDUFAB1; dNDUFAB1; l(3)1303; l(3)j4A6; mtACP1A; mtACP1B; mtACP1; mtACP; mtacp1; mtacp", "gene_names_refseq": "ACPM; CG9160; Dmel\\CG9160; MTACP1A; MTACP1B; ND-ACP; ND-AcC; NDUFAB1; dNDUFAB1; l(3)1303; l(3)j4A6; mtACP1A; mtACP1B; mtACP1; mtACP; mtacp1; mtacp", "protein_names_uniprotkb": "Acyl carrier protein, mitochondrial; ACP; NADH dehydrogenase (ubiquinone) acyl carrier protein; NADH-ubiquinone oxidoreductase 9.6 kDa subunit; NADH-ubiquinone oxidoreductase acyl-carrier subunit; mtACP", "protein_names_refseq": "CG9160-PB; NADH dehydrogenase (ubiquinone) acyl carrier protein, isoform B; NADH ubiquinone oxidoreductase ACP; NADH ubiquinone oxidoreductase acyl carrier protein; NADH-ubiquinone oxidoreductase acyl carrier protein; NADH-ubiquinone oxidoreductase acyl-carrier subunit; NADH:ubiquinone oxidoreductase acyl carrier; ND-ACP-PB; mitochondrial acyl carrier protein 1; mitochondrial acyl carrier protein of electron transport complex I; mitochondrial acyl carrier protein", "tax_id": 7227, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734)", "pathway": " (dme:Dmel_CG9160); (R-DME-611105); (R-DME-6799198); (R-DME-77289); (R-DME-9857492)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10071211;10394906;10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Carrier of the growing fatty acid chain in fatty acid biosynthesis., [UniProtKB, UniProtKB]; Carrier of the growing fatty acid chain in fatty acid biosynthesis. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B2AKC6;Q94520;Q9W0G8;Q9W0G9", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0000035 acyl binding;GO:0000036 acyl carrier activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I;GO:0099128 mitochondrial [2Fe-2S] assembly complex;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0044571 [2Fe-2S] cluster assembly;GO:1902600 proton transmembrane transport;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q94519-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8T0D4-1", "uniprot_id": "TANT_DROME", "mass": 33766.0, "length": 299, "protein_name": "Protein tantalus", "gene_name": "tant", "organism": "Fruit fly", "refseq_name": "tantalus, isoform B", "refseq_ac": "NP_001261460", "gene_names_uniprotkb": "tant; CG6586; Dmel\\CG6586; Dmel_CG6586; Tan; tan", "gene_names_refseq": "CG6586; Dmel\\CG6586; Tan; tant; tan", "protein_names_uniprotkb": "Protein tantalus", "protein_names_refseq": "CG6586-PB; tant-PB; tantalus, isoform B; tantalus", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6586)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;11397012;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;40245499", "class_list": "", "function": "Potential cofactor involved in sensory organ development. Despite its interaction with the Polycomb group protein Asx, it does not regulate the expression of homeotic genes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9NHW6;Q9VRT0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0007423 sensory organ development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8T0D4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07327-1", "uniprot_id": "ROP_DROME", "mass": 67851.0, "length": 597, "protein_name": "Protein ROP", "gene_name": "Rop", "organism": "Fruit fly", "refseq_name": "Ras opposite, isoform B", "refseq_ac": "NP_001261404", "gene_names_uniprotkb": "Rop; CG15811; Dmel\\CG15811; Dmel_CG15811; ROP; SEC1; Unc18; cs1; l(3)64Ah; l(3)SH16; ras2; rop(Sec1); rop; sec1", "gene_names_refseq": "CG15811; Dmel\\CG15811; ROP; Rop; SEC1; Unc18; cs1; l(3)64Ah; l(3)SH16; ras2; rop(Sec1); rop; sec1", "protein_names_uniprotkb": "Protein ROP", "protein_names_refseq": "CG15811-PB; Ras opposite, isoform B; Rop-PB; ras opposite", "tax_id": 7227, "disease": "West syndrome (Disease Ontology:DOID:0050562); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 4 (Disease Ontology:DOID:0080436); familial hemophagocytic lymphohistiocytosis 5 (Disease Ontology:DOID:0110925); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG15811); (R-DME-114516); (R-DME-114608); (R-DME-181429); (R-DME-181430); (R-DME-210500); (R-DME-212676); (R-DME-264642); (R-DME-449836); (R-DME-888590)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7917291;8404533", "class_list": "", "function": "May be a component of one of the vesicle trafficking pathways. May interact functionally with Ras2 protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24010;Q9VZH8", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030141 secretory granule", "go_biological_process": "GO:1990182 exosomal secretion;GO:0006886 intracellular protein transport;GO:0032940 secretion by cell;GO:0007268 chemical synaptic transmission;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q07327-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46867-1", "uniprot_id": "KLP68_DROME", "mass": 88207.0, "length": 784, "protein_name": "Kinesin-like protein Klp68D", "gene_name": "Klp68D", "organism": "Fruit fly", "refseq_name": "Kinesin-like protein at 68D, isoform B", "refseq_ac": "NP_001261726", "gene_names_uniprotkb": "Klp68D; 68D]]; CG7293; DmKlp68D; Dmel\\CG7293; Dmel_CG7293; KIF 3B; KIF3B; KLP-5; KLP5; KLP68Ddm; KLP68D; Klp5; klp68d", "gene_names_refseq": "CG7293; DmKlp68D; Dmel\\CG7293; KIF 3B; KIF3B; KLP-5; KLP5; KLP68Ddm; KLP68D; KLP[[64D/68D]]; Klp5; Klp68D; klp68d", "protein_names_uniprotkb": "Kinesin-like protein Klp68D", "protein_names_refseq": "CG7293-PB; Kinesin-2; Kinesin-like protein at 68D, isoform B; Kinesin1; Klp68D-PB; kinesin II", "tax_id": 7227, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); retinitis pigmentosa 89 (Disease Ontology:DOID:0112146); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG7293); (R-DME-983189)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;1924306;25589440;26109356;26109357;7525600", "class_list": "", "function": "Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q961H5;Q9VTN8", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0005875 microtubule associated complex;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0008089 anterograde axonal transport;GO:0007608 sensory perception of smell;GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P46867-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27403-1", "uniprot_id": "GCM_DROME", "mass": 56202.0, "length": 504, "protein_name": "Transcription factor glial cells missing", "gene_name": "gcm", "organism": "Fruit fly", "refseq_name": "glial cells missing, isoform B", "refseq_ac": "NP_001260292", "gene_names_uniprotkb": "gcm; CG12245; Dmel\\CG12245; Dmel_CG12245; GCM1; GCMa; GCM; Gcm; N7-4; gcm; glide; l(2)N7-4; ucc", "gene_names_refseq": "CG12245; Dmel\\CG12245; GCM1; GCMa; GCM; Gcm; N7-4; gcm; glide/gcm; glide; l(2)N7-4; ucc", "protein_names_uniprotkb": "Transcription factor glial cells missing; Protein glide", "protein_names_refseq": "CG12245-PB; gcm-PB; glia cells missing; glial cell deficient; glial cell missing; glial cells missing, isoform B; glial cells-missing; glide glide2; glide; upper class chordotonals", "tax_id": 7227, "disease": "familial isolated hypoparathyroidism 2 (Disease Ontology:DOID:0061151); hypoparathyroidism (Disease Ontology:DOID:11199); hyperparathyroidism (Disease Ontology:DOID:13543); infertility (Disease Ontology:DOID:5223)", "pathway": " (dme:Dmel_CG12245)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7553843;7553844;9356176", "class_list": "", "function": "Transcription factor that induces gliogenesis. It determines the choice between glial and neuronal fates. Also has a role in the differentiation of the plasmatocyte/macrophage lineage of hemocytes., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AVW8;Q9VLA5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045687 positive regulation of glial cell differentiation;GO:0021782 glial cell development;GO:0060252 positive regulation of glial cell proliferation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q27403-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95RI5-1", "uniprot_id": "FAXC_DROME", "mass": 47105.0, "length": 418, "protein_name": "Failed axon connections", "gene_name": "fax", "organism": "Fruit fly", "refseq_name": "failed axon connections, isoform A", "refseq_ac": "NP_524106", "gene_names_uniprotkb": "fax; CG4609; Dmel\\CG4609; Dmel_CG4609; FAX; Fax; anon-EST:Liang-1.34; anon-WO0172774.62; anon-WO0172774.63; anon-WO0172774.65; anon-WO0172774.66; anon-WO0172774.67; anon-WO0172774.68; anon-WO0172774.69; clone 1.34; fac", "gene_names_refseq": "CG4609; Dmel\\CG4609; FAX; Fax; anon-EST:Liang-1.34; anon-WO0172774.62; anon-WO0172774.63; anon-WO0172774.65; anon-WO0172774.66; anon-WO0172774.67; anon-WO0172774.68; anon-WO0172774.69; clone 1.34; fac; fax", "protein_names_uniprotkb": "Failed axon connections", "protein_names_refseq": "CG4609-PA; failed axon connections, isoform A; failed axon connections; failed axonal connections; fax-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4609)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8647396", "class_list": "", "function": "Together with Abl, involved in embryonic axonal development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VV57", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0036099 female germ-line stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q95RI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18537-1", "uniprot_id": "FRIZ_DROME", "mass": 64847.0, "length": 581, "protein_name": "Frizzled", "gene_name": "fz", "organism": "Fruit fly", "refseq_name": "frizzled, isoform A", "refseq_ac": "NP_524812", "gene_names_uniprotkb": "fz; CG17697; CG3646; DFZ1; DFz1; DFz; Dfz1; Dfz; Dm Fz1; Dmel\\CG17697; Dmel_CG17697; FZ1; FZ; Frizzled; Frz; Fz1; Fzd; Fz; dFz; frz; fz1; fz[[1]]", "gene_names_refseq": "CG17697; CG3646; DFZ1; DFz1; DFz; Dfz1; Dfz; Dm Fz1; Dmel\\CG17697; FZ1; FZ; Frizzled; Frz; Fz1; Fzd; Fz; dFz; frz; fz1; fz[[1]]; fz", "protein_names_uniprotkb": "Frizzled; Frizzled-1; dFz1", "protein_names_refseq": "CG17697-PA; Frizzled1; frizzed; frizzled 1; frizzled, isoform A; frizzled[[1]]; frizzled; fz-PA", "tax_id": 7227, "disease": "omodysplasia 2 (Disease Ontology:DOID:0080845); leiomyoma (Disease Ontology:DOID:127); nephroblastoma (Disease Ontology:DOID:2154); breast carcinoma (Disease Ontology:DOID:3459); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG17697); (R-DME-209387); (R-DME-209440); (R-DME-209472); (R-DME-350368); (R-DME-350376); (R-DME-350379); (R-DME-350411); (R-DME-350480); (R-DME-4086400); (R-DME-450728); (R-DME-4608870); (R-DME-4641262); (R-DME-5140745)", "pathway_count": 14, "publication_count": 58, "publication_id_list": "10196136;10360843;10421629;10469646;10490098;10570971;10731132;10846164;10949033;11301004;11336703;11874917;11893338;12015972;12205098;12506006;12537568;12537569;12537572;12537573;12537574;12540853;12636921;12642492;12756182;12781135;12941693;14636582;14731402;15240556;15269282;15459103;15556868;15937478;16110336;16163385;16341016;16469972;16687445;16987508;17569856;17569867;18555784;18701542;18723886;18804371;18849982;19576201;20579883;2174014;2493583;25589440;26109356;26109357;38381787;8717036;9694801;9716412", "class_list": "", "function": "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUE0;Q9VUE2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007494 midgut development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0045773 positive regulation of axon extension;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "P18537-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25439-1", "uniprot_id": "BRM_DROME", "mass": 185089.0, "length": 1638, "protein_name": "Brahma chromatin-remodeling complex ATPase subunit", "gene_name": "brm", "organism": "Fruit fly", "refseq_name": "brahma, isoform C", "refseq_ac": "NP_536745", "gene_names_uniprotkb": "brm; BRD; BRM; Brahma; Brg; Brm @ Kto; Brm; CG18438; CG5942; Dmel\\CG5942; Dmel_CG5942; E(E2F)3A; dBRM; dSMARCA4; dSNF2; l(3)72Aa", "gene_names_refseq": "BRD; BRM; Brahma; Brg; Brm @ Kto; Brm; CG18438; CG5942; Dmel\\CG5942; E(E2F)3A; brm; dBRM; dSMARCA4; dSNF2; l(3)72Aa", "protein_names_uniprotkb": "Brahma chromatin-remodeling complex ATPase subunit; 3.6.4.-; Homeotic gene regulator; Protein brahma", "protein_names_refseq": "CG5942-PC; brahma, isoform C; brahma; brm-PC; complementation group 3.5", "tax_id": 7227, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); rhabdoid tumor predisposition syndrome 2 (Disease Ontology:DOID:0060997); Coffin-Siris syndrome 4 (Disease Ontology:DOID:0070046); Nicolaides-Baraitser syndrome (Disease Ontology:DOID:0081441); blepharophimosis-impaired intellectual development syndrome (Disease Ontology:DOID:0081442); prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG5942); (R-DME-1266695); (R-DME-3214858); (R-DME-3247509); (R-DME-8939243); (R-DME-9764725); (R-DME-9933937); (R-DME-9933939); (R-DME-9933946); (R-DME-9933947); (R-DME-9934037)", "pathway_count": 11, "publication_count": 18, "publication_id_list": "10601025;10731132;10809665;12381660;12537568;12537569;12537572;12537573;12537574;1346755;16110336;17569856;17569867;18327897;24618901;25589440;26109356;26109357", "class_list": "", "function": "Transcriptional regulator (PubMed:1346755). Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters (PubMed:1346755). Can counteract the repressive effect of Polycomb protein (PubMed:1346755). ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA (PubMed:1346755). This complex can both serve as a transcriptional coactivator or corepressor, depending on the context (PubMed:10809665). In type II neuroblast lineage, as part of the Brm remodeling complex, suppresses the formation of ectopic neuroblasts probably through interaction with erm and HDAC3 (PubMed:24618901)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4V1Z7;A4V1Z8;Q9VUW5;Q9VUW6", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;2.1.1.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035060 brahma complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P25439-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08605-1", "uniprot_id": "GAGA_DROME", "mass": 62599.0, "length": 582, "protein_name": "Transcription activator GAGA", "gene_name": "Trl", "organism": "Fruit fly", "refseq_name": "Trithorax-like, isoform H", "refseq_ac": "NP_001034014", "gene_names_uniprotkb": "Trl; Adf-2-519; Adf-2; Adf2; CG33261; CG9343; Dmel\\CG33261; Dmel_CG33261; E(var)3-trl; E(var)62; GAF; GAGA factor; GAGA; Gaf; Gaga; LBC; NC70F; Nc70F; TFGAGA; TRL; Trl-GAGA; Try; anon-EST:fe2E12; gaf; gaga; l(3)s2325; trithorax-like; trl", "gene_names_refseq": "Adf-2-519; Adf-2; Adf2; CG33261; CG9343; Dmel\\CG33261; E(var)3-trl; E(var)62; GAF; GAGA factor; GAGA; Gaf; Gaga; LBC; NC70F; Nc70F; TRL; TfGAGA/Adf-2; Trl-GAGA; Trl; Try; anon-EST:fe2E12; gaf; gaga; l(3)s2325; trithorax-like; trl", "protein_names_uniprotkb": "Transcription activator GAGA; Adh transcription factor 2; GAF; GAGA factor; Neural conserved at 70F; Trithorax-like protein", "protein_names_refseq": "Adh transcription factor 2; CG33261-PH; GAGA element; GAGA factor; GAGA transcription factor; GAGA-factor; Trithorax-like, isoform H; Trithorax-related; Trithroax-like; Trl-PH; anon-fast-evolving-2E12; late boundary complex; neural conserved at 70F; transcription-factor-Adh2; trithorax like; trithorax-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33261)", "pathway_count": 1, "publication_count": 39, "publication_id_list": "10347208;10731132;10764754;11256608;11421119;11583616;12200449;12384587;12537568;12537569;12537572;12537573;12537574;12601174;12771214;12815073;12834867;15020425;15063171;16023138;16110336;17569856;17569867;18327897;18614012;25589440;26109356;26109357;26335634;28366641;28676122;33720012;7504178;7935842;8107823;8307350;8620838;9033593;9241251", "class_list": "", "function": "Transcriptional activator that functions by regulating chromatin structure (PubMed:12815073, PubMed:15063171, PubMed:28676122, PubMed:33720012, PubMed:7504178, PubMed:7935842, PubMed:8107823, PubMed:9241251). Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors (PubMed:26335634, PubMed:28676122, PubMed:33720012, PubMed:8107823). Required for nucleosome loss and chromatin remodeling at the Hsp70 locus upon heat shock (PubMed:18614012). Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones (PubMed:12815073, PubMed:12834867). Involved in zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:26335634, PubMed:28676122, PubMed:33720012). Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3' (PubMed:10347208, PubMed:12601174, PubMed:7504178, PubMed:9241251). Binds DNA as an oligomer (PubMed:10347208, PubMed:12601174, PubMed:7504178, PubMed:9241251). May also act as a transcriptional repressor, maintaining the repressed state of genes including lolal, and down-regulating its own transcription (PubMed:12200449). Required for dosage compensation in males and may be involved in oogenesis (PubMed:15020425). Also has a role in nuclear division (PubMed:8620838)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1Y6;A4V1Y7;O18349;O18350;O18526;Q08083;Q7JN57;Q8MYL3;Q8T387;Q9V3X7;Q9VUH2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0032991 protein-containing complex;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q08605-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61209-1", "uniprot_id": "ARF1_DROME", "mass": 20688.0, "length": 182, "protein_name": "ADP-ribosylation factor 1", "gene_name": "Arf1", "organism": "Fruit fly", "refseq_name": "ADP ribosylation factor 1, isoform F", "refseq_ac": "NP_001097667", "gene_names_uniprotkb": "Arf1; ARF-1; ARF1_DROME; ARF1; Arf79F; Arf79f; Arf79; Arf; CG8385; Darf1; Dm Arf79F; Dmel\\CG8385; Dmel_CG8385; P61209; arf1; d-Arf1; dARF79F; dARFI; dArf1; dArf79F", "gene_names_refseq": "ARF-1; ARF1_DROME; ARF1; Arf1; Arf79F; Arf79f; Arf79; Arf; CG8385; Darf1; Dm Arf79F; Dmel\\CG8385; P61209; arf1; d-Arf1; dARF79F; dARFI; dArf1; dArf79F", "protein_names_uniprotkb": "ADP-ribosylation factor 1; 3.6.5.2", "protein_names_refseq": "ADP ribosylation factor 1, isoform F; ADP ribosylation factor 79F; ADP ribosylation factor at 79F; ADP-ribosylation factor 1; Arf1-PF; CG8385-PF", "tax_id": 7227, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454)", "pathway": " (dme:Dmel_CG8385); (R-DME-1660499); (R-DME-1660514); (R-DME-199992); (R-DME-432720); (R-DME-432722); (R-DME-6807878); (R-DME-6811434); (R-DME-6811438); (R-DME-9845576)", "pathway_count": 10, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;21976699;25589440;26109356;26109357;27535433;8507638", "class_list": "", "function": "GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus., [UniProtKB, UniProtKB]; Small GTPase involved in protein trafficking between different compartments. Modulates vesicle budding and uncoating within the Golgi complex. In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Has a role in eye development (PubMed:21976699). Required for cleavage furrow ingression in embryonic cells (PubMed:27535433)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2B1;A8JNX4;P35676;Q9VNQ2", "ec_number_list": "3.6.5.5;3.1.3.1;3.6.5.2;3.6.5.-;3.1.3.56;3.6.5.3;3.1.22.1;2.3.1.225", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0032011 ARF protein signal transduction;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016192 vesicle-mediated transport;GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P61209-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18490-1", "uniprot_id": "PCX_DROME", "mass": 365325.0, "length": 3413, "protein_name": "Protein pecanex", "gene_name": "pcx", "organism": "Fruit fly", "refseq_name": "pecanex, isoform C", "refseq_ac": "NP_001259182", "gene_names_uniprotkb": "pcx; CG3443; DMPCX; Dmel\\CG3443; Dmel_CG3443; EG:30B8.4; fs(1)12-1012; fs(1)12-1743; fs(1)12-2135; fs(1)12-3014; fs(1)12-3102; fs(1)12-4169; fs(1)14-1153; fs(1)14-567; fs(1)A387; fs(1)M10; fs(1)pcx; mel(1)R1; mel(1)R", "gene_names_refseq": "CG3443; DMPCX; Dmel\\CG3443; EG:30B8.4; fs(1)12-1012; fs(1)12-1743; fs(1)12-2135; fs(1)12-3014; fs(1)12-3102; fs(1)12-4169; fs(1)14-1153; fs(1)14-567; fs(1)A387; fs(1)M10; fs(1)pcx; mel(1)R1; mel(1)R; pcx", "protein_names_uniprotkb": "Protein pecanex", "protein_names_refseq": "CG3443-PC; pcx-PC; pecanex, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3443)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;2478400;25589440;26109356;26109357", "class_list": "", "function": "Involved in neurogenesis., [UniProtKB]", "predicted_glycosites": 24, "predicted_n_glycosites": 21, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "O46074;Q95TI6;Q9W506", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P18490-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34082-1", "uniprot_id": "FAS2_DROME", "mass": 96926.0, "length": 873, "protein_name": "Fasciclin-2", "gene_name": "Fas2", "organism": "Fruit fly", "refseq_name": "fasciclin 2, isoform A", "refseq_ac": "NP_525066", "gene_names_uniprotkb": "Fas2; 1D4; Ab 1D4; CG3665; CT12301; Dmel\\CG3665; Dmel_CG3665; EG:EG0007.3; FAS 11; FAS II; FAS2; FASII; Fas 2; Fas II; Fas-II; FasII; Fasc II; FascII; Fasii; Fas; MAB1D4; anon-EST:Liang-1.60; clone 1.60; fas II; fas-II; fas2; fasII; fasciclin II; l(1)G0032; l(1)G0048; l(1)G0081; l(1)G0293; l(1)G0336; mAB1D4; mAb 1D4; mAb1D4", "gene_names_refseq": "1D4; Ab 1D4; CG3665; CT12301; Dmel\\CG3665; EG:EG0007.3; FAS 11; FAS II; FAS2; FASII; Fas 2; Fas II; Fas-II; Fas2; FasII; Fasc II; FascII; Fasii; Fas; MAB1D4; anon-EST:Liang-1.60; clone 1.60; fas II; fas-II; fas2; fasII; fasciclin II; l(1)G0032; l(1)G0048; l(1)G0081; l(1)G0293; l(1)G0336; mAB1D4; mAb 1D4; mAb1D4", "protein_names_uniprotkb": "Fasciclin-2; FAS II; Fasciclin II", "protein_names_refseq": "CG3665-PA; FASCICLIN II; Fas2-PA; FasciclinII; fasII; fascicilin II; fasciclin 2, isoform A; fasciclin 2; fasciclin-2; fasciclin-II; fasciclin2; fasciculin II; fascilin II; fasiclin II", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); ovarian serous carcinoma (Disease Ontology:DOID:0050933); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); morphine dependence (Disease Ontology:DOID:2560); brain glioblastoma multiforme (Disease Ontology:DOID:3073); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); adenoma (Disease Ontology:DOID:657); type 1 diabetes mellitus (Disease Ontology:DOID:9744); drug dependence (Disease Ontology:DOID:9974)", "pathway": " (dme:Dmel_CG3665); (R-DME-1474228); (R-DME-210991); (R-DME-216083); (R-DME-428542); (R-DME-433692); (R-DME-9749641)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537572;12537573;12537574;16110336;17569856;17569867;17893096;18327897;1913818;25589440;26109356;26109357", "class_list": "", "function": "Neuronal recognition molecule for the MP1 axon pathway, pathway recognition for axons during the development of nerve fascicles., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P34083;Q6IDE4;Q8IRS5;Q9W4M6", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030426 growth cone;GO:0031594 neuromuscular junction", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0072553 terminal button organization;GO:0007528 neuromuscular junction development;GO:0007611 learning or memory;GO:0050803 regulation of synapse structure or activity", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P34082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27884-1", "uniprot_id": "PPP6_DROME", "mass": 34759.0, "length": 303, "protein_name": "Serine/threonine-protein phosphatase 6 catalytic subunit", "gene_name": "PpV", "organism": "Fruit fly", "refseq_name": "protein phosphatase V, isoform B", "refseq_ac": "NP_001259272", "gene_names_uniprotkb": "PpV; CG12217; DmPpV-6A; Dmel\\CG12217; Dmel_CG12217; PP6; PPPV6A; PPV 6A; PPV; PpV[[C]]; Ppv; dPP6; ppv", "gene_names_refseq": "CG12217; DmPpV-6A; Dmel\\CG12217; PP6; PPPV6A; PPV 6A; PPV; PpV[[C]]; PpV; Ppv; dPP6; ppv", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 6 catalytic subunit; 3.1.3.16; PP-V; PP6C; Phosphatase V", "protein_names_refseq": "CG12217-PB; PpV-PB; protein phosphatase V, isoform B; protein phosphatase V", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12217)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8223492", "class_list": "", "function": "May be involved in controlling cellularization or in regulating transcription of the genes involved in this process., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIJ4;Q8MRZ7;Q9W3Z8", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.27;3.1.3.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:0046329 negative regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q27884-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19339-1", "uniprot_id": "SXL_DROME", "mass": 38549.0, "length": 354, "protein_name": "Protein sex-lethal", "gene_name": "Sxl", "organism": "Fruit fly", "refseq_name": "Sex lethal, isoform O", "refseq_ac": "NP_001027062", "gene_names_uniprotkb": "Sxl; CG14425; CG18350; CG33070; CG43770; Dm-Sxl; DmSxl; Dmel\\CG43770; Dmel_CG43770; Fl; Mex156; ORF2; SXL; Su(da); Sx1; SxL; Sxl-1 Sxl-2; Sxl-Pe; SxlPe; SxlPm; dSXL; fs(1)K1274; fs(1)M106; l(1)6Fa; melSxl; sxl", "gene_names_refseq": "CG14425; CG18350; CG33070; CG43770; Dm-Sxl; DmSxl; Dmel\\CG43770; Fl; Mex156; ORF2; SXL; Su(da); Sx1; SxL; Sxl-1 Sxl-2; Sxl-Pe; SxlPe; SxlPm; Sxl; dSXL; fs(1)K1274; fs(1)M106; l(1)6Fa; melSxl; sxl", "protein_names_uniprotkb": "Protein sex-lethal", "protein_names_refseq": "CG43770-PO; Sex lethal, isoform O; Sex lethal; Sex-kethal; Sxl-PO; female lethal; sex-lethal; sexlethal", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43770)", "pathway_count": 1, "publication_count": 40, "publication_id_list": "10217141;10545124;10617208;10731132;12444081;12537568;12537572;12537573;12537574;12769862;14532129;1454517;1547493;16110336;16122421;16452508;16452509;1690860;1710769;17569856;17569867;18203923;19941818;23526974;23788626;2503251;25209665;25589440;26109356;26109357;26324914;3144435;40215271;7516476;7524663;7680770;8978052;9144292;9182767;9299339", "class_list": "", "function": "Embryo-specific product, which is expressed early only in female embryos and specifies female-adult specific splicing., [UniProtKB, PubMed]; Sex determination switch protein, which controls sexual development and dosage compensation in females (PubMed:10617208, PubMed:1547493, PubMed:1690860, PubMed:1710769, PubMed:19941818, PubMed:2503251, PubMed:25209665, PubMed:3144435, PubMed:7680770). Sxl protein is only active in females: it is inactive in males throughout development (PubMed:1547493, PubMed:1710769, PubMed:3144435). Acts as a mRNA-binding protein, which specifically binds to a subset of pre-mRNAs and mRNAs and regulates their processing and/or translation (PubMed:10217141, PubMed:10617208, PubMed:1690860, PubMed:19941818, PubMed:2503251, PubMed:7516476, PubMed:7680770). Binds nanos mRNA and is involved in bam-bgcn mediated repression of nanos mRNA translation (PubMed:23526974). Promotes sexual development by controlling the female-specific alternative splicing of the transformer (tra) pre-mRNA: binds tightly to a characteristic uridine-rich polypyrimidine tract at the non-sex specific 3' splice site in one of the tra introns, preventing the general splicing factor U2AF from binding to this site and forcing it to bind to the female-specific 3' splice site (PubMed:10217141, PubMed:1690860, PubMed:2503251, PubMed:7680770). Acts as an inhibitor of dosage compensation in females by preventing production of msl-2 protein, an essential component of the MSL complex, the complex that mediates X-chromosome dosage compensation (PubMed:10545124, PubMed:10617208, PubMed:12769862, PubMed:16452508, PubMed:16452509, PubMed:19941818, PubMed:23788626, PubMed:25209665, PubMed:9144292, PubMed:9182767). Specifically binds to uridine stretches in both the 5'- and 3'-UTR of msl-2 transcripts (PubMed:10545124, PubMed:10617208, PubMed:12769862, PubMed:14532129, PubMed:16122421, PubMed:25209665, PubMed:9144292, PubMed:9182767). Sxl first acts at the splicing level by promoting retention of an intron in the 5' UTR of msl-2 pre-mRNA (PubMed:10617208). The retained intron contains Sxl-binding sites that are required for subsequent steps of repression: after msl-2 mRNA export into the cytoplasm, Sxl coordinates its translational repression by targeting early steps of translation initiation (PubMed:10545124, PubMed:12769862, PubMed:14532129, PubMed:16122421, PubMed:16452508, PubMed:16452509, PubMed:19941818, PubMed:9144292, PubMed:9182767). Together with how, Sxl also prevents production of msl-2 protein by preventing nuclear export of msl-2 transcripts (PubMed:23788626)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V434;A4V435;A4V436;A4V437;C9QP40;D0IQK2;D3PFI6;E1JJI8;E1JJI9;E1JJJ0;E1JJJ2;E1JJJ3;P19340;Q0KHV2;Q26466;Q2MGN7;Q2MGN8;Q2MGN9;Q2MGP1;Q7KVU6;Q7YZ92;Q8IRQ1;Q99141;Q9TYF5;Q9W3S6", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0007530 sex determination;GO:0046832 negative regulation of RNA export from nucleus;GO:0045880 positive regulation of smoothened signaling pathway;GO:0009994 oocyte differentiation;GO:0033120 positive regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P19339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95RC0-1", "uniprot_id": "NA30A_DROME", "mass": 42250.0, "length": 377, "protein_name": "N-alpha-acetyltransferase 30A", "gene_name": "Naa30A", "organism": "Fruit fly", "refseq_name": "N(alpha)-acetyltransferase 30 A, isoform A", "refseq_ac": "NP_726727", "gene_names_uniprotkb": "Naa30A; CG11412; DmAAF45606; Dmel\\CG11412; Dmel_CG11412; EG:8D8.6; NAA30; Naa30; cg11412", "gene_names_refseq": "CG11412; DmAAF45606; Dmel\\CG11412; EG:8D8.6; NAA30; Naa30A; Naa30; cg11412", "protein_names_uniprotkb": "N-alpha-acetyltransferase 30A; 2.3.1.256; N-acetyltransferase MAK3 homolog; NatC catalytic subunit", "protein_names_refseq": "CG11412-PA; N(alpha)-acetyltransferase 30 A, isoform A; N(alpha)-acetyltransferase 30; Naa30A-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11412)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;37891180", "class_list": "", "function": "Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46309;Q9W5A3", "ec_number_list": "2.3.1.256;2.3.1.258;2.3.1.-", "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031417 NatC complex", "go_biological_process": "GO:1904663 regulation of N-terminal peptidyl-methionine acetylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q95RC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24040-1", "uniprot_id": "BGB_DROME", "mass": 25177.0, "length": 213, "protein_name": "Protein big brother", "gene_name": "Bgb", "organism": "Fruit fly", "refseq_name": "Big brother, isoform A", "refseq_ac": "NP_477065", "gene_names_uniprotkb": "Bgb; 9; CG7959; Dmel\\CG7959; Dmel_CG7959; bgb; rpbeta2", "gene_names_refseq": "Bgb; CG7959; Dmel\\CG7959; bgb; en(lz)D/9; rpbeta2", "protein_names_uniprotkb": "Protein big brother", "protein_names_refseq": "Bgb-PA; Big brother, isoform A; Big brother; Big-brother; CG7959-PA; runt domain partner beta2", "tax_id": 7227, "disease": "acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); cleidocranial dysplasia (Disease Ontology:DOID:13994); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG7959); (R-DME-8877330); (R-DME-8878166); (R-DME-8931987); (R-DME-8934593); (R-DME-8936459); (R-DME-8939236); (R-DME-8939243); (R-DME-8939245); (R-DME-8939246); (R-DME-8939247); (R-DME-8941326); (R-DME-8941858); (R-DME-8951936); (R-DME-9018519)", "pathway_count": 15, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8622696", "class_list": "", "function": "Regulates the DNA-binding properties of Runt., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95TG4;Q9W0B9", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016513 core-binding factor complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0035206 regulation of hemocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q24040-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27716-1", "uniprot_id": "INX1_DROME", "mass": 42582.0, "length": 362, "protein_name": "Innexin inx1", "gene_name": "ogre", "organism": "Fruit fly", "refseq_name": "optic ganglion reduced, isoform C", "refseq_ac": "NP_001245557", "gene_names_uniprotkb": "ogre; CB8; CG3039; Dm-inx1; Dmel\\CG3039; Dmel_CG3039; FBpp0070995; Inx1; Ogre; cb-8; inx-1; inx1; inx; jnL3; l(1)6Ec; l(1)jnL3; l(1)ogre", "gene_names_refseq": "CB8; CG3039; Dm-inx1; Dmel\\CG3039; FBpp0070995; Inx1; Ogre; cb-8; inx-1; inx1; jnL3; l(1)6Ec; l(1)jnL3; l(1)ogre; ogre", "protein_names_uniprotkb": "Innexin inx1; Innexin-1; Protein ogre; Protein optic ganglion reduced", "protein_names_refseq": "CG3039-PC; contrast-blind-8; innexin 1; innexin-1; ogre-PC; optic ganglia-reduced; optic ganglion reduced, isoform C; optic ganglion reduced", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3039)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;11960713;12537568;12537572;12537573;12537574;15047872;16110336;17569856;17569867;19038051;1963867;25589440;26109356;26109357", "class_list": "", "function": "Structural component of the gap junctions., [UniProtKB, UniProtKB]; Structural component of the gap junctions. Essential for generation and/or maintenance of postembryonic neuroblasts and normal development of optic lobe., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KHV4;Q9W3T8", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005921 gap junction", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0007603 phototransduction, visible light;GO:0007602 phototransduction;GO:0007632 visual behavior;GO:0010496 intercellular transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P27716-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24256-1", "uniprot_id": "BARH2_DROME", "mass": 69951.0, "length": 645, "protein_name": "Homeobox protein B-H2", "gene_name": "B-H2", "organism": "Fruit fly", "refseq_name": "BarH2, isoform A", "refseq_ac": "NP_523386", "gene_names_uniprotkb": "B-H2; BH2; Bar-H2; BarH2; BarH; Barh2; Bar; B; CG5488; Dmel\\CG5488; Dmel_CG5488; bar-h2", "gene_names_refseq": "B-H2; BH2; Bar-H2; BarH; Barh2; Bar; B; CG5488; Dmel\\CG5488; bar-h2", "protein_names_uniprotkb": "Homeobox protein B-H2; Homeobox protein BarH2", "protein_names_refseq": "B-H2-PA; BarH2, isoform A; Bar; CG5488-PA", "tax_id": 7227, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); high grade glioma (Disease Ontology:DOID:3070); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG5488)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10068639;10648235;10731132;12537568;12537572;12537573;12537574;1346120;1350558;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24257;Q4V712;Q9VX55", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0008052 sensory organ boundary specification;GO:0008057 eye pigment granule organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q24256-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40427-1", "uniprot_id": "EXD_DROME", "mass": 41692.0, "length": 376, "protein_name": "Homeobox protein extradenticle", "gene_name": "exd", "organism": "Fruit fly", "refseq_name": "extradenticle, isoform D", "refseq_ac": "NP_001259592", "gene_names_uniprotkb": "exd; CG8933; DExd; Dm-EXD; Dmel\\CG8933; Dmel_CG8933; Dpbx; EXD; Exd; Pbx1; anon-EST:fe1H3; l(1)IV; lincRNA.S9404; td48", "gene_names_refseq": "CG8933; DExd; Dm-EXD; Dmel\\CG8933; Dpbx; EXD; Exd; Pbx1; anon-EST:fe1H3; exd; l(1)IV; lincRNA.S9404; td48", "protein_names_uniprotkb": "Homeobox protein extradenticle; Dpbx", "protein_names_refseq": "CG8933-PD; Pbx1-oncogene-like; anon-fast-evolving-1H3; exd-PD; extradenticle, isoform D; extradenticle", "tax_id": 7227, "disease": "congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay (Disease Ontology:DOID:0112359); glaucoma (Disease Ontology:DOID:1686); brain infarction (Disease Ontology:DOID:3454); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dme:Dmel_CG8933)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10067897;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7914871;8100142;8104703;9346235;9450936;9463350", "class_list": "", "function": "Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4K5;Q0KHS1;Q9V3S2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007525 somatic muscle development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40427-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KVY7-1", "uniprot_id": "STX4_DROME", "mass": 38474.0, "length": 333, "protein_name": "Syntaxin-4", "gene_name": "Syx4", "organism": "Fruit fly", "refseq_name": "syntaxin 4, isoform A", "refseq_ac": "NP_525057", "gene_names_uniprotkb": "Syx4; CG2715; Dm Syx4; DmSyx4; Dmel\\CG2715; Dmel_CG2715; EG:95B7.11; EG:95B7.1; STX4; Syx-4; Syx; syx4", "gene_names_refseq": "CG2715; Dm Syx4; DmSyx4; Dmel\\CG2715; EG:95B7.11; EG:95B7.1; STX4; Syx-4; Syx4; Syx; syx4", "protein_names_uniprotkb": "Syntaxin-4", "protein_names_refseq": "CG2715-PA; Syx4-PA; syntaxin 4, isoform A; syntaxin 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2715); (R-DME-114516); (R-DME-199992); (R-DME-449836)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;10731137;12351680;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Potentially involved in docking of synaptic vesicles at presynaptic active zones., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O76905;Q8MM89;Q8MM91;Q8MM96;Q8MTN2;Q8MTN5;Q8SZE9", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0012505 endomembrane system;GO:0098793 presynapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0061025 membrane fusion;GO:0006887 exocytosis;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7KVY7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O96863-1", "uniprot_id": "CSK2C_DROME", "mass": 24966.0, "length": 219, "protein_name": "Casein kinase II subunit beta'", "gene_name": "CkIIbeta2", "organism": "Fruit fly", "refseq_name": "casein kinase II beta2 subunit", "refseq_ac": "NP_477407", "gene_names_uniprotkb": "CkIIbeta2; CG8914", "gene_names_refseq": "CG8914; CK2beta'; CK2; CKIIb2; CKIIbeta'; CKIIbeta2; CkIIbeta2; Dm-CK2-beta'; DmCK2beta'; DmCKIIbeta'; Dmel\\CG8914; dCK2beta'", "protein_names_uniprotkb": "Casein kinase II subunit beta'; CK II beta'; DmCKII-beta'", "protein_names_refseq": "CG8914-PA; CkIIbeta2-PA; casein kinase II beta2 subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8914)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10329473;10731132;12537572", "class_list": "", "function": "Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53XE8;Q9V919", "ec_number_list": "", "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O96863-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O97069-1", "uniprot_id": "ASSY_DROME", "mass": 46595.0, "length": 419, "protein_name": "Argininosuccinate synthase", "gene_name": "Ass", "organism": "Fruit fly", "refseq_name": "argininosuccinate synthase, isoform B", "refseq_ac": "NP_001262324", "gene_names_uniprotkb": "Ass; CG1315", "gene_names_refseq": "Ass; BG:DS00004.14; CG1315; Dmel\\CG1315", "protein_names_uniprotkb": "Argininosuccinate synthase; 6.3.4.5; Citrulline--aspartate ligase", "protein_names_refseq": "Ass-PB; CG1315-PB; argininosuccinate synthase, isoform B; argininosuccinate synthase-like; argininosuccinate synthase", "tax_id": 7227, "disease": "classic citrullinemia (Disease Ontology:DOID:0070340); Alzheimer's disease (Disease Ontology:DOID:10652); uveitis (Disease Ontology:DOID:13141); melanoma (Disease Ontology:DOID:1909); hepatocellular carcinoma (Disease Ontology:DOID:684); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (dme:Dmel_CG1315)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KFC7;C0HDN4;Q9VI41", "ec_number_list": "6.3.4.5", "go_molecular_function": "GO:0005524 ATP binding;GO:0004055 argininosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000050 urea cycle;GO:0000053 argininosuccinate metabolic process;GO:0006526 L-arginine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O97069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00417-1", "uniprot_id": "COX3_DROME", "mass": 30064.0, "length": 262, "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "mt:CoIII", "organism": "Fruit fly", "refseq_name": "cytochrome c oxidase subunit III", "refseq_ac": "YP_009047271", "gene_names_uniprotkb": "mt:CoIII; CoIII", "gene_names_refseq": "COX3; mt:CoIII", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 3; 7.1.1.9; Cytochrome c oxidase polypeptide III", "protein_names_refseq": "cytochrome c oxidase subunit III", "tax_id": 7227, "disease": "MELAS syndrome (Disease Ontology:DOID:3687)", "pathway": " (dme:Dmel_CG34074); (R-DME-5419276); (R-DME-5628897); (R-DME-611105); (R-DME-9707564); (R-DME-9864848)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10903372;11298822;18296276;3130291;6304652;6408489;8825764", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1PTQ2;Q7HMA0;Q9MGN4", "ec_number_list": "7.1.1.9;7.1.1.2;3.1.1.29", "go_molecular_function": "GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P00417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00850-1", "uniprot_id": "ATP6_DROME", "mass": 25161.0, "length": 224, "protein_name": "ATP synthase subunit a", "gene_name": "mt:ATPase6", "organism": "Fruit fly", "refseq_name": "ATP synthase F0 subunit 6", "refseq_ac": "YP_009047270", "gene_names_uniprotkb": "mt:ATPase6; ATP6; ATPase6", "gene_names_refseq": "ATP6; mt:ATPase6", "protein_names_uniprotkb": "ATP synthase subunit a; F-ATPase protein 6", "protein_names_refseq": "ATP synthase F0 subunit 6", "tax_id": 7227, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); NARP syndrome (Disease Ontology:DOID:0111273); Leber hereditary optic neuropathy and dystonia (Disease Ontology:DOID:0111755); prostate cancer (Disease Ontology:DOID:10283); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Parkinson's disease (Disease Ontology:DOID:14330); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); parathyroid carcinoma (Disease Ontology:DOID:1540); breast cancer (Disease Ontology:DOID:1612); thyroid cancer (Disease Ontology:DOID:1781); multiple sclerosis (Disease Ontology:DOID:2377); Leigh disease (Disease Ontology:DOID:3652); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557); mitochondrial metabolism disease (Disease Ontology:DOID:700); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dme:Dmel_CG34073); (R-DME-163210); (R-DME-5419276); (R-DME-8949613); (R-DME-9837999)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "11298822;18296276;6408489;8825764", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2L9S2;Q9MGN5;Q9MGP0;Q9MJC8", "ec_number_list": "", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0046716 muscle cell cellular homeostasis;GO:0070050 neuron cellular homeostasis;GO:0015986 proton motive force-driven ATP synthesis;GO:0040011 locomotion;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P00850-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00967-1", "uniprot_id": "PUR2_DROME", "mass": 144525.0, "length": 1353, "protein_name": "Trifunctional purine biosynthetic protein adenosine-3", "gene_name": "Gart", "organism": "Fruit fly", "refseq_name": "GART trifunctional enzyme, isoform B", "refseq_ac": "NP_001014477", "gene_names_uniprotkb": "Gart; CG31628; ade3", "gene_names_refseq": "143062_at; ADE8; Ade3; CG31628; CG8761; Dmel\\CG31628; D; GART; Gart/ade3; Gart; ade3; gart; l(2)27Da", "protein_names_uniprotkb": "Trifunctional purine biosynthetic protein adenosine-3; 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; Glycinamide ribonucleotide synthetase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide synthetase", "protein_names_refseq": "CG31628-PB; GART trifunctional enzyme, isoform B; Gart-PB; adenosine 3; complementation group D", "tax_id": 7227, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (dme:Dmel_CG31628); (R-DME-73817)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537572;18327897;3086869;3123310;6300768;6413075", "class_list": "", "function": "Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q59DZ6;Q9VM53;X2J516", "ec_number_list": "2.1.2.2;6.3.3.1;6.3.4.13", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004637 phosphoribosylamine-glycine ligase activity;GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity;GO:0004644 phosphoribosylglycinamide formyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009113 purine nucleobase biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0046084 adenine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P00967-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02572-1", "uniprot_id": "ACT2_DROME", "mass": 41824.0, "length": 376, "protein_name": "Actin-42A", "gene_name": "Act42A", "organism": "Fruit fly", "refseq_name": "actin 42A", "refseq_ac": "NP_523625", "gene_names_uniprotkb": "Act42A; CG12051", "gene_names_refseq": "42A; ACT2_DROME; ACT2; ACT42A; AFFX-Dros-ACTIN_M_r_at; Act42A; Act42a; Act42; Actin/BAP47; Actin; Act; ArpB; A; BAP47; CG12051; C; Dmel\\CG12051; act 42A; act42A; actin-42A; actin", "protein_names_uniprotkb": "Actin-42A; 3.6.4.-", "protein_names_refseq": "42A actin; Act42A-PA; Actin-42A; CG12051-PA; F-actin; actin 42A; actin42a", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Baraitser-Winter syndrome 2 (Disease Ontology:DOID:0081113); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); hand, foot and mouth disease (Disease Ontology:DOID:10881); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); thrombocytopenia (Disease Ontology:DOID:1588); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dme:Dmel_CG12051); (R-DME-114608); (R-DME-9035034)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;1694472;22116028;2436146;30526847;6263481;9344535", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24228;Q540X3;Q9V9J4", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.5.2;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;1.15.1.1;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.1.3.95;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0035060 brahma complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0000281 mitotic cytokinesis;GO:0030723 ovarian fusome organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P02572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04412-1", "uniprot_id": "EGFR_DROME", "mass": 159718.0, "length": 1426, "protein_name": "Epidermal growth factor receptor", "gene_name": "Egfr", "organism": "Fruit fly", "refseq_name": "epidermal growth factor receptor, isoform B", "refseq_ac": "NP_476759", "gene_names_uniprotkb": "Egfr; C-erb; CG10079; D-EGFR; D-Egf; DEGFR; DER flb; DER1; DER; DEgfr; Degfr; Der; DmHD-33; Dmel\\CG10079; Dmel_CG10079; EC2-4; EFG-R; EGF-R; EGFR; EGFr; EGF; EGfr; EK2-6; EgFr; Egf-r; EgfR; Egfr; Egf; Elp-1; Elp-B1RB1; Elp-B1; Elp; El; HD-33; TOP; Top; Torpedo; c-erbB; d-egf-r; dEGFR1; dEGFR; dEGFr; dEgfr; degfr; der; egfr; flb; l(2)05351; l(2)09261; l(2)57DEFa; l(2)57EFa; l(2)57Ea; mor1; top; torpedo", "gene_names_refseq": "C-erb; CG10079; D-EGFR; D-Egf; DEGFR; DER flb; DER/EGFR; DER/top; DER/torpedo; DER1; DER; DEgfr; Degfr; Der; DmHD-33; Dmel\\CG10079; EC2-4; EFG-R; EGF-R; EGFR; EGFr; EGF; EGfr; EK2-6; EgFr; Egf-r; EgfR; Egfr; Egf; Elp-1; Elp-B1RB1; Elp-B1; Elp; El; HD-33; TOP; Top; Torpedo/DER; Torpedo/Egfr; Torpedo; c-erbB; d-egf-r; dEGFR1; dEGFR; dEGFr; dEgfr; degfr; der; egfr; flb; l(2)05351; l(2)09261; l(2)57DEFa; l(2)57EFa; l(2)57Ea; mor1; top/DER; top/flb; top; torpedo/Egfr; torpedo/egfr", "protein_names_uniprotkb": "Epidermal growth factor receptor; 2.7.10.1; Drosophila relative of ERBB; Egfr; Gurken receptor; Protein torpedo", "protein_names_refseq": "CG10079-PB; DER-Ellipse; EGF-receptor; EGFR; Egf receptor; Egfr-PB; dEGFR; drosophila epidermal growth factor receptor homologue; ellipse torpedo; epidermal growth factor receptor, isoform B; epidermal growth factor receptor; faint little ball; morphological defects 1; torpedo/DER", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); nicotine dependence (Disease Ontology:DOID:0050742); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 19 (Disease Ontology:DOID:0060210); lethal congenital contracture syndrome 2 (Disease Ontology:DOID:0060560); neonatal nephrocutaneous inflammatory syndrome (Disease Ontology:DOID:0061191); Coronavirus infectious disease (Disease Ontology:DOID:0080599); neuronal intestinal dysplasia type A (Disease Ontology:DOID:0080679); Parkinsonism (Disease Ontology:DOID:0080855); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); dilated cardiomyopathy (Disease Ontology:DOID:12930); dementia (Disease Ontology:DOID:1307); HELLP syndrome (Disease Ontology:DOID:13133); lung cancer (Disease Ontology:DOID:1324); interstitial cystitis (Disease Ontology:DOID:13949); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); calcinosis (Disease Ontology:DOID:182); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); mammary Paget's disease (Disease Ontology:DOID:3443); invasive lobular carcinoma (Disease Ontology:DOID:3457); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); radiculopathy (Disease Ontology:DOID:4306); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); aortic valve disease (Disease Ontology:DOID:62); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG10079); (R-DME-1227986); (R-DME-1236394); (R-DME-1250196); (R-DME-1250342); (R-DME-1250347); (R-DME-1251985); (R-DME-1253288); (R-DME-1257604); (R-DME-1358803); (R-DME-177929); (R-DME-179812); (R-DME-180292); (R-DME-180336); (R-DME-182971); (R-DME-1963640); (R-DME-1963642); (R-DME-212718); (R-DME-2179392); (R-DME-416572); (R-DME-445144); (R-DME-5673001); (R-DME-6785631); (R-DME-6811558); (R-DME-8856825); (R-DME-8856828); (R-DME-8863795); (R-DME-9018519); (R-DME-9652282)", "pathway_count": 29, "publication_count": 29, "publication_id_list": "10731132;10781813;12537568;12537572;12537573;12537574;15952742;16110336;17569856;17569867;1936959;19718021;20723758;22140578;23029159;23579691;24855950;25589440;26109356;26109357;28993397;2982499;2983232;3093080;34411095;8070664;9094709;9731193;9882502", "class_list": "", "function": "Receptor tyrosine kinase, binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:22140578, PubMed:23579691, PubMed:8070664, PubMed:9882502). Known ligands include spitz, gurken, vein and giant-lens (PubMed:19718021, PubMed:20723758, PubMed:22140578, PubMed:9882502). Transduces the signal through the ras-raf-MAPK pathway (PubMed:9094709). Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte (PubMed:23579691, PubMed:34411095, PubMed:9882502). In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system, and production and repair of the cuticle (PubMed:22140578, PubMed:23029159, PubMed:23579691, PubMed:9094709). During dorsal closure (DC) functions with the dpp- and ACK-signaling pathways to regulate expression of the myosin zip in the embryonic epidermis and amnioserosa (AS), and thus coordinate the progression of epidermal cell shape changes required for correct DC (PubMed:23579691). In the embryonic epidermis, functions by negatively regulating dpp and consequently the dpp-dependent expression of the myosin zip (PubMed:23579691). In the AS, negatively regulates the production/ and or secretion of a diffusible signal which, is produced by the ACK-signaling pathway, and acts in the AS and epidermal cells to promote zip expression (PubMed:23579691). Also required in the AS to inhibit or delay apoptosis, and consequently slow the rate of DC (PubMed:23579691). Therefore functions at multiple levels to negatively regulate morphogenesis during DC, suggesting that it acts as a general brake mechanism for adjusting the rate of dorsal closure to ensure that closure proceeds smoothly and without loss of epidermal integrity (PubMed:23579691). During oogenesis, one of two tyrosine kinase chemoattractant receptors (Egfr and Pvr), that function in the border cells (BC) to detect guidance cues from the oocyte and transduce this information to the guidance pathway that regulate the collective migration of the BC cluster through the nurse cells to the oocyte (PubMed:24855950)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 31, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 74, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "O18370;O61601;P81868;Q9W2G0", "ec_number_list": "3.1.3.-;3.1.3.48;2.7.10.1;3.4.23.-;3.1.3.56;2.7.10.2;3.6.5.2;3.6.4.-;3.6.5.5;2.7.12.1;2.7.12.2;1.1.1.-;2.7.11.22;2.3.2.27;3.2.1.21;3.2.1.46;2.3.2.26;3.1.4.11;2.7.11.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005006 epidermal growth factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0048749 compound eye development;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P04412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04814-1", "uniprot_id": "TRYA_DROME", "mass": 26041.0, "length": 256, "protein_name": "Trypsin alpha", "gene_name": "alphaTry", "organism": "Fruit fly", "refseq_name": "alphaTrypsin", "refseq_ac": "NP_476771", "gene_names_uniprotkb": "alphaTry; CG18444; TRY-ALPHA", "gene_names_refseq": "AlphaTry; CG18444; DmAlphaTry; Dmel\\CG18444; SP102; Try; alpha-Try; alphaTry; alpha", "protein_names_uniprotkb": "Trypsin alpha; 3.4.21.4", "protein_names_refseq": "CG18444-PA; alphaTry-PA; alphaTrypsin", "tax_id": 7227, "disease": "amelogenesis imperfecta type 2A1 (Disease Ontology:DOID:0110057); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG18444)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10486967;10731132;12537572;2414727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q541G0;Q9V5Y2", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04814-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05623-1", "uniprot_id": "A70A_DROME", "mass": 6362.0, "length": 55, "protein_name": "Sex peptide", "gene_name": "SP", "organism": "Fruit fly", "refseq_name": "Sex peptide", "refseq_ac": "NP_524057", "gene_names_uniprotkb": "SP; Acp70A; CG17673; PAPB", "gene_names_refseq": "ACP70A; ACP; Acp-70A; Acp70A; Acp70a; Acp70; Apc70A; CG17673; DmSP; Dmel\\CG17673; DrmSP; PapB; SP; Spg70; Sp; mSP; sex peptide; sp", "protein_names_uniprotkb": "Sex peptide; Accessory gland-specific peptide 70A; Paragonial peptide B", "protein_names_refseq": "CG17673-PA; DrmSP; Paragonial-peptide-B; SP-PA; Sex peptide; Sex-Peptide; accessory gland peptide 70A; accessory gland protein 70A; accessory protein 70A; sex peptide gene in 70; sexpeptide", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17673)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537572;12897240;14761057;15694303;19249273;19793753;20308537;20458515;21439282;24089336;3135120;33495334;9286679", "class_list": "", "function": "Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila (PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:20308537, PubMed:24089336, PubMed:3135120). Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors (PubMed:20308537, PubMed:20458515, PubMed:24089336). Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial peptide synthesis, reduced mating receptivity, reduced day-time sleep and reduced lifespan in multiple mated females (PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:24089336, PubMed:3135120). Structural component of large neutral lipid-containing microcarriers produced by male accessory gland main cells; involved in their morphogenesis and their role in delivering lipids and lipid associated proteins to females during mating (PubMed:33495334)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18659;Q4V3K7;Q6VBF8;Q9VU54", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007621 negative regulation of female receptivity;GO:0007320 insemination;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008343 adult feeding behavior;GO:0046008 regulation of female receptivity, post-mating", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P05623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05990-1", "uniprot_id": "PYR1_DROME", "mass": 246672.0, "length": 2224, "protein_name": "Multifunctional protein r", "gene_name": "r", "organism": "Fruit fly", "refseq_name": "rudimentary, isoform D", "refseq_ac": "NP_001285343", "gene_names_uniprotkb": "r; ACT; CAD; CG18572; CG4601; CPS; DHO; DRORUD; Dmel\\CG18572; Dmel_CG18572; GAT; PYR1; R; Su(b); csp2; fs(1)829; fs(1)M34; l(1)Ab", "gene_names_refseq": "ACT; CAD; CG18572; CG4601; CPS; DHO; DRORUD; Dmel\\CG18572; GAT; PYR1; R; Su(b); csp2; fs(1)829; fs(1)M34; l(1)Ab; r", "protein_names_uniprotkb": "Multifunctional protein r; Protein rudimentary", "protein_names_refseq": "CG18572-PD; Suppressor-of-black; carbamoylphosphate synthetase; r-PD; rudimentary gene; rudimentary, isoform D; suppressor of black", "tax_id": 7227, "disease": "orotic aciduria (Disease Ontology:DOID:0050833); developmental and epileptic encephalopathy 50 (Disease Ontology:DOID:0080419); rhabdomyosarcoma (Disease Ontology:DOID:3247); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); carbamoyl phosphate synthetase I deficiency disease (Disease Ontology:DOID:9280)", "pathway": " (dme:Dmel_CG18572); (R-DME-500753)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10080891;10731132;12537568;12537569;12537572;12537573;12537574;1329025;16110336;17569856;17569867;18327897;25589440;26109356;26109357;2884325;3023623;7932764", "class_list": "", "function": "Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5X540;O97163;Q26376;Q7KUX4;Q8SXM0;Q9VXD5", "ec_number_list": "6.3.4.16;2.1.3.2;3.5.2.3;6.3.5.5;3.5.1.2;3.-.-.-;3.5.-.-;2.1.3.-;3.5.2.-", "go_molecular_function": "GO:0004087 carbamoyl-phosphate synthase (ammonia) activity;GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004151 dihydroorotase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0006541 glutamine metabolic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P05990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06002-1", "uniprot_id": "OPS1_DROME", "mass": 41495.0, "length": 373, "protein_name": "Opsin Rh1", "gene_name": "ninaE", "organism": "Fruit fly", "refseq_name": "neither inactivation nor afterpotential E", "refseq_ac": "NP_524407", "gene_names_uniprotkb": "ninaE; CG4550; Rh1", "gene_names_refseq": "143283_at; 1F9; BEST:GH11778; CG4550; DMELRH1; DRh1; Dm Rh1; DmRh1; Dmel\\CG4550; Nina E; NinaE; RH1; Rh-1; Rh1(ninaE); Rh1/ninaE; Rh1; Rhodopsin-1; Rh; R; ninaE; opsin; ora; r1; rh1/ninaE; rh1; rhodopsin", "protein_names_uniprotkb": "Opsin Rh1; Neither inactivation nor afterpotential E protein; Outer R1-R6 photoreceptor cells opsin", "protein_names_refseq": "CG4550-PA; neither inactivation nor afterpotential E; ninaE-PA; rhodopsin 1; rhodopsin-1; rhodopsin1; rhodopsin", "tax_id": 7227, "disease": "retinitis pigmentosa 4 (Disease Ontology:DOID:0110372); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG4550)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;10811808;12537572;1534022;17893096;23226104;2580638;2985266;33925313;8006992;9130705", "class_list": "", "function": "Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0AVV9;Q4QPQ2;Q9TX56;Q9VDS8", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0016028 rhabdomere;GO:0016027 inaD signaling complex", "go_biological_process": "GO:0009584 detection of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008344 adult locomotory behavior;GO:0007601 visual perception;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P06002-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06601-1", "uniprot_id": "PRD_DROME", "mass": 65497.0, "length": 613, "protein_name": "Segmentation protein paired", "gene_name": "prd", "organism": "Fruit fly", "refseq_name": "paired, isoform A", "refseq_ac": "NP_523556", "gene_names_uniprotkb": "prd; CG6716", "gene_names_refseq": "CG6716; Dmel\\CG6716; PRD; Prd; prd; pr", "protein_names_uniprotkb": "Segmentation protein paired", "protein_names_refseq": "CG6716-PA; paired, isoform A; paired; prd-PA", "tax_id": 7227, "disease": "neural tube defect (Disease Ontology:DOID:0080074); congenital myopathy 19 (Disease Ontology:DOID:0081351); Waardenburg syndrome type 1 (Disease Ontology:DOID:0110948); Waardenburg syndrome type 3 (Disease Ontology:DOID:0110949); craniofacial-deafness-hand syndrome (Disease Ontology:DOID:0111336); prostate cancer (Disease Ontology:DOID:10283); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (dme:Dmel_CG6716); (R-DME-3214847)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;2877746;7671301;7867071", "class_list": "", "function": "Pair-rule protein expressed in a segmentally repeating pattern to define the polarity of embryonic segments. Capable of sequence-specific DNA-binding., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VKB6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P06601-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06602-1", "uniprot_id": "EVE_DROME", "mass": 39970.0, "length": 376, "protein_name": "Segmentation protein even-skipped", "gene_name": "eve", "organism": "Fruit fly", "refseq_name": "even skipped", "refseq_ac": "NP_523670", "gene_names_uniprotkb": "eve; CG2328", "gene_names_refseq": "10.5; 10.9; 14.10; 20.35; CG2328; Dm-eve; Dmel\\CG2328; E(eve); EVE; Even; Eve; F; VI; V; dm-eve; eve2; even; eve; l(2)46CFg; l(2)46CFh; l(2)46CFj; l(2)46CFp; l(2)46Ce; l(2)46Cg", "protein_names_uniprotkb": "Segmentation protein even-skipped", "protein_names_refseq": "CG2328-PA; complementation group F; eve PRE/TRE element; eve-PA; even skipped; even-skiped; even-skipped; evenskipped; evenskip; group VI; group V; lethal(2)46Ce", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2328)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;2877745;2884106;8524036;8557047", "class_list": "", "function": "May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair-rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07667;Q9V5E6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P06602-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06607-1", "uniprot_id": "VIT3_DROME", "mass": 46101.0, "length": 420, "protein_name": "Vitellogenin-3", "gene_name": "Yp3", "organism": "Fruit fly", "refseq_name": "yolk protein 3, isoform B", "refseq_ac": "NP_001285228", "gene_names_uniprotkb": "Yp3; CG11129; DIM 30; Dmel\\CG11129; Dmel_CG11129; RH08557p; VG3; VIT3Dm; YP-3; YP3; YP[[3]]; YP; fs(1)1526; fs(1)A1526; yp3; yp", "gene_names_refseq": "CG11129; DIM 30; Dmel\\CG11129; RH08557p; VG3; VIT3Dm; YP-3; YP3; YP[[3]]; YP; Yp3; fs(1)1526; fs(1)A1526; yp3; yp", "protein_names_uniprotkb": "Vitellogenin-3; Vitellogenin III; Yolk protein 3", "protein_names_refseq": "CG11129-PB; Yp3-PB; vitellogenin; yolk protein 3, isoform B; yolk protein 3; yolk protein", "tax_id": 7227, "disease": "hypotrichosis 7 (Disease Ontology:DOID:0110704)", "pathway": " (dme:Dmel_CG11129); (R-DME-192456); (R-DME-8963889); (R-DME-8964058)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;1909425;25589440;26109356;26109357;3029679;3114046;33891588;3922974", "class_list": "", "function": "Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. Vitellogenins and their receptor yl/yolkless are required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis by yl/yolkless is crucial for actin reorganization, mediated by osk isoform A/Long, required to anchor germ plasm components to the oocyte cortex (PubMed:33891588)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MYV8;Q9VY89", "ec_number_list": "", "go_molecular_function": "GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043186 P granule", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0016042 lipid catabolic process;GO:0009617 response to bacterium;GO:0007548 sex differentiation;GO:0045995 regulation of embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P06607-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07184-1", "uniprot_id": "CH18_DROME", "mass": 17231.0, "length": 172, "protein_name": "Chorion protein S18", "gene_name": "Cp18", "organism": "Fruit fly", "refseq_name": "chorion protein 18", "refseq_ac": "NP_523978", "gene_names_uniprotkb": "Cp18; CG6517; s18", "gene_names_refseq": "ACE3; CG6517; CP18; Cp18; Dmel\\CG6517; Dms18; E5; S-18; S18; cp18; s-18; s18-1; s18", "protein_names_uniprotkb": "Chorion protein S18", "protein_names_refseq": "CG6517-PA; Cp18-PA; Shell-18; chorion protein 18", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6517)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;17244601;2988878;3924529", "class_list": "", "function": "Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4ULX3;A8E6T8;Q9VSP1", "ec_number_list": "", "go_molecular_function": "GO:0005213 structural constituent of egg chorion", "go_cellular_component": "GO:0005576 extracellular region;GO:0042600 egg chorion", "go_biological_process": "GO:0007304 chorion-containing eggshell formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07190-1", "uniprot_id": "MAL1_DROME", "mass": 66386.0, "length": 577, "protein_name": "Maltase A1", "gene_name": "Mal-A1", "organism": "Fruit fly", "refseq_name": "maltase A1", "refseq_ac": "NP_476627", "gene_names_uniprotkb": "Mal-A1; CG8696; LvpH", "gene_names_refseq": "CG8696; Dmel\\CG8696; Drome_A1; H; LvpH; Mal-A1; V; lvpH; mal_A1", "protein_names_uniprotkb": "Maltase A1; 3.2.1.20; Larval visceral protein H", "protein_names_refseq": "CG8696-PA; Mal-A1-PA; gene V; hdl cuticle gene cluster; larval visceral protein H; maltase A1; maltase H precursor", "tax_id": 7227, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (dme:Dmel_CG8696)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;6854639", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9V4T6", "ec_number_list": "", "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07190-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07192-1", "uniprot_id": "MAL3_DROME", "mass": 65235.0, "length": 574, "protein_name": "Maltase A3", "gene_name": "Mal-A3", "organism": "Fruit fly", "refseq_name": "maltase A3", "refseq_ac": "NP_476628", "gene_names_uniprotkb": "Mal-A3; CG8695; LvpL", "gene_names_refseq": "CG8695; Dmel\\CG8695; Drome_A3; LvpL; L; Mal-A3; V; lvpL; mal_A3", "protein_names_uniprotkb": "Maltase A3; 3.2.1.20; Larval visceral protein L", "protein_names_refseq": "CG8695-PA; Mal-A3-PA; gene V; hdl cuticle gene cluster; larval visceral protein L; maltase A3; maltase", "tax_id": 7227, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (dme:Dmel_CG8695)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;21082169;6854639", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9V4T8", "ec_number_list": "", "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07192-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07247-1", "uniprot_id": "KRUP_DROME", "mass": 54715.0, "length": 502, "protein_name": "Protein krueppel", "gene_name": "Kr", "organism": "Fruit fly", "refseq_name": "kruppel, isoform B", "refseq_ac": "NP_001261181", "gene_names_uniprotkb": "Kr; CG3340", "gene_names_refseq": "CG3340; Dm-Kr; Dmel\\CG3340; If; KR; Kru; Kr; kr", "protein_names_uniprotkb": "Protein krueppel", "protein_names_refseq": "CG3340-PB; Kr-PB; irregular facets; krpple; krueppel; kruppel, isoform B; kruppel; kuppel; lruppel", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3340)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;1438276;18327897;3112773", "class_list": "", "function": "Krueppel is a gap class segmentation protein. It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYW3;Q9W0V9", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0007354 zygotic determination of anterior/posterior axis, embryo;GO:0048749 compound eye development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P07247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07486-1", "uniprot_id": "G3P1_DROME", "mass": 35350.0, "length": 332, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase 1", "gene_name": "Gapdh1", "organism": "Fruit fly", "refseq_name": "glyceraldehyde 3 phosphate dehydrogenase 1, isoform B", "refseq_ac": "NP_001033936", "gene_names_uniprotkb": "Gapdh1; CG12055; Gadph-1", "gene_names_refseq": "BEST:GH12586; CG12055; Dmel\\CG12055; GA3PDH; GADPH; GAPDH I; GAPDH-1; GAPDH1; GAPDHI; GAPDH; GAP; Gadph1; Gapdh-1; Gapdh1; Gapdh43E; Gapdh; Gapd; dmGAPDH; gapdh-1; gapdh1; gapdh; gh12586", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase 1; 1.2.1.12; GAPDH I; Glyceraldehyde-3-phosphate dehydrogenase I", "protein_names_refseq": "CG12055-PB; G3-P dehydrogenase; GAPDH1; Gapdh1-PB; Glyceraldehyde-3-phosphate dehydrogenase1; glyceraldehyde 3 phosphate dehydrogenase 1, isoform B; glyceraldehyde 3 phosphate dehydrogenase1; glyceraldehyde-3-phosphate dehydrogenase", "tax_id": 7227, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); brain glioma (Disease Ontology:DOID:0060108); Alzheimer's disease (Disease Ontology:DOID:10652); epilepsy (Disease Ontology:DOID:1826); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG12055); (R-DME-70171); (R-DME-70263)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15952742;17379620;2989282", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZ75;A5XCT3;A5XCT7;Q8SXG8;Q9V318", "ec_number_list": "1.2.1.12", "go_molecular_function": "GO:0051287 NAD binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0035605 peptidyl-cysteine S-nitrosylase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030018 Z disc;GO:0031430 M band", "go_biological_process": "GO:0019682 glyceraldehyde-3-phosphate metabolic process;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P07486-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07664-1", "uniprot_id": "SRYD_DROME", "mass": 50028.0, "length": 433, "protein_name": "Serendipity locus protein delta", "gene_name": "Sry-delta", "organism": "Fruit fly", "refseq_name": "serendipity delta", "refseq_ac": "NP_524581", "gene_names_uniprotkb": "Sry-delta; CG17958; Sry-d", "gene_names_refseq": "CG17958; Dmel\\CG17958; EH8; Sry delta; Sry-delta; Srydelta; anon-EH8; sry delta; sry-delta; srydelta; sry", "protein_names_uniprotkb": "Serendipity locus protein delta; Serendipity-delta", "protein_names_refseq": "CG17958-PA; Sry-delta-PA; serendipity delta; serendipity-delta", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17958)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;1849091;1868833;2081456;35580610;3935797;6329730;9154812;9858707", "class_list": "", "function": "Transcriptional activator that controls bicoid gene expression during oogenesis. Found in transcriptionally active cells. Binds to specific sites on polytene chromosomes of third instar larvae. Binds to the consensus DNA sequence 5'-YTAGAGATGGRAA-3'., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VAB3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005705 polytene chromosome interband", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048477 oogenesis;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P07664-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08099-1", "uniprot_id": "OPS2_DROME", "mass": 42722.0, "length": 381, "protein_name": "Opsin Rh2", "gene_name": "Rh2", "organism": "Fruit fly", "refseq_name": "rhodopsin 2", "refseq_ac": "NP_524398", "gene_names_uniprotkb": "Rh2; CG16740", "gene_names_refseq": "CG16740; DMELRH2; Dm Rh2; Dmel\\CG16740; RH2; Rh2; Rh; r2; rh2", "protein_names_uniprotkb": "Opsin Rh2; Ocellar opsin", "protein_names_refseq": "CG16740-PA; Rh2-PA; rhodopsin 2; rhodopsin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16740)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;2455230;2936466;2968518", "class_list": "", "function": "Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VE29", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P08099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09090-1", "uniprot_id": "ZEN2_DROME", "mass": 29027.0, "length": 252, "protein_name": "Protein zerknuellt 2", "gene_name": "zen2", "organism": "Fruit fly", "refseq_name": "zerknullt-related, isoform A", "refseq_ac": "NP_476794", "gene_names_uniprotkb": "zen2; CG1048; z2", "gene_names_refseq": "BG:DS00276.10; CG1048; Dmel\\CG1048; z2; zen2; zpr", "protein_names_uniprotkb": "Protein zerknuellt 2; ZEN-2", "protein_names_refseq": "CG1048-PA; Zerknullt-related; zen-pattern-related; zen2-PA; zerknullt 2; zerknullt-related, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1048)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;2892759", "class_list": "", "function": "Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V3K6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09090-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09208-1", "uniprot_id": "INSR_DROME", "mass": 239776.0, "length": 2144, "protein_name": "Insulin-like receptor", "gene_name": "InR", "organism": "Fruit fly", "refseq_name": "Insulin-like receptor, isoform B", "refseq_ac": "NP_001138093", "gene_names_uniprotkb": "InR; CG18402; Dir-a; IR; Inr-a", "gene_names_refseq": "18402; CG18402; DIHR; DILR; DIRH; DIRbeta; DIR; DInR; DInr; Dir-a; Dir-b; Dmel\\CG18402; INR; INS; IR; Igfr1; InR; Inr-alpha; Inr-beta; Inr; InsR; RTK; dINR; dINSR; dIRH; dIR; dInR; dInr; dInsR; dinR; dinr; dir; er10; inR; inr; insulin/insulin-like growth factor receptor; l(3)05545; l(3)93Dj; l(3)er10; lnR; sprout", "protein_names_uniprotkb": "Insulin-like receptor; 2.7.10.1; Insulin receptor homolog; Insulin-like receptor free C-terminus; Insulin-like receptor subunit beta 170 kDa form; Insulin-like receptor subunit beta 90 kDa form; Receptor protein-tyrosine kinase InR; beta170; beta90; dIRH; dIR; dInr; dmIR", "protein_names_refseq": "CG18402-PB; Igf-1 receptor; InR-PB; Insulin-like receptor, isoform B; Insulin-receptor; drosophila insulin receptor; insulin receptor homologue; insulin receptor homolog; insulin-like receptor tyrosine kinase; insulin-like receptor; insulin/IGF receptor; lethal(3)93Dj; sprout", "tax_id": 7227, "disease": "Donohue syndrome (Disease Ontology:DOID:0050470); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); cardiomyopathy (Disease Ontology:DOID:0050700); alcohol dependence (Disease Ontology:DOID:0050741); Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); familial hyperinsulinemic hypoglycemia 5 (Disease Ontology:DOID:0070220); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); short bowel syndrome (Disease Ontology:DOID:10605); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); gastroschisis (Disease Ontology:DOID:11044); prostatic hypertrophy (Disease Ontology:DOID:11132); cryptorchidism (Disease Ontology:DOID:11383); osteoporosis (Disease Ontology:DOID:11476); portal vein thrombosis (Disease Ontology:DOID:11695); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Lewy body dementia (Disease Ontology:DOID:12217); Graves' disease (Disease Ontology:DOID:12361); dementia (Disease Ontology:DOID:1307); hepatic encephalopathy (Disease Ontology:DOID:13413); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); nephroblastoma (Disease Ontology:DOID:2154); prostate adenocarcinoma (Disease Ontology:DOID:2526); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); choriocarcinoma (Disease Ontology:DOID:3594); toxic encephalopathy (Disease Ontology:DOID:3602); glucose metabolism disease (Disease Ontology:DOID:4194); coronary stenosis (Disease Ontology:DOID:4248); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); liver cirrhosis (Disease Ontology:DOID:5082); sleep disorder (Disease Ontology:DOID:535); gastrinoma (Disease Ontology:DOID:5577); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); vesicoureteral reflux (Disease Ontology:DOID:9620); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG18402); (R-DME-110478); (R-DME-77387); (R-DME-9009391)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10455177;10731132;10801879;11250149;11292875;11752451;11872800;12537572;12702880;12893776;18327897;19349973;21707536;22645656;2454394;3014506;3099787;37636057;37805602;7628438;7876183;8603594;8978685;9169420;9368760", "class_list": "", "function": "Has a ligand-stimulated tyrosine-protein kinase activity (PubMed:7628438, PubMed:8603594). Binds 3 insulin-like peptide ligands (PubMed:37805602). Regulates cell number and cell size during development by regulating cell growth and survival, affecting body size and organ size, including ovaries and imaginal disks (PubMed:10455177, PubMed:11250149, PubMed:8603594). Plays a role in life-span determination (PubMed:11292875). May be involved in regulation of other neuroendocrine signaling pathways (PubMed:11292875). Involved in the development of the embryonic nervous system (PubMed:7628438). Functions upstream of dock/dreadlocks for photoreceptor (R cell) axon guidance and targeting in the visual system (PubMed:12702880). Involved in the acs mediated recovery of gut enterocytes following the cytoplasmic purge response to intestinal bacterial infection (PubMed:37636057)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 13, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 13, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 13, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 63, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0N6;Q24023;Q24089;Q9VD94", "ec_number_list": "2.7.10.1;2.7.10.2;3.1.3.48;2.7.12.1;2.7.12.2;2.7.11.22;2.7.11.1", "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005886 plasma membrane;GO:0030424 axon;GO:0005899 insulin receptor complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0042321 negative regulation of circadian sleep/wake cycle, sleep;GO:0009792 embryo development ending in birth or egg hatching;GO:0060180 female mating behavior;GO:0033500 carbohydrate homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P09208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09615-1", "uniprot_id": "WNTG_DROME", "mass": 51986.0, "length": 468, "protein_name": "Protein wingless", "gene_name": "wg", "organism": "Fruit fly", "refseq_name": "wingless", "refseq_ac": "NP_523502", "gene_names_uniprotkb": "wg; CG4889", "gene_names_refseq": "Br; CG4889; D.int-1; DWint-1; DWnt-1; Dint-1; Dm Wg; Dm-1; Dmel\\CG4889; Dwnt-1; Gla; I; Sp; WG; WNT; Wg; Wnt-1; Wnt1; Wnt; dWnt; fg; int-1; l(2)02657; l(2)SH1281; l(2)SH2 1281; l(2)rO727; l(2)wg; spd; wgl; wg; wnt1; wnt", "protein_names_uniprotkb": "Protein wingless; Protein Wnt-1; Protein int-1; dInt-1; dWnt-1", "protein_names_refseq": "CG4889-PA; Wg; Wnt-1; bristled; complementation group I; flag; glazed; lethal (2) SH1281; spade; sternopleural; wg-PA; wingless", "tax_id": 7227, "disease": "osteogenesis imperfecta type 15 (Disease Ontology:DOID:0110347); breast cancer (Disease Ontology:DOID:1612); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG4889); (R-DME-201681); (R-DME-209387); (R-DME-209440); (R-DME-209472); (R-DME-3238698); (R-DME-4086400); (R-DME-4641262)", "pathway_count": 8, "publication_count": 37, "publication_id_list": "10196136;10421629;10731132;10846164;10949033;11336703;11717401;11821428;12205098;12537569;12537572;12636921;12781135;1335365;14636582;14731402;15166250;15459103;15875013;16163385;16341016;16987508;18193032;18193037;19837038;25360738;25731175;2582493;26974662;3111720;3129722;34580289;41298547;7529201;7954794;8262072;8717036", "class_list": "", "function": "Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, and diffuses long distances despite its lipidation. Lipophorin is required for diffusion, probably by acting as vehicle for its movement, explaining how it can spread over long distances despite its lipidation. In non-neuronal cells, wls directs wg secretion via clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps26 and Vps35) to sustain a wls traffic loop encompassing the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi. In neuronal cells (the larval motorneuron NMJ), wg signal moves across the synapse through the release of wls-containing exosome-like vesicles. Required in both neural stem cells and glial cells of the larval brain for reactivation of quiescent neural stem cells (PubMed:41298547)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q27768;Q27769;Q8IPI1;Q8MQP9;Q9VM27", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005125 cytokine activity;GO:0050840 extracellular matrix binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0007418 ventral midline development;GO:0007442 hindgut morphogenesis;GO:0048332 mesoderm morphogenesis;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P09615-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09774-1", "uniprot_id": "AST3_DROME", "mass": 28972.0, "length": 257, "protein_name": "Achaete-scute complex protein T3", "gene_name": "l(1)sc", "organism": "Fruit fly", "refseq_name": "lethal of scute", "refseq_ac": "NP_476623", "gene_names_uniprotkb": "l(1)sc; CG3839; T3; l'sc", "gene_names_refseq": "AS-C T3; AS-T3; ASC-T3; CG3839; Dmel\\CG3839; EG:198A6.2; L'Sc; L'sc; L(1)sc; T3; ascT3; bHLHc28; l'sc; l(1)1Ba; l(1)sc; l-sc; l[1]sc; lsc; sc/T3", "protein_names_uniprotkb": "Achaete-scute complex protein T3; Lethal of sc; Protein lethal of scute", "protein_names_refseq": "CG3839-PA; Lethal(1)scute; Lethal-scute; l(1)sc-PA; lethal at scute; lethal of scute", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (dme:Dmel_CG3839)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10731137;12537569;12537572;2461300;8076513", "class_list": "", "function": "AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24387;Q8MRA5", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0045893 positive regulation of DNA-templated transcription;GO:0030182 neuron differentiation;GO:0007422 peripheral nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09774-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09775-1", "uniprot_id": "AST8_DROME", "mass": 53223.0, "length": 486, "protein_name": "Achaete-scute complex protein T8", "gene_name": "ase", "organism": "Fruit fly", "refseq_name": "asense", "refseq_ac": "NP_476694", "gene_names_uniprotkb": "ase; CG3258; T8", "gene_names_refseq": "AS-C T8ase; AS-C T8; AS-T8; ASC; Asense; Ase; CG3258; Dmel\\CG3258; EG:165H7.2; T1A; T1a; T1; T8; as-T8; ascT8; ase; bHLHc28; sc/T8", "protein_names_uniprotkb": "Achaete-scute complex protein T8; Protein asense", "protein_names_refseq": "CG3258-PA; ase-PA; asense", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (dme:Dmel_CG3258)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10731137;12537569;12537572;2461300;2510998", "class_list": "", "function": "Involved in the determination of the neuronal precursors of optic lobes in the central nervous system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q541C1;Q9W5G2", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007422 peripheral nervous system development;GO:0045839 negative regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09775-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09957-1", "uniprot_id": "YELL_DROME", "mass": 60520.0, "length": 541, "protein_name": "Protein yellow", "gene_name": "y", "organism": "Fruit fly", "refseq_name": "yellow", "refseq_ac": "NP_476792", "gene_names_uniprotkb": "y; CG3757", "gene_names_refseq": "CG3757; Dmel\\CG3757; EG:125H10.2; T6; Y; y", "protein_names_uniprotkb": "Protein yellow", "protein_names_refseq": "CG3757-PA; y-PA; yellow", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3757)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10731137;12537572;16052739;3096713", "class_list": "", "function": "Controls the pigmentation pattern of the adult cuticle and larval mouth parts., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9W5G5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0070451 cell hair", "go_biological_process": "GO:0060179 male mating behavior;GO:0042438 melanin biosynthetic process;GO:0048066 developmental pigmentation;GO:0006583 melanin biosynthetic process from tyrosine;GO:0048067 cuticle pigmentation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09957-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DKM0-1", "uniprot_id": "COA3_DROME", "mass": 9862.0, "length": 87, "protein_name": "Cytochrome c oxidase assembly factor 3, mitochondrial", "gene_name": "Ccdc56", "organism": "Fruit fly", "refseq_name": "Coiled-coil domain containing 56", "refseq_ac": "NP_996062", "gene_names_uniprotkb": "Ccdc56; CG42630", "gene_names_refseq": "CCDC56; CG42630; CG7319; Ccdc56; Coa3; Dmel\\CG42630; ccdc56", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 3, mitochondrial; Coiled-coil domain-containing protein 56 homolog", "protein_names_refseq": "CG42630-PA; CPuORF of FBgn0261381; Ccdc56-PA; Coiled-coil domain containing 56; mitochondrial transcription factor B1", "tax_id": 7227, "disease": "mitochondrial complex IV deficiency nuclear type 14 (Disease Ontology:DOID:0070499)", "pathway": " (dme:Dmel_CG42630); (R-DME-9864848)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;22610097", "class_list": "", "function": "Plays a critical role in the biogenesis and activity of cytochrome c oxidase (COX) (complex IV)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "N0BIP9", "ec_number_list": "", "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0DKM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10083-1", "uniprot_id": "AST5_DROME", "mass": 22753.0, "length": 201, "protein_name": "Achaete-scute complex protein T5", "gene_name": "ac", "organism": "Fruit fly", "refseq_name": "achaete", "refseq_ac": "NP_476824", "gene_names_uniprotkb": "ac; CG3796; T5", "gene_names_refseq": "990 E5 F1; AC; AS-C T5ac; AS-C T5; AS-C; ASC; Achaete; Ac; CG3796; Dmel\\CG3796; EG:125H10.3; Hw; T5; achaete-scute; ac; ascT5; sc/T5", "protein_names_uniprotkb": "Achaete-scute complex protein T5; Protein achaete", "protein_names_refseq": "Achaete/Scute; CG3796-PA; Hairy-wing; ac-PA; achaete-scute; achaete; acheate; achete; asc; hairy wing", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3796)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731137;12537572;3111716", "class_list": "", "function": "AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V702;Q9W5G4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007417 central nervous system development;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P10083-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10084-1", "uniprot_id": "AST4_DROME", "mass": 38155.0, "length": 345, "protein_name": "Achaete-scute complex protein T4", "gene_name": "sc", "organism": "Fruit fly", "refseq_name": "scute", "refseq_ac": "NP_476803", "gene_names_uniprotkb": "sc; CG3827; T4; sis-b", "gene_names_refseq": "AS-C T4sc; AS-C T4; CG3827; DROACS2; Dmel\\CG3827; EG:198A6.1; Hw; SC_DA; Scute; Sc; T4 AS-C; T4; ascT4; bHLHc28; l(1)1Ba; sc/T4; scalpha; scute/sisterlessB; sc; sis b; sis-b; sisB; sisb", "protein_names_uniprotkb": "Achaete-scute complex protein T4; Protein scute", "protein_names_refseq": "Achaete/Scute; CG3827-PA; Hairy-wing; achaete-scute; asc; sc-PA; scute alpha; scute-T4-transcript; scute/sisterless-b; scute; sisterless-b", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (dme:Dmel_CG3827)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;10731137;12537572;16083904;2583094;3111716;7651341;8370520", "class_list": "", "function": "AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Also involved in sex determination and dosage compensation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O76890;Q4V705", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007530 sex determination;GO:0007399 nervous system development;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10084-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10383-1", "uniprot_id": "OTU_DROME", "mass": 97452.0, "length": 853, "protein_name": "Deubiquitinase otu", "gene_name": "otu", "organism": "Fruit fly", "refseq_name": "ovarian tumor, isoform D", "refseq_ac": "NP_001259332", "gene_names_uniprotkb": "otu; CG12743", "gene_names_refseq": "CG12743; DROOTUA; Dmel\\CG12743; K; OTU; Otu; fs(1)231; fs(1)23l; fs(1)M101; fs(1)jA265; fs(1)otu; otu", "protein_names_uniprotkb": "Deubiquitinase otu; 3.4.19.-; Protein ovarian tumor", "protein_names_refseq": "CG12743-PD; otu-PD; ovarian tumor, isoform D; ovarian tumor; ovarian tumour", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 36 (Disease Ontology:DOID:0080470)", "pathway": " (dme:Dmel_CG12743)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10101125;10731132;11287191;12537569;12537572;15056611;1737618;2498839;2511440;26588485;28484036;30879902;37027460;40215271;7851643;8436274;9344535", "class_list": "", "function": "Catalytic component of a deubiquitinase complex consisting of bam and otu (PubMed:26588485, PubMed:28484036). The complex deubiquitinates K63-linked polyubiquitinated proteins; this antagonizes the ubiquitination activity of Traf6 and regulates the IMD immune signaling pathway (PubMed:30879902). Otu-bam deubiquitinase activity is regulated by Traf6 dependent immune signaling regulation of bam expression levels; this forms a feedback loop that regulates the IMD immune signaling pathway and balances gut immune activity during aging (PubMed:30879902). The complex deubiquitinates and stabilizes CycA/cyclin-A to regulate CycA-dependent differentiation (PubMed:28484036, PubMed:40215271). Part of a complex with bbn and MycBP (PubMed:40215271). Involved in grk mRNA localization to the dorsal anterior region of the oocyte required for dorsal-ventral axis determination; may function as a ribonuclear protein complex together with sqd and Hrb27C (PubMed:15056611). May regulate actin cytoskeleton organization in differentiating cystocytes during fusome maturation; required for efficient nurse cell cytoplasmic dumping during oogenesis (PubMed:9344535). Essential for female fertility; involved in germ cell proliferation and germ cell differentiation, probably as part of a complex with bbn and Mycbp (PubMed:1737618, PubMed:28484036, PubMed:40215271, PubMed:7851643, PubMed:8436274)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Involved in the early stages of germ cell proliferation and differentiation during oogenesis (PubMed:7851643). Required for polytene chromosome dispersal in nurse cells during oogenesis (PubMed:15056611, PubMed:1737618)., [UniProtKB, PubMed, PubMed, PubMed]; Involved in the later stages of germ cell proliferation and differentiation during oogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4V451;Q8SYF4;Q9GYD8;Q9TWA9;Q9W3E4", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0061578 K63-linked deubiquitinase activity;GO:0008236 serine-type peptidase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005938 cell cortex;GO:0048471 perinuclear region of cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0032877 positive regulation of DNA endoreduplication;GO:0030036 actin cytoskeleton organization;GO:0050821 protein stabilization;GO:0009966 regulation of signal transduction;GO:2000738 positive regulation of stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P10383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10735-1", "uniprot_id": "RT12_DROME", "mass": 15532.0, "length": 140, "protein_name": "Small ribosomal subunit protein uS12m", "gene_name": "tko", "organism": "Fruit fly", "refseq_name": "technical knockout, isoform C", "refseq_ac": "NP_001245490", "gene_names_uniprotkb": "tko; CG7925", "gene_names_refseq": "CG7925; Dmel\\CG7925; EG:BACH59J11.1; MRP-S12; MRPS12; S12; Tko; l(1)3Ab; l(1)tko; mRpS12; mt-rps12; rps12; tko", "protein_names_uniprotkb": "Small ribosomal subunit protein uS12m; 40S ribosomal protein S12, mitochondrial; MRP-S12; MT-RPS12; Protein technical knockout locus; S12mt", "protein_names_refseq": "CG7925-PC; mitochondrial ribosomal protein S12; mitoribosomal protein S12; technical knockout, isoform C; technical knockout; tko-PC", "tax_id": 7227, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG7925); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;10731137;12537572;16120347;3117373", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U1D4;Q9NEH6;Q9U1J6;Q9V3R2", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005840 ribosome", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007638 mechanosensory behavior;GO:0001666 response to hypoxia;GO:0009612 response to mechanical stimulus;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10987-1", "uniprot_id": "ACT1_DROME", "mass": 41822.0, "length": 376, "protein_name": "Actin-5C", "gene_name": "Act5C", "organism": "Fruit fly", "refseq_name": "actin 5C, isoform D", "refseq_ac": "NP_001014725", "gene_names_uniprotkb": "Act5C; A4V404_DROME; ACT1_DROME; ACT5C; ACT; Ac5C; Act-5C; Act5c; Act5; Actin5C; Actin; Act; ArpA; A; BAP47; Bap47; CG4027; Dmel\\CG4027; Dmel_CG4027; F-ACTIN; F-Actin; F-actin; G-actin; M32055; T11; act 5C; act5C; actin5C; actin; actomyosin; act; anon-EST:fe2D2; beta-Actin; beta-actin; chrX:5748184..5748304; cyt5C; f-actin; l(1)G0009; l(1)G0010; l(1)G0025; l(1)G0079; l(1)G0117; l(1)G0177; l(1)G0245; l(1)G0330; l(1)G0420; l(1)G0486", "gene_names_refseq": "A4V404_DROME; ACT1_DROME; ACT5C; ACT; Ac5C; Act-5C; Act5C; Act5c; Act5; Actin/BAP47; Actin5C; Actin; Act; ArpA; A; BAP47; Bap47; CG4027; Dmel\\CG4027; F-ACTIN; F-Actin; F-actin; G-actin; M32055; T11; act 5C; act5C; actin5C; actin; actomyosin; act; anon-EST:fe2D2; beta-Actin; beta-actin/Bap47; beta-actin; chrX:5748184..5748304; cyt5C; f-actin; l(1)G0009; l(1)G0010; l(1)G0025; l(1)G0079; l(1)G0117; l(1)G0177; l(1)G0245; l(1)G0330; l(1)G0420; l(1)G0486", "protein_names_uniprotkb": "Actin-5C; 3.6.4.-", "protein_names_refseq": "5C actin; Act5C-PD; CG4027-PD; Dm-actin5C; F-actin; G-actin; actin 5 C; actin 5C, isoform D; actin 5c; actin A1; actin5C; anon-fast-evolving-2D2; cellular cytoskeletal beta-actin", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Baraitser-Winter syndrome 2 (Disease Ontology:DOID:0081113); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); hand, foot and mouth disease (Disease Ontology:DOID:10881); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); thrombocytopenia (Disease Ontology:DOID:1588); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dme:Dmel_CG4027); (R-DME-114608); (R-DME-190873); (R-DME-196025); (R-DME-2029482); (R-DME-3928662); (R-DME-3928665); (R-DME-437239); (R-DME-4420097); (R-DME-445095); (R-DME-446353); (R-DME-5663213); (R-DME-5689603); (R-DME-5696394); (R-DME-8856828); (R-DME-9013418); (R-DME-9035034); (R-DME-9764561); (R-DME-9913351); (R-DME-9933937); (R-DME-9933939); (R-DME-9933946); (R-DME-9933947); (R-DME-9934037); (R-DME-9958825)", "pathway_count": 25, "publication_count": 19, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22116028;22928698;25589440;26109356;26109357;2896018;3097509;3123314;6263481;9344535", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V404;Q24227;Q6YN46;Q9U5X7;Q9W460", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.1.3.56;3.6.5.2;2.7.10.1;3.6.5.5;3.6.4.10;3.6.4.6;2.7.11.1;3.6.4.12;5.6.2.4;2.3.2.27;5.6.2.5;1.15.1.1;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.1.3.95;3.-.-.-;5.6.1.1;3.6.-.-;5.6.2.-;3.4.-.-;3.4.19.12;2.3.2.26", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0015629 actin cytoskeleton;GO:0031011 Ino80 complex;GO:0035060 brahma complex;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0006338 chromatin remodeling;GO:0000281 mitotic cytokinesis;GO:0035148 tube formation;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P10987-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11346-1", "uniprot_id": "KRAF1_DROME", "mass": 83729.0, "length": 739, "protein_name": "Raf homolog serine/threonine-protein kinase Raf", "gene_name": "Raf", "organism": "Fruit fly", "refseq_name": "Raf oncogene, isoform E", "refseq_ac": "NP_001096867", "gene_names_uniprotkb": "Raf; CG2845; phl; ph", "gene_names_refseq": "11-29; C110; CG2845; D-RAF; D-Raf; D-raf1; D-raf; DRaf1; DRaf; Dmel\\CG2845; Draf-1; Draf1; Draf; EG:BACH48C10.3; Phl; RAF; Raf/phl; Raf1; Raf; dRaf; draf; l(1)2Fe; l(1)G0475; l(1)phl; l(1)ph; l(1)pole hole; l(1)polehole/draf; l(1)polehole; l(1)raf; lincRNA.937; ph1; phl; ph; raf-1; raf1; rafl; raf", "protein_names_uniprotkb": "Raf homolog serine/threonine-protein kinase Raf; 2.7.11.1; D-Raf; Protein pole-hole; dRAF-1", "protein_names_refseq": "CG2845-PE; Raf oncogene, isoform E; Raf-PE; l(1)pole hole; pole-hole; polehole; raf-like-oncogene-1", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); cardiofaciocutaneous syndrome (Disease Ontology:DOID:0060233); Noonan syndrome 5 (Disease Ontology:DOID:0060583); Noonan syndrome 7 (Disease Ontology:DOID:0060585); Noonan syndrome with multiple lentigines 2 (Disease Ontology:DOID:0080549); Noonan syndrome with multiple lentigines 3 (Disease Ontology:DOID:0080550); dilated cardiomyopathy 1NN (Disease Ontology:DOID:0110432); cardiofaciocutaneous syndrome 1 (Disease Ontology:DOID:0111460); prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); prostate adenocarcinoma (Disease Ontology:DOID:2526); Langerhans-cell histiocytosis (Disease Ontology:DOID:2571); dysembryoplastic neuroepithelial tumor (Disease Ontology:DOID:2679); endometrial carcinoma (Disease Ontology:DOID:2871); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); germinoma (Disease Ontology:DOID:3304); Noonan syndrome (Disease Ontology:DOID:3490); papillary thyroid carcinoma (Disease Ontology:DOID:3969); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); pleomorphic xanthoastrocytoma (Disease Ontology:DOID:4852); pancreatic carcinoma (Disease Ontology:DOID:4905); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); cholangiocarcinoma (Disease Ontology:DOID:4947); bile duct adenoma (Disease Ontology:DOID:5381); pancreatic acinar cell adenocarcinoma (Disease Ontology:DOID:5742); familial melanoma (Disease Ontology:DOID:6846); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG2845); (R-DME-1295596); (R-DME-170968); (R-DME-209190); (R-DME-209214); (R-DME-392517); (R-DME-430116); (R-DME-432553); (R-DME-5621575); (R-DME-5673000); (R-DME-5674135); (R-DME-5674499); (R-DME-5675221)", "pathway_count": 13, "publication_count": 52, "publication_id_list": "10409506;10477300;10557210;10731132;10731137;11430804;11440719;11912487;11955435;12122057;12432393;12442174;12447397;12537569;12537572;12563262;12663920;12694293;12944510;14759367;15300262;15563523;15592457;15598741;15616566;15875013;16041759;16319317;16326393;16410523;16630821;17077139;17418796;17925225;18327897;18494562;18593878;18815259;19965758;29433126;3037346;3135183;7481773;8423783;8596938;8600384;8898207;8906787;8906794;8938123;9482888;9674431", "class_list": "", "function": "Serine/threonine kinase required in the early embryo for the formation of terminal structure (PubMed:3135183, PubMed:8423783). Also required during the proliferation of imaginal cells (PubMed:3135183). May act downstream of Ras85D in the tor signal transduction pathway (PubMed:8423783). During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JUV5;Q0KHW7;Q8I086;Q8I0D9;Q8ISE1;Q8ISE2;Q8ISE3;Q9NEH9;Q9W4Z3", "ec_number_list": "2.7.11.1;2.7.11.17;2.7.11.13;2.3.2.27;2.7.11.24;2.7.11.22;2.7.11.21;3.6.5.2;5.6.1.8;2.7.11.11;2.7.11.23;3.1.3.16;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;2.7.11.39", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019900 kinase binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046534 positive regulation of photoreceptor cell differentiation;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0040014 regulation of multicellular organism growth;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "P11346-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11449-1", "uniprot_id": "VTU1_DROME", "mass": 14321.0, "length": 141, "protein_name": "Vitelline membrane protein Vm26Aa", "gene_name": "Vm26Aa", "organism": "Fruit fly", "refseq_name": "vitelline membrane 26Aa, isoform B", "refseq_ac": "NP_001260115", "gene_names_uniprotkb": "Vm26Aa; CG9048; TU-2; VM26A.1; sV17", "gene_names_refseq": "CG9048; Dmel\\CG9048; TU-2; VM26A.1; VM26Aa; Vm26A.1; Vm26A1; Vm26Aa; Vm26A; sV17", "protein_names_uniprotkb": "Vitelline membrane protein Vm26Aa; Protein SV17.5; Protein TU-2", "protein_names_refseq": "CG9048-PB; Vm26Aa-PB; vitelline membrane 26Aa, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9048)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537572;17244601;18514182;19540119;20832396;3119397;3143615;8293994", "class_list": "", "function": "Major early eggshell protein., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ49;M9PCA1;Q1RKQ5;Q9VMK4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0060388 vitelline envelope", "go_biological_process": "GO:0048477 oogenesis;GO:0007305 vitelline membrane formation involved in chorion-containing eggshell formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P11449-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11450-1", "uniprot_id": "FCP3C_DROME", "mass": 30300.0, "length": 282, "protein_name": "Follicle cell protein 3C-1", "gene_name": "Fcp3C", "organism": "Fruit fly", "refseq_name": "follicle cell protein 3C", "refseq_ac": "NP_477482", "gene_names_uniprotkb": "Fcp3C; CG4015", "gene_names_refseq": "CG4015; Dmel\\CG4015; EG:140G11.2; Ecp3C; Fcp3C; VMP3C", "protein_names_uniprotkb": "Follicle cell protein 3C-1", "protein_names_refseq": "CG4015-PA; Fcp3C-PA; follicle cell protein 3C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4015)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10731137;12537572;16020794;3119397", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97173;Q32UU7;Q32UV1;Q32UV5;Q32UV9;Q32UW7;Q32UX5;Q32UX9;Q32UY3;Q32UY7;Q32UZ9;Q32V15;Q32V31;Q32V35;Q32V47;Q32V51", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P11450-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11455-1", "uniprot_id": "TERM_DROME", "mass": 49166.0, "length": 428, "protein_name": "Protein terminus", "gene_name": "term", "organism": "Fruit fly", "refseq_name": "terminus", "refseq_ac": "NP_524882", "gene_names_uniprotkb": "term; CG4216; ter", "gene_names_refseq": "Bsg75C; CG4216; Dmel\\CG4216; Term; term; ter", "protein_names_uniprotkb": "Protein terminus", "protein_names_refseq": "CG4216-PA; term-PA; terminus", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4216)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;3334721", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VVQ3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11455-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11596-1", "uniprot_id": "TRSF_DROME", "mass": 24134.0, "length": 197, "protein_name": "Female-specific protein transformer", "gene_name": "tra", "organism": "Fruit fly", "refseq_name": "transformer, isoform A", "refseq_ac": "NP_524114", "gene_names_uniprotkb": "tra; CG16724; Dmel\\CG16724; Dmel_CG16724; Dmtra; TRA; Tra", "gene_names_refseq": "CG16724; Dmel\\CG16724; Dmtra; TRA; Tra; tra", "protein_names_uniprotkb": "Female-specific protein transformer", "protein_names_refseq": "CG16724-PA; tra-PA; transformer, isoform A; transformer", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16724)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;12644565;16110336;1655279;1690860;17569856;17569867;2441872;2503251;25589440;26109356;26109357;33109704;7680770;8013913;8334698;9418892", "class_list": "", "function": "Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl (PubMed:1690860, PubMed:2441872, PubMed:2503251, PubMed:7680770). Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins (PubMed:8334698). Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site (PubMed:9418892). No known function in males (PubMed:1690860, PubMed:2441872, PubMed:2503251, PubMed:7680770)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540G8;Q86LR9;Q9VV78", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0030154 cell differentiation;GO:0000398 mRNA splicing, via spliceosome;GO:2000035 regulation of stem cell division;GO:0030237 female sex determination;GO:0046660 female sex differentiation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P11596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13060-1", "uniprot_id": "EF2_DROME", "mass": 94459.0, "length": 844, "protein_name": "Eukaryotic translation elongation factor 2", "gene_name": "eEF2", "organism": "Fruit fly", "refseq_name": "eukaryotic translation elongation factor 2, isoform A", "refseq_ac": "NP_525105", "gene_names_uniprotkb": "eEF2; CG2238; EF2; Ef2b", "gene_names_refseq": "CG2238; Dmel\\CG2238; EF-2b; EF-2; EF2B; EF2b; EF2; Ef2B; Ef2b; Ef2; anon-EST:Liang-1.44; chr2L:21668915..21669164; clone 1.44; eEF2; eF2; ef2b", "protein_names_uniprotkb": "Eukaryotic translation elongation factor 2; 3.6.5.-; EF-2; Elongation factor 2", "protein_names_refseq": "CG2238-PA; ELONGATION FACTOR 2; eEF2-PA; eukaryotic translation elongation factor 2, isoform A; eukaryotic translation elongation factor 2b", "tax_id": 7227, "disease": "spinocerebellar ataxia 26 (Disease Ontology:DOID:0050975); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); glaucoma (Disease Ontology:DOID:1686); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); brain glioblastoma multiforme (Disease Ontology:DOID:3073); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG2238); (R-DME-156902); (R-DME-5358493); (R-DME-6798695); (R-DME-8876725)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;23636399;2508059", "class_list": "", "function": "Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A023GPJ5;Q9I7H2;Q9V9R0", "ec_number_list": "2.4.1.186;5.4.2.7;5.4.2.-;3.6.5.5;3.2.1.31;1.1.1.42;2.4.2.1;3.6.5.2;3.6.5.-;2.7.11.24;2.7.1.40;4.1.2.13;2.7.4.6;2.4.2.7;1.11.1.6;5.3.1.9;2.7.1.11;1.1.1.205;3.6.5.3;3.4.22.-;3.6.4.12;3.6.4.6;1.16.3.1;2.7.1.35;2.3.2.5;2.1.1.314;3.4.24.-;2.3.2.27;2.7.1.1;5.2.1.8;3.4.19.-;1.11.1.24;5.6.1.5;5.4.2.11;5.4.2.4;3.2.1.23;3.6.1.5;3.6.4.13;3.3.2.6;3.5.4.5;2.7.11.22;2.7.11.23;2.5.1.108;4.2.1.24;5.4.2.2;3.4.-.-;1.11.2.-;2.4.1.25;3.2.1.33;2.7.1.-;3.5.4.6;2.3.2.26", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13098-1", "uniprot_id": "ESM8_DROME", "mass": 20303.0, "length": 179, "protein_name": "Enhancer of split m8 protein", "gene_name": "E(spl)m8-HLH", "organism": "Fruit fly", "refseq_name": "enhancer of split m8, helix-loop-helix", "refseq_ac": "NP_524513", "gene_names_uniprotkb": "E(spl)m8-HLH; CG8365; E(spl); m8", "gene_names_refseq": "CG8365; Dmel\\CG8365; E(Spl); E(spl) m8; E(spl)-C; E(spl)-M8; E(spl)-m8; E(spl)M8; E(spl)bHLH; E(spl)m8-HLH; E(spl)m8; E(spl); En(spl)-C; En(spl); Enhancer of split m8; Espl; HES; HLHm8; Hes; M8; Su(H)[[m8]]; anon-EST:Liang-1.71; bHLHb36; clone 1.71; e(spl); l(3)96Fd; m8", "protein_names_uniprotkb": "Enhancer of split m8 protein; E(spl)m8", "protein_names_refseq": "CG8365-PA; E(spl)-m8; E(spl)m8-HLH-PA; Enhancer-of-split; enhancer of split m8, helix-loop-helix; enhancer of split m8; enhancer of split; enhancer-of-split-m8", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8365)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537572;15537803;16120803;22357926;2540957;8001118", "class_list": "", "function": "Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo (PubMed:2540957). Transcriptional repressor (PubMed:8001118). Binds DNA on N-box motifs: 5'-CACNAG-3' (PubMed:8001118). Part of the Notch signaling pathway (PubMed:22357926)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0IGQ3;Q2XYK0;Q5S426;Q5S462;Q5S474;Q5S4H0;Q5S4I2;Q9VBI5", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048749 compound eye development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P13098-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13368-1", "uniprot_id": "7LESS_DROME", "mass": 287025.0, "length": 2554, "protein_name": "Protein sevenless", "gene_name": "sev", "organism": "Fruit fly", "refseq_name": "sevenless", "refseq_ac": "NP_511114", "gene_names_uniprotkb": "sev; CG18085; HD-265", "gene_names_refseq": "7LES; 7less; CG18085; CT3980; DROSEV1; DROSEV; DmHD-265; Dmel\\CG18085; HD-265; SEV; Sev; sev(AC)[[14]]; sev", "protein_names_uniprotkb": "Protein sevenless; 2.7.10.1", "protein_names_refseq": "CG18085-PA; sev-PA; sevenless", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18085)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537572;2317871;2840202;3138161;9671493;9731193", "class_list": "", "function": "Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell., [UniProtKB, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 8, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q9TYI0;Q9U5V7;Q9VZ36", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.12.1;2.7.12.2;2.7.11.22;2.7.11.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0008288 boss receptor activity;GO:0019199 transmembrane receptor protein kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007601 visual perception;GO:0032006 regulation of TOR signaling;GO:0007465 R7 cell fate commitment;GO:0045500 sevenless signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P13368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13677-1", "uniprot_id": "KPC2_DROME", "mass": 79844.0, "length": 700, "protein_name": "Protein kinase C, eye isozyme", "gene_name": "inaC", "organism": "Fruit fly", "refseq_name": "inactivation no afterpotential C", "refseq_ac": "NP_476863", "gene_names_uniprotkb": "inaC; CG6518; PKC2", "gene_names_refseq": "CG6518; Dmel\\CG6518; Dpkc2; INAC; InaC; PK-C; PKC 53E; PKC2; PKCinac; PKCi; PKC; Pkc2; dPKC53E(ey); dPKC53E; ePKC; eye PKC; eye-PKC; eyePKC; inaC; inac; pkc-2", "protein_names_uniprotkb": "Protein kinase C, eye isozyme; 2.7.11.13; Eye-PKC; Inactivation no after-potential C protein; Photoreceptor-specific PKC; Protein INAC; dPKC53E(EY)", "protein_names_refseq": "CG6518-PA; PKC-eye; Protein-kinase-2; eye-PKC; eye-protein-kinase C; eye-specific PKC; inaC-PA; inactivation no afterpotential C; protein kinase C; protein kinase-c2; protein-kinase-C", "tax_id": 7227, "disease": "spinocerebellar ataxia 14 (Disease Ontology:DOID:0050964); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate carcinoma (Disease Ontology:DOID:10286); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); middle cerebral artery infarction (Disease Ontology:DOID:3525); chordoid glioma (Disease Ontology:DOID:3774); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); hyperglycemia (Disease Ontology:DOID:4195); large cell carcinoma (Disease Ontology:DOID:4552); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG6518); (R-DME-111933); (R-DME-114516); (R-DME-1169091); (R-DME-1250196); (R-DME-1433559); (R-DME-2179392); (R-DME-3000170); (R-DME-399997); (R-DME-416993); (R-DME-4419969); (R-DME-450520); (R-DME-5218921); (R-DME-76005)", "pathway_count": 14, "publication_count": 5, "publication_id_list": "10731132;11342563;12537572;25639794;2720775", "class_list": "", "function": "This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9V7V5", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.10.1;2.7.11.22;2.7.11.21;5.6.1.8;2.7.11.11;2.7.11.23;2.7.11.-;2.7.11.16;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;3.4.24.-;2.7.10.2;2.7.11.39;2.7.1.91", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0016028 rhabdomere;GO:0016027 inaD signaling complex", "go_biological_process": "GO:0016477 cell migration;GO:0019722 calcium-mediated signaling;GO:0035556 intracellular signal transduction;GO:0045471 response to ethanol;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13677-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14003-1", "uniprot_id": "HAIR_DROME", "mass": 37005.0, "length": 337, "protein_name": "Protein hairy", "gene_name": "hry", "organism": "Fruit fly", "refseq_name": "hairy, isoform B", "refseq_ac": "NP_001014577", "gene_names_uniprotkb": "hry; CG6494; h", "gene_names_refseq": "8247; CG6494; Dmel\\CG6494; HRY; Hairy; H; bHLHb39; bHLHc14; brr; dDr1; hry; h; l(3)08247; l(3)rM384", "protein_names_uniprotkb": "Protein hairy", "protein_names_refseq": "CG6494-PB; barrel; hairy, isoform B; hairy; hry-PB", "tax_id": 7227, "disease": "hemangiopericytoma (Disease Ontology:DOID:264); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dme:Dmel_CG6494)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12242230;12537569;12537572;14871887;2479541;8001118;8649374", "class_list": "", "function": "Pair-rule protein that regulates embryonic segmentation and adult bristle patterning. Transcriptional repressor of genes that require a bHLH protein for their transcription (e.g. ftz)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1N7;Q95NH3;Q95NU9;Q9VSN8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0001666 response to hypoxia;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P14003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14199-1", "uniprot_id": "REF2P_DROME", "mass": 65303.0, "length": 599, "protein_name": "Protein ref(2)P", "gene_name": "ref(2)P", "organism": "Fruit fly", "refseq_name": "refractory to sigma P, isoform B", "refseq_ac": "NP_001014491", "gene_names_uniprotkb": "ref(2)P; CG10360", "gene_names_refseq": "CG10360; Dmel\\CG10360; P62; Ref(2)P/p62; Ref(2)P; Ref(2)p; Ref(2P); Ref2(P); Ref2P; Ref2p; Ref2; SQSTM1; dP62; p62/Ref(2)P; p62; p63; ref(2)Pn; ref(2)Po2; ref(2)P; ref(2)p; ref2p; ref", "protein_names_uniprotkb": "Protein ref(2)P; Refractory to sigma P", "protein_names_refseq": "CG10360-PB; p62 polyubiquitin; ref(2)P-PB; refractaire(2)Paris; refractory to sigma P, isoform B; refractory to sigma P; sequestosome-1; sequestosome", "tax_id": 7227, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); distal myopathy with rimmed vacuoles (Disease Ontology:DOID:0081363); neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset (Disease Ontology:DOID:0081364); Paget's disease of bone 3 (Disease Ontology:DOID:0081366); frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (Disease Ontology:DOID:0110068); hypertension (Disease Ontology:DOID:10763); glaucoma (Disease Ontology:DOID:1686); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Paget's disease of bone (Disease Ontology:DOID:5408); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dme:Dmel_CG10360); (R-DME-5205685); (R-DME-9664873); (R-DME-9755511)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10731132;12446795;12537572;17550883;18327897;22622177;2510997;8462852;8583891", "class_list": "", "function": "Required for selective autophagy activation by ubiquitinated proteins (PubMed:22622177). Implicated in sigma rhabdovirus multiplication and necessary for male fertility. Involved in activating transcription of Drs (PubMed:12446795, PubMed:2510997)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6PX28;A6PX29;A6PX30;A6PX31;A6PX32;A6PX33;A6PX35;A6PX37;A6PX38;A6PX44;A6PX45;A6PX46;A6PX51;A6PX56;A6PX61;A6PX72;A6PX73;A6PX89;A6PX90;A6PXA2;A6PXA4;A6PXB0;A6PXB1;Q04576;Q04577;Q04578;Q24063;Q24064;Q24065;Q24066;Q24067;Q24068;Q24069;Q24070;Q24071;Q24072;Q541D1;Q9VIU1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0005080 protein kinase C binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005776 autophagosome;GO:0016235 aggresome;GO:0044753 amphisome", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0006351 DNA-templated transcription;GO:0016236 macroautophagy;GO:0007032 endosome organization;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P14199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P15357-1", "uniprot_id": "RS27A_DROME", "mass": 17940.0, "length": 156, "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RpS27A", "organism": "Fruit fly", "refseq_name": "ribosomal protein S27A", "refseq_ac": "NP_476778", "gene_names_uniprotkb": "RpS27A; CG5271; UB3-D; UBI-F80; Ubi-m", "gene_names_refseq": "CG5271; DUb80; Dmel\\CG5271; Dub80; RpS27A; RpS27; S31e; UB3-D; Ubi-f80; Ubi-m; Ubiq; l(2)04820; l(2)31Ei; mfs(2)31; mfs(2)48; mfs48", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eS31 fusion protein; 40S ribosomal protein S27a", "protein_names_refseq": "CG5271-PA; RpS27A-PA; Ubiquitin-monomeric; male female sterile 31; ribosomal protein S27A; ubiquitin fusion 80; ubiquitin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5271); (R-DME-110312); (R-DME-110314); (R-DME-110320); (R-DME-1169091); (R-DME-1234176); (R-DME-1253288); (R-DME-1295596); (R-DME-1358803); (R-DME-174048); (R-DME-174084); (R-DME-174113); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-179409); (R-DME-182971); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209447); (R-DME-209461); (R-DME-209560); (R-DME-2122948); (R-DME-214399); (R-DME-216167); (R-DME-2173788); (R-DME-2173791); (R-DME-2173795); (R-DME-2173796); (R-DME-2467813); (R-DME-2559582); (R-DME-2565942); (R-DME-2871837); (R-DME-3134975); (R-DME-3769402); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-445989); (R-DME-450302); (R-DME-450321); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5205685); (R-DME-532668); (R-DME-5357905); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5654726); (R-DME-5654727); (R-DME-5654732); (R-DME-5654733); (R-DME-5655862); (R-DME-5656121); (R-DME-5656169); (R-DME-5675221); (R-DME-5675482); (R-DME-5676590); (R-DME-5689603); (R-DME-5689877); (R-DME-5689880); (R-DME-5689896); (R-DME-5689901); (R-DME-5696394); (R-DME-5696395); (R-DME-5696400); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6804757); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69231); (R-DME-69601); (R-DME-75815); (R-DME-8849469); (R-DME-8854050); (R-DME-8856825); (R-DME-8856828); (R-DME-8863795); (R-DME-8866427); (R-DME-8866652); (R-DME-8866654); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948747); (R-DME-8948751); (R-DME-8951664); (R-DME-901032); (R-DME-9010553); (R-DME-9020702); (R-DME-9033241); (R-DME-912631); (R-DME-917729); (R-DME-917937); (R-DME-937039); (R-DME-937042); (R-DME-937072); (R-DME-9646399); (R-DME-9648002); (R-DME-9664873); (R-DME-975144); (R-DME-975163); (R-DME-9755511); (R-DME-9762114); (R-DME-9770562); (R-DME-983168); (R-DME-9861718); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709); (R-DME-9954716); (R-DME-9958825)", "pathway_count": 124, "publication_count": 35, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11018014;11585911;12231619;12432393;12442174;12537572;12732719;14519762;15178801;15258584;15331761;16081424;16299518;16311020;16326393;16386907;16651542;16740475;16794082;16894030;17102630;17158449;17925225;18519643;18593878;19185492;23636399;2463465;8068011;9215627", "class_list": "", "function": "Component of the 40S subunit of the ribosome. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P68198;Q0E8I1;Q9VKW6;Q9VQX7;Q9VZL4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P15357-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16163-1", "uniprot_id": "URIC_DROME", "mass": 40062.0, "length": 352, "protein_name": "Uricase", "gene_name": "Uro", "organism": "Fruit fly", "refseq_name": "urate oxidase", "refseq_ac": "NP_476779", "gene_names_uniprotkb": "Uro; CG7171; UO", "gene_names_refseq": "CG7171; Dm UO; Dmel\\CG7171; OU; UOX; UO; URO; Uo; Uro; anon-WO0140519.210; uro", "protein_names_uniprotkb": "Uricase; 1.7.3.3; Urate oxidase", "protein_names_refseq": "CG7171-PA; Uro-PA; urate oxidase", "tax_id": 7227, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); gout (Disease Ontology:DOID:13189); hyperuricemia (Disease Ontology:DOID:1920)", "pathway": " (dme:Dmel_CG7171)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;2118989", "class_list": "", "function": "Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QG8;Q9VLX4", "ec_number_list": "1.7.3.3", "go_molecular_function": "GO:0004846 urate oxidase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006145 purine nucleobase catabolic process;GO:0019428 allantoin biosynthetic process;GO:0019628 urate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P16163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16378-1", "uniprot_id": "GNAO_DROME", "mass": 40476.0, "length": 354, "protein_name": "G protein alpha o subunit", "gene_name": "Galphao", "organism": "Fruit fly", "refseq_name": "G protein alpha subunit o, isoform A", "refseq_ac": "NP_523684", "gene_names_uniprotkb": "Galphao; CG2204; G-oa47A; G-oalpha47A", "gene_names_refseq": "Bkh; CG2204; DG[[o]]; DGalpha0; DGalpha[[o]]; DROGPAD; Dmel\\CG2204; G(o)alpha47A; G-alpha-47A; G-oalpha47A; G-oalpha47a; G-oalpha; G[[o]]alpha; G[[o]]; G[[oalpha]]; Galpha47A; Galpha[[047A]]; Galpha[[0]]; Galpha[[o]]47A; Galpha[[o]]; Galphai/o; Galphao47A; Galphao; Go-alpha; Goalpha-47A; Goalpha47a; Goalpha; Goa; Go; alpha(o); bkh; dGalphao; dgoalpha; dgo; drogpad; goalpha; like GNAO", "protein_names_uniprotkb": "G protein alpha o subunit; Guanine nucleotide-binding protein G(o) subunit alpha 47A", "protein_names_refseq": "CG2204-PA; G protein alpha o subunit; G protein alpha subunit o, isoform A; G protein o alpha 47A; G protein oalpha 47A; Galphao-PA; brokenhearted; brokenheart; drogpad", "tax_id": 7227, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 17 (Disease Ontology:DOID:0080450); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); neurodevelopmental disorder with involuntary movements (Disease Ontology:DOID:0112276); McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (dme:Dmel_CG2204)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10079238;10731132;12537569;12537572;2509462;2509463;2509464;2519611", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphai and the G protein-coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZB6;A4UZC1;B7FF70;P16377;P16707;Q540V8;Q8IGI5;Q9V5L5;Q9V5L6", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0042595 behavioral response to starvation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0019722 calcium-mediated signaling;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P16378-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18101-1", "uniprot_id": "RL40_DROME", "mass": 14729.0, "length": 128, "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "RpL40", "organism": "Fruit fly", "refseq_name": "ribosomal protein L40, isoform B", "refseq_ac": "NP_001260018", "gene_names_uniprotkb": "RpL40; CG2960; UBI-F52; Ubi-f", "gene_names_refseq": "BcDNA:RE10554; CEP52; CG2960; DUb52; Dmel\\CG2960; Dub52; L40e; L40; RPL40; RpL40; Rpl40; Ub52; Ubi-f52; Ubi-f; Ubiq", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40 fusion protein; 60S ribosomal protein L40; CEP52", "protein_names_refseq": "CG2960-PB; RpL40-PB; ribosomal protein L40, isoform B; ubiquitin 52-AA extension protein; ubiquitin fusion 52", "tax_id": 7227, "disease": "colon carcinoma (Disease Ontology:DOID:1520)", "pathway": " (dme:Dmel_CG2960); (R-DME-110312); (R-DME-110314); (R-DME-110320); (R-DME-1169091); (R-DME-1234176); (R-DME-1253288); (R-DME-1295596); (R-DME-1358803); (R-DME-156827); (R-DME-174048); (R-DME-174084); (R-DME-174113); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-179409); (R-DME-1799339); (R-DME-182971); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209447); (R-DME-209461); (R-DME-209560); (R-DME-2122948); (R-DME-214399); (R-DME-2173788); (R-DME-2173791); (R-DME-2173795); (R-DME-2173796); (R-DME-2467813); (R-DME-2559582); (R-DME-2565942); (R-DME-2871837); (R-DME-3134975); (R-DME-3769402); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-445989); (R-DME-450302); (R-DME-450321); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5205685); (R-DME-532668); (R-DME-5357905); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5654726); (R-DME-5654727); (R-DME-5654732); (R-DME-5654733); (R-DME-5655862); (R-DME-5656121); (R-DME-5656169); (R-DME-5675221); (R-DME-5675482); (R-DME-5676590); (R-DME-5689603); (R-DME-5689877); (R-DME-5689880); (R-DME-5689896); (R-DME-5689901); (R-DME-5696394); (R-DME-5696395); (R-DME-5696400); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6804757); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69231); (R-DME-69601); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-75815); (R-DME-8849469); (R-DME-8854050); (R-DME-8856825); (R-DME-8856828); (R-DME-8863795); (R-DME-8866427); (R-DME-8866652); (R-DME-8866654); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948747); (R-DME-8948751); (R-DME-8951664); (R-DME-901032); (R-DME-9010553); (R-DME-9020702); (R-DME-9033241); (R-DME-912631); (R-DME-917729); (R-DME-917937); (R-DME-937039); (R-DME-937042); (R-DME-937072); (R-DME-9646399); (R-DME-9648002); (R-DME-9664873); (R-DME-975144); (R-DME-975163); (R-DME-9755511); (R-DME-975956); (R-DME-975957); (R-DME-9762114); (R-DME-9770562); (R-DME-983168); (R-DME-9861718); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716); (R-DME-9958825)", "pathway_count": 133, "publication_count": 31, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11018014;11585911;12231619;12432393;12442174;12537572;12732719;1381584;14519762;15178801;15258584;16081424;16299518;16311020;16326393;16386907;16794082;16894030;17158449;17925225;18519643;18593878;19185492;2165256;23636399;9215627", "class_list": "", "function": "Component of the 60S subunit of the ribosome., [UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P68198;Q0E8I1;Q9VKW6;Q9VQX7;Q9VZL4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006412 translation;GO:0019941 modification-dependent protein catabolic process;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P18101-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18168-1", "uniprot_id": "SERR_DROME", "mass": 150766.0, "length": 1407, "protein_name": "Protein serrate", "gene_name": "Ser", "organism": "Fruit fly", "refseq_name": "serrate, isoform B", "refseq_ac": "NP_001287558", "gene_names_uniprotkb": "Ser; Bd; CG6127; Rpw", "gene_names_refseq": "Bd; CG6127; CT18858; Dmel\\CG6127; Rpw; SER; Ser; mel(3)8; ser; std", "protein_names_uniprotkb": "Protein serrate; Delta-like protein; Protein beaded", "protein_names_refseq": "CG6127-PB; Ser-PB; beaded; dmSerrate; ripped wing; serrate, isoform B; serrate; serratoid", "tax_id": 7227, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); autosomal recessive limb-girdle muscular dystrophy type 27 (Disease Ontology:DOID:0061133); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); congenital heart disease (Disease Ontology:DOID:1682); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); Alagille syndrome (Disease Ontology:DOID:9245)", "pathway": " (dme:Dmel_CG6127); (R-DME-2979096); (R-DME-9013149); (R-DME-9013423)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10731132;12537572;15760269;15829515;18327897;1840519;20176925;2125287", "class_list": "", "function": "Putative Notch ligand involved in the mediation of Notch signaling (By similarity). Interacts with glycosphingolipids, specifically N5 (GalNAc-alpha1-4GalNAc-beta1-4GlcNAc-beta1-3Man-beta1-4Glc-beta1-1Cer) the product of alpha4GT1 and alpha4GT2; the interaction regulates endocytosis and subcellular localization (PubMed:20176925). Involved in several developmental processes, including of the wings and the tracheal system (PubMed:1840519, PubMed:2125287)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LIS1;Q8MQN5;Q9VB65", "ec_number_list": "", "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016324 apical plasma membrane;GO:0030673 axolemma", "go_biological_process": "GO:0046331 lateral inhibition;GO:0048749 compound eye development;GO:0007219 Notch signaling pathway;GO:0014009 glial cell proliferation;GO:0007435 salivary gland morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P18168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18459-1", "uniprot_id": "TY3H_DROME", "mass": 65996.0, "length": 579, "protein_name": "Tyrosine 3-monooxygenase", "gene_name": "ple", "organism": "Fruit fly", "refseq_name": "pale, isoform C", "refseq_ac": "NP_001286955", "gene_names_uniprotkb": "ple; CG10118; TH", "gene_names_refseq": "CG10118; DH65B; DTH; Dmel\\CG10118; Pale; Ple; TH; Th; TyrH; VII; dTH1; dTH65B; pale/ple; ple; th", "protein_names_uniprotkb": "Tyrosine 3-monooxygenase; 1.14.16.2; Protein Pale; TH; Tyrosine 3-hydroxylase", "protein_names_refseq": "CG10118-PC; Tyrosine-3-hydroxylase; XBB70 group VII; drosophila tyrosine hydroxylase; pale, isoform C; pale; ple-PC; tyrosine 3-monooxygenase; tyrosine hydrodroxylase; tyrosine-hydroxylase; tyrosone hydroxylase", "tax_id": 7227, "disease": "autosomal recessive Segawa syndrome (Disease Ontology:DOID:0051059); withdrawal disorder (Disease Ontology:DOID:0060001); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700); Parkinson's disease (Disease Ontology:DOID:14330); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); middle cerebral artery infarction (Disease Ontology:DOID:3525); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (dme:Dmel_CG10118); (R-DME-209905)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18003740;2483109", "class_list": "", "function": "Plays an important role in the physiology of adrenergic neurons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24000;Q8SY95", "ec_number_list": "1.14.16.2", "go_molecular_function": "GO:0005506 iron ion binding;GO:0004511 tyrosine 3-monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043204 perikaryon;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008049 male courtship behavior;GO:0006585 dopamine biosynthetic process from tyrosine;GO:0007617 mating behavior;GO:0008344 adult locomotory behavior;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18459-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18487-1", "uniprot_id": "A37C_DROME", "mass": 56202.0, "length": 504, "protein_name": "Protein anon-37Cs", "gene_name": "anon-37Cs", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_476608", "gene_names_uniprotkb": "anon-37Cs; CG10561; cs; l(2)37Cs", "gene_names_refseq": "Anon-37Cs; C2; CG10561; Cs; Dmel\\CG10561; ORF1; ORF2; ORF3; TU37C1; TU37C2; TuC1; anon-37Cb; anon-37Cc; anon-37Cd; anon-37Cs; cs; l(2)37Cs", "protein_names_uniprotkb": "Protein anon-37Cs", "protein_names_refseq": "CG10561-PA; lethal(2)37Cs; transcription unit 37C2; transcription unit No. 2; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10561); (R-DME-141334); (R-DME-351200)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10231575;10731132;12537569;12537572;2874495;3007242;3478553", "class_list": "", "function": "Has a non-vital function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18376;O18377;O18378;O96568;Q95TY1;Q9VIZ7", "ec_number_list": "", "go_molecular_function": "GO:0046592 polyamine oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18487-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18491-1", "uniprot_id": "EMC_DROME", "mass": 21978.0, "length": 199, "protein_name": "Protein extra-macrochaetae", "gene_name": "emc", "organism": "Fruit fly", "refseq_name": "extra macrochaetae", "refseq_ac": "NP_523876", "gene_names_uniprotkb": "emc; CG1007", "gene_names_refseq": "0094/26; 0203/10; 0587/01; 0977/09; Ach; CG1007; Dm0688; Dmel\\CG1007; Emc; bHLHb28; emc; gov; l(3)04322; l(3)05592; l(3)61Da; l(3)j4E11; ms(3)61CD", "protein_names_uniprotkb": "Protein extra-macrochaetae", "protein_names_refseq": "CG1007-PA; achetous; emc-PA; extra macroachaetae; extra macrochaetae; extra macrochaete; extra macrocheatae; extramachrochaetae; extramacrochaetae; extramacrochaete; extramacrocheatae; extramacrocheate; golovan; male sterile(3)61CD", "tax_id": 7227, "disease": "osteoporosis (Disease Ontology:DOID:11476); Sjogren's syndrome (Disease Ontology:DOID:12894); cholestasis (Disease Ontology:DOID:13580); primary pulmonary hypertension (Disease Ontology:DOID:14557); glaucoma (Disease Ontology:DOID:1686); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dme:Dmel_CG1007); (R-DME-2559585)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;1690604;1690605", "class_list": "", "function": "Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0N0", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007530 sex determination;GO:0061525 hindgut development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18930-1", "uniprot_id": "NU3M_DROME", "mass": 13564.0, "length": 117, "protein_name": "NADH-ubiquinone oxidoreductase chain 3", "gene_name": "mt:ND3", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase subunit 3", "refseq_ac": "YP_009047272", "gene_names_uniprotkb": "mt:ND3; ND3", "gene_names_refseq": "ND3; mt:ND3", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 3; 7.1.1.2; NADH dehydrogenase subunit 3", "protein_names_refseq": "NADH dehydrogenase subunit 3", "tax_id": 7227, "disease": "Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (dme:Dmel_CG34076); (R-DME-5419276); (R-DME-611105); (R-DME-6799198)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10903372;11298822;3130291;6304652;8825764", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7HM99", "ec_number_list": "7.1.1.9;7.1.1.2;2.1.1.320;3.1.1.29;1.-.-.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18930-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18931-1", "uniprot_id": "NU4M_DROME", "mass": 51448.0, "length": 446, "protein_name": "NADH-ubiquinone oxidoreductase chain 4", "gene_name": "mt:ND4", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase subunit 4", "refseq_ac": "YP_009047274", "gene_names_uniprotkb": "mt:ND4; CG34085; ND4", "gene_names_refseq": "ND4; mt:ND4", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 4; 7.1.1.2; NADH dehydrogenase subunit 4", "protein_names_refseq": "NADH dehydrogenase subunit 4", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); macular degeneration (Disease Ontology:DOID:4448); schizophrenia (Disease Ontology:DOID:5419); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (dme:Dmel_CG34085); (R-DME-5419276); (R-DME-611105); (R-DME-6799198)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "3130291;8825764", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A075E721", "ec_number_list": "7.1.1.9;7.1.1.2;2.1.1.320;3.1.1.29;1.-.-.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0009060 aerobic respiration;GO:0015990 electron transport coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18932-1", "uniprot_id": "NU5M_DROME", "mass": 65145.0, "length": 572, "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "mt:ND5", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase subunit 5", "refseq_ac": "YP_009047273", "gene_names_uniprotkb": "mt:ND5; NADH5; ND5", "gene_names_refseq": "ND5; mt:ND5", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 5; 7.1.1.2; NADH dehydrogenase subunit 5", "protein_names_refseq": "NADH dehydrogenase subunit 5", "tax_id": 7227, "disease": "Leigh disease (Disease Ontology:DOID:3652); MELAS syndrome (Disease Ontology:DOID:3687); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (dme:Dmel_CG34083); (R-DME-5419276); (R-DME-611105); (R-DME-6799198)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10903372;11298822;3130291;7851771;8825764", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q36735;Q9MGN9;Q9MJC7", "ec_number_list": "7.1.1.9;7.1.1.2;2.1.1.320;3.1.1.29;1.-.-.-", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0015990 electron transport coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18932-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18934-1", "uniprot_id": "NU4LM_DROME", "mass": 11359.0, "length": 96, "protein_name": "NADH-ubiquinone oxidoreductase chain 4L", "gene_name": "mt:ND4L", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase subunit 4L", "refseq_ac": "YP_009047275", "gene_names_uniprotkb": "mt:ND4L; ND4L", "gene_names_refseq": "ND4L; mt:ND4L", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 4L; 7.1.1.2; NADH dehydrogenase subunit 4L", "protein_names_refseq": "NADH dehydrogenase subunit 4L", "tax_id": 7227, "disease": "Leber hereditary optic neuropathy (Disease Ontology:DOID:705); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dme:Dmel_CG34086); (R-DME-5419276)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10903372;11298822;3130291;8825764", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7HM98", "ec_number_list": "7.1.1.9;7.1.1.2;3.1.1.29", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18934-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18935-1", "uniprot_id": "CYB_DROME", "mass": 43119.0, "length": 378, "protein_name": "Cytochrome b", "gene_name": "mt:Cyt-b", "organism": "Fruit fly", "refseq_name": "cytochrome b", "refseq_ac": "YP_009047277", "gene_names_uniprotkb": "mt:Cyt-b; Cob; cytb", "gene_names_refseq": "CYTB; mt:Cyt-b", "protein_names_uniprotkb": "Cytochrome b; Complex III subunit 3; Complex III subunit III; Cytochrome b-c1 complex subunit 3; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit", "protein_names_refseq": "cytochrome b", "tax_id": 7227, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); ovarian carcinoma (Disease Ontology:DOID:4001); thyrotoxicosis (Disease Ontology:DOID:7997); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG34090); (R-DME-5419276); (R-DME-611105); (R-DME-9865881)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11298822;18727704;19540318;22851652;22863313;3130291;8825764", "class_list": "", "function": "Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ME01", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20351-1", "uniprot_id": "T23O_DROME", "mass": 44421.0, "length": 379, "protein_name": "Tryptophan 2,3-dioxygenase", "gene_name": "v", "organism": "Fruit fly", "refseq_name": "vermilion", "refseq_ac": "NP_511113", "gene_names_uniprotkb": "v; CG5163", "gene_names_refseq": "152559_at; CG2155; Crk; DmTDO; Dmel\\CG2155; Lhr; NP_511113; PDFR; PKA-RII; TDO; VASA; Ver; dYARS; mle; rhoA; sda; ver; vm; v", "protein_names_uniprotkb": "Tryptophan 2,3-dioxygenase; 1.13.11.11; Protein vermilion; TDO; TO; TRPO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; Tryptophan pyrrolase; Tryptophanase", "protein_names_refseq": "CG2155-PA; lethal hybrid rescue; sick; tryptophan 2,3-dioxygenase; v-PA; vermilion; vermillion", "tax_id": 7227, "disease": "familial hypertryptophanemia (Disease Ontology:DOID:0111703); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dme:Dmel_CG2155); (R-DME-71240)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;2108317;21636279;23333332", "class_list": "", "function": "Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety (PubMed:23333332). Required during larval growth to control the level of potentially harmful free tryptophan in the hemolymph. In the adult the same reaction is the first step in the ommochrome biosynthetic pathway (PubMed:2108317)., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VZ50", "ec_number_list": "1.13.11.11", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0051289 protein homotetramerization;GO:0070189 kynurenine metabolic process;GO:0019442 L-tryptophan catabolic process to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P20351-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21525-5", "uniprot_id": "FOSLA_DROME", "mass": 80579.0, "length": 755, "protein_name": "Transcription factor kayak, isoforms A/B/F", "gene_name": "kay", "organism": "Fruit fly", "refseq_name": "kayak, isoform F", "refseq_ac": "NP_001027577", "gene_names_uniprotkb": "kay; CG15509; Fra", "gene_names_refseq": "AP-1; AP1; Ap1; CG15507; CG15509; CG33956; D-Fos; D-fos/kay; D-fos; DFOS; DFos; DFra; DM30; DM3; Dfos; Dmel\\CG33956; FOS; Fos; Fra; KAY; Kay; c-Fos; c-fos; d-Fos; d-fos; dAP-1; dFRA; dFos; dFra; dfos; dlhD; fbz; fos; fra; kay", "protein_names_uniprotkb": "Transcription factor kayak, isoforms A/B/F; AP-1; Dfos; Fos-related antigen; dFra", "protein_names_refseq": "CG33956-PF; Dfos/kayak; Fos-related antigen; Fos; activator protein 1; dorsal holes D; kay-PF; kayak, isoform F", "tax_id": 7227, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); congenital hypothyroidism (Disease Ontology:DOID:0050328); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ductal carcinoma in situ (Disease Ontology:DOID:0060074); sleeping sickness (Disease Ontology:DOID:10112); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); hypospadias (Disease Ontology:DOID:10892); functional diarrhea (Disease Ontology:DOID:11371); Pick's disease (Disease Ontology:DOID:11870); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); rectal benign neoplasm (Disease Ontology:DOID:1984); colon adenocarcinoma (Disease Ontology:DOID:234); Wernicke encephalopathy (Disease Ontology:DOID:2384); morphine dependence (Disease Ontology:DOID:2560); glomerulonephritis (Disease Ontology:DOID:2921); temporal lobe epilepsy (Disease Ontology:DOID:3328); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); renal carcinoma (Disease Ontology:DOID:4451); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); migraine (Disease Ontology:DOID:6364); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); degenerative disc disease (Disease Ontology:DOID:90); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); acute myocardial infarction (Disease Ontology:DOID:9408); irritable bowel syndrome (Disease Ontology:DOID:9778); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG33956); (R-DME-209394); (R-DME-209409); (R-DME-209425); (R-DME-2559580); (R-DME-2871796); (R-DME-450341)", "pathway_count": 7, "publication_count": 21, "publication_id_list": "10028968;10409696;10572048;10731132;10903185;11269501;11470538;11865058;12537569;12537572;12732719;15640802;1749429;17803358;18327897;18571877;1922387;2116361;7816143;8946915;8946916", "class_list": "", "function": "Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8MPI0;Q400M6;Q400M7;Q53YJ8;Q8T9E2;Q9BH37;Q9NBW7;Q9VAH5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0048749 compound eye development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P21525-5", "record_type": "protein" }, { "uniprot_canonical_ac": "P22745-1", "uniprot_id": "BAM_DROME", "mass": 50275.0, "length": 442, "protein_name": "Protein bag of marbles", "gene_name": "bam", "organism": "Fruit fly", "refseq_name": "bag of marbles", "refseq_ac": "NP_476800", "gene_names_uniprotkb": "bam; CG10422", "gene_names_refseq": "BAM; Bam-C; BamC; BamF; Bam; CG10422; Dmel\\CG10422; alpha; bam; fs(3)neo61; ham", "protein_names_uniprotkb": "Protein bag of marbles", "protein_names_refseq": "CG10422-PA; bag of marbles; bag of marble; bag-of-marbles; bam-PA; transcript alpha", "tax_id": 7227, "disease": "germ cell cancer (Disease Ontology:DOID:2994)", "pathway": " (dme:Dmel_CG10422)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537569;12537572;16357040;19470484;19556547;20018708;2279698;23122292;23526974;25412508;28190776;28484036;30879902;9334284", "class_list": "", "function": "Regulatory component of a deubiquitinase complex consisting of bam and otu (PubMed:28484036). The complex deubiquitinates K63-linked polyubiquitinated proteins, antagonizing the ubiquitination activity of Traf6 and regulating the IMD immune signaling pathway (PubMed:30879902). Otu-bam deubiquitinase activity is regulated by Traf6 dependent immune signaling regulation of bam expression levels; this forms a feedback loop that regulates the IMD immune signaling pathway and balances gut immune activity during aging (PubMed:30879902). The complex deubiquitinates and stabilizes CycA/cyclin-A to regulate CycA-dependent differentiation (PubMed:28484036). Required to initiate both male and female gametogenesis (PubMed:2279698). Part of a complex with bgcn involved in 3'-UTR-dependent translational repression of a subset of mRNAs, including those for mei-P26, nanos and shg/E-cadherin (PubMed:19470484, PubMed:19556547, PubMed:23122292). Repression of mei-P26 is targeted by let-7 miRNA (PubMed:23122292). Involved in a regulatory cascade with mei-P26 to control the progression of cystocytes through transit amplification and the switch to spermatocyte differentiation; mei-P26 facilitates bam accumulation, which in turn represses translation of mei-P26 (PubMed:19470484, PubMed:20018708, PubMed:2279698, PubMed:23122292, PubMed:28484036, PubMed:9334284). Forms a complex with tut and bgcn involved in 3'-UTR-dependent post-transcriptional repression of several 3'-RNA processing factors, which promotes germline stem cell lineage differentiation and mitosis-to-meiosis transition (PubMed:25412508, PubMed:28190776)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2PNQ8;Q2PNQ9;Q2PNR5;Q2PNR8;Q2PNR9;Q2PNS3;Q2PNS6;Q2PNS8;Q2PNT1;Q8MRX8;Q9VBV0", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003730 mRNA 3'-UTR binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045170 spectrosome;GO:0045169 fusome", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:1903006 positive regulation of protein K63-linked deubiquitination;GO:0007283 spermatogenesis;GO:0017148 negative regulation of translation;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P22745-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23128-1", "uniprot_id": "DDX6_DROME", "mass": 51945.0, "length": 459, "protein_name": "ATP-dependent RNA helicase me31b", "gene_name": "me31B", "organism": "Fruit fly", "refseq_name": "maternal expression at 31B, isoform A", "refseq_ac": "NP_523533", "gene_names_uniprotkb": "me31B; CG4916", "gene_names_refseq": "CG4916; DDX6; Dhh1p/Me31b; DmRH3; Dmel\\CG4916; ME31B; Mat31B; Me31B; Me31b; l(2)k06607; me31B; me31b", "protein_names_uniprotkb": "ATP-dependent RNA helicase me31b; 3.6.4.13; Maternal expression at 31B", "protein_names_refseq": "CG4916-PA; maternal expression at 31B, isoform A; maternal expression at 31B; me31B-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4916); (R-DME-430039)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10662770;10731132;11546740;12537569;12537572;16256742;17178403;17982591;18327897;18590813;18765641;1900936;19285948;20452345;21081899;21267420;21447556;28388438;28875934;28945271;31114929;31439631", "class_list": "", "function": "ATP-dependent RNA helicase which is a core component of a variety of ribonucleoprotein complexes (RNPs) that play critical roles in translational repression and mRNA decapping during embryogenesis, oogenesis, neurogenesis and neurotransmission (PubMed:11546740, PubMed:16256742, PubMed:17178403, PubMed:17982591, PubMed:18590813, PubMed:21267420, PubMed:21447556, PubMed:28388438, PubMed:28875934, PubMed:31114929). Recruits core components and translational repressors to some RNP complexes, and mediates RNP aggregation into processing granules such as P-bodies (PubMed:11546740, PubMed:16256742, PubMed:17178403, PubMed:17982591, PubMed:21267420, PubMed:21447556, PubMed:28875934). As part of a RNP complex containing tral, eIF4E1, cup, and pAbp, involved in RNP-mediated translational repression of maternal mRNAs during oogenesis and embryogenesis (PubMed:28875934). As part of a RNP complex containing tral and the RNA localization factors exu and yps, mediates translational silencing of mRNAs such as osk/oskar and bcd/bicoid during their transport to the oocyte in order to prevent their translation until they reach their positional destinations (PubMed:11546740). In neurons and possibly imaginal disks, involved in miRNA-mediated translational repression, possibly in association with components of the piRNA transposon silencing pathway (PubMed:17178403, PubMed:17982591, PubMed:21081899, PubMed:21267420, PubMed:21447556). Involved in RNA localization and protein trafficking in the oocyte (PubMed:11546740, PubMed:16256742). As part of an ER-associated RNP containing tral, cup and yps, required for tral-dependent ER exit site formation and consequently efficient trafficking of proteins such as grk and yl through the secretory pathway (PubMed:16256742). Component of neuron RNPs that mediate transport and translation of neuronal RNAs, including translation repression of synaptic transcripts in preparation for their dendritic targeting (PubMed:17178403, PubMed:21267420, PubMed:28388438). As part of the Atx2-Not1 repressor complex promotes Not1-dependent post-transcriptional gene silencing in adult circadian pacemaker neurons in order to sustain high-amplitude circadian rhythms and Pdf cycling in a per-independent manner (PubMed:28388438). Promotes the interaction between Atx2 and Not1 within the Atx2-Not1 RNP complex (PubMed:28388438). Recruited to the 4EHP-GYF2 complex by Gyf, where it plays a role in 4EHP-GYF2 mediated translational repression and mRNA decay (PubMed:31114929)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IPC9;Q961D2;Q9VL17", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0098794 postsynapse;GO:0000932 P-body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0046959 habituation;GO:0017148 negative regulation of translation;GO:0035278 miRNA-mediated gene silencing by inhibition of translation;GO:0035195 miRNA-mediated post-transcriptional gene silencing", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P23128-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23257-1", "uniprot_id": "TBG1_DROME", "mass": 53339.0, "length": 475, "protein_name": "Tubulin gamma-1 chain", "gene_name": "gammaTub23C", "organism": "Fruit fly", "refseq_name": "gamma-Tubulin at 23C", "refseq_ac": "NP_476804", "gene_names_uniprotkb": "gammaTub23C; CG3157; Tub23C; TubG1; TubG23C; TubG", "gene_names_refseq": "CG 3157; CG3157; D.m.GAMMA-23C; Dmel\\CG3157; GAMMA23C; GTU88*; GTUB; Tub23C; Tub23; Tub3A; g-Tubulin; gTub23C; gTub; gamma tubulin; gamma-Tub23C; gamma-Tub; gamma-tub 23C; gamma-tub23C; gamma-tub23; gamma-tubulin; gamma-tub; gammaTUB23C; gammaTUB; gammaTub23CD; gammaTub23C; gammaTub23c; gammaTub; gamma[zy]; gammatub23C; gammatubulin; gammatub; l(2)23Ce; tubulin", "protein_names_uniprotkb": "Tubulin gamma-1 chain; Gamma-1-tubulin", "protein_names_refseq": "23C gamma-tubulin; 23C-gamma-tubulin; CG3157-PA; gama-tubulin; gamma tubulin 23C; gamma tubulin; gamma-Tubulin at 23C; gamma-Tubulin; gamma-tubulin (23C); gamma-tubulin 23C; gamma-tubulin(23C); gamma-tubulin-1; gamma-tubulin23C; gammaTub23C-PA; gammatubulin; lethal (2) 23Ce", "tax_id": 7227, "disease": "muscular disease (Disease Ontology:DOID:0080000); complex cortical dysplasia with other brain malformations 4 (Disease Ontology:DOID:0090138); inclusion body myositis (Disease Ontology:DOID:3429)", "pathway": " (dme:Dmel_CG3157)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;1904010;22751930;32066907", "class_list": "", "function": "Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VQJ5", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0019001 guanyl nucleotide binding;GO:0140490 microtubule nucleator activity", "go_cellular_component": "GO:0008275 gamma-tubulin small complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007283 spermatogenesis;GO:0051306 mitotic sister chromatid separation;GO:0007020 microtubule nucleation;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23257-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23380-1", "uniprot_id": "VATL_DROME", "mass": 16267.0, "length": 159, "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "Vha16-1", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase 16kD subunit 1, isoform A", "refseq_ac": "NP_476801", "gene_names_uniprotkb": "Vha16-1; CG3161; VHA; Vha16", "gene_names_refseq": "ATP6V0C; BcDNA:SD02875; CG3161; Dmel\\CG3161; DucC; EP2372; MRE15; V-ATPase; Vha16-1; Vha16; Vha1; Vhac; v-ATPase; vha16-1; vha16", "protein_names_uniprotkb": "V-type proton ATPase 16 kDa proteolipid subunit c; Ductin; V-ATPase 16 kDa proteolipid subunit c; VHA16K; Vacuolar H+ ATPase subunit 16-1; Vacuolar proton pump 16 kDa proteolipid subunit c", "protein_names_refseq": "CG3161-PA; Vha16-1-PA; ductin subunit C; ductin, vacuolar H(+)-ATPase subunit C proteolipid; ductin; mRNA-like ncRNA in embryogenesis 15; vacuolar H[+] ATPase 16kD subunit 1, isoform A; vacuolar H[+] ATPase 16kD subunit; vacuolar H[+] ATPase subunit 16-1; vacuolar H[+]-ATPase c subunit", "tax_id": 7227, "disease": "early-onset epilepsy 3 (Disease Ontology:DOID:0070472); intellectual disability (Disease Ontology:DOID:1059); epilepsy (Disease Ontology:DOID:1826); thyroid gland carcinoma (Disease Ontology:DOID:3963)", "pathway": " (dme:Dmel_CG3161); (R-DME-1222556); (R-DME-6798695); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10731132;12537572;2147478;32269334;7983150", "class_list": "", "function": "Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32269334). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZ55;Q0E9N6;Q53XD4;Q9V9D2", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0016020 membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex;GO:0045169 fusome", "go_biological_process": "GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P23380-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23625-1", "uniprot_id": "GNAQ_DROME", "mass": 41295.0, "length": 353, "protein_name": "G protein alpha q subunit", "gene_name": "Galphaq", "organism": "Fruit fly", "refseq_name": "G protein alpha subunit q, isoform A", "refseq_ac": "NP_725191", "gene_names_uniprotkb": "Galphaq; CG17759; Galpha49b; Galpha; Gqalpha; Gq; dGqalpha; dgq", "gene_names_refseq": "CG17759; DGalpha[[q]]; DGalphaq; DGqalpha; DGq; Dgq; DmGalpha[[q]]; Dmel\\CG17759; Dromel_CG17759_galpha49b_mORF; G alpha 49B; G?q; GNAQ/11/14; G[[a]]q; G[[alphaq]]; G[[q]]alpha; G[[q]]; G[[qalpha]]; G[q]; Galpha49B; Galpha49b; Galpha[[q]]; Galphaq; Galpha; Gaq; Gqa-3; Gqalpha[[e]]; Gqalphae; Gqalpha{e}; Gqalpha; Gq; dG[[alphaq]]; dG[[q]]alpha; dGaalpha; dGqa-49b; dGqalpha-3; dGqalpha-49b; dGqalpha; dGq; dgqalpha; dgq; galpha49B; sast", "protein_names_uniprotkb": "G protein alpha q subunit; Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding protein alpha-q; dGQalpha", "protein_names_refseq": "CG17759-PA; G protein 49B; G protein alpha q subunit; G protein alpha subunit q, isoform A; G protein alpha49B; G-protein alpha subunit; G-protein alpha49B; G-protein-alpha[[q]]; Galphaq-PA; small amplify and slow termination", "tax_id": 7227, "disease": "familial hypocalciuric hypercalcemia 2 (Disease Ontology:DOID:0060701); autosomal dominant hypocalcemia 2 (Disease Ontology:DOID:0090108); familial multiple nevi flammei (Disease Ontology:DOID:0111529); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung non-small cell carcinoma (Disease Ontology:DOID:3908); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG17759); (R-DME-112043); (R-DME-202040); (R-DME-416476); (R-DME-418592); (R-DME-428930); (R-DME-9856530); (R-DME-9860927)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "10608815;10731132;12537569;12537572;2125225;8524786", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZE6;P54400;Q29QX1;Q540Y7;Q9I7C8;Q9V6E2", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0005834 heterotrimeric G-protein complex;GO:0016028 rhabdomere", "go_biological_process": "GO:0030322 stabilization of membrane potential;GO:0016199 axon midline choice point recognition;GO:0070050 neuron cellular homeostasis;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23625-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23792-1", "uniprot_id": "DISC_DROME", "mass": 62369.0, "length": 568, "protein_name": "Protein disconnected", "gene_name": "disco", "organism": "Fruit fly", "refseq_name": "disconnected, isoform B", "refseq_ac": "NP_001033847", "gene_names_uniprotkb": "disco; CG9908", "gene_names_refseq": "CG9908; DISCO; Disco; Dmel\\CG9908; disco; disc", "protein_names_uniprotkb": "Protein disconnected", "protein_names_refseq": "CG9908-PB; disco-PB; disconnected, isoform B; disconnected", "tax_id": 7227, "disease": "primary ovarian insufficiency 16 (Disease Ontology:DOID:0080873)", "pathway": " (dme:Dmel_CG9908)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;1901262;1901263", "class_list": "", "function": "Required for the establishment of stable connections between the larval optic nerves, the Bolwig's nerves, and their target cells in the brain during embryonic development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YG0;Q9VXJ4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007420 brain development;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23792-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24492-1", "uniprot_id": "DIPA_DROME", "mass": 11314.0, "length": 106, "protein_name": "Diptericin A", "gene_name": "DptA", "organism": "Fruit fly", "refseq_name": "diptericin A", "refseq_ac": "NP_476808", "gene_names_uniprotkb": "DptA; CG12763; Dipt; Dpt", "gene_names_refseq": "143443_at; CG12763; DIM 27; DIPT; DPT; Dep; DipA; Dipt A; DiptA; Diptericin; Dipt; Dip; Dit; Dmel\\CG12763; DptA; Dpt; DtpA; diptA; diptericin; dipt; dip; dpt A; dptA; dpt", "protein_names_uniprotkb": "Diptericin A", "protein_names_refseq": "CG12763-PA; Diptericin-A; DiptericinA; DptA-PA; diptercin; diptericin (A); diptericin A; diptericin precursor; diptericine; diptericin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12763)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;11269502;12537569;12537572;1373375;2125051;31350199;9335607", "class_list": "", "function": "Antimicrobial peptide required to resist Gram-negative bacterial infections, regulated by Dredd., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O16838;O16839;O16840;O16841;O18669;Q9V8P5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0009617 response to bacterium;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P24492-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25158-1", "uniprot_id": "OSKA_DROME", "mass": 69284.0, "length": 606, "protein_name": "Maternal effect protein oskar", "gene_name": "osk", "organism": "Fruit fly", "refseq_name": "oskar, isoform A", "refseq_ac": "NP_731295", "gene_names_uniprotkb": "osk; CG10901", "gene_names_refseq": "CG10901; Dm-osk; Dmel\\CG10901; OSK; Oskar; Osk; norka; osk", "protein_names_uniprotkb": "Maternal effect protein oskar", "protein_names_refseq": "CG10901-PA; dmoskar; osk-PA; oskar, isoform A; oskar", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10901)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10488336;10731132;11546740;12537569;12537572;1641021;18327897;2070416;2070417;33891588", "class_list": "", "function": "Organizes the germ plasm and directs localization of the posterior determinant nanos. Oskar protein is required to keep nanos (nos) RNA and staufen protein at the posterior pole., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q59DY0;Q95TT0;Q9V3P1", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005938 cell cortex;GO:0043186 P granule;GO:0043073 germ cell nucleus", "go_biological_process": "GO:0030719 P granule organization;GO:0008542 visual learning;GO:0043488 regulation of mRNA stability;GO:0035282 segmentation;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P25158-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25160-1", "uniprot_id": "ARL1_DROME", "mass": 20247.0, "length": 180, "protein_name": "ADP-ribosylation factor-like protein 1", "gene_name": "Arl1", "organism": "Fruit fly", "refseq_name": "ADP ribosylation factor-like 1", "refseq_ac": "NP_524098", "gene_names_uniprotkb": "Arl1; Arf72A; CG6025; arl", "gene_names_refseq": "72CDd; ARL1_DROME; ARL1; Arf72A; Arf; Arl1; BcDNA:GM20805; CG 6025; CG6025; Dmel\\CG6025; P25160; arf72A; arf[72A]; arl1; arl; dARL1p; dArl1; l(3)72Ae; l(3)72CDd", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 1", "protein_names_refseq": "ADP ribosylation factor-like 1; Arf-like 1; Arf72A; Arl1-PA; CG6025-PA; arflike at 72A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6025); (R-DME-6811440)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;1901655", "class_list": "", "function": "GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUW7", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005802 trans-Golgi network;GO:0098793 presynapse", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0090158 endoplasmic reticulum membrane organization;GO:0006886 intracellular protein transport;GO:0030334 regulation of cell migration;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25160-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25167-1", "uniprot_id": "RPC2_DROME", "mass": 128515.0, "length": 1137, "protein_name": "DNA-directed RNA polymerase III subunit RPC2", "gene_name": "Polr3B", "organism": "Fruit fly", "refseq_name": "RNA polymerase III subunit B", "refseq_ac": "NP_523706", "gene_names_uniprotkb": "Polr3B; CG8344; RPC2; Rp128; RpIII128", "gene_names_refseq": "C128; CG8344; DmRP128; Dmel\\CG8344; Polr3B; RET1; RP128; RpIII128", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC2; 2.7.7.6; C128; DNA-directed RNA polymerase III 128 kDa polypeptide; DNA-directed RNA polymerase III subunit B; RNA polymerase III subunit C2", "protein_names_refseq": "CG8344-PA; Polr3B-PA; RNA polymerase III 128kD subunit; RNA polymerase III subunit B; RNA polymerase IIIb; RNA polymerase III", "tax_id": 7227, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 8 (Disease Ontology:DOID:0060797); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (dme:Dmel_CG8344); (R-DME-76061); (R-DME-76066)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;1910149", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and Polr3B is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRD5;Q9V649", "ec_number_list": "2.7.7.6", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0032549 ribonucleoside binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter;GO:0006354 DNA-templated transcription elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25991-1", "uniprot_id": "SUF_DROME", "mass": 88214.0, "length": 765, "protein_name": "Protein suppressor of forked", "gene_name": "su(f)", "organism": "Fruit fly", "refseq_name": "suppressor of forked, isoform F", "refseq_ac": "NP_001015241", "gene_names_uniprotkb": "su(f); CG17170", "gene_names_refseq": "19; 28; 29; 3-DES; 3DES; CG17170; CstF-77; CstF77; Cstf77; Dmel\\CG17170; EC235; R-9-18; R9-18; SU-f; Su(f); l(1)20Eb; l(1)3DES; l(1)EC235; l(1)G0393; l(1)R-9-18; l(1)X1; l(1)X3; l(1)su(f); l3DES; su(f); su-f; su[+]-f", "protein_names_uniprotkb": "Protein suppressor of forked", "protein_names_refseq": "CG17170-PF; lethal3Des; section 19; section 28; section 29; su(f)-PF; suppressor of forked, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17170); (R-DME-73856); (R-DME-77595); (R-DME-9770562)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;8436295", "class_list": "", "function": "Essential protein, may play a role in mRNA production or stability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A023GQK0;A8Y5B4;A8Y5B5;Q24539;Q5BI40;Q6NKM3;Q7PLW9;Q7PLX0;Q7PLX1;Q8MZI2;Q9W5P7", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005848 mRNA cleavage stimulating factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25991-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26017-1", "uniprot_id": "PC_DROME", "mass": 43976.0, "length": 390, "protein_name": "Polycomb group protein Pc", "gene_name": "Pc", "organism": "Fruit fly", "refseq_name": "polycomb", "refseq_ac": "NP_524199", "gene_names_uniprotkb": "Pc; CG7618", "gene_names_refseq": "CG32443; CG7618; DmPc; Dmel\\CG32443; PC; Pc-G; PcG; Pc; dPC; pc", "protein_names_uniprotkb": "Polycomb group protein Pc; Protein polycomb", "protein_names_refseq": "CG32443-PA; Pc-PA; polycomb", "tax_id": 7227, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); anaplastic thyroid carcinoma (Disease Ontology:DOID:0080522); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); clear cell adenocarcinoma (Disease Ontology:DOID:4468); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); myeloid leukemia (Disease Ontology:DOID:8692); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (dme:Dmel_CG32443); (R-DME-2559580); (R-DME-3108214); (R-DME-3899300); (R-DME-4570464); (R-DME-8939243); (R-DME-8943724)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10731132;11493925;11583617;12537572;1898775;22354997;27326929;30078725", "class_list": "", "function": "Polycomb group (PcG) protein (PubMed:1898775). PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (PubMed:11493925, PubMed:11583617, PubMed:1898775). PcG proteins are not required to initiate repression, but to maintain it during later stages of development (PubMed:1898775). Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility (PubMed:11493925, PubMed:11583617). Promotes locus-specific chromatin compaction (PubMed:11493925, PubMed:11583617). Binds to (N(6)-methyladenosine) DNA and thereby might implement repression of specific loci (PubMed:30078725)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VP49", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0043565 sequence-specific DNA binding;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0035102 PRC1 complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:2001229 negative regulation of response to gamma radiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0016322 neuron remodeling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P26017-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26023-1", "uniprot_id": "PIG1_DROME", "mass": 18504.0, "length": 172, "protein_name": "Pre-intermoult gene 1 protein", "gene_name": "Pig1", "organism": "Fruit fly", "refseq_name": "Pre-intermoult gene 1", "refseq_ac": "NP_476677", "gene_names_uniprotkb": "Pig1; CG10790; Pig-1; gsg", "gene_names_refseq": "CG10790; Dmel\\CG10790; EG:96G10.1; Pig-1; Pig1; gsg; pig1", "protein_names_uniprotkb": "Pre-intermoult gene 1 protein; Gland-specific protein", "protein_names_refseq": "CG10790-PB; Pig1-PB; Pre-intermolt gene 1; Pre-intermoult gene 1; gland specific gene", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10790)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10731137;12537569;12537572;1769273;3125018", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9QP90;O76914;Q24519;Q3Y420;Q95SA5;Q9W4T3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P26023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26686-2", "uniprot_id": "SRR55_DROME", "mass": 39782.0, "length": 350, "protein_name": "Serine-arginine protein 55", "gene_name": "B52", "organism": "Fruit fly", "refseq_name": "B52, isoform O", "refseq_ac": "NP_001014619", "gene_names_uniprotkb": "B52; CG10851; E(Dfd); RS55; SR55", "gene_names_refseq": "B52/SRp55; B52/dSRp55; B52; CG10851; Dmel\\CG10851; E(Dfd); E726; MabB52; RRM8; RSp55; Rbp8; SR55; SRSF6; SRp55; dSRp55; l(3)s2249; rrm8", "protein_names_uniprotkb": "Serine-arginine protein 55; 52 kDa bracketing protein; Protein B52; Protein enhancer of deformed; SRP55", "protein_names_refseq": "B52, isoform O; B52-PO; CG10851-PO; Monoclonal-antibody-B52; RNA-binding protein 8; Serine/arginine rich protein 55; enhancer of deformed; serine-arginine protein 55; splicing factor B52", "tax_id": 7227, "disease": "spermatogenic failure 3 (Disease Ontology:DOID:0070168); Huntington's disease (Disease Ontology:DOID:12858); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); lung cancer (Disease Ontology:DOID:1324); Down syndrome (Disease Ontology:DOID:14250); colon adenocarcinoma (Disease Ontology:DOID:234); skin cancer (Disease Ontology:DOID:4159); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG10851)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;1717489;1741384;18327897;1885003;7935465;8417324", "class_list": "", "function": "Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2U2;E1JIK1;E1JIK2;E1JIK3;E4NKI6;Q24252;Q26277;Q8IH12;Q8ING7;Q8ING8;Q8ING9;Q8MZ66;Q8T0I0;Q9VFT0;Q9VFT1", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000791 euchromatin;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0044819 mitotic G1/S transition checkpoint signaling;GO:0000278 mitotic cell cycle;GO:0051607 defense response to virus;GO:0008380 RNA splicing;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P26686-2", "record_type": "protein" }, { "uniprot_canonical_ac": "P26802-1", "uniprot_id": "DDX51_DROME", "mass": 77590.0, "length": 687, "protein_name": "Probable ATP-dependent RNA helicase Dbp73D", "gene_name": "Dbp73D", "organism": "Fruit fly", "refseq_name": "dead box protein 73D", "refseq_ac": "NP_476833", "gene_names_uniprotkb": "Dbp73D; CG9680", "gene_names_refseq": "CG9680; DBP73D; DDX51; Dbp73D; DmRH7; Dmel\\CG9680", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase Dbp73D; 3.6.4.13; DEAD box protein 73D", "protein_names_refseq": "CG9680-PA; Dbp73D-PA; dead box protein 73D; dead box protein 73", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9680)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;1620603", "class_list": "", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9XZ18", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P26802-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27779-1", "uniprot_id": "CUP7_DROME", "mass": 13347.0, "length": 122, "protein_name": "Pupal cuticle protein Edg-78E", "gene_name": "Edg78E", "organism": "Fruit fly", "refseq_name": "Ecdysone-dependent gene 78E, isoform B", "refseq_ac": "NP_001287140", "gene_names_uniprotkb": "Edg78E; CG7673; DMLCP78; DmelEdg78E; Dmel\\CG7673; Dmel_CG7673; EDG-78E; EDG-78; EDG78E; EDG78; Edg78e; Edg78", "gene_names_refseq": "CG7673; DMLCP78; DmelEdg78E; Dmel\\CG7673; EDG-78; EDG78E; EDG78; Edg78E; Edg78e; Edg78", "protein_names_uniprotkb": "Pupal cuticle protein Edg-78E", "protein_names_refseq": "CG7673-PB; Ecdysone-dependent gene 78E, isoform B; Edg78E-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7673)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;1713868;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the cuticle of the pupa of fruit fly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VP54", "ec_number_list": "", "go_molecular_function": "GO:0008010 structural constituent of chitin-based larval cuticle;GO:0008011 structural constituent of pupal chitin-based cuticle;GO:0042302 structural constituent of cuticle", "go_cellular_component": "GO:0062129 chitin-based extracellular matrix", "go_biological_process": "GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P27779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28518-1", "uniprot_id": "XPA_DROME", "mass": 33875.0, "length": 296, "protein_name": "DNA repair protein complementing XP-A cells homolog", "gene_name": "Xpac", "organism": "Fruit fly", "refseq_name": "xeroderma pigmentosum group A-like", "refseq_ac": "NP_476866", "gene_names_uniprotkb": "Xpac; CG6358; Xpa", "gene_names_refseq": "CG6358; DhR14; DhXPA; DmXPA; Dmel\\CG6358; Dxpa; EG:EG0007.8; XPAC; XPA_DROME; XPA; Xpac; Xpa; dmXPA; dxpa", "protein_names_uniprotkb": "DNA repair protein complementing XP-A cells homolog; Xeroderma pigmentosum group A-complementing protein homolog", "protein_names_refseq": "CG6358-PA; Xpac-PA; xeroderma pigmentosum group A-like", "tax_id": 7227, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843)", "pathway": " (dme:Dmel_CG6358); (R-DME-5696395); (R-DME-5696400); (R-DME-6781823); (R-DME-6782135)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10731132;10731137;12537572;1764072;7673233", "class_list": "", "function": "Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24594;Q9V3V8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0005634 nucleus", "go_biological_process": "GO:0006284 base-excision repair;GO:0070914 UV-damage excision repair;GO:0000715 nucleotide-excision repair, DNA damage recognition;GO:0006289 nucleotide-excision repair;GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28518-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29349-4", "uniprot_id": "CSW_DROME", "mass": 103768.0, "length": 945, "protein_name": "Tyrosine-protein phosphatase corkscrew", "gene_name": "csw", "organism": "Fruit fly", "refseq_name": "corkscrew, isoform A", "refseq_ac": "NP_477130", "gene_names_uniprotkb": "csw; CG3954", "gene_names_refseq": "19-106; CG3954; CSW; Csw/Shp2; Csw; Dmel\\CG3954; E(sev)1A; EG:BACN25G24.2; SHP-2; Shp-2; Shp2/csw; anon-WO03040301.207; anon-WO03040301.209; anon-WO03040301.219; csw/SHP-2; csw; l(1)2Db; l(1)2Dd; l(1)G0170; l(1)GA114; l(1)csw", "protein_names_uniprotkb": "Tyrosine-protein phosphatase corkscrew; 3.1.3.48", "protein_names_refseq": "CG3954-PA; corkscrew, isoform A; corkscrew; csw-PA; enhancer of sevenless 1A", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); hepatocellular adenoma (Disease Ontology:DOID:0050868); idiopathic scoliosis (Disease Ontology:DOID:0060250); Noonan syndrome 1 (Disease Ontology:DOID:0060578); Noonan syndrome with multiple lentigines 1 (Disease Ontology:DOID:0080548); metachondromatosis (Disease Ontology:DOID:0111512); stomach cancer (Disease Ontology:DOID:10534); anogenital venereal wart (Disease Ontology:DOID:11168); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); Noonan syndrome with multiple lentigines (Disease Ontology:DOID:14291); glaucoma (Disease Ontology:DOID:1686); chondroma (Disease Ontology:DOID:2602); Noonan syndrome (Disease Ontology:DOID:3490); cervical cancer (Disease Ontology:DOID:4362); tetralogy of Fallot (Disease Ontology:DOID:6419); atrophic gastritis (Disease Ontology:DOID:8929)", "pathway": " (dme:Dmel_CG3954); (R-DME-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;10731137;12537569;12537572;12694293;1638629;18327897;22426252;8948575", "class_list": "", "function": "Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw. Dephosphorylates drpr isoform A which is required for the inhibition by drpr isoform A of glial cell engulfment of axonal debris produced following axonal injury (PubMed:22426252)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "L7XAI0;Q24032;Q24033;Q8I074;Q8I0H8;Q8I0S4;Q8ISD5;Q8ISD6;Q9V3H1;Q9W524", "ec_number_list": "3.2.1.17;1.1.1.42;3.5.1.28;3.2.1.14;3.1.3.16;3.1.3.48;3.5.3.1;4.1.2.13;3.1.3.-;3.1.3.2;1.16.3.1;2.7.1.35;3.1.3.27;2.3.2.5;3.4.19.9;3.4.24.-;2.7.10.2;3.6.1.5;3.5.1.3;3.3.2.6;3.5.4.5;5.4.2.2;3.4.17.13;3.2.1.-", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007418 ventral midline development;GO:0000278 mitotic cell cycle;GO:0006911 phagocytosis, engulfment;GO:0030154 cell differentiation;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P29349-4", "record_type": "protein" }, { "uniprot_canonical_ac": "P29413-1", "uniprot_id": "CALR_DROME", "mass": 46808.0, "length": 406, "protein_name": "Calreticulin", "gene_name": "Calr", "organism": "Fruit fly", "refseq_name": "calreticulin, isoform B", "refseq_ac": "NP_001262430", "gene_names_uniprotkb": "Calr; CG9429; Crc", "gene_names_refseq": "CALR; CG9429; Calr; Clr; CrT; Crc; Dmel\\CG9429; anon-EST:Liang-2.11; anon-EST:Liang-2.17; anon-EST:fe3D7; chr3R:5454619..5454778; clone 2.11; clone 2.17; crc; eth; potp", "protein_names_uniprotkb": "Calreticulin", "protein_names_refseq": "CG9429-PB; Calr-PB; anon-fast-evolving-3D7; calreticulin, isoform B; calreticulin; pot pourri; potpourri", "tax_id": 7227, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); colon carcinoma (Disease Ontology:DOID:1520); neuroendocrine tumor (Disease Ontology:DOID:169); colon cancer (Disease Ontology:DOID:219); essential thrombocythemia (Disease Ontology:DOID:2224); thrombocytosis (Disease Ontology:DOID:2228); ovarian cancer (Disease Ontology:DOID:2394); gallbladder cancer (Disease Ontology:DOID:3121); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); myelofibrosis (Disease Ontology:DOID:4971); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); Burkitt lymphoma (Disease Ontology:DOID:8584); sideroblastic anemia (Disease Ontology:DOID:8955); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dme:Dmel_CG9429); (R-DME-901042)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537572;1296819;15952742;2365822", "class_list": "", "function": "Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VHA3", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0042048 olfactory behavior;GO:0006457 protein folding;GO:0030431 sleep;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29413-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29742-1", "uniprot_id": "CLH_DROME", "mass": 191177.0, "length": 1678, "protein_name": "Clathrin heavy chain", "gene_name": "Chc", "organism": "Fruit fly", "refseq_name": "clathrin heavy chain, isoform E", "refseq_ac": "NP_001096993", "gene_names_uniprotkb": "Chc; CG9012; CHC; CLH; Cla; Clh; D-Chc; Dmel\\CG9012; Dmel_CG9012; chc1; chc; dCHC; l(1)13Fb; l(1)G0438; l(1)VI", "gene_names_refseq": "CG9012; CHC; CLH; Chc; Cla; Clh; D-Chc; Dmel\\CG9012; chc1; chc; dCHC; l(1)13Fb; l(1)G0438; l(1)VI", "protein_names_uniprotkb": "Clathrin heavy chain", "protein_names_refseq": "CG9012-PE; Chc-PE; clathrin hc; clathrin heavy chain, isoform E; clathrin heavy chain; clathrin heavy-chain", "tax_id": 7227, "disease": "autosomal dominant intellectual developmental disorder 56 (Disease Ontology:DOID:0080226)", "pathway": " (dme:Dmel_CG9012); (R-DME-177504); (R-DME-190873); (R-DME-196025); (R-DME-3928665); (R-DME-432720); (R-DME-432722); (R-DME-437239); (R-DME-5099900); (R-DME-5140745); (R-DME-8856825); (R-DME-8856828); (R-DME-8866427); (R-DME-8964038); (R-DME-9013420); (R-DME-9013424)", "pathway_count": 16, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;24786584;25589440;26109356;26109357;8375651", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540W2;Q9VXN6", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0032051 clathrin light chain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0005938 cell cortex;GO:0030141 secretory granule;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0030198 extracellular matrix organization;GO:0031623 receptor internalization;GO:0040008 regulation of growth", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P29742-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29746-1", "uniprot_id": "BNB_DROME", "mass": 45816.0, "length": 442, "protein_name": "Protein bangles and beads", "gene_name": "bnb", "organism": "Fruit fly", "refseq_name": "bangles and beads, isoform C", "refseq_ac": "NP_523406", "gene_names_uniprotkb": "bnb; CG7088", "gene_names_refseq": "Bnb; CG7088; Dmel\\CG7088; GAP43; Gap43; bnb; gap43", "protein_names_uniprotkb": "Protein bangles and beads", "protein_names_refseq": "Bangles-n-beads; CG7088-PC; bangles and beads, isoform C; bangles and beads; bnb-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7088)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;1551578;18327897;2693037", "class_list": "", "function": "May play an important role during development., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4V4R4;Q0KHQ7;Q9VWQ0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0042063 gliogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29746-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29747-1", "uniprot_id": "CREBA_DROME", "mass": 56342.0, "length": 516, "protein_name": "Cyclic AMP response element-binding protein A", "gene_name": "CrebA", "organism": "Fruit fly", "refseq_name": "Cyclic-AMP response element binding protein A, isoform A", "refseq_ac": "NP_524087", "gene_names_uniprotkb": "CrebA; Bbbf2; CG7450", "gene_names_refseq": "BBF-2; BBF2_DROME; BOX B Binding Factor-2; Bbbf2; BcDNA:SD05937; CG7450; CRE-BP; CREB-A; CREB-a; CREBA; CREB; Creb A; Creb-A; CrebA; Creb; DM4; Dmel\\CG7450; crebA; creba; creb; dCREB-A; dCREBA; dCREB; dCreb-A; dCrebA; l(3)03576", "protein_names_uniprotkb": "Cyclic AMP response element-binding protein A; BBF-2; Box B-binding factor 2; cAMP response element-binding protein A; dCREB-A", "protein_names_refseq": "Box B-binding factor 2; CG7450-PA; CREB-binding protein; CrebA-PA; Cyclic-AMP response element binding protein A, isoform A; cAMP response element binding protein A; cAMP response element binding protein; cyclic AMP response element binding protein; dCREB-A", "tax_id": 7227, "disease": "osteogenesis imperfecta type 16 (Disease Ontology:DOID:0110345)", "pathway": " (dme:Dmel_CG7450)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;1508208;1532159;18327897", "class_list": "", "function": "Transcriptional activator. Binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes. BBF-2 may play a role in fat body gene expression. It binds the consensus sequence 5'-T[AC]NACGTAN[TG]C-3'., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24282;Q64M72;Q8MQX0;Q9VUQ4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0042645 mitochondrial nucleoid;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29747-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30974-1", "uniprot_id": "TLR1_DROME", "mass": 58020.0, "length": 504, "protein_name": "Tachykinin-like peptides receptor 86C", "gene_name": "TkR86C", "organism": "Fruit fly", "refseq_name": "Tachykinin-like receptor at 86C, isoform A", "refseq_ac": "NP_524304", "gene_names_uniprotkb": "TkR86C; CG6515; NKD; Takr86C", "gene_names_refseq": "CG6515; DmNTLR; Dmel\\CG6515; NKD12; NKD; NKr; Nkd; TAKR86C; TKR86C; TakR86C; Takr86C; Tk-R 86C; TkR86C; TkR86c", "protein_names_uniprotkb": "Tachykinin-like peptides receptor 86C; NKD", "protein_names_refseq": "CG6515-PA; Tachykinin-like receptor at 86C, isoform A; Takr86C; TkR86C-PA; natalisin receptor; neurokinin receptor from drosophila; neuropeptide receptor; tachykinin receptor", "tax_id": 7227, "disease": "colitis (Disease Ontology:DOID:0060180); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dme:Dmel_CG6515)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;1370464;7547478", "class_list": "", "function": "Receptor for tachykinin-like peptides., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9VGX8", "ec_number_list": "", "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004995 tachykinin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007217 tachykinin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P30974-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31264-1", "uniprot_id": "HMPB_DROME", "mass": 83747.0, "length": 782, "protein_name": "Homeotic protein proboscipedia", "gene_name": "pb", "organism": "Fruit fly", "refseq_name": "proboscipedia, isoform A", "refseq_ac": "NP_476669", "gene_names_uniprotkb": "pb; CG31481", "gene_names_refseq": "BG:DS01719.1; CG17880; CG31481; Dmel\\CG31481; Dmpb; PB; Pb; l(3)04498; pb; pd; pr", "protein_names_uniprotkb": "Homeotic protein proboscipedia", "protein_names_refseq": "CG31481-PA; pb-PA; proboscipedia, isoform A; proboscipedia; proboscopedia; proposcipedia", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31481)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;1348688;40245499", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O97058;Q4JFI5;Q9VI44", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007381 specification of segmental identity, labial segment;GO:0048728 proboscis development;GO:0007382 specification of segmental identity, maxillary segment", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P31264-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32392-1", "uniprot_id": "ARP3_DROME", "mass": 47033.0, "length": 418, "protein_name": "Actin-related protein 3", "gene_name": "Arp3", "organism": "Fruit fly", "refseq_name": "Actin-related protein 3, isoform B", "refseq_ac": "NP_001261559", "gene_names_uniprotkb": "Arp3; Actr66B; Arp66B; CG7558", "gene_names_refseq": "ARP3; AcTr66B; Actr66B; Arp3; Arp66B; Arp; CG7558; Dmel\\CG7558; anon-WO0172774.138; arp3; arp66B; arp66b; schwachling", "protein_names_uniprotkb": "Actin-related protein 3; Actin-2; Actin-like protein 3; Actin-like protein 66B", "protein_names_refseq": "Actin-related protein 3, isoform B; Actin-related protein 66B; Actin-related protein; Arp3-PB; CG7558-PB; actin-related protein-3; schwachling", "tax_id": 7227, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); opisthorchiasis (Disease Ontology:DOID:13768); glioblastoma (Disease Ontology:DOID:3068); gallbladder carcinoma (Disease Ontology:DOID:4948); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG7558); (R-DME-2029482); (R-DME-3928662); (R-DME-5663213); (R-DME-8856828)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;25739458;8274139", "class_list": "", "function": "Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). Required during embryogenesis for the developmental migration of tail hemocytes anteriorly, along the ventral midline (PubMed:25739458)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PEY5;Q9VSD5", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0005885 Arp2/3 protein complex;GO:0005652 nuclear lamina", "go_biological_process": "GO:0072553 terminal button organization;GO:0006886 intracellular protein transport;GO:0030036 actin cytoskeleton organization;GO:0030032 lamellipodium assembly;GO:0007520 myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32392-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32748-1", "uniprot_id": "PYRD_DROME", "mass": 44342.0, "length": 405, "protein_name": "Dihydroorotate dehydrogenase (quinone), mitochondrial", "gene_name": "Dhod", "organism": "Fruit fly", "refseq_name": "dihydroorotate dehydrogenase, isoform A", "refseq_ac": "NP_477224", "gene_names_uniprotkb": "Dhod; CG9741", "gene_names_refseq": "CG9741; DHODH; DHOD; Dhod; Dmel\\CG9741; dhod; l(3)s3512", "protein_names_uniprotkb": "Dihydroorotate dehydrogenase (quinone), mitochondrial; 1.3.5.2; DHOdehase; Dihydroorotate oxidase", "protein_names_refseq": "CG9741-PA; Dhod-PA; dihydroorotate dehydrogenase, isoform A; dihydroorotate dehydrogenase", "tax_id": 7227, "disease": "postaxial acrofacial dysostosis (Disease Ontology:DOID:0111259)", "pathway": " (dme:Dmel_CG9741); (R-DME-500753)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;2482933;8444342", "class_list": "", "function": "Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8INQ4;Q8INQ5;Q9VHP2", "ec_number_list": "1.3.5.2", "go_molecular_function": "GO:0004152 dihydroorotate dehydrogenase activity;GO:0106430 dihydroorotate dehydrogenase (quinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0009220 pyrimidine ribonucleotide biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P32748-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33269-1", "uniprot_id": "CP4D1_DROME", "mass": 58703.0, "length": 512, "protein_name": "Cytochrome P450 4d1", "gene_name": "Cyp4d1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 4d1, isoform A", "refseq_ac": "NP_476907", "gene_names_uniprotkb": "Cyp4d1; CG3656; CYT-P450-D1", "gene_names_refseq": "4d1; CG3656; CYP4D1; CYP6D1; Cyp4D1; Cyp4d1; Cyt-P450-4D1; Dmel\\CG3656; EG:87B1.1; P-450; P450; cyp4d1", "protein_names_uniprotkb": "Cytochrome P450 4d1; 1.14.-.-; CYPIVD1", "protein_names_refseq": "CG3656-PA; Cyp4d1-PA; P450 CYPD1; cytochrome P450 4D1; cytochrome P450 4d1, isoform A; cytochrome P450-4d1; cytochrome P450", "tax_id": 7227, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); protein-energy malnutrition (Disease Ontology:DOID:11801); hypothyroidism (Disease Ontology:DOID:1459); endometriosis (Disease Ontology:DOID:289); placental insufficiency (Disease Ontology:DOID:3891)", "pathway": " (dme:Dmel_CG3656); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;10731137;12537569;12537572;1605861;25855066", "class_list": "", "function": "Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18644;O18653;O18664;Q8MS75;Q9W515;Q9W516", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P33269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33270-1", "uniprot_id": "CP6A2_DROME", "mass": 58685.0, "length": 506, "protein_name": "Cytochrome P450 6a2", "gene_name": "Cyp6a2", "organism": "Fruit fly", "refseq_name": "cytochrome P450 6a2", "refseq_ac": "NP_523628", "gene_names_uniprotkb": "Cyp6a2; CG9438; CYT-P450-B1", "gene_names_refseq": "143127_at; 6a2; 91-R; 91R; CG9438; CYP6A2; CYP6a2; Cyp6A2; Cyp6a2; Cyp6a; Cyt-P450-B1; Dmel\\CG9438; P-450-B; P-450; P450-B1; P450-B; P450; cyp6a2", "protein_names_uniprotkb": "Cytochrome P450 6a2; 1.14.-.-; CYPVIA2; Cytochrome P450-B1", "protein_names_refseq": "CG9438-PA; Cyp6a2-PA; cytochrome P450 6a2; cytochrome P450 B1; cytochrome P450-6a2; cytochrome P450-B1; cytochrome P450", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9438)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;1317576;8625948;9407006", "class_list": "", "function": "Is involved in the breakdown of synthetic insecticides and may be involved in the metabolism of insect hormones., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P91669;Q5U1C1;Q9V9A2", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0031000 response to caffeine;GO:0046680 response to DDT", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P33270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35220-1", "uniprot_id": "CTNA_DROME", "mass": 102444.0, "length": 917, "protein_name": "Catenin alpha", "gene_name": "alpha-Cat", "organism": "Fruit fly", "refseq_name": "alpha catenin, isoform A", "refseq_ac": "NP_524219", "gene_names_uniprotkb": "alpha-Cat; CG17947; CT39986; D-alpha-catenin; Dalpha-Cat; Dalpha-cat; DalphaC; Dalphacat; Dmcatp; Dmel\\CG17947; Dmel_CG17947; LD30423p; a-Cat; a-cat; alpha-CAT; alpha-catenin; alpha-cat; alpha-ctn; alphaCAT; alphaCatenin; alphaCat; alphacat", "gene_names_refseq": "CG17947; CT39986; D-alpha-catenin; Dalpha-Cat; Dalpha-cat; DalphaC; Dalphacat; Dmcatp; Dmel\\CG17947; LD30423p; a-Cat; a-cat; alpha-CAT; alpha-Cat; alpha-catenin; alpha-cat; alpha-ctn; alphaCAT; alphaCatenin; alphaCat; alphacat", "protein_names_uniprotkb": "Catenin alpha", "protein_names_refseq": "CG17947-PA; D-alpha-catenin; Dalpha-Catenin; Dalpha-cadherin; a-catenin; alpha catenin, isoform A; alpha catenin; alpha-Cat-PA; alpha-Catenin; alpha-Ctenin; alphaCatenin; dalphacatenin", "tax_id": 7227, "disease": "patterned macular dystrophy 2 (Disease Ontology:DOID:0060864); complex cortical dysplasia with other brain malformations 9 (Disease Ontology:DOID:0061138); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); childhood-onset asthma (Disease Ontology:DOID:0080815); occupational asthma (Disease Ontology:DOID:0080820); arrhythmogenic right ventricular dysplasia 13 (Disease Ontology:DOID:0110084); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); invasive lobular carcinoma (Disease Ontology:DOID:3457); renal cell carcinoma (Disease Ontology:DOID:4450); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (dme:Dmel_CG17947); (R-DME-5218920); (R-DME-525793); (R-DME-9764561); (R-DME-9958825)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;25653389;25739458;26109356;26109357;8501118", "class_list": "", "function": "Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q960Y2;Q9W5V9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005198 structural molecule activity;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0016342 catenin complex", "go_biological_process": "GO:0060323 head morphogenesis;GO:0016477 cell migration;GO:0098609 cell-cell adhesion;GO:0034332 adherens junction organization;GO:0034333 adherens junction assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P35220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35992-5", "uniprot_id": "PTP10_DROME", "mass": 222740.0, "length": 1990, "protein_name": "Tyrosine-protein phosphatase 10D", "gene_name": "Ptp10D", "organism": "Fruit fly", "refseq_name": "protein tyrosine phosphatase 10D, isoform E", "refseq_ac": "NP_001138187", "gene_names_uniprotkb": "Ptp10D; CG1817", "gene_names_refseq": "10D; CG1817; CT4920; DPTP10D; DPTP[[10D]]; DPTP; Dmel\\CG1817; Dptp10D; PTP10D; Ptp10D; Ptp10d; Ptp10; R-PTP 10D; RPTP10d; dptp; ptp10D; ptp10d", "protein_names_uniprotkb": "Tyrosine-protein phosphatase 10D; 3.1.3.48; DPTP10D; Receptor-linked protein-tyrosine phosphatase 10D", "protein_names_refseq": "CG1817-PE; Ptp10D-PE; protein tyrosine phosphatase 10B; protein tyrosine phosphatase 10D, isoform E", "tax_id": 7227, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); brain glioma (Disease Ontology:DOID:0060108); colorectal carcinoma (Disease Ontology:DOID:0080199); sarcoma (Disease Ontology:DOID:1115); thrombocytopenia (Disease Ontology:DOID:1588); glioblastoma (Disease Ontology:DOID:3068); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); thyroid gland carcinoma (Disease Ontology:DOID:3963); breast angiosarcoma (Disease Ontology:DOID:4511); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG1817)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;1657401;1657402;40245499", "class_list": "", "function": "May have a role in axon outgrowth and guidance., [UniProtKB, PubMed]", "predicted_glycosites": 27, "predicted_n_glycosites": 27, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 28, "binding_glycan_count": 0, "secondary_ac_list": "A4V4B4;B7Z142;F0JAM3;M9PEB6;M9PJI5;Q0KHT5;Q86NN9;Q8IR87;Q9VYW1", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.-;3.1.3.2;3.1.3.27", "go_molecular_function": "GO:0005001 transmembrane receptor protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0140177 membrane-membrane adaptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0045177 apical part of cell", "go_biological_process": "GO:0099156 cell-cell signaling via exosome;GO:0007165 signal transduction;GO:0007417 central nervous system development;GO:0007616 long-term memory;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35992-5", "record_type": "protein" }, { "uniprot_canonical_ac": "P39205-1", "uniprot_id": "CIN_DROME", "mass": 65733.0, "length": 601, "protein_name": "Molybdenum cofactor synthesis protein cinnamon", "gene_name": "cin", "organism": "Fruit fly", "refseq_name": "cinnamon, isoform A", "refseq_ac": "NP_477030", "gene_names_uniprotkb": "cin; CG2945", "gene_names_refseq": "CG2945; CIN; Dmel\\CG2945; EG:BACR37P7.3; cin; fs(1)M50; l(1)1Ae; l(1)G0142", "protein_names_uniprotkb": "Molybdenum cofactor synthesis protein cinnamon; Domain E; Domain G", "protein_names_refseq": "CG2945-PA; cin-PA; cinnamon, isoform A", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); molybdenum cofactor deficiency type C (Disease Ontology:DOID:0111166); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (dme:Dmel_CG2945); (R-DME-947581)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10394904;10731132;10731137;12537569;12537572;17372656;8088525", "class_list": "", "function": "Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KHX9;Q9U1M0;Q9V3E2", "ec_number_list": "2.10.1.1;2.7.7.75", "go_molecular_function": "GO:0061598 molybdopterin adenylyltransferase activity;GO:0061599 molybdopterin molybdotransferase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0045211 postsynaptic membrane;GO:0099572 postsynaptic specialization", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0072579 glycine receptor clustering;GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P39205-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39572-1", "uniprot_id": "GIANT_DROME", "mass": 49169.0, "length": 448, "protein_name": "Protein giant", "gene_name": "gt", "organism": "Fruit fly", "refseq_name": "giant", "refseq_ac": "NP_525049", "gene_names_uniprotkb": "gt; CG7952", "gene_names_refseq": "CG7952; DM17; Dm-gt; Dmel\\CG7952; EG:BACH7M4.5; GIAN_DROME; GT; Giant; Gt; gt; l(1)3Aa; l(1)giant", "protein_names_uniprotkb": "Protein giant", "protein_names_refseq": "CG7952-PB; giant; gt-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7952)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731137;12537572;1576969", "class_list": "", "function": "Represses the expression of both the krueppel and knirps segmentation gap genes. Binds, in vitro, to the krueppel regulatory elements CD1 and CD2. It is required in the early embryo for the development of portions of the head and abdomen., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EQS3;Q7YU39;Q9V3N3", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007354 zygotic determination of anterior/posterior axis, embryo;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0040015 negative regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P39572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40589-1", "uniprot_id": "WNT4_DROME", "mass": 58685.0, "length": 539, "protein_name": "Protein Wnt-4", "gene_name": "Wnt4", "organism": "Fruit fly", "refseq_name": "Wnt oncogene analog 4, isoform B", "refseq_ac": "NP_001260187", "gene_names_uniprotkb": "Wnt4; CG4698; Wnt-4", "gene_names_refseq": "CG4698; DWnt-4; DWnt4; Dm DWnt4; Dmel\\CG4698; Dwnt-4; Dwnt4; WNT4; Wnt-4; Wnt4; Wnt; anon-EST:Liang-2.4; clone 2.4; dWnt4; wnt-4; wnt4", "protein_names_uniprotkb": "Protein Wnt-4; dWnt-4", "protein_names_refseq": "CG4698-PB; Wnt oncogene analog 4, isoform B; Wnt4-PB", "tax_id": 7227, "disease": "breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (dme:Dmel_CG4698); (R-DME-3238698)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;11970894;12537569;12537572;7867502", "class_list": "", "function": "Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Acts downstream of homeotic complex genes in the visceral mesoderm and is required for embryonic segmentation. Also required for cell movement and FAK regulation during ovarian morphogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8MPQ1;Q8SWU3;Q9VM29", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0016477 cell migration;GO:0030182 neuron differentiation;GO:0016055 Wnt signaling pathway;GO:0060070 canonical Wnt signaling pathway;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40589-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40688-1", "uniprot_id": "SWA_DROME", "mass": 62070.0, "length": 548, "protein_name": "Protein swallow", "gene_name": "swa", "organism": "Fruit fly", "refseq_name": "swallow", "refseq_ac": "NP_511060", "gene_names_uniprotkb": "swa; CG3429", "gene_names_refseq": "CG3429; Dmel\\CG3429; Swa; anon-WO0140519.70; fs(1)1497; fs(1)1502; fs(1)M11-999; fs(1)M13C82; fs(1)M44; fs(1)m44; swa; sww", "protein_names_uniprotkb": "Protein swallow", "protein_names_refseq": "CG3429-PA; swa-PA; swallow", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3429)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;1806330;18327897;7507030", "class_list": "", "function": "Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W400", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007015 actin filament organization;GO:0051301 cell division;GO:0008595 anterior/posterior axis specification, embryo;GO:0045450 bicoid mRNA localization;GO:0007317 regulation of pole plasm oskar mRNA localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40808-1", "uniprot_id": "DCOR2_DROME", "mass": 44153.0, "length": 393, "protein_name": "Ornithine decarboxylase 2", "gene_name": "Odc2", "organism": "Fruit fly", "refseq_name": "ornithine decarboxylase 2", "refseq_ac": "NP_477053", "gene_names_uniprotkb": "Odc2; CG8719", "gene_names_refseq": "CG8719; Dmel\\CG8719; Odc2; dodc2", "protein_names_uniprotkb": "Ornithine decarboxylase 2; 4.1.1.17; ODC; dODC2", "protein_names_refseq": "CG8719-PA; Odc2-PA; ornithine decarboxylase 2", "tax_id": 7227, "disease": "atrichia with papular lesions (Disease Ontology:DOID:0060689); pneumocystosis (Disease Ontology:DOID:11339); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG8719); (R-DME-350562); (R-DME-351143); (R-DME-351202)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537572;8329117", "class_list": "", "function": "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V353", "ec_number_list": "4.1.1.17;3.4.19.-;5.6.1.5", "go_molecular_function": "GO:0004586 ornithine decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0033387 putrescine biosynthetic process from arginine, via ornithine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P40808-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40946-1", "uniprot_id": "ARF6_DROME", "mass": 20005.0, "length": 175, "protein_name": "ADP-ribosylation factor 6", "gene_name": "Arf6", "organism": "Fruit fly", "refseq_name": "ADP ribosylation factor 6, isoform A", "refseq_ac": "NP_523751", "gene_names_uniprotkb": "Arf6; Arf3; Arf51F; CG8156", "gene_names_refseq": "AFR51F; ARF3; ARF6; ARFIII; Arf3; Arf51F; Arf51f; Arf6; CG8156; Dm Arf51F; Dmel\\CG8156; EP(2)2612; LD12493; P40946; arf51F; arf51f; arf6; d-Arf6; dARFIII; dArf6", "protein_names_uniprotkb": "ADP-ribosylation factor 6; ADP ribosylation factor at 51F; ADP-ribosylation factor 3; ARF6", "protein_names_refseq": "ADP ribosylation factor 51F; ADP ribosylation factor 6, isoform A; ADP ribosylation factor III; ADP ribosylation factor at 51F; Arf6-PA; CG8156-PA", "tax_id": 7227, "disease": "candidiasis (Disease Ontology:DOID:1508); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG8156); (R-DME-8854214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;21976699;28607459;8063793", "class_list": "", "function": "GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Promotes cell movement and remodeling of the actin cytoskeleton during compound eye morphogenesis (PubMed:21976699). Required for normal ethanol-induced tolerance and preference (PubMed:28607459). Probably after Efa6-mediated activation, counteracts ethanol-induced sedation (PubMed:28607459)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZH7;Q0E966;Q9V7B0", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0097305 response to alcohol;GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0048149 behavioral response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41094-1", "uniprot_id": "RS18_DROME", "mass": 17612.0, "length": 152, "protein_name": "Small ribosomal subunit protein uS13", "gene_name": "RpS18", "organism": "Fruit fly", "refseq_name": "ribosomal protein S18, isoform A", "refseq_ac": "NP_476964", "gene_names_uniprotkb": "RpS18; CG8900", "gene_names_refseq": "BcDNA:RH43343; B; CG8900; Dmel\\CG8900; M(2)56F; RS18_DROME; RpS18; Rps18; S13; S18; anon-56Fa; anon-EST:Posey27; anon-EST:fe2D3; rpS18", "protein_names_uniprotkb": "Small ribosomal subunit protein uS13; 40S ribosomal protein S18", "protein_names_refseq": "CG8900-PA; RpS18-PA; anon-fast-evolving-2D3; ribosomal protein S18, isoform A; transcription unit B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8900); (R-DME-156827); (R-DME-1799339); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 12, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;23636399;8163194", "class_list": "", "function": "Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1WWH7;Q8MT19;Q9V911", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0015935 small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41094-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41375-1", "uniprot_id": "IF2B_DROME", "mass": 35218.0, "length": 312, "protein_name": "Eukaryotic translation initiation factor 2 subunit 2", "gene_name": "eIF2beta", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 2 subunit beta", "refseq_ac": "NP_524043", "gene_names_uniprotkb": "eIF2beta; CG4153; eIF-2beta", "gene_names_refseq": "CG4153; D-eIF2beta; Dmel\\CG4153; Eif2beta; IF2B; eIF-2beta; eIF-2; eIF2-beta; eIF2beta; elF2beta", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eIF2-beta", "protein_names_refseq": "CG4153-PA; eIF-2 subunit beta; eIF2beta-PA; eukaryotic initiation factor 2beta; eukaryotic translation initiation factor 2 subunit beta", "tax_id": 7227, "disease": "leukodystrophy (Disease Ontology:DOID:10579)", "pathway": " (dme:Dmel_CG4153); (R-DME-156827); (R-DME-381042); (R-DME-382556); (R-DME-72649); (R-DME-72695); (R-DME-72702); (R-DME-72731); (R-DME-9840373)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;8194763", "class_list": "", "function": "Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYX9;Q9VTZ3", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0043614 multi-eIF complex;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0016199 axon midline choice point recognition;GO:0034976 response to endoplasmic reticulum stress;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41375-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41964-1", "uniprot_id": "DMYC_DROME", "mass": 7752.0, "length": 70, "protein_name": "Drosomycin", "gene_name": "Drs", "organism": "Fruit fly", "refseq_name": "drosomycin", "refseq_ac": "NP_523901", "gene_names_uniprotkb": "Drs; CG10810; CRP", "gene_names_refseq": "BcDNA:LP03851; CG10810; Crp; DIM 19; DIM 21; DROM; DROS; DRO; DRS; Dmel\\CG10810; Drm; Drom; Droso; Dros; Drs; IM21; dmy1; drm; drom; drosomycin; dros; drsm; drs", "protein_names_uniprotkb": "Drosomycin; Cysteine-rich peptide", "protein_names_refseq": "CG10810-PA; Cysteine-rich-protein; Drosomycin-B; Drs-PA; cysteine-rich peptide; drosomcycin; drosomycin precursor; drosomycine; drosomycin; drosomyocin; drosomysin; drosophila immune induced molecule 19; immune induced molecule 21", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG10810)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537569;12537572;12872120;16157672;18854145;19590012;22022271;7806546;8808632;9300487;9736738", "class_list": "", "function": "Possesses antifungal activity and is active against a relatively broad spectrum of filamentous fungi (PubMed:12872120, PubMed:8808632). It inhibits spore germination at high concentrations and at low concentrations delays growth of hyphae which subsequently exhibit abnormal morphology (PubMed:7806546). Spz C-106 in the hemolymph controls expression of the antifungal peptide by acting as a ligand of Tl and inducing an intracellular signaling pathway (PubMed:8808632). Part of a psh-dependent Toll pathway, which may function in activating the systematic immune response in response to localized melanization of the tracheal system (PubMed:18854145)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2UYN5;Q9VZQ2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006952 defense response;GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0050829 defense response to Gram-negative bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P41964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42207-1", "uniprot_id": "SEPT1_DROME", "mass": 41131.0, "length": 361, "protein_name": "Septin-1", "gene_name": "Septin1", "organism": "Fruit fly", "refseq_name": "septin 1", "refseq_ac": "NP_523430", "gene_names_uniprotkb": "Septin1; CG1403; Diff6; Sep1; iby", "gene_names_refseq": "38960; CG1403; DSep1; Diff6; Dmel\\CG1403; Sep1; Septin1; anon-19Fa; dSEPT1; iby; sep1; tu1", "protein_names_uniprotkb": "Septin-1; DIFF6 protein homolog; Protein innocent bystander", "protein_names_refseq": "CG1403-PA; Septin-1; Septin1-PA; innocent bystander; septin 1; septin1; septin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1403)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;17372656;17456438;8590810;9520435", "class_list": "", "function": "Involved in cytokinesis (Probable). May be involved in p53-dependent apoptosis (PubMed:17456438)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IQ47;Q9VRH5", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005940 septin ring;GO:0015630 microtubule cytoskeleton;GO:0032154 cleavage furrow;GO:0031105 septin complex;GO:0032153 cell division site", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0008104 intracellular protein localization;GO:0042461 photoreceptor cell development;GO:0042060 wound healing;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P42207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42325-1", "uniprot_id": "NCAH_DROME", "mass": 21894.0, "length": 190, "protein_name": "Neurocalcin homolog", "gene_name": "Nca", "organism": "Fruit fly", "refseq_name": "neurocalcin", "refseq_ac": "NP_788543", "gene_names_uniprotkb": "Nca; CG7641", "gene_names_refseq": "CG7641; Dmel\\CG7641; Ncalc; Nca; nca", "protein_names_uniprotkb": "Neurocalcin homolog; DrosNCa", "protein_names_refseq": "CG7641-PA; Frequenin3; Nca-PA; neurocalcin", "tax_id": 7227, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); torsion dystonia 2 (Disease Ontology:DOID:0090038); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (dme:Dmel_CG7641); (R-DME-2514859); (R-DME-451308)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;30865587;7989365;8626592", "class_list": "", "function": "Calcium-binding protein that is essential for promoting night-time sleep and inhibiting nocturnal hyperactivity (PubMed:30865587, PubMed:7989365). During the night-time it promotes sleep by limiting synaptic output from arousal- and wake-promoting neurons within the C01- and A05- domains that include the mushroom body, and the antennal mechanosensory and motor center (PubMed:30865587). Regulated by the circadian clock network and light-sensing circuits that include the CRY photoreceptor; it is likely that both of these internal and external cues are required to define the temporal window (the night-time) during which this protein functions (PubMed:30865587). Inhibits the phosphorylation of rhodopsin in a calcium-dependent manner (PubMed:8626592)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VW67", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0045938 positive regulation of circadian sleep/wake cycle, sleep;GO:0009966 regulation of signal transduction;GO:1902848 negative regulation of neuronal signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P42325-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42787-1", "uniprot_id": "CBPD_DROME", "mass": 158789.0, "length": 1406, "protein_name": "Carboxypeptidase D", "gene_name": "svr", "organism": "Fruit fly", "refseq_name": "silver, isoform I", "refseq_ac": "NP_001138141", "gene_names_uniprotkb": "svr; CG18503; CG32818; CG4122; CPD; CP; CpepE; CypD; Dmel\\CG4122; Dmel_CG4122; EG:171D11.3; EP(X)0356; cc; dwp; l(1)1Bd; poi; slv", "gene_names_refseq": "CG18503; CG32818; CG4122; CPD; CP; CpepE; CypD; Dmel\\CG4122; EG:171D11.3; EP(X)0356; cc; dwp; l(1)1Bd; poi; slv; svr", "protein_names_uniprotkb": "Carboxypeptidase D; 3.4.17.22; Metallocarboxypeptidase D; Protein silver", "protein_names_refseq": "CG4122-PI; DmSilver; carboxypeptidase D; carboxypeptidase E; chlorotic; dwarp; pointed; silver, isoform I; silver; svr-PI", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4122)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10731132;10731137;12393882;12537568;12537572;12537573;12537574;16110336;16556608;16676361;17569856;17569867;17893096;18327897;20386952;20600119;25589440;26109356;26109357;27430952;31309630;7568156;8000074", "class_list": "", "function": "Metallocarboxypeptidase that catalyzes the release of C-terminal arginine or lysine residues from peptides and proteins (PubMed:12393882, PubMed:16556608, PubMed:20386952, PubMed:20600119, PubMed:31309630). Functionally important for processing a broad range of proteins including growth factors, peptide hormones (such as Akh) and neuropeptides (PubMed:16556608, PubMed:20386952, PubMed:20600119, PubMed:27430952, PubMed:31309630). Consequently, it is involved in a wide range of processes including viability, memory formation, locomotive activity, wing formation, and peptide-regulated behaviors such as starvation-induced hyperactivity, appetitive gustatory preference, and cold and ethanol sensitivity (PubMed:20386952, PubMed:20600119, PubMed:27430952, PubMed:31309630). Key enzyme in neuropeptide processing (PubMed:31309630). Involved in regulation of memory formation, possibly via the insulin pathway in neurosecretory cells (PubMed:27430952)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "A2RVE4;B7Z112;C7LAH0;D0Z763;D3DME3;O46058;Q24094;Q24095;Q9W5F3;Q9W5F4;Q9W5F5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity;GO:0042302 structural constituent of cuticle", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process;GO:0007616 long-term memory;GO:0061837 neuropeptide processing;GO:0007476 imaginal disc-derived wing morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P42787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P45594-1", "uniprot_id": "CADF_DROME", "mass": 17153.0, "length": 148, "protein_name": "Cofilin/actin-depolymerizing factor homolog", "gene_name": "tsr", "organism": "Fruit fly", "refseq_name": "twinstar", "refseq_ac": "NP_477034", "gene_names_uniprotkb": "tsr; CG4254; Cadf", "gene_names_refseq": "12/8; ADF/cofilin; ADF; Adf; CG4254; Cadf; Cfl; Cofilin; D-cof; D61; DmCFL; Dmel\\CG4254; T8; Tsr; Twinstar; cfl; cofilin/ADF; cofilin/actin depolymerizing factor homolog; cofilin; l(2)03101; l(2)k03101; l(2)k05633; l(2)k13409; ntf; tsr", "protein_names_uniprotkb": "Cofilin/actin-depolymerizing factor homolog; Protein D61; Protein twinstar", "protein_names_refseq": "ADFcofilin; CG4254-PA; Cofilin/actin depolymerizing factor-like; DCofilin; actin-depolymerizing factor; cofilin; no terminal filament; tsr-PA; twin star; twinstar", "tax_id": 7227, "disease": "West syndrome (Disease Ontology:DOID:0050562); vitamin B12 deficiency (Disease Ontology:DOID:0050731); autism spectrum disorder (Disease Ontology:DOID:0060041); nemaline myopathy 7 (Disease Ontology:DOID:0110934); brain compression (Disease Ontology:DOID:11457); nephrotic syndrome (Disease Ontology:DOID:1184); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); gallbladder carcinoma (Disease Ontology:DOID:4948); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (dme:Dmel_CG4254)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10731132;11027607;11175754;11832213;12537572;15572110;15952742;16571634;18423434;20026655;21205790;22323606;22912811;25411210;27041568;30917306;8183953;8522587", "class_list": "", "function": "Exhibits F-actin depolymerizing activity and regulates actin cytoskeleton dynamics (PubMed:21205790). Required for cytokinesis in both mitotic and meiotic cells and for aster migration and separation (PubMed:8522587). Promotes cell motility during ovary development and oogenesis (PubMed:11175754). During larval development, required for the cell rearrangement needed for formation of terminal filaments which are stacks of somatic cells that are important for the initiation of ovarioles (PubMed:11175754). Also required for border cell migration during oogenesis (PubMed:11175754). During border cell migration, required for actin turnover and lamellipodial protrusion (PubMed:21205790). Required for the establishment of planar cell polarity (PCP) where cells adopt a uniform orientation within the plane of an epithelium (PubMed:16571634). During establishment of PCP, required for the redistribution of the PCP core proteins fz and stan/fmi to the proximodistal cell boundary (PubMed:16571634). During pupal development, required for elongation of the retinal cell body and for rhabdomere morphogenesis (PubMed:18423434). Required for mushroom body neuroblast proliferation and axon growth (PubMed:15572110). Plays a role in the positive regulation of protein secretion (PubMed:20026655). Plays a role in the regulation of nuclear localization of actin (PubMed:22323606). Required for the maintenance of epithelial integrity by controlling cell junctions and is also necessary for cell survival and tissue growth through regulation of JNK and yki signaling (PubMed:27041568)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C6SV25;Q9W1C4", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0016363 nuclear matrix", "go_biological_process": "GO:0048749 compound eye development;GO:0007015 actin filament organization;GO:0007409 axonogenesis;GO:0050714 positive regulation of protein secretion;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P45594-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P45890-1", "uniprot_id": "ARP6_DROME", "mass": 45415.0, "length": 398, "protein_name": "Actin-related protein 6", "gene_name": "Arp6", "organism": "Fruit fly", "refseq_name": "Actin-related protein 6", "refseq_ac": "NP_511165", "gene_names_uniprotkb": "Arp6; Acrp; Actr13E; Arp4; CG11678", "gene_names_refseq": "ARP(13E); ARP13E; ARP; Acrp; Actr13E; Arp13E; Arp4; Arp6; CG11678; Dmel\\CG11678; actr13E; arp4; dArp6", "protein_names_uniprotkb": "Actin-related protein 6; Actin-like protein 13E; dArp6", "protein_names_refseq": "Actin-related protein 13E; Actin-related protein 6; Arp6-PA; CG11678-PA; actin-related protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11678)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;32432549;8308899;9378752", "class_list": "", "function": "Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXQ9", "ec_number_list": "", "go_molecular_function": "GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0000785 chromatin;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P45890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46223-1", "uniprot_id": "RL7A_DROME", "mass": 30732.0, "length": 271, "protein_name": "Large ribosomal subunit protein eL8", "gene_name": "RpL7A", "organism": "Fruit fly", "refseq_name": "ribosomal protein L7A, isoform E", "refseq_ac": "NP_001284944", "gene_names_uniprotkb": "RpL7A; CG3314; Dmel\\CG3314; Dmel_CG3314; L7A; L7a; L8e; RPL7a; Rp L7A; RpL7a; SURF-3; rpL7a", "gene_names_refseq": "CG3314; Dmel\\CG3314; L7A; L7a; L8e; RPL7a; Rp L7A; RpL7A; RpL7a; Surf-3/rpL7a; Surf3/rpL7a", "protein_names_uniprotkb": "Large ribosomal subunit protein eL8; 60S ribosomal protein L7a", "protein_names_refseq": "CG3314-PE; RpL7A-PE; ribosomal protein L7A, isoform E; ribosomal protein L7A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3314); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357;7739520", "class_list": "", "function": "Component of the ribosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V411;Q9W3Z2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000470 maturation of LSU-rRNA;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P46223-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47980-1", "uniprot_id": "TIS11_DROME", "mass": 47166.0, "length": 436, "protein_name": "Protein TIS11", "gene_name": "Tis11", "organism": "Fruit fly", "refseq_name": "Tis11 zinc finger protein, isoform C", "refseq_ac": "NP_001259490", "gene_names_uniprotkb": "Tis11; CG4070; TIScc1", "gene_names_refseq": "CG4070; DTIS11-RC; DTIS11; Dmel\\CG4070; TIS11cc1; TIS11; TIScc1; Tis11; Ts11; anon-EST:Liang-1.28; clone 1.28; dTIS11; dTTP; dTis11; l(1)G0124; tis-11; tis11", "protein_names_uniprotkb": "Protein TIS11; dTIS11", "protein_names_refseq": "CG4070-PC; Tis11 homolog; Tis11 zinc finger protein, isoform C; Tis11-PC", "tax_id": 7227, "disease": "breast cancer (Disease Ontology:DOID:1612); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (dme:Dmel_CG4070); (R-DME-450385); (R-DME-450513)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537572;7828883;7936658", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IR77;Q9VYK1", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47980-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48148-1", "uniprot_id": "RHO1_DROME", "mass": 21723.0, "length": 192, "protein_name": "Ras-like GTP-binding protein Rho1", "gene_name": "Rho1", "organism": "Fruit fly", "refseq_name": "Rho1, isoform A", "refseq_ac": "NP_477098", "gene_names_uniprotkb": "Rho1; CG8416", "gene_names_refseq": "19549712; 8416; AAF01186; CG8416; D-Rho1; DRho1; DRhoA; DRho; Dm Rho1; DmRHO-A; Dmel\\CG8416; Drho1; DrhoA; E3.10/J3.8; P48148; RHO1; RHOA; RHO; Rho A; Rho GTPase; Rho1; RhoA; RhoN19; Rho; dRho1; dRhoA; dnRho; l(2)52Fa; l(2)k02107b; n(2)k07236; rho1; rhoA; rho", "protein_names_uniprotkb": "Ras-like GTP-binding protein Rho1; 3.6.5.2", "protein_names_refseq": "CG8416-PA; Rho GTPase; Rho1, isoform A; Rho1-PA; RhoA kinase; RhoA; rho kinase; rho1 kinase", "tax_id": 7227, "disease": "fetal alcohol syndrome (Disease Ontology:DOID:0050665); peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG8416); (R-DME-114604); (R-DME-193634); (R-DME-198203); (R-DME-2173791); (R-DME-350368); (R-DME-350407); (R-DME-350480); (R-DME-392451); (R-DME-3928662); (R-DME-3928663); (R-DME-4086400); (R-DME-416482); (R-DME-416572); (R-DME-4420097); (R-DME-450728); (R-DME-5625740); (R-DME-5625900); (R-DME-5627117); (R-DME-5663220); (R-DME-5666185); (R-DME-5689896); (R-DME-6785631); (R-DME-6798695); (R-DME-8849471); (R-DME-8980692); (R-DME-9035034)", "pathway_count": 27, "publication_count": 19, "publication_id_list": "10323867;10556060;10570971;10731132;11301004;11874917;12537569;12537572;15269282;15556868;16469972;17507675;18701542;18723886;19576201;23853710;24535826;25739458;7835340", "class_list": "", "function": "Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan (PubMed:10556060, PubMed:24535826, PubMed:25739458). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10323867, PubMed:10556060). During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm (PubMed:24535826). During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). May have a role in eye development (PubMed:7835340). Involved in targeted recruitment of dia/diaphanous to apical membranes of polarized epithelial cells (PubMed:23853710)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZI6;Q0E958;Q9V3J0", "ec_number_list": "1.2.1.-;1.2.1.3;1.-.-.-;2.7.11.30;2.7.11.1;2.7.11.13;3.6.5.5;3.4.24.-;3.1.4.4;3.6.5.2;3.6.5.-;3.6.4.-;2.7.10.1;3.1.3.16;3.1.3.48;2.3.2.27;3.6.5.3;3.4.11.-;2.3.2.26;3.4.16.2;5.6.1.3;3.4.19.12;3.1.3.95;3.4.24.11", "go_molecular_function": "GO:0003779 actin binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0050770 regulation of axonogenesis;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P48148-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48588-1", "uniprot_id": "RS25_DROME", "mass": 13201.0, "length": 117, "protein_name": "Small ribosomal subunit protein eS25", "gene_name": "RpS25", "organism": "Fruit fly", "refseq_name": "ribosomal protein S25, isoform A", "refseq_ac": "NP_524315", "gene_names_uniprotkb": "RpS25; CG6684; RpS31", "gene_names_refseq": "CG6684; D25; Dmel\\CG6684; M(3)86D; M(3)S31; M(3)S32; M(3)s[32]; RPS25; Rp S25; RpS25; RpS31; Rps25; S25e; S25; anon-EST:Posey260; rpS25", "protein_names_uniprotkb": "Small ribosomal subunit protein eS25; 40S ribosomal protein S25", "protein_names_refseq": "CG6684-PA; RpS25-PA; minute (3) 86D; minute (3) S32; ribosomal protein S25, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6684); (R-DME-156827); (R-DME-1799339); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 12, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;23636399", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6IDV9;Q0KI84;Q8SZ71;Q9VGS0", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48588-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48592-1", "uniprot_id": "RIR2_DROME", "mass": 45115.0, "length": 393, "protein_name": "Ribonucleoside-diphosphate reductase subunit M2", "gene_name": "RnrS", "organism": "Fruit fly", "refseq_name": "ribonucleoside diphosphate reductase small subunit", "refseq_ac": "NP_525111", "gene_names_uniprotkb": "RnrS; CG8975", "gene_names_refseq": "CG8975; DmRNR2; Dmel\\CG8975; R2; RNR-S; RNR2; RNRS; RNrS; RnRs; Rnr2; RnrS; Rnrs; anon-WO0118547.148; dRNR2; rnr2; rnrS", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase subunit M2; 1.17.4.1; Ribonucleotide reductase small subunit", "protein_names_refseq": "CG8975-PA; RnrS-PA; ribonucleoside diphosphate reductase small subunit; ribonucleoside-diphosphate reductase small subunit; ribonucleotide reductase small subunit", "tax_id": 7227, "disease": "mitochondrial DNA depletion syndrome 8a (Disease Ontology:DOID:0080127); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111518); urinary bladder cancer (Disease Ontology:DOID:11054); pancreatic cancer (Disease Ontology:DOID:1793); endometrial adenocarcinoma (Disease Ontology:DOID:2870); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (dme:Dmel_CG8975); (R-DME-499943)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;8050359", "class_list": "", "function": "Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V640", "ec_number_list": "1.17.4.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "go_cellular_component": "GO:0005829 cytosol;GO:0005971 ribonucleoside-diphosphate reductase complex", "go_biological_process": "GO:0009263 deoxyribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48592-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48611-1", "uniprot_id": "PTPS_DROME", "mass": 19337.0, "length": 168, "protein_name": "6-pyruvoyl tetrahydrobiopterin synthase", "gene_name": "pr", "organism": "Fruit fly", "refseq_name": "purple", "refseq_ac": "NP_724244", "gene_names_uniprotkb": "pr; CG16784", "gene_names_refseq": "38B.9; CG16784; Dmel\\CG16784; PTPS; anon-38Bb; pr", "protein_names_uniprotkb": "6-pyruvoyl tetrahydrobiopterin synthase; 4.2.3.12; PTP synthase; PTPS; Protein purple; Sepiapterin synthase A", "protein_names_refseq": "CG16784-PC; pr-PC; purple", "tax_id": 7227, "disease": "BH4-deficient hyperphenylalaninemia A (Disease Ontology:DOID:0090106); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (dme:Dmel_CG16784); (R-DME-1474151)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;8846895", "class_list": "", "function": "Required for pigment and biopterin synthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0X1;Q9VIP5", "ec_number_list": "4.2.3.12;2.7.11.12", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003874 6-pyruvoyltetrahydropterin synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006726 eye pigment biosynthetic process;GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0006728 pteridine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48612-1", "uniprot_id": "PELO_DROME", "mass": 44212.0, "length": 395, "protein_name": "Protein pelota", "gene_name": "pelo", "organism": "Fruit fly", "refseq_name": "pelota", "refseq_ac": "NP_476982", "gene_names_uniprotkb": "pelo; CG3959", "gene_names_refseq": "CG3959; DmPelota; Dmel\\CG3959; PELO; Pelo Hbs1; Pelo; ms(2)01559; pelo", "protein_names_uniprotkb": "Protein pelota", "protein_names_refseq": "CG3959-PA; pelo-PA; pelota", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3959); (R-DME-9954714)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;16280348;26124316;29861391;30824860;7588080", "class_list": "", "function": "Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:29861391). In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Pelota-HBS1L complex promotes recruitment of pix, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity). Required prior to the first meiotic division for spindle formation and nuclear envelope breakdown during spermatogenesis (PubMed:7588080). Together with HBS1, promotes spermatid individualization during spermatogenesis (PubMed:30824860). Required for ovarian germ line stem cell self-renewal and oocyte development during oogenesis (PubMed:16280348). Together with HSB1, required for transposon silencing in the ovary and testis (PubMed:26124316). As part of the Pink1-regulated signaling, is recruited to damaged mitochondrial and is required for recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). Required for normal eye patterning and for mitotic divisions in the ovary (PubMed:7588080)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VL97", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990533 Dom34-Hbs1 complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0070651 nonfunctional rRNA decay;GO:0071025 RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P48612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49630-1", "uniprot_id": "RL36_DROME", "mass": 13502.0, "length": 115, "protein_name": "Large ribosomal subunit protein eL36", "gene_name": "RpL36", "organism": "Fruit fly", "refseq_name": "ribosomal protein L36, isoform E", "refseq_ac": "NP_001284750", "gene_names_uniprotkb": "RpL36; BcDNA:AT29875; CG7622; Dmel\\CG7622; Dmel_CG7622; EG:115C2.7; L36a; L36e; M(1)1B; M(1)Bld; Rp L36; Rpl36; Vi; anon-EST:Posey274; l(1)1Bj; l(1)G0471", "gene_names_refseq": "BcDNA:AT29875; CG7622; Dmel\\CG7622; EG:115C2.7; L36a; L36e; M(1)1B; M(1)Bld; Rp L36; RpL36; Rpl36; Vi; anon-EST:Posey274; l(1)1Bj; l(1)G0471", "protein_names_uniprotkb": "Large ribosomal subunit protein eL36; 60S ribosomal protein L36; Protein minute(1)1B", "protein_names_refseq": "CG7622-PE; Minute(1)1B; Minute(1)Blond; RpL36-PE; minute; ribosomal protein L36, isoform E; viability", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7622); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 14, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "Component of the large ribosomal subunit., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RVC6;Q0KHX6;Q9W5E5", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P49630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49735-1", "uniprot_id": "MCM2_DROME", "mass": 100415.0, "length": 887, "protein_name": "DNA replication licensing factor Mcm2", "gene_name": "Mcm2", "organism": "Fruit fly", "refseq_name": "minichromosome maintenance 2", "refseq_ac": "NP_477121", "gene_names_uniprotkb": "Mcm2; CG7538", "gene_names_refseq": "CG7538; DmMCM2; DmMcm2; DmeMCM2; Dmel\\CG7538; MCM2-7; MCM2_DROME; MCM2; McM2; Mcm2-7; Mcm2; PCR3; dMCM2; dMcm2; l(3)rL074; mcm2-7; mcm2", "protein_names_uniprotkb": "DNA replication licensing factor Mcm2; 3.6.4.12; DmMCM2; Minichromosome maintenance 2 protein", "protein_names_refseq": "CG7538-PA; Mcm2-PA; minichromosome maintenance 2", "tax_id": 7227, "disease": "autosomal dominant nonsyndromic deafness 70 (Disease Ontology:DOID:0110592); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dme:Dmel_CG7538); (R-DME-176187); (R-DME-68867); (R-DME-68949); (R-DME-68962); (R-DME-69052)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10731132;11854416;12537569;12537572;12808023;16798881;17372656;18327897;20122406;25451925;7622035", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VHU2", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;2.7.11.22;2.7.11.23;2.7.7.7;3.1.11.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;2.7.7.-;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0051301 cell division;GO:0006260 DNA replication;GO:0030261 chromosome condensation;GO:1902975 mitotic DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49963-1", "uniprot_id": "SRP19_DROME", "mass": 18395.0, "length": 160, "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "Srp19", "organism": "Fruit fly", "refseq_name": "signal recognition particle 19", "refseq_ac": "NP_477135", "gene_names_uniprotkb": "Srp19; CG4457", "gene_names_refseq": "CG4457; Dmel\\CG4457; SRP19; Srp19; srp19", "protein_names_uniprotkb": "Signal recognition particle 19 kDa protein; SRP19", "protein_names_refseq": "CG4457-PA; Srp19-PA; signal recognition particle 19 kD protein; signal recognition particle 19; signal recognition particle protein 19", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4457); (R-DME-1799339)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9426007", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (By similarity). Mediates binding of Srp54 to the SRP complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VS53", "ec_number_list": "", "go_molecular_function": "GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005730 nucleolus", "go_biological_process": "GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49963-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50535-1", "uniprot_id": "MSL1_DROME", "mass": 117503.0, "length": 1039, "protein_name": "Protein male-specific lethal-1", "gene_name": "msl-1", "organism": "Fruit fly", "refseq_name": "male-specific lethal 1, isoform B", "refseq_ac": "NP_001286054", "gene_names_uniprotkb": "msl-1; CG10385; Dmel\\CG10385; Dmel_CG10385; MSL-1; MSL1; MSL; Msl 1-3; Msl-1; Msl1; i94; km(2)B; kmB; mls-1; msl1; msl", "gene_names_refseq": "CG10385; Dmel\\CG10385; MSL-1; MSL1; MSL; Msl 1-3; Msl-1; Msl1; i94; km(2)B; kmB; mls-1; msl-1; msl1; msl", "protein_names_uniprotkb": "Protein male-specific lethal-1", "protein_names_refseq": "CG10385-PB; Male-Specific lethal 1; killer-of-males-B; male specifc lethal; male specific lethal 1; male-specific lethal 1, isoform B; males specific lethal 1; msl-1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10385); (R-DME-3214847)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10679323;10731132;11014199;12537568;12537572;12537573;12537574;12653959;16110336;16543150;17569856;17569867;18510926;21726816;23084834;25589440;26109356;26109357;27183194;32502394;34426916;7781064;8325488", "class_list": "", "function": "Component of the male-specific lethal (MSL) histone acetyltransferase complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation) (PubMed:21726816, PubMed:7781064). The MSL complex specifically associates with the single X chromosome in males and mediates formation of H4K16ac, promoting a two-fold activation of X chromosome (PubMed:16543150, PubMed:18510926). In complex with msl-2, promotes ubiquitination of histone H2B (PubMed:21726816). In addition to its role in dosage compensation in males, regulates the activity of gene promoters: acts together with Cdk7 to promote phosphorylation of 'Ser-5' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit Polr2A (PubMed:27183194)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZAP1;Q9VJ66", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005694 chromosome;GO:0000228 nuclear chromosome;GO:0072487 MSL complex;GO:0000805 X chromosome;GO:0046536 dosage compensation complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006325 chromatin organization;GO:0009047 dosage compensation by hyperactivation of X chromosome", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P50535-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51406-1", "uniprot_id": "BYS_DROME", "mass": 49967.0, "length": 436, "protein_name": "Bystin", "gene_name": "bys", "organism": "Fruit fly", "refseq_name": "by S6", "refseq_ac": "NP_511074", "gene_names_uniprotkb": "bys; CG1430", "gene_names_refseq": "CG1430; Dmel\\CG1430; bys", "protein_names_uniprotkb": "Bystin; Protein bys", "protein_names_refseq": "CG1430-PA; by S6; bys-PA; bystin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1430)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;8384310", "class_list": "", "function": "Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W3N3", "ec_number_list": "", "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51406-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52485-1", "uniprot_id": "UBCD2_DROME", "mass": 24435.0, "length": 232, "protein_name": "Ubiquitin-conjugating enzyme E2-24 kDa", "gene_name": "Ubc2", "organism": "Fruit fly", "refseq_name": "ubiquitin conjugating enzyme 2, isoform C", "refseq_ac": "NP_001260362", "gene_names_uniprotkb": "Ubc2; CG6720; UbcD2", "gene_names_refseq": "CG6720; Dmel\\CG6720; UBCD2; Ubc2; UbcD2; l(2)k13206; ubcD2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2-24 kDa; 2.3.2.23; E2 ubiquitin-conjugating enzyme 2; Ubiquitin carrier protein; Ubiquitin-protein ligase", "protein_names_refseq": "CG6720-PC; Ubc2-PC; ubiquitin conjugating enzyme 2, isoform C; ubiquitin conjugating enzyme 2", "tax_id": 7227, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG6720); (R-DME-141430); (R-DME-174048); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-176407); (R-DME-176408); (R-DME-176409); (R-DME-176412); (R-DME-179409); (R-DME-2467813); (R-DME-2559582); (R-DME-68867); (R-DME-69017); (R-DME-8866652); (R-DME-983168)", "pathway_count": 18, "publication_count": 3, "publication_id_list": "10731132;12537572;8576256", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VKQ4", "ec_number_list": "2.3.2.27;2.3.2.25;2.3.2.23;2.1.1.356;2.1.1.367;2.1.1.371;2.1.1.355;2.1.1.369;2.1.1.368;2.3.2.31;2.7.11.22;2.7.11.23;2.7.11.21;3.4.19.-;5.6.1.5;6.2.1.64;2.3.2.26;2.7.11.1;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0019915 lipid storage", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P52485-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52905-1", "uniprot_id": "TRYI_DROME", "mass": 26612.0, "length": 252, "protein_name": "Trypsin iota", "gene_name": "iotaTry", "organism": "Fruit fly", "refseq_name": "iotaTrypsin", "refseq_ac": "NP_523695", "gene_names_uniprotkb": "iotaTry; CG7754; Tryiota", "gene_names_refseq": "143775_at; CG7754; Dmel\\CG7754; IotaTry; SP129; iotaTry", "protein_names_uniprotkb": "Trypsin iota; 3.4.21.4", "protein_names_refseq": "CG7754-PA; iotaTry-PA; iotaTrypsin; trypsin iota", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7754)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540Z6;Q9V5Y6", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P52905-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53034-1", "uniprot_id": "RFC2_DROME", "mass": 37173.0, "length": 331, "protein_name": "Replication factor C subunit 2", "gene_name": "RfC4", "organism": "Fruit fly", "refseq_name": "replication factor C subunit 4", "refseq_ac": "NP_523915", "gene_names_uniprotkb": "RfC4; CG14999; RfC40", "gene_names_refseq": "154910_at; BEST:GH24992; CG14999; DmRFC4; Dmel\\CG14999; RFC40; RfC2; RfC40; RfC4; Rfc40; Rfc4; l(3)64Ai; l(3)A1; l(3)Rfc4; l(3)SG13; l(3)SH17; l(3)dsl-1; l(3)dsl1; l(3)e20; l(3)rfc40; rfc40; rfc4; rfc[40]; rfc", "protein_names_uniprotkb": "Replication factor C subunit 2; A1 40 kDa subunit; Activator 1 40 kDa subunit; Activator 1 subunit 2; DmRfc4; RF-C 40 kDa subunit; RFC40; Replication factor C 40 kDa subunit; Replication factor C subunit 4", "protein_names_refseq": "CG14999-PA; Replication-factor-C 40kD subunit; RfC4-PA; lethal (3) SG13; replication factor C subunit 4", "tax_id": 7227, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (dme:Dmel_CG14999); (R-DME-110312); (R-DME-110314); (R-DME-110320); (R-DME-174411); (R-DME-176187); (R-DME-5651801); (R-DME-5655862); (R-DME-5656121); (R-DME-5656169); (R-DME-5696397); (R-DME-5696400); (R-DME-6782135); (R-DME-6782210); (R-DME-69091)", "pathway_count": 15, "publication_count": 5, "publication_id_list": "10731132;11438670;12537569;12537572;7789770", "class_list": "", "function": "The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VZH9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006272 leading strand elongation;GO:0006281 DNA repair;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54192-1", "uniprot_id": "OB19D_DROME", "mass": 16782.0, "length": 150, "protein_name": "General odorant-binding protein 19d", "gene_name": "Obp19d", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 19d, isoform A", "refseq_ac": "NP_523421", "gene_names_uniprotkb": "Obp19d; CG1668; Pbprp2", "gene_names_refseq": "19d; BcDNA:HL07789; BcDNA:RH68082; CG1668; DmelObp19d; Dmel\\CG1668; OBP19d; Obp19d; PB-PRP2; PBP2; PBPRP-2; PBPRP2; Pbprp2; pbprp-2; pbprp2", "protein_names_uniprotkb": "General odorant-binding protein 19d; Odorant-binding protein 19d; PBPRP-2; Pheromone-binding protein-related protein 2", "protein_names_refseq": "CG1668-PA; Obp19d-PA; Odorant-binding protein 19d, isoform A; Pheromone-binding protein-related protein 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1668)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;7545907", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4T7;B3DMN4;Q8MYT1;Q9VR97", "ec_number_list": "", "go_molecular_function": "GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54192-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54631-1", "uniprot_id": "SCW_DROME", "mass": 45891.0, "length": 400, "protein_name": "Protein screw", "gene_name": "scw", "organism": "Fruit fly", "refseq_name": "screw, isoform B", "refseq_ac": "NP_001286088", "gene_names_uniprotkb": "scw; BcDNA:LD30945; CG31695; DmSCW; Dmel\\CG31695; Dmel_CG31695; SCW; Scw; l(2)37Ff; l(2)IG76; mor2", "gene_names_refseq": "BcDNA:LD30945; CG31695; DmSCW; Dmel\\CG31695; SCW; Scw; l(2)37Ff; l(2)IG76; mor2; scw", "protein_names_uniprotkb": "Protein screw", "protein_names_refseq": "CG31695-PB; morphological defects 2; screw, isoform B; screw; scw-PB", "tax_id": 7227, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); prostate cancer (Disease Ontology:DOID:10283); pyelonephritis (Disease Ontology:DOID:11400); acute kidney tubular necrosis (Disease Ontology:DOID:12556); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (dme:Dmel_CG31695); (R-DME-114608)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7958918", "class_list": "", "function": "Part of the signal that specifies dorsal cell fates in the embryo. Acts together with dpp., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8INV8", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0030509 BMP signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0008406 gonad development;GO:0007502 digestive tract mesoderm development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P54631-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P55841-1", "uniprot_id": "RL14_DROME", "mass": 19174.0, "length": 166, "protein_name": "Large ribosomal subunit protein eL14", "gene_name": "RpL14", "organism": "Fruit fly", "refseq_name": "ribosomal protein L14", "refseq_ac": "NP_523975", "gene_names_uniprotkb": "RpL14; CG6253", "gene_names_refseq": "CG6253; Dmel\\CG6253; L14e; L14; M(3)66D; M(3)66; M(3); M66D; RPL14; Rp L14; RpL14; anon-EST:Posey193U; anon-EST:Posey6; rpl14", "protein_names_uniprotkb": "Large ribosomal subunit protein eL14; 60S ribosomal protein L14", "protein_names_refseq": "60 S ribosomal protein L14; CG6253-PA; Minute(3)66D; RpL14-PA; minute (3)66D; ribosomal protein L14", "tax_id": 7227, "disease": "congenital heart disease (Disease Ontology:DOID:1682); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dme:Dmel_CG6253); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "10731132;12537572;23636399", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VSM3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P55841-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56079-1", "uniprot_id": "CDS_DROME", "mass": 51511.0, "length": 447, "protein_name": "Phosphatidate cytidylyltransferase, photoreceptor-specific", "gene_name": "Cds", "organism": "Fruit fly", "refseq_name": "CDP-diacylglycerol synthase, isoform B", "refseq_ac": "NP_001286976", "gene_names_uniprotkb": "Cds; CDS; CG7962; CdsA; Dmel\\CG7962; Dmel_CG7962; cdsA; cds; eye-CDS; eye-cds", "gene_names_refseq": "CDS; CG7962; CdsA; Cds; Dmel\\CG7962; cdsA; cds; eye-CDS; eye-cds", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase, photoreceptor-specific; 2.7.7.41; CDP-DAG synthase; CDP-DG synthase; CDP-diacylglycerol synthase; CDP-diglyceride pyrophosphorylase; CDP-diglyceride synthase; CDS; CTP:phosphatidate cytidylyltransferase", "protein_names_refseq": "CDP diglyceride synthetase; CDP-DAG synthase; CDP-diacylglycerol synthase, isoform B; CDP-diacylglycerol synthetase; CDS-diacylglycerol synthase; CG7962-PB; Cds-PB; cytidine diphosphate (CDP)-DAG synthase; diacyl-glycerol-synthetase; winded", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG7962); (R-DME-1483148); (R-DME-1483226)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;24603715;25589440;26109356;26109357;26791243;7816135", "class_list": "", "function": "Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG) (PubMed:24603715, PubMed:7816135). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction (PubMed:7816135). In the salivary glands and possibly other adipose tissues, function is essential for regulating cell growth and neutral lipid storage by coordinating PtdIns metabolism and insulin pathway activity (PubMed:24603715). Acts by positively regulating activity of the insulin pathway through synthesis of PtdIns, and in turn the insulin pathway up-regulates the synthesis of CdsA (PubMed:24603715). This CdsA-insulin positive feedback loop may be one of the mechanisms for coordinating cell growth and fat storage; switching to fat storage when cells reach homeostasis or converting from growth to fat storage under nutrient-poor conditions (PubMed:24603715). Required for spermatid individualization by regulating lipid compositions and lipid-mediated signaling during spermatogenesis (PubMed:26791243)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VSE0", "ec_number_list": "2.7.7.41", "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0007601 visual perception;GO:0010513 positive regulation of phosphatidylinositol biosynthetic process;GO:0010883 regulation of lipid storage;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P56079-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56538-1", "uniprot_id": "IF6_DROME", "mass": 26494.0, "length": 245, "protein_name": "Eukaryotic translation initiation factor 6", "gene_name": "eIF6", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 6", "refseq_ac": "NP_659573", "gene_names_uniprotkb": "eIF6; CG17611", "gene_names_refseq": "CG17611; DeIF6; Dmel\\CG17611; EIF6; anon-WO0172774.153; anon-WO0172774.155; eIF6; eif6; elF6; l(2)k13214", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 6; eIF-6", "protein_names_refseq": "CG17611-PA; eIF6-PA; eukaryotic translation initiation factor 6", "tax_id": 7227, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG17611)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MLQ6;Q9W1I5", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0006413 translational initiation;GO:0000460 maturation of 5.8S rRNA;GO:0042256 cytosolic ribosome assembly;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56538-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61855-1", "uniprot_id": "AKH_DROME", "mass": 8843.0, "length": 79, "protein_name": "Adipokinetic hormone", "gene_name": "Akh", "organism": "Fruit fly", "refseq_name": "adipokinetic hormone", "refseq_ac": "NP_523918", "gene_names_uniprotkb": "Akh; CG1171", "gene_names_refseq": "ADKH; AKH1; AKH; Akh; CG1171; Dmel\\CG1171; Drm-AKH; DrmAKH; Hrth; akh; dAKH; dAkh", "protein_names_uniprotkb": "Adipokinetic hormone; HRTH; Hypertrehalosaemic hormone; dAKH", "protein_names_refseq": "Akh-PA; CG1171-PA; Hypertrehaloseaemic-hormone; adipo- kinetic hormone; adipokinetic hormone-like; adipokinetic hormone", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1171)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12171930;12537572;2117437;7664975", "class_list": "", "function": "Probably causes a marked increase in hemolymph carbohydrate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17975;Q9VZH6", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0097005 adipokinetic hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0033500 carbohydrate homeostasis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0010898 positive regulation of triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P61855-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81829-1", "uniprot_id": "LCK_DROME", "mass": 18277.0, "length": 160, "protein_name": "Leucokinin", "gene_name": "Lk", "organism": "Fruit fly", "refseq_name": "leucokinin", "refseq_ac": "NP_524893", "gene_names_uniprotkb": "Lk; CG13480; pp", "gene_names_refseq": "CG13480; DLK; Dmel\\CG13480; Drm-KIN; Kinin; LCK; LK; Leuk; Lk; kinin; leucokinin; leuc; leukokinin; lk; pp", "protein_names_uniprotkb": "Leucokinin; DLK", "protein_names_refseq": "CG13480-PA; Leucokinin-1; Leucokinin-like; Lk-PA; drosokinin; kinin; leucokinin precursor; leucokinin; leukokinin neuropeptide; myokinin-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13480)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10574744;10731132;12171930;12537572", "class_list": "", "function": "Acts through intracellular calcium in Malpighian tubule stellate cells to raise chloride conductance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3G8;Q9U4A5;Q9VUF4", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0008613 diuretic hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0007589 body fluid secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P81829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81909-1", "uniprot_id": "OR22A_DROME", "mass": 46754.0, "length": 397, "protein_name": "Odorant receptor 22a", "gene_name": "Or22a", "organism": "Fruit fly", "refseq_name": "odorant receptor 22a", "refseq_ac": "NP_523453", "gene_names_uniprotkb": "Or22a; AN11; CG12193; DOR22A.1; Or22A.1; dor53", "gene_names_refseq": "22A.1; 22a; AN11; CG12193; DOR22A.1; DOR22a; DOR53; DmOr22a; Dmel Or22a; Dmel22a; Dmel\\CG12193; Dor53; OR22a; Or22A.1; Or22a/b; Or22a; Or22; Or53; dOr22a; dor53", "protein_names_uniprotkb": "Odorant receptor 22a", "protein_names_refseq": "CG12193-PA; Or22a-PA; odorant receptor 22a; odorant receptor 53; olfactory receptor 22A.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12193)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;12537572;12628173;15592462;16402857;16615896;16919756;17103386;18408711;18922763;22038943;23196131;23315042", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Involved in the behavioral responses ethyl butyrate and to esters in more general. Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7VC05;B7VC07;B7VC09;B7VC11;B7VC21;B7VC27;B7VC29;B7VC75;B7VC77;B7VCA5;Q9U6X7", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0099094 ligand-gated monoatomic cation channel activity;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0032590 dendrite membrane;GO:0071683 sensory dendrite", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007165 signal transduction;GO:0098655 monoatomic cation transmembrane transport;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P81909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81928-1", "uniprot_id": "TIDC1_DROME", "mass": 29182.0, "length": 261, "protein_name": "Complex I assembly factor TIMMDC1, mitochondrial", "gene_name": "Timmdc1", "organism": "Fruit fly", "refseq_name": "upstream of RpII140, isoform B", "refseq_ac": "NP_001262561", "gene_names_uniprotkb": "Timmdc1; 140up; CG9852", "gene_names_refseq": "140up; CG9852; DmRP140-upstream; DmRP140up; Dmel\\CG9852; dTIMMDC1; l(3)88Ba; l(3)Z6", "protein_names_uniprotkb": "Complex I assembly factor TIMMDC1, mitochondrial; RPII140-upstream gene protein; Translocase of inner mitochondrial membrane domain-containing protein 1; dTIMMDC1", "protein_names_refseq": "140up-PB; CG9852-PB; upstream of RpII140, isoform B", "tax_id": 7227, "disease": "nuclear type mitochondrial complex I deficiency 31 (Disease Ontology:DOID:0112071)", "pathway": " (dme:Dmel_CG9852); (R-DME-6799198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;1905256;34386730", "class_list": "", "function": "Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). Essential for viability (PubMed:1905256)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KFZ0;Q9VFM8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P81928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82706-1", "uniprot_id": "BM01_DROME", "mass": 4670.0, "length": 45, "protein_name": "Bomanin Short 1", "gene_name": "BomS1", "organism": "Fruit fly", "refseq_name": "bomanin short 1", "refseq_ac": "NP_611319", "gene_names_uniprotkb": "BomS1; Bom1; CG18108; IM1", "gene_names_refseq": "BcDNA:RH08745; Bom1; BomS1; CG18108; DIM 1; DIM-1; DIM1; Dmel\\CG18108; IM-1; IM1; IM2-like", "protein_names_uniprotkb": "Bomanin Short 1; Bomanin-1; DIM-1; Immune-induced peptide 1", "protein_names_refseq": "BomS1-PA; CG18108-PA; Immune-induced peptide 1 precursor; bomanin 1; bomanin S1; bomanin short 1; immune induced molecule 1; immune-induced molecule 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18108)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;25915418;29920489;9736738", "class_list": "", "function": "Secreted immune-induced peptide induced by Toll signaling (PubMed:25915418, PubMed:29920489, PubMed:9736738). Has a role in resistance to bacterial and fungal infections (PubMed:25915418, PubMed:29920489, PubMed:9736738). Has no activity against the fungus C.glabrata in vitro (PubMed:29920489)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V8F6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0045087 innate immune response;GO:0009617 response to bacterium;GO:0010046 response to mycotoxin", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P82706-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82890-1", "uniprot_id": "PPAC1_DROME", "mass": 17556.0, "length": 155, "protein_name": "Low molecular weight phosphotyrosine protein phosphatase 1", "gene_name": "primo-1", "organism": "Fruit fly", "refseq_name": "primo-1, isoform B", "refseq_ac": "NP_001027186", "gene_names_uniprotkb": "primo-1; CG31311", "gene_names_refseq": "BEO2; CG31311; CG33748; CG9599; Dmel\\CG33748; LMW-PTP; Primo-1; primo-1; primo", "protein_names_uniprotkb": "Low molecular weight phosphotyrosine protein phosphatase 1; 3.1.3.2; 3.1.3.48; Low molecular weight cytosolic acid phosphatase 1; PTPase 1", "protein_names_refseq": "CG33748-PB; primo-1, isoform B; primo-1-PB", "tax_id": 7227, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); conduct disorder (Disease Ontology:DOID:12995); coronary artery disease (Disease Ontology:DOID:3393); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG33748)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10675607;10731132;12537572", "class_list": "", "function": "Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2V3;Q9VFR9", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.-;3.1.3.2;3.1.3.1;3.1.3.27", "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P82890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82910-1", "uniprot_id": "HSP70_DROME", "mass": 70160.0, "length": 642, "protein_name": "Heat shock 70 kDa protein Aa", "gene_name": "Hsp70Aa", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 Aa", "refseq_ac": "NP_731651", "gene_names_uniprotkb": "Hsp70Aa; CG31366; Hsp70A", "gene_names_refseq": "87A hsp70; 87A7 hsp70; 87A; CG31366; Dm-hsp70; DmHSP70AA; Dmel\\CG31366; HSP 70; HSP70cA1; HSP70; Hsp 70; Hsp-70Aa; Hsp-70; Hsp70Aa; Hsp70A; Hsp70a; Hsp70; dHSP70; dHsp70; dhsp70Aa; dhsp70; hs70; hsp 70; hsp-70; hsp70 87A; hsp70 Aa; hsp70(87A); hsp70Aa; hsp70A; hsp70a; hsp70", "protein_names_uniprotkb": "Heat shock 70 kDa protein Aa; HSP70-87A7; Heat shock protein 70 Aa", "protein_names_refseq": "70 kDa heat shock protein, cytosolic A 1; 87A locus; CG31366-PA; Heat-shock-protein-70Aa; Hsp70Aa-PA; heat shock 70; heat shock protein 70 Aa; heat shock protein-70; heat-shock protein 70; hsp70 87A; protein 70", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18743); (dme:Dmel_CG31366)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;11493638;11965431;12537569;12537572;18344983;18614012", "class_list": "", "function": "Stress-response chaperone protein that prevents toxic aggregation of proteins., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BI85;Q8MT04;Q95NG7;Q9BIS5", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0009408 response to heat;GO:0042026 protein refolding;GO:0035080 heat shock-mediated polytene chromosome puffing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P82910-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82982-1", "uniprot_id": "OR65A_DROME", "mass": 48730.0, "length": 417, "protein_name": "Odorant receptor 65a", "gene_name": "Or65a", "organism": "Fruit fly", "refseq_name": "odorant receptor 65a", "refseq_ac": "NP_729161", "gene_names_uniprotkb": "Or65a; CG32401", "gene_names_refseq": "65a; CG32401; DOR66; Dmel\\CG32401; LU27.2; OR65a; Or65a; or65a", "protein_names_uniprotkb": "Odorant receptor 65a", "protein_names_refseq": "CG32401-PA; Or65a-PA; odorant receptor 65a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32401)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10943836;12537572;16615896;21685916", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in olfactory communication for modulating aggression through the sensing of the male-specific pheromone 11-cis-vaccenyl acetate (cVA). Although acute exposure to cVA elicites aggression through Or67d olfactory receptor neurons (ORNs), chronic cVA exposure reduces aggression through Or65a ORNs. Moreover, cVA leads to generalized learning with mated females. It is a major component of the male cuticular hydrocarbon profile, but it is not found on virgin females. During copulation, cVA is transferred to the female in ejaculate along with sperm and peptides that decrease her sexual receptivity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P82982-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P82984-1", "uniprot_id": "OR65C_DROME", "mass": 48236.0, "length": 410, "protein_name": "Putative odorant receptor 65c", "gene_name": "Or65c", "organism": "Fruit fly", "refseq_name": "odorant receptor 65c", "refseq_ac": "NP_729163", "gene_names_uniprotkb": "Or65c; CG32403", "gene_names_refseq": "65c; CG32403; DOR65; Dmel\\CG32403; LU27.3; OR65c; Or65c", "protein_names_uniprotkb": "Putative odorant receptor 65c", "protein_names_refseq": "CG32403-PA; Or65c-PA; odorant receptor 65c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32403)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83097-1", "uniprot_id": "WSCK_DROME", "mass": 88520.0, "length": 791, "protein_name": "Putative inactive tyrosine-protein kinase Wsck", "gene_name": "Wsck", "organism": "Fruit fly", "refseq_name": "wsck", "refseq_ac": "NP_733018", "gene_names_uniprotkb": "Wsck; CG31127", "gene_names_refseq": "BcDNA:LD25626; BcDNA:SD05152; CG31127; Dmel\\CG31127; WSCK; Wsck", "protein_names_uniprotkb": "Putative inactive tyrosine-protein kinase Wsck", "protein_names_refseq": "CG31127-PA; Wsck-PA; wsck", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31127)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Probably lacks tyrosine-protein kinase activity., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8I0H1;Q95TS7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P83097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83103-1", "uniprot_id": "HASP_DROME", "mass": 65323.0, "length": 566, "protein_name": "Serine/threonine-protein kinase haspin homolog", "gene_name": "Haspin", "organism": "Fruit fly", "refseq_name": "haspin", "refseq_ac": "NP_001015349", "gene_names_uniprotkb": "Haspin; CG40080", "gene_names_refseq": "BcDNA:LD07633; CG40080; Dmel\\CG40080; HASPIN; Haspin; haspin", "protein_names_uniprotkb": "Serine/threonine-protein kinase haspin homolog; 2.7.11.1", "protein_names_refseq": "CG40080-PA; Haspin-PA; haspin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG40080)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;32750047;40245499", "class_list": "", "function": "Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-4' (H3T3ph) during mitosis and interphase (PubMed:32750047). Function is essential for chromosome organization during mitosis and genome organization in interphase cells, thus playing a functional role in gene regulation (PubMed:32750047). During mitosis, may act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity). During interphase, associates with the cohesion complex and mediates pds5 binding to chromatin to ensure correct sister chromatid cohesion, chromatin organization, and also functions with Pds5-cohesin to modify Polycomb-dependent homeotic transformations (PubMed:32750047). Function during interphase is required for insulator activity, nuclear compaction, heterochromatin-induced position-effect variegation and PcG-mediated pairing-sensitive silencing (PubMed:32750047)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7PLN2", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;5.6.1.8;2.7.11.11;2.7.11.23;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;2.7.11.39", "go_molecular_function": "GO:0005524 ATP binding;GO:0072354 histone H3T3 kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0000785 chromatin;GO:0005652 nuclear lamina", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043687 post-translational protein modification;GO:0034093 positive regulation of maintenance of sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P83103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83297-1", "uniprot_id": "GR64F_DROME", "mass": 54576.0, "length": 469, "protein_name": "Gustatory receptor for sugar taste 64f", "gene_name": "Gr64f", "organism": "Fruit fly", "refseq_name": "gustatory receptor 64f", "refseq_ac": "NP_728924", "gene_names_uniprotkb": "Gr64f; CG32255", "gene_names_refseq": "CG14988; CG32255; DmGr64f; Dmel64f; Dmel\\CG32255; GR64f; Gr64A3; Gr64f; Gr64", "protein_names_uniprotkb": "Gustatory receptor for sugar taste 64f", "protein_names_refseq": "CG32255-PA; Gr64f-PA; gustatory receptor 64A3; gustatory receptor 64f", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32255)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;11516643;12537572;14608037;17715294;19026541;23418550;23850280", "class_list": "", "function": "One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64a to detect sucrose, maltose, and glucose., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VZJ5", "ec_number_list": "", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0033041 sweet taste receptor activity;GO:0008527 taste receptor activity;GO:0170023 ionotropic sweet taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste;GO:0050912 detection of chemical stimulus involved in sensory perception of taste;GO:0050916 sensory perception of sweet taste", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P83297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83548-1", "uniprot_id": "VNNL3_DROME", "mass": 59133.0, "length": 523, "protein_name": "Vanin-like protein 3", "gene_name": "CG32750", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_727067", "gene_names_uniprotkb": "CG32750", "gene_names_refseq": "CG32750; CG3648; Dmel\\CG32750", "protein_names_uniprotkb": "Vanin-like protein 3; 3.5.1.-", "protein_names_refseq": "CG32750-PA; pantetheine hydrolase; uncharacterized protein", "tax_id": 7227, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); biotinidase deficiency (Disease Ontology:DOID:856)", "pathway": " (dme:Dmel_CG32750)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;25387828", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D8FT28", "ec_number_list": "", "go_molecular_function": "GO:0017159 pantetheine hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P83548-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83967-1", "uniprot_id": "ACT6_DROME", "mass": 41700.0, "length": 376, "protein_name": "Actin, indirect flight muscle", "gene_name": "Act88F", "organism": "Fruit fly", "refseq_name": "actin 88F", "refseq_ac": "NP_524367", "gene_names_uniprotkb": "Act88F; CG5178", "gene_names_refseq": "ACT88F; Act(88F); Act88-F; Act88F; Act88f; Actin88F; Actin; ArpD; CG5178; Dmel\\CG5178; E; Ifm(3)7; P83967; act 88F; act88F; actin; rsd", "protein_names_uniprotkb": "Actin, indirect flight muscle; 3.6.4.-; Actin-88F", "protein_names_refseq": "88F actin; Act88F-PA; CG5178-PA; F-actin; actin 88F; actin88F; arthrin", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); Baraitser-Winter syndrome 2 (Disease Ontology:DOID:0081113); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); nemaline myopathy 3 (Disease Ontology:DOID:0110927); intestinal atresia (Disease Ontology:DOID:10486); hand, foot and mouth disease (Disease Ontology:DOID:10881); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); thrombocytopenia (Disease Ontology:DOID:1588); nemaline myopathy (Disease Ontology:DOID:3191); temporal lobe epilepsy (Disease Ontology:DOID:3328); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (dme:Dmel_CG5178); (R-DME-114608); (R-DME-9035034)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;12537572;17353360;22116028;6263481;6405041;6488317", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Required for proper formation of indirect flight muscle (IFM) myofibrils., [UniProtKB]; Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02575;P45893;Q9VF62", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.5.2;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;1.15.1.1;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.1.3.95;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0005865 striated muscle thin filament;GO:0030018 Z disc;GO:0030016 myofibril", "go_biological_process": "GO:0000281 mitotic cytokinesis;GO:0030239 myofibril assembly;GO:0071689 muscle thin filament assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P83967-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84051-1", "uniprot_id": "H2A_DROME", "mass": 13363.0, "length": 124, "protein_name": "Histone H2A", "gene_name": "His2A:CG31618; His2A:CG33808; His2A:CG33814; His2A:CG33817; His2A:CG33820; His2A:CG33823; His2A:CG33826; His2A:CG33829; His2A:CG33832; His2A:CG33835; His2A:CG33838; His2A:CG33841; His2A:CG33844; His2A:CG33847; His2A:CG33850; His2A:CG33862; His2A:CG33865; His2A", "organism": "Fruit fly", "refseq_name": "histone H2A", "refseq_ac": "NP_001027292", "gene_names_uniprotkb": "His2A:CG31618; His2A:CG33808; His2A:CG33814; His2A:CG33817; His2A:CG33820; His2A:CG33823; His2A:CG33826; His2A:CG33829; His2A:CG33832; His2A:CG33835; His2A:CG33838; His2A:CG33841; His2A:CG33844; His2A:CG33847; His2A:CG33850; His2A:CG33862; His2A:CG33865; His2A; CG31618; CG33808; CG33814; CG33817; CG33820; CG33823; CG33826; CG33829; CG33832; CG33835; CG33838; CG33841; CG33844; CG33847; CG33850; CG33862; CG33865; H2a", "gene_names_refseq": "CG33808; Dmel\\CG33808; His2A:CG33808", "protein_names_uniprotkb": "Histone H2A", "protein_names_refseq": "CG33808-PA; His2A:CG33808-PA; histone H2A", "tax_id": 7227, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); liver benign neoplasm (Disease Ontology:DOID:916); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (dme:Dmel_CG31618); (dme:Dmel_CG33808); (dme:Dmel_CG33814); (dme:Dmel_CG33817); (dme:Dmel_CG33820); (dme:Dmel_CG33823); (dme:Dmel_CG33826); (dme:Dmel_CG33829); (dme:Dmel_CG33832); (dme:Dmel_CG33835); (dme:Dmel_CG33838); (dme:Dmel_CG33841); (dme:Dmel_CG33844); (dme:Dmel_CG33847); (dme:Dmel_CG33850); (dme:Dmel_CG33862); (dme:Dmel_CG33865)", "pathway_count": 17, "publication_count": 13, "publication_id_list": "10731132;12537572;15078818;15133681;15386022;16230526;17827147;20436459;22389435;24508391;2536150;30258054;30639226", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in recruitment of Parp1 to chromatin and regulates its activity; the N-terminal tail inhibits histone H4-dependent activation of Parp1 (PubMed:17827147, PubMed:24508391)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02267;Q4ABC7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0000786 nucleosome;GO:0005700 polytene chromosome;GO:0005704 polytene chromosome band", "go_biological_process": "GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0031507 heterochromatin formation;GO:0007526 larval somatic muscle development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P84051-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P91679-1", "uniprot_id": "PEPT1_DROME", "mass": 82245.0, "length": 743, "protein_name": "Peptide transporter family 1", "gene_name": "yin", "organism": "Fruit fly", "refseq_name": "yin, isoform A", "refseq_ac": "NP_477147", "gene_names_uniprotkb": "yin; CG2913; CG34336; CG44402; Dmel\\CG44402; Dmel_CG44402; EG:EG0002.1; OPT1; OpT1; Opt1; Yin; opt1; opt", "gene_names_refseq": "CG2913; CG34336; CG44402; Dmel\\CG44402; EG:EG0002.1; OPT1; OpT1; Opt1; Yin; opt1; opt; yin", "protein_names_uniprotkb": "Peptide transporter family 1; Oligopeptide transporter 1; Protein YIN", "protein_names_refseq": "CG44402-PA; oligopeptide transporter 1; yin, isoform A; yin-PA", "tax_id": 7227, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG44402); (R-DME-427975)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9038337;9730971", "class_list": "", "function": "Important role in absorption of dietary peptides. High-affinity transporter of alanylalanine. Dipeptide transport activity is proton dependent., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9UNA2;A9UNE6;O77281;O77282;Q7K7E7;Q7KVX8;Q8IRT2;Q95TX0;Q9TY25;Q9TY26;Q9W4P7;Q9W4P8", "ec_number_list": "", "go_molecular_function": "GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0035673 oligopeptide transmembrane transporter activity;GO:0071916 dipeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006857 oligopeptide transport;GO:0140206 dipeptide import across plasma membrane;GO:0035442 dipeptide transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P91679-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P92029-1", "uniprot_id": "DNJ60_DROME", "mass": 24780.0, "length": 217, "protein_name": "DnaJ-like protein 60", "gene_name": "DnaJ-60", "organism": "Fruit fly", "refseq_name": "DnaJ-like-60, isoform A", "refseq_ac": "NP_523840", "gene_names_uniprotkb": "DnaJ-60; CG12240; CG42567; DmJ60; Dmel\\CG42567; Dmel_CG42567; DnaJ60; anon-WO0172774.147", "gene_names_refseq": "CG12240; CG42567; DmJ60; Dmel\\CG42567; DnaJ-60; DnaJ60; anon-WO0172774.147", "protein_names_uniprotkb": "DnaJ-like protein 60", "protein_names_refseq": "CG42567-PA; DnaJ-60-PA; DnaJ-like-60, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42567)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9372188", "class_list": "", "function": "May play an important function during spermatogenesis and/or in the male genital tract., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P92029-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P92177-3", "uniprot_id": "1433E_DROME", "mass": 29799.0, "length": 262, "protein_name": "14-3-3 protein epsilon", "gene_name": "14-3-3epsilon", "organism": "Fruit fly", "refseq_name": "14-3-3epsilon, isoform A", "refseq_ac": "NP_732309", "gene_names_uniprotkb": "14-3-3epsilon; 14-3-3e; CG31196; SR3-9", "gene_names_refseq": "14-3-3 epsilon; 14-3-3-epsilon; 14-3-3-e; 14-3-30epsilon; 14-3-3EPSILON; 14-3-3epsilon; 14-3-3e; 14-3-3omicron; 14-3-3; 14.3.3 epsilon; 14.3.3; 1433epsilon; 143E_DROME; CG31196; CT24092; D14-3-3epsilon; D14-3-3e; Dmel\\CG31196; EK3-5; Eps; PAR-5; PAR5; Par-5; SR3-9; Su(Raf)3B; anon-WO0172774.141; anon-WO02059370.52; d14-3-3epsilon; e-14-3-3; eps; l(3)j2B10; par-5", "protein_names_uniprotkb": "14-3-3 protein epsilon; Suppressor of Ras1 3-9", "protein_names_refseq": "14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3ε 14-3-3epsilon, isoform A; 14-3-3epsilon-PA; CG31196-PA; Tyrosine-3-monooxygenase; suppressor of Ras85D 3-9", "tax_id": 7227, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); left ventricular noncompaction (Disease Ontology:DOID:0060480)", "pathway": " (dme:Dmel_CG31196); (R-DME-2028269); (R-DME-3371453); (R-DME-3371511); (R-DME-390098); (R-DME-432553); (R-DME-5625740); (R-DME-5628897); (R-DME-75035); (R-DME-8876198)", "pathway_count": 10, "publication_count": 31, "publication_id_list": "10731132;11430804;11440719;12122057;12432393;12442174;12447397;12537572;12563262;12944510;14759367;15952742;16096061;16319317;16410523;17372656;17418796;17889654;18256197;18593878;18815259;19330023;19733165;19900439;32022690;7481773;8596938;8600384;8938123;9159394;9674431", "class_list": "", "function": "Positively regulates Ras-mediated pathways. Acts downstream or parallel to Raf, but upstream of nuclear factors in Ras signaling. Three mutants have been isolated, that suppress the rough eye phenotype caused by mutated Ras1 (sev-Ras1 v12). Inhibits yki activity by restricting its nuclear localization. Together with pav, has a role in the inhibition of microtubule sliding during neurite outgrowth (PubMed:32022690)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IN86;Q8IN87;Q9VEA8", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0050815 phosphoserine residue binding;GO:0001223 transcription coactivator binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0007165 signal transduction;GO:0040008 regulation of growth;GO:0007346 regulation of mitotic cell cycle;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P92177-3", "record_type": "protein" }, { "uniprot_canonical_ac": "P98159-1", "uniprot_id": "NUDEL_DROME", "mass": 292492.0, "length": 2616, "protein_name": "Serine protease ndl", "gene_name": "ndl", "organism": "Fruit fly", "refseq_name": "nudel", "refseq_ac": "NP_523947", "gene_names_uniprotkb": "ndl; CG10129", "gene_names_refseq": "CG10129; Dmel\\CG10129; Ndl; SP89; mat(3)2; mel(3)5; ndl; nud", "protein_names_uniprotkb": "Serine protease ndl; 3.4.21.-; Protein nudel", "protein_names_refseq": "CG10129-PA; ndl-PA; nudel", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10129)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;18327897;20605458;7671306;9477324", "class_list": "", "function": "Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo (PubMed:7671306). A protease cascade involving ndl, gd, snk and ea results in activation of the spz Toll receptor ligand; acts upstream of gd, snk and ea and is required for proteolytic processing of gd (PubMed:20605458). Activation of ea requires activation of the ndl-gd-snk protease cascade and sulfation of a vitelline membrane component by pip (PubMed:20605458). Localized activation of the Toll receptor in the ventral region of the embryo defines cell identities along the dorsal-ventral continuum (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 25, "predicted_n_glycosites": 23, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "Q9VRX5", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0098595 perivitelline space", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0016540 protein autoprocessing;GO:0031638 zymogen activation;GO:0009950 dorsal/ventral axis specification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P98159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00805-1", "uniprot_id": "GIL_DROME", "mass": 49924.0, "length": 444, "protein_name": "Protein giant-lens", "gene_name": "aos", "organism": "Fruit fly", "refseq_name": "argos", "refseq_ac": "NP_524107", "gene_names_uniprotkb": "aos; CG4531; gil; sty", "gene_names_refseq": "Aos; Argos; CG4531; DmAos; Dmel\\CG4531; aos; arg; gil; l(3)05845; l(3)05959; l(3)j5E11; l(3)rJ472; l(3)rJ812; l(3)rQ526; rlt; sty", "protein_names_uniprotkb": "Protein giant-lens; Protein argos; Protein strawberry", "protein_names_refseq": "CG4531-PA; aos-PA; argos; giant lens; roulette; strawberry", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4531)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10200472;10731132;12537569;12537572;1286772;15329724;15879554;1606617;1628618;18500331", "class_list": "", "function": "Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQZ2;Q9VV64", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0048019 receptor antagonist activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0007601 visual perception;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0050768 negative regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q00805-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01070-1", "uniprot_id": "ESMC_DROME", "mass": 23135.0, "length": 205, "protein_name": "Enhancer of split mgamma protein", "gene_name": "E(spl)mgamma-HLH", "organism": "Fruit fly", "refseq_name": "enhancer of split mgamma, helix-loop-helix", "refseq_ac": "NP_524504", "gene_names_uniprotkb": "E(spl)mgamma-HLH; CG8333; HLHmgamma", "gene_names_refseq": "CG8333; Dm-mB; Dmel\\CG8333; E(Spl) HLH-m gamma; E(spl) m gamma; E(spl) mgamma; E(spl) mg; E(spl)-mgamma; E(spl)Mgamma; E(spl)gamma; E(spl)m-gamma; E(spl)mB; E(spl)mgamma-HLH; E(spl)mgamma; EE(spl)mgamma-HLH; Enhancer of split mgamma; HLH-mgamma; HLHMgamma; HLHmB; HLHmgamma; HlHmg; Mgamma; anon-EST:Liang-1.49; bHLHb34; clone 1.49; e(spl)mgamma; gamma; mB; mgamma; mg", "protein_names_uniprotkb": "Enhancer of split mgamma protein; E(spl)mgamma; Split locus enhancer protein mB", "protein_names_refseq": "CG8333-PA; E(spl) region transcript g; E(spl) region transcript mgamma; E(spl)mgamma-HLH-PA; enhancer of split mgamma, helix-loop-helix; enhancer of split mgamma; enhancer of split region transcript HLHmB; enhancer of split; split locus enhancer protein mB", "tax_id": 7227, "disease": "hemangiopericytoma (Disease Ontology:DOID:264); central nervous system cancer (Disease Ontology:DOID:3620)", "pathway": " (dme:Dmel_CG8333)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;10790334;12537572;1427040;1528887;15537803;22357926;24618901", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription (PubMed:24618901). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). Part of the Notch signaling pathway, plays a role in neuroblasts proliferation in embryos and larvae (PubMed:10790334, PubMed:22357926). In the larval brain, together with other self-renewal transcriptional repressors such as klu and dpn, required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP) derived from type II neuroblasts (PubMed:24618901)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q01898;Q5S4K4", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q01070-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01071-1", "uniprot_id": "ESMD_DROME", "mass": 20195.0, "length": 173, "protein_name": "Enhancer of split mdelta protein", "gene_name": "E(spl)mdelta-HLH", "organism": "Fruit fly", "refseq_name": "enhancer of split mdelta, helix-loop-helix", "refseq_ac": "NP_524503", "gene_names_uniprotkb": "E(spl)mdelta-HLH; CG8328; HLHmdelta", "gene_names_refseq": "CG8328; Dmel\\CG8328; E(Spl) HLH-m delta; E(Spl)-HLH-mdelta; E(spl) mdelta; E(spl)-mdelta; E(spl)Mdelta; E(spl)delta; E(spl)mC; E(spl)mdelta-HLH; E(spl)mdelta; HLH-mdelta; HLHMD; HLHMdelta; HLHmC; HLHmdelta; Mdelta; bHLHc14; mC; mdelta0.5; mdelta; md", "protein_names_uniprotkb": "Enhancer of split mdelta protein; E(spl)mdelta; HLH-mdelta; Split locus enhancer protein mC", "protein_names_refseq": "CG8328-PA; E(spl) region transcript mdelta; E(spl)mdelta-HLH-PA; enhancer of split mdelta, helix-loop-helix; enhancer of split region transcript HLHmC; split locus enhancer protein mC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8328)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537572;1427040;1528887;15537803;16356268;28899667;8001118", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). As part of the Notch signaling pathway, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm (PubMed:28899667)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q01897;Q4V723;Q56MT6;Q56MU1;Q56MU3;Q56MU4;Q56MU6;Q56MU8;Q56MV0;Q56MV5;Q56MV6;Q56MW2;Q56MW7;Q56MW9;Q56MX9;Q56MY0;Q56MY1;Q56N19;Q56N23;Q5S485;Q5S4A9;Q5S4K5", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007525 somatic muscle development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q01071-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01643-1", "uniprot_id": "MS84B_DROME", "mass": 6725.0, "length": 74, "protein_name": "Male-specific sperm protein Mst84Db", "gene_name": "Mst84Db", "organism": "Fruit fly", "refseq_name": "Male-specific RNA 84Db", "refseq_ac": "NP_524255", "gene_names_uniprotkb": "Mst84Db; CG17934", "gene_names_refseq": "BcDNA:AT08471; CG17934; Dmel\\CG17934; Mst ORF; Mst84Db; Mst84; Mst87D; Mstprox; Mst; NEST:bs22c06; bs22c06.y1; mst(3)gl-2", "protein_names_uniprotkb": "Male-specific sperm protein Mst84Db", "protein_names_refseq": "CG17934-PA; Male-specific RNA 84Db; Mst84Db-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17934)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;1684716", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZE2;Q9VIA1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q01643-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01645-1", "uniprot_id": "MS84D_DROME", "mass": 6840.0, "length": 72, "protein_name": "Male-specific sperm protein Mst84Dd", "gene_name": "Mst84Dd", "organism": "Fruit fly", "refseq_name": "Male-specific RNA 84Dd", "refseq_ac": "NP_524253", "gene_names_uniprotkb": "Mst84Dd; CG17935", "gene_names_refseq": "CG17935; Dmel\\CG17935; Mst ORF; Mst84Dd; Mst84; Mst87D; Mstprox; Mst; mst(3)gl-4", "protein_names_uniprotkb": "Male-specific sperm protein Mst84Dd", "protein_names_refseq": "CG17935-PA; Male-specific RNA 84Dd; Mst84Dd-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17935)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;1684716", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ31;Q4V3L2;Q9VI99", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q01645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02360-1", "uniprot_id": "FOXL1_DROME", "mass": 40635.0, "length": 365, "protein_name": "Fork head domain-containing protein L1", "gene_name": "FoxL1", "organism": "Fruit fly", "refseq_name": "forkhead box L1, isoform B", "refseq_ac": "NP_001246609", "gene_names_uniprotkb": "FoxL1; CG1132; FD2; fd64A", "gene_names_refseq": "CG1132; Dmel\\CG1132; Dmfd2; FD2; Fd64A; FoxL1; fd2; fd64A; foxL1", "protein_names_uniprotkb": "Fork head domain-containing protein L1", "protein_names_refseq": "CG1132-PB; FoxL1-PB; forkhead box L1, isoform B; forkhead domain 64A", "tax_id": 7227, "disease": "otosclerosis 11 (Disease Ontology:DOID:0060928); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185)", "pathway": " (dme:Dmel_CG1132)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;1356269;27618755", "class_list": "", "function": "Transcription factor (By similarity). Coordinates the placement and migration of various organs during embryogenesis, including the salivary glands, hemocytes, germ cells and Malpighian tubules (PubMed:27618755). Likely acts non-cell-autonomously to provide signaling cues from the mesoderm/musculature to nearby tissues (PubMed:27618755). Mediates salivary gland positioning, at least in part, through activation of the secreted signal Sema2a (PubMed:27618755)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VZK0", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02360-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02748-1", "uniprot_id": "IF4A_DROME", "mass": 45879.0, "length": 403, "protein_name": "Eukaryotic initiation factor 4A", "gene_name": "eIF4A", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 4A, isoform E", "refseq_ac": "NP_001245907", "gene_names_uniprotkb": "eIF4A; CG9075; eIF-4a; l(2L)162", "gene_names_refseq": "2439; 9075; CG9075; Dm-eIF4A; DmRH2; Dmel\\CG9075; EIF-4A; EIF-4a; EIF4A; EiF4A; Eif-4a; Eif4a; L(2L)162; Su(dpp)YE9; anon-26Aa; anon26A; deIF4A; eIF 4A; eIF-4A; eIF-4a-I; eIF-4a; eIF4A-I; eIF4AI; eIF4A; eIF4a; eiF4A; eif-4a; eif4A; eif4a; l(2)02439; l(2)162; l(2)26Ac; l(2)gdh-4; l(2)k01501; l(2L)162; pecan", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A; 3.6.4.13; ATP-dependent RNA helicase eIF4A", "protein_names_refseq": "CG9075-PE; eIF4A-PE; eukaryotic initiation factor 4A; eukaryotic translation initiation factor 4A, isoform E; translation initiation factor 4A", "tax_id": 7227, "disease": "neurodevelopmental disorder with hypotonia and speech delay (Disease Ontology:DOID:0070512)", "pathway": " (dme:Dmel_CG9075); (R-DME-156827); (R-DME-429947); (R-DME-72649); (R-DME-72662); (R-DME-72702)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10731132;10731138;12537569;12537572;15952742;18590813;19556547;8455559", "class_list": "", "function": "ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (By similarity). Binds and antagonises the bam-bgcn complex; probably prevents bam mediated translational repression of shg/E-cadherin (PubMed:19556547). Involved in germ cell formation (PubMed:18590813). Involved in germline stem cell maintenance and proliferation; prevents differentiation (PubMed:19556547)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZV9;C9QP42;Q9U9Y6;Q9VMJ8", "ec_number_list": "3.1.13.4;3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;3.6.5.3;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0046332 SMAD binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016281 eukaryotic translation initiation factor 4F complex;GO:0010494 cytoplasmic stress granule;GO:0043186 P granule", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0000278 mitotic cell cycle;GO:0006413 translational initiation;GO:0030514 negative regulation of BMP signaling pathway;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q02748-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03372-1", "uniprot_id": "HMSH_DROME", "mass": 54250.0, "length": 515, "protein_name": "Muscle segmentation homeobox", "gene_name": "Dr", "organism": "Fruit fly", "refseq_name": "drop", "refseq_ac": "NP_477324", "gene_names_uniprotkb": "Dr; CG1897; msh", "gene_names_refseq": "153515_at; 99B; CG1897; Dmel\\CG1897; Dr/Msh; Dr/msh; Dr; Msh; Msx; l(3)FA30; ltt; msh-1; msh1; msh", "protein_names_uniprotkb": "Muscle segmentation homeobox; Protein drop; Protein msh", "protein_names_refseq": "CG1897-PA; Dr-PA; Dr-distal; drop; lottchen; muscle segment homeobox; muscle specific homeobox; muscle-specific homeodomain 1", "tax_id": 7227, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); tooth agenesis (Disease Ontology:DOID:0050591); parietal foramina (Disease Ontology:DOID:0060285); craniosynostosis 2 (Disease Ontology:DOID:0061009); orofacial cleft 5 (Disease Ontology:DOID:0080399); anodontia (Disease Ontology:DOID:13714); craniosynostosis (Disease Ontology:DOID:2340); tooth and nail syndrome (Disease Ontology:DOID:6678); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (dme:Dmel_CG1897)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10731132;12537569;12537572;1673109;28716930;31010135;40245499;7556942;8887329;9486795", "class_list": "", "function": "Plays a key role in the specification of proneural and promuscular cluster formation (PubMed:8887329, PubMed:9486795). Required for the specification of dorsal and lateral muscle progenitor cells (PubMed:8887329, PubMed:9486795). Regulates development of peripheral nervous system derived from lateral neuroblasts (PubMed:28716930)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q24481;Q8T0H1;Q9VAK4", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021782 glial cell development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0007417 central nervous system development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q03372-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05192-1", "uniprot_id": "FTF1B_DROME", "mass": 87314.0, "length": 808, "protein_name": "Nuclear hormone receptor FTZ-F1 beta", "gene_name": "Hr39", "organism": "Fruit fly", "refseq_name": "hormone receptor-like in 39, isoform A", "refseq_ac": "NP_476932", "gene_names_uniprotkb": "Hr39; CG8676; FTZ-F1-beta; FTZF1-beta; NR5-beta-1; NR5B1", "gene_names_refseq": "CG8676; DHR30; DHR39/Ftz-F1beta; DHR39; Dmel\\CG8676; EP(2)2490; FTZ-F1B; FTZ-F1beta; HR39C; HR39; Hr-39; Hr39; NR5B1; betaFTZ-E1; dFTZ-F1beta; fs(2)04443; fs(2)neo8; ftz-F1beta; ftz-f1beta; i70", "protein_names_uniprotkb": "Nuclear hormone receptor FTZ-F1 beta; Nuclear hormone receptor HR39; Nuclear receptor subfamily 5 group B member 1; dHR39", "protein_names_refseq": "CG8676-PA; Hr39-PA; NR5A-class nuclear hormone receptor; fs(2)04443; fs(2)neo8; hormone receptor like in 39; hormone receptor-like in 39, isoform A; hormone receptor-like in 39", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8676)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;18327897;8164672;8382937;8479913", "class_list": "", "function": "Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0Z2;Q0E8N5;Q8INT8;Q9VID8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0035211 spermathecum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q05192-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05547-1", "uniprot_id": "PP13_DROME", "mass": 34558.0, "length": 302, "protein_name": "Serine/threonine-protein phosphatase alpha-3 isoform", "gene_name": "Pp1-13C", "organism": "Fruit fly", "refseq_name": "protein phosphatase 1 at 13C", "refseq_ac": "NP_524921", "gene_names_uniprotkb": "Pp1-13C; CG9156", "gene_names_refseq": "13C; CG9156; DmPp1-13C; Dmel\\CG9156; PP1 13C; PP1 beta13c; PP1-13C; PP13C; PP1alpha-13C; PP1alpha13C; PP1c; PP1; Pp1-13C; Pp1; pp1-13C", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase alpha-3 isoform; 3.1.3.16", "protein_names_refseq": "CG9156-PA; Pp1-13C-PA; protein phosphatase 1 13C; protein phosphatase 1 at 13C; protein phosphatase 1", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dme:Dmel_CG9156); (R-DME-538898); (R-DME-9770562)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17007873;17575052;8383037", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXW0", "ec_number_list": "2.7.7.19;3.1.3.16;3.1.3.48;2.7.11.1;2.7.7.6;3.6.4.13;3.1.3.27;3.1.27.-;3.1.3.-;3.1.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0030514 negative regulation of BMP signaling pathway;GO:0005979 regulation of glycogen biosynthetic process;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06849-1", "uniprot_id": "ARL2_DROME", "mass": 20834.0, "length": 184, "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "Arl2", "organism": "Fruit fly", "refseq_name": "ADP ribosylation factor-like 2", "refseq_ac": "NP_476886", "gene_names_uniprotkb": "Arl2; Arf84F; CG7435", "gene_names_refseq": "ARL2; Arf84D; Arf84F; Arf; Arl2; Arl84F; CG 7435; CG7435; Dm Arf84F; Dmel\\CG7435; Q06849; arl2", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 2", "protein_names_refseq": "ADP ribosylation factor 84F; ADP ribosylation factor like-2; ADP ribosylation factor-like 2; Arl2-PA; CG7435-PA; arflike-2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7435); (R-DME-9648002)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8415637", "class_list": "", "function": "GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJE0;Q95TW2;Q9VHS1", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0015630 microtubule cytoskeleton;GO:0098793 presynapse", "go_biological_process": "GO:1902850 microtubule cytoskeleton organization involved in mitosis;GO:0006457 protein folding;GO:0007269 neurotransmitter secretion;GO:0000132 establishment of mitotic spindle orientation;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q06849-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08180-1", "uniprot_id": "ICCR_DROME", "mass": 83005.0, "length": 764, "protein_name": "Irregular chiasm C-roughest protein", "gene_name": "rst", "organism": "Fruit fly", "refseq_name": "roughest, isoform B", "refseq_ac": "NP_001284835", "gene_names_uniprotkb": "rst; CG4125; CT13684; Dmel\\CG4125; Dmel_CG4125; IREE-C; Irre-C; IrreC-Rst; IrreC-rst; IrreC; IrrecC; RST; Rst; UB883; irreC-rst; irreC; irrecC-rst; irrecC; rst-irreC; rst-irrecC", "gene_names_refseq": "CG4125; CT13684; Dmel\\CG4125; IREE-C; IRREC/RST; Irre-C; IrreC-Rst; IrreC-rst; IrreC/Rst; IrreC; IrrecC; RST; Rst/IrreC; Rst; UB883; irreC-rst; irreC; irrecC-rst; rst-irreC; rst-irrecC; rst/irrecC; rst", "protein_names_uniprotkb": "Irregular chiasm C-roughest protein; Protein IRREC", "protein_names_refseq": "C-Roughest; CG4125-PB; ChiasmC-roughest; Irregular-chiasm-C; irreC-roughest; irregular chiasm C-roughest protein; irregular chiasm-C-roughest; irregular chiasmC-roughest; irregular optic chiasma C/Roughest; irregular optic chiasma C; roughest, isoform B; roughest; rst-PB", "tax_id": 7227, "disease": "nephrotic syndrome type 23 (Disease Ontology:DOID:0112266); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (dme:Dmel_CG4125); (R-DME-373753)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16322515;17569856;17569867;25589440;26109356;26109357;7503814", "class_list": "", "function": "Required for correct axonal pathway formation in the optic lobe and for programmed cell death in the developing retina., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B9EQQ5;Q2VA88;Q2VA98;Q2VAC5;Q8MQQ1;Q9W4U1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0016202 regulation of striated muscle tissue development;GO:0048749 compound eye development;GO:0098609 cell-cell adhesion;GO:0007520 myoblast fusion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q08180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0E8C8-1", "uniprot_id": "SP77B_DROME", "mass": 50163.0, "length": 450, "protein_name": "Serine protease inhibitor 77Ba", "gene_name": "Spn77Ba", "organism": "Fruit fly", "refseq_name": "serpin 77Ba, isoform C", "refseq_ac": "NP_001287128", "gene_names_uniprotkb": "Spn77Ba; CG6680", "gene_names_refseq": "CG6680; Dmel\\CG6680; Q0E8C8_DROME; Spn77Ba; l(3)77ABi; spn77Ba", "protein_names_uniprotkb": "Serine protease inhibitor 77Ba; Serpin 77Ba", "protein_names_refseq": "CG6680-PC; Spn77Ba-PC; lethal (3) 77ABi; serpin 77Ba, isoform C", "tax_id": 7227, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); thrombophilia (Disease Ontology:DOID:2452)", "pathway": " (dme:Dmel_CG6680); (R-DME-114608); (R-DME-1650814); (R-DME-381426); (R-DME-6798695); (R-DME-8939242); (R-DME-8957275); (R-DME-9855719); (R-DME-9948001)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18854145;22227521", "class_list": "", "function": "Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection (PubMed:18854145, PubMed:22227521). Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade (PubMed:18854145)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGD7;Q95SG7", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050776 regulation of immune response;GO:0045861 negative regulation of proteolysis;GO:0042438 melanin biosynthetic process;GO:0035009 negative regulation of melanization defense response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q0E8C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0E8J0-1", "uniprot_id": "Q0E8J0_DROME", "mass": 124065.0, "length": 1152, "protein_name": "MOG interacting and ectopic P-granules protein 1", "gene_name": "MEP-1", "organism": "Fruit fly", "refseq_name": "MEP-1, isoform G", "refseq_ac": "NP_001137875", "gene_names_uniprotkb": "MEP-1; CG1244; Dmel\\CG1244; Dmel_CG1244; MEP1; Mep-1; Q0E8J0_DROME; anon-EST:Liang-1.37; anon-WO0118547.584; clone 1.37; dMEP-1", "gene_names_refseq": "CG1244; Dmel\\CG1244; MEP-1; MEP1; Mep-1; Q0E8J0_DROME; anon-EST:Liang-1.37; anon-WO0118547.584; clone 1.37; dMEP-1", "protein_names_uniprotkb": "MOG interacting and ectopic P-granules protein 1; Nuclear zinc finger protein", "protein_names_refseq": "CG1244-PG; MEP-1, isoform G; MEP-1-PG", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1244)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016581 NuRD complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0141006 transposable element silencing by piRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q0E8J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0KIA2-1", "uniprot_id": "Y9801_DROME", "mass": 76765.0, "length": 709, "protein_name": "PP2C-like domain-containing protein CG9801", "gene_name": "CG9801", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": "NP_649827", "gene_names_uniprotkb": "CG9801", "gene_names_refseq": "CG9801; Dmel\\CG9801", "protein_names_uniprotkb": "PP2C-like domain-containing protein CG9801", "protein_names_refseq": "CG9801-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9801)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;17018572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXN8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0KIA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q23985-1", "uniprot_id": "DTX_DROME", "mass": 82186.0, "length": 738, "protein_name": "Protein deltex", "gene_name": "dx", "organism": "Fruit fly", "refseq_name": "deltex", "refseq_ac": "NP_511064", "gene_names_uniprotkb": "dx; CG3929", "gene_names_refseq": "CG3929; DMDELTEX; Deltex; Dlx; Dmel\\CG3929; Dx; dx", "protein_names_uniprotkb": "Protein deltex; 2.3.2.27; Probable E3 ubiquitin-protein ligase deltex; RING-type E3 ubiquitin transferase deltex", "protein_names_refseq": "CG3929-PA; deltex; dx-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3929); (R-DME-2122948)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;11719214;11861487;12537569;12537572;16271883;17989248;18327897;22162134;7671825;8150285", "class_list": "", "function": "Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway. Regulates the sorting and degradation of N/Notch via an ESCRT-III dependent endolysosomal pathway (PubMed:22162134)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9YJA9;A9YJB1;A9YJB7;B3LF71;Q86P53;Q9W3Z1", "ec_number_list": "2.3.2.27;2.3.2.26", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0005112 Notch binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005771 multivesicular body", "go_biological_process": "GO:0006897 endocytosis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q23985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24087-1", "uniprot_id": "XPF_DROME", "mass": 109519.0, "length": 961, "protein_name": "DNA repair endonuclease XPF", "gene_name": "mei-9", "organism": "Fruit fly", "refseq_name": "meiotic 9, isoform B", "refseq_ac": "NP_001284859", "gene_names_uniprotkb": "mei-9; CG3697", "gene_names_refseq": "CG3697; DhR1; DmXPF; Dmel\\CG3697; MEI-9; Mei-9; Rad1p; mei-9; mei9; mus(1)110; mus110; xpf/mei-9", "protein_names_uniprotkb": "DNA repair endonuclease XPF; 3.1.-.-; Protein meiotic 9", "protein_names_refseq": "CG3697-PB; mei-9-PB; meiotic 9, isoform B; meiotic-9", "tax_id": 7227, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); XFE progeroid syndrome (Disease Ontology:DOID:0060590); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843); xeroderma pigmentosum group F (Disease Ontology:DOID:0110848); Fanconi anemia complementation group Q (Disease Ontology:DOID:0111093); Fanconi anemia (Disease Ontology:DOID:13636); polyneuropathy due to drug (Disease Ontology:DOID:14184); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); Cockayne syndrome (Disease Ontology:DOID:2962); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG3697); (R-DME-5696395); (R-DME-5696400); (R-DME-6782135)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18957705;8647398", "class_list": "", "function": "Implicated in recombination events during meiosis, mostly in meiotic exchange. May directly resolve Holliday junctions within recombination intermediates leading to DNA exchange. Also required for the repair of mismatches within meiotic heteroduplex DNA and for nucleotide excision repair., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IHB9;Q9W4L3", "ec_number_list": "2.7.7.6;2.4.2.-;2.4.2.30;5.6.2.4;3.1.-.-;2.7.11.22;2.7.11.23;3.6.4.13;5.6.2.3;5.2.1.8;2.7.7.7;3.1.11.-;3.4.19.12", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0003684 damaged DNA binding;GO:0003697 single-stranded DNA binding;GO:0000014 single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0000110 nucleotide-excision repair factor 1 complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0016321 female meiosis chromosome segregation;GO:0006310 DNA recombination;GO:0006974 DNA damage response;GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24087-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24155-1", "uniprot_id": "TRUNK_DROME", "mass": 26348.0, "length": 226, "protein_name": "Protein trunk", "gene_name": "trk", "organism": "Fruit fly", "refseq_name": "trunk", "refseq_ac": "NP_476767", "gene_names_uniprotkb": "trk; CG5619", "gene_names_refseq": "CG5619; Dmel\\CG5619; Trk; fs(2)trunk; grk; trk", "protein_names_uniprotkb": "Protein trunk", "protein_names_refseq": "CG5619-PA; trk-PA; trunk", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5619)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;7590233", "class_list": "", "function": "Required for activity of the tor receptor, could be a ligand of tor. Involved in specifying terminal body pattern., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VL09", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0048018 receptor ligand activity;GO:0005122 torso binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0045596 negative regulation of cell differentiation;GO:0007362 terminal region determination;GO:0008293 torso signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q24155-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24178-1", "uniprot_id": "PSA72_DROME", "mass": 27940.0, "length": 249, "protein_name": "Proteasome subunit alpha type-7-1A", "gene_name": "Prosalpha4T1", "organism": "Fruit fly", "refseq_name": "proteasome alpha4 subunit, Testis-specific 1", "refseq_ac": "NP_650910", "gene_names_uniprotkb": "Prosalpha4T1; CG17268; Pros28.1A", "gene_names_refseq": "CG17268; Dmel\\CG17268; Pros28.1A; Pros28.2; Prosalpha4T1; a4-t1; alpha4T1; alpha4t1_dm; alpha4t1; dalpha7; pros28.1A", "protein_names_uniprotkb": "Proteasome subunit alpha type-7-1A; Testis-specific alpha4-t1 proteasome subunit; Testis-specific proteasome 28 kDa subunit 1A", "protein_names_refseq": "20s proteasome; CG17268-PA; Pros28.1A; Prosalpha4T1-PA; proteasome 28kD subunit 1A; proteasome 28kD subunit 2; proteasome alpha4 subunit, Testis-specific 1; testes-specific proteasome subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17268); (R-DME-1169091); (R-DME-1234176); (R-DME-1236974); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9912633); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 50, "publication_count": 4, "publication_id_list": "10731132;12537572;15579695;8878681", "class_list": "", "function": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6QH19;Q8T8U0;Q9VDJ1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24192-1", "uniprot_id": "RHOL_DROME", "mass": 21880.0, "length": 190, "protein_name": "Ras-like GTP-binding protein RhoL", "gene_name": "RhoL", "organism": "Fruit fly", "refseq_name": "Rho-like, isoform A", "refseq_ac": "NP_524292", "gene_names_uniprotkb": "RhoL; CG9366; Drac3", "gene_names_refseq": "9366; CG9366; D-RhoL; DRhoL; DmRHO-L; Dmel\\CG9366; Drac3; G; Mes1; Rac3; RhoG; RhoL/Rac3; RhoL; Rhol; anon-EST:CL1c2; rhoL; rhol; rol", "protein_names_uniprotkb": "Ras-like GTP-binding protein RhoL; 3.6.5.2", "protein_names_refseq": "CG9366-PA; Rho-Like; Rho-like, isoform A; RhoL-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9366); (R-DME-4086400); (R-DME-9013423)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537572;8636236;9197407", "class_list": "", "function": "Essential for the maturation of hemocytes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q541G3;Q9U5D4;Q9VHC9", "ec_number_list": "2.7.11.1;3.6.5.5;3.6.5.2;3.6.5.-;3.1.3.56;2.7.10.2;3.6.5.3;2.7.10.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0042995 cell projection", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0007015 actin filament organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0016601 Rac protein signal transduction;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24192-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24210-3", "uniprot_id": "CSKP_DROME", "mass": 100911.0, "length": 898, "protein_name": "Peripheral plasma membrane protein CASK", "gene_name": "CASK", "organism": "Fruit fly", "refseq_name": "CASK, isoform D", "refseq_ac": "NP_001097862", "gene_names_uniprotkb": "CASK; CG6703; Caki; cmg", "gene_names_refseq": "CAKI; CAMGUK; CASK-beta; CASK; CG13412; CG13413; CG6703; CMG/CASK; CMG; CaSK; Caki; CamGUK; CamguK; Camguk; Cask; Cmg; DLin-2; Dmel\\CG6703; RE09582p; caki; camguk; cask; cmg; dCASK", "protein_names_uniprotkb": "Peripheral plasma membrane protein CASK; 2.7.11.17; CAKI; Calcium/calmodulin-dependent protein kinase; Camguk; dCASK", "protein_names_refseq": "CASK ortholog; CASK, isoform D; CASK-PD; CG6703-PD; Calcium/calmodulin-dependent protein kinase; Camguk/CASK adaptor protein; calmodulin-dependent kinase; camguk", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); FG syndrome (Disease Ontology:DOID:14711)", "pathway": " (dme:Dmel_CG6703); (R-DME-212676); (R-DME-6794361)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;14687552;15901771;16880127;19379781;8617233;9178262", "class_list": "", "function": "May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII. In neuromuscular junctions (NMJ), plays a role in synaptic vesicle recycling and thereby in neurotransmission (PubMed:19379781). Together with Nrx-1, required for locomotion (PubMed:19379781)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5X553;Q24272;Q86P03;Q86P17;Q8SX09;Q9VD77;Q9VD78;Q9VD79", "ec_number_list": "2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;5.6.1.8;2.7.11.11;2.7.11.23;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;2.7.11.39", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0031594 neuromuscular junction;GO:0097060 synaptic membrane;GO:0061174 type I terminal bouton", "go_biological_process": "GO:0008049 male courtship behavior;GO:0016080 synaptic vesicle targeting;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:2000331 regulation of terminal button organization;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q24210-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24239-1", "uniprot_id": "ANGEL_DROME", "mass": 40306.0, "length": 354, "protein_name": "Protein angel", "gene_name": "angel", "organism": "Fruit fly", "refseq_name": "angel", "refseq_ac": "NP_477204", "gene_names_uniprotkb": "angel; CG12273", "gene_names_refseq": "Angel; CG12273; CG1227; DmAngel; Dmel\\CG12273; angel", "protein_names_uniprotkb": "Protein angel; ANG39; Angel 39", "protein_names_refseq": "CG12273-PA; DmAngel; angel-PA; angel", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12273)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8809105", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W1L3", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0160273 RNA 2'-phosphatase activity;GO:0160272 RNA 2',3'-cyclic phosphatase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0090616 mitochondrial mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24239-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24266-1", "uniprot_id": "BTD_DROME", "mass": 68581.0, "length": 644, "protein_name": "Transcription factor btd", "gene_name": "btd", "organism": "Fruit fly", "refseq_name": "buttonhead", "refseq_ac": "NP_511100", "gene_names_uniprotkb": "btd; CG12653", "gene_names_refseq": "BTD; Btd; CG12653; Dmel\\CG12653; btd", "protein_names_uniprotkb": "Transcription factor btd; Protein buttonhead", "protein_names_refseq": "CG12653-PA; btd-PA; button-head; buttonhead", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12653); (R-DME-2173796); (R-DME-3232118); (R-DME-6807505); (R-DME-9018519); (R-DME-9762293)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10731132;12537572;8259212", "class_list": "", "function": "Required for the development of the antennal, intercalary and mandibular segments of the head., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W319", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045664 regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q24266-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24292-1", "uniprot_id": "DS_DROME", "mass": 385792.0, "length": 3556, "protein_name": "Protein dachsous", "gene_name": "ds", "organism": "Fruit fly", "refseq_name": "dachsous, isoform B", "refseq_ac": "NP_001285551", "gene_names_uniprotkb": "ds; CG17941", "gene_names_refseq": "CG17941; CT39575; DS; Dachsous; Dmel\\CG17941; Ds; EP-822; cad2; ds; l(2)01855; l(2)05142", "protein_names_uniprotkb": "Protein dachsous; Adherin", "protein_names_refseq": "CG17941-PB; cadherin-2; dachsous, isoform B; dachsous; daschous; ds-PB; lethal (2) 01855", "tax_id": 7227, "disease": "Van Maldergem syndrome 1 (Disease Ontology:DOID:0080585); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG17941); (R-DME-350379); (R-DME-390023); (R-DME-390150)", "pathway_count": 4, "publication_count": 27, "publication_id_list": "10490098;10731132;11893338;12015972;12506006;12537572;12540853;12642492;12756182;12941274;12941693;14502295;15240556;16687445;16735478;16980976;17174922;18327897;18555784;18635802;18804371;18849982;19540118;19574458;19710173;26073018;7601355", "class_list": "", "function": "Required for normal morphogenesis of adult structures derived from imaginal disks (PubMed:26073018, PubMed:7601355). Plays a role in planar cell polarity and in determining body left-right asymmetry. Expression in segment H1 of the imaginal ring and interaction with Myo31DF are required to induce changes of cell shape and orientation in segment H2, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:26073018)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 32, "predicted_n_glycosites": 31, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 32, "binding_glycan_count": 0, "secondary_ac_list": "Q9VPS4;X2J8E9", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016327 apicolateral plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0030855 epithelial cell differentiation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0035331 negative regulation of hippo signaling;GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q24292-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24298-1", "uniprot_id": "CADE_DROME", "mass": 169821.0, "length": 1507, "protein_name": "DE-cadherin", "gene_name": "shg", "organism": "Fruit fly", "refseq_name": "shotgun", "refseq_ac": "NP_476722", "gene_names_uniprotkb": "shg; CG3722; E-cadherin", "gene_names_refseq": "CADH; CG3722; CT12481; CadE; Cadh; Cad; D E-cad; D-CAD2; D-cad; DCAD2; DCAD; DCad2; DCad; DE Cadh; DE Cad; DE-CAD2; DE-CAD; DE-Cad2; DE-Cadherin; DE-Cadh; DE-Cad; DE-cadherin; DE-cadh; DE-cad; DECAD; DECadh; DECad; DEC; DE[cyto]; DEcad; DE; De-Cad; Dmel\\CG3722; E-CAD; E-Cadherin; E-Cadh; E-Cad; E-Ca; E-cadherin; E-cad; ECAD; ECad2; ECadherin; ECadh; ECad; Ecad; N-cad; Shg; Shotgun; cadh; cad; com5; dE-cadherin; dEcad; de-cad; e-cad; ecad; gp150; l(2)10469; l(2)k03401; l(2)k10220; shg/DE-Cad; shg", "protein_names_uniprotkb": "DE-cadherin; Protein shotgun", "protein_names_refseq": "CG3722-PA; Cadherin-E; D-Ecadherin; D-cadherin; DCAD2; DE cadherin; DE-cadherin/Shotgun; DEcadherin; De-cadherin; ECadherin; Shotgun/E-cadherin; compaction defects 5; drosophila E-cadherin; drosophila epithelial cadherin; drosophila melanogaster epithelial (DE)-cadherin; e-cadherin; eta-catenin; shg-PA; shotgun", "tax_id": 7227, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); Elsahy-Waters syndrome (Disease Ontology:DOID:0080631); agenesis of corpus callosum, cardiac, ocular, and genital syndrome (Disease Ontology:DOID:0080948); arrhythmogenic right ventricular dysplasia 14 (Disease Ontology:DOID:0080959); Teebi hypertelorism syndrome 2 (Disease Ontology:DOID:0081074); prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); thyroid gland carcinoma (Disease Ontology:DOID:3963); pulmonary hypertension (Disease Ontology:DOID:6432); intrinsic asthma (Disease Ontology:DOID:9360)", "pathway": " (dme:Dmel_CG3722)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537572;15047872;16831834;18327897;19682089;22491943;24681004;24855950;30763317;7958432", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins (PubMed:7958432). In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:7958432). During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte (PubMed:24855950, PubMed:30763317). Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surrounding nurse cells (PubMed:24855950). This adhesion increases Rac1 signaling in the leading cells, which in turn stabilizes DE-cadherin/DE-cadherin adhesions through the formation of forward-directed protrusions which attach/detach to the surrounding nurse cells in order to pull the cluster through the egg chamber to the oocyte (PubMed:24855950). Within the BC cluster, also promotes adhesion between BCs, and between BCs and polar cells which enables the lead BC to communicate direction to the other cells in the cluster, providing polarity to each individual cell and ensuring collective behavior (PubMed:24855950, PubMed:30763317). May function in cell intercalation in the lateral epidermis during germband extension (PubMed:24681004). Contributes to the determination of body left-right asymmetry by enhancing Myo31DF activity and inhibiting Myo61F activity (PubMed:22491943)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q9W2N1", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0017022 myosin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005938 cell cortex;GO:0055037 recycling endosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0007507 heart development;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q24298-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24317-1", "uniprot_id": "PRI1_DROME", "mass": 50222.0, "length": 438, "protein_name": "DNA primase small subunit", "gene_name": "Prim1", "organism": "Fruit fly", "refseq_name": "DNA primase subunit 1", "refseq_ac": "NP_523972", "gene_names_uniprotkb": "Prim1; CG7108; DNApol-alpha50; Pri50", "gene_names_refseq": "CG7108; DNA polalpha; DNApol-alpha50; DNApol-alpha; DNApolalpha-50; DNApolalpha50; DNApolalpha; Dmel\\CG7108; Dmpol alpha; Dpri50; POLA; PRI1; Pol-alpha50; Polalpha 50KDa; Polalpha 50kDa; Polalpha50; Polalpha; Pol; Prim1; anon-WO0140519.257; dnapol alpha 50; pol alpha; polalpha50; polalpha", "protein_names_uniprotkb": "DNA primase small subunit; 2.7.7.-; DNA polymerase subunit A; DNA polymerase subunit gamma; DNA primase 50 kDa subunit; dPRI50", "protein_names_refseq": "CG7108-PA; DNA polymerase 50K; DNA polymerase alpha 46,000 gamma subunit; DNA polymerase alpha 50 kda primase subunit; DNA polymerase alpha 50,000 gamma subunit; DNA polymerase alpha 50kD subunit; DNA polymerase alpha 50kD; DNA primase subunit 1; DNA-polymerase alpha; Prim1-PA; p50 subunit of DNA polymerase alpha", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7108); (R-DME-113501); (R-DME-68952); (R-DME-68962); (R-DME-69091); (R-DME-69166); (R-DME-69183)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;6403945;6409898;6773966;6806812;6812052;7929411", "class_list": "", "function": "Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:6403945, PubMed:6409898, PubMed:6773966, PubMed:6806812, PubMed:6812052). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (By similarity). Can add both ribo- and deoxynucleotides during elongation of the primers (PubMed:6812052). Binds single stranded DNA (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VSI0", "ec_number_list": "2.7.11.22;2.7.11.23;2.7.7.7;3.1.11.-;3.6.4.12;2.7.7.-;3.1.-.-;5.6.2.4", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0006269 DNA replication, synthesis of primer;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q24317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24320-1", "uniprot_id": "RPAB2_DROME", "mass": 14722.0, "length": 131, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC2", "gene_name": "Polr2F", "organism": "Fruit fly", "refseq_name": "RNA polymerase II, I and III subunit F", "refseq_ac": "NP_524910", "gene_names_uniprotkb": "Polr2F; CG1163; RPB6; RpABC14; RpII18", "gene_names_refseq": "BcDNA:RH21608; CG1163; Dm6; Dmel\\CG1163; H5; Pol II; PolII; Polr2F; RNA Pol II; RNA pol II; RNA polII; RNA polymerase II; RNAP II; RNAP; RNApolII; RPB6_DROME; RPB6; RPII18; RPO26; RpABC14; RpII18; Rpll18; pol II; polII; rpII18", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC2; RNA polymerase II, I and III subunit F; RNA polymerases I, II, and III subunit ABC2; RPB6 homolog", "protein_names_refseq": "CG1163-PA; Polr2F-PA; RNA polymerase II (18-kDa subunit); RNA polymerase II 18kD subunit; RNA polymerase II, I and III subunit F; RNA-polymerase ABC 14kD subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1163); (R-DME-112382); (R-DME-113418); (R-DME-5578749); (R-DME-674695); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6796648); (R-DME-6807505); (R-DME-72086); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-73762); (R-DME-73772); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-75955); (R-DME-76042); (R-DME-76061); (R-DME-76066); (R-DME-77075); (R-DME-9018519); (R-DME-9770562)", "pathway_count": 26, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;7651387", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, Polr2F/RPB6 is part of the clamp element and together with parts of Polr2A/RPB1 and RPB2 forms a pocket to which the Polr2D/RPB4-Polr2G/RPB7 subcomplex binds (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VNA7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24320-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24325-1", "uniprot_id": "TAF2_DROME", "mass": 139499.0, "length": 1221, "protein_name": "Transcription initiation factor TFIID subunit 2", "gene_name": "Taf2", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 2, isoform B", "refseq_ac": "NP_001261668", "gene_names_uniprotkb": "Taf2; CG6711; TAF150", "gene_names_refseq": "CG6711; Dmel\\CG6711; TAF150; TAF2; TAFII150; TAF[II]150; TAF[[II]]150; TAF[[II]]; TAF; TFIID; Taf150; Taf2; TafII150; Taf[[II]]150; dTAF II 150; dTAF150; dTAFII150; dTAF[[II]]150; taf2", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 2; TAF(II)150; TAFII-150; TAFII150; Transcription initiation factor TFIID 150 kDa subunit", "protein_names_refseq": "CG6711-PB; TBP-associated factor 150kD; TBP-associated factor 2, isoform B; Taf2-PB", "tax_id": 7227, "disease": "autosomal recessive intellectual developmental disorder 40 (Disease Ontology:DOID:0081205)", "pathway": " (dme:Dmel_CG6711); (R-DME-674695); (R-DME-6804756); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;8178153;8276241", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. An essential subunit binds to core promoter DNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZR7;Q9VT64", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006352 DNA-templated transcription initiation;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q24325-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24338-1", "uniprot_id": "ESC_DROME", "mass": 47988.0, "length": 425, "protein_name": "Polycomb protein esc", "gene_name": "esc", "organism": "Fruit fly", "refseq_name": "extra sexcombs", "refseq_ac": "NP_477431", "gene_names_uniprotkb": "esc; CG14941", "gene_names_refseq": "CG14941; Dmel\\CG14941; ESC; Esc; L41867; dESC; esc; sc", "protein_names_uniprotkb": "Polycomb protein esc; Protein extra sex combs", "protein_names_refseq": "CG14941-PA; esc-PA; extra Sex combs; extra sex comb; extra sexcombs", "tax_id": 7227, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dme:Dmel_CG14941)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;10757791;11124122;11581156;12408863;12408864;12533794;12537569;12537572;12697833;12771214;18327897;22354997;7556071;9566901", "class_list": "", "function": "Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035098 ESC/E(Z) complex;GO:0035097 histone methyltransferase complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0009948 anterior/posterior axis specification;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q24338-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24352-1", "uniprot_id": "GBRAL_DROME", "mass": 76558.0, "length": 686, "protein_name": "Gamma-aminobutyric acid receptor alpha-like", "gene_name": "Grd", "organism": "Fruit fly", "refseq_name": "glycine receptor", "refseq_ac": "NP_524131", "gene_names_uniprotkb": "Grd; CG7446", "gene_names_refseq": "CG7446; CT22917; DmGABA(GRD); Dmel\\CG7446; GRD; Grd", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor alpha-like; GABA(A) receptor alpha-like and glycine receptor-like subunit of Drosophila; GRD", "protein_names_refseq": "CG7446-PA; GABA and glycine-like receptor of drosophila; GABA-and-glycine-receptor-like-subunit-of-Drosophila; GABA/Glycine-gated chloride channel-like; Grd-PA; glycine receptor", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); developmental and epileptic encephalopathy 19 (Disease Ontology:DOID:0080431); developmental and epileptic encephalopathy 78 (Disease Ontology:DOID:0112214); developmental and epileptic encephalopathy 79 (Disease Ontology:DOID:0112215); autistic disorder (Disease Ontology:DOID:12849); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (dme:Dmel_CG7446); (R-DME-977443)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;15148245;8189252", "class_list": "", "function": "GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. May combine with the ligand-gated ion channel subunit Lcch3 to form cation-selective GABA-gated ion channels., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9TX50;Q9VVL3", "ec_number_list": "", "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0022852 glycine-gated chloride ion channel activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0005261 monoatomic cation channel activity;GO:0004890 GABA-A receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0060012 synaptic transmission, glycinergic;GO:0006811 monoatomic ion transport;GO:0042752 regulation of circadian rhythm;GO:1902476 chloride transmembrane transport;GO:1904456 negative regulation of neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24352-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24395-1", "uniprot_id": "MTK_DROME", "mass": 5654.0, "length": 52, "protein_name": "Metchnikowin", "gene_name": "Mtk", "organism": "Fruit fly", "refseq_name": "metchnikowin", "refseq_ac": "NP_523752", "gene_names_uniprotkb": "Mtk; CG8175", "gene_names_refseq": "BcDNA:RH07954; CG8175; DIM 17; Dmel\\CG8175; METCH; Mek; Metch; Metc; Mtk; metch; metk; mtk", "protein_names_uniprotkb": "Metchnikowin", "protein_names_refseq": "CG8175-PA; Mtk-PA; drosophila immune induced molecule 17; metchikowin; metchinkowin; metchnikovin; metchnikowin A; metchnikowin B; metchnikowin precursor; metchnikowin-1; metchnikowin-2; metchnikowine; metchnikowin; metchnkowin; takeout", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8175)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;12716986;7588819;9600835;9736738", "class_list": "", "function": "Potent antifungal and antibacterial activity against Gram-positive bacteria., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24396;Q86BV8;Q9V7B9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q24395-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24407-1", "uniprot_id": "ATP5J_DROME", "mass": 11936.0, "length": 106, "protein_name": "ATP synthase-coupling factor 6, mitochondrial", "gene_name": "ATPsynCF6", "organism": "Fruit fly", "refseq_name": "ATP synthase, coupling factor 6, isoform B", "refseq_ac": "NP_001247264", "gene_names_uniprotkb": "ATPsynCF6; CG4412", "gene_names_refseq": "ATPR; ATPsyn-Cf6; ATPsynCF6; BcDNA:RH08870; CG4412; Dmel\\CG4412", "protein_names_uniprotkb": "ATP synthase-coupling factor 6, mitochondrial; ATPase subunit F6", "protein_names_refseq": "ATP synthase coupling factor 6; ATP synthase, coupling factor 6, isoform B; ATPase coupling factor 6; ATPase coupling-factor 6; ATPsynCF6-PB; CG4412-PB; F0/F1 ATP synthase coupling factor 6; broadly-expressed subunit F6", "tax_id": 7227, "disease": "essential hypertension (Disease Ontology:DOID:10825); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dme:Dmel_CG4412); (R-DME-163210); (R-DME-8949613); (R-DME-9837999)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10071211;10731132;12537569;12537572", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VCN0", "ec_number_list": "", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24407-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24472-1", "uniprot_id": "RBF_DROME", "mass": 96826.0, "length": 845, "protein_name": "Retinoblastoma family protein", "gene_name": "Rbf", "organism": "Fruit fly", "refseq_name": "Retinoblastoma-family protein", "refseq_ac": "NP_525036", "gene_names_uniprotkb": "Rbf; CG7413", "gene_names_refseq": "CG7413; Dmel\\CG7413; EG:34F3.3; FBF; RBF1; RBF; RBf1; RB; Rb1; RbF1; RbF; Rbf1; Rbf; Rb; dRBF; pRb; rbf1; rbf; rb", "protein_names_uniprotkb": "Retinoblastoma family protein", "protein_names_refseq": "CG7413-PA; Rbf-PA; Retinoblastoma-family protein; retinoblastoma factor-1; retinoblastoma family protein 1; retinoblastoma-family homolog", "tax_id": 7227, "disease": "Brunet-Wagner neurodevelopmental syndrome (Disease Ontology:DOID:0061126); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG7413); (R-DME-113501); (R-DME-1538133); (R-DME-174178); (R-DME-2173796); (R-DME-69200); (R-DME-69202); (R-DME-69231); (R-DME-69656); (R-DME-9841922)", "pathway_count": 10, "publication_count": 9, "publication_id_list": "10731132;10731137;12537569;12537572;15479636;15545624;18250149;18327897;8675008", "class_list": "", "function": "Functions in cell cycle regulation. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O77272;Q961U8", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0070176 DRM complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:1900117 regulation of execution phase of apoptosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q24472-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24478-1", "uniprot_id": "CP190_DROME", "mass": 121679.0, "length": 1096, "protein_name": "Centrosome-associated zinc finger protein Cp190", "gene_name": "Cp190", "organism": "Fruit fly", "refseq_name": "centrosomal protein 190kD, isoform A", "refseq_ac": "NP_524359", "gene_names_uniprotkb": "Cp190; CG6384; DMAP190; E(mod)4-1", "gene_names_refseq": "AbS1-4; Bx-63; Bx63; CEN190; CG6384; CP-190; CP-60; CP190_DROME; CP190; Cen185; Cen190; Cp190; DMAP 190; DMAP-190; DMAP190; Dmap190; Dmel\\CG6384; E(mod)4-1; Map190; Rb188; cp190; dmap190", "protein_names_uniprotkb": "Centrosome-associated zinc finger protein Cp190; Centrosomal protein 190kD; Microtubule associated protein 190kD; Protein enhancer of mod(mdg4)4-1", "protein_names_refseq": "CG6384-PA; Cp190-PA; E(mod)4-1; centrosomal protein 190 kDa; centrosomal protein 190kD, isoform A; centrosomal protein 90; centrosomal protein of 190 kDa; enhancer of mod(mdg4)4-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6384)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10731132;12537572;1372522;14996941;15479719;15574329;16051175;16209949;17372656;18327897;25342723;25561495;26649574;28366641;33752739;38769058;8491775;8522588;8586650;8590797;9247191;9256351;9700165", "class_list": "", "function": "Plays a central role in chromatin domain organization and boundary function through recruitment by a range of insulator DNA-binding proteins, including ZIPIC, pita, CTCF, su(Hw), cliff and others (PubMed:25342723, PubMed:33752739, PubMed:38769058). Together with pita and CTCF cooperatively binds to and regulates the activity of the Miscadastral pigmentation (MCP) insulator (PubMed:25342723). Cooperatively recruited to the front-ultraabdominal (Fub) boundary by pita, su(Hw) and cliff (PubMed:38769058). Recruitment of Cp190 together with Chro/chromator induces chromatin decondensation (PubMed:33752739). Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators (PubMed:15574329). Chromatin insulators are regulatory elements that establish independent domains of transcriptional activity within eukaryotic genomes (Probable). Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV) (Probable). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops to form topologically associating domains (TADs) (Probable). This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery (Probable). Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw) (PubMed:15574329). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo (PubMed:16051175). Associates with centrosomes and interphase microtubules during mitosis, and recruits CP60; may have a role in maintaining centrosome and spindle integrity (PubMed:14996941, PubMed:16051175, PubMed:26649574)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2Y3;Q9VFA1", "ec_number_list": "", "go_molecular_function": "GO:0043035 chromatin insulator sequence binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008017 microtubule binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0000793 condensed chromosome;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0051493 regulation of cytoskeleton organization;GO:0035191 nuclear axial expansion", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q24478-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24491-1", "uniprot_id": "RX21_DROME", "mass": 21438.0, "length": 200, "protein_name": "RNA-binding protein Rsf1", "gene_name": "Rsf1", "organism": "Fruit fly", "refseq_name": "repressor splicing factor 1, isoform B", "refseq_ac": "NP_001260318", "gene_names_uniprotkb": "Rsf1; CG5655; ROX21", "gene_names_refseq": "CG5655; Dmel\\CG5655; ROX21; RSF1; Rox21; Rsf1; dRSF1; rox21", "protein_names_uniprotkb": "RNA-binding protein Rsf1; RNA-binding protein Rox21", "protein_names_refseq": "CG5655-PB; Rsf1-PB; repressor splicing factor 1, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5655); (R-DME-159236); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-9770562)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;7890163", "class_list": "", "function": "May control important aspects of development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24424;Q8SYR3;Q9VL15", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0010468 regulation of gene expression;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0031440 regulation of mRNA 3'-end processing;GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24492-1", "uniprot_id": "RFA1_DROME", "mass": 66624.0, "length": 603, "protein_name": "Replication protein A 70 kDa DNA-binding subunit", "gene_name": "RPA1", "organism": "Fruit fly", "refseq_name": "replication protein A1", "refseq_ac": "NP_524274", "gene_names_uniprotkb": "RPA1; CG9633", "gene_names_refseq": "CG9633; D-RPA70; D-SSB; DRP-A; DmRPA; Dmel\\CG9633; RP-A; RPA 70 kDa; RPA 70; RPA1; RPA70; RPA; RpA-70; RpA1; RpA70; Rpa-70; Ssb-70; dRP-A; dmrpa1; i164", "protein_names_uniprotkb": "Replication protein A 70 kDa DNA-binding subunit; DmRPA1; RF-A protein 1; RP-A p70; Replication factor A protein 1; Single-stranded DNA-binding protein", "protein_names_refseq": "CG9633-PA; RPA1-PA; drosophila replication protein A; replication protein A 70; replication protein A1; single stranded-binding protein 70", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9633)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VHU3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0003697 single-stranded DNA binding;GO:0043047 single-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0006289 nucleotide-excision repair;GO:0051321 meiotic cell cycle;GO:0007004 telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24492-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24536-1", "uniprot_id": "SSL_DROME", "mass": 25191.0, "length": 219, "protein_name": "Suppressor-of-stellate-like protein", "gene_name": "Ssl", "organism": "Fruit fly", "refseq_name": "suppressor of Stellate-like", "refseq_ac": "NP_523848", "gene_names_uniprotkb": "Ssl; CG13591", "gene_names_refseq": "CG13591; CK2betates; CKIIb1; Dm-CK2-beta[Tes]; DmCK2betates; Dmel\\CG13591; NEST:bs30a09; SSL; Ssl; Su(Ste)l; betaCK2tes", "protein_names_uniprotkb": "Suppressor-of-stellate-like protein; Su(ste)-like; Suste-like protein", "protein_names_refseq": "CG13591-PA; Ssl-PA; Su(Ste)-like; regulatory subunit of protein kinase CK2; suppressor of Stellate-like; suppressor of stellate like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13591)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9177211", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZV0;Q24540;Q9W163", "ec_number_list": "", "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24536-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q24583-1", "uniprot_id": "VATF1_DROME", "mass": 13850.0, "length": 124, "protein_name": "V-type proton ATPase subunit F 1", "gene_name": "Vha14-1", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase 14kD subunit 1", "refseq_ac": "NP_476969", "gene_names_uniprotkb": "Vha14-1; CG8210; Vha14", "gene_names_refseq": "ATP6V1F; ATPase; CG8210; Dmel\\CG8210; VAF1_DROME; Vha14-1; Vha14; l(2)SH1248; l(2)SH2 1248; vha14-1; vha14", "protein_names_uniprotkb": "V-type proton ATPase subunit F 1; V-ATPase 14 kDa subunit; V-ATPase subunit F 1; Vacuolar H+ ATPase subunit 14-1; Vacuolar proton pump subunit F 1", "protein_names_refseq": "CG8210-PA; F subunit; V-ATPase 14kD subunit; V-ATPase proton pump; Vha14-1-PA; lethal (2) SH1248; vacuolar H[+] ATPase 14kD subunit 1; vacuolar H[+] ATPase 14kD subunit; vacuolar H[+] ATPase subunit 14-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8210); (R-DME-1222556); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10731132;12537572;18327897;8682310", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C4XVH6;Q9V7E2", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0016020 membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24583-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q26263-1", "uniprot_id": "DPN_DROME", "mass": 46551.0, "length": 435, "protein_name": "Protein deadpan", "gene_name": "dpn", "organism": "Fruit fly", "refseq_name": "deadpan", "refseq_ac": "NP_476923", "gene_names_uniprotkb": "dpn; CG8704", "gene_names_refseq": "44C; CG8704; DPN; Deadpan; Dmel\\CG8704; Dpn; anon-EST:fe1B12; bHLHe50; dpn", "protein_names_uniprotkb": "Protein deadpan", "protein_names_refseq": "CG8704-PA; Dead-pan; anon-fast-evolving-1B12; deadpan; dpn-PA", "tax_id": 7227, "disease": "brain cancer (Disease Ontology:DOID:1319); epilepsy (Disease Ontology:DOID:1826); hemangiopericytoma (Disease Ontology:DOID:264); acute kidney failure (Disease Ontology:DOID:3021); central nervous system cancer (Disease Ontology:DOID:3620); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (dme:Dmel_CG8704)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537569;12537572;1427077;18327897;21262215;22357926;23056424;24618901;28899667;33109704;7651341;8001118", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription (PubMed:1427077, PubMed:24618901, PubMed:28899667). In the larval brain, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma-HLH (PubMed:21262215, PubMed:22357926, PubMed:23056424, PubMed:24618901, PubMed:28899667). As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch (PubMed:21262215, PubMed:22357926, PubMed:23056424). In the developing larval and pupal brain, required for mushroom body differentiation (PubMed:22357926). Involved in sex determination and SXL transcription repression when in complex with the corepressor protein Groucho (PubMed:7651341, PubMed:8001118)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9V384", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008344 adult locomotory behavior;GO:0010629 negative regulation of gene expression;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q26263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q26377-1", "uniprot_id": "CORZ_DROME", "mass": 17154.0, "length": 154, "protein_name": "Pro-corazonin", "gene_name": "Crz", "organism": "Fruit fly", "refseq_name": "corazonin", "refseq_ac": "NP_524350", "gene_names_uniprotkb": "Crz; CG3302", "gene_names_refseq": "CG3302; CORZ; COR; CRZ; Cora; Crz; Dm-Crz; Dmel\\CG3302; Drm-COR; cor; crz", "protein_names_uniprotkb": "Pro-corazonin; Crz-associated peptide; Crz; Dm-Crz", "protein_names_refseq": "CG3302-PA; Crz-PA; corazonin; preprocorazonin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3302)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12171930;12537572;15174081;15669053;18087727;7945373", "class_list": "", "function": "Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. Clock (Clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VFK7", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0071858 corazonin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0048149 behavioral response to ethanol;GO:0071361 cellular response to ethanol;GO:0045823 positive regulation of heart contraction;GO:0006117 acetaldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q26377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27333-1", "uniprot_id": "ALG3_DROME", "mass": 58406.0, "length": 510, "protein_name": "Dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase Alg3", "gene_name": "Alg3", "organism": "Fruit fly", "refseq_name": "ALG3, alpha-1,3- mannosyltransferase", "refseq_ac": "NP_523829", "gene_names_uniprotkb": "Alg3; CG4084; l(2)not; l(2)tid; tid", "gene_names_refseq": "1(2) not; ALG3; Alg3; CG4084; Dmel\\CG4084; L(2)NOT; NOT; alg3; cDNA 10F; dAlg3; l(2)not; l(2)td; l(2)tid; l(2)tud; ntid; tid", "protein_names_uniprotkb": "Dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase Alg3; 2.4.1.258; Alpha-1,3-mannosyltransferase Alg3; Asparagine-linked glycosylation protein 3 homolog; Lethal(2)neighbor of tid protein; Lethal(2)tumorous imaginal discs; NOT45; NOT56", "protein_names_refseq": "ALG3, alpha-1,3- mannosyltransferase; Alg3-PA; Asparagine-Linked Glycosylation-3; CG4084-PA; alpha1,3-mannosyltransferase; l(2)tumorous disc; l(2)tumorous imaginal discs; lethal (2) neighbor of tid; lethal(2) neighbour of 1(2)tid; lethal(2) tumorous imaginal discs; lethal(2)neighbour of tid; lethal(2)tumorous imaginal discs", "tax_id": 7227, "disease": "congenital disorder of glycosylation Id (Disease Ontology:DOID:0080556); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (dme:Dmel_CG4084); (R-DME-446193)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;1473626;29870719;38944657;9373138", "class_list": "", "function": "Probable alpha-1,3-mannosyltransferase involved in the N-glycosylation pathway (PubMed:29870719). Involved in glycosylation of the TNF receptor grnd, regulating its ligand affinity (PubMed:29870719). Required for normal epithelial growth and architecture (PubMed:29870719). Suppressor of JNK-dependent intestinal stem cell proliferation (PubMed:38944657)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C4IXX8;O02532;O02533;Q24419;Q24420;Q24421;Q24607;Q95R76;Q9W1K8", "ec_number_list": "2.4.1.258", "go_molecular_function": "GO:0052925 dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q27333-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q27896-1", "uniprot_id": "TRF_DROME", "mass": 25456.0, "length": 224, "protein_name": "TBP-related factor", "gene_name": "Trf", "organism": "Fruit fly", "refseq_name": "TBP-related factor", "refseq_ac": "NP_476939", "gene_names_uniprotkb": "Trf; CG7562", "gene_names_refseq": "CG7562; Dmel\\CG7562; TRF1; TRF; Trf1; Trf; X70838; dTRF-1; dTRF1; trf1; trf", "protein_names_uniprotkb": "TBP-related factor", "protein_names_refseq": "CG7562-PA; TBP-related factor; Trf-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7562)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8429912", "class_list": "", "function": "Acts as a transcription factor. Binds to the TATA box promoter element which lies close to the position of transcription initiation., [UniProtKB]; May be essential for embryonic development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001025 RNA polymerase III general transcription initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0005669 transcription factor TFIID complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006383 transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q27896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4V645-1", "uniprot_id": "TRISS_DROME", "mass": 12573.0, "length": 108, "protein_name": "Trissin", "gene_name": "Trissin", "organism": "Fruit fly", "refseq_name": "trissin", "refseq_ac": "NP_650471", "gene_names_uniprotkb": "Trissin; CG14871", "gene_names_refseq": "CG14871; Dmel\\CG14871; Trissin", "protein_names_uniprotkb": "Trissin", "protein_names_refseq": "CG14871-PB; Trissin-PB; trissin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14871)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21939639", "class_list": "", "function": "Activates the G protein-coupled receptor TrissinR in vitro, leading to increased intracellular calcium ion levels., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VF57", "ec_number_list": "", "go_molecular_function": "GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4V645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q59E14-1", "uniprot_id": "Q59E14_DROME", "mass": 52553.0, "length": 468, "protein_name": "Neural cell adhesion molecule 2", "gene_name": "elff", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_001014458", "gene_names_uniprotkb": "elff; 33543; CG15354; CG15355; CG33543; CT35363; CT35364; Dmel\\CG33543; Dmel_CG33543", "gene_names_refseq": "33543; CG15354; CG15355; CG33543; CT35363; CT35364; Dmel\\CG33543", "protein_names_uniprotkb": "Neural cell adhesion molecule 2", "protein_names_refseq": "CG33543-PD; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33543); (R-DME-1474228); (R-DME-1971475); (R-DME-2022928); (R-DME-2024096); (R-DME-216083); (R-DME-3000171); (R-DME-3000178); (R-DME-375165); (R-DME-419037); (R-DME-445144); (R-DME-5673001); (R-DME-9769739); (R-DME-9913351)", "pathway_count": 14, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0030154 cell differentiation;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0009653 anatomical structure morphogenesis;GO:0007444 imaginal disc development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q59E14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5BI42-1", "uniprot_id": "CAHD1_DROME", "mass": 162091.0, "length": 1449, "protein_name": "VWFA and cache domain-containing protein CG16868", "gene_name": "CG16868", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_611469", "gene_names_uniprotkb": "CG16868", "gene_names_refseq": "CG16868; Dmel\\CG16868", "protein_names_uniprotkb": "VWFA and cache domain-containing protein CG16868", "protein_names_refseq": "CG16868-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16868)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 14, "predicted_n_glycosites": 13, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BI42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6WV19-1", "uniprot_id": "GALT2_DROME", "mass": 70736.0, "length": 633, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 2", "gene_name": "Pgant2", "organism": "Fruit fly", "refseq_name": "polypeptide N-Acetylgalactosaminyltransferase 2, isoform A", "refseq_ac": "NP_608773", "gene_names_uniprotkb": "Pgant2; CG3254", "gene_names_refseq": "CG3254; DmGalNAc-T2; Dmel\\CG3254; PGANT2; Pgant2; pgant2", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 2; 2.4.1.41; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; pp-GaNTase 2", "protein_names_refseq": "CG3254-PA; Pgant2-PA; polypeptide GalNAc transferase 2; polypeptide N-Acetylgalactosaminyltransferase 2, isoform A", "tax_id": 7227, "disease": "congenital disorder of glycosylation type IIt (Disease Ontology:DOID:0051049)", "pathway": " (dme:Dmel_CG3254); (R-DME-6811436); (R-DME-913709)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;12537572;12829714;16251381;18669915;20807760;22157008", "class_list": "", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714, PubMed:18669915). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers the monoglycosylated Muc5AC-3 as substrate (PubMed:12829714). O-glycosylation modification of proteins by this enzyme might be important for cytokinesis (PubMed:20807760)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KU27;Q7YU21;Q9VQQ2", "ec_number_list": "3.6.5.-;2.4.1.-;2.4.1.41", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005795 Golgi stack", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6WV19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JRP4-1", "uniprot_id": "CMIP2_DROME", "mass": 36822.0, "length": 323, "protein_name": "CIMIP2 protein CG18335", "gene_name": "CG18335", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_610666", "gene_names_uniprotkb": "CG18335", "gene_names_refseq": "CG18335; Dmel\\CG18335", "protein_names_uniprotkb": "CIMIP2 protein CG18335", "protein_names_refseq": "CG18335-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18335)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Probable microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilium axoneme., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0005930 axoneme", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7JRP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JVL3-1", "uniprot_id": "PRP38_DROME", "mass": 40088.0, "length": 330, "protein_name": "Pre-mRNA-splicing factor 38", "gene_name": "Prp38", "organism": "Fruit fly", "refseq_name": "pre-mRNA processing factor 38", "refseq_ac": "NP_610463", "gene_names_uniprotkb": "Prp38; CG30342", "gene_names_refseq": "CG30342; CG8054; Dmel\\CG30342; Prp38; dprp38; prp38", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 38", "protein_names_refseq": "CG30342-PA; Prp38-PA; pre-mRNA processing factor 38", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30342)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18765666;18981222;24244416", "class_list": "", "function": "Required for pre-mRNA splicing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0032991 protein-containing complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7JVL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JVR7-1", "uniprot_id": "CSN9_DROME", "mass": 7581.0, "length": 67, "protein_name": "COP9 signalosome complex subunit 9 homolog", "gene_name": "CG17059", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_652383", "gene_names_uniprotkb": "CG17059", "gene_names_refseq": "BcDNA:GH04581; CG17059; Dmel\\CG17059", "protein_names_uniprotkb": "COP9 signalosome complex subunit 9 homolog", "protein_names_refseq": "CG17059-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17059)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7JVR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JW27-1", "uniprot_id": "WASH1_DROME", "mass": 53210.0, "length": 499, "protein_name": "WASH complex subunit 1", "gene_name": "wash", "organism": "Fruit fly", "refseq_name": "washout, isoform B", "refseq_ac": "NP_001286334", "gene_names_uniprotkb": "wash; CG13176", "gene_names_refseq": "CG13176; Dmel\\CG13176; WASH; Wash; p63; p65; wash", "protein_names_uniprotkb": "WASH complex subunit 1; Protein washout; WAS protein family homolog 1", "protein_names_refseq": "CG13176-PB; wash-PB; washout, isoform B; washout", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13176); (R-DME-2029482); (R-DME-5663213)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;18159949;18327897;19633175;20498093;25739458", "class_list": "", "function": "Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization (PubMed:19633175). Participates in both linear- and branched-actin networks (PubMed:19633175). Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis (PubMed:19633175). Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber (PubMed:19633175). During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). Its function in hemocyte transmigration is independent of the WASH complex (PubMed:25739458). May play a role in endosomal sorting; its assembly in the WASH complex may regulate its nucleation-promoting factor (NPF) activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LF66", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003779 actin binding;GO:0051020 GTPase binding;GO:0005521 lamin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0033044 regulation of chromosome organization;GO:0015031 protein transport;GO:0030036 actin cytoskeleton organization;GO:0033630 positive regulation of cell adhesion mediated by integrin;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7JW27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7JZM8-1", "uniprot_id": "RM41_DROME", "mass": 18565.0, "length": 166, "protein_name": "Large ribosomal subunit protein mL41", "gene_name": "mRpL41", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L41", "refseq_ac": "NP_611022", "gene_names_uniprotkb": "mRpL41; CG12954", "gene_names_refseq": "BcDNA:RE19416; CG12954; Dmel\\CG12954; YmL27; mRpL41", "protein_names_uniprotkb": "Large ribosomal subunit protein mL41; 39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41", "protein_names_refseq": "CG12954-PA; mRpL41-PA; mitochondrial ribosomal protein L41", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12954); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1Z9Y9", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7JZM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K0Y1-1", "uniprot_id": "BOP1_DROME", "mass": 90444.0, "length": 784, "protein_name": "Ribosome biogenesis protein BOP1 homolog", "gene_name": "CG5033", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_611270", "gene_names_uniprotkb": "CG5033", "gene_names_refseq": "BOP1; CG5033; Dmel\\CG5033; EG:52C10.1; dWDR36", "protein_names_uniprotkb": "Ribosome biogenesis protein BOP1 homolog", "protein_names_refseq": "CG5033-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5033); (R-DME-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;10731137;12537569;12537572", "class_list": "", "function": "Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7JQW4", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0035206 regulation of hemocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7K0Y1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7K284-1", "uniprot_id": "CLP1_DROME", "mass": 46791.0, "length": 423, "protein_name": "Protein CLP1 homolog", "gene_name": "cbc", "organism": "Fruit fly", "refseq_name": "crowded by cid", "refseq_ac": "NP_610876", "gene_names_uniprotkb": "cbc; CG5970", "gene_names_refseq": "CBC; CG5970; Cbc; Dmel\\CG5970; cbc; cg5970", "protein_names_uniprotkb": "Protein CLP1 homolog; Crowded by cid", "protein_names_refseq": "CG5970-PA; cbc-PA; crowded by cid", "tax_id": 7227, "disease": "pontocerebellar hypoplasia type 10 (Disease Ontology:DOID:0060279)", "pathway": " (dme:Dmel_CG5970); (R-DME-73856); (R-DME-77595); (R-DME-9770562)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation., [UniProtKB, HAMAP]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005849 mRNA cleavage factor complex;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0007420 brain development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7K284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KLI1-1", "uniprot_id": "APAF_DROME", "mass": 165619.0, "length": 1440, "protein_name": "Apoptosome protein Dark", "gene_name": "Dark", "organism": "Fruit fly", "refseq_name": "Death-associated APAF1-related killer, isoform B", "refseq_ac": "NP_725637", "gene_names_uniprotkb": "Dark; Apaf-1; Ark; CG6829; Hac-1; dapaf-1", "gene_names_refseq": "APAF-1; APAF1; ARK; Apaf-1; Apaf1; Apaf; Ark; CG6829; D-Apaf-1; DARK; Dapaf-1/HAC-1; Dapaf-1; Dark/Apaf-I; Dark/Dapaf-1/HAC1; Dark/Hac-1/dApaf-1; Dark/Hac-1/dApaf1; Dark; Dmel\\CG6829; Hac-1/Dark; Hac-1; Hac1; T1; anon-53Fa; apaf-1; apaf1; arc; ark; dAPAF-1; dApaf-1/DARK/HAC-1; dApaf-1; dApaf1; dArk; dapaf-1L; dapaf-1S; dapaf-1; dapaf; dark/dapaf-1/hac-1; dark/hac-1/dapaf-1; dark; dpf; hac-1; hac1; l(2)SH0173", "protein_names_uniprotkb": "Apoptosome protein Dark; Death-associated APAF1-related killer; Drosophila Apaf-1 related killer; Homolog of Apaf-1 and ced-4", "protein_names_refseq": "Apaf-1 related killer; Apaf-1-related-killer; CG6829-PB; Dark-PB; Death-associated APAF1-related killer, isoform B; apaf1-related killer; dark; drosophila Apaf-1-related killer; lethal (2) SH0173; transcription unit 1", "tax_id": 7227, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); Noonan syndrome (Disease Ontology:DOID:3490); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (dme:Dmel_CG6829); (R-DME-111458); (R-DME-111459); (R-DME-6798695); (R-DME-9627069)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10559939;10619022;10619023;10731132;10984473;11901172;12537572;16310803;16533943;16645639;21220123;25644603;27916517;38381783", "class_list": "", "function": "Main component of the apoptosome, an adapter protein complex that mediates activation of the caspase cascade in programmed cell death initiated by the intrinsic apoptosis pathway (PubMed:10984473, PubMed:16310803, PubMed:21220123, PubMed:25644603, PubMed:27916517). Recruits the initiator caspase Dronc, promoting its autocatalytic cleavage and activation; triggers the caspase cascade upstream of the effector caspases Drice and dcp-1 (PubMed:10619022, PubMed:10619023, PubMed:10984473, PubMed:21220123, PubMed:25644603). Effector of reaper, grim and hid induced cell killing (PubMed:10559939, PubMed:10619023, PubMed:16645639). Produces at least two isoforms that may activate distinct caspases by separate pathways (PubMed:10619023). Nucleotide binding protein with strong specificity for dATP; dATP binding is not essential, but promotes homooligomerization to form the apoptosome complex (PubMed:10619022, PubMed:10619023, PubMed:16310803, PubMed:21220123, PubMed:25644603, PubMed:27916517). There is currently no evidence of dATPase activity and structural analysis of the nucleotide binding pocket suggests negligible to no dATPase activity (Probable). Caspase activation by the apoptosome was initially thought to be dependent on binding of cytochrome c released from mitochondria, as is the case for vertebrate orthologs (PubMed:10619022, PubMed:10619023). Apoptosis induction by the Dark apoptosome appears to be cytochrome c independent (PubMed:11901172). Required for stress-induced apoptosis, for example in response to radiation (UV or gamma) or treatment with macromolecular synthesis inhibitors like cycloheximide and actinomycin D (PubMed:11901172, PubMed:16533943). Required for most, but not all programmed cell death during embryonic development (PubMed:16645639). Involved in developmental cell number regulation by apoptosis, particularly during neuronal and sensory organ development (PubMed:10559939, PubMed:10619022, PubMed:10619023, PubMed:16533943, PubMed:16645639). Involved in reduction of midline glial cell numbers by programmed cell death during embryogenesis (PubMed:16645639). During metamorphosis involved in removal of larval salivary glands by programmed cell death, but not of the larval midgut (PubMed:16533943)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U8R4", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0043531 ADP binding;GO:0005198 structural molecule activity;GO:0050700 CARD domain binding", "go_cellular_component": "GO:0043293 apoptosome", "go_biological_process": "GO:0010332 response to gamma radiation;GO:0042594 response to starvation;GO:0070050 neuron cellular homeostasis;GO:0006915 apoptotic process;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7KLI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KML2-1", "uniprot_id": "ACOX1_DROME", "mass": 74287.0, "length": 669, "protein_name": "Acyl-coenzyme A oxidase 1", "gene_name": "Acox1", "organism": "Fruit fly", "refseq_name": "acyl-CoA oxidase 1", "refseq_ac": "NP_611264", "gene_names_uniprotkb": "Acox1; CG5009", "gene_names_refseq": "ACOX1; BcDNA:GH07485; CG5009; Dmel\\CG5009; GH07485; dACOX1", "protein_names_uniprotkb": "Acyl-coenzyme A oxidase 1; 1.3.3.6", "protein_names_refseq": "ACOX1-PA; CG5009-PA; acyl-CoA oxidase 1", "tax_id": 7227, "disease": "peroxisomal acyl-CoA oxidase deficiency (Disease Ontology:DOID:0050797); Mitchell syndrome (Disease Ontology:DOID:0070516); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG5009); (R-DME-193368); (R-DME-2046106); (R-DME-389887); (R-DME-390247); (R-DME-9033241)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10731132;10731138;12537569;12537572;17372656;32169171", "class_list": "", "function": "Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95ST5", "ec_number_list": "2.3.1.42;1.1.3.15;1.1.1.42;6.2.1.3;1.11.1.6;3.4.24.56;1.14.13.39;1.3.3.6;2.3.-.-;2.3.1.137;2.3.1.7;5.1.99.4;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;1.4.3.3;1.-.-.-;1.1.1.184;2.3.2.27;5.3.3.8;3.4.21.-;2.6.1.44;5.3.3.21", "go_molecular_function": "GO:0005504 fatty acid binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0003997 acyl-CoA oxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0006629 lipid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0009062 fatty acid catabolic process;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7KML2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KPA5-1", "uniprot_id": "SPO11_DROME", "mass": 37064.0, "length": 331, "protein_name": "Meiotic recombination protein W68", "gene_name": "mei-W68", "organism": "Fruit fly", "refseq_name": "meiotic W68", "refseq_ac": "NP_995901", "gene_names_uniprotkb": "mei-W68; CG7753", "gene_names_refseq": "CG30132; CG7753; Dmel\\CG7753; Mei-W68; Mei-w68; MeiW68; SPO11; Spo-11; Spo11; W68; l(2)k05603; mei W-68; mei-W68; mei-w68; meiW68; mei; spo11", "protein_names_uniprotkb": "Meiotic recombination protein W68; 5.6.2.2; SPO11 protein homolog", "protein_names_refseq": "CG7753-PA; mei-W68-PA; meiotic W68", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7753)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;9744869", "class_list": "", "function": "DNA endonuclease, which specifically mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:9744869). SPO11 covalently attaches itself to the 5' DNA strand during DSB formation and each strand is cleaved by a composite active site assembled at the interface of two SPO11 monomers, with the two cleavages staggered to produce a two-nucleotide 5' overhang (By similarity). SPO11 cleavage site selection is driven by a mild sequence bias and a preference for bendable and underwound DNA (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000228 nuclear chromosome", "go_biological_process": "GO:0042140 late meiotic recombination nodule assembly;GO:0048477 oogenesis;GO:0042138 meiotic DNA double-strand break formation;GO:0006265 DNA topological change;GO:0000706 meiotic DNA double-strand break processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7KPA5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KR10-1", "uniprot_id": "CCD1D_DROME", "mass": 60275.0, "length": 521, "protein_name": "Probable cytochrome P450 12d1 distal, mitochondrial", "gene_name": "Cyp12d1-d", "organism": "Fruit fly", "refseq_name": "cytochrome P450 12d1 distal", "refseq_ac": "NP_995812", "gene_names_uniprotkb": "Cyp12d1-d; CG33503; Cyp12d1", "gene_names_refseq": "12D1; 12d1; CG18239; CG18240; CG33503; CT26082; CYP12A2; CYP12D1; CYP12d1-d; Cyp 12d1; Cyp12d1-d; Cyp12d1; Cyp12d2; Cyp12d; Dmel\\CG33503; cyp12d1-d; cyp12d1", "protein_names_uniprotkb": "Probable cytochrome P450 12d1 distal, mitochondrial; 1.14.-.-; CYPXIID1", "protein_names_refseq": "CG33503-PA; Cyp12d1-d-PA; cytochrome P450 12d1 distal; cytochrome P450-12d1; cytochrome P450", "tax_id": 7227, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); infantile hypercalcemia 1 (Disease Ontology:DOID:0061136); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); gestational diabetes (Disease Ontology:DOID:11714); lung cancer (Disease Ontology:DOID:1324); extrahepatic cholestasis (Disease Ontology:DOID:13619); alcohol use disorder (Disease Ontology:DOID:1574); rectum cancer (Disease Ontology:DOID:1993); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); ovary adenocarcinoma (Disease Ontology:DOID:3713); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cerebrotendinous xanthomatosis (Disease Ontology:DOID:4810); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); lung small cell carcinoma (Disease Ontology:DOID:5409); ulcerative colitis (Disease Ontology:DOID:8577); Wilson disease (Disease Ontology:DOID:893); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG33503)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15663776", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9UNB6;Q95RF5", "ec_number_list": "", "go_molecular_function": "GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0042369 vitamin D catabolic process;GO:0017085 response to insecticide;GO:0046680 response to DDT", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7KR10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KT91-1", "uniprot_id": "C3390_DROME", "mass": 108291.0, "length": 948, "protein_name": "Non-lysosomal glucosylceramidase", "gene_name": "CG7469; Dmel\\CG33090", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_788055", "gene_names_uniprotkb": "CG7469; Dmel\\CG33090; BG:DS01068.2; CG15287; CG31837; CG33090; CG7469; Dmel\\CG33090; Dmel_CG33090", "gene_names_refseq": "BG:DS01068.2; CG15287; CG31837; CG33090; CG7469; Dmel\\CG33090", "protein_names_uniprotkb": "Non-lysosomal glucosylceramidase; 3.2.1.45; NLGase", "protein_names_refseq": "CG33090-PB; glucosylceramidase; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "hereditary spastic paraplegia 46 (Disease Ontology:DOID:0110798)", "pathway": " (dme:Dmel_CG33090); (R-DME-9840310)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide., [UniProtKB]; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B5RIG1;Q29R22;Q95TX3", "ec_number_list": "3.2.1.45", "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0046527 glucosyltransferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0005975 carbohydrate metabolic process;GO:0008206 bile acid metabolic process;GO:0016139 glycoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7KT91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7KV12-1", "uniprot_id": "STEL1_DROME", "mass": 19525.0, "length": 172, "protein_name": "Stellate protein CG33236/CG33240/CG33244/CG33245", "gene_name": "Ste:CG33236; Ste:CG33240; Ste:CG33244; Ste:CG33245", "organism": "Fruit fly", "refseq_name": "Ste:CG33245", "refseq_ac": "NP_996423", "gene_names_uniprotkb": "Ste:CG33236; Ste:CG33240; Ste:CG33244; Ste:CG33245; CG33236; CG33240; CG33244; CG33245", "gene_names_refseq": "CG32605; CG33245; Dmel\\CG33245; Ste:CG33245", "protein_names_uniprotkb": "Stellate protein CG33236/CG33240/CG33244/CG33245", "protein_names_refseq": "CG33245-PB; Ste:CG33245-PB; Ste:CG33245", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33236); (dme:Dmel_CG33240); (dme:Dmel_CG33244); (dme:Dmel_CG33245)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;11470406;11513298;12537572;1689686;7597082", "class_list": "", "function": "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P15021;Q7KV16", "ec_number_list": "", "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7KV12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7YZH1-1", "uniprot_id": "RNO_DROME", "mass": 347626.0, "length": 3241, "protein_name": "PHD finger protein rhinoceros", "gene_name": "rno", "organism": "Fruit fly", "refseq_name": "rhinoceros, isoform D", "refseq_ac": "NP_001246528", "gene_names_uniprotkb": "rno; CG7036", "gene_names_refseq": "CG7036; Dmel\\CG7036; rno", "protein_names_uniprotkb": "PHD finger protein rhinoceros", "protein_names_refseq": "CG7036-PD; rhinoceros, isoform D; rhinoceros; rno-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7036)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;14704181;18327897", "class_list": "", "function": "May function as a negative regulator of the EGFR/Ras/MAPK signaling pathway during eye development., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "M9NDD8;Q9W0U2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042051 compound eye photoreceptor development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7YZH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7Z020-4", "uniprot_id": "TRPA1_DROME", "mass": 135158.0, "length": 1197, "protein_name": "Transient receptor potential cation channel subfamily A member 1", "gene_name": "TrpA1", "organism": "Fruit fly", "refseq_name": "transient receptor potential cation channel A1, isoform J", "refseq_ac": "NP_001097554", "gene_names_uniprotkb": "TrpA1; Anktm1; CG5751", "gene_names_refseq": "ANKTM1; Anktm1; CG5751; CG5761; CT18073; DmTRPA1; Dmel\\CG5751; TRPA1; TRPA; TrPA1; Trp1A; TrpA1; TrpA; Trpa1; Trp; dANKTM1; dTRPA1; dTRPA; dTrpA1; dTrpA; dmTRPA1; dtrpA1; trpA1; trpa1", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; dANKTM1; dTRPA1", "protein_names_refseq": "CG5751-PJ; TrPA1; TrpA1-PJ; dTRPA1; transient receptor potential A 1; transient receptor potential A1; transient receptor potential cation channel A1 ortholog; transient receptor potential cation channel A1, isoform J; transient-receptor-potential A1", "tax_id": 7227, "disease": "overactive bladder syndrome (Disease Ontology:DOID:0070355); familial episodic pain syndrome 1 (Disease Ontology:DOID:0111729); asthma (Disease Ontology:DOID:2841); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dme:Dmel_CG5751); (R-DME-3295583)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;12815418;15681611", "class_list": "", "function": "Essential for thermotaxis by sensing environmental temperature. Receptor-activated non-selective cation channel involved in detection of sensations such as temperature. Involved in heat nociception by being activated by warm temperature of about 24-29 degrees Celsius., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A8JNP0;Q9VSQ9", "ec_number_list": "", "go_molecular_function": "GO:0097604 temperature-gated cation channel activity;GO:0005262 calcium channel activity;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0005261 monoatomic cation channel activity;GO:0015278 intracellularly gated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0023041 neuronal signal transduction;GO:0006816 calcium ion transport;GO:0034605 cellular response to heat;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7Z020-4", "record_type": "protein" }, { "uniprot_canonical_ac": "Q868Z9-1", "uniprot_id": "PPN_DROME", "mass": 313035.0, "length": 2898, "protein_name": "Papilin", "gene_name": "Ppn", "organism": "Fruit fly", "refseq_name": "papilin, isoform C", "refseq_ac": "NP_001163760", "gene_names_uniprotkb": "Ppn; CG33103", "gene_names_refseq": "CG1540; CG18436; CG33103; CT3186; CT41988; Dmel\\CG33103; Ppn; ppl; ppn", "protein_names_uniprotkb": "Papilin", "protein_names_refseq": "CG33103-PC; Ppn-PC; lacunin-like; papilin precursor; papilin, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33103)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;11076767;12537572;12666201;17893096;3320045;33925313;40245499", "class_list": "", "function": "Essential extracellular matrix (ECM) protein that influences cell rearrangements. May act by modulating metalloproteinases action during organogenesis. Able to non-competitively inhibit procollagen N-proteinase, an ADAMTS metalloproteinase., [UniProtKB, PubMed]", "predicted_glycosites": 23, "predicted_n_glycosites": 19, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "E1JJ05;E1JJ06;Q6NP04;Q7KRX2;Q869A0;Q9GQR0;Q9VAV3;Q9VAV4", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0005604 basement membrane", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q868Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q86B50-1", "uniprot_id": "Q86B50_DROME", "mass": 31662.0, "length": 279, "protein_name": "Meiotic 217", "gene_name": "mei-217", "organism": "Fruit fly", "refseq_name": "meiotic 217", "refseq_ac": "NP_001027069", "gene_names_uniprotkb": "mei-217; CG33067; CG33935; Dmel\\CG33935; Dmel_CG33935; Mei-217", "gene_names_refseq": "CG33067; CG33935; Dmel\\CG33935; Mei-217; mei-217", "protein_names_uniprotkb": "Meiotic 217", "protein_names_refseq": "CG33935-PC; mei-217-PC; meiotic 217", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33935)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007143 female meiotic nuclear division;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q86B50-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q86B61-1", "uniprot_id": "TBH1_DROME", "mass": 77729.0, "length": 670, "protein_name": "Tyramine beta-hydroxylase", "gene_name": "Tbh", "organism": "Fruit fly", "refseq_name": "tyramine beta hydroxylase, isoform C", "refseq_ac": "NP_001284996", "gene_names_uniprotkb": "Tbh; CG1543; DBH; Dbh; Dmel\\CG1543; Dmel_CG1543; T beta h; TBH; TBetaH; TBetah; TBh; TbH; TbetaH; TbetaM; Tbetah; tbetah; tbh", "gene_names_refseq": "CG1543; DBH; Dbh; Dmel\\CG1543; T beta h; TBH; TBetaH; TBetah; TBh; TbH; TbetaH; TbetaM; Tbetah; Tbh; tbetah; tbh", "protein_names_uniprotkb": "Tyramine beta-hydroxylase; 1.14.17.-; TbetaM; Tyramine beta-monooxygenase", "protein_names_refseq": "CG1543-PC; Tbh-PC; Tyrosine-beta-hydroxylase; dopamine beta hydroxylase; tyramine beta hydroxylase, isoform C; tyramine beta hydroxylase; tyramine beta-hydroxylase; tyramine beta-monooxygenase; tyramine betahydroxylase; tyramine-beta-hydroxylase; tyroside beta-hydroxylase; tyrosine beta hydroxylase", "tax_id": 7227, "disease": "dopamine beta-hydroxylase deficiency (Disease Ontology:DOID:0090145); migraine with aura (Disease Ontology:DOID:10024); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (dme:Dmel_CG1543); (R-DME-209905)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14623230;14978721;16110336;16376104;17569856;17569867;23142736;25187989;25589440;26109356;26109357;37309249;8656284", "class_list": "", "function": "Catalyzes the hydroxylation of tyramine into octopamine, a neurotransmitter involved in ovulation and locomotion (PubMed:14623230, PubMed:14978721, PubMed:16376104, PubMed:8656284). Functions in an amine-mediated Bacc-dependent signaling pathway that negatively regulates acute ethanol sensitivity (PubMed:23142736). Involved in facilitation of nociceptive escape behavior in response to potentially damaging stimuli, such as high temperatures (PubMed:37309249)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1EC33;Q24549", "ec_number_list": "1.14.17.-;1.14.17.1", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004500 dopamine beta-monooxygenase activity;GO:0004836 tyramine-beta hydroxylase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030667 secretory granule membrane;GO:0016020 membrane", "go_biological_process": "GO:0008049 male courtship behavior;GO:0002121 inter-male aggressive behavior;GO:0007612 learning;GO:0007613 memory;GO:0048149 behavioral response to ethanol", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q86B61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q86BS6-1", "uniprot_id": "MET2_DROME", "mass": 38132.0, "length": 325, "protein_name": "tRNA N(3)-methylcytidine methyltransferase Mettl2", "gene_name": "Mettl2", "organism": "Fruit fly", "refseq_name": "methyltransferase like 2, isoform B", "refseq_ac": "NP_647636", "gene_names_uniprotkb": "Mettl2; CG13929; metl", "gene_names_refseq": "CG13929; Dmel\\CG13929; METTL2A; METTL2B; Metl; Mettl2; anon-EST:Posey109; metl", "protein_names_uniprotkb": "tRNA N(3)-methylcytidine methyltransferase Mettl2; 2.1.1.-; Methyltransferase-like protein 2", "protein_names_refseq": "CG13929-PB; Mettl2-PB; methyltransferase like 2, isoform B; methyltransferase-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13929)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11738826;12537569;12537572", "class_list": "", "function": "Probable methyltransferase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q960S9;Q9W0C0", "ec_number_list": "", "go_molecular_function": "GO:0016427 tRNA (cytidine) methyltransferase activity;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q86BS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q86BY9-1", "uniprot_id": "RIG_DROME", "mass": 137829.0, "length": 1235, "protein_name": "Gem-associated protein 5", "gene_name": "rig", "organism": "Fruit fly", "refseq_name": "rigor mortis", "refseq_ac": "NP_611499", "gene_names_uniprotkb": "rig; CG30149; Gem5", "gene_names_refseq": "CG11171; CG13440; CG30149; Dmel\\CG30149; Gem5; Gemin5; Rig; anon-SAGE:Wang-132; l(2)05056; rig", "protein_names_uniprotkb": "Gem-associated protein 5; Gemin5; Protein rigor mortis", "protein_names_refseq": "CG30149-PB; Gemin5; anon-SAGE:Wang-132; rig-PB; rigor mortis", "tax_id": 7227, "disease": "neurodevelopmental disorder with cerebellar atrophy and motor dysfunction (Disease Ontology:DOID:0070443)", "pathway": " (dme:Dmel_CG30149)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;14645129;18327897;20452345;24391840;26098872;30563832", "class_list": "", "function": "Component of the survival motor neuron (SMN) complex that catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:30563832). Nuclear receptor cofactor for the ecdysone-regulated processes of molting and puparium formation (PubMed:14645129). Acts downstream from ecdysone biosynthesis and release to control the expression of specific ecdysone-regulated genes such as Eip74EF (E74) (PubMed:14645129). Essential in muscle and neuronal tissues for motor function, including climbing ability and flight (PubMed:24391840)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86P78;Q9V957", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032797 SMN complex;GO:0097504 Gemini of Cajal bodies;GO:0071254 cytoplasmic U snRNP body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008344 adult locomotory behavior;GO:0000387 spliceosomal snRNP assembly;GO:0007591 molting cycle, chitin-based cuticle;GO:0007629 flight behavior", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q86BY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q86P48-1", "uniprot_id": "ATBP_DROME", "mass": 42598.0, "length": 388, "protein_name": "AT-rich binding protein", "gene_name": "ATbp", "organism": "Fruit fly", "refseq_name": "(A+T)-stretch binding protein", "refseq_ac": "NP_001104481", "gene_names_uniprotkb": "ATbp; CG17172", "gene_names_refseq": "ATBP; ATbp; CG17172; CG40145; Dmel\\CG17172", "protein_names_uniprotkb": "AT-rich binding protein; (A+T)-stretch binding protein", "protein_names_refseq": "(A+T)-stretch binding protein; ATbp-PB; CG17172-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17172)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11841500;12537572", "class_list": "", "function": "May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions. Binds to AT rich DNA., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q86P48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IMP6-1", "uniprot_id": "SPT2_DROME", "mass": 65701.0, "length": 581, "protein_name": "Protein SPT2 homolog", "gene_name": "CG5815", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": "NP_651537", "gene_names_uniprotkb": "CG5815", "gene_names_refseq": "BcDNA:GH07089; BcDNA:GH07346; CG5815; Dmel\\CG5815; Spt2", "protein_names_uniprotkb": "Protein SPT2 homolog", "protein_names_refseq": "CG5815-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5815)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYF3;Q9Y132", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IMP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IMU4-1", "uniprot_id": "PNPH_DROME", "mass": 32132.0, "length": 290, "protein_name": "Purine nucleoside phosphorylase", "gene_name": "CG31115", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_733068", "gene_names_uniprotkb": "CG31115", "gene_names_refseq": "CG31115; Dmel\\CG31115", "protein_names_uniprotkb": "Purine nucleoside phosphorylase; 2.4.2.1; PNP", "protein_names_refseq": "CG31115-PB; uncharacterized protein", "tax_id": 7227, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); diaphyseal medullary stenosis with malignant fibrous histiocytoma (Disease Ontology:DOID:0080664); pancreatic cancer (Disease Ontology:DOID:1793); common bile duct neoplasm (Disease Ontology:DOID:4608)", "pathway": " (dme:Dmel_CG31115)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Purine nucleoside phosphorylase involved in purine salvage., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.1", "go_molecular_function": "GO:0017061 S-methyl-5-thioadenosine phosphorylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006166 purine ribonucleoside salvage;GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8IMU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IMZ9-1", "uniprot_id": "WFS1_DROME", "mass": 96789.0, "length": 853, "protein_name": "Wolframin", "gene_name": "wfs1", "organism": "Fruit fly", "refseq_name": "wolfram syndrome 1, isoform C", "refseq_ac": "NP_001189267", "gene_names_uniprotkb": "wfs1; CG4917", "gene_names_refseq": "CG4917; Dmel\\CG4917; WFS1; wfs1", "protein_names_uniprotkb": "Wolframin", "protein_names_refseq": "CG4917-PC; wfs1-PC; wolfram syndrome 1, isoform C", "tax_id": 7227, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); autosomal dominant Wolfram syndrome (Disease Ontology:DOID:0080584); cataract 41 (Disease Ontology:DOID:0110241); autosomal dominant nonsyndromic deafness 6 (Disease Ontology:DOID:0110584); Wolfram syndrome 1 (Disease Ontology:DOID:0110629); optic atrophy 1 (Disease Ontology:DOID:0111441); sensorineural hearing loss (Disease Ontology:DOID:10003); glucose intolerance (Disease Ontology:DOID:10603); Wolfram syndrome (Disease Ontology:DOID:10632); post-traumatic stress disorder (Disease Ontology:DOID:2055); optic atrophy (Disease Ontology:DOID:5723); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG4917); (R-DME-381426); (R-DME-8957275)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;29357349", "class_list": "", "function": "Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). In neurons and glial cells, has a role in maintaining neuronal function and integrity during aging (PubMed:29357349)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4JDG5;Q8MS19", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0010629 negative regulation of gene expression;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8IMZ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IN23-1", "uniprot_id": "GR93B_DROME", "mass": 46152.0, "length": 395, "protein_name": "Putative gustatory receptor 93b", "gene_name": "Gr93b", "organism": "Fruit fly", "refseq_name": "gustatory receptor 93b", "refseq_ac": "NP_732664", "gene_names_uniprotkb": "Gr93b; CG31336; GR93F.2", "gene_names_refseq": "93F.2; CG13411; CG31336; Dmel\\CG31336; GR93F.2; GR93b; Gr93F2; Gr93b", "protein_names_uniprotkb": "Putative gustatory receptor 93b", "protein_names_refseq": "CG31336-PB; Gr93b-PB; gustatory receptor 93F.2; gustatory receptor 93b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31336)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10710312;10731132;11516643;12537572;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0007635 chemosensory behavior;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8IN23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8INX3-1", "uniprot_id": "TIPIN_DROME", "mass": 34122.0, "length": 307, "protein_name": "Protein TIPIN homolog", "gene_name": "CG10336", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": "NP_609895", "gene_names_uniprotkb": "CG10336", "gene_names_refseq": "CG10336; Dmel\\CG10336", "protein_names_uniprotkb": "Protein TIPIN homolog; CSM3 homolog", "protein_names_refseq": "CG10336-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10336)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;12975318", "class_list": "", "function": "Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VJ65", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0008284 positive regulation of cell population proliferation;GO:0051301 cell division;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0044770 cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8INX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IQ27-1", "uniprot_id": "UBP2_DROME", "mass": 101704.0, "length": 938, "protein_name": "Ubiquitin carboxyl-terminal hydrolase Usp2", "gene_name": "Usp2", "organism": "Fruit fly", "refseq_name": "ubiquitin specific protease 2, isoform F", "refseq_ac": "NP_001245799", "gene_names_uniprotkb": "Usp2; CG14619; Dmel\\CG14619; Dmel_CG14619; Q9VR54; USP2; dUsp2", "gene_names_refseq": "CG14619; Dmel\\CG14619; Q9VR54; USP2; Usp2; dUsp2", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase Usp2; 3.4.19.12; Ubiquitin specific protease 2", "protein_names_refseq": "CG14619-PF; Usp2-PF; ubiquitin specific protease 2, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14619); (R-DME-5689880)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;24026097;25027767;25589440;26109356;26109357;26756164;40245499", "class_list": "", "function": "Hydrolase that deubiquitinates polyubiquitinated target proteins (PubMed:25027767). Required for preventing the activation of the Toll signaling cascades under unchallenged conditions (PubMed:25027767). Essential for bodily calcium homeostasis (PubMed:26756164)., [UniProtKB, PubMed, PubMed]; Required for preventing the activation of the immune deficiency (Imd) signaling cascade under unchallenged conditions. Regulates the Imd pathway by specifically removing 'Lys-48'-linked ubiquitin from imd. Also promotes imd degradation probably by binding to imd and enhancing its association with the proteasome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T9E4;Q9VR54", "ec_number_list": "3.4.19.12;2.7.11.25", "go_molecular_function": "GO:0046872 metal ion binding;GO:0070628 proteasome binding;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0045087 innate immune response;GO:0051926 negative regulation of calcium ion transport;GO:1901800 positive regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8IQ27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IQ56-1", "uniprot_id": "TMM11_DROME", "mass": 20333.0, "length": 182, "protein_name": "Transmembrane protein 11 homolog, mitochondrial", "gene_name": "Pmi", "organism": "Fruit fly", "refseq_name": "Pmi, isoform D", "refseq_ac": "NP_001027109", "gene_names_uniprotkb": "Pmi; CG33718", "gene_names_refseq": "CG32912; CG33718; CG5523; Dmel\\CG33718; PMI; Pmi", "protein_names_uniprotkb": "Transmembrane protein 11 homolog, mitochondrial; Protein PMI", "protein_names_refseq": "CG33718-PD; Pmi, isoform D; Pmi-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33718)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11106397;12537572;18327897;21274005", "class_list": "", "function": "Plays a role in mitochondrial morphogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VRP7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0007007 inner mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8IQ56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IQ72-1", "uniprot_id": "GL65A_DROME", "mass": 43218.0, "length": 371, "protein_name": "Gustatory receptor-like 65a", "gene_name": "Grl65a", "organism": "Fruit fly", "refseq_name": "gustatory receptor-like 65a", "refseq_ac": "NP_729182", "gene_names_uniprotkb": "Grl65a; CG32395", "gene_names_refseq": "65C.1; CG32395; Dmel\\CG32395; GR65C.1; Gr65C1; Gr65a; Grl65a", "protein_names_uniprotkb": "Gustatory receptor-like 65a", "protein_names_refseq": "CG32395-PB; Gr65a; Grl65a-PB; gustatory receptor 65C.1; gustatory receptor-like 65a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32395)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10710312;10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IQ72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IQF1-1", "uniprot_id": "MOCS1_DROME", "mass": 63258.0, "length": 565, "protein_name": "Molybdenum cofactor biosynthesis protein 1", "gene_name": "Mocs1", "organism": "Fruit fly", "refseq_name": "molybdenum cofactor synthesis 1, isoform C", "refseq_ac": "NP_788494", "gene_names_uniprotkb": "Mocs1; CG33048; lxd", "gene_names_refseq": "CG33048; CG7858; Dmel\\CG33048; MOCS1A; MOCS1B; MOCSI; Mocs1A-B; Mocs1A; Mocs1B; Mocs1; MocsI; Mosc1A+Mosc1B; lxd; mocsI; pfs", "protein_names_uniprotkb": "Molybdenum cofactor biosynthesis protein 1; MOCS1A; MOCS1B; Molybdenum cofactor biosynthesis protein A; Molybdenum cofactor biosynthesis protein C", "protein_names_refseq": "CG33048-PC; Mocs1-PC; low xanthine dehydrogenase; molybdenum cofactor synthesis 1 ortholog; molybdenum cofactor synthesis 1, isoform C; peacefulness", "tax_id": 7227, "disease": "molybdenum cofactor deficiency type A (Disease Ontology:DOID:0111164)", "pathway": " (dme:Dmel_CG33048); (R-DME-947581)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;10917590;12537572", "class_list": "", "function": "Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NIG3;Q9NIG4;Q9VTE4", "ec_number_list": "4.1.99.22;4.6.1.17", "go_molecular_function": "GO:0061798 GTP 3',8'-cyclase activity;GO:0061799 cyclic pyranopterin monophosphate synthase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IQF1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IRE4-1", "uniprot_id": "TRM5_DROME", "mass": 53074.0, "length": 457, "protein_name": "tRNA (guanine(37)-N(1))-methyltransferase", "gene_name": "CG32281", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_728821", "gene_names_uniprotkb": "CG32281", "gene_names_refseq": "CG12032; CG32281; Dmel\\CG32281", "protein_names_uniprotkb": "tRNA (guanine(37)-N(1))-methyltransferase; 2.1.1.228; M1G-methyltransferase; tRNA [GM37] methyltransferase; tRNA methyltransferase 5 homolog", "protein_names_refseq": "CG32281-PA; uncharacterized protein", "tax_id": 7227, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); combined oxidative phosphorylation deficiency 26 (Disease Ontology:DOID:0111490); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); hypercalcemia (Disease Ontology:DOID:12678); lactic acidosis (Disease Ontology:DOID:3650); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (dme:Dmel_CG32281)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.228", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0002939 tRNA N1-guanine methylation;GO:0070901 mitochondrial tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8IRE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8IRJ8-2", "uniprot_id": "THOC7_DROME", "mass": 33052.0, "length": 288, "protein_name": "THO complex protein 7", "gene_name": "thoc7", "organism": "Fruit fly", "refseq_name": "thoc7, isoform B", "refseq_ac": "NP_612011", "gene_names_uniprotkb": "thoc7; CG17143", "gene_names_refseq": "CG17143; Dmel\\CG17143; THOC7; Thoc7; thoc7", "protein_names_uniprotkb": "THO complex protein 7", "protein_names_refseq": "CG17143-PB; thoc7, isoform B; thoc7-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17143); (R-DME-159236)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;15133499;18327897", "class_list": "", "function": "The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1WWD6;Q9W0T8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0034587 piRNA processing;GO:0031990 mRNA export from nucleus in response to heat stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8IRJ8-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MKK4-1", "uniprot_id": "TRE12_DROME", "mass": 53088.0, "length": 488, "protein_name": "Trehalose transporter 1-like protein", "gene_name": "Tret1l", "organism": "Fruit fly", "refseq_name": "trehalose transporter 1-2", "refseq_ac": "NP_610694", "gene_names_uniprotkb": "Tret1l; CG8234; Tret1-2", "gene_names_refseq": "CG8234; DmTret1-2; Dmel\\CG8234; Tret1-2", "protein_names_uniprotkb": "Trehalose transporter 1-like protein; DmTret1-2; Facilitated trehalose transporter Tret1-2 homolog", "protein_names_refseq": "CG8234-PA; Tret1-2-PA; trehalose transporter 1-2; trehalose transporter", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8234); (R-DME-189200)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;20035867;26235423", "class_list": "", "function": "Fails to transport trehalose., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1Z8N4", "ec_number_list": "", "go_molecular_function": "GO:0051119 sugar transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8MKK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MKN0-1", "uniprot_id": "COQ9_DROME", "mass": 36343.0, "length": 326, "protein_name": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "gene_name": "Coq9", "organism": "Fruit fly", "refseq_name": "coenzyme Q9", "refseq_ac": "NP_724594", "gene_names_uniprotkb": "Coq9; CG30493", "gene_names_refseq": "CG1952; CG30493; Coq9; Dmel\\CG30493", "protein_names_uniprotkb": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "protein_names_refseq": "CG30493-PB; Coq9-PB; coenzyme Q9", "tax_id": 7227, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 5 (Disease Ontology:DOID:0070242)", "pathway": " (dme:Dmel_CG30493); (R-DME-2142789)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T8R0", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8MKN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MS59-1", "uniprot_id": "WAT_DROME", "mass": 59515.0, "length": 517, "protein_name": "Fatty acyl-CoA reductase wat", "gene_name": "wat", "organism": "Fruit fly", "refseq_name": "waterproof", "refseq_ac": "NP_651652", "gene_names_uniprotkb": "wat; CG1443", "gene_names_refseq": "CG1443; Dmel\\CG1443; FAR1; Wat; wat", "protein_names_uniprotkb": "Fatty acyl-CoA reductase wat; 1.2.1.84; Protein waterproof", "protein_names_refseq": "CG1443-PA; wat-PA; waterproof", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1443); (R-DME-9640463)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;24183938", "class_list": "", "function": "Catalyzes the reduction of saturated fatty acyl-CoA to fatty alcohols. The preferred substrates are C24:0 and C26:0. Necessary for the final stages of tracheal maturation, to facilitate the transition from water-filled to gas-filled tubes. May help to maintain the integrity of the outer hydrophobic envelope of the trachea., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VAR3", "ec_number_list": "1.2.1.84", "go_molecular_function": "GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity;GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:0035002 liquid clearance, open tracheal system;GO:0035149 lumen formation, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8MS59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MSV2-5", "uniprot_id": "SHEP_DROME", "mass": 62175.0, "length": 590, "protein_name": "Protein alan shepard", "gene_name": "shep", "organism": "Fruit fly", "refseq_name": "alan shepard, isoform E", "refseq_ac": "NP_001163350", "gene_names_uniprotkb": "shep; CG32423", "gene_names_refseq": "BcDNA:LD40028; BcDNA:RH63980; CG10647; CG10649; CG10668; CG32423; Dmel\\CG32423; Shep; alan-shepard; alan; anon-EST:Posey83; anon-WO0118547.198; anon-WO0172774.41; cg10668; shep", "protein_names_uniprotkb": "Protein alan shepard", "protein_names_refseq": "CG32423-PE; alan shepard, isoform E; alan shepard; shep-PE", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32423)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;16594976;17372656;18327897;40245499", "class_list": "", "function": "Has a role in the perception of gravity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E1JID7;M9ND50;M9PEP6;Q7KU60;Q86BS4;Q8SWY6;Q95S20;Q95S52;Q9VRK3;Q9VRK5", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0016322 neuron remodeling;GO:0034976 response to endoplasmic reticulum stress;GO:0009629 response to gravity;GO:0008050 female courtship behavior", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8MSV2-5", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MSY4-1", "uniprot_id": "VPS51_DROME", "mass": 83938.0, "length": 740, "protein_name": "Vacuolar protein sorting-associated protein 51 homolog", "gene_name": "Vps51", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 51", "refseq_ac": "NP_611363", "gene_names_uniprotkb": "Vps51; CG15087", "gene_names_refseq": "CG15087; Dmel\\CG15087; Vps51", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 51 homolog; Protein fat-free homolog", "protein_names_refseq": "CG15087-PA; Vps51-PA; vacuolar protein sorting 51", "tax_id": 7227, "disease": "pontocerebellar hypoplasia type 13 (Disease Ontology:DOID:0112332)", "pathway": " (dme:Dmel_CG15087); (R-DME-6811440)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May act as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V8L5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0007030 Golgi organization;GO:0032456 endocytic recycling;GO:0048193 Golgi vesicle transport;GO:0007041 lysosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8MSY4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8MT80-1", "uniprot_id": "PIGZ_DROME", "mass": 80217.0, "length": 696, "protein_name": "GPI mannosyltransferase 4", "gene_name": "PIG-Z", "organism": "Fruit fly", "refseq_name": "phosphatidylinositol glycan anchor biosynthesis class Z", "refseq_ac": "NP_001286840", "gene_names_uniprotkb": "PIG-Z; CG45068", "gene_names_refseq": "CG3419; CG45068; Dmel\\CG45068; PIG-Z; PIGZ", "protein_names_uniprotkb": "GPI mannosyltransferase 4; 2.4.1.-; GPI mannosyltransferase IV; GPI-MT-IV; Phosphatidylinositol glycan anchor biosynthesis protein class Z", "protein_names_refseq": "CG45068-PA; PIG-Z-PA; phosphatidylinositol glycan anchor biosynthesis class Z", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG45068); (R-DME-162710)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LGH6;Q9W176", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0120565 dol-P-Man:Man(3)GlcN-acyl-PI alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8MT80-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8ST83-1", "uniprot_id": "PHO_DROME", "mass": 58224.0, "length": 520, "protein_name": "Polycomb protein PHO", "gene_name": "pho", "organism": "Fruit fly", "refseq_name": "pleiohomeotic, isoform A", "refseq_ac": "NP_524630", "gene_names_uniprotkb": "pho; CG17743", "gene_names_refseq": "CG17743; Dmel\\CG17743; PHO/YY1; PHO; Pho; Ph; YY1; dYY1; l(4)102EFc; l(4)29; l(4)BU-2; l(4)OC-1; l(4)pho; pho", "protein_names_uniprotkb": "Polycomb protein PHO; Protein pleiohomeotic; Transcription factor YY1 homolog", "protein_names_refseq": "CG17743-PA; PHO; peiohomeotic; pho-PA; pleihomeotic; pleiohomeotic, isoform A; pleiohomeotic; pleohomeotic; polyhomeotic", "tax_id": 7227, "disease": "pleuropulmonary blastoma (Disease Ontology:DOID:4769); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG17743); (R-DME-5689603); (R-DME-5696394); (R-DME-9018519)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10433918;10731132;11092813;11581156;11778050;12537569;12537572;14668375;16618800;27918560;9651589", "class_list": "", "function": "Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression., [UniProtKB, PubMed, PubMed]; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V138;O76247;Q6W466;Q6W467;Q6W470;Q6W480;Q6W485;Q9V4A3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0031011 Ino80 complex;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8ST83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SXD4-1", "uniprot_id": "MIDN_DROME", "mass": 112184.0, "length": 1122, "protein_name": "Midnolin homolog", "gene_name": "stx", "organism": "Fruit fly", "refseq_name": "stuxnet, isoform B", "refseq_ac": "NP_001259426", "gene_names_uniprotkb": "stx; CG32676", "gene_names_refseq": "CG32676; CG9725; CG9732; Dmel\\CG32676; stx", "protein_names_uniprotkb": "Midnolin homolog; Protein stuxnet", "protein_names_refseq": "CG32676-PB; stuxnet, isoform B; stx-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32676)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;27326929", "class_list": "", "function": "Facilitates ubiquitin-independent proteasomal degradation of polycomb protein Pc by interacting directly with the proteasome and recruiting Pc to it., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9W2R7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8SXD4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SXQ7-1", "uniprot_id": "PGPLF_DROME", "mass": 41966.0, "length": 369, "protein_name": "Peptidoglycan-recognition protein LF", "gene_name": "PGRP-LF", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein LF", "refseq_ac": "NP_648299", "gene_names_uniprotkb": "PGRP-LF; CG4437", "gene_names_refseq": "CG4437; Dmel\\CG4437; PGRP-LF; PGRP-like; PGRPLF; PGRP; anon-WO0118547.581; pgrp-lf", "protein_names_uniprotkb": "Peptidoglycan-recognition protein LF; PGRP-like protein", "protein_names_refseq": "CG4437-PA; PGRP-LF-PA; PRGP-like; Peptidoglycan-recognition protein-LF; peptidoglycan recognition protein LF; peptidoglycan recognition protein-LF", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4437); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12032070;12537569;12537572;12777387", "class_list": "", "function": "Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VSW0", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0098542 defense response to other organism;GO:0006955 immune response;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8SXQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SYD0-1", "uniprot_id": "TTC19_DROME", "mass": 42060.0, "length": 369, "protein_name": "Tetratricopeptide repeat protein 19 homolog, mitochondrial", "gene_name": "Ttc19", "organism": "Fruit fly", "refseq_name": "tetratricopeptide repeat domain 19", "refseq_ac": "NP_609934", "gene_names_uniprotkb": "Ttc19; CG15173", "gene_names_refseq": "CG15173; Dmel\\CG15173; TTC19; Ttc19; cg15173; dTTC19", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 19 homolog, mitochondrial", "protein_names_refseq": "CG15173-PA; Ttc19-PA; tetratricopeptide repeat domain 19", "tax_id": 7227, "disease": "mitochondrial complex III deficiency nuclear type 2 (Disease Ontology:DOID:0060351)", "pathway": " (dme:Dmel_CG15173); (R-DME-9865881)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;21278747", "class_list": "", "function": "Required for mitochondrial complex III formation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VJ13", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8SYD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8SYG2-1", "uniprot_id": "CSN3_DROME", "mass": 50703.0, "length": 445, "protein_name": "COP9 signalosome complex subunit 3", "gene_name": "CSN3", "organism": "Fruit fly", "refseq_name": "COP9 signalosome subunit 3", "refseq_ac": "NP_524190", "gene_names_uniprotkb": "CSN3; CG18332", "gene_names_refseq": "CG18332; CH3; CSN3; Csn3; DCH3; Dch3; Dmel\\CG18332; FBgn0027055; csn3; dCSN3", "protein_names_uniprotkb": "COP9 signalosome complex subunit 3; Dch3; Signalosome subunit 3", "protein_names_refseq": "CG18332-PA; COP9 complex homolog subunit 3; COP9 signalosome subunit 3; CSN3-PA; drosophila COP9 signalosome homolog 3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18332); (R-DME-5696394); (R-DME-6781823); (R-DME-8856825); (R-DME-8951664)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10531038;10731132;12537569;12537572;12737805", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VPA3;Q9XYW4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0050821 protein stabilization;GO:0007281 germ cell development;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0000338 protein deneddylation;GO:0048140 male germ-line cyst encapsulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8SYG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8T3X9-1", "uniprot_id": "ISCA1_DROME", "mass": 14140.0, "length": 130, "protein_name": "Iron-sulfur cluster assembly 1 homolog, mitochondrial", "gene_name": "MagR", "organism": "Fruit fly", "refseq_name": "magnetic receptor, isoform B", "refseq_ac": "NP_001259579", "gene_names_uniprotkb": "MagR; CG8198; Isca1; l(1)G0136", "gene_names_refseq": "BcDNA:AT26381; CG8198; Dmel\\CG8198; IscA1; MagR; dMagR; l(1)G0136", "protein_names_uniprotkb": "Iron-sulfur cluster assembly 1 homolog, mitochondrial; Lethal (1) G0136; Putative magnetoreceptor subunit MagR", "protein_names_refseq": "CG8198-PB; IscA1 homologue; MagR-PB; lethal (1) G0136; magnetic receptor, isoform B; magnetic receptor; magnetoreceptor", "tax_id": 7227, "disease": "multiple mitochondrial dysfunctions syndrome 5 (Disease Ontology:DOID:0080274)", "pathway": " (dme:Dmel_CG8198); (R-DME-1362409)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;22885802;26569474", "class_list": "", "function": "Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity). Required for maintenance of circadian rhythms under constant darkness (PubMed:22885802)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PJN7;Q9VXR0", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0120510 mitochondrial [4Fe-4S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation;GO:0071000 response to magnetism;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8T3X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8T8L8-1", "uniprot_id": "ALG10_DROME", "mass": 51783.0, "length": 449, "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "Alg10", "organism": "Fruit fly", "refseq_name": "ALG10 alpha-1,2-glucosyltransferase", "refseq_ac": "NP_729680", "gene_names_uniprotkb": "Alg10; CG32076", "gene_names_refseq": "Alg10; CG32076; CG7624; Dmel\\CG32076; alg10; dAlg10", "protein_names_uniprotkb": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; 2.4.1.256; Alpha-2-glucosyltransferase ALG10", "protein_names_refseq": "ALG10 alpha-1,2-glucosyltransferase; Alg10-PA; CG32076-PA; alpha 3 glucosyltransferase", "tax_id": 7227, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); long QT syndrome 2 (Disease Ontology:DOID:0110645)", "pathway": " (dme:Dmel_CG32076)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12200473;12537569;12537572", "class_list": "", "function": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQM2;Q9VTG3", "ec_number_list": "2.4.1.256", "go_molecular_function": "GO:0106073 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8T8L8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q94915-1", "uniprot_id": "REG2_DROME", "mass": 30113.0, "length": 260, "protein_name": "Rhythmically expressed gene 2 protein", "gene_name": "Reg-2", "organism": "Fruit fly", "refseq_name": "rhythmically expressed gene 2", "refseq_ac": "NP_612043", "gene_names_uniprotkb": "Reg-2; CG3200", "gene_names_refseq": "21483246; CG3200; Dmel\\CG3200; Dreg-2; Reg-2", "protein_names_uniprotkb": "Rhythmically expressed gene 2 protein; dREG-2", "protein_names_refseq": "CG3200-PA; Reg-2-PA; drosophila rhythmically expressed gene 2; rhythmically expressed gene 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3200)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;8749395", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0P6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q94915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95078-1", "uniprot_id": "CP18A_DROME", "mass": 61949.0, "length": 538, "protein_name": "Cytochrome P450 18a1", "gene_name": "Cyp18a1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 18a1, isoform B", "refseq_ac": "NP_523403", "gene_names_uniprotkb": "Cyp18a1; CG6816; CYP18; Eig17-1", "gene_names_refseq": "181H6T; 18a1; 26-hyd; CG6816; CT20826; CYP18A1-Dm; CYP18A1; CYP18; Cyp18A1; Cyp18a1; Cyp18; Cyt-P450-17C; CytP450; Dmel\\CG6816; ESTS:181H6T; Eig17-1; P-450; P450; cyp18a1; cyp18", "protein_names_uniprotkb": "Cytochrome P450 18a1; 1.14.-.-; CYPXVIIIA1", "protein_names_refseq": "CG6816-PB; Cyp18a1-PB; cytochrome P450 17C; cytochrome P450 18a1, isoform B; cytochrome P450-18a1", "tax_id": 7227, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); renal fibrosis (Disease Ontology:DOID:0050855); warfarin resistance (Disease Ontology:DOID:0080665); vitamin D-dependent rickets type 1B (Disease Ontology:DOID:0080887); traumatic brain injury (Disease Ontology:DOID:0081292); hereditary spastic paraplegia 56 (Disease Ontology:DOID:0110808); pre-eclampsia (Disease Ontology:DOID:10591); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); gestational diabetes (Disease Ontology:DOID:11714); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); extrapyramidal and movement disease (Disease Ontology:DOID:13839); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); major depressive disorder (Disease Ontology:DOID:1470); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); coronary stenosis (Disease Ontology:DOID:4248); rhinitis (Disease Ontology:DOID:4483); multiple chemical sensitivity (Disease Ontology:DOID:4661); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); end stage renal disease (Disease Ontology:DOID:783); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); neonatal abstinence syndrome (Disease Ontology:DOID:9828); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (dme:Dmel_CG6816); (R-DME-211958); (R-DME-2142816)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537572;17322555;8413299;9256362", "class_list": "", "function": "Probably involved in steroid hormones biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 52, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5AC86;A5AC96;Q0KHQ8;Q27767;Q9VWR4", "ec_number_list": "1.14.-.-;1.14.14.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0008202 steroid metabolic process;GO:0006082 organic acid metabolic process;GO:0035074 pupation;GO:0046344 ecdysteroid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q95078-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95NH6-1", "uniprot_id": "ATTC_DROME", "mass": 25535.0, "length": 241, "protein_name": "Attacin-C", "gene_name": "AttC", "organism": "Fruit fly", "refseq_name": "Attacin-C", "refseq_ac": "NP_523729", "gene_names_uniprotkb": "AttC; CG4740; IM16", "gene_names_refseq": "AttC; Attacin C; Att; CG4740; C; DIM 16; DIM-16; Dmel\\CG4740; MPAC; att C; attC; attacin c; attacin; att", "protein_names_uniprotkb": "Attacin-C; MPAC", "protein_names_refseq": "AttC-PB; Attacin-C precursor; Attacin-C; CG4740-PB; attacin C; attacinC; attackin; drosophila immune induced molecule 16", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG4740)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;11118328;11606542;12537572;14744858;16510152;18327897;9736738", "class_list": "", "function": "Has antimicrobial activity in synergy with other peptides. Strongest activity observed against E.cloacae., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8ML72;Q95NK2;Q95UA2;Q95UA3;Q95UA4;Q95UA5;Q9GPI3;Q9GPI4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0009617 response to bacterium;GO:0006959 humoral immune response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q95NH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95RU0-1", "uniprot_id": "CUE_DROME", "mass": 72623.0, "length": 644, "protein_name": "Protein cueball", "gene_name": "cue", "organism": "Fruit fly", "refseq_name": "cueball", "refseq_ac": "NP_612113", "gene_names_uniprotkb": "cue; CG12086", "gene_names_refseq": "CG12086; CT5570; Dmel\\CG12086; cue; ms(3)02509", "protein_names_uniprotkb": "Protein cueball", "protein_names_refseq": "CG12086-PA; cue-PA; cueball", "tax_id": 7227, "disease": "acute kidney failure (Disease Ontology:DOID:3021); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (dme:Dmel_CG12086); (R-DME-114608); (R-DME-1227986); (R-DME-1236394); (R-DME-1250196); (R-DME-1257604); (R-DME-1474228); (R-DME-177929); (R-DME-179812); (R-DME-180292); (R-DME-180336); (R-DME-182971); (R-DME-1963642); (R-DME-212718); (R-DME-5673001); (R-DME-6785631); (R-DME-6811558); (R-DME-8856825); (R-DME-8856828); (R-DME-8863795)", "pathway_count": 20, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;19349973;25409104;8244010", "class_list": "", "function": "Has a role in spermatogenesis and oogenesis (PubMed:8244010). Might have a role in triglyceride homeostasis (PubMed:25409104). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0E5", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep;GO:0070328 triglyceride homeostasis;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q95RU0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95ST2-1", "uniprot_id": "WLS_DROME", "mass": 67890.0, "length": 594, "protein_name": "Protein wntless", "gene_name": "wls", "organism": "Fruit fly", "refseq_name": "wntless, isoform A", "refseq_ac": "NP_648445", "gene_names_uniprotkb": "wls; CG6210; evi; srt", "gene_names_refseq": "CG6210; Dmel\\CG6210; Evi/Wls; Evi; Spr; Srt; Wls/Evi; Wls; evi; srt; wls/evi; wls", "protein_names_uniprotkb": "Protein wntless; Evenness interrupted; Sprinter", "protein_names_refseq": "CG6210-PA; evenness interrupted; sprinter; wls-PA; wntless, isoform A; wntless", "tax_id": 7227, "disease": "Zaki syndrome (Disease Ontology:DOID:0070473)", "pathway": " (dme:Dmel_CG6210); (R-DME-3238698)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10731132;12537569;12537572;16678095;16678096;17108000;18160348;18193032;18193037;19837038", "class_list": "", "function": "A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9VTG4", "ec_number_list": "", "go_molecular_function": "GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0050714 positive regulation of protein secretion;GO:0016055 Wnt signaling pathway;GO:0043001 Golgi to plasma membrane protein transport;GO:0033157 regulation of intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q95ST2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95SX8-1", "uniprot_id": "NAA60_DROME", "mass": 31869.0, "length": 276, "protein_name": "N-alpha-acetyltransferase 60", "gene_name": "Naa60", "organism": "Fruit fly", "refseq_name": "N(alpha)-acetyltransferase 60, isoform C", "refseq_ac": "NP_001137929", "gene_names_uniprotkb": "Naa60; CG18177", "gene_names_refseq": "CG18177; DmAAF50213; Dmel\\CG18177; Hat4; NAA60; Naa60; NatF; dNAA60; dNaa60; dNatF", "protein_names_uniprotkb": "N-alpha-acetyltransferase 60; 2.3.1.259; 2.3.1.48; NatF catalytic subunit; dNaa60", "protein_names_refseq": "CG18177-PC; N(alpha)-acetyltransferase 60, isoform C; Naa60-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18177)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;21750686;21981917", "class_list": "", "function": "Displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase., [UniProtKB, PubMed]; Does not show histone acetyltransferase activity toward free histones., [UniProtKB, PubMed]; Shows histone acetyltransferase activity toward free histones., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0F9;Q8IH11;Q9VT42", "ec_number_list": "2.3.1.48;2.3.1.259;2.3.1.311", "go_molecular_function": "GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007059 chromosome segregation;GO:0017196 N-terminal peptidyl-methionine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q95SX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95T10-1", "uniprot_id": "XYLK_DROME", "mass": 49248.0, "length": 421, "protein_name": "Glycosaminoglycan xylosylkinase homolog", "gene_name": "CG3631", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": "NP_650398", "gene_names_uniprotkb": "CG3631", "gene_names_refseq": "CG3631; Dmel\\CG3631", "protein_names_uniprotkb": "Glycosaminoglycan xylosylkinase homolog; 2.7.1.-; Xylose kinase homolog", "protein_names_refseq": "CG3631-PE; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3631); (R-DME-1971475)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;22900076", "class_list": "", "function": "Kylose kinase that mediates the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q95T10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95T19-1", "uniprot_id": "SLIMP_DROME", "mass": 52916.0, "length": 464, "protein_name": "Serine--tRNA synthetase-like protein Slimp", "gene_name": "Slimp", "organism": "Fruit fly", "refseq_name": "Seryl-tRNA synthetase-like insect mitochondrial protein", "refseq_ac": "NP_732958", "gene_names_uniprotkb": "Slimp; CG31133", "gene_names_refseq": "BcDNA:LD24627; CG31133; Dmel\\CG31133; SLIMP; Slimp", "protein_names_uniprotkb": "Serine--tRNA synthetase-like protein Slimp; Seryl-tRNA synthetase-like insect mitochondrial protein", "protein_names_refseq": "CG31133-PA; Seryl-tRNA synthetase-like insect mitochondrial protein; Slimp-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31133)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;20870726", "class_list": "", "function": "Essential protein which may play a role in mitochondrial morphogenesis and function. Has transfer RNA (tRNA)-binding activity and can bind tRNA(Ser) but does not have serine--tRNA ligase activity and does not bind ATP., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0000049 tRNA binding;GO:0004828 serine-tRNA ligase activity;GO:0140733 tRNA ligase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0140715 serine-tRNA ligase complex", "go_biological_process": "GO:0070158 mitochondrial seryl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q95T19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V6G5-1", "uniprot_id": "TAZ_DROME", "mass": 43016.0, "length": 378, "protein_name": "Tafazzin", "gene_name": "Taz", "organism": "Fruit fly", "refseq_name": "tafazzin, isoform D", "refseq_ac": "NP_001188916", "gene_names_uniprotkb": "Taz; CG8766; Dmel\\CG8766; Dmel_CG8766; TAZ; dTAZ; dTaz; tafazzin; taz", "gene_names_refseq": "CG8766; Dmel\\CG8766; TAZ; Taz; dTAZ; dTaz; tafazzin; taz", "protein_names_uniprotkb": "Tafazzin; 2.3.1.-; TAZ; dTAZ", "protein_names_refseq": "CG8766-PD; Taz-PD; tafazzin, isoform D; tafazzins; tafazzin", "tax_id": 7227, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); visceral heterotaxy (Disease Ontology:DOID:0050545); cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dme:Dmel_CG8766); (R-DME-1268020); (R-DME-1482798)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10731132;11102369;12537568;12537569;12537572;12537573;12537574;16110336;16855048;17082194;17569856;17569867;19114128;19164547;19416660;19700766;22941046;25589440;25598000;26109356;26109357;29405656;31110016", "class_list": "", "function": "Acyltransferase required to remodel newly synthesized phospholipid cardiolipin (1',3'-bis-[1,2-diacyl-sn-glycero-3-phospho]-glycerol or CL), a key component of the mitochondrial inner membrane, with tissue specific acyl chains necessary for adequate mitochondrial function. Its role in cellular physiology is to improve mitochondrial performance (By similarity). CL is critical for the coassembly of lipids and proteins in mitochondrial membranes (PubMed:16855048, PubMed:17082194, PubMed:19114128, PubMed:19416660, PubMed:19700766). For instance, remodeling of the acyl groups of CL in the mitochondrial inner membrane affects the assembly and stability of respiratory chain complex IV and its supercomplex forms (By similarity). Catalyzes the transacylation between phospholipids and lysophospholipids, with the highest rate being between phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) and CL (PubMed:17082194, PubMed:19416660, PubMed:22941046). Catalyzes both 1-acyl-sn-glycero-3-phosphocholine (lysophosphatidylcholine or LPC) reacylation and PC-CL transacylation, that means, it exchanges acyl groups between CL and PC by a combination of forward and reverse transacylations. Also catalyzes transacylations between other phospholipids such as phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) and CL, between PC and PE, and between PC and phosphatidate (1,2-diacyl-sn-glycero-3-phosphate or PA), although at lower rate (PubMed:17082194). Not regiospecific, it transfers acyl groups into any of the sn-1 and sn-2 positions of the monolysocardiolipin (MLCL), which is an important prerequisite for uniformity and symmetry in CL acyl distribution. Cannot transacylate dilysocardiolipin (DLCL), thus, the role of MLCL is limited to that of an acyl acceptor (PubMed:19416660). CoA-independent, it can reshuffle molecular species within a single phospholipid class (PubMed:17082194, PubMed:22941046). Redistributes fatty acids between MLCL, CL, and other lipids, which prolongs the half-life of CL (PubMed:31110016). Its action is completely reversible, which allows for cyclic changes, such as fission and fusion or bending and flattening of the membrane. Hence, by contributing to the flexibility of the lipid composition, it plays an important role in the dynamics of mitochondria membranes (PubMed:22941046). Essential for the final stage of spermatogenesis, spermatid individualization (PubMed:19164547). Required for the initiation of mitophagy (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8ML32;Q8SZ79;Q9U9U8;Q9V6G4", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0016746 acyltransferase activity;GO:0008374 O-acyltransferase activity;GO:0032577 phosphatidylcholine:cardiolipin O-linoleoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0035965 cardiolipin acyl-chain remodeling;GO:0006644 phospholipid metabolic process;GO:0007291 sperm individualization;GO:0032048 cardiolipin metabolic process;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9V6G5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V5N8-1", "uniprot_id": "STAN_DROME", "mass": 397143.0, "length": 3579, "protein_name": "Protocadherin-like wing polarity protein stan", "gene_name": "stan", "organism": "Fruit fly", "refseq_name": "starry night, isoform C", "refseq_ac": "NP_001188903", "gene_names_uniprotkb": "stan; 2R3; CG11895; CT20776; Dmel\\CG11895; Dmel_CG11895; FMI; Flamingo; Flam; Fmi; SN2-7; STAN; Stan; fmi; stan", "gene_names_refseq": "2R3; CG11895; CT20776; Dmel\\CG11895; FMI; Flamingo; Flam; Fmi; SN2-7; STAN; Stan; fmi/stan; fmi; stan", "protein_names_uniprotkb": "Protocadherin-like wing polarity protein stan; Protein flamingo; Protein starry night", "protein_names_refseq": "CG11895-PC; flamingo; serpentine cadherin; stan-PC; starry night, isoform C; starry night; suppressor of NA9 2-7", "tax_id": 7227, "disease": "yellow nail syndrome (Disease Ontology:DOID:0050468); hereditary lymphedema (Disease Ontology:DOID:0050580); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (dme:Dmel_CG11895); (R-DME-350368); (R-DME-350376); (R-DME-350379); (R-DME-350411); (R-DME-350480); (R-DME-450728)", "pathway_count": 7, "publication_count": 42, "publication_id_list": "10469646;10490098;10556066;10570971;10731132;11301004;11874917;11893338;12015972;12506006;12537568;12537572;12537573;12537574;12540853;12642492;12756182;12941693;14636582;15240556;15269282;15556868;15937478;16110336;16469972;16687445;17569856;17569867;18327897;18555784;18701542;18723886;18804371;18849982;19576201;23292348;25589440;26109356;26109357;40245499;9694801;9716412", "class_list": "", "function": "Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields. During planar cell polarity, stabilizes asymmetric PCP domains together with ATP6AP2 (PubMed:23292348)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 22, "predicted_n_glycosites": 20, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q9V5N8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCR6-1", "uniprot_id": "SAV_DROME", "mass": 68146.0, "length": 608, "protein_name": "Scaffold protein salvador", "gene_name": "sav", "organism": "Fruit fly", "refseq_name": "salvador, isoform A", "refseq_ac": "NP_788721", "gene_names_uniprotkb": "sav; CG13831; CG13832; CG33193; Dmel\\CG33193; Dmel_CG33193; SAV1; SAV; SHRP; Salvador; Sav1; Sav; Shar-pei; anon-WO0172774.152; shar-pei", "gene_names_refseq": "CG13831; CG13832; CG33193; Dmel\\CG33193; SAV1; SAV; Salvador/Shar-pei; Salvador; Sav1; Sav; anon-WO0172774.152; sav; shar-pei", "protein_names_uniprotkb": "Scaffold protein salvador; Shar-pei", "protein_names_refseq": "CG33193-PA; salvador, isoform A; salvador/shar-pei; salvador; sav-PA", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); colonic disease (Disease Ontology:DOID:5353); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG33193); (R-DME-2028269); (R-DME-390089); (R-DME-390098); (R-DME-390150)", "pathway_count": 5, "publication_count": 33, "publication_id_list": "10731132;12202036;12223493;12421711;12537568;12537569;12537572;12537573;12537574;12941273;12941274;14502294;14502295;14561774;15766530;16096061;16110336;17174922;17347649;17569856;17569867;17889654;18256197;18327897;19330023;19710173;19733165;20159598;20303269;23263283;25589440;26109356;26109357", "class_list": "", "function": "Plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Required for cell cycle exit in eye imaginal disk and hid-induced apoptotic cell deaths that are part of normal retinal development. Activation of Drice in eye imaginal disk by either Hid or Rpr is almost completely blocked by Sav expression., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQH6;Q8T9A6;Q9VCR5", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045177 apical part of cell;GO:0106037 apicomedial cortex", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0048814 regulation of dendrite morphogenesis;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9VCR6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGU5-1", "uniprot_id": "TTC14_DROME", "mass": 99870.0, "length": 872, "protein_name": "Tetratricopeptide repeat protein 14 homolog", "gene_name": "Dmel\\CG6621", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": "NP_650036", "gene_names_uniprotkb": "Dmel\\CG6621; CG6621; Dmel_CG6621; TTC14", "gene_names_refseq": "CG6621; Dmel\\CG6621; TTC14", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 14 homolog; TPR repeat protein 14 homolog", "protein_names_refseq": "CG6621-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6621)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZH3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VGU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VEZ3-1", "uniprot_id": "MSPS_DROME", "mass": 225980.0, "length": 2042, "protein_name": "Protein mini spindles", "gene_name": "msps", "organism": "Fruit fly", "refseq_name": "mini spindles, isoform C", "refseq_ac": "NP_732105", "gene_names_uniprotkb": "msps; CG5000; Dis1; Dmel\\CG5000; Dmel_CG5000; MSPS; Msps; TOG; XMAP215; anon-WO0140519.136", "gene_names_refseq": "CG5000; Dis1; Dmel\\CG5000; MSPS; Msps; TOG; XMAP215; anon-WO0140519.136; msps", "protein_names_uniprotkb": "Protein mini spindles", "protein_names_refseq": "CG5000-PC; mini spindles, isoform C; mini spindles; mini-spindles; minispindles; msps-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5000)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10477755;10731132;11433295;12537568;12537569;12537572;12537573;12537574;15530399;15775959;16110336;16303556;17569856;17569867;17889670;19836241;21965297;24966168;25589440;25720490;26109356;26109357;26953351;32066907;33725482;37041188", "class_list": "", "function": "Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization (Probable) (PubMed:10477755, PubMed:11433295, PubMed:15530399, PubMed:15775959, PubMed:16303556, PubMed:26953351, PubMed:32066907). Function in neurons is essential for adult survival, and is important for climbing behavior and activity (PubMed:37041188). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:16303556, PubMed:17889670). May act as a microtubule antipause factor that rapidly catalyzes the transition from pause to either growth or shrinkage (PubMed:15775959). Involved in mitotic spindle elongation (PubMed:16303556). Involved in the establishment of cell polarity and mitotic spindle orientation in neuroblasts (PubMed:26953351). Required for maintaining the bipolarity of acentrosomal meiotic spindles; the function is dependent on tacc and involves ncd (PubMed:11433295). Involved in oocyte microtubule cytoskeleton organization and bicoid mRNA localization (PubMed:15530399). Seems to be involved in elongation of kinetochore-derived microtubule fibers (PubMed:19836241). In fat body cells, essential component of perinuclear non-centrosomal microtubule-organizing centers (ncMTOCs) which function to accommodate the organization of microtubule (MT) networks to control nuclear positioning and dynein motor-based retrograde endosomal trafficking (PubMed:32066907). Within the ncMTOCs, Msp300 and shot anchors the ncMTOC at the nuclear surface and recruits the MT minus-end regulators Patronin and Nin for assembly, anchoring and/or stabilization of circumferential and radial MTs at the ncMTOCs (PubMed:32066907). Patronin, and perhaps Nin, then recruits msps to the ncMTOC where it is required for the gamma-tubulin-independent elongation and assembly of radial MTs (PubMed:32066907)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQC0", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0051010 microtubule plus-end binding;GO:0015631 tubulin binding;GO:0061863 microtubule plus end polymerase", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005819 spindle;GO:0048471 perinuclear region of cytoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0000278 mitotic cell cycle;GO:0007143 female meiotic nuclear division;GO:0000132 establishment of mitotic spindle orientation;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q9VEZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VN45-1", "uniprot_id": "SPART_DROME", "mass": 59784.0, "length": 553, "protein_name": "Protein spartin", "gene_name": "spartin", "organism": "Fruit fly", "refseq_name": "spartin, isoform B", "refseq_ac": "NP_001246910", "gene_names_uniprotkb": "spartin; CG12001; Dmel\\CG12001; Dmel_CG12001; Spartin; dSp", "gene_names_refseq": "CG12001; Dmel\\CG12001; Spartin; dSp; spartin", "protein_names_uniprotkb": "Protein spartin", "protein_names_refseq": "CG12001-PB; spartin, isoform B; spartin-PB", "tax_id": 7227, "disease": "Troyer syndrome (Disease Ontology:DOID:0050886)", "pathway": " (dme:Dmel_CG12001)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17018572;17569856;17569867;23439121;25589440;26109356;26109357", "class_list": "", "function": "During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86MQ7", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0043195 terminal bouton", "go_biological_process": "GO:0007399 nervous system development;GO:0051301 cell division;GO:0030514 negative regulation of BMP signaling pathway;GO:0002092 positive regulation of receptor internalization;GO:0045886 negative regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VN45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VI55-1", "uniprot_id": "UFL1_DROME", "mass": 87483.0, "length": 782, "protein_name": "E3 UFM1-protein ligase 1 homolog", "gene_name": "Ufl1", "organism": "Fruit fly", "refseq_name": "UFM1 specific ligase 1, isoform C", "refseq_ac": "NP_001246957", "gene_names_uniprotkb": "Ufl1; CG1104; Dmel\\CG1104; Dmel_CG1104; UFL1", "gene_names_refseq": "CG1104; Dmel\\CG1104; UFL1; Ufl1", "protein_names_uniprotkb": "E3 UFM1-protein ligase 1 homolog; 2.3.2.-; E3 UFM1-protein transferase 1 homolog; UFM1 specific ligase 1", "protein_names_refseq": "CG1104-PC; UFM1 specific ligase 1, isoform C; Ufl1-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1104); (R-DME-983168)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26872069;37086384", "class_list": "", "function": "E3 UFM1-protein ligase that mediates ufmylation of target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8INS2", "ec_number_list": "2.3.2.27;2.3.2.25;2.3.2.23;2.3.2.31;2.3.2.26;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0061666 UFM1 ligase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VI55-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GPJ1-1", "uniprot_id": "SKEL2_DROME", "mass": 165043.0, "length": 1503, "protein_name": "Protein Skeletor, isoforms D/E", "gene_name": "Skel", "organism": "Fruit fly", "refseq_name": "skeletor, isoform D", "refseq_ac": "NP_001027173", "gene_names_uniprotkb": "Skel; 2Ab3; CG14681; CG14682; CG31261; CG32922; CG33676; CG43161; Dmel\\CG43161; Dmel_CG43161; skeletor", "gene_names_refseq": "2Ab3; CG14681; CG14682; CG31261; CG32922; CG33676; CG43161; Dmel\\CG43161; Skel; skeletor", "protein_names_uniprotkb": "Protein Skeletor, isoforms D/E", "protein_names_refseq": "CG43161-PD; Skel-PD; skeletor, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43161)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11134070;12537568;12537569;12537572;12537573;12537574;15356261;15367580;15389869;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Provides structural support to stabilize and organize the microtubule spindle during mitosis (within embryonic somatic cells) and meiosis (within spermatocytes). The role in mitosis regulation depends on the Ran pathway., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0R5", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005819 spindle;GO:0005874 microtubule;GO:0005700 polytene chromosome", "go_biological_process": "GO:0051301 cell division;GO:0051225 spindle assembly;GO:0051321 meiotic cell cycle;GO:0006997 nucleus organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9GPJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGP2-1", "uniprot_id": "NINAG_DROME", "mass": 63475.0, "length": 581, "protein_name": "Neither inactivation nor afterpotential protein G", "gene_name": "ninaG", "organism": "Fruit fly", "refseq_name": "ninaG, isoform B", "refseq_ac": "NP_001247047", "gene_names_uniprotkb": "ninaG; CG6728; Dmel\\CG6728; Dmel_CG6728; NinaG", "gene_names_refseq": "CG6728; Dmel\\CG6728; NinaG; ninaG", "protein_names_uniprotkb": "Neither inactivation nor afterpotential protein G; 1.-.-.-", "protein_names_refseq": "CG6728-PB; ninaG, isoform B; ninaG-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6728)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15640158;16110336;16464863;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Oxidoreductase involved in biosynthesis of 3-hydroxyretinal, a chromophore for rhodopsin Rh1. Not responsible for the initial hydroxylation of the retinal ring but rather acts in a subsequent step in chromophore production. May catalyze the conversion of (3R)-3-hydroxyretinol to the 3S enantiomer., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSH3", "ec_number_list": "", "go_molecular_function": "GO:0016614 oxidoreductase activity, acting on CH-OH group of donors;GO:0050660 flavin adenine dinucleotide binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0046154 rhodopsin metabolic process;GO:0001523 retinoid metabolic process;GO:0007601 visual perception;GO:0061541 rhabdomere morphogenesis;GO:1990146 protein localization to rhabdomere", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VGP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V576-1", "uniprot_id": "WUN_DROME", "mass": 42789.0, "length": 379, "protein_name": "Putative phosphatidate phosphatase", "gene_name": "wun", "organism": "Fruit fly", "refseq_name": "wunen, isoform A", "refseq_ac": "NP_477193", "gene_names_uniprotkb": "wun; CG8804; Dmel\\CG8804; Dmel_CG8804; LPP-like; Wunen; Wun; l(2)k16806", "gene_names_refseq": "CG8804; Dmel\\CG8804; LPP-like; Wunen; Wun; l(2)k16806; wun", "protein_names_uniprotkb": "Putative phosphatidate phosphatase; 3.1.3.4; Germ cell guidance factor; Phosphatidic acid phosphatase type 2; Protein wunen", "protein_names_refseq": "CG8804-PA; Wunen1; wun-PA; wunen 1; wunen, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8804); (R-DME-419408); (R-DME-9845614)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10731132;10731138;12537568;12537569;12537572;12537573;12537574;12856002;14725715;16110336;17569856;17569867;25589440;26109356;26109357;8985246", "class_list": "", "function": "Responsible for guiding the germ cells early in the process of migration from the lumen of the developing gut towards the overlying mesoderm, where the germ cells enter the gonads. May be involved in lipid metabolism., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P91661;Q8MKU5;Q8WT60;Q9U9Y7", "ec_number_list": "3.1.3.-;3.1.3.4", "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0016328 lateral plasma membrane;GO:0005918 septate junction;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050829 defense response to Gram-negative bacterium;GO:0006644 phospholipid metabolic process;GO:0035234 ectopic germ cell programmed cell death;GO:0008354 germ cell migration", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9V576-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W5N2-1", "uniprot_id": "RL38_DROME", "mass": 8200.0, "length": 70, "protein_name": "Large ribosomal subunit protein eL38", "gene_name": "RpL38", "organism": "Fruit fly", "refseq_name": "ribosomal protein L38, isoform A", "refseq_ac": "NP_001036440", "gene_names_uniprotkb": "RpL38; 41Af; 41Ag; BcDNA:RE42506; CG18001; CG40278; Dmel\\CG18001; Dmel_CG18001; E-2b; GroupIV; L38e; M(2)41A; M(2)S2; M(2)S3; Rp L38; Rpl38; l(2)41Af; l(2)41Ag; l(2)41Ai; l(2)EMS4-72; l(2)EMS45-72; l(2R)A'", "gene_names_refseq": "41Af; 41Ag; BcDNA:RE42506; CG18001; CG40278; Dmel\\CG18001; E-2b; GroupIV; L38e; M(2)41A; M(2)S2; M(2)S3; Rp L38; RpL38; Rpl38; l(2)41Af; l(2)41Ag; l(2)41Ai; l(2)EMS4-72; l(2)EMS45-72; l(2R)A'", "protein_names_uniprotkb": "Large ribosomal subunit protein eL38; 60S ribosomal protein L38", "protein_names_refseq": "CG18001-PA; Minute(2)41A; RpL38-PA; enhancer on chromosome 2, complementation group b; lethal(2)41Af; nipped; ribosomal protein 38; ribosomal protein L38, isoform A", "tax_id": 7227, "disease": "otitis media (Disease Ontology:DOID:10754)", "pathway": " (dme:Dmel_CG18001); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0022618 protein-RNA complex assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W5N2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V9K7-1", "uniprot_id": "SRRT_DROME", "mass": 107222.0, "length": 943, "protein_name": "Serrate RNA effector molecule homolog", "gene_name": "Ars2", "organism": "Fruit fly", "refseq_name": "arsenic resistance protein 2, isoform A", "refseq_ac": "NP_610203", "gene_names_uniprotkb": "Ars2; CG7843; Dmel\\CG7843; Dmel_CG7843; anon-WO0118547.166; ars2", "gene_names_refseq": "Ars2; CG7843; Dmel\\CG7843; anon-WO0118547.166; ars2", "protein_names_uniprotkb": "Serrate RNA effector molecule homolog; Arsenite-resistance protein 2 homolog", "protein_names_refseq": "Ars2-PA; CG7843-PA; arsenic resistance protein 2, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7843); (R-DME-6807505); (R-DME-72163); (R-DME-9770562); (R-DME-9930044)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;19632183;25589440;26109356;26109357", "class_list": "", "function": "Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZ50;Q53XG1;Q8SWW6;Q95TJ0", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0016604 nuclear body;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0005634 nucleus", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0045071 negative regulation of viral genome replication;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0030422 siRNA processing;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9V9K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V579-1", "uniprot_id": "PREL_DROME", "mass": 26273.0, "length": 236, "protein_name": "Protein preli-like", "gene_name": "prel", "organism": "Fruit fly", "refseq_name": "preli-like, isoform C", "refseq_ac": "NP_001260824", "gene_names_uniprotkb": "prel; BcDNA:LD36516; CG8806; Dmel\\CG8806; Dmel_CG8806", "gene_names_refseq": "BcDNA:LD36516; CG8806; Dmel\\CG8806; prel", "protein_names_uniprotkb": "Protein preli-like", "protein_names_refseq": "CG8806-PC; Preli-like; prel-PC; preli-like, isoform C; preli; protein of relevant evolutionary and lymphoid interest-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8806); (R-DME-6803204)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15700158;16110336;17569856;17569867;19855018;25589440;26109356;26109357", "class_list": "", "function": "Involved in maintaining the structural and functional integrity of mitochondria (PubMed:19855018). Activity is required for maintaining the subcellular distribution, shape and activity of mitochondria in neurons and as a consequence has an important role in the development and maintenance of dendritic arbors (PubMed:19855018). Function may be particularly important in class IV dendritic arborization (da) neurons (PubMed:19855018)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RE6", "ec_number_list": "", "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0015914 phospholipid transport;GO:0048813 dendrite morphogenesis;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9V579-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V5Z7-1", "uniprot_id": "AQP_DROME", "mass": 25575.0, "length": 245, "protein_name": "Aquaporin", "gene_name": "Drip", "organism": "Fruit fly", "refseq_name": "drip, isoform B", "refseq_ac": "NP_523697", "gene_names_uniprotkb": "Drip; CG9023; DRIP; Dmel\\CG9023; Dmel_CG9023; I; anon-48Aa; drip", "gene_names_refseq": "CG9023; DRIP; Dmel\\CG9023; Drip; I; anon-48Aa; drip", "protein_names_uniprotkb": "Aquaporin", "protein_names_refseq": "CG9023-PB; Drip-PB; aquaporin; drip, isoform B; drosophila integral protein; transcript group I", "tax_id": 7227, "disease": "Alpers-Huttenlocher syndrome (Disease Ontology:DOID:0080122); megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); transverse myelitis (Disease Ontology:DOID:0080743); nephrogenic diabetes insipidus type 2 (Disease Ontology:DOID:0081061); cataract 15 multiple types (Disease Ontology:DOID:0110251); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Bothnian type palmoplantar keratoderma (Disease Ontology:DOID:0111707); dry eye syndrome (Disease Ontology:DOID:10140); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); uveitis (Disease Ontology:DOID:13141); blindness (Disease Ontology:DOID:1432); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); diabetic ketoacidosis (Disease Ontology:DOID:1837); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); thymoma (Disease Ontology:DOID:3275); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); retinal disease (Disease Ontology:DOID:5679); central pontine myelinolysis (Disease Ontology:DOID:636); cataract (Disease Ontology:DOID:83); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); diabetes mellitus (Disease Ontology:DOID:9351); diabetes insipidus (Disease Ontology:DOID:9409); intracranial hypertension (Disease Ontology:DOID:9428); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (dme:Dmel_CG9023); (R-DME-1237044); (R-DME-1247673); (R-DME-432040); (R-DME-432047)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Forms a water-specific channel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24148;Q3KN56;Q8MKY6", "ec_number_list": "", "go_molecular_function": "GO:0015250 water channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0003091 renal water homeostasis;GO:0055085 transmembrane transport;GO:0006833 water transport;GO:0050891 multicellular organismal-level water homeostasis;GO:0048878 chemical homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9V5Z7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W1X9-1", "uniprot_id": "OCAD1_DROME", "mass": 28621.0, "length": 257, "protein_name": "OCIA domain-containing protein 1", "gene_name": "asrij", "organism": "Fruit fly", "refseq_name": "asrij, isoform A", "refseq_ac": "NP_611733", "gene_names_uniprotkb": "asrij; Asrij; CG13533; Dmasrij; Dmel\\CG13533; Dmel_CG13533; FBgn 34793; arj", "gene_names_refseq": "Asrij; CG13533; Dmasrij; Dmel\\CG13533; FBgn 34793; arj; asrij", "protein_names_uniprotkb": "OCIA domain-containing protein 1; OCAD1", "protein_names_refseq": "CG13533-PA; asrij, isoform A; asrij-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13533)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22110713;24707047;25589440;26109356;26109357", "class_list": "", "function": "Maintains stem cell potency (PubMed:24707047). Involved in endocytic pathways that mediate signaling during hematopoiesis (PubMed:22110713, PubMed:24707047)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0006897 endocytosis;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0010821 regulation of mitochondrion organization;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9W1X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V727-1", "uniprot_id": "ASX_DROME", "mass": 179842.0, "length": 1669, "protein_name": "Polycomb group protein Asx", "gene_name": "Asx", "organism": "Fruit fly", "refseq_name": "additional sex combs, isoform A", "refseq_ac": "NP_725398", "gene_names_uniprotkb": "Asx; ASX; CG8787; Dmel\\CG8787; Dmel_CG8787; FBgn0261823; xen", "gene_names_refseq": "ASX; Asx; CG8787; Dmel\\CG8787; FBgn0261823; xen", "protein_names_uniprotkb": "Polycomb group protein Asx; Protein additional sex combs", "protein_names_refseq": "Asx-PA; CG8787-PA; additional Sex combs; additional sex combs, isoform A; additional sex comb; additionnal sex comb; xenicid", "tax_id": 7227, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); Bainbridge-Ropers syndrome (Disease Ontology:DOID:0080893); myeloproliferative neoplasm (Disease Ontology:DOID:2226); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG8787); (R-DME-5689603)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10731132;11397012;12537568;12537572;12537573;12537574;16110336;17569856;17569867;20436459;25589440;25995770;26109356;26109357;30258054;30639226;36180891;9477319", "class_list": "", "function": "Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK118ub1) (PubMed:20436459, PubMed:30258054, PubMed:30639226, PubMed:36180891). Activator of the PR-DUB complex involved in ubiquitin binding and allosteric activation of calypso deubiquitinase activity (PubMed:30639226). PR-DUB does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459). PR-DUB is required to maintain the transcriptionally repressive state of homeotic genes throughout development (PubMed:20436459). The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20436459). Atypical Polycomb group protein, which may be involved in both Polycomb group (PcG) and trithorax group (trxG) complexes (PubMed:9477319). PcG and trxG proteins act by forming multiprotein complexes, which are respectively required to maintain the transcriptionally repressive and transcriptionally active state of homeotic genes throughout development (Probable). PcG and trxG protein complexes are not required to initiate repression and activation, but to maintain it during later stages of development (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O76930", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035517 PR-DUB complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9V727-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGR7-1", "uniprot_id": "Y6693_DROME", "mass": 34890.0, "length": 299, "protein_name": "J domain-containing protein CG6693", "gene_name": "Dmel\\CG6693", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001262473", "gene_names_uniprotkb": "Dmel\\CG6693; CG6693; Dmel_CG6693", "gene_names_refseq": "CG6693; Dmel\\CG6693", "protein_names_uniprotkb": "J domain-containing protein CG6693", "protein_names_refseq": "CG6693-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6693)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VGR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VI93-1", "uniprot_id": "RN_DROME", "mass": 100948.0, "length": 946, "protein_name": "Zinc finger protein rotund", "gene_name": "rn", "organism": "Fruit fly", "refseq_name": "rotund, isoform E", "refseq_ac": "NP_649715", "gene_names_uniprotkb": "rn; 5.3; CG10040; CG14600; CG14601; CG14603; CG32466; CG32467; CG42277; Dipr; Dmel\\CG42277; Dmel_CG42277; P5.3; Rn; roe; tod; tot", "gene_names_refseq": "5.3; CG10040; CG14600; CG14601; CG14603; CG32466; CG32467; CG42277; Dipr; Dmel\\CG42277; P5.3; Rn; rn; roe; tod; tot", "protein_names_uniprotkb": "Zinc finger protein rotund; Zinc finger protein roughened eye", "protein_names_refseq": "CG42277-PE; Distal-into-proximal; T-one deficient; rn-PE; rotund, isoform E; rotund; roughened eye; t-one transformed", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42277)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11874922;12163403;12537568;12537572;12537573;12537574;16110336;17428824;17569856;17569867;18430928;18571155;25589440;26109356;26109357", "class_list": "", "function": "Transcription factor involved in imaginal disks development. Isoform rn is required in the wings, antenna, haltere, proboscis and legs disks, while isoform roe is required in the eye disk. Together with nab corepressor, it is involved in the initiation and maintenance of wingless (wg) expression in the wing hinge, by limiting the expression of wg to this compartment. Also required for the epithelial-mesenchymal transition branch of basolateral junctions signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4V6Z5;Q8WRV3;Q9VI90", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001708 cell fate specification;GO:0048749 compound eye development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VI93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGH7-1", "uniprot_id": "CLCN2_DROME", "mass": 133648.0, "length": 1193, "protein_name": "Chloride channel protein 2", "gene_name": "ClC-a", "organism": "Fruit fly", "refseq_name": "chloride channel-a, isoform G", "refseq_ac": "NP_001097751", "gene_names_uniprotkb": "ClC-a; CG14726; CG31116; CG6942; CLC-2; Clc-a; DmClC-2; DmClC-a; DmClCa; Dmel\\CG31116; Dmel_CG31116; FBgn0037951", "gene_names_refseq": "CG14726; CG31116; CG6942; CLC-2; ClC-a; Clc-a; DmClC-2; DmClC-a; DmClCa; Dmel\\CG31116; FBgn0037951", "protein_names_uniprotkb": "Chloride channel protein 2; Chloride channel-a; ClC-2; DmClC-2", "protein_names_refseq": "CG31116-PG; ClC-a-PG; chloride channel-a, isoform G", "tax_id": 7227, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); Becker disease (Disease Ontology:DOID:0081335); Thomsen disease (Disease Ontology:DOID:0081336); Bartter disease type 3 (Disease Ontology:DOID:0110144); Bartter disease type 4b (Disease Ontology:DOID:0110146); sensorineural hearing loss (Disease Ontology:DOID:10003); leukodystrophy (Disease Ontology:DOID:10579); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); cystic fibrosis (Disease Ontology:DOID:1485); myotonia congenita (Disease Ontology:DOID:2106); myopathy (Disease Ontology:DOID:423); Bartter disease (Disease Ontology:DOID:445); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (dme:Dmel_CG31116); (R-DME-2672351)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15501232;16110336;17018572;17569856;17569867;17601953;25589440;26109356;26109357", "class_list": "", "function": "Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4VCL3;A8JQX8;A8JQX9;E1JIJ0;Q7YU63;Q8INJ7;Q8MRL4;Q9VGH8", "ec_number_list": "", "go_molecular_function": "GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0016324 apical plasma membrane;GO:0034707 chloride channel complex;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0003091 renal water homeostasis;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0003097 renal water transport;GO:0035377 transepithelial water transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VGH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VF30-1", "uniprot_id": "MCMR_DROME", "mass": 97585.0, "length": 885, "protein_name": "DNA replication licensing factor REC", "gene_name": "rec", "organism": "Fruit fly", "refseq_name": "recombination-defective, isoform B", "refseq_ac": "NP_001262615", "gene_names_uniprotkb": "rec; CG14875; CG31293; CG4828; Dmel\\CG31293; Dmel_CG31293; MCM8; Rec; rec-1; rec1", "gene_names_refseq": "CG14875; CG31293; CG4828; Dmel\\CG31293; MCM8; Rec; rec-1; rec1; rec", "protein_names_uniprotkb": "DNA replication licensing factor REC; 5.6.2.4; DNA helicase MCM8; Probable DNA 3'-5' helicase REC/MCM8; Protein mini chromosome maintenance-related; Protein recombination-defective", "protein_names_refseq": "CG31293-PB; mini-chromosome maintenance 8; rec-PB; recombination defective; recombination-defective, isoform B", "tax_id": 7227, "disease": "primary ovarian insufficiency 10 (Disease Ontology:DOID:0080867)", "pathway": " (dme:Dmel_CG31293); (R-DME-176187); (R-DME-68689); (R-DME-68949); (R-DME-68962)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;14676427;16110336;16189551;17569856;17569867;25589440;26109356;26109357;36355348", "class_list": "", "function": "A probable 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase (By similarity). Required for meiotic DNA recombination in females (PubMed:14676427). Facilitates germline and somatic mitochondrial DNA recombination (PubMed:36355348). Facilitates repair synthesis during meiotic recombination (PubMed:16189551). Probably not involved in DNA repair and recombination in somatic cells (PubMed:14676427)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;2.7.11.22;2.7.11.23;2.7.7.7;3.1.11.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;2.7.7.-;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005759 mitochondrial matrix;GO:0042555 MCM complex", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0006270 DNA replication initiation;GO:0007131 reciprocal meiotic recombination;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VF30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VC56-1", "uniprot_id": "PUF_DROME", "mass": 440375.0, "length": 3912, "protein_name": "Ubiquitin carboxyl-terminal hydrolase puf", "gene_name": "puf", "organism": "Fruit fly", "refseq_name": "puffyeye, isoform D", "refseq_ac": "NP_651275", "gene_names_uniprotkb": "puf; BcDNA:AT28817; CG5794; Dmel\\CG5794; Dmel_CG5794; NEST:bs19d10; Puf; Q9VC56; USP34; Usp34", "gene_names_refseq": "BcDNA:AT28817; CG5794; Dmel\\CG5794; NEST:bs19d10; Puf; Q9VC56; USP34; Usp34; puf", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase puf; 3.4.19.12; Protein puffyeye", "protein_names_refseq": "CG5794-PD; puf-PD; puffyeye, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5794); (R-DME-445989); (R-DME-5689880); (R-DME-9758274)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;24173801;25027767;25589440;26109356;26109357;35393473", "class_list": "", "function": "Ubiquitin hydrolase that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:24173801). Essential for Myc-mediated cell growth and proliferation in developing eyes and wings (PubMed:24173801). In the wing and eye, the deubiquitinating activity acts as an antagonist to the SCF E3 ubiquitin-protein ligase member archipelago (ago) to regulate Myc and CycE stability and thus control cell growth and proliferation (PubMed:24173801). Also appears to regulate ago by modulating its induction by Myc (PubMed:24173801). May also promote cell apoptosis in the wing imaginal disk, acting in an apoptotic pathway that appears to be largely independent of Myc (PubMed:24173801). Required for preventing the activation of the immune deficiency (Imd) and Toll signaling cascades under unchallenged conditions (PubMed:25027767). Also appears to be involved in modulating the differential expression of certain antimicrobial peptides (AMP) in response to infection by either Gram-positive or Gram-negative bacteria (PubMed:25027767). Involved in the regulation of DNA damage repair pathways, including euchromatic site-specific double strand break (DSB) repair (PubMed:35393473)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7KS15", "ec_number_list": "2.3.2.23;2.7.11.1;2.7.11.25;3.4.19.12;2.7.11.10", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0030307 positive regulation of cell growth;GO:0043687 post-translational protein modification;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VC56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XZ58-1", "uniprot_id": "CSN5_DROME", "mass": 37083.0, "length": 327, "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "CSN5", "organism": "Fruit fly", "refseq_name": "COP9 signalosome subunit 5, isoform A", "refseq_ac": "NP_477442", "gene_names_uniprotkb": "CSN5; BcDNA.LD14392; BcDNA:LD14392; CG14884; CH5; CSN-5; CSN5; Csn5; DCH5; Dch5; Dmel\\CG14884; Dmel_CG14884; JAB1; Jab1; JadBp; Q9XZ58; csn5; dch5; l(3)89Cf; l(3)L4032; l(3)M203; quo", "gene_names_refseq": "BcDNA.LD14392; BcDNA:LD14392; CG14884; CH5; CSN-5; CSN5; Csn5; DCH5; Dch5; Dmel\\CG14884; JAB1/CSN5; JAB1; Jab1; JadBp; Q9XZ58; csn5; dch5; jab1/csn5; l(3)89Cf; l(3)L4032; l(3)M203; quo", "protein_names_uniprotkb": "COP9 signalosome complex subunit 5; 3.4.-.-; Dch5; JAB1 homolog; Signalosome subunit 5", "protein_names_refseq": "CG14884-PA; COP9 complex homolog subunit 5; COP9 complex subunit 5; COP9 signalosome subunit 5, isoform A; CSN5-PA; JUN activation domain-binding protein-1; Jun activation domain binding protein; drosophila COP9 signalosome homolog 5", "tax_id": 7227, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG14884); (R-DME-5696394); (R-DME-6781823); (R-DME-8856825); (R-DME-8951664)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10531038;10731132;11779478;12032852;12183637;12223399;12397113;12537568;12537572;12537573;12537574;12737805;15735686;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis. Also involved in regulation of axis formation by checkpoint-dependent, translational control of Gurken., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KN57;Q9UB04", "ec_number_list": "2.7.7.6;3.6.4.-;5.6.2.4;2.7.11.22;2.7.11.23;5.6.2.3;3.6.4.12;3.4.-.-", "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0140758 metal-dependent deNEDDylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0034399 nuclear periphery;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0006508 proteolysis;GO:0007409 axonogenesis;GO:0050821 protein stabilization;GO:0045732 positive regulation of protein catabolic process;GO:0045787 positive regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9XZ58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCP1-1", "uniprot_id": "RAD60_DROME", "mass": 47744.0, "length": 424, "protein_name": "DNA repair protein Rad60", "gene_name": "Rad60", "organism": "Fruit fly", "refseq_name": "Rad60, isoform B", "refseq_ac": "NP_001163698", "gene_names_uniprotkb": "Rad60; CG4449; Dmel\\CG4449; Dmel_CG4449; RENi; dRad60; drad60", "gene_names_refseq": "CG4449; Dmel\\CG4449; RENi; Rad60; dRad60; drad60", "protein_names_uniprotkb": "DNA repair protein Rad60", "protein_names_refseq": "CG4449-PB; Rad60, isoform B; Rad60-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4449)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357;26502056", "class_list": "", "function": "Required for repair of DNA double strand breaks which occur during replication or are induced by ionizing radiation (IR) (PubMed:26502056). Functions with dgrn and downstream of the SMC5-SMC6 complex to regulate strand break repair (PubMed:26502056). Likely functions by stabilizing the association of heterochromatic double strand breaks (DSBs) with the nuclear periphery as part of the homologous recombination (HR) repair process (PubMed:26502056)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSB4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0034399 nuclear periphery;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VCP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCE9-1", "uniprot_id": "EPP_DROME", "mass": 84466.0, "length": 751, "protein_name": "Ecdysteroid-phosphate phosphatase", "gene_name": "Epp", "organism": "Fruit fly", "refseq_name": "ecdysteroid phosphate phosphatase, isoform A", "refseq_ac": "NP_651202", "gene_names_uniprotkb": "Epp; CG13604; Dmel\\CG13604; Dmel_CG13604; EPP; UBASH3A", "gene_names_refseq": "CG13604; Dmel\\CG13604; EPP; Epp; UBASH3A", "protein_names_uniprotkb": "Ecdysteroid-phosphate phosphatase; 3.1.3.-; Protein UBASH3A homolog; Ubiquitin-associated and SH3 domain-containing protein", "protein_names_refseq": "CG13604-PA; Epp-PA; ecdysteroid phosphate phosphatase, isoform A; ecdysteroid phosphate phosphatase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13604)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17348005;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Steroid phosphatase that dephosphorylates ecdysteroids such as ecdysone 22-phosphate (E22P), 3-epi-ecdysone 22-phosphate (E22P) and 3-epi-ecdysone 2-phosphate (E2P) (PubMed:17348005). Likely catalyzes the conversion of inactive phosphorylated ecdysteroids into their active forms (By similarity). Shows high activity towards ecdysone 22-phosphate (E22P), but is also significantly active against 3-epi-ecdysone 22-phosphate (E22P) and 3-epi-ecdysone 2-phosphate (E2P) (PubMed:17348005). Also displays acid phosphatase activity towards 4-nitrophenyl phosphate (pNNP) in vitro (PubMed:17348005). Has no activity towards 3-epi-ecdysone 3-phosphate (E3P) (PubMed:17348005)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86PB2", "ec_number_list": "3.1.3.-", "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0016791 phosphatase activity;GO:0102531 ecdysteroid-phosphate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045455 ecdysteroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VCE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V407-1", "uniprot_id": "AXN_DROME", "mass": 81718.0, "length": 745, "protein_name": "Axin", "gene_name": "Axn", "organism": "Fruit fly", "refseq_name": "axin, isoform A", "refseq_ac": "NP_733336", "gene_names_uniprotkb": "Axn; 30; APC; CG7926; D-Axin; DAxin; Daxin; Dmel\\CG7926; Dmel_CG7926; GSK3beta; GS; axin; axn; d-axin; dAXIN; dAxin; din; l(3)S044230", "gene_names_refseq": "0442/30; APC; Axn; CG7926; D-Axin; DAxin; Daxin; Dmel\\CG7926; GSK3beta; GS; axin; axn; d-axin; dAXIN; dAxin; din; l(3)S044230", "protein_names_uniprotkb": "Axin; Axis inhibition protein; d-Axin; dAxin", "protein_names_refseq": "Axn-PA; CG7926-PA; D-axin; Dm axin; axin, isoform A; axin; axn; dAxin; glycogen synthase kinase 3beta", "tax_id": 7227, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); orofacial cleft (Disease Ontology:DOID:0050567); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colon adenoma (Disease Ontology:DOID:0050912); colorectal carcinoma (Disease Ontology:DOID:0080199); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); congenital heart disease (Disease Ontology:DOID:1682); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); craniosynostosis (Disease Ontology:DOID:2340); endometrial adenocarcinoma (Disease Ontology:DOID:2870); gallbladder cancer (Disease Ontology:DOID:3121); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (dme:Dmel_CG7926); (R-DME-195253); (R-DME-196299); (R-DME-209155); (R-DME-209190); (R-DME-209214); (R-DME-209360); (R-DME-209396); (R-DME-209413); (R-DME-209440); (R-DME-209461); (R-DME-432553); (R-DME-4641257); (R-DME-4641262)", "pathway_count": 14, "publication_count": 75, "publication_id_list": "10073940;10102270;10196136;10409506;10421629;10457025;10458606;10477300;10557210;10731132;10838083;10846164;11336703;11430804;11440719;11912487;11927557;11955435;11955436;12000790;12122057;12231619;12432393;12442174;12447397;12537568;12537572;12537573;12537574;12563262;12636921;12663920;12781135;12944510;14636582;14731402;14759367;14966281;15300262;15459103;15563523;15592457;15598741;15616566;15875013;16041759;16110336;16299518;16319317;16326393;16386907;16410523;16630821;17077139;17418796;17569856;17569867;17925225;18327897;18593878;18815259;25589440;26109356;26109357;7481773;8596938;8600384;8898207;8906787;8906794;8938123;8990193;9215627;9482888;9674431", "class_list": "", "function": "Inhibitor of the WG signaling pathway. Down-regulates beta-catenin (armadillo=ARM). Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (zeste-white 3=ZW3)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9XYC1", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030877 beta-catenin destruction complex", "go_biological_process": "GO:1900117 regulation of execution phase of apoptosis;GO:0007507 heart development;GO:0042594 response to starvation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 7.6, "record_id": "Q9V407-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9N2M8-1", "uniprot_id": "HECA_DROME", "mass": 117448.0, "length": 1080, "protein_name": "Headcase protein", "gene_name": "heca", "organism": "Fruit fly", "refseq_name": "headcase, isoform D", "refseq_ac": "NP_001263103", "gene_names_uniprotkb": "heca; CG15532; Dmel\\CG15532; Dmel_CG15532; HDC; Hdc; hac; hdc; l(3)B4-3-20; psg12", "gene_names_refseq": "CG15532; Dmel\\CG15532; HDC; Hdc; hac; hdc; heca; l(3)B4-3-20; psg12", "protein_names_uniprotkb": "Headcase protein", "protein_names_refseq": "CG15532-PD; Fusion-6; headcase, isoform D; headcase; heca-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15532)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8575315;9531534", "class_list": "", "function": "Required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. Involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. Regulated by transcription factor esg. The longer hdc protein is completely functional and the shorter protein carries some function., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24480;Q95SY2;Q9VA84", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0050768 negative regulation of neurogenesis;GO:0033962 P-body assembly;GO:0034063 stress granule assembly;GO:0048102 autophagic cell death", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9N2M8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NDJ2-1", "uniprot_id": "DOM_DROME", "mass": 350239.0, "length": 3198, "protein_name": "Chromatin remodeling protein domino", "gene_name": "dom", "organism": "Fruit fly", "refseq_name": "domino, isoform A", "refseq_ac": "NP_524833", "gene_names_uniprotkb": "dom; 4; 8; CG9696; DOM-A; DOM; Dmel\\CG9696; Dmel_CG9696; DomA; Domino; Dom; anon-WO0172774.190; dDom; dEP400; l(2)k02704; l(2)k08108; p400", "gene_names_refseq": "27/4; CG9696; DOM-A; DOM; Dmel\\CG9696; DomA; Domino; Dom; anon-WO0172774.190; dDom; dEP400; dom; l(2)81/8; l(2)k02704; l(2)k08108; p400", "protein_names_uniprotkb": "Chromatin remodeling protein domino; 3.6.4.-", "protein_names_refseq": "CG9696-PA; Domino-A; dom-PA; domino DNA dependent ATPase; domino, isoform A; domino", "tax_id": 7227, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); developmental disorder of mental health (Disease Ontology:DOID:0060037); Floating-Harbor syndrome (Disease Ontology:DOID:0111358)", "pathway": " (dme:Dmel_CG9696)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10731132;11262242;12537568;12537569;12537572;12537573;12537574;15528408;16024792;16110336;16322456;16508010;17517653;17569856;17569867;18327897;25589440;26109356;26109357;32432549;39708813;40245499", "class_list": "", "function": "Component of a SWR1-like complex that incorporates H2AV genome-wide and specifically at active promoters, in an ATP-dependent manner., [UniProtKB, PubMed]; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12'., [UniProtKB, PubMed]; Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:11262242, PubMed:15528408, PubMed:16508010). Involved in Notch signaling (PubMed:16024792, PubMed:16508010). Involved in oogenesis (PubMed:11262242). Plays a role in the development of the nervous system (PubMed:39708813). Required for repression of E2F target genes (PubMed:17517653). Required for somatic stem cell self-renewal but not for germline stem cell self-renewal (PubMed:16322456)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q7YZ94;Q95TN6;Q968U6;Q9I7V8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex;GO:0000123 histone acetyltransferase complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q9NDJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V968-1", "uniprot_id": "GALL1_DROME", "mass": 23806.0, "length": 218, "protein_name": "MIP18 family protein galla-1", "gene_name": "galla-1", "organism": "Fruit fly", "refseq_name": "galla-1, isoform B", "refseq_ac": "NP_001286642", "gene_names_uniprotkb": "galla-1; CG10404; CG30152; Cg30152; Dmel\\CG30152; Dmel_CG30152; FAM96a; Galla-1; Galla1; galla1", "gene_names_refseq": "CG10404; CG30152; Cg30152; Dmel\\CG30152; FAM96a; Galla-1; Galla1; galla-1; galla1", "protein_names_uniprotkb": "MIP18 family protein galla-1", "protein_names_refseq": "CG30152-PB; galla-1, isoform B; galla-1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30152)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25065591;25589440;26109356;26109357", "class_list": "", "function": "Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005876 spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0051604 protein maturation;GO:0098813 nuclear chromosome segregation;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9V968-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W237-1", "uniprot_id": "RS16_DROME", "mass": 16775.0, "length": 148, "protein_name": "Small ribosomal subunit protein uS9", "gene_name": "RpS16", "organism": "Fruit fly", "refseq_name": "ribosomal protein S16, isoform B", "refseq_ac": "NP_001286731", "gene_names_uniprotkb": "RpS16; CG4046; Dmel\\CG4046; Dmel_CG4046; Rp S16; S16; S9; bs32d05.y1", "gene_names_refseq": "CG4046; Dmel\\CG4046; Rp S16; RpS16; S16; S9; bs32d05.y1", "protein_names_uniprotkb": "Small ribosomal subunit protein uS9; 40S ribosomal protein S16", "protein_names_refseq": "CG4046-PB; RpS16-PB; ribosomal protein S16, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4046); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W237-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W1I2-1", "uniprot_id": "BGCN_DROME", "mass": 139279.0, "length": 1215, "protein_name": "Protein benign gonial cell neoplasm", "gene_name": "bgcn", "organism": "Fruit fly", "refseq_name": "benign gonial cell neoplasm, isoform A", "refseq_ac": "NP_523832", "gene_names_uniprotkb": "bgcn; BGCN; Bgcn; CG10330; CG10331; CG30170; Dmel\\CG30170; Dmel_CG30170; PNBP; b(2)cgn; b(2)gcn; bcgn; ben(2)gcn; cg10331; fs(2)eo-C; fs(2)eo6; fs(2)eoQS2; gcn; pep", "gene_names_refseq": "BGCN; Bgcn; CG10330; CG10331; CG30170; Dmel\\CG30170; PNBP; b(2)cgn; b(2)gcn; bcgn; ben(2)gcn; bgcn; cg10331; fs(2)eo-C; fs(2)eo6; fs(2)eoQS2; gcn; pep", "protein_names_uniprotkb": "Protein benign gonial cell neoplasm", "protein_names_refseq": "CG30170-PA; benign gonial cell neoplasia; benign gonial cell neoplasm, isoform A; benign gonial; benign-(2)-gonial-cell-neoplasm; bgcn-PA; cell neoplasm; gonial-cell-neoplasm; peppercorn; putative nuclear binding protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30170)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10731132;10924476;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;19470484;19556547;23122292;23526974;25412508;25589440;26109356;26109357;28190776;9334284", "class_list": "", "function": "Forms a complex with tut and bam involved in 3'UTR-dependent post-transcriptional repression of several 3'-RNA processing factors, which promotes germline stem cell lineage differentiation and mitosis-to-meiosis transition (PubMed:25412508, PubMed:28190776). Part of a complex with bam involved in 3'-UTR-dependent translational repression of a subset of mRNAs, including those for mei-P26, nanos and shg/E-cadherin; may act as a promiscuous RNA-binding protein tethering bam to its target mRNAs (PubMed:19470484, PubMed:19556547, PubMed:23122292, PubMed:23526974). Required for regulating the progression of gonialblast cells through transit amplification and differentiation into gametes (PubMed:9334284)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W1I3", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003723 RNA binding", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0017148 negative regulation of translation;GO:0048477 oogenesis;GO:0035212 cell competition in a multicellular organism;GO:0030718 germ-line stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9W1I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VHV5-1", "uniprot_id": "ARL8_DROME", "mass": 21254.0, "length": 186, "protein_name": "ADP-ribosylation factor-like protein 8", "gene_name": "Arl8", "organism": "Fruit fly", "refseq_name": "ADP ribosylation factor-like 8, isoform B", "refseq_ac": "NP_001287225", "gene_names_uniprotkb": "Arl8; BcDNA:LD29185; CG7891; Dmel\\CG7891; Dmel_CG7891; Gie; Q9VHV5; arl8", "gene_names_refseq": "Arl8; BcDNA:LD29185; CG7891; Dmel\\CG7891; Gie; Q9VHV5; arl8", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 8; Novel small G protein indispensable for equal chromosome segregation; dGie", "protein_names_refseq": "ADP ribosylation factor-like 8, isoform B; Arl8-PB; CG7891-PB; GTPase indispensable for equal segregation of chromosomes; novel GTPase indispensable for equal segregation of chromosomes", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7891); (R-DME-6798695)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15331635;16110336;16537643;17569856;17569867;25589440;26109356;26109357;29940804;30115618;30174114;33822845", "class_list": "", "function": "Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion (PubMed:16537643, PubMed:29940804, PubMed:30115618). Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes (PubMed:29940804). In larval motor neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30115618, PubMed:30174114). Acts downstream of Rab2 during presynaptic precursor vesicle biogenesis (PubMed:33822845). Essential role in chromosome segregation (PubMed:15331635)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0048487 beta-tubulin binding;GO:0019003 GDP binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043204 perikaryon;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0099054 presynapse assembly;GO:0015031 protein transport;GO:0051301 cell division;GO:0001666 response to hypoxia;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VHV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V877-1", "uniprot_id": "SUB_DROME", "mass": 71387.0, "length": 628, "protein_name": "Kinesin-like protein subito", "gene_name": "sub", "organism": "Fruit fly", "refseq_name": "subito, isoform B", "refseq_ac": "NP_001286548", "gene_names_uniprotkb": "sub; B; CG12298; DmKlp54E; DmSub; Dmel\\CG12298; Dmel_CG12298; Dub; KIF 20A; MKLP2; MKlp2; Mklp2; SUB; Subito; Sub; mei-1794", "gene_names_refseq": "CG12298; DmKlp54E; DmSub; Dmel\\CG12298; Dub; KIF 20A; KIF20A/B; MKLP2; MKlp2; Mklp2; SUB; Subito; Sub; mei-1794; sub", "protein_names_uniprotkb": "Kinesin-like protein subito; Protein double or nothing", "protein_names_refseq": "CG12298-PB; Kinesin_A; double or nothing; double-or-nothing; sub-PB; subito, isoform B; subito", "tax_id": 7227, "disease": "familial restrictive cardiomyopathy 6 (Disease Ontology:DOID:0061025)", "pathway": " (dme:Dmel_CG12298); (R-DME-68884); (R-DME-983189)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;11973304;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Required during female meiosis for bipolar spindle formation in the absence of the centrosomes and chromosome homolog segregation. Also has roles in male meiosis and mitotic divisions of the early embryo., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0140496 gamma-tubulin complex binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0051233 spindle midzone", "go_biological_process": "GO:0016321 female meiosis chromosome segregation;GO:0000278 mitotic cell cycle;GO:0040016 embryonic cleavage;GO:0007018 microtubule-based movement;GO:0007020 microtubule nucleation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9V877-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q960T2-1", "uniprot_id": "SAP47_DROME", "mass": 56980.0, "length": 551, "protein_name": "Synapse-associated protein of 47 kDa", "gene_name": "Sap47", "organism": "Fruit fly", "refseq_name": "Synapse-associated protein 47kD, isoform K", "refseq_ac": "NP_001287350", "gene_names_uniprotkb": "Sap47; CG8884; Dmel\\CG8884; Dmel_CG8884; SAP 47; SAP-47; SAP47; dsap-47; sap47", "gene_names_refseq": "CG8884; Dmel\\CG8884; SAP 47; SAP-47; SAP47; Sap47; dsap-47; sap47", "protein_names_uniprotkb": "Synapse-associated protein of 47 kDa", "protein_names_refseq": "CG8884-PK; Sap47-PK; Synapse-associated protein 47kD, isoform K", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8884)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;7494462", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2Z5;Q24502;Q24503;Q8INC9;Q9VF07", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0045202 synapse", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0008306 associative learning;GO:0007268 chemical synaptic transmission;GO:0038203 TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q960T2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VF08-1", "uniprot_id": "TIM16_DROME", "mass": 15731.0, "length": 141, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim16", "gene_name": "blp", "organism": "Fruit fly", "refseq_name": "black pearl, isoform B", "refseq_ac": "NP_001287349", "gene_names_uniprotkb": "blp; BcDNA:RE11908; Blp; CG5268; Dmel\\CG5268; Dmel_CG5268; l(3)01618", "gene_names_refseq": "BcDNA:RE11908; Blp; CG5268; Dmel\\CG5268; blp; l(3)01618", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim16; Protein black pearl", "protein_names_refseq": "CG5268-PB; black pearl, isoform B; black pearl; black-pearl; blp-PB", "tax_id": 7227, "disease": "spondylometaphyseal dysplasia Megarbane-Dagher-Melike type (Disease Ontology:DOID:0112304); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (dme:Dmel_CG5268)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;11179663;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Regulates ATP-dependent protein translocation into the mitochondrial matrix (By similarity). Essential for larval development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9GP65", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix;GO:0002168 instar larval development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VF08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VE61-1", "uniprot_id": "RN181_DROME", "mass": 17037.0, "length": 147, "protein_name": "E3 ubiquitin-protein ligase RNF181 homolog", "gene_name": "BcDNA:LP11469", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001138076", "gene_names_uniprotkb": "BcDNA:LP11469; CG7694; Dmel\\CG7694; Dmel_CG7694", "gene_names_refseq": "BcDNA:LP11469; CG7694; Dmel\\CG7694", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF181 homolog; 2.3.2.27; RING finger protein 181 homolog; RING-type E3 ubiquitin transferase RNF181 homolog", "protein_names_refseq": "CG7694-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7694); (R-DME-983168)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0M4;Q8IGZ5", "ec_number_list": "2.3.2.27;2.3.2.25;2.3.2.23;2.3.2.31;2.3.2.26;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VE61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDS5-1", "uniprot_id": "RG92B_DROME", "mass": 83085.0, "length": 740, "protein_name": "Rho GTPase-activating protein 92B", "gene_name": "RhoGAP92B", "organism": "Fruit fly", "refseq_name": "Rho GTPase activating protein at 92B, isoform E", "refseq_ac": "NP_001287417", "gene_names_uniprotkb": "RhoGAP92B; CG4755; Dmel\\CG4755; Dmel_CG4755; dRich; drich", "gene_names_refseq": "CG4755; Dmel\\CG4755; RhoGAP92B; dRich; drich", "protein_names_uniprotkb": "Rho GTPase-activating protein 92B", "protein_names_refseq": "CG4755-PE; Rho GTPase activating protein at 92B, isoform E; RhoGAP92B-PE", "tax_id": 7227, "disease": "lung carcinoma (Disease Ontology:DOID:3905); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); skin melanoma (Disease Ontology:DOID:8923); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dme:Dmel_CG4755); (R-DME-8980692); (R-DME-9013148); (R-DME-9013149); (R-DME-9013406); (R-DME-9013423)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T3Q3", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0007165 signal transduction;GO:0007274 neuromuscular synaptic transmission;GO:0032956 regulation of actin cytoskeleton organization;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VDS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VD51-1", "uniprot_id": "DDX18_DROME", "mass": 76928.0, "length": 680, "protein_name": "Probable ATP-dependent RNA helicase pitchoune", "gene_name": "pit", "organism": "Fruit fly", "refseq_name": "pitchoune, isoform C", "refseq_ac": "NP_001287459", "gene_names_uniprotkb": "pit; CG6375; DDX18; DmRH15; Dmel\\CG6375; Dmel_CG6375; Hel93F; PIT; Pit; hel93F", "gene_names_refseq": "CG6375; DDX18; DmRH15; Dmel\\CG6375; Hel93F; PIT; Pit; hel93F; pit", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase pitchoune; 3.6.4.13", "protein_names_refseq": "CG6375-PC; helicase at 93F; pit-PC; pitchoune, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6375)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9716523", "class_list": "", "function": "Probable RNA-dependent helicase. Functions in cell growth and proliferation. May have a role in ribosome biogenesis and, consequently, in protein biosynthesis., [UniProtKB, PubMed]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V384;O77001;Q8SYP5", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VD51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XZL8-1", "uniprot_id": "SRA_DROME", "mass": 31424.0, "length": 292, "protein_name": "Protein sarah", "gene_name": "sra", "organism": "Fruit fly", "refseq_name": "sarah, isoform B", "refseq_ac": "NP_001287361", "gene_names_uniprotkb": "sra; 89B11; 89B; CG6072; Dmel\\CG6072; Dmel_CG6072; Sarah; Sra; anon-WO0118547.92; anon-WO0172774.10; l(3)05203; nebula; nla", "gene_names_refseq": "89B11; 89B; CG6072; Dmel\\CG6072; Sarah; Sra; anon-WO0118547.92; anon-WO0172774.10; l(3)05203; nebula; nla; sra", "protein_names_uniprotkb": "Protein sarah; Protein nebula", "protein_names_refseq": "CG6072-PB; lethal (3) 05203; nebula; sarah, isoform B; sarah; sara; sra-PB", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (dme:Dmel_CG6072)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15611177;16110336;16860743;16860744;17569856;17569867;22421435;25589440;26109356;26109357", "class_list": "", "function": "Required for elongation of meiosis I spindle. Critical for ovulation, meiotic progression in oocytes and female courtship behavior, including their postmating changes. Regulates female meiosis by controlling calcineurin activity in the germline. Has a role in calcium signaling during egg activation; bcd mRNA polyadenylation and translation in the oocyte., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9V391", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity;GO:0141109 transporter activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0019722 calcium-mediated signaling;GO:0030431 sleep;GO:0007143 female meiotic nuclear division;GO:0007616 long-term memory", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9XZL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VBV3-1", "uniprot_id": "TAKT_DROME", "mass": 27344.0, "length": 249, "protein_name": "Protein takeout", "gene_name": "to", "organism": "Fruit fly", "refseq_name": "takeout, isoform B", "refseq_ac": "NP_001287525", "gene_names_uniprotkb": "to; CG11853; CT33074; Dmel\\CG11853; Dmel_CG11853; JHBP9; Takeout; To", "gene_names_refseq": "CG11853; CT33074; Dmel\\CG11853; JHBP9; Takeout; To; to", "protein_names_uniprotkb": "Protein takeout", "protein_names_refseq": "CG11853-PB; juvenile hormone binding protein 9; take-out; takeout, isoform B; takeout; takeou; to-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11853)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;10892651;10958689;12435630;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Participates in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activities. Involved in male courtship behavior. In the brain-associated fat body, transcription is enhanced by the dsx and fru male-specific isoforms and repressed by the dsx female-specific isoform., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MR66;Q9VBV2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0008049 male courtship behavior;GO:0042595 behavioral response to starvation;GO:0007617 mating behavior;GO:0042594 response to starvation;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VBV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GQN5-1", "uniprot_id": "ATRX_DROME", "mass": 148220.0, "length": 1311, "protein_name": "Chromatin remodeler ATRX homolog", "gene_name": "XNP", "organism": "Fruit fly", "refseq_name": "XNP, isoform B", "refseq_ac": "NP_651398", "gene_names_uniprotkb": "XNP; ATRX; CG4548; DATR-X; DATRX; Dmel\\CG4548; Dmel_CG4548; EP(3)0635; EP635; XNP; Xnp; atr-x; atrx; dATRX; dXNP; datrx; xnp", "gene_names_refseq": "ATR-X/XNP; ATRX; CG4548; DATR-X; DATRX; Dmel\\CG4548; EP(3)0635; EP635; XNP/dATRX; XNP; Xnp; atrx; dATRX; dXNP; datrx; xnp/atr-x; xnp", "protein_names_uniprotkb": "Chromatin remodeler ATRX homolog; 3.6.4.-; Transcriptional regulator XNP; X-linked nuclear protein; d-xnp; dXNP", "protein_names_refseq": "CG4548-PB; XNP, isoform B; XNP-PB", "tax_id": 7227, "disease": "X-linked intellectual disability-hypotonic facies syndrome-1 (Disease Ontology:DOID:0080982); alpha thalassemia-X-linked intellectual disability syndrome (Disease Ontology:DOID:0110030); alpha-thalassemia myelodysplasia syndrome (Disease Ontology:DOID:0112125); intellectual disability (Disease Ontology:DOID:1059); sarcoma (Disease Ontology:DOID:1115); islet cell tumor (Disease Ontology:DOID:1799); melanoma (Disease Ontology:DOID:1909); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (dme:Dmel_CG4548)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;28320872", "class_list": "", "function": "Global transcriptional regulator. Modifies gene expression by affecting chromatin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3E4;Q9VBQ8", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003712 transcription coregulator activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0042585 germinal vesicle", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0006281 DNA repair;GO:0006325 chromatin organization;GO:0097193 intrinsic apoptotic signaling pathway;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9GQN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VB31-1", "uniprot_id": "C6A18_DROME", "mass": 57956.0, "length": 507, "protein_name": "Probable cytochrome P450 6a18", "gene_name": "Cyp6a18", "organism": "Fruit fly", "refseq_name": "cytochrome P450 6a18, isoform B", "refseq_ac": "NP_001287562", "gene_names_uniprotkb": "Cyp6a18; 6a18; CG13977; CYP6a18; Cyp6A18; Dmel\\CG13977; Dmel_CG13977; cyp6a18", "gene_names_refseq": "6a18; CG13977; CYP6a18; Cyp6A18; Cyp6a18; Dmel\\CG13977; cyp6a18", "protein_names_uniprotkb": "Probable cytochrome P450 6a18; 1.14.-.-; CYPVIA18", "protein_names_refseq": "CG13977-PB; Cyp6a18-PB; cytochrome P450 6a18, isoform B; cytochrome P450", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); alcohol-associated liver disease (Disease Ontology:DOID:0070658); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); essential hypertension (Disease Ontology:DOID:10825); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); familial Mediterranean fever (Disease Ontology:DOID:2987); liver cirrhosis (Disease Ontology:DOID:5082); oral submucous fibrosis (Disease Ontology:DOID:5773); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG13977)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VB31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VC57-1", "uniprot_id": "ATLAS_DROME", "mass": 60912.0, "length": 541, "protein_name": "Atlastin", "gene_name": "atl", "organism": "Fruit fly", "refseq_name": "atlastin, isoform C", "refseq_ac": "NP_001287506", "gene_names_uniprotkb": "atl; ATL; Atlastin-1; Atl; CG6668; DATL; Dmel\\CG6668; Dmel_CG6668; dAtl", "gene_names_refseq": "ATL; Atlastin-1; Atl; CG6668; DATL; Dmel\\CG6668; atl; dAtl", "protein_names_uniprotkb": "Atlastin; 3.6.5.-", "protein_names_refseq": "CG6668-PC; D-atlastin; atl-PC; atlastin, isoform C; atlastin", "tax_id": 7227, "disease": "hereditary sensory neuropathy type 1F (Disease Ontology:DOID:0070154); hereditary sensory neuropathy type 1D (Disease Ontology:DOID:0070156); hereditary spastic paraplegia 3A (Disease Ontology:DOID:0110791); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (dme:Dmel_CG6668)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17030474;17569856;17569867;18327897;19341724;19633650;25407413;25589440;26109356;26109357;38509071", "class_list": "", "function": "Membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network (PubMed:19633650, PubMed:38509071). It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (PubMed:19633650, PubMed:25407413). May also regulate more or less directly Golgi biogenesis (PubMed:19341724). May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions (PubMed:19341724)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.5;3.6.5.2;3.6.5.-;3.6.5.3", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0030742 GTP-dependent protein binding;GO:0032561 guanyl ribonucleotide binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0051124 synaptic assembly at neuromuscular junction;GO:0051260 protein homooligomerization;GO:0007517 muscle organ development;GO:0061025 membrane fusion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VC57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VH69-1", "uniprot_id": "RS29_DROME", "mass": 6591.0, "length": 56, "protein_name": "Small ribosomal subunit protein uS14", "gene_name": "RpS29", "organism": "Fruit fly", "refseq_name": "ribosomal protein S29, isoform A", "refseq_ac": "NP_649946", "gene_names_uniprotkb": "RpS29; BcDNA:AT13329; BcDNA:AT28563; BcDNA:RH06643; CG8495; Dmel\\CG8495; Dmel_CG8495; M(3)85E; M(3)LS5; Rps29; S14; anon-EST:fe3B4; anon-WO0118547.360; chr3R:5604479..5604622", "gene_names_refseq": "BcDNA:AT13329; BcDNA:AT28563; BcDNA:RH06643; CG8495; Dmel\\CG8495; M(3)85E; M(3)LS5; RpS29; Rps29; S14; anon-EST:fe3B4; anon-WO0118547.360; chr3R:5604479..5604622", "protein_names_uniprotkb": "Small ribosomal subunit protein uS14; 40S ribosomal protein S29", "protein_names_refseq": "CG8495-PA; RpS29-PA; anon-fast-evolving-3B4; minute (3) 85E; ribosomal protein S29, isoform A", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 13 (Disease Ontology:DOID:0111889)", "pathway": " (dme:Dmel_CG8495); (R-DME-156827); (R-DME-1799339); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 12, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7JYH9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005840 ribosome;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit;GO:0005829 cytosol", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VH69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9TVM2-1", "uniprot_id": "XPO1_DROME", "mass": 122799.0, "length": 1063, "protein_name": "Exportin-1", "gene_name": "emb", "organism": "Fruit fly", "refseq_name": "embargoed, isoform B", "refseq_ac": "NP_001303316", "gene_names_uniprotkb": "emb; CG13387; CRM-1; CRM1; Crm1; DCRM1; Dmel\\CG13387; Dmel_CG13387; EN2-1; Emb; XPO-1; XPO1; Xpo1; crm1; dCRM1; dXPO1; l(2)k16715; xpo1", "gene_names_refseq": "CG13387; CRM-1; CRM1; Crm1; DCRM1; Dmel\\CG13387; EN2-1; Emb; XPO-1; XPO1; Xpo1; crm1; dCRM1; dXPO1; emb; l(2)k16715; xpo1", "protein_names_uniprotkb": "Exportin-1; Chromosome region maintenance 1 protein; Protein embargoed", "protein_names_refseq": "CG13387-PB; Exportin-1; chromosomal region maintenance 1; emb-PB; embargoed, isoform B; embargoed; enhancer of NA9 2-1; exportin", "tax_id": 7227, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); extrahepatic bile duct carcinoma (Disease Ontology:DOID:4682); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG13387); (R-DME-3769402); (R-DME-450520); (R-DME-69273); (R-DME-9634638); (R-DME-9707616); (R-DME-9856649)", "pathway_count": 7, "publication_count": 19, "publication_id_list": "10636888;10731132;10924475;12537568;12537569;12537572;12537573;12537574;14638854;16103875;16110336;17032737;17569856;17569867;25589440;25858587;26109356;26109357;31626769", "class_list": "", "function": "Receptor for the leucine-rich nuclear export signal (NES) (PubMed:10636888, PubMed:14638854, PubMed:16103875). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form (PubMed:10636888, PubMed:14638854). Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm (PubMed:14638854, PubMed:17032737, PubMed:25858587). Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae (PubMed:31626769). Required for the function or maintenance of certain tissues such as brain and gut (PubMed:10924475)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9I7N7;Q9U699", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0015031 protein transport;GO:0051168 nuclear export;GO:1900037 regulation of cellular response to hypoxia;GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9TVM2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W5A5-1", "uniprot_id": "TTYH2_DROME", "mass": 71406.0, "length": 655, "protein_name": "Protein movement modulator", "gene_name": "Motor", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform F", "refseq_ac": "NP_001245460", "gene_names_uniprotkb": "Motor; BG00376; CG3638; Dmel\\CG3638; Dmel_CG3638; EG:33C11.3; TTYH2", "gene_names_refseq": "BG00376; CG3638; Dmel\\CG3638; EG:33C11.3; TTYH2", "protein_names_uniprotkb": "Protein movement modulator; Dttyh2; Protein tweety-2", "protein_names_refseq": "BG00376; CG3638-PF; tweety-2; uncharacterized protein, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3638); (R-DME-2672351)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537572;12537573;12537574;16110336;16219661;17569856;17569867;18327897;25589440;26109356;26109357;38869942", "class_list": "", "function": "Probable chloride channel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Probable large-conductance Ca(2+)-activated chloride channel (By similarity). Modulator of embryonic movement (PubMed:38869942)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A8WHI0;O97175;Q8IRY1;Q8IRY2;Q8IRY3;Q9U1L5", "ec_number_list": "", "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0040013 negative regulation of locomotion;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9W5A5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VXY2-1", "uniprot_id": "MADD_DROME", "mass": 226055.0, "length": 2084, "protein_name": "MAP kinase-activating death domain protein", "gene_name": "Rab3-GEF", "organism": "Fruit fly", "refseq_name": "Rab3 GDP-GTP exchange factor, isoform C", "refseq_ac": "NP_573001", "gene_names_uniprotkb": "Rab3-GEF; BEST:GH21304; CG5627; Dmel\\CG5627; Dmel_CG5627; anon-EST:Posey246; rab3-GEF; rab3-gef", "gene_names_refseq": "BEST:GH21304; CG5627; Dmel\\CG5627; Rab3-GEF; anon-EST:Posey246; rab3-GEF; rab3-gef", "protein_names_uniprotkb": "MAP kinase-activating death domain protein; Rab3 guanyl-nucleotide exchange factor", "protein_names_refseq": "CG5627-PC; Rab3 GDP-GTP exchange factor, isoform C; Rab3-GEF-PC; rab3-GEF", "tax_id": 7227, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG5627); (R-DME-8876198)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;10798391;11563850;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;25589440;26109356;26109357;33925313", "class_list": "", "function": "Guanyl-nucleotide exchange factor that regulates small GTPases (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSD8", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043195 terminal bouton", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0048789 cytoskeletal matrix organization at active zone;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VXY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGS2-1", "uniprot_id": "TCTP_DROME", "mass": 19637.0, "length": 172, "protein_name": "Translationally-controlled tumor protein homolog", "gene_name": "Tctp", "organism": "Fruit fly", "refseq_name": "translationally controlled tumor protein, isoform B", "refseq_ac": "NP_001303431", "gene_names_uniprotkb": "Tctp; CG4800; Dmel\\CG4800; Dmel_CG4800; TCTP; dTCTP", "gene_names_refseq": "CG4800; Dmel\\CG4800; TCTP; Tctp; dTCTP", "protein_names_uniprotkb": "Translationally-controlled tumor protein homolog; TCTP", "protein_names_refseq": "CG4800-PB; Tctp-PB; translationally controlled tumor protein ortholog; translationally controlled tumor protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4800)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Involved in calcium binding and microtubule stabilization., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q49UC2;Q95TW0", "ec_number_list": "", "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005881 cytoplasmic microtubule;GO:0005700 polytene chromosome", "go_biological_process": "GO:0006302 double-strand break repair;GO:0045793 positive regulation of cell size;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0040018 positive regulation of multicellular organism growth;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VGS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3G6-1", "uniprot_id": "CNO10_DROME", "mass": 69693.0, "length": 635, "protein_name": "CCR4-NOT transcription complex subunit 10", "gene_name": "Not10", "organism": "Fruit fly", "refseq_name": "CCR4-NOT transcription complex subunit 10, isoform B", "refseq_ac": "NP_001303491", "gene_names_uniprotkb": "Not10; CG18616; Dmel\\CG18616; Dmel_CG18616; NOT10; dNot10", "gene_names_refseq": "CG18616; Dmel\\CG18616; NOT10; Not10; dNot10", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 10; CNOT10", "protein_names_refseq": "CCR4-NOT transcription complex subunit 10, isoform B; CG18616-PB; Not10-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18616)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;20504953;23303381;25589440;26109356;26109357", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZP3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9V3G6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJE5-1", "uniprot_id": "CL190_DROME", "mass": 189065.0, "length": 1690, "protein_name": "Restin homolog", "gene_name": "CLIP-190", "organism": "Fruit fly", "refseq_name": "cytoplasmic linker protein 190, isoform A", "refseq_ac": "NP_609835", "gene_names_uniprotkb": "CLIP-190; CG5020; CLIP190; Clip- 190; Clip-190; Clip190; D-CLIP-190; D-CLIP-195; D-CLIP-19; D-CLIP-90; D-Clip-190; Dmel\\CG5020; Dmel_CG5020; clip-190; clip190", "gene_names_refseq": "CG5020; CLIP-190; CLIP190; Clip- 190; Clip-190; Clip190; D-CLIP-190; D-CLIP-195; D-CLIP-19; D-CLIP-90; D-Clip-190; Dmel\\CG5020; clip-190; clip190", "protein_names_uniprotkb": "Restin homolog; Cytoplasmic linker protein 190; Microtubule-binding protein 190; d-CLIP-190", "protein_names_refseq": "CG5020-PA; CLIP-190-PA; cytoplasmic linker protein 190, isoform A; cytoplasmic linker protein 190; cytoplasmic linker protein-190", "tax_id": 7227, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (dme:Dmel_CG5020)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11076973;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;32066907;9472041", "class_list": "", "function": "Together CLIP-190 and jar may coordinate the interaction between the actin and microtubule cytoskeleton. May link endocytic vesicles to microtubules. May play a role in formation of furrows during cellularization., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O44929;Q8INY8;Q8MSD0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0051010 microtubule plus-end binding;GO:0070854 myosin VI heavy chain binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm;GO:0005815 microtubule organizing center;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0007349 cellularization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VJE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VTG7-1", "uniprot_id": "B3G2P_DROME", "mass": 52556.0, "length": 479, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P", "gene_name": "GlcAT-P", "organism": "Fruit fly", "refseq_name": "glucuronyltransferase P, isoform C", "refseq_ac": "NP_001014581", "gene_names_uniprotkb": "GlcAT-P; CG6207; DGlcAT-P; DmGlcAT-BSII; Dmel\\CG6207; Dmel_CG6207; GLCAT-BSII; dGlcAT-BSII; dGlcAT-P", "gene_names_refseq": "CG6207; DGlcAT-P; DmGlcAT-BSII; Dmel\\CG6207; GlcAT-P; dGlcAT-BSII; dGlcAT-P", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P; 2.4.1.135; Beta-1,3-glucuronyltransferase P; DmGlcAT-BSII; GlcAT-P; Glucuronosyltransferase P; UDP-glucuronosyltransferase P", "protein_names_refseq": "CG6207-PC; GlcAT-P-PC; beta1,3-glucuronyltransferase-P; glucuronyltransferase P, isoform C", "tax_id": 7227, "disease": "schizophrenia (Disease Ontology:DOID:5419); Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (dme:Dmel_CG6207); (R-DME-1971475)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12511570;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5BI43;Q8MSC2;Q95RU4", "ec_number_list": "2.4.1.135", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0046987 N-acetyllactosamine beta-1,3-glucuronosyltransferase activity;GO:0046988 asioloorosomucoid beta-1,3-glucuronosyltransferase activity;GO:0046989 galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VTG7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3K5-1", "uniprot_id": "GSH1_DROME", "mass": 80746.0, "length": 717, "protein_name": "Glutamate--cysteine ligase", "gene_name": "Gclc", "organism": "Fruit fly", "refseq_name": "Glutamate-cysteine ligase catalytic subunit, isoform C", "refseq_ac": "NP_001285001", "gene_names_uniprotkb": "Gclc; 2259; CG2259; DmGCLC; DmGCSh; DmGCS; Dmel\\CG2259; Dmel_CG2259; GCLC; GCLc; GCL; GCSh; GclC; Gcsh; Gcs; gclC; gclc; mTOR", "gene_names_refseq": "2259; CG2259; DmGCLC; DmGCSh; DmGCS; Dmel\\CG2259; GCLC; GCLc; GCL; GCSh; GclC; Gclc; Gcsh; Gcs; gclC; gclc; mTOR", "protein_names_uniprotkb": "Glutamate--cysteine ligase; 6.3.2.2; GCS; Gamma-ECS; Gamma-glutamylcysteine synthetase", "protein_names_refseq": "CG2259-PC; Gclc-PC; Glutamate-cysteine ligase catalytic subunit, isoform C; catalytic subunit of glutamate- cysteine ligase; gamma-Glutamylcysteine synthetase catalytic subunit; gamma-glutamylcysteine ligase; glutamate cysteine ligase; glutamate-cysteine ligase", "tax_id": 7227, "disease": "congenital nonspherocytic hemolytic anemia 7 (Disease Ontology:DOID:0111681); cystic fibrosis (Disease Ontology:DOID:1485); liver cirrhosis (Disease Ontology:DOID:5082); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cataract (Disease Ontology:DOID:83); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dme:Dmel_CG2259); (R-DME-174403)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10675565;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NGQ3", "ec_number_list": "6.3.2.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004357 glutamate-cysteine ligase activity", "go_cellular_component": "GO:0017109 glutamate-cysteine ligase complex;GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0007409 axonogenesis;GO:0046688 response to copper ion;GO:0006749 glutathione metabolic process;GO:0007476 imaginal disc-derived wing morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W3K5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NHV9-1", "uniprot_id": "VAV_DROME", "mass": 91355.0, "length": 793, "protein_name": "Protein vav", "gene_name": "Vav", "organism": "Fruit fly", "refseq_name": "Vav guanine nucleotide exchange factor, isoform A", "refseq_ac": "NP_573372", "gene_names_uniprotkb": "Vav; BcDNA:GH01128; CG7893; DmVav; Dmel\\CG7893; Dmel_CG7893; DroVav; vav", "gene_names_refseq": "BcDNA:GH01128; CG7893; DmVav; Dmel\\CG7893; DroVav; Vav; vav", "protein_names_uniprotkb": "Protein vav; DroVav; dVAV", "protein_names_refseq": "CG7893-PA; Vav guanine nucleotide exchange factor, isoform A; Vav ortholog; Vav-PA", "tax_id": 7227, "disease": "endometriosis (Disease Ontology:DOID:289); lymphopenia (Disease Ontology:DOID:614); hepatocellular carcinoma (Disease Ontology:DOID:684); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG7893); (R-DME-114604); (R-DME-1257604); (R-DME-1433557); (R-DME-193648); (R-DME-2424491); (R-DME-2871796); (R-DME-2871809); (R-DME-3928665); (R-DME-416482); (R-DME-4420097); (R-DME-445144); (R-DME-512988); (R-DME-5218920); (R-DME-6811558); (R-DME-8980692); (R-DME-9013148); (R-DME-9013149); (R-DME-9013423); (R-DME-912631); (R-DME-9748787); (R-DME-983695); (R-DME-9958810)", "pathway_count": 23, "publication_count": 13, "publication_id_list": "10731132;10781813;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. Probably plays a pivotal role as a signal transducer protein during fruit fly development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2RVJ3;A4V4R6;Q8SWT3;Q8T061;Q9VWJ5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007409 axonogenesis;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9NHV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYY2-1", "uniprot_id": "SPCS2_DROME", "mass": 22216.0, "length": 199, "protein_name": "Signal peptidase complex subunit 2", "gene_name": "Spase25", "organism": "Fruit fly", "refseq_name": "spase 25-subunit, isoform B", "refseq_ac": "NP_001285124", "gene_names_uniprotkb": "Spase25; CG1571; CG1751; Dmel\\CG1751; Dmel_CG1751", "gene_names_refseq": "CG1571; CG1751; Dmel\\CG1751; Spase25", "protein_names_uniprotkb": "Signal peptidase complex subunit 2; Microsomal signal peptidase 25 kDa subunit; SPase 25 kDa subunit", "protein_names_refseq": "CG1751-PB; SPase 25-subunit; Spase25-PB; spase 25-subunit, isoform B", "tax_id": 7227, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dme:Dmel_CG1751)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15901661;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008233 peptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VYY2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VTJ8-1", "uniprot_id": "TIM14_DROME", "mass": 12868.0, "length": 118, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM14", "gene_name": "D.M.UKP; TIM14; Tim14", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": "NP_001246717", "gene_names_uniprotkb": "D.M.UKP; TIM14; Tim14; BcDNA:RE52392; CG7394; D.M.UKP; Dmel\\CG7394; Dmel_CG7394; TIM14", "gene_names_refseq": "BcDNA:RE52392; CG7394; D.M.UKP; Dmel\\CG7394; TIM14", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM14", "protein_names_refseq": "CG7394-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "3-methylglutaconic aciduria type 5 (Disease Ontology:DOID:0110000)", "pathway": " (dme:Dmel_CG7394)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYM8", "ec_number_list": "", "go_molecular_function": "GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0001405 PAM complex, Tim23 associated import motor;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VTJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VW97-1", "uniprot_id": "LSDA_DROME", "mass": 98389.0, "length": 890, "protein_name": "Possible lysine-specific histone demethylase 1", "gene_name": "Su(var)3-3", "organism": "Fruit fly", "refseq_name": "suppressor of variegation 3-3, isoform A", "refseq_ac": "NP_649194", "gene_names_uniprotkb": "Su(var)3-3; CG17149; Dmel\\CG17149; Dmel\\LSD1; Dmel_CG17149; HDM; Hdm; LSD1; Lsd1; SU(VAR)3-3; Su(Var)3-3; Su-var(3)3; Suvar(3)3; dLSD1; dLsd1; lsd1", "gene_names_refseq": "CG17149; Dmel/HDM; Dmel/LSD1; Dmel\\CG17149; Dmel\\LSD1; Hdm; LSD1; Lsd1; SU(VAR)3-3; Su(Var)3-3; Su(var)3-3; Su-var(3)3; Suvar(3)3; dLSD1; dLsd1; lsd1", "protein_names_uniprotkb": "Possible lysine-specific histone demethylase 1; 1.-.-.-", "protein_names_refseq": "CG17149-PA; Su(var)3-3-PA; flavoprotein; histone demethylase; histone lysine-specific demethylase 1; lysine-specific demethylase 1; suppressor of variegation 3-3, isoform A", "tax_id": 7227, "disease": "breast cancer (Disease Ontology:DOID:1612); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (dme:Dmel_CG17149); (R-DME-3214815); (R-DME-5625886); (R-DME-9018519); (R-DME-9764725); (R-DME-983231)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15306652;16110336;17434130;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3., [UniProtKB, UniProtKB, UniProtKB]; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for heterochromatic gene silencing. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and tri-methylated 'Lys-4' of histone H3. May also demethylate 'Lys-9' of histone H3, Plays a role in the repression of neuronal genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8C9", "ec_number_list": "2.7.11.1;2.7.11.13;3.6.4.-;3.5.1.98;1.-.-.-;1.14.99.66", "go_molecular_function": "GO:0032453 histone H3K4 demethylase activity;GO:0003682 chromatin binding;GO:0050660 flavin adenine dinucleotide binding;GO:0106222 lncRNA binding;GO:0140682 FAD-dependent H3K4me/H3K4me3 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VW97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W391-1", "uniprot_id": "KPBA_DROME", "mass": 140512.0, "length": 1247, "protein_name": "Probable phosphorylase b kinase regulatory subunit alpha", "gene_name": "Phka", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": "NP_572525", "gene_names_uniprotkb": "Phka; CG7766; Dmel\\CG7766; Dmel_CG7766", "gene_names_refseq": "CG7766; Dmel\\CG7766", "protein_names_uniprotkb": "Probable phosphorylase b kinase regulatory subunit alpha; Phosphorylase kinase subunit alpha", "protein_names_refseq": "CG7766-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); glycogen storage disease IXd (Disease Ontology:DOID:0111040); glycogen storage disease IXa1 (Disease Ontology:DOID:0111042); hypothyroidism (Disease Ontology:DOID:1459); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (dme:Dmel_CG7766); (R-DME-70221)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q86B60;Q95TZ6", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W391-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAI6-1", "uniprot_id": "OB99B_DROME", "mass": 17188.0, "length": 149, "protein_name": "General odorant-binding protein 99b", "gene_name": "Obp99b", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 99b, isoform B", "refseq_ac": "NP_001263078", "gene_names_uniprotkb": "Obp99b; 99b; BcDNA:LP06572; CG7592; DmelObp99b; Dmel\\CG7592; Dmel_CG7592; OBP99b; Obp99d; obp99b; tsx", "gene_names_refseq": "99b; BcDNA:LP06572; CG7592; DmelObp99b; Dmel\\CG7592; OBP99b; Obp99b; Obp99d; obp99b; tsx", "protein_names_uniprotkb": "General odorant-binding protein 99b", "protein_names_refseq": "CG7592-PB; Obp99b-PB; Odorant-binding protein 99b, isoform B; Odordant-binding protein 99b; general odorant-binding protein 99b precursor; odorant binding protein 99b; turn on sex-specificity", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7592)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;11729153;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17720903;25589440;26109356;26109357", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9QJ16;A9QJ18;A9QJ19;A9QJ29;A9QJ60;A9QJ64;A9QJ66;A9QJD0;A9QJD5;A9QJE9;A9QJI9", "ec_number_list": "", "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VAI6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V345-1", "uniprot_id": "CSN4_DROME", "mass": 46473.0, "length": 407, "protein_name": "COP9 signalosome complex subunit 4", "gene_name": "CSN4", "organism": "Fruit fly", "refseq_name": "COP9 signalosome subunit 4, isoform B", "refseq_ac": "NP_001163080", "gene_names_uniprotkb": "CSN4; CG8725; CH4; Cops4; Csn4; DCH4; Dch4; Dmel\\CG8725; Dmel_CG8725; csn4; l(2)k08018", "gene_names_refseq": "CG8725; CH4; CSN4; Cops4; Csn4; DCH4; Dch4; Dmel\\CG8725; csn4; l(2)k08018", "protein_names_uniprotkb": "COP9 signalosome complex subunit 4; Dch4; Signalosome subunit 4", "protein_names_refseq": "CG8725-PB; COP9 complex homolog subunit 4; COP9 signalosome subunit 4, isoform B; CSN4-PB; drosophila COP9 signalosome homolog 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8725); (R-DME-5696394); (R-DME-6781823); (R-DME-8856825); (R-DME-8951664); (R-DME-9013422)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10531038;10731132;12223399;12537568;12537572;12537573;12537574;12737805;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9XYW5", "ec_number_list": "", "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0050821 protein stabilization;GO:0007281 germ cell development;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048477 oogenesis;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9V345-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLA1-1", "uniprot_id": "B3G2S_DROME", "mass": 46711.0, "length": 409, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase S", "gene_name": "GlcAT-S", "organism": "Fruit fly", "refseq_name": "glucuronyltransferase S, isoform B", "refseq_ac": "NP_609303", "gene_names_uniprotkb": "GlcAT-S; CG3881; DGlcAT-S; DmGlcAT-BSI; Dmel\\CG3881; Dmel_CG3881; GLCAT-BSI; dGlcAT-BSI; dGlcAT-S", "gene_names_refseq": "CG3881; DGlcAT-S; DmGlcAT-BSI; Dmel\\CG3881; GlcAT-S; dGlcAT-BSI; dGlcAT-S", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase S; 2.4.1.135; Beta-1,3-glucuronyltransferase S; DmGlcAT-BSI; GlcAT-S; Glucuronosyltransferase S; UDP-glucuronosyltransferase S", "protein_names_refseq": "CG3881-PB; GlcAT-S-PB; glucuronyltransferase S, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3881); (R-DME-1971475)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12511570;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q868Q3;Q8IPE6;Q95U07", "ec_number_list": "2.4.1.135", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015020 glucuronosyltransferase activity;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0046987 N-acetyllactosamine beta-1,3-glucuronosyltransferase activity;GO:0046988 asioloorosomucoid beta-1,3-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VLA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVT2-1", "uniprot_id": "INDY1_DROME", "mass": 65585.0, "length": 590, "protein_name": "Protein I'm not dead yet", "gene_name": "Indy", "organism": "Fruit fly", "refseq_name": "I'm not dead yet, isoform D", "refseq_ac": "NP_001163465", "gene_names_uniprotkb": "Indy; BEST:LP01220; CG3979; Dmel\\CG3979; Dmel_CG3979; INDY; anon-EST:fe3A7; anon-WO0172774.70; drIndy; indy", "gene_names_refseq": "BEST:LP01220; CG3979; Dmel\\CG3979; INDY; Indy; anon-EST:fe3A7; anon-WO0172774.70; drIndy; indy", "protein_names_uniprotkb": "Protein I'm not dead yet; INDY transporter protein; drIndy", "protein_names_refseq": "CG3979-PD; I am not dead yet; I'm Not dead Yet; I'm not dead yet, isoform D; Indy-PD; anon-fast-evolving-3A7", "tax_id": 7227, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667); developmental and epileptic encephalopathy 25 (Disease Ontology:DOID:0080453); Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG3979); (R-DME-433137); (R-DME-9955298)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10581279;10731132;11118146;12186628;12391301;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A4V236;Q7KUS6;Q9NHY9", "ec_number_list": "", "go_molecular_function": "GO:0015137 citrate transmembrane transporter activity;GO:0050833 pyruvate transmembrane transporter activity;GO:0015141 succinate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015746 citrate transport;GO:0008340 determination of adult lifespan;GO:0015744 succinate transport;GO:0006848 pyruvate transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VVT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWA1-1", "uniprot_id": "CLC_DROME", "mass": 23840.0, "length": 219, "protein_name": "Clathrin light chain", "gene_name": "Clc", "organism": "Fruit fly", "refseq_name": "clathrin light chain, isoform B", "refseq_ac": "NP_001163480", "gene_names_uniprotkb": "Clc; CG6948; CLC; Dmel\\CG6948; Dmel_CG6948; clc1; clc", "gene_names_refseq": "CG6948; CLC; Clc; Dmel\\CG6948; clc1; clc", "protein_names_uniprotkb": "Clathrin light chain; dClc", "protein_names_refseq": "CG6948-PB; Clc-PB; clathrin light chain, isoform B; clathrin light chain; clathrin light-chain; clathrin-light-chain", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6948); (R-DME-177504); (R-DME-190873); (R-DME-196025); (R-DME-3928665); (R-DME-432720); (R-DME-432722); (R-DME-437239); (R-DME-5099900); (R-DME-5140745); (R-DME-8856825); (R-DME-8856828); (R-DME-8866427); (R-DME-8964038)", "pathway_count": 14, "publication_count": 13, "publication_id_list": "10098605;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O61647", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VWA1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VE86-1", "uniprot_id": "WRNXO_DROME", "mass": 40293.0, "length": 353, "protein_name": "3'-5' exonuclease", "gene_name": "WRNexo", "organism": "Fruit fly", "refseq_name": "WRN exonuclease, isoform B", "refseq_ac": "NP_001163646", "gene_names_uniprotkb": "WRNexo; CG7670; DmWRNexo; Dmel\\CG7670; Dmel_CG7670; Wrnexo", "gene_names_refseq": "CG7670; DmWRNexo; Dmel\\CG7670; WRNexo; Wrnexo", "protein_names_uniprotkb": "3'-5' exonuclease; 3.1.11.-; DmWRNexo; Werner Syndrome-like exonuclease", "protein_names_refseq": "CG7670-PB; WRN exonuclease, isoform B; WRNexo-PB", "tax_id": 7227, "disease": "Werner syndrome (Disease Ontology:DOID:5688)", "pathway": " (dme:Dmel_CG7670)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18056975;18327897;18346216;18956248;25589440;26109356;26109357", "class_list": "", "function": "Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction (PubMed:18056975, PubMed:18346216, PubMed:18956248). Essential for the formation of DNA replication focal centers (PubMed:18346216, PubMed:18956248). Has an important role in maintaining genome stability (PubMed:18346216, PubMed:18956248)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7L742;B6IDR2;Q961E1", "ec_number_list": "", "go_molecular_function": "GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity;GO:0008408 3'-5' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045950 negative regulation of mitotic recombination;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VE86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR81-1", "uniprot_id": "NAGA_DROME", "mass": 45283.0, "length": 417, "protein_name": "N-acetylglucosamine-6-phosphate deacetylase", "gene_name": "Dmel\\CG17065", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform D", "refseq_ac": "NP_001285488", "gene_names_uniprotkb": "Dmel\\CG17065; Amdhd2; CG17065; Dmel_CG17065", "gene_names_refseq": "Amdhd2; CG17065; Dmel\\CG17065", "protein_names_uniprotkb": "N-acetylglucosamine-6-phosphate deacetylase; 3.5.1.25; GlcNAc 6-P deacetylase", "protein_names_refseq": "CG17065-PD; uncharacterized protein, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17065); (R-DME-446210)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.25", "go_molecular_function": "GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006046 N-acetylglucosamine catabolic process;GO:0019262 N-acetylneuraminate catabolic process;GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process;GO:0006044 N-acetylglucosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VR81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9U6B8-1", "uniprot_id": "ORAI1_DROME", "mass": 38507.0, "length": 351, "protein_name": "Calcium release-activated calcium channel protein 1", "gene_name": "Orai", "organism": "Fruit fly", "refseq_name": "orai, isoform E", "refseq_ac": "NP_001137696", "gene_names_uniprotkb": "Orai; BcDNA:LD03241; CG11430; CRACM1; DOrai; Dmel\\CG11430; Dmel_CG11430; ORAI1; ORAI; Olf186-F; Orai1; dOrai1; dOrai; dorai; l(2)k11505; olf186-F; orai", "gene_names_refseq": "BcDNA:LD03241; CG11430; CRACM1; DOrai; Dmel\\CG11430; ORAI1; ORAI; Olf186-F; Orai1; Orai; dOrai1; dOrai; dorai; l(2)k11505; olf186-F; orai", "protein_names_uniprotkb": "Calcium release-activated calcium channel protein 1; Protein orai", "protein_names_refseq": "CG11430-PE; CRAC modulator 1; Orai-PE; lethal (2) k11505; olf186-F; orai, isoform E", "tax_id": 7227, "disease": "Stormorken syndrome (Disease Ontology:DOID:0060354); tubular aggregate myopathy 2 (Disease Ontology:DOID:0080686); immunodeficiency 9 (Disease Ontology:DOID:0111976); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dme:Dmel_CG11430)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16582901;16645049;16751269;16921383;17569856;17569867;23180775;25589440;26109356;26109357", "class_list": "", "function": "Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles in hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor Stim, a process known as store-operated Ca(2+) entry (SOCE). Regulates transcription factor NFAT nuclear import., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7YZJ7;Q0E937;Q1HCN1;Q7JQY5;Q7KRH6;Q8IGA6;Q9V892", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0005246 calcium channel regulator activity;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034704 calcium channel complex", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0070886 positive regulation of calcineurin-NFAT signaling cascade;GO:0051928 positive regulation of calcium ion transport;GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9U6B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V4A7-1", "uniprot_id": "PLXB_DROME", "mass": 231680.0, "length": 2051, "protein_name": "Plexin-B", "gene_name": "PlexB", "organism": "Fruit fly", "refseq_name": "plexin B, isoform B", "refseq_ac": "NP_001245400", "gene_names_uniprotkb": "PlexB; CG17245; Dmel\\CG17245; Dmel_CG17245; PLEXB; Plex B; plex B; plexB; plex", "gene_names_refseq": "CG17245; Dmel\\CG17245; PLEXB; Plex B; PlexB; plex B; plexB; plex", "protein_names_uniprotkb": "Plexin-B", "protein_names_refseq": "CG17245-PB; PlexB-PB; Plexin-B; PlexinB; plexin B, isoform B; plexin B; plexin and met-hepatocyte growth factor receptor-like", "tax_id": 7227, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); DiGeorge syndrome (Disease Ontology:DOID:11198); transient cerebral ischemia (Disease Ontology:DOID:224); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG17245); (R-DME-416482); (R-DME-416572); (R-DME-416700)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10731132;11604137;12537568;12537572;12537573;12537574;16110336;16672342;17569856;17569867;25589440;26109356;26109357;27618755;29520219;37041188;9875845", "class_list": "", "function": "Transmembrane receptor that binds the molecular guidance cue Sema2a, to regulate axon guidance and possibly salivary gland positioning in embryos (PubMed:11604137, PubMed:16672342). Acts as a receptor for Sema2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity (PubMed:11604137, PubMed:16672342). As transmembrane receptor for Sema2a, involved in peripheral and central nervous system axon guidance (PubMed:11604137, PubMed:16672342, PubMed:27618755). Function in neurons is essential for adult survival, motor neuron survival, and is important for climbing behavior and activity (PubMed:37041188). During embryogenesis, plays an important role in correct salivary gland positioning (PubMed:27618755)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "O96682", "ec_number_list": "", "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0120025 plasma membrane bounded cell projection", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9V4A7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NJB5-1", "uniprot_id": "ONEC_DROME", "mass": 117698.0, "length": 1081, "protein_name": "Homeobox protein onecut", "gene_name": "onecut", "organism": "Fruit fly", "refseq_name": "onecut, isoform B", "refseq_ac": "NP_001259065", "gene_names_uniprotkb": "onecut; A1; CG1922; Dmel\\CG1922; Dmel_CG1922; Onecut", "gene_names_refseq": "A1; CG1922; Dmel\\CG1922; Onecut; onecut", "protein_names_uniprotkb": "Homeobox protein onecut", "protein_names_refseq": "CG1922-PB; D-onecut; onecut, isoform B; onecut-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1922)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Transcriptional regulator. Binds and recognize ATTG sites., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9V4E4", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9NJB5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLF6-1", "uniprot_id": "U585_DROME", "mass": 24887.0, "length": 222, "protein_name": "UPF0585 protein CG18661", "gene_name": "BcDNA:SD17344", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": "NP_652562", "gene_names_uniprotkb": "BcDNA:SD17344; CG18661; Dmel\\CG18661; Dmel_CG18661; METTL26; Mettl26", "gene_names_refseq": "BcDNA:SD17344; CG18661; Dmel\\CG18661; METTL26; Mettl26", "protein_names_uniprotkb": "UPF0585 protein CG18661", "protein_names_refseq": "CG18661-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18661)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRW6", "ec_number_list": "", "go_molecular_function": "GO:0008168 methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VLF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0I6-1", "uniprot_id": "SAC1_DROME", "mass": 67768.0, "length": 592, "protein_name": "Phosphatidylinositol-3-phosphatase SAC1", "gene_name": "Sac1", "organism": "Fruit fly", "refseq_name": "Sac1 phosphatase, isoform B", "refseq_ac": "NP_001189016", "gene_names_uniprotkb": "Sac1; CG9128; Dmel\\CG9128; Dmel_CG9128; Sacm1l; dsac1; impatent; l(3)2107; sac1", "gene_names_refseq": "CG9128; Dmel\\CG9128; Sac1; dsac1; impatent; l(3)2107; sac1", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphatase SAC1; 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein", "protein_names_refseq": "CG9128-PB; Sac1 phosphatase, isoform B; Sac1-PB; impatent; suppressor of actin-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9128); (R-DME-1483248); (R-DME-1660514)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.-;3.1.3.64", "go_molecular_function": "GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0016791 phosphatase activity;GO:0052866 phosphatidylinositol phosphate phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008088 axo-dendritic transport;GO:0016199 axon midline choice point recognition;GO:0046329 negative regulation of JNK cascade;GO:0046856 phosphatidylinositol dephosphorylation;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W0I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMP9-1", "uniprot_id": "GNPI_DROME", "mass": 30824.0, "length": 273, "protein_name": "Glucosamine-6-phosphate deaminase", "gene_name": "Gnpda", "organism": "Fruit fly", "refseq_name": "oscillin, isoform C", "refseq_ac": "NP_001245894", "gene_names_uniprotkb": "Gnpda; CG6957; Dmel\\CG6957; Dmel_CG6957; Gnpda1; Oscillin", "gene_names_refseq": "CG6957; Dmel\\CG6957; Oscillin", "protein_names_uniprotkb": "Glucosamine-6-phosphate deaminase; 3.5.99.6; GNPI; GlcN6P deaminase; Glucosamine-6-phosphate isomerase; Protein oscillin", "protein_names_refseq": "CG6957-PC; Oscillin-PC; oscillin, isoform C; oscillin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6957); (R-DME-70171)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;10964516;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9NE92", "ec_number_list": "3.5.99.6", "go_molecular_function": "GO:0004342 glucosamine-6-phosphate deaminase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0006043 glucosamine catabolic process;GO:0006046 N-acetylglucosamine catabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VMP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VQ37-1", "uniprot_id": "RIM2_DROME", "mass": 40476.0, "length": 365, "protein_name": "Mitochondrial carrier protein Rim2", "gene_name": "Rim2", "organism": "Fruit fly", "refseq_name": "replication in mitochondria 2, isoform A", "refseq_ac": "NP_608615", "gene_names_uniprotkb": "Rim2; CG18317; Dmel\\CG18317; Dmel_CG18317; drim2", "gene_names_refseq": "CG18317; Dmel\\CG18317; Rim2; drim2", "protein_names_uniprotkb": "Mitochondrial carrier protein Rim2", "protein_names_refseq": "CG18317-PA; Rim2 ortholog; Rim2-PA; replication in mitochondria 2, isoform A", "tax_id": 7227, "disease": "familial hyperinsulinemic hypoglycemia 8 (Disease Ontology:DOID:0081328)", "pathway": " (dme:Dmel_CG18317)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;24469456;25589440;26109356;26109357", "class_list": "", "function": "Mitochondrial transporter that imports purine and pyrimidine nucleotides into the mitochondria. Essential for maintaining mitochondrial structure and function. Appears to be important for mitochondrial gene transcription and mitochondrial respiration., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95TJ5", "ec_number_list": "", "go_molecular_function": "GO:0015218 pyrimidine nucleotide transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1990519 pyrimidine nucleotide import into mitochondrion;GO:0030302 deoxynucleotide transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VQ37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0R5-1", "uniprot_id": "MTH10_DROME", "mass": 67406.0, "length": 585, "protein_name": "Probable G protein-coupled receptor Mth-like 10", "gene_name": "mthl10", "organism": "Fruit fly", "refseq_name": "methuselah-like 10, isoform A", "refseq_ac": "NP_612030", "gene_names_uniprotkb": "mthl10; CG17061; Dmel\\CG17061; Dmel_CG17061; Mthl10; anon-WO0170980.166; anon-WO0170980.167; mth2; mthl-10", "gene_names_refseq": "CG17061; Dmel\\CG17061; Mthl10; anon-WO0170980.166; anon-WO0170980.167; mth2; mthl-10; mthl10", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 10; Protein methuselah-like 10", "protein_names_refseq": "CG17061-PA; Methuselah-like 10; Methuselah-like10; Mth-like 10; methuselah-like 10, isoform A; mthl10-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17061)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10908591;12537568;12537572;12537573;12537574;12694290;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q7YWL1;Q86BK3;Q95NU7;Q95YN4", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W0R5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VZD5-1", "uniprot_id": "RT06_DROME", "mass": 17015.0, "length": 147, "protein_name": "Small ribosomal subunit protein bS6m", "gene_name": "mRpS6", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein S6, isoform B", "refseq_ac": "NP_001246623", "gene_names_uniprotkb": "mRpS6; BcDNA:RH10862; CG15016; Dmel\\CG15016; Dmel_CG15016; MRP-S6; Mrps6", "gene_names_refseq": "BcDNA:RH10862; CG15016; Dmel\\CG15016; MRP-S6; Mrps6; mRpS6", "protein_names_uniprotkb": "Small ribosomal subunit protein bS6m; 28S ribosomal protein S6, mitochondrial; MRP-S6; S6mt", "protein_names_refseq": "CG15016-PB; mRpS6-PB; mitochondrial ribosomal protein S6, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15016); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005737 cytoplasm;GO:0005840 ribosome", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VZD5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVG6-1", "uniprot_id": "COQ4_DROME", "mass": 30743.0, "length": 268, "protein_name": "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial", "gene_name": "Coq4", "organism": "Fruit fly", "refseq_name": "coenzyme Q4, isoform D", "refseq_ac": "NP_001246815", "gene_names_uniprotkb": "Coq4; CG32174; CG3877; Dmel\\CG32174; Dmel_CG32174", "gene_names_refseq": "CG32174; CG3877; Coq4; Dmel\\CG32174", "protein_names_uniprotkb": "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; 4.1.1.130; Coenzyme Q biosynthesis protein 4 homolog", "protein_names_refseq": "CG32174-PD; Coq4-PD; coenzyme Q4, isoform D", "tax_id": 7227, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); spastic ataxia (Disease Ontology:DOID:0050952); primary coenzyme Q10 deficiency 7 (Disease Ontology:DOID:0070244)", "pathway": " (dme:Dmel_CG32174); (R-DME-2142789)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z065", "ec_number_list": "2.1.1.-;2.1.1.114;2.1.1.64;1.14.15.45;1.14.15.46;4.1.1.130;2.1.1.201;1.14.99.60", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0120539 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VVG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I7U4-1", "uniprot_id": "TITIN_DROME", "mass": 2065766.0, "length": 18141, "protein_name": "Titin", "gene_name": "sls", "organism": "Fruit fly", "refseq_name": "sallimus, isoform A", "refseq_ac": "NP_524676", "gene_names_uniprotkb": "sls; 01; CG18242; CG18245; CG18857; CG1915; CT41299; D-Titin; D-titin; Dmel\\CG1915; Dmel_CG1915; KZ; Kettin; Ket; MCP; SLS; Sls; TITIN; Titin; anon-CREST; d-titin; kettin; ket; l(3)62Ca; l(3)Ca; l(3)S002001; l(3)dre8; l(3)j1D7; l(3)rL182; sal; sam; titin", "gene_names_refseq": "0020/01; CG18242; CG18245; CG18857; CG1915; CT41299; D-Titin; D-titin; Dmel\\CG1915; KZ; Kettin; Ket; MCP; SLS; Sls; TITIN; Titin; anon-CREST; d-titin; kettin; ket; l(3)62Ca; l(3)Ca; l(3)S002001; l(3)dre8; l(3)j1D7; l(3)rL182; sal; sam; sls/kettin; sls; titin", "protein_names_uniprotkb": "Titin; D-Titin; Kettin", "protein_names_refseq": "CG1915-PA; D-Titin/Kettin; D-titan; D-titin-KZ; D-titin; dtitin; kettin; lethal (3) S002001; lethal(3)62Ca; mitotic chromosomal protein; salimus; sallimus, isoform A; sallimus; sls-PA", "tax_id": 7227, "disease": "myofibrillar myopathy 3 (Disease Ontology:DOID:0080094); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dme:Dmel_CG1915); (R-DME-5658623)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10629221;10669599;10731132;10934048;11062264;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22467859;22927463;25589440;26109356;26109357;26251439;8335002;9548712;9917396", "class_list": "", "function": "Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O76275;O76276;O76277;O76278;O96767;O96768;Q7KA82;Q7KAJ1;Q7KPQ8;Q7RTL4;Q8T3N3;Q9N2P7;Q9N680;Q9N9Y5;Q9N9Y6;Q9N9Y7;Q9NFS3;Q9NJP4;Q9NL88;Q9UB79;Q9W055;Q9XZT9", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008307 structural constituent of muscle;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0030017 sarcomere;GO:0031674 I band;GO:0030018 Z disc;GO:0005863 striated muscle myosin thick filament", "go_biological_process": "GO:0007525 somatic muscle development;GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0007520 myoblast fusion;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9I7U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W5E0-1", "uniprot_id": "SUV42_DROME", "mass": 137525.0, "length": 1300, "protein_name": "Histone-lysine N-methyltransferase Suv4-20", "gene_name": "Hmt4-20", "organism": "Fruit fly", "refseq_name": "histone methyltransferase 4-20, isoform B", "refseq_ac": "NP_001245453", "gene_names_uniprotkb": "Hmt4-20; BcDNA:LD36415; CG13363; Dmel\\CG13363; Dmel_CG13363; EG:115C2.10; SUV4-20; Su(var)4-20; Suv4-20; Suv4.20; dSuv4-20; hmt4-20", "gene_names_refseq": "BcDNA:LD36415; CG13363; Dmel\\CG13363; EG:115C2.10; Hmt4-20; SUV4-20; Su(var)4-20; Suv4-20; Suv4.20; dSuv4-20; hmt4-20", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase Suv4-20; 2.1.1.361; 2.1.1.362; Su(var)4-20; Suppressor of variegation 4-20", "protein_names_refseq": "CG13363-PB; Hmt4-20-PB; Suv4-20; histone methyltransferase 4-20, isoform B; histone methyltransferase 4-20", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 51 (Disease Ontology:DOID:0080232); liver benign neoplasm (Disease Ontology:DOID:916)", "pathway": " (dme:Dmel_CG13363); (R-DME-3214841)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;15145825;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Acts as a dominant suppressor of position-effect variegation., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O77261;Q8T029;Q8T3U6", "ec_number_list": "2.1.1.361;2.1.1.362", "go_molecular_function": "GO:0042799 histone H4K20 methyltransferase activity;GO:0140941 histone H4K20me methyltransferase activity;GO:0140944 histone H4K20 monomethyltransferase activity;GO:0140943 histone H4K20 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000792 heterochromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0040029 epigenetic regulation of gene expression;GO:0031507 heterochromatin formation;GO:0140719 constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9W5E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VT65-1", "uniprot_id": "CANB_DROME", "mass": 103814.0, "length": 925, "protein_name": "Calpain-B", "gene_name": "CalpB", "organism": "Fruit fly", "refseq_name": "Calpain-B, isoform B", "refseq_ac": "NP_001246706", "gene_names_uniprotkb": "CalpB; CALPB; CG8107; Calp B; Dmel\\CG8107; Dmel_CG8107; calpB", "gene_names_refseq": "CALPB; CG8107; Calp B; CalpB; Dmel\\CG8107; calpB", "protein_names_uniprotkb": "Calpain-B; 3.4.22.-; CANP B; Calcium-activated neutral proteinase B", "protein_names_refseq": "CG8107-PB; CalpB-PB; Calpain-B, isoform B; calpain B; calpainB", "tax_id": 7227, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); autosomal dominant limb-girdle muscular dystrophy (Disease Ontology:DOID:0110273); autosomal recessive limb-girdle muscular dystrophy type 2A (Disease Ontology:DOID:0110275); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); epilepsy (Disease Ontology:DOID:1826); hereditary spastic paraplegia (Disease Ontology:DOID:2476); acute kidney failure (Disease Ontology:DOID:3021); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dme:Dmel_CG8107); (R-DME-6798695)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10446155;10731132;12537568;12537572;12537573;12537574;14614768;16110336;17569856;17569867;19694808;25589440;26109356;26109357", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A9UN95;O96454", "ec_number_list": "2.4.1.186;5.4.2.7;5.4.2.-;3.2.1.31;1.1.1.42;2.4.2.1;2.7.11.24;2.7.1.40;4.1.2.13;2.7.4.6;3.6.5.-;1.11.1.6;5.3.1.9;2.7.1.11;1.1.1.205;3.4.22.-;3.6.4.12;3.6.4.6;1.16.3.1;2.3.2.5;3.4.24.-;2.3.2.27;2.7.1.1;5.2.1.8;3.4.19.-;1.11.1.24;5.6.1.5;5.4.2.11;5.4.2.4;3.2.1.23;3.6.1.5;3.6.4.13;3.3.2.6;3.5.4.5;2.7.11.22;2.7.11.23;4.2.1.24;5.4.2.2;3.4.-.-;2.4.1.25;3.2.1.33;2.7.1.-;3.5.4.6;2.3.2.26", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016322 neuron remodeling;GO:0016540 protein autoprocessing;GO:0007298 border follicle cell migration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VT65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VY99-1", "uniprot_id": "NNAD_DROME", "mass": 133999.0, "length": 1201, "protein_name": "Cytosolic carboxypeptidase Nna1", "gene_name": "Nna1", "organism": "Fruit fly", "refseq_name": "Nna1 carboxypeptidase, isoform D", "refseq_ac": "NP_001096975", "gene_names_uniprotkb": "Nna1; CG11428; CG32627; CG32628; CG44533; Dmel\\CG44533; Dmel_CG44533; NnaD; Nnad", "gene_names_refseq": "CG11428; CG32627; CG32628; CG44533; Dmel\\CG44533; Nna1; NnaD; Nnad", "protein_names_uniprotkb": "Cytosolic carboxypeptidase Nna1; 3.4.17.-; Nervous system nuclear protein induced by axotomy protein 1 homolog", "protein_names_refseq": "CG44533-PD; Nna1 carboxypeptidase, isoform D; Nna1-PD; drosophila Nna1 ortholog", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG44533)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;20620870;25589440;26109356;26109357", "class_list": "", "function": "Metallocarboxypeptidase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JUW0;C7LAD7;Q86B56;Q8T9D7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0015630 microtubule cytoskeleton;GO:0005814 centriole", "go_biological_process": "GO:0006508 proteolysis;GO:0007005 mitochondrion organization;GO:0002164 larval development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VY99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWG3-1", "uniprot_id": "RS10B_DROME", "mass": 17878.0, "length": 160, "protein_name": "Small ribosomal subunit protein eS10B", "gene_name": "RpS10b", "organism": "Fruit fly", "refseq_name": "ribosomal protein S10b, isoform D", "refseq_ac": "NP_001245758", "gene_names_uniprotkb": "RpS10b; CG14206; CT33819; Dmel\\CG14206; Dmel_CG14206; GM19176; M(1)18C; M(1)36f; M(1)n; M[[n]]; Rp S10 b; RpS10; S10b; i3; i73; l(1)G0493; l(1)carot13", "gene_names_refseq": "CG14206; CT33819; Dmel\\CG14206; GM19176; M(1)18C; M(1)36f; M(1)n; M[[n]]; Rp S10 b; RpS10b; S10b; i3; i73; l(1)G0493; l(1)carot13", "protein_names_uniprotkb": "Small ribosomal subunit protein eS10B; 40S ribosomal protein S10b", "protein_names_refseq": "CG14206-PD; Minute-n; RpS10b-PD; lethal (1) G0493; minute (1) 18C; ribosomal protein S10b, isoform D", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 9 (Disease Ontology:DOID:0111884)", "pathway": " (dme:Dmel_CG14206); (R-DME-156827); (R-DME-1799339); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4S6;Q8SZG7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit;GO:0005737 cytoplasm;GO:0005840 ribosome", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VWG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSH4-1", "uniprot_id": "CPSF6_DROME", "mass": 71094.0, "length": 652, "protein_name": "Cleavage and polyadenylation specificity factor subunit 6", "gene_name": "Cpsf6", "organism": "Fruit fly", "refseq_name": "cleavage and polyadenylation specific factor 6, isoform A", "refseq_ac": "NP_648206", "gene_names_uniprotkb": "Cpsf6; CF I[[m]]68; CFI68; CFIm68; CFlm-68k; CG7185; CPSF6; Dmel\\CG7185; Dmel_CG7185; cg7185; dCPSF6", "gene_names_refseq": "CF I[[m]]68; CFI68; CFIm68; CFlm-68k; CG7185; CPSF6; Cpsf6; Dmel\\CG7185; cg7185; dCPSF6", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 6", "protein_names_refseq": "CG7185-PA; Cpsf6-PA; cleavage and polyadenylation specific factor 6, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7185); (R-DME-73856); (R-DME-77595); (R-DME-9013422); (R-DME-9770562)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May play a role in pre-mRNA 3'-processing., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95TS9", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0110104 mRNA alternative polyadenylation;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VSH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWB9-1", "uniprot_id": "THADA_DROME", "mass": 197353.0, "length": 1746, "protein_name": "tRNA (32-2'-O)-methyltransferase regulator THADA", "gene_name": "THADA", "organism": "Fruit fly", "refseq_name": "THADA, isoform B", "refseq_ac": "NP_608361", "gene_names_uniprotkb": "THADA; CG15618; Dmel\\CG15618; Dmel_CG15618", "gene_names_refseq": "CG15618; Dmel\\CG15618; THADA", "protein_names_uniprotkb": "tRNA (32-2'-O)-methyltransferase regulator THADA; Thyroid adenoma-associated protein homolog", "protein_names_refseq": "CG15618-PB; THADA, isoform B; THADA-PB", "tax_id": 7227, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG15618)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;28399403;31943105", "class_list": "", "function": "Together with methyltransferase Trm7-32, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs (By similarity). Plays a key role in energy homeostasis by regulating the balance between energy storage and heat production. Functions by negatively regulating Ca(2+) signaling pathways that are involved in heat production and maintaining correct lipid storage in the fat body. Regulates Ca(2+) signaling pathways by reducing the activity of the calcium-transporting ATPase SERCA possibly by promoting uncoupling of SERCA ATP hydrolysis from calcium pumping. May also function in the nervous system to control feeding behavior (PubMed:28399403)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQL6", "ec_number_list": "", "go_molecular_function": "GO:0019855 calcium channel inhibitor activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane", "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0010888 negative regulation of lipid storage;GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration;GO:1990845 adaptive thermogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VWB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VV43-1", "uniprot_id": "TPPP_DROME", "mass": 20596.0, "length": 192, "protein_name": "Tubulin polymerization-promoting protein homolog", "gene_name": "ringer", "organism": "Fruit fly", "refseq_name": "ringmaker, isoform B", "refseq_ac": "NP_001246792", "gene_names_uniprotkb": "ringer; CG34249; CG45027; CG45057; CG4893; Dmel\\CG45057; Dmel_CG45057; HDC10482; TPPP; mdcds_27436", "gene_names_refseq": "CG34249; CG45027; CG45057; CG4893; Dmel\\CG45057; HDC10482; TPPP; mdcds_27436; ringer", "protein_names_uniprotkb": "Tubulin polymerization-promoting protein homolog; Protein ringmaker; TPPP", "protein_names_refseq": "CG45057-PB; long-type TPPP; ringer-PB; ringmaker, isoform B; tubulin polymerization promoting protein", "tax_id": 7227, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dme:Dmel_CG45057)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;27422099;31156389;31919191", "class_list": "", "function": "Regulator of microtubules required for axonal extension during embryonic development and axon regeneration following injury (PubMed:27422099, PubMed:31919191). Promotes microtubule bundling and polymerization (PubMed:27422099). Together with futsch, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules (PubMed:31156389). Function with futsch in maintaining microtubule stability and dynamics, is essential for promoting axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury (PubMed:31919191). In response to axotomy, acts downstream of a stress response cascade involving Xbp1 splicing, to control axon regeneration (PubMed:31919191)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body;GO:0098793 presynapse", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0046785 microtubule polymerization;GO:0000226 microtubule cytoskeleton organization;GO:0001578 microtubule bundle formation;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VV43-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W596-1", "uniprot_id": "FUTSC_DROME", "mass": 592078.0, "length": 5495, "protein_name": "Microtubule-associated protein futsch", "gene_name": "futsch", "organism": "Fruit fly", "refseq_name": "futsch, isoform C", "refseq_ac": "NP_001096864", "gene_names_uniprotkb": "futsch; 22C10; 22C20; 22c10; CG14772; CG3064; CG34387; Dmel\\CG34387; Dmel_CG34387; EG:49E4.1; FUTSCH; Futch; Futsch; MAP-1b; MAP-IB; MAP1B; MAb22C10; Mab 22C10; Mab22C10; Mab22c10; Map-1B; Map1B; Olk; lincRNA.936; mAb 22C10; mAb-22C10; mAb22C10; mAb22c10; map1b; olk; ssC10", "gene_names_refseq": "22C10/FUTSCH; 22C10; 22C20; 22c10; CG14772; CG3064; CG34387; Dmel\\CG34387; EG:49E4.1; FUTSCH; Futch; Futsch; MAP-1b; MAP-IB; MAP1B; MAb22C10; Mab 22C10; Mab22C10; Mab22c10; Map-1B; Map1B; Olk; futsch; lincRNA.936; mAb 22C10; mAb-22C10; mAb22C10; mAb22c10; map1b; olk; ssC10", "protein_names_uniprotkb": "Microtubule-associated protein futsch; MAP1B homolog", "protein_names_refseq": "CG34387-PC; MAP1B-like; MAP1B; futch; futsch, isoform C; futsch-PC; omb-like", "tax_id": 7227, "disease": "periventricular nodular heterotopia (Disease Ontology:DOID:0050454); autosomal dominant nonsyndromic deafness 83 (Disease Ontology:DOID:0070609); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (dme:Dmel_CG34387)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10731132;10731137;10839355;10839356;11733059;12537568;12537572;12537573;12537574;16110336;16949836;17372656;17569856;17569867;18419581;21159966;25589440;26109356;26109357;31156389;31919191;33925313;40245499", "class_list": "", "function": "During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton (PubMed:10839355, PubMed:10839356, PubMed:11733059). Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by futsch (PubMed:10839355, PubMed:10839356, PubMed:11733059). Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching (PubMed:10839355, PubMed:10839356, PubMed:11733059). Translation is repressed by Fmr1 (PubMed:10839355, PubMed:10839356, PubMed:11733059). Together with ringer, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules (PubMed:31156389). Function with ringer in maintaining microtubule stability and dynamics, is essential for promoting axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury (PubMed:31919191). In response to axotomy, acts downstream of a stress response cascade involving Xbp1 splicing, to control axon regeneration (PubMed:31919191)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 19, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 19, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 19, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "A8JTS2;B2YGG3;O76891", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0007409 axonogenesis;GO:0008088 axo-dendritic transport;GO:0016358 dendrite development;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q9W596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWD6-1", "uniprot_id": "OSGP2_DROME", "mass": 45329.0, "length": 409, "protein_name": "Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial", "gene_name": "Tcs4", "organism": "Fruit fly", "refseq_name": "Threonyl-carbamoyl synthesis 4, isoform B", "refseq_ac": "NP_001245765", "gene_names_uniprotkb": "Tcs4; CG14231; Dmel\\CG14231; Dmel_CG14231", "gene_names_refseq": "CG14231; Dmel\\CG14231; Tcs4", "protein_names_uniprotkb": "Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; Threonyl-carbamoyl synthesis 4; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Tcs4; tRNA threonylcarbamoyladenosine biosynthesis protein Tcs4", "protein_names_refseq": "CG14231-PB; Tcs4-PB; Threonyl-carbamoyl synthesis 4, isoform B; tRNA adenosine(37) threonylcarbamoyltransferase, mitochondrial", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14231)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q960S6", "ec_number_list": "2.3.1.234", "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0072670 mitochondrial tRNA threonylcarbamoyladenosine modification;GO:0002949 tRNA threonylcarbamoyladenosine modification", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VWD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0V7-1", "uniprot_id": "MTH8_DROME", "mass": 56330.0, "length": 492, "protein_name": "Probable G protein-coupled receptor Mth-like 8", "gene_name": "mthl8", "organism": "Fruit fly", "refseq_name": "methuselah-like 8, isoform B", "refseq_ac": "NP_001261182", "gene_names_uniprotkb": "mthl8; CG11869; CG13406; CG32475; Dmel\\CG32475; Dmel_CG32475; Mth-8; Mthl8; anon-WO0170980.145; anon-WO0170980.146; mthl-8", "gene_names_refseq": "CG11869; CG13406; CG32475; Dmel\\CG32475; Mth-8; Mthl8; anon-WO0170980.145; anon-WO0170980.146; mthl-8; mthl8", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 8; Protein methuselah-like 8", "protein_names_refseq": "CG32475-PB; Methuselah-like 8; methuselah-like 8, isoform B; mth-like 8; mthl8-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32475)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10908591;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0V8", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W0V7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0E8-1", "uniprot_id": "ZER1_DROME", "mass": 90366.0, "length": 793, "protein_name": "Protein zer-1 homolog", "gene_name": "LD02105", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": "NP_612112", "gene_names_uniprotkb": "LD02105; BEST:LD02105; CG12084; Dmel\\CG12084; Dmel_CG12084", "gene_names_refseq": "BEST:LD02105; CG12084; Dmel\\CG12084; LD02105", "protein_names_uniprotkb": "Protein zer-1 homolog; Zyg-11 homolog B-like protein", "protein_names_refseq": "CG12084-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12084)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17304241;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Serves as substrate adapter subunit in an E3 ubiquitin ligase complex CG12084-cul-2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W0E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSF3-1", "uniprot_id": "UBC2M_DROME", "mass": 20738.0, "length": 181, "protein_name": "Nedd8-conjugating enzyme UbcE2M", "gene_name": "UbcE2M", "organism": "Fruit fly", "refseq_name": "NEDD8-conjugating enzyme UbcE2M, isoform B", "refseq_ac": "NP_001261567", "gene_names_uniprotkb": "UbcE2M; CG7375; Dmel\\CG7375; Dmel_CG7375; UBC12; Ubc12; UbcD12; anon-WO0118547.309; dUbc12; ubcD12", "gene_names_refseq": "CG7375; Dmel\\CG7375; UBC12; Ubc12; UbcD12; UbcE2M; anon-WO0118547.309; dUbc12; ubcD12", "protein_names_uniprotkb": "Nedd8-conjugating enzyme UbcE2M; 2.3.2.34; Nedd8 carrier protein", "protein_names_refseq": "CG7375-PB; NEDD8-conjugating enzyme UbcE2M, isoform B; UbcE2M-PB; ubiquitin conjugating enzyme 12; ubiquitin conjugating enzyme E2M", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7375); (R-DME-2173789); (R-DME-8951664); (R-DME-983168)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;21931660;25589440;26109356;26109357", "class_list": "", "function": "Accepts the ubiquitin-like protein Nedd8 from the Uba3-APP-BP1 E1 complex and catalyzes its covalent attachment to other proteins. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;2.7.11.30;2.3.2.25;2.3.2.23;2.3.2.31;6.2.1.64;2.3.2.26;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0061654 NEDD8 conjugating enzyme activity;GO:0005524 ATP binding;GO:0019788 NEDD8 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0036211 protein modification process;GO:0045116 protein neddylation;GO:0045879 negative regulation of smoothened signaling pathway;GO:0061059 positive regulation of peptidoglycan recognition protein signaling pathway;GO:0140958 target-directed miRNA degradation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VSF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMU5-1", "uniprot_id": "QTC_DROME", "mass": 80087.0, "length": 721, "protein_name": "Protein quick-to-court", "gene_name": "qtc", "organism": "Fruit fly", "refseq_name": "quick-to-court, isoform F", "refseq_ac": "NP_001014469", "gene_names_uniprotkb": "qtc; CG14039; Dmel\\CG14039; Dmel_CG14039", "gene_names_refseq": "CG14039; Dmel\\CG14039; qtc", "protein_names_uniprotkb": "Protein quick-to-court", "protein_names_refseq": "CG14039-PF; Quick-to-court; qtc-PF; quick-to-court, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14039)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10747058;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22292044;25589440;26109356;26109357", "class_list": "", "function": "In adult males, modulates sexual behavior by playing a role in sex discrimination and maintaining normal levels of sexual activity towards both males and females., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C8VV94;C9QPB9;E6PBY5;M9MRI9;Q8I0H9;Q95TG9;R4TUN8;R9TC66;X2J8M5;X2J9D4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0008049 male courtship behavior;GO:0048047 mating behavior, sex discrimination;GO:0007619 courtship behavior", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VMU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VML9-1", "uniprot_id": "TRISR_DROME", "mass": 74486.0, "length": 669, "protein_name": "Trissin receptor", "gene_name": "TrissinR", "organism": "Fruit fly", "refseq_name": "trissin receptor, isoform B", "refseq_ac": "NP_001097092", "gene_names_uniprotkb": "TrissinR; CG14002; CG14003; CG14004; CG31645; CG34381; Dmel\\CG34381; Dmel_CG34381; Trissin-R; anon-WO0170980.172; anon-WO0170980.173", "gene_names_refseq": "CG14002; CG14003; CG14004; CG31645; CG34381; Dmel\\CG34381; Trissin-R; TrissinR; anon-WO0170980.172; anon-WO0170980.173", "protein_names_uniprotkb": "Trissin receptor", "protein_names_refseq": "CG34381-PB; TrissinR-PB; trissin receptor, isoform B; trissin receptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34381)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;21939639;25589440;26109356;26109357", "class_list": "", "function": "G protein-coupled receptor which is activated by the Trissin peptide in vitro, leading to increased intracellular calcium ion levels., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9VMM1", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VML9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMA0-1", "uniprot_id": "NSE1_DROME", "mass": 26774.0, "length": 235, "protein_name": "Non-structural maintenance of chromosomes element 1 homolog", "gene_name": "Nse1", "organism": "Fruit fly", "refseq_name": "Non-SMC element 1, isoform B", "refseq_ac": "NP_001260145", "gene_names_uniprotkb": "Nse1; CG11329; Dmel\\CG11329; Dmel_CG11329; EST2; GM14348; NSE1; anon-WO0118547.82", "gene_names_refseq": "CG11329; Dmel\\CG11329; EST2; GM14348; NSE1; Nse1; anon-WO0118547.82", "protein_names_uniprotkb": "Non-structural maintenance of chromosomes element 1 homolog; 2.3.2.27; Non-SMC element 1 homolog", "protein_names_refseq": "CG11329-PB; Non-SMC element 1, isoform B; Nse1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11329)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;23555814;25589440;26109356;26109357", "class_list": "", "function": "Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:23555814). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0000724 double-strand break repair via homologous recombination;GO:0140588 chromatin looping", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VMA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VQH2-1", "uniprot_id": "DUOX_DROME", "mass": 177690.0, "length": 1537, "protein_name": "Dual oxidase", "gene_name": "Duox", "organism": "Fruit fly", "refseq_name": "dual oxidase, isoform C", "refseq_ac": "NP_001259968", "gene_names_uniprotkb": "Duox; CG3131; Cy; DUOX; Dmel\\CG3131; Dmel_CG3131; DuoX; dDuox; dduox; duOx; duox; l(2)23Bb", "gene_names_refseq": "CG3131; Cy; DUOX; Dmel\\CG3131; DuoX; Duox; dDuox; dduox; duOx; duox; l(2)23Bb", "protein_names_uniprotkb": "Dual oxidase; 1.11.1.-; 1.6.3.1", "protein_names_refseq": "CG3131-PC; Duox-PC; NADPH dual oxidase; curly; dual oxidase, isoform C", "tax_id": 7227, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); primary bacterial infectious disease (Disease Ontology:DOID:0050338); thyroid dyshormonogenesis 6 (Disease Ontology:DOID:0112189); hypothyroidism (Disease Ontology:DOID:1459); cholera (Disease Ontology:DOID:1498); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (dme:Dmel_CG3131); (R-DME-209968)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16272120;17372656;17569856;17569867;18327897;25589440;25639794;26109356;26109357", "class_list": "", "function": "Plays a role in innate immunity limiting microbial proliferation in the gut (PubMed:16272120, PubMed:25639794). Acts downstream of a hh-signaling pathway to induce the production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). May generate antimicrobial oxidative burst through its peroxidase-like domain (PubMed:16272120)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWK1", "ec_number_list": "1.6.99.1;1.11.1.-;1.6.3.1;1.11.2.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004601 peroxidase activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0016020 membrane", "go_biological_process": "GO:0042335 cuticle development;GO:0006952 defense response;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VQH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKX4-1", "uniprot_id": "RT07_DROME", "mass": 25140.0, "length": 218, "protein_name": "Small ribosomal subunit protein uS7m", "gene_name": "mRpS7", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein S7, isoform B", "refseq_ac": "NP_001260339", "gene_names_uniprotkb": "mRpS7; CG5108; Dmel\\CG5108; Dmel_CG5108; MRP-S7; RpS7; mRPS7", "gene_names_refseq": "CG5108; Dmel\\CG5108; MRP-S7; RpS7; mRPS7; mRpS7", "protein_names_uniprotkb": "Small ribosomal subunit protein uS7m; 28S ribosomal protein S7, mitochondrial; MRP-S7; S7mt", "protein_names_refseq": "CG5108-PB; mRpS7-PB; mitochondrial ribosomal protein S7, isoform B", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 34 (Disease Ontology:DOID:0111497)", "pathway": " (dme:Dmel_CG5108); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VKX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XTN2-1", "uniprot_id": "IRS1_DROME", "mass": 107832.0, "length": 968, "protein_name": "Insulin receptor substrate 1", "gene_name": "chico", "organism": "Fruit fly", "refseq_name": "chico, isoform B", "refseq_ac": "NP_001188772", "gene_names_uniprotkb": "chico; BcDNA.GH11263; BcDNA:GH11263; CG5686; CHICO; Chico; Dmel\\CG5686; Dmel_CG5686; IRS; anon-WO0078940.1; anon-WO0078940.4; chico; chic; dIRS; fs(2)4; fs(2)ry4", "gene_names_refseq": "BcDNA.GH11263; BcDNA:GH11263; CG5686; CHICO; Chico/IRS; Chico; Dmel\\CG5686; IRS/chico; IRS; anon-WO0078940.1; anon-WO0078940.4; chico; chic; dIRS; fs(2)4; fs(2)ry4", "protein_names_uniprotkb": "Insulin receptor substrate 1; Protein chico; dIRS", "protein_names_refseq": "CG5686-PB; chico, isoform B; chico-PB; flipper; insulin receptor substrate; insulin-like receptor substrate", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital nongoitrous hypothyroidism 9 (Disease Ontology:DOID:0111835); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); amnestic disorder (Disease Ontology:DOID:10914); osteoporosis (Disease Ontology:DOID:11476); uterine fibroid (Disease Ontology:DOID:13223); lung cancer (Disease Ontology:DOID:1324); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); glucose metabolism disease (Disease Ontology:DOID:4194); end stage renal disease (Disease Ontology:DOID:783); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG5686); (R-DME-109704); (R-DME-110478); (R-DME-112399); (R-DME-112412); (R-DME-1257604); (R-DME-5673001); (R-DME-6811558); (R-DME-74749)", "pathway_count": 9, "publication_count": 27, "publication_id_list": "10399915;10455177;10731132;10731138;10801879;11250149;11292874;11752451;11872800;12537568;12537572;12537573;12537574;12893776;15890189;16110336;17569856;17569867;18327897;20074316;25589440;26109356;26109357;7628438;8978685;9169420;9368760", "class_list": "", "function": "Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D0UY43;D0UY45;D0UY46;D0UY47;D0UY49;D0UY50;D0UY51;D0UY52;D0UY54;D0UY55;D0UY61;D0UY62;D0UY64;D0UY65;D0UY66;D0UY67;D0UY68;Q5U0V5;Q9U4G2", "ec_number_list": "", "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005159 insulin-like growth factor receptor binding;GO:0042169 SH2 domain binding;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007296 vitellogenesis;GO:0048133 male germ-line stem cell asymmetric division;GO:0008284 positive regulation of cell population proliferation;GO:0042594 response to starvation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9XTN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VUY8-1", "uniprot_id": "WASC5_DROME", "mass": 137274.0, "length": 1191, "protein_name": "WASH complex subunit homolog 5", "gene_name": "Strump", "organism": "Fruit fly", "refseq_name": "strumpellin, isoform B", "refseq_ac": "NP_001163454", "gene_names_uniprotkb": "Strump; CG12272; Dmel\\CG12272; Dmel_CG12272; p118; strump", "gene_names_refseq": "CG12272; Dmel\\CG12272; Strump; p118; strump", "protein_names_uniprotkb": "WASH complex subunit homolog 5; WASH complex subunit strumpellin homolog", "protein_names_refseq": "CG12272-PB; Strump-PB; strumpellin, isoform B", "tax_id": 7227, "disease": "Ritscher-Schinzel syndrome 1 (Disease Ontology:DOID:0060571); hereditary spastic paraplegia 8 (Disease Ontology:DOID:0110823)", "pathway": " (dme:Dmel_CG12272)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;20498093;25589440;25739458;26109356;26109357", "class_list": "", "function": "Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail (PubMed:25739458)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AVW2;D3DMJ6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0031901 early endosome membrane;GO:0071203 WASH complex", "go_biological_process": "GO:0051125 regulation of actin nucleation;GO:0015031 protein transport;GO:0045785 positive regulation of cell adhesion;GO:0007032 endosome organization;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VUY8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVI9-1", "uniprot_id": "CHMP5_DROME", "mass": 25151.0, "length": 226, "protein_name": "Charged multivesicular body protein 5", "gene_name": "Vps60", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 60, isoform B", "refseq_ac": "NP_001261994", "gene_names_uniprotkb": "Vps60; CG6259; Chmp5; Dchmp5; Dmel\\CG6259; Dmel_CG6259; VPS60; anon-74EFb; bs36h07.y1", "gene_names_refseq": "CG6259; Chmp5; Dchmp5; Dmel\\CG6259; VPS60; Vps60; anon-74EFb; bs36h07.y1", "protein_names_uniprotkb": "Charged multivesicular body protein 5; Vacuolar protein-sorting-associated protein 60", "protein_names_refseq": "CG6259-PB; Vps60-PB; vacuolar protein sorting 60, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6259)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15952742;16110336;17372656;17569856;17569867;18327897;24762813;25589440;26109356;26109357", "class_list": "", "function": "Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity). Specifically down-regulates Notch signaling activity in the germarium, probably by facilitating Notch endocytosis (PubMed:24762813)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0005771 multivesicular body", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0046718 symbiont entry into host cell;GO:0006900 vesicle budding from membrane", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VVI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VK07-1", "uniprot_id": "UVRAG_DROME", "mass": 80690.0, "length": 696, "protein_name": "UV radiation resistance-associated gene protein", "gene_name": "Uvrag", "organism": "Fruit fly", "refseq_name": "UV-resistance associated gene, isoform A", "refseq_ac": "NP_609632", "gene_names_uniprotkb": "Uvrag; CG6116; Dmel\\CG6116; Dmel_CG6116; UVRAG; Vps38; dUVRAG; uvrag", "gene_names_refseq": "CG6116; Dmel\\CG6116; UVRAG; Uvrag; Vps38; dUVRAG; uvrag", "protein_names_uniprotkb": "UV radiation resistance-associated gene protein; UV-resistance associated gene", "protein_names_refseq": "CG6116-PA; UV radiation resistance associated gene; UV-resistance associated gene, isoform A; Uvrag-PA; ultraviolet (UV) radiation resistance-associated gene", "tax_id": 7227, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG6116); (R-DME-1632852)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;21729695;24554766;25589440;26109356;26109357", "class_list": "", "function": "Involved in biosynthetic vesicle transport to lysosomes (PubMed:24554766). Acts as a cell growth regulator (PubMed:21729695). Also has a crucial role in controlling organ rotation by regulating membrane-localized Notch receptor endocytosis and subsequent degradation (PubMed:21729695). Regulation of organ rotation is not by induction of autophagy (PubMed:21729695)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0005768 endosome;GO:0000323 lytic vacuole", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0016322 neuron remodeling;GO:0006909 phagocytosis;GO:0006622 protein targeting to lysosome", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VK07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V412-1", "uniprot_id": "STEEP_DROME", "mass": 27696.0, "length": 247, "protein_name": "STING ER exit protein", "gene_name": "BG:DS00941.3; Steep1", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001260451", "gene_names_uniprotkb": "BG:DS00941.3; Steep1; CG16865; Dmel\\CG16865; Dmel_CG16865", "gene_names_refseq": "BG:DS00941.3; CG16865; Dmel\\CG16865", "protein_names_uniprotkb": "STING ER exit protein; STEEP", "protein_names_refseq": "CG16865-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "non-syndromic X-linked intellectual disability 107 (Disease Ontology:DOID:0112054)", "pathway": " (dme:Dmel_CG16865); (R-DME-72163)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Molecular adapter that stimulates membrane curvature formation and subsequent endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K complex I, leading to COPII vesicle-mediated transport (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9V412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VP76-1", "uniprot_id": "AC78C_DROME", "mass": 189013.0, "length": 1718, "protein_name": "Adenylyl cyclase 78C", "gene_name": "Ac78C", "organism": "Fruit fly", "refseq_name": "adenylyl cyclase 78C, isoform C", "refseq_ac": "NP_001246857", "gene_names_uniprotkb": "Ac78C; AC 78C; AC78C; CG10554; CG10564; DAC78C-s; DAC78C; Dmel\\CG10564; Dmel_CG10564; dADCY8", "gene_names_refseq": "AC 78C; AC78C; Ac78C; CG10554; CG10564; DAC78C-s; DAC78C; Dmel\\CG10564; dADCY8", "protein_names_uniprotkb": "Adenylyl cyclase 78C; 4.6.1.1", "protein_names_refseq": "Ac78C-PC; CG10564-PC; adenylyl cyclase 78C, isoform C; adenylyl cyclase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10564); (R-DME-163615); (R-DME-170660); (R-DME-170670); (R-DME-418597); (R-DME-5610787)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10603085;10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;19046378;23929551;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein-coupled receptor signaling (PubMed:10603085, PubMed:23929551). Probably downstream of gustatory receptors, involved in taste perception of sucrose, trehalose and caffeine (PubMed:19046378). Has no role in bitter perception (PubMed:19046378). In the circadian brain neuron evening cells (E-cells), involved in circadian pacemaker synchronization by playing a role in signaling downstream of the G protein-coupled receptor Pdfr, probably in conjunction with other, as yet unidentified, adenylate cyclases (PubMed:23929551)., [UniProtKB, PubMed, PubMed, PubMed]; Does not have adenylyl cyclase activity and it is not involved in taste perception., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "M9NG95;Q9VP75", "ec_number_list": "4.6.1.1", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste;GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0031000 response to caffeine", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VP76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VK41-1", "uniprot_id": "TTC30_DROME", "mass": 73046.0, "length": 655, "protein_name": "Tetratricopeptide repeat protein 30 homolog", "gene_name": "Ttc30", "organism": "Fruit fly", "refseq_name": "tetratricopeptide repeat domain 30, isoform C", "refseq_ac": "NP_001097155", "gene_names_uniprotkb": "Ttc30; CG5142; Dmel\\CG5142; Dmel_CG5142; TTC30", "gene_names_refseq": "CG5142; Dmel\\CG5142; TTC30; Ttc30", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 30 homolog; TPR repeat protein 30 homolog", "protein_names_refseq": "CG5142-PC; Ttc30-PC; tetratricopeptide repeat domain 30, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5142)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Required for polyglutamylation of axonemal tubulin in sensory cilia. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB, UniProtKB, UniProtKB]; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V562;Q4V594", "ec_number_list": "", "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005929 cilium;GO:0005879 axonemal microtubule;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0018095 protein polyglutamylation;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VK41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3R6-1", "uniprot_id": "ADAT1_DROME", "mass": 45350.0, "length": 394, "protein_name": "tRNA-specific adenosine deaminase 1", "gene_name": "Adat1", "organism": "Fruit fly", "refseq_name": "adenosine deaminase, tRNA-specific 1, isoform B", "refseq_ac": "NP_001260450", "gene_names_uniprotkb": "Adat1; Adat; BG:DS00941.2; CG16889; Dmel\\CG16889; Dmel_CG16889; adat; dADAT1", "gene_names_refseq": "Adat1; Adat; BG:DS00941.2; CG16889; Dmel\\CG16889; adat; dADAT1", "protein_names_uniprotkb": "tRNA-specific adenosine deaminase 1; 3.5.4.34; dADAT1; tRNA-specific adenosine-37 deaminase", "protein_names_refseq": "Adat1-PB; CG16889-PB; adat; adenosine deaminase, tRNA-specific 1, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16889)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10629039;10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Specifically deaminates adenosine-37 to inosine in tRNA-Ala., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.34", "go_molecular_function": "GO:0003723 RNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:0008033 tRNA processing;GO:0006400 tRNA modification;GO:0006382 adenosine to inosine editing", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V3R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VIF5-1", "uniprot_id": "DEL_DROME", "mass": 110817.0, "length": 981, "protein_name": "Protein deadlock", "gene_name": "del", "organism": "Fruit fly", "refseq_name": "deadlock, isoform C", "refseq_ac": "NP_001260666", "gene_names_uniprotkb": "del; CG9252; DEL; Del; Dmel\\CG9252; Dmel_CG9252", "gene_names_refseq": "CG9252; DEL; Del; Dmel\\CG9252; del", "protein_names_uniprotkb": "Protein deadlock", "protein_names_refseq": "CG9252-PC; deadlock, isoform C; deadlock; del-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9252)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16616913;17569856;17569867;24906153;25589440;26109356;26109357;27292797;28847004;29858487", "class_list": "", "function": "Developmental protein involved in oogenesis (PubMed:16616913). Required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females (PubMed:16616913). Also required for dorso-ventral and antero-posterior patterning of oocyte and eggshell (PubMed:16616913). May be involved in microtubule function during oogenesis (PubMed:16616913). Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers (PubMed:28847004). Component of the RDC complex (rhi, del and cuff) which binds to repressive H3K9me3 marks in the piRNA clusters (PubMed:28847004). RDC promotes the bidirectional transcription of piRNA clusters at these sites by interacting with Moonshiner which forms a complex with the transcription initiation factors TfIIA-S and Trf2 (PubMed:28847004). This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark (PubMed:28847004). As part of the RDC complex, involved in suppression of splicing (PubMed:27292797)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86P81", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0000792 heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048477 oogenesis;GO:0007052 mitotic spindle organization;GO:0034587 piRNA processing;GO:0048599 oocyte development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VIF5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0K7-1", "uniprot_id": "BAB1_DROME", "mass": 103324.0, "length": 977, "protein_name": "Protein bric-a-brac 1", "gene_name": "bab1", "organism": "Fruit fly", "refseq_name": "bric a brac 1, isoform B", "refseq_ac": "NP_728565", "gene_names_uniprotkb": "bab1; BAB-1; BAB1; BAB; Bab1; CG13910; CG9097; Dmel\\CG9097; Dmel_CG9097; anon-WO0118547.639; bab-I; bab; bric-a-brac; bric", "gene_names_refseq": "BAB-1; BAB1; BAB; Bab1; CG13910; CG9097; Dmel\\CG9097; anon-WO0118547.639; bab-I; bab1; bab; bric-a-brac; bric", "protein_names_uniprotkb": "Protein bric-a-brac 1", "protein_names_refseq": "Bric-a-brac; CG9097-PB; bab1-PB; bric a brac 1, isoform B; bric a brac 1; bric a brac I; bric a brac1; bric-a-brac 1; bric-a-brac1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9097)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;11973274;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7760839;9380040", "class_list": "", "function": "Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q23968;Q8MR78;Q9U1H7", "ec_number_list": "", "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007548 sex differentiation;GO:0048070 regulation of developmental pigmentation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9W0K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYT8-1", "uniprot_id": "C28C1_DROME", "mass": 57410.0, "length": 505, "protein_name": "Probable cytochrome P450 28c1", "gene_name": "Cyp28c1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 28c1, isoform B", "refseq_ac": "NP_001259464", "gene_names_uniprotkb": "Cyp28c1; 28c1; CG1895; Dmel\\CG1895; Dmel_CG1895", "gene_names_refseq": "28c1; CG1895; Cyp28c1; Dmel\\CG1895", "protein_names_uniprotkb": "Probable cytochrome P450 28c1; 1.14.-.-; CYPXXVIIIC1", "protein_names_refseq": "CG1895-PB; Cyp28c1-PB; cytochrome P450 28c1, isoform B; cytochrome P450", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1895)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1WW98", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VYT8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95T64-1", "uniprot_id": "PGPLA_DROME", "mass": 40821.0, "length": 368, "protein_name": "Peptidoglycan-recognition protein LA", "gene_name": "PGRP-LA", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein LA, isoform G", "refseq_ac": "NP_001261623", "gene_names_uniprotkb": "PGRP-LA; CG18614; CG32042; CG4361; CG4384; Dmel\\CG32042; Dmel_CG32042; PGRP-La; PGRPLA; PGRP; pgrp-la", "gene_names_refseq": "CG18614; CG32042; CG4361; CG4384; Dmel\\CG32042; PGRP-LA; PGRP-La; PGRPLA; PGRP; pgrp-la", "protein_names_uniprotkb": "Peptidoglycan-recognition protein LA", "protein_names_refseq": "CG32042-PG; PGRP-LA-PG; peptidoglycan recognition protein LA, isoform G", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32042); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;11106397;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17893096;25589440;26109356;26109357", "class_list": "", "function": "Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9BLX5;Q9GNK6;Q9GNK7;Q9VSV7;Q9VSV8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q95T64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VX88-1", "uniprot_id": "WAC_DROME", "mass": 89367.0, "length": 834, "protein_name": "WW domain-containing adapter protein with coiled-coil homolog", "gene_name": "wcy", "organism": "Fruit fly", "refseq_name": "wacky, isoform D", "refseq_ac": "NP_001245725", "gene_names_uniprotkb": "wcy; BP1032; CG34014; CG8949; Dmel\\CG8949; Dmel_CG8949; XE14", "gene_names_refseq": "BP1032; CG34014; CG8949; Dmel\\CG8949; XE14; wcy", "protein_names_uniprotkb": "WW domain-containing adapter protein with coiled-coil homolog; Protein wacky", "protein_names_refseq": "CG8949-PD; wacky, isoform D; wcy-PD", "tax_id": 7227, "disease": "DeSanto-Shinawi syndrome (Disease Ontology:DOID:0081126)", "pathway": " (dme:Dmel_CG8949); (R-DME-8866654)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;11827461;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26757981;26812014", "class_list": "", "function": "Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-118' (By similarity). Regulates the cell-cycle checkpoint activation in response to DNA damage (By similarity). Positive regulator of amino acid starvation-induced autophagy (PubMed:26812014). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates mTor activity (PubMed:26812014). Promotes, in an energy-dependent manner, the assembly of the TTT complex and the RUVBL complex composed of pont and rept into the TTT-RUVBL complex (By similarity). This leads to dimerization of the mTORC1 complex and its subsequent activation (By similarity). May negatively regulate the ubiquitin proteasome pathway (By similarity). Required for habituation, a form of non-associative learning (PubMed:26757981)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q32KD5", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005764 lysosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0046959 habituation;GO:0010506 regulation of autophagy;GO:0006914 autophagy;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VX88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VTE5-1", "uniprot_id": "PFD2_DROME", "mass": 16203.0, "length": 143, "protein_name": "Probable prefoldin subunit 2", "gene_name": "Pfdn2", "organism": "Fruit fly", "refseq_name": "prefoldin 2, isoform B", "refseq_ac": "NP_001261696", "gene_names_uniprotkb": "Pfdn2; CG6302; Dmel\\CG6302; Dmel_CG6302; P01239; l(3)01239; l(3)j9B4; pfdn2", "gene_names_refseq": "CG6302; Dmel\\CG6302; P01239; Pfdn2; l(3)01239; l(3)j9B4; pfdn2", "protein_names_uniprotkb": "Probable prefoldin subunit 2", "protein_names_refseq": "CG6302-PB; Pfdn2-PB; lethal (3) 01239; prefoldin 2, isoform B; prefoldin beta-like subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6302)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C6SV13", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:0045196 establishment or maintenance of neuroblast polarity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VTE5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VUW9-1", "uniprot_id": "HIP14_DROME", "mass": 71299.0, "length": 637, "protein_name": "Palmitoyltransferase Hip14", "gene_name": "Hip14", "organism": "Fruit fly", "refseq_name": "Huntingtin-interacting protein 14, isoform C", "refseq_ac": "NP_001261911", "gene_names_uniprotkb": "Hip14; 3L1; CG 6017; CG6017; Dmel\\CG6017; Dmel_CG6017; HIP14; dHIP14; dHip14; hip14; l(3)72Ad", "gene_names_refseq": "3L1; CG 6017; CG6017; Dmel\\CG6017; HIP14; Hip14; dHIP14; dHip14; hip14; l(3)72Ad", "protein_names_uniprotkb": "Palmitoyltransferase Hip14; 2.3.1.225; Huntingtin-interacting protein 14 homolog", "protein_names_refseq": "CG6017-PC; Hip14-PC; Huntingtin-interacting protein 14, isoform C; ankyrin domain; htt-interacting protein 14; lethal (3) 72Ad", "tax_id": 7227, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (dme:Dmel_CG6017)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18032660;18158335;18719403;20599894;25589440;26109356;26109357", "class_list": "", "function": "Probable palmitoyltransferase which is required for photoreceptor synaptic transmission and for the correct expression and localization of palmitoylated protein Csp and synaptosomal-associated protein Snap25 (PubMed:18032660, PubMed:18158335). Probably palmitoylates Csp (PubMed:18158335). Probably also palmitoylates the dorsal-ventral patterning protein Sog and promotes its secretion and activity and the stabilization of the membrane-bound form (PubMed:20599894). Required for synaptic vesicle exocytosis (PubMed:18158335)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.225", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0008021 synaptic vesicle;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007268 chemical synaptic transmission;GO:0050714 positive regulation of protein secretion;GO:0016079 synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VUW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VV96-1", "uniprot_id": "PGSB2_DROME", "mass": 20459.0, "length": 182, "protein_name": "Peptidoglycan-recognition protein SB2", "gene_name": "PGRP-SB2", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein SB2, isoform A", "refseq_ac": "NP_648916", "gene_names_uniprotkb": "PGRP-SB2; CG9697; Dmel\\CG9697; Dmel_CG9697; PGRP-SB", "gene_names_refseq": "CG9697; Dmel\\CG9697; PGRP-SB2; PGRP-SB", "protein_names_uniprotkb": "Peptidoglycan-recognition protein SB2; 3.5.1.28", "protein_names_refseq": "CG9697-PA; PGRP-SB2-PA; peptidoglycan recognition protein SB2, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9697); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;11106397;12537568;12537572;12537573;12537574;14738318;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q70PX1;Q70PX3;Q70PX5", "ec_number_list": "3.2.1.17;1.1.1.42;3.5.1.28;3.2.1.14;3.5.3.1;4.1.2.13;3.1.3.48;1.16.3.1;2.7.1.35;2.3.2.5;3.4.19.9;3.4.24.-;2.7.10.2;3.6.1.5;3.5.1.3;3.3.2.6;3.5.4.5;5.4.2.2;3.4.17.13;3.2.1.-", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0009253 peptidoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VV96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJN5-1", "uniprot_id": "WEK_DROME", "mass": 53210.0, "length": 470, "protein_name": "Zinc finger protein weckle", "gene_name": "wek", "organism": "Fruit fly", "refseq_name": "weckle, isoform B", "refseq_ac": "NP_001260472", "gene_names_uniprotkb": "wek; BG:DS09217.5; CG4148; Dmel\\CG4148; Dmel_CG4148; WECKLE; Wek; l(2)35Ea; l(2)br47; l35Ea", "gene_names_refseq": "BG:DS09217.5; CG4148; Dmel\\CG4148; WECKLE; Wek; l(2)35Ea; l(2)br47; l35Ea; wek", "protein_names_uniprotkb": "Zinc finger protein weckle", "protein_names_refseq": "CG4148-PB; lethal(2)35Ea; weckle, isoform B; weckle; wek-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4148); (R-DME-214842); (R-DME-214844); (R-DME-214862); (R-DME-214863); (R-DME-214869); (R-DME-214874)", "pathway_count": 7, "publication_count": 22, "publication_id_list": "10072384;10660298;10731132;11532919;11934858;12537568;12537572;12537573;12537574;14685264;16110336;16782008;17569856;17569867;18327897;25589440;26109356;26109357;8948598;9367441;9405646;9806920", "class_list": "", "function": "Acts as an adapter to assemble/stabilize a Toll/wek/Myd88/tube complex; required for efficient recruitment of Myd88 to Toll. Dispensable for innate immune response; plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi. Involved in dorsoventral axis determination., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0035591 signaling adaptor activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0008063 Toll signaling pathway;GO:0009950 dorsal/ventral axis specification;GO:0007311 maternal specification of dorsal/ventral axis, oocyte, germ-line encoded", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9VJN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W549-1", "uniprot_id": "COA8_DROME", "mass": 20800.0, "length": 176, "protein_name": "COA8 family protein CG14806, mitochondrial", "gene_name": "Coa8; coa8", "organism": "Fruit fly", "refseq_name": "cytochrome c oxidase assembly factor 8, isoform B", "refseq_ac": "NP_001259147", "gene_names_uniprotkb": "Coa8; coa8; Apop1; CG14806; Dmel\\CG14806; Dmel_CG14806; dCOA8", "gene_names_refseq": "Apop1; CG14806; Coa8; Dmel\\CG14806; dCOA8", "protein_names_uniprotkb": "COA8 family protein CG14806, mitochondrial; APOPT1 family protein CG14806, mitochondrial; COA8; Cytochrome c oxidase assembly factor 8", "protein_names_refseq": "CG14806-PB; Coa8-PB; cytochrome c oxidase assembly factor 8, isoform B", "tax_id": 7227, "disease": "mitochondrial complex IV deficiency nuclear type 17 (Disease Ontology:DOID:0070502)", "pathway": " (dme:Dmel_CG14806)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;22851751;25589440;26109356;26109357", "class_list": "", "function": "(Microbial infection) Required for optimal replication of E.chaffeensis., [UniProtKB, PubMed]; May be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0099617 matrix side of mitochondrial inner membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0097193 intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W549-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W5U2-1", "uniprot_id": "CHI10_DROME", "mass": 258777.0, "length": 2286, "protein_name": "Probable chitinase 10", "gene_name": "Cht10", "organism": "Fruit fly", "refseq_name": "chitinase 10, isoform A", "refseq_ac": "NP_001036422", "gene_names_uniprotkb": "Cht10; BcDNA:LP04696; CG17682; CG18140-PA3; CG18140; CHT1; CHT3; Cht1; Cht3; Cht; DmCHT10; DmCHT1; DmCHT3; DmCht10; DmCht1; DmCht3; Dmel\\CG18140; Dmel_CG18140; cht10; cht1; cht3", "gene_names_refseq": "BcDNA:LP04696; CG17682; CG18140-PA3; CG18140; CHT1; CHT3; Cht10; Cht1; Cht3; Cht; DmCHT10; DmCHT1; DmCHT3; DmCht10; DmCht1; DmCht3; Dmel\\CG18140; cht10; cht1; cht3", "protein_names_uniprotkb": "Probable chitinase 10; 3.2.1.14; Probable chitinase 1; Probable chitinase 3", "protein_names_refseq": "CG18140-PA; Cht10-PA; chitinase 10, isoform A; chitinase 1; chitinase 3; chitinase-1; chitinase-3", "tax_id": 7227, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); colorectal carcinoma (Disease Ontology:DOID:0080199); leprosy (Disease Ontology:DOID:1024); prostate carcinoma (Disease Ontology:DOID:10286); asbestosis (Disease Ontology:DOID:10320); silicosis (Disease Ontology:DOID:10325); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sarcoidosis (Disease Ontology:DOID:11335); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); allergic disease (Disease Ontology:DOID:1205); temporal arteritis (Disease Ontology:DOID:13375); pulmonary sarcoidosis (Disease Ontology:DOID:13406); aspergillosis (Disease Ontology:DOID:13564); endometrial cancer (Disease Ontology:DOID:1380); cystic fibrosis (Disease Ontology:DOID:1485); candidiasis (Disease Ontology:DOID:1508); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); Gaucher's disease (Disease Ontology:DOID:1926); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); glioblastoma (Disease Ontology:DOID:3068); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); chondrosarcoma (Disease Ontology:DOID:3371); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); allergic rhinitis (Disease Ontology:DOID:4481); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); neuromyelitis optica (Disease Ontology:DOID:8869); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); intrinsic asthma (Disease Ontology:DOID:9360); allergic asthma (Disease Ontology:DOID:9415); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); bronchiectasis (Disease Ontology:DOID:9563); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG18140); (R-DME-189085); (R-DME-6798695)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9662472", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 50, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O17420;O17422;Q7PL80;Q8MS85;Q9W5U3", "ec_number_list": "3.2.1.17;1.1.1.42;3.5.1.28;3.2.1.14;3.5.3.1;4.1.2.13;3.1.3.48;1.16.3.1;2.7.1.35;2.3.2.5;3.4.19.9;3.4.24.-;2.7.10.2;3.6.1.5;3.5.1.3;3.3.2.6;3.5.4.5;5.4.2.2;3.4.17.13;3.2.1.-", "go_molecular_function": "GO:0004568 chitinase activity;GO:0008843 endochitinase activity;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0000272 polysaccharide catabolic process;GO:0006032 chitin catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W5U2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2S5-1", "uniprot_id": "Q9W2S5_DROME", "mass": 231587.0, "length": 2139, "protein_name": "X11Lbeta, isoform A", "gene_name": "X11Lbeta", "organism": "Fruit fly", "refseq_name": "X11Lbeta, isoform A", "refseq_ac": "NP_727440", "gene_names_uniprotkb": "X11Lbeta; CG1852; CG1861; CG32677; Dmel\\CG32677; Dmel_CG32677; Dmint2; X11B; X11LB; X11lbeta; x11Lbeta", "gene_names_refseq": "CG1852; CG1861; CG32677; Dmel\\CG32677; Dmint2; X11B; X11LB; X11Lbeta; X11lbeta; x11Lbeta", "protein_names_uniprotkb": "X11Lbeta, isoform A", "protein_names_refseq": "CG32677-PA; X11Lbeta, isoform A; X11Lbeta-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32677); (R-DME-212676)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:0072657 protein localization to membrane;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2S5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GNL3-1", "uniprot_id": "FEND_DROME", "mass": 34626.0, "length": 321, "protein_name": "Transmembrane protein fend", "gene_name": "fend", "organism": "Fruit fly", "refseq_name": "forked end, isoform C", "refseq_ac": "NP_001259372", "gene_names_uniprotkb": "fend; BcDNA:RH56795; CG12664; Dmel\\CG12664; Dmel_CG12664; LD14; ld14", "gene_names_refseq": "BcDNA:RH56795; CG12664; Dmel\\CG12664; Dromel_CG12664_FBtr0071349_ld14_mORF; LD14; fend; ld14", "protein_names_uniprotkb": "Transmembrane protein fend; Protein forked end", "protein_names_refseq": "CG12664-PC; fend-PC; forked end, isoform C; forked end; ld14", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12664)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;11984842;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in the normal targeting of ventral muscle, muscle 12, by motoneurons. May function as an axon guidance molecule involved in neuromuscular specificity., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9W387", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9GNL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VX32-1", "uniprot_id": "RG190_DROME", "mass": 178772.0, "length": 1561, "protein_name": "Rho GTPase-activating protein 190", "gene_name": "RhoGAPp190", "organism": "Fruit fly", "refseq_name": "Rho GTPase activating protein p190, isoform D", "refseq_ac": "NP_001259656", "gene_names_uniprotkb": "RhoGAPp190; 8267; BcDNA:GH17919; BcDNA:GM05133; CG32555; CG8240; CG8267; D-p190; DRhoGAP; Dmel\\CG32555; Dmel_CG32555; RhoGAP P190; RhoGAP-16B12; RhoGAP; RhoGap190; mdcds_56566; p190 RhoGAP; p190-RhoGAP; p190RhoGAP; p190", "gene_names_refseq": "8267; BcDNA:GH17919; BcDNA:GM05133; CG32555; CG8240; CG8267; D-p190; DRhoGAP; Dmel\\CG32555; RhoGAP P190; RhoGAP-16B12; RhoGAPp190; RhoGAP; RhoGap190; mdcds_56566; p190 RhoGAP; p190-RhoGAP; p190RhoGAP; p190", "protein_names_uniprotkb": "Rho GTPase-activating protein 190; Rho GTPase-activating protein of 190 kDa", "protein_names_refseq": "CG32555-PD; Rho GTPase activating protein p190, isoform D; RhoGAPp190-PD; Rp190RhoGAP", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32555); (R-DME-350407); (R-DME-8849471); (R-DME-8980692); (R-DME-9013148); (R-DME-9013149); (R-DME-9013406); (R-DME-9013409); (R-DME-9013423); (R-DME-9035034)", "pathway_count": 10, "publication_count": 15, "publication_id_list": "10731132;11672527;12537568;12537569;12537572;12537573;12537574;16110336;17227793;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRC6;Q95VZ5", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0030215 semaphorin receptor binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007266 Rho protein signal transduction;GO:0045792 negative regulation of cell size;GO:0008361 regulation of cell size;GO:0007415 defasciculation of motor neuron axon", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VX32-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVT5-1", "uniprot_id": "DTBP1_DROME", "mass": 32364.0, "length": 288, "protein_name": "Dysbindin protein homolog", "gene_name": "Dysb", "organism": "Fruit fly", "refseq_name": "dysbindin, isoform B", "refseq_ac": "NP_001262023", "gene_names_uniprotkb": "Dysb; CG6856; Ddysb; Dmel\\CG6856; Dmel_CG6856; NP_649064; dysbindin; dysb", "gene_names_refseq": "CG6856; Ddysb; Dmel\\CG6856; Dysb; NP_649064; dysbindin; dysb", "protein_names_uniprotkb": "Dysbindin protein homolog; BLOC-1 subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8", "protein_names_refseq": "CG6856-PB; Dysb-PB; dysbindin ortholog; dysbindin, isoform B; dysbindin", "tax_id": 7227, "disease": "Hermansky-Pudlak syndrome 7 (Disease Ontology:DOID:0060545); platelet storage pool deficiency (Disease Ontology:DOID:2223); temporal lobe epilepsy (Disease Ontology:DOID:3328); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); schizophrenia (Disease Ontology:DOID:5419); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (dme:Dmel_CG6856)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;20015953;25589440;26109356;26109357;28317021", "class_list": "", "function": "Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis and membrane trafficking in synapses (PubMed:20015953, PubMed:28317021). In response to high synaptic activity at neuromuscular junctions, stabilizes Pldn protein levels and, together with Pldn, plays a role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes (PubMed:28317021)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0008021 synaptic vesicle;GO:0031083 BLOC-1 complex;GO:0098527 neuromuscular junction of somatic muscle;GO:0005737 cytoplasm", "go_biological_process": "GO:0008057 eye pigment granule organization;GO:0036466 synaptic vesicle recycling via endosome;GO:0008344 adult locomotory behavior;GO:0007614 short-term memory;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VVT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9XZS8-1", "uniprot_id": "ATF3_DROME", "mass": 65161.0, "length": 613, "protein_name": "Activating transcription factor 3", "gene_name": "Atf3", "organism": "Fruit fly", "refseq_name": "activating transcription factor 3, isoform C", "refseq_ac": "NP_001284769", "gene_names_uniprotkb": "Atf3; A3-3; ATF3; CG11405; DM11; Dmel\\CG11405; Dmel_CG11405; EG:33C11.1; atf3; dATF3", "gene_names_refseq": "A3-3; ATF3; Atf3; CG11405; DM11; Dmel\\CG11405; EG:33C11.1; atf3; dATF3", "protein_names_uniprotkb": "Activating transcription factor 3", "protein_names_refseq": "A3-3; Atf3-PC; CG11405-PC; activating transcription factor 3, isoform C", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283); pulmonary tuberculosis (Disease Ontology:DOID:2957)", "pathway": " (dme:Dmel_CG11405); (R-DME-2559580); (R-DME-2871796); (R-DME-450341)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;20023169;22851689;25589440;26109356;26109357;26848073", "class_list": "", "function": "Transcription factor which binds to the cAMP response element (CRE) (PubMed:20023169). Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut (PubMed:22851689). Required for the expression of odorant receptors Or43b and Or47b (PubMed:26848073)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRE5", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006955 immune response;GO:0055088 lipid homeostasis;GO:0010883 regulation of lipid storage", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9XZS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VA91-1", "uniprot_id": "RS7_DROME", "mass": 22170.0, "length": 194, "protein_name": "Small ribosomal subunit protein eS7", "gene_name": "RpS7", "organism": "Fruit fly", "refseq_name": "ribosomal protein S7, isoform A", "refseq_ac": "NP_651782", "gene_names_uniprotkb": "RpS7; CG1883; Dmel\\CG1883; Dmel_CG1883; S7e", "gene_names_refseq": "CG1883; Dmel\\CG1883; RpS7; S7e", "protein_names_uniprotkb": "Small ribosomal subunit protein eS7; 40S ribosomal protein S7", "protein_names_refseq": "CG1883-PA; RpS7-PA; ribosomal protein S7, isoform A; ribosomal protein S7", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 8 (Disease Ontology:DOID:0111881)", "pathway": " (dme:Dmel_CG1883); (R-DME-156827); (R-DME-1799339); (R-DME-6791226); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 13, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3N0", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit;GO:0005840 ribosome", "go_biological_process": "GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VA91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLK4-1", "uniprot_id": "DIUX_DROME", "mass": 12622.0, "length": 116, "protein_name": "Diuretic hormone class 2", "gene_name": "Dh31", "organism": "Fruit fly", "refseq_name": "diuretic hormone 31, isoform A", "refseq_ac": "NP_523514", "gene_names_uniprotkb": "Dh31; CG13094; DH 31; DH-II; DH31; DH[31]; DH[[31]]; DH[[31]; Dh[[31]]; Dmel\\CG13094; Dmel_CG13094; Drm-DH[[31]]; Drome-DH[[31]]; anon-EST:Posey114; anon-WO02059370.45; dh31; drome-DH31", "gene_names_refseq": "CG13094; DH 31; DH-II; DH31; DH[31]; DH[[31]]; DH[[31]; Dh31; Dh[[31]]; Dmel\\CG13094; Drm-DH[[31]]; Drome-DH[[31]]; anon-EST:Posey114; anon-WO02059370.45; dh31; drome-DH31", "protein_names_uniprotkb": "Diuretic hormone class 2; DH(31); DP; Diuretic peptide", "protein_names_refseq": "CG13094-PA; Calcitonin-like diuretic hormone (31 residues); Dh31-PA; calcitonin; diuretic hormone 31, isoform A; diuretic hormone 31; diuretic hormone", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13094)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;11316500;12537568;12537572;12537573;12537574;16110336;17569856;17569867;21214272;25589440;26109356;26109357", "class_list": "", "function": "Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0008613 diuretic hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009266 response to temperature stimulus;GO:0007589 body fluid secretion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VLK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VRL1-1", "uniprot_id": "Q9VRL1_DROME", "mass": 16669.0, "length": 145, "protein_name": "Ubiquitin-conjugating enzyme variant 1A, isoform A; Ubiquitin-conjugating enzyme variant 1A, isoform C", "gene_name": "Uev1A", "organism": "Fruit fly", "refseq_name": "Ubiquitin-conjugating enzyme variant 1A, isoform C", "refseq_ac": "NP_001286940", "gene_names_uniprotkb": "Uev1A; CG10640; DmUEV; DmUev1a; Dmel\\CG10640; Dmel_CG10640; UEV1A; UEV1a; UEV; Uev1a; dUEV1A; dUEV1a; dUev1A; uev1a", "gene_names_refseq": "CG10640; DmUEV; DmUev1a; Dmel\\CG10640; UEV1A; UEV1a; UEV; Uev1A; Uev1a; dUEV1A; dUEV1a; dUev1A; uev1a", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme variant 1A, isoform A; Ubiquitin-conjugating enzyme variant 1A, isoform C", "protein_names_refseq": "CG10640-PC; Ubiquitin-conjugating enzyme variant 1A, isoform C; Uev1A-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10640); (R-DME-209447); (R-DME-214399); (R-DME-445989); (R-DME-5205685); (R-DME-9020702); (R-DME-937039); (R-DME-9646399); (R-DME-975144); (R-DME-983168)", "pathway_count": 10, "publication_count": 18, "publication_id_list": "10731132;11018014;12537568;12537572;12537573;12537574;12732719;14519762;16081424;16110336;16311020;16894030;17158449;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0031372 UBC13-MMS2 complex", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0046330 positive regulation of JNK cascade;GO:0000209 protein polyubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VRL1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSH3-1", "uniprot_id": "BI1_DROME", "mass": 27574.0, "length": 245, "protein_name": "Bax inhibitor 1", "gene_name": "BI-1", "organism": "Fruit fly", "refseq_name": "Bax Inhibitor-1, isoform A", "refseq_ac": "NP_648205", "gene_names_uniprotkb": "BI-1; CG7188; Dmel\\CG7188; Dmel_CG7188; d-BI-1; dBI-1; dTmbim6", "gene_names_refseq": "BI-1; CG7188; Dmel\\CG7188; d-BI-1; dBI-1; dTmbim6", "protein_names_uniprotkb": "Bax inhibitor 1", "protein_names_refseq": "BI-1-PA; Bax Inhibitor-1, isoform A; Bax inhibitor-1; CG7188-PA", "tax_id": 7227, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); invasive ductal carcinoma (Disease Ontology:DOID:3008); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)", "pathway": " (dme:Dmel_CG7188)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;19328063;21926971;25589440;26109356;26109357", "class_list": "", "function": "Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling (PubMed:19328063). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (PubMed:21926971)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0060698 endoribonuclease inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response;GO:0043066 negative regulation of apoptotic process;GO:0006816 calcium ion transport;GO:0006915 apoptotic process;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VSH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q95TS5-1", "uniprot_id": "INT9_DROME", "mass": 73272.0, "length": 654, "protein_name": "Integrator complex subunit 9", "gene_name": "IntS9", "organism": "Fruit fly", "refseq_name": "integrator 9", "refseq_ac": "NP_648838", "gene_names_uniprotkb": "IntS9; CG5222", "gene_names_refseq": "CG5222; Dmel\\CG5222; Int9; IntS9; Ints9", "protein_names_uniprotkb": "Integrator complex subunit 9", "protein_names_refseq": "CG5222-PA; IntS9-PA; integrator 9", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5222); (R-DME-6807505)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537569;12537572;21078872;23097424;23288851;31530651;31809743;32966759;36180473;37995689;39032490", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:21078872, PubMed:23097424, PubMed:32966759). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity (PubMed:32966759). The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUY5", "ec_number_list": "", "go_molecular_function": "GO:0000822 inositol hexakisphosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q95TS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q961D9-1", "uniprot_id": "BCL9_DROME", "mass": 153759.0, "length": 1469, "protein_name": "Protein BCL9 homolog", "gene_name": "lgs", "organism": "Fruit fly", "refseq_name": "legless", "refseq_ac": "NP_651922", "gene_names_uniprotkb": "lgs; BCL9; CG2041", "gene_names_refseq": "BCL9; Bcl9/9l; CG2041; Dm Lgs; Dmel\\CG2041; Lgl; Lgs; lgs", "protein_names_uniprotkb": "Protein BCL9 homolog; Protein legless", "protein_names_refseq": "CG2041-PA; legless; lgs-PA", "tax_id": 7227, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411)", "pathway": " (dme:Dmel_CG2041); (R-DME-201722); (R-DME-209407); (R-DME-209421)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10731132;11955446;12537569;12537572;12636921;15043810;15208637;15294866;15768032;16169192;16554443;18327897", "class_list": "", "function": "Involved in signal transduction through the Wnt pathway., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9V4D2", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060070 canonical Wnt signaling pathway;GO:0007491 sternite morphogenesis;GO:0007367 segment polarity determination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q961D9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99323-3", "uniprot_id": "MYSN_DROME", "mass": 236629.0, "length": 2056, "protein_name": "Myosin heavy chain, non-muscle", "gene_name": "zip", "organism": "Fruit fly", "refseq_name": "zipper, isoform A", "refseq_ac": "NP_523860", "gene_names_uniprotkb": "zip; CG15792", "gene_names_refseq": "CG15792; DROMHC; Dm nmII; Dmel\\CG15792; DmnmII; Dronm-MII; E(br); MHC; Mhc-c[1]; Mhc-c; Myo II; Myo-II HC; Myo-II; Myo15; Myo2; MyoII; Myosin II; Myosin-II; Myo; NMII; NMMII; NMM; ZIP; Zip; actomyosin; anon-WO0140519.37; cbe; l(2)02957; l(2)17F1; myo II; myoII; myosin II; myosin-II; nmMHC; nmy-2; zip/MyoII; zip; zpr", "protein_names_uniprotkb": "Myosin heavy chain, non-muscle; Myosin II; Non-muscle MHC; Protein zipper", "protein_names_refseq": "CG15792-PA; MyoII heavy chain; Myosin-2; Myosin-II; actomyosin; celibe; cytoplasmic myosin II; cytoplasmic myosin heavy chain; cytoplasmic myosin-II; enhancer of broad; lethal (2) 17F1; myo-II heavy chain; myosin 2; myosin HC; myosin heavy chain-cytoplasmic; myosin heavy chain; myosin-heavy-chain-cytoplasmic; myosins II; non muscle myosin; non-muscle myosin II heavy chain; non-muscle myosin II; non-muscle myosin heavy-chain; non-muscle myosin-II; nonmuscle MyoII; nonmuscle myosin II heavy chain; nonmuscle myosin II heavychain; nonmuscle myosin heavy chain; nonmuscle myosin-II heavy chain; nonmuscle myosin-II; zip-PA; zipper heavy chain; zipper, isoform A", "tax_id": 7227, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); metabolic acidosis (Disease Ontology:DOID:0050758); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); MYH-9 related disease (Disease Ontology:DOID:0060651); Alport syndrome 3A (Disease Ontology:DOID:0110032); autosomal dominant nonsyndromic deafness 17 (Disease Ontology:DOID:0110548); autosomal dominant nonsyndromic deafness 4A (Disease Ontology:DOID:0110573); sensorineural hearing loss (Disease Ontology:DOID:10003); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); thrombocytopenia (Disease Ontology:DOID:1588); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (dme:Dmel_CG15792); (R-DME-350480); (R-DME-445355)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10570971;10731132;11301004;11874917;12537572;15269282;18327897;18816840;2117279;23579691;24786584;27331610;31704968;8568878", "class_list": "", "function": "Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis (PubMed:24786584). Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in scolopidial apical attachment (PubMed:27331610). Interaction with the myosin ck may be important for this function (PubMed:27331610). Localizes to and defines the trailing edge of cells during larval epidermal wound healing (PubMed:31704968). This process is dependent on the phosphatidylinositol 4-phosphate 5-kinase sktl/skittles (PubMed:31704968)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24138;Q59E58;Q59E59;Q7JPC1;Q7JPC2;Q8MMC2;Q94987;Q94992;Q9W0W8", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0032027 myosin light chain binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0005938 cell cortex", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0006936 muscle contraction;GO:0007605 sensory perception of sound;GO:0000281 mitotic cytokinesis;GO:0071260 cellular response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99323-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GSR1-1", "uniprot_id": "DPOZ_DROME", "mass": 240073.0, "length": 2130, "protein_name": "DNA polymerase zeta catalytic subunit", "gene_name": "PolZ1", "organism": "Fruit fly", "refseq_name": "DNA polymerase zeta subunit 1", "refseq_ac": "NP_524881", "gene_names_uniprotkb": "PolZ1; CG1925; DNApol-zeta; DNApolZ1; Dmpolzeta; mus205; rev3", "gene_names_refseq": "154926_at; AAF59191; CG1925; DNApol-zeta; DhRev3; DmREV3; Dmel\\CG1925; Dmpolzeta; Mus205; PolZ1; Rev3; mus 205; mus(2)205; mus-205; mus205; rev3", "protein_names_uniprotkb": "DNA polymerase zeta catalytic subunit; 2.7.7.7", "protein_names_refseq": "CG1925-PA; DNA polymerase zeta catalytic subunit; DNA polymerase zeta subunit 1; PolZ1-PA; mutagen-sensitive 205", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1925); (R-DME-110312); (R-DME-5655862); (R-DME-5656121); (R-DME-5656169)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;11267835;12537572;15175013;16507570;22532806", "class_list": "", "function": "As the catalytic subunit of the DNA polymerase zeta complex, plays a crucial role in translesion DNA synthesis (TLS) and various DNA repair mechanisms (PubMed:11267835, PubMed:15175013, PubMed:16507570, PubMed:22532806). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function (PubMed:15175013). During homologous recombination (HR) repair, has a overlapping role with the error-prone translesion polymerase eta to initiate repair synthesis which is completed by end joining or another polymerase that can bind and reinitiate synthesis (PubMed:22532806). May participate in the Rrp1-dependent base excision repair (BER) pathway responsible for repair of DNA lesions that gives rise to apurinic/apyrimidinic (AP) sites (PubMed:16507570). Unlike mammalian orthologs, it is not an error-prone polymerase (PubMed:15175013)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95TM2;Q9GSR2;Q9V319", "ec_number_list": "2.7.7.7;3.1.11.-;2.7.7.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0000724 double-strand break repair via homologous recombination;GO:0000731 DNA synthesis involved in DNA repair;GO:0042276 error-prone translesion synthesis;GO:0043150 DNA synthesis involved in double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9GSR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GYU8-1", "uniprot_id": "NUP88_DROME", "mass": 78681.0, "length": 702, "protein_name": "Nuclear pore complex protein Nup88", "gene_name": "mbo", "organism": "Fruit fly", "refseq_name": "members only", "refseq_ac": "NP_524330", "gene_names_uniprotkb": "mbo; CG6819; Nup88", "gene_names_refseq": "1465/07; 1465/7; CG6819; DNup88; Dmel\\CG6819; Dnup 88; Dnup88; MBO; Mbo; NUP88; Nup88; anon-WO0118547.263; dNup88; l(3)05043; l(3)S146507; mbo; nup88", "protein_names_uniprotkb": "Nuclear pore complex protein Nup88; 88 kDa nuclear pore complex protein; Nucleoporin Nup88; Protein members only; dNup88", "protein_names_refseq": "CG6819-PA; mbo-PA; members only", "tax_id": 7227, "disease": "fetal akinesia deformation sequence syndrome 4 (Disease Ontology:DOID:0111379)", "pathway": " (dme:Dmel_CG6819); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 10, "publication_id_list": "10731132;10921908;12537569;12537572;12653959;14638854;15086791;17032737;18327897;20144761", "class_list": "", "function": "Essential component of nuclear pore complex (PubMed:10921908, PubMed:14638854, PubMed:17032737). Required for the anchoring of Nup214 and emb on the nuclear envelope and thereby attenuates nuclear export signal (NES)-mediated nuclear export (PubMed:14638854). Together with Nup214, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response (PubMed:10921908, PubMed:17032737)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VG41", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0019730 antimicrobial humoral response;GO:0046826 negative regulation of protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9GYU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9GYV9-1", "uniprot_id": "MED7_DROME", "mass": 25707.0, "length": 220, "protein_name": "Mediator of RNA polymerase II transcription subunit 7", "gene_name": "MED7", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 7", "refseq_ac": "NP_731500", "gene_names_uniprotkb": "MED7; CG31390", "gene_names_refseq": "CG31390; CG6529; Dmel\\CG31390; MED7; Med7; dMED7; dTRAP34", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 7; Mediator complex subunit 7; dMED7", "protein_names_refseq": "CG31390-PA; MED7-PA; mediator complex subunit 7; mediator", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31390)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;15477388;16751183", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ36", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9GYV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I7D3-1", "uniprot_id": "CAPR1_DROME", "mass": 103590.0, "length": 961, "protein_name": "Caprin homolog", "gene_name": "Capr", "organism": "Fruit fly", "refseq_name": "caprin, isoform B", "refseq_ac": "NP_001287107", "gene_names_uniprotkb": "Capr; CG18811", "gene_names_refseq": "CG18811; Capr; Dmel\\CG18811; NEST:bs19b07; anon-WO0118547.253; capr; dCaprin; dFAP", "protein_names_uniprotkb": "Caprin homolog", "protein_names_refseq": "CG18811-PB; Capr-PB; caprin, isoform B; caprin; dFMRP-associated protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18811)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;16979555;17372656;18327897;33925313", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0009794 regulation of mitotic cell cycle, embryonic;GO:0007349 cellularization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9I7D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I7I7-1", "uniprot_id": "SIRT2_DROME", "mass": 43449.0, "length": 386, "protein_name": "NAD-dependent protein deacetylase Sirt2", "gene_name": "Sirt2", "organism": "Fruit fly", "refseq_name": "sirtuin 2, isoform D", "refseq_ac": "NP_001287422", "gene_names_uniprotkb": "Sirt2; CG5085", "gene_names_refseq": "CG5085; D.mel2; DmSir2; Dmel\\CG5085; SIRT2; Sir2; Sirt2; dSIRT2; dsirt2; sirt2", "protein_names_uniprotkb": "NAD-dependent protein deacetylase Sirt2; 2.3.1.286; Protein Sirtuin 2; Regulatory protein SIR2 homolog; SIR2-related protein", "protein_names_refseq": "CG5085-PD; Sirt2-PD; drosophila sirtuin 2; sirtuin 2, isoform D; sirtuin", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); high grade glioma (Disease Ontology:DOID:3070); intermittent claudication (Disease Ontology:DOID:3669); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG5085); (R-DME-2995383)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;16219773;17159295", "class_list": "", "function": "NAD-dependent protein deacetylase (By similarity). Acts as a histone deacetylase (PubMed:16219773). Involved in repression of retrotransposon transcription, including of copia retrotransposons (PubMed:16219773). May be involved in the regulation of life span (PubMed:17159295)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LHF9;R4HZM7", "ec_number_list": "2.3.1.286", "go_molecular_function": "GO:0046872 metal ion binding;GO:0070403 NAD+ binding;GO:0004407 histone deacetylase activity;GO:0017136 histone deacetylase activity, NAD-dependent;GO:0033558 protein lysine deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0042594 response to starvation;GO:0000183 rDNA heterochromatin formation;GO:1903862 positive regulation of oxidative phosphorylation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9I7I7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I7X6-2", "uniprot_id": "CARME_DROME", "mass": 52441.0, "length": 456, "protein_name": "Carnosine N-methyltransferase unmet", "gene_name": "unmet", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform D", "refseq_ac": "NP_001259154", "gene_names_uniprotkb": "unmet; CG11596", "gene_names_refseq": "CG11596; Dmel\\CG11596; EG:39E1.1", "protein_names_uniprotkb": "Carnosine N-methyltransferase unmet; 2.1.1.22; Protein unmet expectations", "protein_names_refseq": "CG11596-PD; uncharacterized protein, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11596); (R-DME-70921)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;10731137;12537569;12537572;17372656;18327897;38514639", "class_list": "", "function": "S-adenosyl-L-methionine-binding protein that acts as a sensor to signal methionine availability to the mTORC1 signaling pathway (PubMed:38514639). Associates with the GATOR2 complex in the absence of methionine to inhibit mTORC1 signaling, but dissociates in the presence of the methionine derivative S-adenosyl-L-methionine; S-adenosyl-L-homocysteine binding does not induce dissociation (PubMed:38514639). Required for mTORC1 pathway response to methionine starvation (PubMed:38514639). Exerts a protective function on developing egg chambers by inhibiting mTORC1 signaling under starvation conditions (PubMed:38514639). May also function as a N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine (By similarity). It is unclear whether this protein has retained N-methyltransferase activity or if it is an evolutionary intermediate whose substrate binding ability has been co-opted to function as a nutrient sensor for mTORC1 signaling (Probable)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E4NKI7;M9PGG7;O46078;Q7KW04;Q9W540", "ec_number_list": "2.1.1.22", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0030735 carnosine N-methyltransferase activity;GO:0140785 amino acid sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0034198 cellular response to amino acid starvation;GO:1904262 negative regulation of TORC1 signaling;GO:0035498 carnosine metabolic process;GO:0061431 cellular response to methionine", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9I7X6-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NBD7-1", "uniprot_id": "CLASP_DROME", "mass": 165576.0, "length": 1491, "protein_name": "CLIP-associating protein", "gene_name": "chb", "organism": "Fruit fly", "refseq_name": "chromosome bows, isoform A", "refseq_ac": "NP_524651", "gene_names_uniprotkb": "chb; CG32435; CLASP; MESR7; Mast; orbit", "gene_names_refseq": "0686/07; BcDNA:LD31673; CG32435; CLASP; Chb; DMAP160; Dmel\\CG32435; MAST/Orbit; MAST; MESR7; Mast/Orbit; Mast; NEST:bs13a06; NEST:bs17d05; NEST:bs28g05; Orbit/MAST; Orbit/Mast; Orbit; anon-WO0104295; chb(v40); chb/mast/orbit; chb; clasp; dCLASP; mast/orbit; mast; orbit/MAST; orbit/mast; orbit; orb; v40", "protein_names_uniprotkb": "CLIP-associating protein; Mast; Misexpression suppressor of ras 7; Protein Multiple asters; Protein Orbit; Protein chromosome bows", "protein_names_refseq": "CG32435-PA; MAST/Orbit; Orbit/MAST; Orbit/Mast/CLASP; chb-PA; chromosome bows, isoform A; clasp; mast; misexpression suppressor of ras 7; multiple asters; orbit/clasp", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32435)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;10747094;10899121;11063696;12034769;12537569;12537572;12538517;15207236;15240569;15592460;16303556;16723741;17372656;18327897", "class_list": "", "function": "Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for several aspects of mitotic spindle formation including the formation of the overlapping central spindle microtubules and kinetochore attachment. Required for the incorporation of tubulin subunits at the plus ends of kinetochore microtubules during poleward microtubule flux. Acts antagonistically to Klp10A and Klp67A to maintain metaphase spindle length. Also required for guidance of CNS axons downstream of Abl. May function to identify a subset of microtubules that probe the peripheral growth cone domain, where guidance signals exert their influence on cytoskeletal organization. Also required during oogenesis for the organization of the polarized microtubule network inside the 16-cell cyst that ensures oocyte differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V279;Q9NL57", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0045180 basal cortex;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0046602 regulation of mitotic centrosome separation;GO:0000278 mitotic cell cycle;GO:0090307 mitotic spindle assembly;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9NBD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NFP1-1", "uniprot_id": "VNNL1_DROME", "mass": 62342.0, "length": 558, "protein_name": "Vanin-like protein 1", "gene_name": "vanin-like", "organism": "Fruit fly", "refseq_name": "vanin-like", "refseq_ac": "NP_572297", "gene_names_uniprotkb": "vanin-like; CG32754", "gene_names_refseq": "CG32754; CG3648; Dmel\\CG32754; Vanin-like; vanin-like", "protein_names_uniprotkb": "Vanin-like protein 1; 3.5.1.-", "protein_names_refseq": "CG32754-PA; pantetheine hydrolase; vanin-like-PA; vanin-like", "tax_id": 7227, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); biotinidase deficiency (Disease Ontology:DOID:856)", "pathway": " (dme:Dmel_CG32754); (R-DME-196780)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10501839;10731132;12537569;12537572;17893096;25387828", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9W431", "ec_number_list": "3.5.1.-", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0017159 pantetheine hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0019898 extrinsic component of membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9NFP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NFT9-1", "uniprot_id": "HXK1_DROME", "mass": 52260.0, "length": 465, "protein_name": "Hexokinase-like protein", "gene_name": "Hexl", "organism": "Fruit fly", "refseq_name": "hexokinase testis 1", "refseq_ac": "NP_788744", "gene_names_uniprotkb": "Hexl; CG33102; DHK-465; Hex-t1; Hex", "gene_names_refseq": "CG33102; CG54430; CG5443; DHK-453; Dmel\\CG33102; HEX-t1; HK; Hex-T1; Hex-t1; Hex", "protein_names_uniprotkb": "Hexokinase-like protein; Inactive hexokinase-1", "protein_names_refseq": "CG33102-PA; Hex-t1-PA; Hexokinase-t1; hexokinase testis 1; hexokinase", "tax_id": 7227, "disease": "permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); retinitis pigmentosa 92 (Disease Ontology:DOID:0061107); familial hyperinsulinemic hypoglycemia 3 (Disease Ontology:DOID:0070216); maturity-onset diabetes of the young type 2 (Disease Ontology:DOID:0111100); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (dme:Dmel_CG33102); (R-DME-170822); (R-DME-446205); (R-DME-6798695); (R-DME-70171)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10731132;11063694;12537572", "class_list": "", "function": "Probable inactive hexokinase that may moonlight as a carbohydrate binding protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWE1;Q9VBF1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005536 D-glucose binding;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0019318 hexose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9NFT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NGX9-1", "uniprot_id": "CP302_DROME", "mass": 55574.0, "length": 489, "protein_name": "Cytochrome P450 302a1, mitochondrial", "gene_name": "dib", "organism": "Fruit fly", "refseq_name": "disembodied", "refseq_ac": "NP_524810", "gene_names_uniprotkb": "dib; CG12028; CYP302A1", "gene_names_refseq": "302a1; CG12028; CYP302A1; Cyp27; Cyp302a1; Cyp; Dib; Dmel\\CG12028; dib; l(3)64Ak; l(3)SH14; l(3)dib", "protein_names_uniprotkb": "Cytochrome P450 302a1, mitochondrial; 1.14.15.44; Protein disembodied", "protein_names_refseq": "CG12028-PA; cytochrome P450; dib-PA; disembodied", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12028)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10976044;12177427;12537572;12676319;14610274", "class_list": "", "function": "Required for CNS development; negatively regulates glial cell division in the embryonic midline. Involved in the metabolism of insect hormones; responsible for ecdysteroid C22-hydroxylase activity. May be involved in the breakdown of synthetic insecticides., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q059D3;Q9VZJ0", "ec_number_list": "1.14.15.44", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0042767 ecdysteroid 22-hydroxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0007417 central nervous system development;GO:0007494 midgut development;GO:0006697 ecdysone biosynthetic process;GO:0007391 dorsal closure;GO:0008258 head involution", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9NGX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NHX0-1", "uniprot_id": "RBX1B_DROME", "mass": 14225.0, "length": 122, "protein_name": "RING-box protein 1B", "gene_name": "Roc1b", "organism": "Fruit fly", "refseq_name": "regulator of cullins 1b", "refseq_ac": "NP_652613", "gene_names_uniprotkb": "Roc1b; CG16988; ROC2", "gene_names_refseq": "BcDNA:AT21612; CG16988; Dmel\\CG16988; ROC1B; ROC1b; ROC2; Roc1b; Roc2; Roc; dRoc1b; roc1b", "protein_names_uniprotkb": "RING-box protein 1B; Regulator of cullins 1b", "protein_names_refseq": "CG16988-PA; Roc1b-PA; regulator of cullins 1b", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG16988); (R-DME-216167)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10731132;12062088;12537569;12537572;15331761;16651542;16740475;17102630", "class_list": "", "function": "Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0R1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0097602 cullin family protein binding;GO:0061663 NEDD8 ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0019915 lipid storage;GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9NHX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NIV2-1", "uniprot_id": "STEL8_DROME", "mass": 19529.0, "length": 172, "protein_name": "Stellate orphon protein at 12D", "gene_name": "Ste12DOR", "organism": "Fruit fly", "refseq_name": "stellate 12D orphon", "refseq_ac": "NP_727747", "gene_names_uniprotkb": "Ste12DOR; CG32616", "gene_names_refseq": "CG32616; Dmel\\CG32616; SC-1; Ste12DOR; SteDOR; Ste", "protein_names_uniprotkb": "Stellate orphon protein at 12D", "protein_names_refseq": "CG32616-PB; Ste12DOR-PB; stellate 12D orphon; stellate orphon", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32616); (dme:Dmel_CG33237)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;11293788;11470406;11513298;12537572;7597082", "class_list": "", "function": "Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IR61", "ec_number_list": "", "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005956 protein kinase CK2 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9NIV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9NK57-1", "uniprot_id": "NIF3L_DROME", "mass": 32363.0, "length": 292, "protein_name": "NIF3-like protein 1", "gene_name": "36A", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_609790", "gene_names_uniprotkb": "36A; CG4278", "gene_names_refseq": "BG:DS02740.16; CG4278; Dmel\\CG4278; anon-35F/36A; un5", "protein_names_uniprotkb": "NIF3-like protein 1; Protein anon-35F/36A", "protein_names_refseq": "CG4278-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4278)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10471707;10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VJL4", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9NK57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9U3V9-2", "uniprot_id": "XMAS_DROME", "mass": 239476.0, "length": 2079, "protein_name": "Protein xmas", "gene_name": "xmas", "organism": "Fruit fly", "refseq_name": "xmas, isoform B", "refseq_ac": "NP_524773", "gene_names_uniprotkb": "xmas; CG46386; xmas-1; xmas-2", "gene_names_refseq": "CG32561; CG32562; CG46386; CG8919; Dmel\\CG46386; Xmas-2; Xmas; l(1)15Ea; m(1)3; ms(1)3; ms3; xmas-1; xmas-2; xmas", "protein_names_uniprotkb": "Protein xmas", "protein_names_refseq": "CG46386-PB; X-linked male sterile 2; transcript g; xmas, isoform B; xmas-1; xmas-2; xmas-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG46386)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;18034162;27016737;28472469;29779104;33602059;33689068", "class_list": "", "function": "Involved in mRNA export and mRNA coupled transcription activation (PubMed:18034162, PubMed:27016737, PubMed:33602059). Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex) which functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), thereby enabling the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:18034162, PubMed:27016737). The TREX-2/AMEX complex also functions with the transcriptional coactivator SAGA/TFTC complex, to anchor a subset of transcription sites to the nuclear pore complex basket in order to achieve efficient transcription and export of their resulting mRNAs (PubMed:18034162). Within the complex, required for localization of e(y)2 to the nuclear periphery (PubMed:18034162)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A4D6K557;C9QP61;D0IQ87;H1UUM5;Q8IR02;Q8MQS3;Q9U3V8;Q9VX76", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9U3V9-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9U4F3-1", "uniprot_id": "SURF1_DROME", "mass": 34064.0, "length": 300, "protein_name": "SURF1-like protein", "gene_name": "Surf1", "organism": "Fruit fly", "refseq_name": "surfeit 1", "refseq_ac": "NP_524758", "gene_names_uniprotkb": "Surf1; CG9943", "gene_names_refseq": "BcDNA:GH23574; CG9943; Dmel\\CG9943; SUR1; Surf1", "protein_names_uniprotkb": "SURF1-like protein", "protein_names_refseq": "CG9943-PA; Surf1-PA; surfeit 1; surfeit locus protein 1", "tax_id": 7227, "disease": "mitochondrial complex IV deficiency nuclear type 1 (Disease Ontology:DOID:0070491); Charcot-Marie-Tooth disease type 4K (Disease Ontology:DOID:0110187); Leigh disease (Disease Ontology:DOID:3652)", "pathway": " (dme:Dmel_CG9943); (R-DME-9864848)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10622737;10731132;12537569;12537572;16172499;25164807", "class_list": "", "function": "Probably involved in the biogenesis of the COX complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSH4;Q9VRZ8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9U4F3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9U4G1-1", "uniprot_id": "BDL_DROME", "mass": 81213.0, "length": 719, "protein_name": "Protein borderless", "gene_name": "bdl", "organism": "Fruit fly", "refseq_name": "borderless", "refseq_ac": "NP_608822", "gene_names_uniprotkb": "bdl; CG16857", "gene_names_refseq": "BcDNA:GH11322; CG16857; CT35491; Dmel\\CG16857; GH11322; bdl", "protein_names_uniprotkb": "Protein borderless", "protein_names_refseq": "CG16857-PA; bdl-PA; borderless", "tax_id": 7227, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dme:Dmel_CG16857); (R-DME-1474228); (R-DME-210991); (R-DME-216083); (R-DME-428542); (R-DME-433692); (R-DME-9749641)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10731132;10731138;12537569;12537572;24174674", "class_list": "", "function": "In the developing eye, has a role in axonal targeting of the R7 photoreceptor where it functions together with tutl. Probably mediates homotypic cell adhesion; the effect is inhibited by Lar., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0PTX2;Q95U86;Q9VQY3", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009416 response to light stimulus;GO:0007411 axon guidance;GO:0008366 axon ensheathment;GO:0007158 neuron cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9U4G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9U5W9-1", "uniprot_id": "TAF10_DROME", "mass": 18521.0, "length": 167, "protein_name": "Transcription initiation factor TFIID subunit 10", "gene_name": "Taf10", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 10", "refseq_ac": "NP_477463", "gene_names_uniprotkb": "Taf10; CG2859", "gene_names_refseq": "BcDNA:RE73934; CG2859; Dmel\\CG2859; TAF10; TAF[[II]]24; TAF[[II]]; TAF; TFIID; Taf10; Taf24; TafII24; dTAF10; dTAFII24; dTAF[[II]]24; dmTAF10; dmTaf10; dtafII24; taf10; taf24", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 10; TAFII-24; TAFII24; Transcription initiation factor TFIID 24 kDa subunit; dTAF(II)24", "protein_names_refseq": "CG2859-PA; TBP-associated factor 10; TBP-associated factor 24kD; TBP-associated factor; Taf10-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2859)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10669741;10731132;11134347;12537569;12537572", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VQG3", "ec_number_list": "", "go_molecular_function": "GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9U5W9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9U6M0-1", "uniprot_id": "ECSIT_DROME", "mass": 47065.0, "length": 409, "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "gene_name": "ECSIT", "organism": "Fruit fly", "refseq_name": "ECSIT", "refseq_ac": "NP_649602", "gene_names_uniprotkb": "ECSIT; CG10610", "gene_names_refseq": "CG10610; DmECSIT; Dmel\\CG10610; ECSIT; dECSIT", "protein_names_uniprotkb": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Protein ECSIT", "protein_names_refseq": "CG10610-PA; ECSIT-PA; ECSIT", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10610); (R-DME-6799198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10465784;10731132;12537569;12537572;34386730", "class_list": "", "function": "As part of the MCIA complex, involved in the assembly of the mitochondrial complex I (Probable). Involved in the innate immune response; promotes the production of antibacterial peptides., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZF7;Q9VNJ6", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004857 enzyme inhibitor activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0160295 mitochondrial complex I intermediate assembly complex", "go_biological_process": "GO:0045087 innate immune response;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0034142 toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9U6M0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3H2-1", "uniprot_id": "PSDE_DROME", "mass": 34401.0, "length": 308, "protein_name": "26S proteasome non-ATPase regulatory subunit 14", "gene_name": "Rpn11", "organism": "Fruit fly", "refseq_name": "regulatory particle non-ATPase 11", "refseq_ac": "NP_608905", "gene_names_uniprotkb": "Rpn11; CG18174; yip5", "gene_names_refseq": "37B; CG18174; DmS13; Dmel\\CG18174; PSMD14; Q9V3H2; RPN11; RPn11; Rpn11; S13; p37B; rpn11; yip5", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory complex subunit p37B; 26S proteasome regulatory subunit rpn11; 3.4.19.-; Yippee-interacting protein 5", "protein_names_refseq": "CG18174-PA; Rpn11-PA; regulatory particle non-ATPase 11; yippee interacting protein 5", "tax_id": 7227, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658)", "pathway": " (dme:Dmel_CG18174); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-5689901); (R-DME-6798695); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 58, "publication_count": 36, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;10893261;11585911;12231619;12432393;12442174;12537569;12537572;12973300;15178801;15258584;15331761;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17925225;18519643;18593878;19185492;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9NIU3", "ec_number_list": "2.4.1.186;5.4.2.7;5.4.2.-;3.2.1.31;2.3.2.27;1.1.1.42;2.4.2.1;2.7.11.24;2.7.1.40;2.7.11.1;4.1.2.13;2.7.4.6;2.7.11.11;2.4.2.7;3.6.5.-;1.11.1.6;3.1.3.48;2.7.11.22;2.7.11.23;3.1.3.16;2.3.2.23;4.1.1.17;5.3.1.9;2.7.1.11;2.7.11.21;2.7.11.26;3.1.-.-;1.1.1.205;3.4.22.-;3.6.4.12;3.6.4.6;1.16.3.1;2.7.1.35;2.3.2.5;3.4.24.-;2.7.1.1;5.2.1.8;3.4.19.-;1.11.1.24;5.6.1.5;2.3.2.26;5.4.2.11;5.4.2.4;2.4.2.-;2.4.2.30;3.2.1.23;3.6.1.5;3.6.4.13;3.3.2.6;3.4.19.12;3.5.4.5;4.2.1.24;2.3.2.24;5.4.2.2;3.4.-.-;1.11.2.-;2.4.1.25;3.2.1.33;2.7.1.-;3.5.4.6", "go_molecular_function": "GO:0046872 metal ion binding;GO:0070628 proteasome binding;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "Q9V3H2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3I8-1", "uniprot_id": "OGG1_DROME", "mass": 39406.0, "length": 343, "protein_name": "N-glycosylase/DNA lyase", "gene_name": "Ogg1", "organism": "Fruit fly", "refseq_name": "8-oxoguanine DNA glycosylase", "refseq_ac": "NP_572499", "gene_names_uniprotkb": "Ogg1; CG1795", "gene_names_refseq": "1795; BcDNA:LD19945; CG1795; Dmel\\CG1795; OGG1; Ogg1; dOGG1; dOgg1", "protein_names_uniprotkb": "N-glycosylase/DNA lyase; dOgg1", "protein_names_refseq": "8-oxoguanine DNA glycosylase; CG1795-PA; Ogg1-PA", "tax_id": 7227, "disease": "pterygium (Disease Ontology:DOID:0002116); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); hepatitis (Disease Ontology:DOID:2237); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); basal cell carcinoma (Disease Ontology:DOID:2513); transitional cell carcinoma (Disease Ontology:DOID:2671); angiomyolipoma (Disease Ontology:DOID:3314); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); progressive supranuclear palsy (Disease Ontology:DOID:678); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669)", "pathway": " (dme:Dmel_CG1795); (R-DME-110329); (R-DME-110330); (R-DME-110331); (R-DME-110357)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;10731138;11095666;12537572", "class_list": "", "function": "DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Efficiently incises DNA duplexes containing 8-hydroxyguanine (8-OH-Gua), 8-hydroxyadenine (8-OH-Ade) and abasic (AP) sites placed opposite to a cytosine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.99.18;3.2.2.-", "go_molecular_function": "GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006284 base-excision repair;GO:0034599 cellular response to oxidative stress;GO:0006289 nucleotide-excision repair;GO:0006285 base-excision repair, AP site formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V3I8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3I9-1", "uniprot_id": "Q9V3I9_DROME", "mass": 49515.0, "length": 438, "protein_name": "NOT2/NOT3/NOT5 C-terminal domain-containing protein", "gene_name": "BG:DS07851.5", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_609750", "gene_names_uniprotkb": "BG:DS07851.5; CG15262; Dmel\\CG15262; Dmel_CG15262", "gene_names_refseq": "BG:DS07851.5; CG15262; Dmel\\CG15262", "protein_names_uniprotkb": "NOT2/NOT3/NOT5 C-terminal domain-containing protein", "protein_names_refseq": "CG15262-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15262)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000932 P-body;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:2000036 regulation of stem cell population maintenance;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9V3I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3L6-1", "uniprot_id": "NCBP2_DROME", "mass": 17719.0, "length": 154, "protein_name": "Nuclear cap-binding protein subunit 2", "gene_name": "Cbp20", "organism": "Fruit fly", "refseq_name": "cap binding protein 20", "refseq_ac": "NP_524396", "gene_names_uniprotkb": "Cbp20; CG12357", "gene_names_refseq": "CBP20; CG12357; Cbp20; Dmel\\CG12357; cbp20", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 2; 20 kDa nuclear cap-binding protein; CBP20; NCBP 20 kDa subunit", "protein_names_refseq": "CG12357-PA; Cbp20-PA; cap binding protein 20", "tax_id": 7227, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (dme:Dmel_CG12357); (R-DME-111367); (R-DME-113418); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-674695); (R-DME-6807505); (R-DME-72086); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-73856); (R-DME-77588); (R-DME-77595); (R-DME-975956); (R-DME-975957); (R-DME-9770562); (R-DME-9930044)", "pathway_count": 20, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;19632183", "class_list": "", "function": "Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0045071 negative regulation of viral genome replication;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0030422 siRNA processing;GO:0000398 mRNA splicing, via spliceosome;GO:0031053 primary miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V3L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3N1-1", "uniprot_id": "SP27A_DROME", "mass": 49795.0, "length": 447, "protein_name": "Serine protease inhibitor 27A", "gene_name": "Spn27A", "organism": "Fruit fly", "refseq_name": "serpin 27A, isoform B", "refseq_ac": "NP_001260143", "gene_names_uniprotkb": "Spn27A; CG11331", "gene_names_refseq": "CG11331; Dm-Spn27A; Dmel\\CG11331; EST1; Sp27A; Spn27A; Spn27a; Spn27; sp27A; spn27A", "protein_names_uniprotkb": "Serine protease inhibitor 27A; Serpin 27A", "protein_names_refseq": "CG11331-PB; Dm-serpin-27A; Serpin-27A; Serpin27A; Spn27A-PB; serpin 27A, isoform B; serpin 27A", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); atrial fibrillation (Disease Ontology:DOID:0060224); alpha-2-plasmin inhibitor deficiency (Disease Ontology:DOID:0060601); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Nagashima-type palmoplantar keratosis (Disease Ontology:DOID:0070555); polycystic kidney disease (Disease Ontology:DOID:0080322); COVID-19 (Disease Ontology:DOID:0080600); hereditary angioedema type I (Disease Ontology:DOID:0080939); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); nephritis (Disease Ontology:DOID:10952); meconium aspiration syndrome (Disease Ontology:DOID:11049); hydronephrosis (Disease Ontology:DOID:11111); IgA vasculitis (Disease Ontology:DOID:11123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); familial hyperlipidemia (Disease Ontology:DOID:1168); prediabetes syndrome (Disease Ontology:DOID:11716); nephrotic syndrome (Disease Ontology:DOID:1184); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); uveitis (Disease Ontology:DOID:13141); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); sick sinus syndrome (Disease Ontology:DOID:13884); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); hereditary angioedema (Disease Ontology:DOID:14735); cystic fibrosis (Disease Ontology:DOID:1485); angioedema (Disease Ontology:DOID:1558); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); central retinal vein occlusion (Disease Ontology:DOID:2450); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); antithrombin III deficiency (Disease Ontology:DOID:3755); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); vasculitis (Disease Ontology:DOID:865); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); pulmonary emphysema (Disease Ontology:DOID:9675); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG11331); (R-DME-114608); (R-DME-1650814); (R-DME-209442); (R-DME-381426); (R-DME-6798695); (R-DME-8939242); (R-DME-8957275); (R-DME-9855719); (R-DME-9948001)", "pathway_count": 10, "publication_count": 29, "publication_id_list": "10731132;11296245;11350927;11493599;12408809;12456640;12493753;12537572;12872120;14654000;14667416;14685264;15197269;15749104;15795223;16322759;16399077;16861233;16996061;17324925;18347020;18801354;22227521;24260243;24788090;28604694;40245499;8026333;9533958", "class_list": "", "function": "Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response (PubMed:12408809, PubMed:12456640, PubMed:14654000, PubMed:14667416, PubMed:16322759, PubMed:16861233, PubMed:18801354, PubMed:22227521, PubMed:24260243, PubMed:24788090). Regulates dorsoventral axis formation during early development by inhibiting the serine protease ea/easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo (PubMed:14654000, PubMed:14667416). Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi (PubMed:12408809, PubMed:12456640, PubMed:18801354, PubMed:22227521). Negatively regulates the Hayan-dependent prophenoloxidase 1 (PPO1)-activating cascade in the hemolymph by inhibiting the serine proteases MP1 and Sp7 (PubMed:12408809, PubMed:12456640, PubMed:16322759, PubMed:16861233, PubMed:18801354, PubMed:22227521, PubMed:24260243, PubMed:24788090). May be involved in negatively regulating the melanotic encapsulation around eggs of the parasite L.boulardi (PubMed:12408809, PubMed:15749104)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 102, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0098595 perivitelline space", "go_biological_process": "GO:0048149 behavioral response to ethanol;GO:0050776 regulation of immune response;GO:0009611 response to wounding;GO:0009953 dorsal/ventral pattern formation;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q9V3N1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3U0-1", "uniprot_id": "HMLL_DROME", "mass": 75152.0, "length": 681, "protein_name": "Long-chain-fatty-acid--CoA ligase heimdall", "gene_name": "hll", "organism": "Fruit fly", "refseq_name": "heimdall", "refseq_ac": "NP_609696", "gene_names_uniprotkb": "hll; BG:DS05899.1; CG4500; dbb", "gene_names_refseq": "2a9; BG:DS05899.1; CG4500; Dmel\\CG4500; I; anon-EST:CL2a9; bgm-l; dbb; hll", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase heimdall; 6.2.1.3; Very long-chain-fatty-acid--CoA ligase double bubble", "protein_names_refseq": "CG4500-PA; bubblegum-like; double bubble; doublebubble; heimdall; hll-PA", "tax_id": 7227, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (dme:Dmel_CG4500); (R-DME-75876)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537572;25409104;26893370;29739804", "class_list": "", "function": "Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:26893370, PubMed:29739804). Probably by regulating lipid storage and catabolism, plays a role in neuronal function (PubMed:25409104)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SWR5", "ec_number_list": "6.2.1.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0070050 neuron cellular homeostasis;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep;GO:0070328 triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V3U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V3X4-1", "uniprot_id": "BSCL2_DROME", "mass": 42562.0, "length": 370, "protein_name": "Seipin", "gene_name": "Seipin", "organism": "Fruit fly", "refseq_name": "seipin", "refseq_ac": "NP_570012", "gene_names_uniprotkb": "Seipin; CG9904", "gene_names_refseq": "CG9904; Dmel\\CG9904; EG:BACR7C10.1; Seipin; dSeipin; dmSeipin; seipin", "protein_names_uniprotkb": "Seipin", "protein_names_refseq": "CG9904-PA; Seipin-PA; dSeipin; seipin", "tax_id": 7227, "disease": "congenital generalized lipodystrophy (Disease Ontology:DOID:0050585); autosomal dominant distal hereditary motor neuronopathy 13 (Disease Ontology:DOID:0081401); hereditary spastic paraplegia 17 (Disease Ontology:DOID:0110770); congenital generalized lipodystrophy type 2 (Disease Ontology:DOID:0111136); male infertility (Disease Ontology:DOID:12336); azoospermia (Disease Ontology:DOID:14227); hereditary spastic paraplegia (Disease Ontology:DOID:2476); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (dme:Dmel_CG9904)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10731137;12537569;12537572;21533227;27564575", "class_list": "", "function": "Acts as a tissue-autonomous lipid modulator, preventing ectopic lipid accumulation in salivary gland (a non-adipose tissue) and in promoting lipid storage in fat tissue (PubMed:21533227). Required for the growth and maturation of small nascent lipid droplets (LDs) into larger mature LDs (PubMed:27564575)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0099103 channel activator activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046473 phosphatidic acid metabolic process;GO:0042594 response to starvation;GO:0006874 intracellular calcium ion homeostasis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9V3X4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V429-1", "uniprot_id": "THIO2_DROME", "mass": 11737.0, "length": 106, "protein_name": "Thioredoxin-2", "gene_name": "Trx2", "organism": "Fruit fly", "refseq_name": "thioredoxin 2, isoform A", "refseq_ac": "NP_523526", "gene_names_uniprotkb": "Trx2; CG31884", "gene_names_refseq": "31884; CG31884; CG3864; DTrx-2; DmTrx-2; DmelTrx-2; Dmel\\CG31884; TRX2; Trx-2; Trx2; Trx; anon-WO0118547.188; dmtrx-2; trx-2", "protein_names_uniprotkb": "Thioredoxin-2; DmTrx-2", "protein_names_refseq": "CG31884-PA; Trx2-PA; thioredoxin 2, isoform A; thioredoxin 2; thioredoxin-2", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); glaucoma (Disease Ontology:DOID:1686); myocardial infarction (Disease Ontology:DOID:5844); myocarditis (Disease Ontology:DOID:820); intermediate coronary syndrome (Disease Ontology:DOID:8805); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dme:Dmel_CG31884); (R-DME-2559580); (R-DME-3299685); (R-DME-499943); (R-DME-5628897); (R-DME-5676934); (R-DME-844456)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10731132;11877442;12537569;12537572;15644209", "class_list": "", "function": "Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0H9;D3DMZ9;Q95SW4", "ec_number_list": "", "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0015038 glutathione disulfide oxidoreductase activity;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V429-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V444-1", "uniprot_id": "DPOE3_DROME", "mass": 13844.0, "length": 128, "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "Chrac-14", "organism": "Fruit fly", "refseq_name": "chromatin accessibility complex 14kD protein", "refseq_ac": "NP_476646", "gene_names_uniprotkb": "Chrac-14; CG13399; CHRAC14; CHRAC; DNApolE3; mary", "gene_names_refseq": "13399; 18K protein; 55A11T; CG13399; CG32956; CHRAC-14; CHRAC14; CHRAC; Chrac-14; Chrac14; Dmel\\CG13399; ESTS:55A11T; PolE3; chrac-14; dChrac14; mary", "protein_names_uniprotkb": "DNA polymerase epsilon subunit 3; Chromatin accessibility complex 14kD protein; Histone-fold protein CHRAC subunit", "protein_names_refseq": "CG13399-PB; Chrac-14-PB; DNA polymerase epsilon subunit 3; chromatin accessibility complex 14kD protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13399); (R-DME-110314); (R-DME-5651801); (R-DME-5656169); (R-DME-5696400); (R-DME-6782135); (R-DME-68952); (R-DME-68962)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "10731132;10856248;11447119;12537569;12537572;16260604;18327268;24703848", "class_list": "", "function": "Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes (PubMed:10856248, PubMed:11447119, PubMed:18327268). Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin (PubMed:10856248, PubMed:11447119). As a heterodimer with Chrac-16, binds DNA and facilitates nucleosome sliding by Acf (PubMed:16260604). Has a role in DNA damage response by preventing cid mislocalization to chromatin (PubMed:24703848)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0005634 nucleus;GO:0008623 CHRAC;GO:0140672 ATAC complex", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0006974 DNA damage response;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9V444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V452-1", "uniprot_id": "CHRC_DROME", "mass": 16003.0, "length": 140, "protein_name": "Chromatin accessibility complex 16kD protein", "gene_name": "Chrac-16", "organism": "Fruit fly", "refseq_name": "chromatin accessibility complex 16kD protein, isoform B", "refseq_ac": "NP_001285148", "gene_names_uniprotkb": "Chrac-16; CG15736; CHRAC16; CHRAC; joey", "gene_names_refseq": "15736; 20K protein; BcDNA:RE59557; CG15736; CHRAC-16; CHRAC16; CHRAC; Chrac-16; Chrac16; Dmel\\CG15736; joey", "protein_names_uniprotkb": "Chromatin accessibility complex 16kD protein", "protein_names_refseq": "CG15736-PB; Chrac-16-PB; chromatin accessibility complex 16kD protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15736)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;10856248;11447119;12537569;12537572;16260604;26851213", "class_list": "", "function": "Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes (PubMed:10856248, PubMed:11447119). Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin (PubMed:10856248, PubMed:11447119). As a heterodimer with Chrac-14, binds DNA and facilitates nucleosome sliding by Acf (PubMed:16260604). As part of the CHRAC complex, required for oogenesis (PubMed:26851213)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0046982 protein heterodimerization activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0008623 CHRAC", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9V452-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V461-1", "uniprot_id": "MCM6_DROME", "mass": 92353.0, "length": 817, "protein_name": "DNA replication licensing factor Mcm6", "gene_name": "Mcm6", "organism": "Fruit fly", "refseq_name": "minichromosome maintenance 6", "refseq_ac": "NP_511065", "gene_names_uniprotkb": "Mcm6; CG4039", "gene_names_refseq": "CG4039; DmMCM6; DmeMCM6; Dmel\\CG4039; MCM6; McM6; Mcm6; dMcm6; fs(1)K1214; mcm6", "protein_names_uniprotkb": "DNA replication licensing factor Mcm6; 3.6.4.12; DmMCM6", "protein_names_refseq": "CG4039-PA; Mcm6-PA; female sterile(1)K1214; minichromosome maintenance 6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4039); (R-DME-176187); (R-DME-68867); (R-DME-68949); (R-DME-68962); (R-DME-69052)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10023044;10731132;11854416;12537569;12537572;16798881;20122406;9795205", "class_list": "", "function": "Acts as a component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity Required for DNA replication and cell proliferation. Required for mitotic cycles, endocycles, and the special S phase associated with the amplification of chorion genes; has a role in origin unwinding or fork elongation at chorion loci., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O96047;Q960E3", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;2.7.11.22;2.7.11.23;2.7.7.7;3.1.11.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;2.7.7.-;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0051301 cell division;GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication;GO:1902969 mitotic DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9V461-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V477-1", "uniprot_id": "TOLL8_DROME", "mass": 153305.0, "length": 1346, "protein_name": "Toll-like receptor Tollo", "gene_name": "Tollo", "organism": "Fruit fly", "refseq_name": "tollo", "refseq_ac": "NP_524757", "gene_names_uniprotkb": "Tollo; CG6890; Tl-8; Toll-8", "gene_names_refseq": "CG6890; CT21344; Dmel\\CG6890; TOLL 8; Tl-8; Toll-8; Toll8; Tollo; dTLR8; dToll8; tollo/toll-8; tollo; toll", "protein_names_uniprotkb": "Toll-like receptor Tollo; Toll-like receptor 8", "protein_names_refseq": "CG6890-PA; Toll-8; Tollo-PA; toll receptor; tollo", "tax_id": 7227, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); colitis (Disease Ontology:DOID:0060180); ileitis (Disease Ontology:DOID:0060189); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hymenolepiasis (Disease Ontology:DOID:10074); mastitis (Disease Ontology:DOID:10690); kidney failure (Disease Ontology:DOID:1074); pulpitis (Disease Ontology:DOID:11121); sciatic neuropathy (Disease Ontology:DOID:11446); hepatorenal syndrome (Disease Ontology:DOID:11823); alcoholic hepatitis (Disease Ontology:DOID:12351); carotid stenosis (Disease Ontology:DOID:13001); uveitis (Disease Ontology:DOID:13141); familial combined hyperlipidemia (Disease Ontology:DOID:13809); alcohol use disorder (Disease Ontology:DOID:1574); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); uric acid nephrolithiasis (Disease Ontology:DOID:580); lung disease (Disease Ontology:DOID:850); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG6890)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;10973475;12537572;12588858;12617819;16120803;17078066;17264077;18000549;21158756;22022271;22464169;24662564;25363762;25477468", "class_list": "", "function": "Toll-related receptor (PubMed:10973475). Probably specific to larval innate immunity (PubMed:22022271). Involved in the tracheal immune response of larvae to Gram-negative and perhaps Gram-positive bacteria; upon infection it negatively regulates the immune deficiency (Imd) signaling cascade specifically in the respiratory epithelium to prevent the overexpression of antimicrobial peptides (AMP) (PubMed:22022271). Involved in the NF-kappa-B-dependent apoptosis of unfit cells during cell competition (PubMed:25477468). Involved in neuron-specific glycosylation (PubMed:12588858, PubMed:17264077). Positively controls the neuromuscular junction (NMJ) growth in presynaptic motorneurons, probably via the JNK pathway (PubMed:24662564). During development of the peripheral nervous system, may function in the NF-kappa-B (rel) regulatory cascade to repress expression of the neuron-specific genes sc and ase in non-neuronal cells (PubMed:18000549). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May have a minor role in leg development (PubMed:21158756). May be involved in determining the proximal cell fate in the wing, possibly by negatively regulating the Dpp signaling pathway (PubMed:17078066). May also be involved in the Dpp signaling pathway in the eye (PubMed:17078066). Possibly functions with 18w and Toll-6 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q2XXW0", "ec_number_list": "", "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0045087 innate immune response;GO:0003401 axis elongation;GO:0010559 regulation of glycoprotein biosynthetic process;GO:0048935 peripheral nervous system neuron development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9V477-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V4M2-1", "uniprot_id": "WECH_DROME", "mass": 90573.0, "length": 832, "protein_name": "Protein wech", "gene_name": "wech", "organism": "Fruit fly", "refseq_name": "wech, isoform D", "refseq_ac": "NP_001137614", "gene_names_uniprotkb": "wech; CG42396; dpld", "gene_names_refseq": "CG1624; CG42396; Dmel\\CG42396; Dpld; Wech; dpld; lin-41; wech", "protein_names_uniprotkb": "Protein wech; Protein dappled", "protein_names_refseq": "CG42396-PD; dappled; wech, isoform D; wech-PD", "tax_id": 7227, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (dme:Dmel_CG42396); (R-DME-6798695); (R-DME-983168)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;18327251;18327897;18528333;22438571;8725239", "class_list": "", "function": "Vital for larval development. Plays a role in tumor formation. A crucial component for the physical link between integrins and the cytoskeleton in the epidermal muscle attachment sites., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4IJ45;B7YZS8;Q0E9G5;Q95SY8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0030055 cell-substrate junction", "go_biological_process": "GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0002168 instar larval development;GO:0160175 somatic muscle attachment to chitin-based cuticle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9V4M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V4Q0-1", "uniprot_id": "GL43A_DROME", "mass": 50620.0, "length": 430, "protein_name": "Gustatory receptor-like 43a", "gene_name": "Grl43a", "organism": "Fruit fly", "refseq_name": "gustatory receptor-like 43a", "refseq_ac": "NP_610307", "gene_names_uniprotkb": "Grl43a; CG1339", "gene_names_refseq": "CG1339; Dmel\\CG1339; Gr43b; Grl43a; mdcds_19638", "protein_names_uniprotkb": "Gustatory receptor-like 43a", "protein_names_refseq": "CG1339-PB; Gr43b; Grl43a-PB; gustatory receptor-like 43a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1339)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9V4Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V4T3-1", "uniprot_id": "C4AD1_DROME", "mass": 58871.0, "length": 516, "protein_name": "Probable cytochrome P450 4ad1", "gene_name": "Cyp4ad1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 4ad1, isoform A", "refseq_ac": "NP_610380", "gene_names_uniprotkb": "Cyp4ad1; CG2110", "gene_names_refseq": "4ad1; BEST:LD02646; CG2110; CYP4AD1; Cyp4AD1; Cyp4ad1; Dmel\\CG2110", "protein_names_uniprotkb": "Probable cytochrome P450 4ad1; 1.14.-.-; CYPIVAD1", "protein_names_refseq": "CG2110-PA; CYP4-related; Cyp4ad1-PA; cytochrome P450 4ad1, isoform A; cytochrome P450", "tax_id": 7227, "disease": "aromatase excess syndrome (Disease Ontology:DOID:0090122); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); protein-energy malnutrition (Disease Ontology:DOID:11801); urethral obstruction (Disease Ontology:DOID:12577); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); bladder neck obstruction (Disease Ontology:DOID:13948); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); breast cancer (Disease Ontology:DOID:1612); disorder of sexual development (Disease Ontology:DOID:1923); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); placental insufficiency (Disease Ontology:DOID:3891); esophagus adenocarcinoma (Disease Ontology:DOID:4914); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (dme:Dmel_CG2110); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V4T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V558-1", "uniprot_id": "CP4P1_DROME", "mass": 59433.0, "length": 513, "protein_name": "Cytochrome P450 4p1", "gene_name": "Cyp4p1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 4p1", "refseq_ac": "NP_524828", "gene_names_uniprotkb": "Cyp4p1; CG10842", "gene_names_refseq": "4p1; CG10842; CYP4P1; CYP4p1; Cyp4P1; Cyp4p1; Dmel\\CG10842; P-450; P450; anon-WO0140519.35", "protein_names_uniprotkb": "Cytochrome P450 4p1; 1.14.-.-; CYPIVP1", "protein_names_refseq": "CG10842-PA; Cyp4p1-PA; cytochrome P450 4p1; cytochrome P450-4p1; cytochrome P450", "tax_id": 7227, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); protein-energy malnutrition (Disease Ontology:DOID:11801); hypothyroidism (Disease Ontology:DOID:1459); endometriosis (Disease Ontology:DOID:289); placental insufficiency (Disease Ontology:DOID:3891)", "pathway": " (dme:Dmel_CG10842); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8676871", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24125", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V558-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V564-1", "uniprot_id": "COG6_DROME", "mass": 71206.0, "length": 630, "protein_name": "Conserved oligomeric Golgi complex subunit 6", "gene_name": "Cog6", "organism": "Fruit fly", "refseq_name": "component of oligomeric golgi complex 6, isoform B", "refseq_ac": "NP_610476", "gene_names_uniprotkb": "Cog6; CG1968", "gene_names_refseq": "CG1968; Cog6; Dmel\\CG1968", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 6; COG complex subunit 6; Component of oligomeric Golgi complex 6", "protein_names_refseq": "CG1968-PB; Cog6-PB; component of oligomeric golgi complex 6, isoform B", "tax_id": 7227, "disease": "congenital disorder of glycosylation type IIl (Disease Ontology:DOID:0070264)", "pathway": " (dme:Dmel_CG1968); (R-DME-6807878); (R-DME-6811438); (R-DME-6811440)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Required for normal Golgi function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RW7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0015031 protein transport;GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0007290 spermatid nucleus elongation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V564-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V5C6-1", "uniprot_id": "PSA3_DROME", "mass": 27675.0, "length": 253, "protein_name": "Proteasome subunit alpha type-3", "gene_name": "Prosalpha7", "organism": "Fruit fly", "refseq_name": "proteasome alpha7 subunit", "refseq_ac": "NP_724834", "gene_names_uniprotkb": "Prosalpha7; CG1519", "gene_names_refseq": "1519; Alpha-7; Alpha7; CG1519; CPalpha7; Dmel\\CG1519; PROSalpha7; PSA3_DROME; Pros alpha7; Prosalpha7; alpha-7; alpha7_dm; alpha7; prosalpha7", "protein_names_uniprotkb": "Proteasome subunit alpha type-3; 20S proteasome subunit alpha-7", "protein_names_refseq": "20S proteasome subunit alpha 7; 20S proteasome subunit alpha-7; 20s proteasome; CG1519-PA; Prosalpha7-PA; alpha-subunit of 20S proteasome; alpha7; proteasome alpha7 subunit; proteasome subunit alpha type-3; proteosome alpha7 subunit", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG1519); (R-DME-1169091); (R-DME-1234176); (R-DME-1236974); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9912633); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 58, "publication_count": 37, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537569;12537572;12973300;15178801;15258584;15331761;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17925225;18327897;18519643;18593878;19185492;21529711;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O17313;Q8MKU6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0030707 follicle cell of egg chamber development", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q9V5C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V629-1", "uniprot_id": "CUFF_DROME", "mass": 44833.0, "length": 384, "protein_name": "Protein cutoff", "gene_name": "cuff", "organism": "Fruit fly", "refseq_name": "cutoff", "refseq_ac": "NP_610709", "gene_names_uniprotkb": "cuff; CG13190", "gene_names_refseq": "CG13190; CUFF; Cuff; Dmel\\CG13190; cuff; mel-cuff", "protein_names_uniprotkb": "Protein cutoff", "protein_names_refseq": "CG13190-PA; cuff-PA; cutoff", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13190)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537572;17363252;21952049;24906153;25085419;27292797", "class_list": "", "function": "Involved in the piRNA pathway in germline tissues (PubMed:17363252, PubMed:21952049). Part of the Rhino-Deadlock-Cutoff (RDC) complex that stimulates piRNA biogenesis from chromatin regions corresponding to dual-strand, but not single-stranded, piRNA clusters (PubMed:24906153, PubMed:25085419, PubMed:27292797). Promotes transcription of long piRNA precursors by preventing termination at canonical poly(A) sites (PubMed:27292797). As part of the RDC complex, is recruited to chromatin enriched in histone modification H3K9me3 and might contribute to complex interaction by binding nascent transcript nucleic acid chains (PubMed:24906153, PubMed:25085419, PubMed:27292797). Associates with chromatin upon exposure to homologous piRNA (PubMed:27292797). Suppresses cleavage at canonical poly(A) sites by blocking recruitment of the cleavage and polyadenylation specificity factor (CPSF) complex and prevents transcriptional termination by RNA polymerase II, facilitating transcriptional read-through (PubMed:27292797). As part of the RDC complex, involved in suppression of splicing (PubMed:27292797). Catalytically inactive, lacking 5'-3' exonuclease and pyrophosphohydrolase activities (PubMed:27292797). Stabilizes uncapped piRNA precursors in the nucleus, probably by sequestering or blocking the exonuclease activity of Rat1 (PubMed:27292797). May also be involved in siRNA biogenesis from dual-strand piRNA clusters (PubMed:25085419)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QR5", "ec_number_list": "", "go_molecular_function": "GO:1990470 piRNA cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0030719 P granule organization;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0009953 dorsal/ventral pattern formation;GO:0030422 siRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9V629-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V668-1", "uniprot_id": "S61G1_DROME", "mass": 7564.0, "length": 68, "protein_name": "Protein transport protein Sec61 gamma-1 subunit", "gene_name": "SEC61G1", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_610738", "gene_names_uniprotkb": "SEC61G1; CG8860", "gene_names_refseq": "BcDNA:GM14157; CG8860; Dmel\\CG8860", "protein_names_uniprotkb": "Protein transport protein Sec61 gamma-1 subunit", "protein_names_refseq": "CG8860-PA; uncharacterized protein", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG8860)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Necessary for protein translocation in the endoplasmic reticulum., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005784 Sec61 translocon complex;GO:0071261 Ssh1 translocon complex", "go_biological_process": "GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V668-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V675-1", "uniprot_id": "CP6G2_DROME", "mass": 59608.0, "length": 519, "protein_name": "Probable cytochrome P450 6g2", "gene_name": "Cyp6g2", "organism": "Fruit fly", "refseq_name": "cytochrome P450 6g2", "refseq_ac": "NP_610744", "gene_names_uniprotkb": "Cyp6g2; CG8859", "gene_names_refseq": "6g2; CG8859; Cyp6G2; Cyp6g2; Dmel\\CG8859; cyp6g2", "protein_names_uniprotkb": "Probable cytochrome P450 6g2; 1.14.-.-; CYPVIG2", "protein_names_refseq": "CG8859-PA; Cyp6g2-PA; cytochrome P450 6g2; cytochrome P450", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); alcohol-associated liver disease (Disease Ontology:DOID:0070658); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); essential hypertension (Disease Ontology:DOID:10825); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); familial Mediterranean fever (Disease Ontology:DOID:2987); liver cirrhosis (Disease Ontology:DOID:5082); oral submucous fibrosis (Disease Ontology:DOID:5773); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG8859)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;15663776", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WHF1;Q6SEI3", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0120511 methyl farnesoate epoxidase activity;GO:0120512 farnesoate epoxidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0017085 response to insecticide;GO:0046680 response to DDT;GO:0046701 insecticide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V675-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V6D6-1", "uniprot_id": "CP301_DROME", "mass": 62825.0, "length": 553, "protein_name": "Probable cytochrome P450 301a1, mitochondrial", "gene_name": "Cyp301a1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 301a1", "refseq_ac": "NP_610796", "gene_names_uniprotkb": "Cyp301a1; CG8587", "gene_names_refseq": "301a1; CG8587; Cyp301A1; Cyp301a1; Dmel\\CG8587; cutl", "protein_names_uniprotkb": "Probable cytochrome P450 301a1, mitochondrial; 1.14.-.-; CYPCCCIA1", "protein_names_refseq": "CG8587-PA; Cyp301a1-PA; cytochrome P450 301a1; cytochrome P450", "tax_id": 7227, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); infantile hypercalcemia 1 (Disease Ontology:DOID:0061136); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); gestational diabetes (Disease Ontology:DOID:11714); lung cancer (Disease Ontology:DOID:1324); extrahepatic cholestasis (Disease Ontology:DOID:13619); alcohol use disorder (Disease Ontology:DOID:1574); rectum cancer (Disease Ontology:DOID:1993); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); ovary adenocarcinoma (Disease Ontology:DOID:3713); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cerebrotendinous xanthomatosis (Disease Ontology:DOID:4810); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); lung small cell carcinoma (Disease Ontology:DOID:5409); ulcerative colitis (Disease Ontology:DOID:8577); Wilson disease (Disease Ontology:DOID:893); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG8587)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0007490 tergite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V6D6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V6L9-1", "uniprot_id": "FBSP1_DROME", "mass": 28832.0, "length": 255, "protein_name": "F-box/SPRY domain-containing protein 1", "gene_name": "Fsn", "organism": "Fruit fly", "refseq_name": "F-box synaptic protein, isoform A", "refseq_ac": "NP_610849", "gene_names_uniprotkb": "Fsn; CG4643", "gene_names_refseq": "BEST:GH20696; CG4643; DFsn; Dmel\\CG4643; FBXO2; FSN; Fsn; Wals; dFsn; fsn", "protein_names_uniprotkb": "F-box/SPRY domain-containing protein 1; DFsn", "protein_names_refseq": "CG4643-PA; F-box synaptic protein, isoform A; Fsn-PA; wallenstein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4643)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17697379;20123973;21874015", "class_list": "", "function": "Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ). Negatively regulates the localization of vas to the posterior pole of the oocyte. Involved in primordial germ cell formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7YZR5;Q0E992", "ec_number_list": "", "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0030424 axon;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0010629 negative regulation of gene expression;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9V6L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V6Q2-1", "uniprot_id": "CID_DROME", "mass": 25968.0, "length": 225, "protein_name": "Histone H3-like centromeric protein cid", "gene_name": "cid", "organism": "Fruit fly", "refseq_name": "centromere identifier", "refseq_ac": "NP_523730", "gene_names_uniprotkb": "cid; CENP-A; CG13329", "gene_names_refseq": "BcDNA:RE21270; CENH3; CENP-A/CID; CENP-A/Cid; CENP-A/Cnp1; CENP-A; CENPA; CG13329; CID/CENP-A; CID; CenH3[CID]; CenH3[Cid]; CenH3; Cenp-A; CenpA/CID; CenpA; Cid[Mel]; Cid; Dmel\\CG13329; cenH3; cenp-a; cenpA; cid; dCENP-A; dCenpA", "protein_names_uniprotkb": "Histone H3-like centromeric protein cid; CENP-A homolog; Centromere identifier protein", "protein_names_refseq": "CG13329-PA; centromere identifier protein; centromere identifier; centromere protein A; centromeric histone H3; cid-PA", "tax_id": 7227, "disease": "male infertility (Disease Ontology:DOID:12336); oligospermia (Disease Ontology:DOID:14228); cancer (Disease Ontology:DOID:162); autoimmune disease (Disease Ontology:DOID:417); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG13329)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10639145;10731132;11483958;12537569;12537572;12815450;15475964;15592865;16839185;18327897;21080953;24703848;26586808;31535131", "class_list": "", "function": "Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:11483958, PubMed:16839185). Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (PubMed:11483958, PubMed:16839185, PubMed:24703848). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:11483958, PubMed:16839185)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7YUD4;Q7YUD5;Q8MQP5;Q9NG62", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0051383 kinetochore organization;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9V6Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V751-1", "uniprot_id": "ATTB_DROME", "mass": 22569.0, "length": 218, "protein_name": "Attacin-B", "gene_name": "AttB", "organism": "Fruit fly", "refseq_name": "Attacin-B, isoform B", "refseq_ac": "NP_001163152", "gene_names_uniprotkb": "AttB; AttB1; CG18372", "gene_names_refseq": "Att B; AttB1; AttB2; AttBn; AttB; Attacin B; Attb; Att; CG18372; Dmel\\CG18372; att B1; attB1; attB; attacin b; att", "protein_names_uniprotkb": "Attacin-B", "protein_names_refseq": "AttB-PB; Attacin-B precursor; Attacin-B, isoform B; AttacinB; CG18372-PB; attacin (B); attacin B1; attacin-B; attackin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18372)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10767526;11606542;12537572;16510152", "class_list": "", "function": "Hemolymph antibacterial protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JH67;Q95NV4;Q95U95;Q95U96", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0006959 humoral immune response;GO:0002213 defense response to insect", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V751-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V785-1", "uniprot_id": "3BP5H_DROME", "mass": 53766.0, "length": 477, "protein_name": "SH3 domain-binding protein 5 homolog", "gene_name": "pcs", "organism": "Fruit fly", "refseq_name": "parcas", "refseq_ac": "NP_611010", "gene_names_uniprotkb": "pcs; CG7761", "gene_names_refseq": "CG7761; Dmel\\CG7761; Pcs; pcs; prt", "protein_names_uniprotkb": "SH3 domain-binding protein 5 homolog; Protein parcase", "protein_names_refseq": "CG7761-PB; parcas; parkas; pcs-PB; poirot", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7761)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004860 protein kinase inhibitor activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030292 protein tyrosine kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098548 cytoplasmic side of Golgi membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007517 muscle organ development;GO:0009952 anterior/posterior pattern specification;GO:0048644 muscle organ morphogenesis;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V7P1-1", "uniprot_id": "UTP18_DROME", "mass": 56947.0, "length": 506, "protein_name": "U3 small nucleolar RNA-associated protein 18 homolog", "gene_name": "wcd", "organism": "Fruit fly", "refseq_name": "wicked", "refseq_ac": "NP_611121", "gene_names_uniprotkb": "wcd; CG7989; l(2)k07824", "gene_names_refseq": "CG7989; Dmel\\CG7989; Wcd; l(2)k07824; l(2)kO7824; wcd", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 18 homolog; Protein wicked; WD repeat protein l(2)k07824", "protein_names_refseq": "CG7989-PA; lethal (2) k07824; wcd-PA; wicked", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7989); (R-DME-6791226)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;19430468", "class_list": "", "function": "Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA. Regulation of cell size by ribosome synthesis is an important parameter for stem cell maintenance and function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0034388 Pwp2p-containing subcomplex of 90S preribosome;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0042585 germinal vesicle;GO:0030532 small nuclear ribonucleoprotein complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0007405 neuroblast proliferation;GO:0048132 female germ-line stem cell asymmetric division", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V7P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V7W1-1", "uniprot_id": "PIGV_DROME", "mass": 51544.0, "length": 449, "protein_name": "GPI mannosyltransferase 2", "gene_name": "PIG-V", "organism": "Fruit fly", "refseq_name": "phosphatidylinositol glycan anchor biosynthesis class V, isoform A", "refseq_ac": "NP_001286508", "gene_names_uniprotkb": "PIG-V; CG44239", "gene_names_refseq": "CG44239; CG6657; Dmel\\CG44239; PIG-V; PIGV; gpi-mt2", "protein_names_uniprotkb": "GPI mannosyltransferase 2; 2.4.1.-; GPI mannosyltransferase II; GPI-MT-II", "protein_names_refseq": "CG44239-PA; GPI mannosyltransferase II; PIG-V-PA; phosphatidylinositol glycan anchor biosynthesis class V, isoform A; phosphatidylinositol glycan anchor biosynthesis, class V ortholog; phosphatidylinositol glycan anchor biosynthesis, class V", "tax_id": 7227, "disease": "hyperphosphatasia with impaired intellectual development syndrome 1 (Disease Ontology:DOID:0070433)", "pathway": " (dme:Dmel_CG44239); (R-DME-162710)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;11102367;12537569;12537572;22575127", "class_list": "", "function": "Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Required for the GPI-mediated endoplasmic reticulum exit and proper targeting to the cell surface of chp. Required for GPI-mediated membrane attachment of chp, qsm and Cont. Essential for microvillar stability in the rhabdomere., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LGQ7;B7YZR6;Q0E947;Q95TV6;Q9U3X2", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0120563 dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase activity", "go_cellular_component": "GO:0031501 mannosyltransferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0045313 rhabdomere membrane biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V7W1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V7Y2-1", "uniprot_id": "SGPL_DROME", "mass": 60305.0, "length": 545, "protein_name": "Sphingosine-1-phosphate lyase", "gene_name": "Sply", "organism": "Fruit fly", "refseq_name": "Sphingosine-1-phosphate lyase, isoform A", "refseq_ac": "NP_652032", "gene_names_uniprotkb": "Sply; CG8946; Spl", "gene_names_refseq": "CG8946; Dmel\\CG8946; SPL; Sply; Spl; anon-WO0142479.5; l(2)05091; sply; spl", "protein_names_uniprotkb": "Sphingosine-1-phosphate lyase; 4.1.2.27; S1PL; SP-lyase; SPL; Sphingosine-1-phosphate aldolase", "protein_names_refseq": "CG8946-PA; Sphingosine-1-phosphate lyase, isoform A; Sply-PA; sphinganine-1-phosphate lyase; sphingosine-1-phosphate lyase", "tax_id": 7227, "disease": "RENI syndrome (Disease Ontology:DOID:0080265); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); nephrotic syndrome (Disease Ontology:DOID:1184); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG8946); (R-DME-9845614)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;12702658;28165339", "class_list": "", "function": "Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E946", "ec_number_list": "4.1.2.27", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008117 sphinganine-1-phosphate aldolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0019752 carboxylic acid metabolic process;GO:0007527 adult somatic muscle development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V7Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V8M2-1", "uniprot_id": "C12B2_DROME", "mass": 61477.0, "length": 535, "protein_name": "Probable cytochrome P450 12b2, mitochondrial", "gene_name": "Cyp12b2", "organism": "Fruit fly", "refseq_name": "cytochrome P450 12b2", "refseq_ac": "NP_611370", "gene_names_uniprotkb": "Cyp12b2; CG15077", "gene_names_refseq": "12b2; CG15077; Cyp12B2; Cyp12b2; Dmel\\CG15077", "protein_names_uniprotkb": "Probable cytochrome P450 12b2, mitochondrial; 1.14.-.-; CYPXIIB2", "protein_names_refseq": "CG15077-PA; Cyp12b2-PA; cytochrome P450 12b2", "tax_id": 7227, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); infantile hypercalcemia 1 (Disease Ontology:DOID:0061136); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); gestational diabetes (Disease Ontology:DOID:11714); lung cancer (Disease Ontology:DOID:1324); extrahepatic cholestasis (Disease Ontology:DOID:13619); alcohol use disorder (Disease Ontology:DOID:1574); rectum cancer (Disease Ontology:DOID:1993); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); ovary adenocarcinoma (Disease Ontology:DOID:3713); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cerebrotendinous xanthomatosis (Disease Ontology:DOID:4810); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); lung small cell carcinoma (Disease Ontology:DOID:5409); ulcerative colitis (Disease Ontology:DOID:8577); Wilson disease (Disease Ontology:DOID:893); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG15077)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V474", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0031966 mitochondrial membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9V8M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V9P3-1", "uniprot_id": "TI50A_DROME", "mass": 40580.0, "length": 343, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM50-A", "gene_name": "ttm3", "organism": "Fruit fly", "refseq_name": "tiny tim 3", "refseq_ac": "NP_610130", "gene_names_uniprotkb": "ttm3; CG6691", "gene_names_refseq": "CG6691; Dmel\\CG6691; ttm3", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM50-A; Tiny tim 3", "protein_names_refseq": "CG6691-PA; tiny tim 3; ttm3-PA", "tax_id": 7227, "disease": "3-methylglutaconic aciduria type 9 (Disease Ontology:DOID:0070002)", "pathway": " (dme:Dmel_CG6691)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;17435247", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QPP6", "ec_number_list": "", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0006470 protein dephosphorylation;GO:0007005 mitochondrion organization;GO:0030150 protein import into mitochondrial matrix;GO:0007006 mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V9P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V9U4-1", "uniprot_id": "DOHH_DROME", "mass": 33564.0, "length": 302, "protein_name": "Deoxyhypusine hydroxylase", "gene_name": "nero", "organism": "Fruit fly", "refseq_name": "nero", "refseq_ac": "NP_651887", "gene_names_uniprotkb": "nero; CG2245; l(3)s1921", "gene_names_refseq": "CG2245; DOHH; Dmel\\CG2245; l(3)s1921; nero", "protein_names_uniprotkb": "Deoxyhypusine hydroxylase; 1.14.99.29; DOHH; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase", "protein_names_refseq": "CG2245-PA; deoxyhypusine hydroxylase; lethal (3) s1921; nero-PA; nero", "tax_id": 7227, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dme:Dmel_CG2245); (R-DME-204626)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10471706;10731132;12537569;12537572;19546244", "class_list": "", "function": "Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor (By similarity). Essential for organismal viability and plays a role in a wide number of important processes such as cell growth and proliferation, and regulates induction of autophagy and protein synthesis. Has a role in eIF-5A-mediated translational control., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.99.29", "go_molecular_function": "GO:0019135 deoxyhypusine monooxygenase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0042406 extrinsic component of endoplasmic reticulum membrane", "go_biological_process": "GO:0008612 peptidyl-lysine modification to peptidyl-hypusine", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V9U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9V9Z1-1", "uniprot_id": "RM32_DROME", "mass": 22642.0, "length": 195, "protein_name": "Large ribosomal subunit protein bL32m", "gene_name": "mRpL32", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L32", "refseq_ac": "NP_524606", "gene_names_uniprotkb": "mRpL32; CG12220", "gene_names_refseq": "BcDNA:LD41522; CG12220; Dmel\\CG12220; L32; Mrpl32; mRpL32", "protein_names_uniprotkb": "Large ribosomal subunit protein bL32m; 39S ribosomal protein L32, mitochondrial; L32mt; MRP-L32", "protein_names_refseq": "CG12220-PA; mRpL32-PA; mitochondrial ribosomal protein L32", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12220); (R-DME-5389840); (R-DME-5419276); (R-DME-9837999); (R-DME-9937383)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Component of the mitochondrial large ribosomal subunit (mt-LSU). The mitochondrial ribosome (mitoribosome) is a large ribonucleoprotein complex responsible for the synthesis of proteins inside mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V9Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VA00-1", "uniprot_id": "ZWILC_DROME", "mass": 72442.0, "length": 641, "protein_name": "Protein zwilch", "gene_name": "Zwilch", "organism": "Fruit fly", "refseq_name": "zwilch", "refseq_ac": "NP_733421", "gene_names_uniprotkb": "Zwilch; CG18729", "gene_names_refseq": "CG18639; CG18729; Dmel\\CG18729; Zwilch; zwilch", "protein_names_uniprotkb": "Protein zwilch", "protein_names_refseq": "CG18729-PA; Zwilch-PA; zwilch", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18729)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;12686595;15886105;17372656;17576797;22685323", "class_list": "", "function": "Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:15886105, PubMed:17576797). Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores (PubMed:15886105, PubMed:17576797). Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex (PubMed:22685323). Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments (PubMed:22685323)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95TU6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:1990423 RZZ complex;GO:0005737 cytoplasm;GO:0051233 spindle midzone;GO:0000776 kinetochore", "go_biological_process": "GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0051988 regulation of attachment of spindle microtubules to kinetochore;GO:0034501 protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VA00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VA12-1", "uniprot_id": "PSA4L_DROME", "mass": 28169.0, "length": 251, "protein_name": "Proteasome subunit alpha type-4-like", "gene_name": "Prosalpha3T", "organism": "Fruit fly", "refseq_name": "proteasome alpha3 subunit, Testis-specific", "refseq_ac": "NP_651843", "gene_names_uniprotkb": "Prosalpha3T; CG1736", "gene_names_refseq": "CG1736; Dmel\\CG1736; Pros20S-alpha3t; Prosalpha3T; alpha3T; prosalpha3T", "protein_names_uniprotkb": "Proteasome subunit alpha type-4-like", "protein_names_refseq": "20s proteasome; CG1736-PA; Prosalpha3T-PA; proteasome 20S alpha3t subunit; proteasome alpha3 subunit, Testis-specific; proteasome alpha3T subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1736)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12421421;12537572", "class_list": "", "function": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DN24;Q8IS89", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0001673 male germ cell nucleus;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VA12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VA27-1", "uniprot_id": "CP4C3_DROME", "mass": 60757.0, "length": 535, "protein_name": "Cytochrome P450 4c3", "gene_name": "Cyp4c3", "organism": "Fruit fly", "refseq_name": "cytochrome P450 4c3", "refseq_ac": "NP_524598", "gene_names_uniprotkb": "Cyp4c3; CG1438", "gene_names_refseq": "4C3; CG1438; Cyp4c3; Dmel\\CG1438; P-450; P450; cyp4c3", "protein_names_uniprotkb": "Cytochrome P450 4c3; 1.14.-.-; CYPIVC3", "protein_names_refseq": "CG1438-PA; Cyp4c3-PA; cytochrome P450 4c3; cytochrome P450-4c3; cytochrome P450", "tax_id": 7227, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664)", "pathway": " (dme:Dmel_CG1438); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976); (R-DME-2453902)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10731132;12537572;8676871", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24121", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VA27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VA37-1", "uniprot_id": "DJ1B_DROME", "mass": 19250.0, "length": 187, "protein_name": "Protein dj-1beta", "gene_name": "dj-1beta", "organism": "Fruit fly", "refseq_name": "dj-1beta", "refseq_ac": "NP_651825", "gene_names_uniprotkb": "dj-1beta; CG1349; dj-1-beta", "gene_names_refseq": "CG1349; DJ-1 beta; DJ-1B; DJ-1beta; DJ-1b; DJ-1; DJ1-1beta; Dj-1beta; Dmel\\CG1349; dDJ-1beta; dj-1beta; dj-1b; dj1-beta", "protein_names_uniprotkb": "Protein dj-1beta", "protein_names_refseq": "CG1349-PB; DJ-1B; dj-1beta-PB; dj-1beta", "tax_id": 7227, "disease": "Parkinson's disease 7 (Disease Ontology:DOID:0060370); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinsonism (Disease Ontology:DOID:0080855); Parkinson's disease (Disease Ontology:DOID:14330); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG1349)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537569;12537572;15976810;16139213;16139214;16203113;16894167;20457924;22515803;23593018;27903648;30540251", "class_list": "", "function": "Plays an important role in cell protection against oxidative stress and cell death by acting as a oxidative stress sensor (PubMed:16139214, PubMed:16203113, PubMed:16894167, PubMed:20457924). Does not play a role in methylglyoxal detoxification (PubMed:27903648). Plays a role in mitochondrial function together with Pink1 (PubMed:20457924). In motor neurons regulates structural synaptic plasticity of locomotor behavior as part of the PTEN-phosphatidylinositol 3-kinase pathway in response to oxygen species (ROS) levels (PubMed:30540251)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KXK5;Q95SP6", "ec_number_list": "", "go_molecular_function": "GO:0051920 peroxiredoxin activity;GO:0036524 protein deglycase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008344 adult locomotory behavior;GO:0048167 regulation of synaptic plasticity;GO:0034614 cellular response to reactive oxygen species;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VA37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAF7-1", "uniprot_id": "PR99C_DROME", "mass": 23554.0, "length": 201, "protein_name": "Protamine-like protein 99C", "gene_name": "Prtl99C", "organism": "Fruit fly", "refseq_name": "Protamine-like 99C, isoform C", "refseq_ac": "NP_001163771", "gene_names_uniprotkb": "Prtl99C; CG15510", "gene_names_refseq": "BcDNA:AT14346; CG15510; Dmel\\CG15510; Prtl99C", "protein_names_uniprotkb": "Protamine-like protein 99C", "protein_names_refseq": "CG15510-PC; Protamine-like 99C, isoform C; Prtl99C-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15510)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;26673329", "class_list": "", "function": "Regulates chromatin compaction in spermatid nuclei and is essential for male fertility. Functions in parallel with other chromatin-condensing proteins such as ProtA, ProtB and Mst77F., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JJ16;F2FB58;Q8MZC5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0030261 chromosome condensation;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VAF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAH4-1", "uniprot_id": "PTC71_DROME", "mass": 34838.0, "length": 314, "protein_name": "Protein phosphatase PTC7 homolog fig", "gene_name": "fig", "organism": "Fruit fly", "refseq_name": "fos intronic gene", "refseq_ac": "NP_651724", "gene_names_uniprotkb": "fig; CG7615", "gene_names_refseq": "CG7615; Dmel\\CG7615; PPTC7; fig", "protein_names_uniprotkb": "Protein phosphatase PTC7 homolog fig; 3.1.3.16; Fos intronic gene protein", "protein_names_refseq": "CG7615-PA; fig-PA; fos intron gene; fos intronic gene; fos-intronic gene", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7615)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18571877", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8MPH7;Q8SWZ0", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.27;3.1.3.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010795 regulation of ubiquinone biosynthetic process;GO:1904775 positive regulation of ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VAH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAI1-1", "uniprot_id": "CIA30_DROME", "mass": 34206.0, "length": 296, "protein_name": "Complex I intermediate-associated protein 30, mitochondrial", "gene_name": "NdufAF1", "organism": "Fruit fly", "refseq_name": "complex I intermediate-associated protein, 30 kDa", "refseq_ac": "NP_651718", "gene_names_uniprotkb": "NdufAF1; CG7598; CIA30", "gene_names_refseq": "CG7598; CI30; CIA30; Dmel\\CG7598; dCI-30; dCIA30; dNDUFAF1", "protein_names_uniprotkb": "Complex I intermediate-associated protein 30, mitochondrial; NADH:ubiquinone oxidoreductase complex assembly factor 1", "protein_names_refseq": "CG7598-PA; CIA30-PA; complex I intermediate- associate protein 30; complex I intermediate-associated protein 30; complex I intermediate-associated protein, 30 kDa", "tax_id": 7227, "disease": "nuclear type mitochondrial complex I deficiency 11 (Disease Ontology:DOID:0112089); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG7598); (R-DME-6799198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;23226344;34386730", "class_list": "", "function": "Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T3R5", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0160295 mitochondrial complex I intermediate assembly complex", "go_biological_process": "GO:0042594 response to starvation;GO:0001666 response to hypoxia;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VAI1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAL0-1", "uniprot_id": "SPCS1_DROME", "mass": 11059.0, "length": 98, "protein_name": "Signal peptidase complex subunit 1", "gene_name": "Spase12", "organism": "Fruit fly", "refseq_name": "spase 12-subunit", "refseq_ac": "NP_788760", "gene_names_uniprotkb": "Spase12; CG11500", "gene_names_refseq": "CG11500; CG31042; Dmel\\CG11500; Spase12; spase12", "protein_names_uniprotkb": "Signal peptidase complex subunit 1; Microsomal signal peptidase 12 kDa subunit; SPase 12 kDa subunit", "protein_names_refseq": "CG11500-PA; Spase12-PA; spase 12-subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11500)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;15901661;18327897;27383988", "class_list": "", "function": "(Microbial infection) Plays an important role in infection by flaviviruses such as West Nile virus and Dengue virus type 2., [UniProtKB, PubMed]; Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VAL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAN0-1", "uniprot_id": "SERC_DROME", "mass": 39540.0, "length": 364, "protein_name": "Phosphoserine aminotransferase", "gene_name": "Psat", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_652046", "gene_names_uniprotkb": "Psat; CG11899", "gene_names_refseq": "39C10S; CG11899; Dmel\\CG11899; ESTS:39C10S; Ov8; anon-sts29", "protein_names_uniprotkb": "Phosphoserine aminotransferase; 2.6.1.52; Phosphohydroxythreonine aminotransferase", "protein_names_refseq": "CG11899-PA; uncharacterized protein", "tax_id": 7227, "disease": "PSAT deficiency (Disease Ontology:DOID:0050723); Neu-Laxova syndrome 2 (Disease Ontology:DOID:0080075)", "pathway": " (dme:Dmel_CG11899); (R-DME-977347)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15917496", "class_list": "", "function": "Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3YMT6", "ec_number_list": "2.6.1.52", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006564 L-serine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VAN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAN6-1", "uniprot_id": "SLBP_DROME", "mass": 30624.0, "length": 276, "protein_name": "Histone RNA hairpin-binding protein", "gene_name": "Slbp", "organism": "Fruit fly", "refseq_name": "Stem-loop binding protein", "refseq_ac": "NP_477480", "gene_names_uniprotkb": "Slbp; CG11886", "gene_names_refseq": "CG11886; Dmel\\CG11886; SLBP; Slbp; dSLBP; dSLPB; slbp", "protein_names_uniprotkb": "Histone RNA hairpin-binding protein; Histone stem-loop-binding protein", "protein_names_refseq": "CG11886-PA; Slbp-PA; Stem-loop binding protein; stem loop binding protein; stem-loop-binding protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11886); (R-DME-159230); (R-DME-73856); (R-DME-77588)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10731132;11157774;12537569;12537572;14999087;18327897;19450530", "class_list": "", "function": "Involved in histone pre-mRNA 3' processing and couples histone mRNA production with the cell cycle. Both maternal and zygotic proteins play an essential and vital function for development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9GU71", "ec_number_list": "", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0071207 histone pre-mRNA stem-loop binding;GO:0003729 mRNA binding;GO:0035613 RNA stem-loop binding", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007076 mitotic chromosome condensation;GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VAN6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAN8-1", "uniprot_id": "Q9VAN8_DROME", "mass": 29698.0, "length": 263, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG11882", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001263056", "gene_names_uniprotkb": "Dmel\\CG11882; CG11882; Dmel_CG11882", "gene_names_refseq": "CG11882; Dmel\\CG11882", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG11882-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11882)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VAN8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAQ1-1", "uniprot_id": "SIR7_DROME", "mass": 88469.0, "length": 771, "protein_name": "NAD-dependent protein deacetylase Sirt7", "gene_name": "Sirt7", "organism": "Fruit fly", "refseq_name": "sirtuin 7", "refseq_ac": "NP_651664", "gene_names_uniprotkb": "Sirt7; CG11305", "gene_names_refseq": "CG11305; D.mel5; Dmel\\CG11305; SIRT7; Sirt7; dSIRT7; dmSRT409", "protein_names_uniprotkb": "NAD-dependent protein deacetylase Sirt7; 2.3.1.286; Regulatory protein SIR2 homolog 7; SIR2-like protein 7", "protein_names_refseq": "CG11305-PA; Sirt7-PA; sirtuin 7", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11305)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;18327897", "class_list": "", "function": "NAD-dependent protein deacetylase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.286", "go_molecular_function": "GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0097372 histone H3K18 deacetylase activity, NAD-dependent;GO:0046872 metal ion binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:0010468 regulation of gene expression;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VAQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VAU9-1", "uniprot_id": "ZN330_DROME", "mass": 35355.0, "length": 315, "protein_name": "Zinc finger protein 330 homolog", "gene_name": "Noa36", "organism": "Fruit fly", "refseq_name": "Noa36", "refseq_ac": "NP_651622", "gene_names_uniprotkb": "Noa36; CG10009", "gene_names_refseq": "CG10009; Dmel\\CG10009; NOA 36; NOA36; Noa36; noa36", "protein_names_uniprotkb": "Zinc finger protein 330 homolog; Nucleolar autoantigen 36 homolog", "protein_names_refseq": "CG10009-PA; Noa36-PA; Noa36", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10009)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10593942;10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97181", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region;GO:0030496 midbody", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VAU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VB08-1", "uniprot_id": "RING1_DROME", "mass": 47256.0, "length": 435, "protein_name": "E3 ubiquitin-protein ligase RING1", "gene_name": "Sce", "organism": "Fruit fly", "refseq_name": "Sex combs extra", "refseq_ac": "NP_477509", "gene_names_uniprotkb": "Sce; CG5595", "gene_names_refseq": "CG5595; DRING; Ding; Dmel\\CG5595; Dring; RING/Sce; RING1; RING; Ring/Sce; Ring; Rnf2; SCE; Sce/dRing; Sce; See/dRing; dRING1; dRING; dRNIG; dRing1; dRing; dring; sce", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING1; 2.3.2.27; RING-type E3 ubiquitin transferase RING1; Sex comb extra protein; dRING protein; dRING1", "protein_names_refseq": "CG5595-PA; SCE/dRING; Sce-PA; Sex comb extra; Sex combs extra; dRING1; ring", "tax_id": 7227, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); developmental disorder of mental health (Disease Ontology:DOID:0060037); Luo-Schoch-Yamamoto syndrome (Disease Ontology:DOID:0070416); spina bifida (Disease Ontology:DOID:0080016); cancer (Disease Ontology:DOID:162); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (dme:Dmel_CG5595); (R-DME-2559580); (R-DME-3108214); (R-DME-3899300); (R-DME-4570464); (R-DME-8939243); (R-DME-8943724); (R-DME-8953750)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "10731132;11493925;11583617;12537569;12537572;12963114;14669021;14967148;15147763;15386022;15567868;18327897", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-118' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-118' ubiquitination gives a specific tag for epigenetic transcriptional repression. Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. PcG complexes act via modification of histones, such as methylation, deacetylation, ubiquitination rendering chromatin heritably changed in its expressibility. May play a role in meiotic sister chromatid cohesion., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18380", "ec_number_list": "2.1.1.356;2.1.1.367;2.1.1.371;2.1.1.355;2.1.1.369;2.1.1.368;2.7.11.24;2.7.11.1;2.3.2.27", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VB08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VB14-1", "uniprot_id": "RS10A_DROME", "mass": 18231.0, "length": 163, "protein_name": "Small ribosomal subunit protein eS10A", "gene_name": "RpS10a", "organism": "Fruit fly", "refseq_name": "ribosomal protein S10a", "refseq_ac": "NP_651576", "gene_names_uniprotkb": "RpS10a; CG12275; RpS10", "gene_names_refseq": "BcDNA:LD32148; CG12275; Dmel\\CG12275; RpS10a; RpS10; S10e; S10", "protein_names_uniprotkb": "Small ribosomal subunit protein eS10A; 40S ribosomal protein S10a", "protein_names_refseq": "CG12275-PA; RpS10a-PA; ribosomal protein S10a", "tax_id": 7227, "disease": "Diamond-Blackfan anemia 9 (Disease Ontology:DOID:0111884)", "pathway": " (dme:Dmel_CG12275)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731138;12537572;23636399", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Y0Y3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VB14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VB22-1", "uniprot_id": "Q9VB22_DROME", "mass": 71469.0, "length": 658, "protein_name": "Partner of inscuteable", "gene_name": "pins", "organism": "Fruit fly", "refseq_name": "partner of inscuteable", "refseq_ac": "NP_524999", "gene_names_uniprotkb": "pins; CG5692; Dmel\\CG5692; Dmel_CG5692; LGN; PINS; Pins; RAPS; Rad; Raps; dLGN; dPins; rad; rapsyn; raps", "gene_names_refseq": "CG5692; Dmel\\CG5692; LGN; PINS; Pins; RAPS; Rad; Raps; dLGN; dPins; pins/raps; pins; rad; rapsyn; raps", "protein_names_uniprotkb": "Partner of inscuteable", "protein_names_refseq": "CG5692-PA; partner of inscutable; partner of inscuteable; pins-PA; rapsinoid; rapsynoid", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); sensorineural hearing loss (Disease Ontology:DOID:10003); brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG5692); (R-DME-418594)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;22171003;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0001965 G-protein alpha-subunit binding;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:1990499 raps-insc complex", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0000132 establishment of mitotic spindle orientation;GO:0007405 neuroblast proliferation;GO:0008356 asymmetric cell division;GO:0055059 asymmetric neuroblast division", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VB22-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VB74-1", "uniprot_id": "NKAP_DROME", "mass": 52948.0, "length": 463, "protein_name": "NF-kappa-B-activating protein", "gene_name": "Nkap", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_651538", "gene_names_uniprotkb": "Nkap; CG6066", "gene_names_refseq": "CG6066; Dmel\\CG6066; NFkb", "protein_names_uniprotkb": "NF-kappa-B-activating protein; NFKB activating protein; dNKAP", "protein_names_refseq": "CG6066-PA; uncharacterized protein", "tax_id": 7227, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); carcinoma (Disease Ontology:DOID:305)", "pathway": " (dme:Dmel_CG6066); (R-DME-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537572;17372656;18327897;38059855", "class_list": "", "function": "Tumor suppressor involved in maintaining genome integrity (PubMed:38059855). Influences gene expression and mRNA splicing (PubMed:38059855)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86P49", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0010468 regulation of gene expression;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VB74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VBU8-1", "uniprot_id": "NUP37_DROME", "mass": 35350.0, "length": 320, "protein_name": "Nucleoporin Nup37", "gene_name": "Nup37", "organism": "Fruit fly", "refseq_name": "nucleoporin 37kD, isoform B", "refseq_ac": "NP_001262950", "gene_names_uniprotkb": "Nup37; CG11875", "gene_names_refseq": "CG11875; Dmel\\CG11875; Nup37; nup37", "protein_names_uniprotkb": "Nucleoporin Nup37; 37 kDa nucleoporin", "protein_names_refseq": "CG11875-PB; Nup37-PB; nucleoporin 37kD, isoform B", "tax_id": 7227, "disease": "primary autosomal recessive microcephaly 24 (Disease Ontology:DOID:0051035)", "pathway": " (dme:Dmel_CG11875); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 3, "publication_id_list": "10731132;12537572;22851751", "class_list": "", "function": "(Microbial infection) Required for optimal replication of E.chaffeensis., [UniProtKB, PubMed]; As part of the nuclear pore complex (NPC), has a role in its assembly and function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VBU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VBW3-1", "uniprot_id": "CAD96_DROME", "mass": 86220.0, "length": 773, "protein_name": "Tyrosine kinase receptor Cad96Ca", "gene_name": "Cad96Ca", "organism": "Fruit fly", "refseq_name": "cadherin 96Ca", "refseq_ac": "NP_651349", "gene_names_uniprotkb": "Cad96Ca; CG10244; HD-14", "gene_names_refseq": "CG10239; CG10244; CT28779; Cad 96Ca; Cad96Ca; Cad96C; DCad96Ca; Dm Cad96Ca; DmHD-14; Dmel\\CG10244; FGFR1-like; HD-14; cad96Ca; cad96C; stit", "protein_names_uniprotkb": "Tyrosine kinase receptor Cad96Ca; 2.7.10.1; Cadherin-96Ca; Tyrosine kinase receptor HD-14", "protein_names_refseq": "CG10244-PA; Cad96Ca-PA; cadherin 96Ca; stitcher", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10244)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9731193", "class_list": "", "function": "", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O18368;Q8SZC9;Q9VBW2", "ec_number_list": "2.7.10.1;2.7.10.2;2.7.12.1;2.7.12.2;2.7.11.22;2.7.11.1", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045177 apical part of cell", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0090303 positive regulation of wound healing;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VBW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VC49-1", "uniprot_id": "RPAB5_DROME", "mass": 7661.0, "length": 67, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "gene_name": "Polr2L", "organism": "Fruit fly", "refseq_name": "RNA polymerase II, I and III subunit L", "refseq_ac": "NP_651280", "gene_names_uniprotkb": "Polr2L; CG13628; Rpb10", "gene_names_refseq": "BcDNA:SD08670; CG13628; Dmel\\CG13628; Polr2L; RPB10; Rpb10", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC5; RNA polymerase II, I and III subunit L; RNA polymerases I, II, and III subunit ABC5; RPB10 homolog", "protein_names_refseq": "CG13628-PA; Polr2L-PA; RNA polymerase II, I and III subunit L; Rpb10", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13628); (R-DME-112382); (R-DME-113418); (R-DME-5578749); (R-DME-674695); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6796648); (R-DME-6807505); (R-DME-72086); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-73762); (R-DME-73772); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-75955); (R-DME-76042); (R-DME-76061); (R-DME-76066); (R-DME-77075); (R-DME-9018519); (R-DME-9770562)", "pathway_count": 26, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, Polr2L is part of the core element with the central large cleft (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VC49-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCB1-1", "uniprot_id": "PTOV1_DROME", "mass": 40510.0, "length": 364, "protein_name": "Protein PTOV1 homolog", "gene_name": "CG13609", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_651233", "gene_names_uniprotkb": "CG13609", "gene_names_refseq": "CG13609; Dmel\\CG13609", "protein_names_uniprotkb": "Protein PTOV1 homolog", "protein_names_refseq": "CG13609-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13609)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005667 transcription regulator complex;GO:0016592 mediator complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VCB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCC0-1", "uniprot_id": "CHRD1_DROME", "mass": 40240.0, "length": 354, "protein_name": "Cysteine and histidine-rich domain-containing protein morgana", "gene_name": "mora", "organism": "Fruit fly", "refseq_name": "morgana", "refseq_ac": "NP_651226", "gene_names_uniprotkb": "mora; CG6198; CHORD", "gene_names_refseq": "CG6198; CHORD; Chord; Dmel\\CG6198; Q9U4A3; chp; dCHORDC1; mora", "protein_names_uniprotkb": "Cysteine and histidine-rich domain-containing protein morgana", "protein_names_refseq": "CG6198-PA; CHORD containing protein; mora-PA; morgana/chp-1; morgana", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6198)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10571178;10731132;12537569;12537572;17372656;18327897;20230755;24643112;31907206", "class_list": "", "function": "Regulates centrosome duplication and mitotic spindle dynamics (PubMed:20230755, PubMed:31907206). Also involved in controlling the size of dendritic arbors (PubMed:24643112). May act as co-chaperone for Hsp83 (PubMed:31907206). During mitotic spindle assembly, regulates microtubule (MT) dynamics by binding to MTs and promoting MT polymerization (PubMed:31907206). Promotes the elongation and retraction of terminal branches in response to changes in body size, possibly acting downstream of the TORC2 pathway to enable proportional scaling of dendritic arbors (PubMed:24643112)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9U4A3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0031116 positive regulation of microtubule polymerization;GO:0051298 centrosome duplication;GO:1901673 regulation of mitotic spindle assembly;GO:0050773 regulation of dendrite development;GO:0008361 regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VCC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCC3-1", "uniprot_id": "RT24_DROME", "mass": 19252.0, "length": 165, "protein_name": "Small ribosomal subunit protein uS3m", "gene_name": "mRpS24", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein S24", "refseq_ac": "NP_524476", "gene_names_uniprotkb": "mRpS24; CG13608", "gene_names_refseq": "CG13608; Dmel\\CG13608; MRP-S24; MrpS24; mRpS24", "protein_names_uniprotkb": "Small ribosomal subunit protein uS3m; 28S ribosomal protein S24, mitochondrial; MRP-S24; S24mt", "protein_names_refseq": "CG13608-PA; mRpS24-PA; mitochondrial ribosomal protein S24", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13608); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VCC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCE1-1", "uniprot_id": "BECN1_DROME", "mass": 48870.0, "length": 422, "protein_name": "Beclin-1-like protein", "gene_name": "Atg6", "organism": "Fruit fly", "refseq_name": "Autophagy-related 6", "refseq_ac": "NP_651209", "gene_names_uniprotkb": "Atg6; CG5429", "gene_names_refseq": "ATG6; Atg6; BECN1; Beclin-1; Beclin1; CG5429; DmAtg6; Dmel\\CG5429; atg6; beclin; dAtg6; l(3)00096", "protein_names_uniprotkb": "Beclin-1-like protein; APG6-like; Autophagy protein 6-like", "protein_names_refseq": "Atg6-PA; Autophagy-related 6; Autophagy-specific gene 6; Beclin-1; Beclin1; CG5429-PA; beclin 1", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); polycystic kidney disease (Disease Ontology:DOID:0080322); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); glioblastoma (Disease Ontology:DOID:3068); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); viral encephalitis (Disease Ontology:DOID:646); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dme:Dmel_CG5429); (R-DME-1632852); (R-DME-5689880)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;32248620", "class_list": "", "function": "Plays a central role in autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 39, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0000407 phagophore assembly site;GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I;GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0000045 autophagosome assembly;GO:0006897 endocytosis;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VCE1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCE6-1", "uniprot_id": "MTA70_DROME", "mass": 68101.0, "length": 608, "protein_name": "N(6)-adenosine-methyltransferase MT-A70-like protein", "gene_name": "Mettl3", "organism": "Fruit fly", "refseq_name": "methyltransferase like 3", "refseq_ac": "NP_651204", "gene_names_uniprotkb": "Mettl3; CG5933; Ime4", "gene_names_refseq": "CG5933; Dm ime4; Dmel\\CG5933; IME4; Ime4; METTL3; MTA70; Mettl3; Mta70; dIME4; ime4; mettl3", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase MT-A70-like protein; 2.1.1.348; Inducer of meiosis 4; Methyltransferase-like 3", "protein_names_refseq": "CG5933-PA; Mettl3-PA; Mta70 homologue; inducer of MEiosis 4 homolog; inducer of meiosis 4; methyltransferase like 3", "tax_id": 7227, "disease": "infertility (Disease Ontology:DOID:5223)", "pathway": " (dme:Dmel_CG5933); (R-DME-72203)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;21873203;27919077;27919081;28675155;29535189;29555755", "class_list": "", "function": "Catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:27919081, PubMed:28675155). In the heterodimer formed with Mettl14, constitutes the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:27919077, PubMed:27919081, PubMed:28675155). M6A methylation is also required for neuronal functions (PubMed:27919077). During oogenesis, required for egg chamber development probably as part of the N/Notch signaling (PubMed:21873203)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.6;2.1.1.348", "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus", "go_biological_process": "GO:0007530 sex determination;GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:0008380 RNA splicing;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VCE6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCI0-1", "uniprot_id": "ORN_DROME", "mass": 24298.0, "length": 211, "protein_name": "RNA exonuclease 2", "gene_name": "Rex2", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_651184", "gene_names_uniprotkb": "Rex2; CG10214", "gene_names_refseq": "CG10214; Dmel\\CG10214; Rex2", "protein_names_uniprotkb": "RNA exonuclease 2; 3.1.15.-", "protein_names_refseq": "CG10214-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10214)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "3'-to-5' exoribonuclease specific for small oligoribonucleotides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008408 3'-5' exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCI5-1", "uniprot_id": "DHSD_DROME", "mass": 19300.0, "length": 182, "protein_name": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "gene_name": "SdhD", "organism": "Fruit fly", "refseq_name": "succinate dehydrogenase, subunit D", "refseq_ac": "NP_651181", "gene_names_uniprotkb": "SdhD; CG10219", "gene_names_refseq": "BEST:GH27735; CG10219; DHSD; Dmel\\CG10219; SdhD; Sdhd", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; CybS; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone reductase membrane anchor subunit", "protein_names_refseq": "CG10219-PA; SUCCINATE DEHYDROGENASE (UBIQUINONE) CYTOCHROME B SMALL SUBUNIT; SdhD-PA; succinate dehydrogenase [ubiquinone] cytochrome B small subunit; succinate dehydrogenase cytochrome b small subunit; succinate dehydrogenase, subunit D", "tax_id": 7227, "disease": "paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 1 (Disease Ontology:DOID:0061216); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (dme:Dmel_CG10219); (R-DME-71403)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0043495 protein-membrane adaptor activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCJ8-1", "uniprot_id": "SPE_DROME", "mass": 43947.0, "length": 400, "protein_name": "Spaetzle-processing enzyme", "gene_name": "SPE", "organism": "Fruit fly", "refseq_name": "Spatzle-Processing enzyme", "refseq_ac": "NP_651168", "gene_names_uniprotkb": "SPE; CG16705; SP4; c-SP4", "gene_names_refseq": "CG16705; CT37173; Dmel\\CG16705; SP4; SPE; Sp4; c-SP4; cSP4; proPO-AE; spe", "protein_names_uniprotkb": "Spaetzle-processing enzyme; 3.4.21.-; Spatzle-processing enzyme", "protein_names_refseq": "CG16705-PA; SPE-PA; Spatzle-Processing enzyme; Spz-processing enzyme; pasteur; spz processing enzyme", "tax_id": 7227, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dme:Dmel_CG16705); (R-DME-209442)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10731132;11296245;11350927;11493599;12493753;12537569;12537572;12872120;14667416;14685264;15197269;15795223;16399077;16631589;16996061;17324925;18347020;18724373;26843333;8026333;9533958", "class_list": "", "function": "Endopeptidase which plays a key role in innate immunity by cleaving Tl ligand spz and thereby activating the Toll pathway in response to fungal and Gram-positive bacterial infections (PubMed:16399077, PubMed:16631589, PubMed:16996061, PubMed:18724373, PubMed:26843333). Acts downstream of pathogen recognition receptors PGRP-SA and GNBP1 and protease grass in response to Gram-positive bacterial infection (PubMed:16399077). Acts downstream of protease psh in response to fungal infection (PubMed:16399077)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.-", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0009620 response to fungus", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9VCJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCK0-1", "uniprot_id": "EI3D1_DROME", "mass": 63798.0, "length": 560, "protein_name": "Eukaryotic translation initiation factor 3 subunit D-1", "gene_name": "eIF3d1", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 3 subunit d1", "refseq_ac": "NP_524463", "gene_names_uniprotkb": "eIF3d1; CG10161; eIF-3p66", "gene_names_refseq": "153314_at; BEST:GM10514; CG10161; Dmel\\CG10161; GM04979; GM10514; eIF-3p66; eIF3-S7; eIF3d1; eIF3d; eIF3p66; eiF3p66", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit D-1; Eukaryotic translation initiation factor 3 subunit 7-1; Eukaryotic translation initiation factor 3 subunit p66; eIF3d-1", "protein_names_refseq": "CG10161-PB; eIF-3p66; eIF3d1-PB; eukaryotic initiation factor 3 p66 subunit; eukaryotic translation initiation factor 3 subunit d1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10161); (R-DME-156827); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10731132;12537572;18327897", "class_list": "", "function": "mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NHP3", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0098808 mRNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0002191 cap-dependent translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCK2-1", "uniprot_id": "GILT3_DROME", "mass": 24721.0, "length": 216, "protein_name": "GILT-like protein 3", "gene_name": "GILT3", "organism": "Fruit fly", "refseq_name": "Gamma-interferon-inducible lysosomal thiol reductase 3", "refseq_ac": "NP_651165", "gene_names_uniprotkb": "GILT3; CG13822", "gene_names_refseq": "CG13822; Dmel\\CG13822; GILT-3; GILT3; GILT", "protein_names_uniprotkb": "GILT-like protein 3", "protein_names_refseq": "CG13822-PA; GILT3-PA; Gamma-interferon-inducible lysosomal thiol reductase 3; Gamma-interferon-inducible lysosomal thiol reductase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13822); (R-DME-2132295)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;24491521", "class_list": "", "function": "Involved in the immune response to bacterial infection., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VCK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCN1-1", "uniprot_id": "DPOE1_DROME", "mass": 256702.0, "length": 2236, "protein_name": "DNA polymerase epsilon catalytic subunit 1", "gene_name": "PolE1", "organism": "Fruit fly", "refseq_name": "DNA polymerase epsilon subunit 1", "refseq_ac": "NP_524462", "gene_names_uniprotkb": "PolE1; CG6768; DNApol-epsilon255; DNApol-epsilon; Polepsilon; l(3)pl10R; l(3)pl10", "gene_names_refseq": "6768; BAB17608; CG6768; DNA pol epsilon; DNApol-epsilon255; DNApol-epsilon; Dmel\\CG6768; PolE1; Polepsilon255KDa; Polepsilon255; Polepsilon; dpolepsilon255; dpolepsilonp255; dpolepsilon; l(3)pl10R; l(3)pl10; pl[10]; pol-epsilon", "protein_names_uniprotkb": "DNA polymerase epsilon catalytic subunit 1; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-; DNA polymerase epsilon 255kD subunit; DNA polymerase epsilon catalytic subunit; DNA polymerase epsilon subunit 1", "protein_names_refseq": "CG6768-PA; DNA polymerase epsilon 255kD subunit; DNA polymerase epsilon subunit 1; DNA polymerase epsilon; DNApol-epsilon; DNApolymarase E; PolE1-PA; lethal (3) pl10; pol.epsilon catalytic subunit", "tax_id": 7227, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); duodenum cancer (Disease Ontology:DOID:10021); prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); cancer (Disease Ontology:DOID:162); ascending colon cancer (Disease Ontology:DOID:218); ovarian cancer (Disease Ontology:DOID:2394); kidney cancer (Disease Ontology:DOID:263); endometrial carcinoma (Disease Ontology:DOID:2871); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); anaplastic astrocytoma (Disease Ontology:DOID:3078); breast carcinoma (Disease Ontology:DOID:3459); liver cancer (Disease Ontology:DOID:3571); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pleomorphic xanthoastrocytoma (Disease Ontology:DOID:4852); endometrial serous adenocarcinoma (Disease Ontology:DOID:5750); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG6768); (R-DME-110314); (R-DME-5651801); (R-DME-5656169); (R-DME-5696400); (R-DME-6782135); (R-DME-68952); (R-DME-68962)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "10731132;11054539;12537569;12537572;15135399;21898761;22245183", "class_list": "", "function": "Catalytic component of the DNA polymerase epsilon complex (PubMed:15135399). Participates in chromosomal DNA replication (PubMed:15135399). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (PubMed:15135399). Has a role in the G1-S transition and/or S-phase progression of the mitotic cycle and endocycle progression (PubMed:11054539, PubMed:15135399, PubMed:21898761). Involved in DNA synthesis during DNA repair (By similarity). Plays roles in larval tissue development (PubMed:21898761, PubMed:22245183)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95R46", "ec_number_list": "2.7.7.7;2.7.7.6;2.7.11.22;2.7.11.23;3.1.11.-;3.1.11.2;3.1.-.-;2.4.2.-;2.4.2.30;3.6.4.12;5.6.2.4;2.7.7.-;3.6.4.13;5.6.2.3;5.2.1.8;3.4.19.12;6.5.1.1", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008296 3'-5'-DNA exonuclease activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0005634 nucleus", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading;GO:0000278 mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VCN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCP0-1", "uniprot_id": "ELOA1_DROME", "mass": 71162.0, "length": 643, "protein_name": "Transcription elongation factor B polypeptide 3", "gene_name": "EloA", "organism": "Fruit fly", "refseq_name": "elongin A, isoform B", "refseq_ac": "NP_651135", "gene_names_uniprotkb": "EloA; CG6755", "gene_names_refseq": "CG6755; Dmel\\CG6755; Elo-A; EloA; dEloA", "protein_names_uniprotkb": "Transcription elongation factor B polypeptide 3; Elongin-A; RNA polymerase II transcription factor SIII subunit A; dEloA", "protein_names_refseq": "CG6755-PB; EloA-PB; Elongin-A; ElonginA; elongin A, isoform B", "tax_id": 7227, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (dme:Dmel_CG6755); (R-DME-112382); (R-DME-674695); (R-DME-6796648); (R-DME-75955)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15509793;18327897;24204884", "class_list": "", "function": "SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). May play an important role in metamorphosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86NR0;Q95RH9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0070449 elongin complex", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II;GO:0032784 regulation of DNA-templated transcription elongation;GO:0006354 DNA-templated transcription elongation;GO:0007474 imaginal disc-derived wing vein specification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VCP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCQ3-1", "uniprot_id": "VA0D2_DROME", "mass": 40316.0, "length": 350, "protein_name": "Probable V-type proton ATPase subunit d 2", "gene_name": "VhaAC39-2", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase AC39 subunit 2", "refseq_ac": "NP_651128", "gene_names_uniprotkb": "VhaAC39-2; CG4624", "gene_names_refseq": "CG4624; Dmel\\CG4624; V0d; VhaAC39-2; anon-WO0118547.227; vhaAC39-2", "protein_names_uniprotkb": "Probable V-type proton ATPase subunit d 2; V-ATPase subunit d 2; Vacuolar H+ ATPase subunit AC39-2; Vacuolar proton pump subunit d 2", "protein_names_refseq": "CG4624-PA; VhaAC39-2-PA; vacuolar H[+] ATPase AC39 subunit 2; vacuolar H[+] ATPase subunit AC39-2", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (dme:Dmel_CG4624); (R-DME-1222556); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0PUW1;Q8MST4", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0005769 early endosome;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0033179 proton-transporting V-type ATPase, V0 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex", "go_biological_process": "GO:0007034 vacuolar transport;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0007430 terminal branching, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCQ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCR7-1", "uniprot_id": "CTNS_DROME", "mass": 44588.0, "length": 397, "protein_name": "Cystinosin", "gene_name": "Ctns", "organism": "Fruit fly", "refseq_name": "cystinosin, isoform A", "refseq_ac": "NP_651116", "gene_names_uniprotkb": "Ctns; CG17119", "gene_names_refseq": "CG17119; CTNS; Ctns; Dmel\\CG17119; dCTNS", "protein_names_uniprotkb": "Cystinosin; dCTNS", "protein_names_refseq": "CG17119-PA; Ctns-PA; cystinosin, isoform A", "tax_id": 7227, "disease": "Fanconi syndrome (Disease Ontology:DOID:1062); cystinosis (Disease Ontology:DOID:1064)", "pathway": " (dme:Dmel_CG17119); (R-DME-5223345); (R-DME-9959399)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17893096;33925313;35175796", "class_list": "", "function": "Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:35175796). Involved in cysteine homeostasis during periods of fasting, which indirectly regulates mTORC1-mediated signaling by supporting de novo CoA synthesis, the TCA cycle and amino acid metabolism during periods of food shortage (PubMed:35175796). Important for maintaining autophagy, and for development and survival during periods of fasting (PubMed:35175796)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7YZ90;Q8MS51", "ec_number_list": "", "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0015293 symporter activity;GO:0015184 L-cystine transmembrane transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:0015811 L-cystine transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VCR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCU7-1", "uniprot_id": "VRET_DROME", "mass": 78964.0, "length": 691, "protein_name": "Protein vreteno", "gene_name": "vret", "organism": "Fruit fly", "refseq_name": "vreteno", "refseq_ac": "NP_651092", "gene_names_uniprotkb": "vret; CG4771", "gene_names_refseq": "CG4771; Dmel\\CG4771; Vret; vret", "protein_names_uniprotkb": "Protein vreteno", "protein_names_refseq": "CG4771-PA; avocado; vret-PA; vretano; vreteno", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4771)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;21831924;21863019", "class_list": "", "function": "Gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Required for primary piRNA biogenesis in both germline and somatic gonadal tissues., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043186 P granule;GO:0070725 Yb body", "go_biological_process": "GO:0048477 oogenesis;GO:0051321 meiotic cell cycle;GO:0140990 primary piRNA processing;GO:0140965 secondary piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VCU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCW0-1", "uniprot_id": "CCAP_DROME", "mass": 18044.0, "length": 155, "protein_name": "Cardioactive peptide", "gene_name": "CCAP", "organism": "Fruit fly", "refseq_name": "crustacean cardioactive peptide, isoform B", "refseq_ac": "NP_001262846", "gene_names_uniprotkb": "CCAP; CG4910", "gene_names_refseq": "CCAP; CG4910; Ccap; DmCCAP; Dmel\\CG4910; ccap", "protein_names_uniprotkb": "Cardioactive peptide; CCAP; Cardioacceleratory peptide 2a; Crustacean cardioactive peptide", "protein_names_refseq": "CCAP prepropeptide; CCAP-PB; CG4910-PB; cardioacceleratory peptide; crustacean cardioactive peptide, isoform B; crustacean cardioactive peptide", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4910)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;15242619", "class_list": "", "function": "Cardioregulatory neurohormone that increases heart beat rate during adult wing inflation; has no effect on beat amplitude. The effect of CCAP is both ino- and chronotropic (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QG1", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0010460 positive regulation of heart rate", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCW0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCW1-1", "uniprot_id": "CP6D4_DROME", "mass": 59182.0, "length": 515, "protein_name": "Probable cytochrome P450 6d4", "gene_name": "Cyp6d4", "organism": "Fruit fly", "refseq_name": "cytochrome P450 6d4", "refseq_ac": "NP_651082", "gene_names_uniprotkb": "Cyp6d4; CG12800", "gene_names_refseq": "6d4; CG12800; CYP6D4; Cyp6D4; Cyp6d4; Dmel\\CG12800; Hrd", "protein_names_uniprotkb": "Probable cytochrome P450 6d4; 1.14.-.-; CYPVID4", "protein_names_refseq": "CG12800-PA; Cyp6d4-PA; cytochrome P450 6d4; cytochrome P450", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); alcohol-associated liver disease (Disease Ontology:DOID:0070658); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); essential hypertension (Disease Ontology:DOID:10825); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); familial Mediterranean fever (Disease Ontology:DOID:2987); liver cirrhosis (Disease Ontology:DOID:5082); oral submucous fibrosis (Disease Ontology:DOID:5773); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG12800)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCW1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCW3-1", "uniprot_id": "NU133_DROME", "mass": 135147.0, "length": 1200, "protein_name": "Nuclear pore complex protein Nup133", "gene_name": "Nup133", "organism": "Fruit fly", "refseq_name": "nucleoporin 133kD", "refseq_ac": "NP_651080", "gene_names_uniprotkb": "Nup133; CG6958", "gene_names_refseq": "CG6958; Dmel\\CG6958; Nup 133; Nup133; nup133", "protein_names_uniprotkb": "Nuclear pore complex protein Nup133; 133 kDa nucleoporin", "protein_names_refseq": "CG6958-PA; Nup133-PA; nucleoporin 133kD; nucleoporin 133", "tax_id": 7227, "disease": "Galloway-Mowat syndrome 1 (Disease Ontology:DOID:0060364); nephrotic syndrome type 18 (Disease Ontology:DOID:0080393); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694)", "pathway": " (dme:Dmel_CG6958); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;20547758", "class_list": "", "function": "Probable component of the nuclear pore complex (NPC) (Probable). Plays a role in NPC assembly and/or maintenance (PubMed:20547758)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86PB8;Q961A9", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VCW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VCY3-1", "uniprot_id": "CSN6_DROME", "mass": 38306.0, "length": 341, "protein_name": "COP9 signalosome complex subunit 6", "gene_name": "CSN6", "organism": "Fruit fly", "refseq_name": "COP9 signalosome subunit 6", "refseq_ac": "NP_524451", "gene_names_uniprotkb": "CSN6; CG6932", "gene_names_refseq": "CG6932; CH6; CSN6; Csn6; Dch6; Dmel\\CG6932; Q9VCY3; csn6", "protein_names_uniprotkb": "COP9 signalosome complex subunit 6; Dch6; Signalosome subunit 6", "protein_names_refseq": "CG6932-PA; COP9 complex homolog subunit 6; COP9 signalosome subunit 6; CSN6-PA; drosophila COP9 signalosome homolog 6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6932); (R-DME-5696394); (R-DME-6781823); (R-DME-8856825); (R-DME-8951664)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10531038;10731132;12537569;12537572;12737805", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0050821 protein stabilization;GO:0007281 germ cell development;GO:0048477 oogenesis;GO:0000338 protein deneddylation;GO:0048140 male germ-line cyst encapsulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VCY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VD25-1", "uniprot_id": "RPC6_DROME", "mass": 32602.0, "length": 293, "protein_name": "DNA-directed RNA polymerase III subunit RPC6", "gene_name": "Polr3F", "organism": "Fruit fly", "refseq_name": "RNA polymerase III subunit F, isoform B", "refseq_ac": "NP_001247237", "gene_names_uniprotkb": "Polr3F; CG5380", "gene_names_refseq": "CG5380; Dmel\\CG5380; Polr3F; RPC34", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC6; DNA-directed RNA polymerase III subunit F; RNA polymerase III subunit C6", "protein_names_refseq": "CG5380-PB; Polr3F-PB; RNA polymerase III subunit F, isoform B", "tax_id": 7227, "disease": "immunodeficiency 101 (Disease Ontology:DOID:0061071)", "pathway": " (dme:Dmel_CG5380); (R-DME-76061); (R-DME-76066)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540W8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VD25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VD26-1", "uniprot_id": "ZFPL1_DROME", "mass": 33503.0, "length": 299, "protein_name": "Zinc finger protein-like 1 homolog", "gene_name": "CG5382", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_732721", "gene_names_uniprotkb": "CG5382", "gene_names_refseq": "CG5382; Dmel\\CG5382; ZFPL1", "protein_names_uniprotkb": "Zinc finger protein-like 1 homolog", "protein_names_refseq": "CG5382-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5382)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VD26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VD73-1", "uniprot_id": "GLEC_DROME", "mass": 24933.0, "length": 228, "protein_name": "Gliolectin", "gene_name": "glec", "organism": "Fruit fly", "refseq_name": "gliolectin", "refseq_ac": "NP_524443", "gene_names_uniprotkb": "glec; CG6575", "gene_names_refseq": "CG6575; Dmel\\CG6575; glec", "protein_names_uniprotkb": "Gliolectin", "protein_names_refseq": "CG6575-PA; glec-PA; gliolectin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6575)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11714683;12537569;12537572;8631270", "class_list": "", "function": "Has a role in intercellular carbohydrate-mediated cell adhesion., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A9UNC5;Q24166;Q8T0Q9", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VD73-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VD83-1", "uniprot_id": "BURS_DROME", "mass": 19223.0, "length": 173, "protein_name": "Protein bursicon", "gene_name": "Burs", "organism": "Fruit fly", "refseq_name": "bursicon", "refseq_ac": "NP_650983", "gene_names_uniprotkb": "Burs; CG13419; burs-alpha", "gene_names_refseq": "BURS; Bur alpha; Burs alpha; Burs-alpha; BursA; Bursalpha; Bursicon alpha; Bursicon-alpha; Burs; CG13419; Dmel\\CG13419; burs alpha; burs-alpha; bursalpha; burs; frl; tBur", "protein_names_uniprotkb": "Protein bursicon; Bursicon subunit alpha; Cuticle-tanning hormone; burs alpha", "protein_names_refseq": "Burs-PA; CG13419-PA; bursicon alpha subunit; bursicon alpha-subunit; bursicon; furled wing", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13419)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537572;15242619;15703293;15811337;16951084;18784295;19126864", "class_list": "", "function": "Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0APJ5;C0MK54;Q573B6", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005179 hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043195 terminal bouton;GO:0031395 bursicon neuropeptide hormone complex", "go_biological_process": "GO:0036335 intestinal stem cell homeostasis;GO:0048067 cuticle pigmentation;GO:0007298 border follicle cell migration;GO:0007593 chitin-based cuticle sclerotization;GO:0030709 border follicle cell delamination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VD83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VD92-1", "uniprot_id": "ARCH_DROME", "mass": 18080.0, "length": 156, "protein_name": "Protein archease-like", "gene_name": "Archease", "organism": "Fruit fly", "refseq_name": "archease", "refseq_ac": "NP_650975", "gene_names_uniprotkb": "Archease; CG6353", "gene_names_refseq": "Archease; Arch; BcDNA:SD28072; CG6353; Disjointed; Dmel\\CG6353; disjointed; dsj", "protein_names_uniprotkb": "Protein archease-like", "protein_names_refseq": "Archease-PA; CG6353-PA; archease; disjointed", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6353)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;25961792", "class_list": "", "function": "Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (By similarity). Plays an important role in a RNA repair and splicing pathway which controls axon regeneration in response to peripheral (PNS) and central nervous system (CNS) injury, by activating splicing of Xbp1 to promote axon regeneration in response to axotomy (PubMed:25961792)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86P43", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0008033 tRNA processing;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VD92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDD1-1", "uniprot_id": "DDRGK_DROME", "mass": 34332.0, "length": 309, "protein_name": "DDRGK domain-containing protein 1", "gene_name": "Ddrgk1", "organism": "Fruit fly", "refseq_name": "DDRGK domain containing 1", "refseq_ac": "NP_650954", "gene_names_uniprotkb": "Ddrgk1; CG5862", "gene_names_refseq": "CG5862; Ddrgk1; Dmel\\CG5862", "protein_names_uniprotkb": "DDRGK domain-containing protein 1", "protein_names_refseq": "CG5862-PA; DDRGK domain containing 1; Ddrgk1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5862)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;37086384", "class_list": "", "function": "Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins (By similarity). Required for ufmylation of Atg9; protects the nervous system during aging, possibly by stabilizing Atg9 and supporting its function (PubMed:37086384)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0044389 ubiquitin-like protein ligase binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0071569 protein ufmylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VDD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDD7-1", "uniprot_id": "S35B1_DROME", "mass": 37438.0, "length": 338, "protein_name": "Solute carrier family 35 member B1 homolog", "gene_name": "meigo", "organism": "Fruit fly", "refseq_name": "medial glomeruli, isoform B", "refseq_ac": "NP_001097853", "gene_names_uniprotkb": "meigo; CG5802", "gene_names_refseq": "CG5802; Dmel\\CG5802; Meigo; NEST:bs03h03; anon-EST:fe1H6; meigo", "protein_names_uniprotkb": "Solute carrier family 35 member B1 homolog; Protein medial glomeruli", "protein_names_refseq": "CG5802-PB; NEST:bs03h03; anon-fast-evolving-1H6; medial glomeruli, isoform B; meigo-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5802)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JR61", "ec_number_list": "", "go_molecular_function": "GO:0005459 UDP-galactose transmembrane transporter activity;GO:0005460 UDP-glucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0007411 axon guidance;GO:0034976 response to endoplasmic reticulum stress;GO:0072334 UDP-galactose transmembrane transport;GO:0070983 dendrite guidance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VDD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDH4-1", "uniprot_id": "TOTB_DROME", "mass": 15594.0, "length": 138, "protein_name": "Protein Turandot B", "gene_name": "TotB", "organism": "Fruit fly", "refseq_name": "turandot B", "refseq_ac": "NP_524422", "gene_names_uniprotkb": "TotB; CG5609", "gene_names_refseq": "BcDNA:LP06769; CG5609; Dmel\\CG5609; TOTB; Tot B; TotB; tot", "protein_names_uniprotkb": "Protein Turandot B", "protein_names_refseq": "CG5609-PA; TotB-PA; turandot B; turandot", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5609)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11409894;12537569;12537572", "class_list": "", "function": "A humoral factor that may play a role in stress tolerance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q962E0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0034605 cellular response to heat;GO:0009617 response to bacterium;GO:0009411 response to UV;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VDH4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDQ0-1", "uniprot_id": "INDY2_DROME", "mass": 61935.0, "length": 562, "protein_name": "Protein I'm not dead yet 2", "gene_name": "Indy2", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Indy2; CG33933", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein I'm not dead yet 2", "protein_names_refseq": "", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 25 (Disease Ontology:DOID:0080453)", "pathway": " (dme:Dmel_CG33933); (R-DME-433137); (R-DME-9955298)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;11118146;12537569;12537572", "class_list": "", "function": "Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V353;Q95T83", "ec_number_list": "", "go_molecular_function": "GO:0015137 citrate transmembrane transporter activity;GO:0050833 pyruvate transmembrane transporter activity;GO:0015141 succinate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015746 citrate transport;GO:0008340 determination of adult lifespan;GO:0015744 succinate transport;GO:0006848 pyruvate transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VDQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDR1-1", "uniprot_id": "MED25_DROME", "mass": 96642.0, "length": 863, "protein_name": "Mediator of RNA polymerase II transcription subunit 25", "gene_name": "MED25", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 25", "refseq_ac": "NP_650854", "gene_names_uniprotkb": "MED25; Arc92; CG12254", "gene_names_refseq": "Arc92; CG12254; Dmel\\CG12254; LD07688; MED25; Med25; dARC92; dDrip97; med25", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 25; Mediator complex subunit 25; dmPTOV2", "protein_names_refseq": "CG12254-PA; MED25-PA; mediator complex subunit 25", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12254)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;16751183", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006963 positive regulation of antibacterial peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VDR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDS6-1", "uniprot_id": "SURF6_DROME", "mass": 38135.0, "length": 324, "protein_name": "Surfeit locus protein 6 homolog", "gene_name": "Surf6", "organism": "Fruit fly", "refseq_name": "surfeit 6", "refseq_ac": "NP_524408", "gene_names_uniprotkb": "Surf6; CG4510", "gene_names_refseq": "CG4510; Dmel\\CG4510; Surf6", "protein_names_uniprotkb": "Surfeit locus protein 6 homolog", "protein_names_refseq": "CG4510-PA; Surf6-PA; surfeit 6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4510)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;17372656", "class_list": "", "function": "Involved in a nucleolar function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQW1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0042254 ribosome biogenesis;GO:0042274 ribosomal small subunit biogenesis;GO:0007419 ventral cord development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VDS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDV3-1", "uniprot_id": "NUP58_DROME", "mass": 55528.0, "length": 546, "protein_name": "Nuclear pore complex protein Nup58", "gene_name": "Nup58", "organism": "Fruit fly", "refseq_name": "nucleoporin 58kD", "refseq_ac": "NP_650821", "gene_names_uniprotkb": "Nup58; CG7360", "gene_names_refseq": "CG7360; Dm NUP58; Dmel\\CG7360; Nup58; RE52572p; nup58", "protein_names_uniprotkb": "Nuclear pore complex protein Nup58; Nucleoporin Nup58", "protein_names_refseq": "CG7360-PA; Nup58-PA; nucleoporin 58kD; nucleoporin 58", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7360); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;15086791;24706800;28604694;33856346;40245499", "class_list": "", "function": "Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (PubMed:15086791). Together with Nup54, required for transposable element silencing regulation in ovarian follicle cells (PubMed:33856346). By interacting with the nuclear (Nxf1/Nxt1) and cytosolic (fs(1)Yb) components of the flamenco (flam) transcripts processing pathway, enables export and subsequent piRNA production (PubMed:33856346)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYM7", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9VDV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VDY1-1", "uniprot_id": "INO80_DROME", "mass": 187086.0, "length": 1638, "protein_name": "Chromatin-remodeling ATPase INO80", "gene_name": "Ino80", "organism": "Fruit fly", "refseq_name": "INO80 complex subunit", "refseq_ac": "NP_732413", "gene_names_uniprotkb": "Ino80; CG31212", "gene_names_refseq": "CG14279; CG18491; CG31212; CG3602; Dmel\\CG31212; Gaiano strain; INO80; Ino80; Tel; dINO80; dIno80; psg25", "protein_names_uniprotkb": "Chromatin-remodeling ATPase INO80; 3.6.4.-; dINO80", "protein_names_refseq": "CG31212-PA; INO80 complex subunit; Ino80-PA; telomere elongation", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31212); (R-DME-5689603); (R-DME-5696394)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16618800;18327897", "class_list": "", "function": "ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T9F9", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-;3.4.-.-;3.4.19.12", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000976 transcription cis-regulatory region binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031011 Ino80 complex;GO:0000785 chromatin;GO:0005700 polytene chromosome", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VDY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VE09-1", "uniprot_id": "GATA_DROME", "mass": 55819.0, "length": 508, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "gene_name": "GatA", "organism": "Fruit fly", "refseq_name": "Glutamyl-tRNA amidotransferase, subunit A", "refseq_ac": "NP_650775", "gene_names_uniprotkb": "GatA; CG6007", "gene_names_refseq": "0929/02; CG6007; Dmel\\CG6007; GATA; GatA; benedict; bene; gatA; l(3)S092902", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; 6.3.5.7; Glu-AdT subunit A", "protein_names_refseq": "CG6007-PA; GatA-PA; Glutamyl-tRNA amidotransferase, subunit A; Glutamyl-tRNA(Gln) amidotransferase, subunit A; benedict; gatA; glutamyl-tRNA amidotransferase A; glutamyl-tRNA amidotransferase subunit A; lethal (3) S092902", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); combined oxidative phosphorylation deficiency 40 (Disease Ontology:DOID:0112117)", "pathway": " (dme:Dmel_CG6007)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95R50;Q9U9C8", "ec_number_list": "6.3.5.-;6.3.5.7", "go_molecular_function": "GO:0005524 ATP binding;GO:0017171 serine hydrolase activity;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VE09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VE11-1", "uniprot_id": "U488_DROME", "mass": 22024.0, "length": 200, "protein_name": "UPF0488 protein CG14286", "gene_name": "CG14286", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_650772", "gene_names_uniprotkb": "CG14286", "gene_names_refseq": "14286; CG14286; Dmel\\CG14286", "protein_names_uniprotkb": "UPF0488 protein CG14286", "protein_names_refseq": "CG14286-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14286)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQ13", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VE11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VE87-1", "uniprot_id": "HMW_DROME", "mass": 67635.0, "length": 604, "protein_name": "Protein hemingway", "gene_name": "hmw", "organism": "Fruit fly", "refseq_name": "hemingway", "refseq_ac": "NP_650714", "gene_names_uniprotkb": "hmw; CG7669", "gene_names_refseq": "CG7669; Dmel\\CG7669; anon-WO0140519.198; hmw", "protein_names_uniprotkb": "Protein hemingway", "protein_names_refseq": "CG7669-PA; Hmw; hemingway; hmw-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7669)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;24554765", "class_list": "", "function": "Involved in assembly and/or maintenance of motile cilia. Required during spermatogenesis for axoneme elongation. Necessary for optimal function of the chordotonal (hearing) organs., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0T7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0043204 perikaryon", "go_biological_process": "GO:0007283 spermatogenesis;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0044458 motile cilium assembly;GO:0007291 sperm individualization;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VE87-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VEB3-1", "uniprot_id": "RPF2_DROME", "mass": 36498.0, "length": 320, "protein_name": "Ribosome production factor 2 homolog", "gene_name": "Non3", "organism": "Fruit fly", "refseq_name": "putative nucleolar protein 3", "refseq_ac": "NP_650694", "gene_names_uniprotkb": "Non3; CG7993", "gene_names_refseq": "CG7993; Dmel\\CG7993; Non3", "protein_names_uniprotkb": "Ribosome production factor 2 homolog; Brix domain-containing protein 1 homolog; Novel nucleolar protein 3; Ribosome biogenesis protein RPF2 homolog", "protein_names_refseq": "CG7993-PA; Non3-PA; putative nucleolar protein 3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7993)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;24255106", "class_list": "", "function": "Required for normal assembly of the mitotic spindle. May be involved in both centrosome-dependent and centrosome-independent spindle assembly programs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95U84", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0051301 cell division;GO:0000027 ribosomal large subunit assembly;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VEB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VEI3-1", "uniprot_id": "S35B2_DROME", "mass": 52282.0, "length": 465, "protein_name": "Adenosine 3'-phospho 5'-phosphosulfate transporter 1", "gene_name": "sll", "organism": "Fruit fly", "refseq_name": "slalom, isoform B", "refseq_ac": "NP_001247153", "gene_names_uniprotkb": "sll; CG7623; PAPST1", "gene_names_refseq": "1422/14; CG7623; Dmel\\CG7623; Sll; anon-WO0118547.555; anon-WO0172774.85; l(3)S142214; sll", "protein_names_uniprotkb": "Adenosine 3'-phospho 5'-phosphosulfate transporter 1; PAPS transporter 1; Protein slalom", "protein_names_refseq": "CG7623-PB; slalom, isoform B; slalom; sll-PB", "tax_id": 7227, "disease": "hypomyelinating leukodystrophy 26 (Disease Ontology:DOID:0070403)", "pathway": " (dme:Dmel_CG7623); (R-DME-174362); (R-DME-727802)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;12716889;12853478", "class_list": "", "function": "Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Required for the dorsoventral patterning, suggesting that it mediates the transport of the sulfate donor required for the sulfotransferase activity of pip (pipe)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q960E7", "ec_number_list": "", "go_molecular_function": "GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport;GO:0007310 oocyte dorsal/ventral axis specification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VEI3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VEU1-1", "uniprot_id": "CAD89_DROME", "mass": 250636.0, "length": 2240, "protein_name": "Cadherin-89D", "gene_name": "Cad89D", "organism": "Fruit fly", "refseq_name": "cadherin 89D", "refseq_ac": "NP_650554", "gene_names_uniprotkb": "Cad89D; CG14900", "gene_names_refseq": "CG14900; CT34724; Cad89D; DCad89D; Dmel\\CG14900", "protein_names_uniprotkb": "Cadherin-89D", "protein_names_refseq": "CG14900-PB; Cad89D-PB; cadherin 89D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14900)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity)., [UniProtKB]", "predicted_glycosites": 19, "predicted_n_glycosites": 19, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q6NR53;Q9GR86", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0007409 axonogenesis;GO:0030855 epithelial cell differentiation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0044331 cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VEU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VEX0-1", "uniprot_id": "SULF1_DROME", "mass": 127303.0, "length": 1114, "protein_name": "Extracellular sulfatase SULF-1 homolog", "gene_name": "Sulf1", "organism": "Fruit fly", "refseq_name": "sulfated, isoform B", "refseq_ac": "NP_001262626", "gene_names_uniprotkb": "Sulf1; CG6725", "gene_names_refseq": "CG6725; DSulf1; DSulf; Dmel\\CG6725; Dsulf1; Neu5; Sulf-1; Sulf1; sulf1; sulf", "protein_names_uniprotkb": "Extracellular sulfatase SULF-1 homolog; 3.1.6.-; DmSulf-1", "protein_names_refseq": "CG6725-PB; HS 6-O-sulfatase 1; Sulf1-PB; sulfated, isoform B; sulfated", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6725)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;17893096", "class_list": "", "function": "", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRG1;Q9NIH6", "ec_number_list": "", "go_molecular_function": "GO:0008449 N-acetylglucosamine-6-sulfatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0005795 Golgi stack", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0010575 positive regulation of vascular endothelial growth factor production;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VEX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VEX6-1", "uniprot_id": "ATD3A_DROME", "mass": 68361.0, "length": 604, "protein_name": "ATPase family AAA domain-containing protein 3A homolog", "gene_name": "bor", "organism": "Fruit fly", "refseq_name": "belphegor, isoform B", "refseq_ac": "NP_001247135", "gene_names_uniprotkb": "bor; CG6815; Dmel_CG6815", "gene_names_refseq": "ATAD3A; Bor; CG6815; CP89BC; Dmel\\CG6815; bor; dATAD3A; dAtad3a; denuded", "protein_names_uniprotkb": "ATPase family AAA domain-containing protein 3A homolog; Belphegor protein", "protein_names_refseq": "CG6815-PB; belphegor, isoform B; belphegor; bor-PB; cytoplasmic protein 89BC; denuded", "tax_id": 7227, "disease": "Harel-Yoon syndrome (Disease Ontology:DOID:0081395); neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome (Disease Ontology:DOID:0081396)", "pathway": " (dme:Dmel_CG6815); (R-DME-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;27640307", "class_list": "", "function": "Required to maintain the proper number of mitochondria in neurons and muscles., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VEX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VF27-1", "uniprot_id": "NDUS8_DROME", "mass": 24578.0, "length": 217, "protein_name": "NADH dehydrogenase (ubiquinone) 23 kDa subunit", "gene_name": "ND-23", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase (ubiquinone) 23 kDa subunit", "refseq_ac": "NP_524719", "gene_names_uniprotkb": "ND-23; CG3944; NUIM; dNDUFS8", "gene_names_refseq": "CG3944; Dmel\\CG3944; ND 23; ND-23; ND23; NDUFS8; NUIM; dNDUFS8", "protein_names_uniprotkb": "NADH dehydrogenase (ubiquinone) 23 kDa subunit; 7.1.1.2", "protein_names_refseq": "CG3944-PA; COMPLEX I: 23 kDa subunit; NADH dehydrogenase (ubiquinone) 23 kDa subunit; NADH ubiquinone oxidoreductase 23 kDa; NADH-UBIQUINONE OXIDOREDUCTASE 23 KDA SUBUNIT; NADH: UBIQUINONE REDUCTASE 23 KD SUBUNIT PRECURSOR; NADH:ubiquinone oxidoreductase 23 kDa subunit; NADH:ubiquinone reductase 23kD subunit precursor; ND-23-PA", "tax_id": 7227, "disease": "nuclear type mitochondrial complex I deficiency 2 (Disease Ontology:DOID:0112083); Leigh disease (Disease Ontology:DOID:3652); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG3944); (R-DME-611105); (R-DME-6799198)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;28683319;29285794;29496745", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZF2", "ec_number_list": "7.1.1.2;2.1.1.320;1.-.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042775 mitochondrial ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VF27-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VF81-1", "uniprot_id": "TMTC4_DROME", "mass": 80451.0, "length": 705, "protein_name": "Protein O-mannosyl-transferase Tmtc4", "gene_name": "Tmtc4", "organism": "Fruit fly", "refseq_name": "transmembrane O-mannosyltransferase targeting cadherins 4", "refseq_ac": "NP_650451", "gene_names_uniprotkb": "Tmtc4; CG5038", "gene_names_refseq": "CG5038; Dmel\\CG5038; TMTC4; Tmtc4", "protein_names_uniprotkb": "Protein O-mannosyl-transferase Tmtc4; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 4; Transmembrane and tetratricopeptide repeat-containing protein 4", "protein_names_refseq": "CG5038-PA; Tmtc4-PA; transmembrane O-mannosyltransferase targeting cadherins 4", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565)", "pathway": " (dme:Dmel_CG5038)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.109", "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VF81-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VFC0-1", "uniprot_id": "SCC4_DROME", "mass": 71217.0, "length": 632, "protein_name": "MAU2 chromatid cohesion factor homolog", "gene_name": "Mau2", "organism": "Fruit fly", "refseq_name": "Mau2 sister chromatid cohesion factor", "refseq_ac": "NP_650428", "gene_names_uniprotkb": "Mau2; CG4203", "gene_names_refseq": "CG4203; Dmel\\CG4203; FBgn0038300; MAU-2; MAU2; Mau-2; Mau2; mau-2", "protein_names_uniprotkb": "MAU2 chromatid cohesion factor homolog; Cohesin loading complex subunit SCC4 homolog; Mau2 sister chromatid cohesion factor", "protein_names_refseq": "CG4203-PA; Mau2 sister chromatid cohesion factor; Mau2-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4203); (R-DME-2470946)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032116 SMC loading complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007411 axon guidance;GO:0034088 maintenance of mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VFC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VFJ2-1", "uniprot_id": "RM11_DROME", "mass": 21612.0, "length": 196, "protein_name": "Large ribosomal subunit protein uL11m", "gene_name": "mRpL11", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L11", "refseq_ac": "NP_524351", "gene_names_uniprotkb": "mRpL11; CG3351", "gene_names_refseq": "BcDNA:RE67638; CG3351; Dmel\\CG3351; L11; mRpL11; rpl-11", "protein_names_uniprotkb": "Large ribosomal subunit protein uL11m; 39S ribosomal protein L11, mitochondrial; L11mt; MRP-L11", "protein_names_refseq": "CG3351-PA; mRpL11-PA; mitochondrial ribosomal protein L11", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3351); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit", "go_biological_process": "GO:0006417 regulation of translation;GO:0006412 translation;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VFJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VFM9-1", "uniprot_id": "TWF_DROME", "mass": 39070.0, "length": 343, "protein_name": "Twinfilin", "gene_name": "twf", "organism": "Fruit fly", "refseq_name": "twinfilin", "refseq_ac": "NP_650338", "gene_names_uniprotkb": "twf; CG3172", "gene_names_refseq": "A6; CG3172; Dmel\\CG3172; Twf; twf", "protein_names_uniprotkb": "Twinfilin", "protein_names_refseq": "CG3172-PA; twf-PA; twinfilin; twinfillin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3172); (R-DME-9013418)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;11724820;12537569;12537572", "class_list": "", "function": "Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030016 myofibril", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0010976 positive regulation of neuron projection development;GO:0051016 barbed-end actin filament capping;GO:0030833 regulation of actin filament polymerization;GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VFM9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VFS6-1", "uniprot_id": "INT5_DROME", "mass": 112972.0, "length": 994, "protein_name": "Integrator complex subunit 5", "gene_name": "omd", "organism": "Fruit fly", "refseq_name": "oocyte maintenance defects, isoform B", "refseq_ac": "NP_001262542", "gene_names_uniprotkb": "omd; CG9591; IntS5", "gene_names_refseq": "CG9591; Dmel\\CG9591; IntS5; Omd; intS5; omd", "protein_names_uniprotkb": "Integrator complex subunit 5; Protein oocyte maintenance defects", "protein_names_refseq": "CG9591-PB; integrator 5; omd-PB; oocyte maintenance defects, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9591); (R-DME-6807505)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;21078872;23097424;31530651;32966759;37995689;39032490", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:21078872, PubMed:23097424, PubMed:32966759). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity (PubMed:32966759). The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95R54", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0032039 integrator complex", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0045666 positive regulation of neuron differentiation;GO:0030514 negative regulation of BMP signaling pathway;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VFS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VFS8-1", "uniprot_id": "PSMD9_DROME", "mass": 23898.0, "length": 220, "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "CG9588", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_650301", "gene_names_uniprotkb": "CG9588", "gene_names_refseq": "9588; CG9588; Dmel\\CG9588; dp27; p27", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 9; 26S proteasome regulatory subunit p27; dp27", "protein_names_refseq": "CG9588-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9588); (R-DME-9907900)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;23622245", "class_list": "", "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070682 proteasome regulatory particle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VFS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VFX3-1", "uniprot_id": "APN_DROME", "mass": 14446.0, "length": 137, "protein_name": "Protein apnoia", "gene_name": "apn", "organism": "Fruit fly", "refseq_name": "apnoia", "refseq_ac": "NP_650270", "gene_names_uniprotkb": "apn; CG15887", "gene_names_refseq": "Apn; BcDNA:RE53127; CG15887; Dmel\\CG15887; apn", "protein_names_uniprotkb": "Protein apnoia", "protein_names_refseq": "CG15887-PA; apn-PA; apnoia", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15887)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;30645584", "class_list": "", "function": "Transmembrane protein that plays a key role in trachea development by regulating crb localization and maintenance at the apical cell membrane (PubMed:30645584). Required for anisotropic apical surface expansion important for tracheal tube elongation and lumen stability at larval stages (PubMed:30645584)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0060438 trachea development;GO:1905477 positive regulation of protein localization to membrane;GO:0007424 open tracheal system development;GO:0035001 dorsal trunk growth, open tracheal system;GO:0035002 liquid clearance, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VFX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VG40-1", "uniprot_id": "CP134_DROME", "mass": 57114.0, "length": 494, "protein_name": "Probable cytochrome P450 313a4", "gene_name": "Cyp313a4", "organism": "Fruit fly", "refseq_name": "cytochrome P450 313a4", "refseq_ac": "NP_650224", "gene_names_uniprotkb": "Cyp313a4; CG6802", "gene_names_refseq": "313a4; CG6802; Cyp313A4; Cyp313a4; Dmel\\CG6802", "protein_names_uniprotkb": "Probable cytochrome P450 313a4; 1.14.-.-; CYPCCCXIIIA4", "protein_names_refseq": "CG6802-PA; Cyp313a4-PA; cytochrome P450 313a4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6802)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QH3", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VG40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VG74-1", "uniprot_id": "SIAS_DROME", "mass": 41218.0, "length": 372, "protein_name": "N-acetylneuraminate-9-phosphate synthase", "gene_name": "Nans", "organism": "Fruit fly", "refseq_name": "N-acetylneuraminic acid synthase", "refseq_ac": "NP_650195", "gene_names_uniprotkb": "Nans; CG5232; Sas", "gene_names_refseq": "CG5232; DmSAS; Dmel\\CG5232; NANS; Nans; Neu5Ac; SAS; Sas; sas", "protein_names_uniprotkb": "N-acetylneuraminate-9-phosphate synthase; 2.5.1.132; 2.5.1.57; 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase; Sialic acid synthase", "protein_names_refseq": "CG5232-PA; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase; NANS-PA; Neu5Ac synthase; sialic acid phosphate synthase; sialic acid synthase", "tax_id": 7227, "disease": "spondyloepimetaphyseal dysplasia, Genevieve-type (Disease Ontology:DOID:0080576)", "pathway": " (dme:Dmel_CG5232); (R-DME-4085001)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;11886840;12537572;21919466", "class_list": "", "function": "Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) or D-mannose 6-phosphate (Man-6-P) to generate the phosphorylated forms of both the sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:11886840). Essential for biosynthesis of sialic acids in neurons of the central nervous system (PubMed:21919466)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DMY1;Q95VY1", "ec_number_list": "2.5.1.57;2.5.1.132", "go_molecular_function": "GO:0047444 N-acylneuraminate-9-phosphate synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process;GO:0046380 N-acetylneuraminate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VG74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VG76-1", "uniprot_id": "MYCBP_DROME", "mass": 20153.0, "length": 181, "protein_name": "Myc-binding protein", "gene_name": "Mycbp", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_650194", "gene_names_uniprotkb": "Mycbp; CG17202", "gene_names_refseq": "BcDNA:RH21090; CG17202; Dmel\\CG17202", "protein_names_uniprotkb": "Myc-binding protein", "protein_names_refseq": "CG17202-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17202)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;40215271", "class_list": "", "function": "Part of a complex with bbn and otu (PubMed:40215271). Essential for female fertility; involved in germ cell proliferation and germ cell differentiation (PubMed:40215271)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8SX10", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0019099 female germ-line sex determination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VG76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VG94-1", "uniprot_id": "GSTD6_DROME", "mass": 24485.0, "length": 215, "protein_name": "Glutathione S-transferase D6", "gene_name": "GstD6", "organism": "Fruit fly", "refseq_name": "glutathione S transferase D6", "refseq_ac": "NP_524915", "gene_names_uniprotkb": "GstD6; CG4423; GSTD6-6; gstD25", "gene_names_refseq": "CG4423; DmGST25; DmGSTD6; DmGstd6; Dmel\\CG4423; GSTD6; GST; Gst D6; Gst-D6; GstD25; GstD6; Gst; gstD25; gstd6; gst", "protein_names_uniprotkb": "Glutathione S-transferase D6; 2.5.1.18", "protein_names_refseq": "CG4423-PA; GstD6-PA; glutathione S transferase D25; glutathione S transferase D6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4423)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;22082028;7683659", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9TX93", "ec_number_list": "2.5.1.18;4.5.1.1;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009636 response to toxic substance;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VG94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VG96-1", "uniprot_id": "GSTD4_DROME", "mass": 24736.0, "length": 215, "protein_name": "Glutathione S-transferase D4", "gene_name": "GstD4", "organism": "Fruit fly", "refseq_name": "glutathione S transferase D4", "refseq_ac": "NP_524913", "gene_names_uniprotkb": "GstD4; CG11512; GSTD4-4; gstD23", "gene_names_refseq": "CG11512; DmGST23; DmGSTD4; DmGstd4; Dmel\\CG11512; GSTD4; GST; GstD23; GstD4; Gst; gstD23; gstD4; gstd4; gst", "protein_names_uniprotkb": "Glutathione S-transferase D4; 2.5.1.18", "protein_names_refseq": "CG11512-PA; Glutathione-S-transferase; GstD4-PA; glutathione S transferase D23; glutathione S transferase D4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11512)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;22082028;7683659", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q541F8;Q9TX90", "ec_number_list": "2.5.1.18;4.5.1.1;5.2.1.2", "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009636 response to toxic substance;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VG96-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGB3-1", "uniprot_id": "CP133_DROME", "mass": 56195.0, "length": 492, "protein_name": "Probable cytochrome P450 313a3", "gene_name": "Cyp313a3", "organism": "Fruit fly", "refseq_name": "cytochrome P450 313a3", "refseq_ac": "NP_650170", "gene_names_uniprotkb": "Cyp313a3; CG10093", "gene_names_refseq": "313a3; CG10093; CYP313a3; Cyp313a3; Dmel\\CG10093", "protein_names_uniprotkb": "Probable cytochrome P450 313a3; 1.14.-.-; CYPCCCXIIIA3", "protein_names_refseq": "CG10093-PA; Cyp313a3-PA; cytochrome P450 313a3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10093)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VGB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGH1-1", "uniprot_id": "CP315_DROME", "mass": 59631.0, "length": 520, "protein_name": "Cytochrome P450 315a1, mitochondrial", "gene_name": "sad", "organism": "Fruit fly", "refseq_name": "shadow", "refseq_ac": "NP_650123", "gene_names_uniprotkb": "sad; CG14728; Cyp315a1", "gene_names_refseq": "315a1; CG14728; CYP315A1; Cyp315a1; Dmel\\CG14728; Sad; sad", "protein_names_uniprotkb": "Cytochrome P450 315a1, mitochondrial; 1.14.15.-; CYPCCCXVA1; Protein shadow", "protein_names_refseq": "CG14728-PA; cytochrome P450; ecdysteroid hydroxylase; karmoisin ghost; sad-PA; shadow", "tax_id": 7227, "disease": "vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); rickets (Disease Ontology:DOID:10609); extrahepatic cholestasis (Disease Ontology:DOID:13619); nephrosis (Disease Ontology:DOID:2527); acute kidney failure (Disease Ontology:DOID:3021); Wilson disease (Disease Ontology:DOID:893)", "pathway": " (dme:Dmel_CG14728); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;12177427;12537572;14610274", "class_list": "", "function": "Required for CNS development: midline glial cells. Involved in the metabolism of insect hormones: responsible for ecdysteroid C2-hydroxylase activity. May be involved in the breakdown of synthetic insecticides., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U131;Q8MTR7", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0042768 ecdysteroid 2-hydroxylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0007417 central nervous system development;GO:0007494 midgut development;GO:0008045 motor neuron axon guidance;GO:0006697 ecdysone biosynthetic process;GO:0007391 dorsal closure", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VGH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGI8-1", "uniprot_id": "BLM_DROME", "mass": 166079.0, "length": 1487, "protein_name": "RecQ-like DNA helicase Blm", "gene_name": "Blm", "organism": "Fruit fly", "refseq_name": "bloom syndrome helicase", "refseq_ac": "NP_524319", "gene_names_uniprotkb": "Blm; CG6920; mus309", "gene_names_refseq": "BLM; Blm; Bloom; CG6920; DmBLM; DmBlm; DmKu70; Dmblm; Dmel\\CG6920; Ku70; MUS309; Mus309; RecQ; blm; dBLM; dBlm; dmblm; ku70; mus 309; mus309", "protein_names_uniprotkb": "RecQ-like DNA helicase Blm; 5.6.2.4; Bloom syndrome helicase ortholog; Bloom syndrome protein homolog; DNA 3'-5' helicase BLM; Dmblm; Mutagen-sensitive protein 309; RecQ helicase homolog", "protein_names_refseq": "Blm-PA; Bloom's helicase; CG6920-PA; RecQ-like; bloom helicase; bloom syndrome helicase ortholog; bloom syndrome helicase; drosophila Blm; genome stabilizer 1; gesta1; mutagen-sensitive 309", "tax_id": 7227, "disease": "Bloom syndrome (Disease Ontology:DOID:2717); Werner syndrome (Disease Ontology:DOID:5688)", "pathway": " (dme:Dmel_CG6920); (R-DME-3108214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10049920;10731132;12537572;18327897;25205745;37268618", "class_list": "", "function": "Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Involved in DNA double strand break repair, including the synthesis-dependent strand annealing (SDSA) pathway (PubMed:25205745). Involved in DNA interstrand cross-link repair (PubMed:25205745)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Y062", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0000403 Y-form DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0031422 RecQ family helicase-topoisomerase III complex", "go_biological_process": "GO:1901291 negative regulation of double-strand break repair via single-strand annealing;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VGI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGN9-1", "uniprot_id": "RLP24_DROME", "mass": 22436.0, "length": 191, "protein_name": "Probable ribosome biogenesis protein RLP24", "gene_name": "RpL24-like", "organism": "Fruit fly", "refseq_name": "ribosomal protein L24-like", "refseq_ac": "NP_650073", "gene_names_uniprotkb": "RpL24-like; CG6764", "gene_names_refseq": "CG6764; Dmel\\CG6764; RpL24-like; Rpl24-like", "protein_names_uniprotkb": "Probable ribosome biogenesis protein RLP24", "protein_names_refseq": "CG6764-PA; RpL24-like-PA; ribosomal protein L24-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6764)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VGN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGP1-1", "uniprot_id": "ZFY26_DROME", "mass": 253674.0, "length": 2243, "protein_name": "Zinc finger FYVE domain-containing protein 26 homolog", "gene_name": "Sptz", "organism": "Fruit fly", "refseq_name": "spastizin", "refseq_ac": "NP_731570", "gene_names_uniprotkb": "Sptz; CG5270", "gene_names_refseq": "CG5270; D-Sptz; Dmel\\CG5270; Sptz; sptz", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 26 homolog; Protein Spastizin; ZFYVE26", "protein_names_refseq": "CG5270-PB; D-Spastizin; Sptz-PB; spastizin", "tax_id": 7227, "disease": "hereditary spastic paraplegia 15 (Disease Ontology:DOID:0110768)", "pathway": " (dme:Dmel_CG5270)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;36029068", "class_list": "", "function": "Phosphatidylinositol 3-phosphate (PtdIns[3]P)-binding protein (By similarity). Involved in autophagy (PubMed:36029068)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q86NZ0;Q961I5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody", "go_biological_process": "GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0000281 mitotic cytokinesis;GO:0000724 double-strand break repair via homologous recombination;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VGP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGW6-1", "uniprot_id": "MCM5_DROME", "mass": 82258.0, "length": 733, "protein_name": "DNA replication licensing factor Mcm5", "gene_name": "Mcm5", "organism": "Fruit fly", "refseq_name": "minichromosome maintenance 5", "refseq_ac": "NP_524308", "gene_names_uniprotkb": "Mcm5; CG4082", "gene_names_refseq": "CG4082; DmCDC465; DmCDC46; DmMCM5; DmMcm5; DmeMCM5; Dmel\\CG4082; MCM5; McM5; Mcm5; PCR4; mcm5", "protein_names_uniprotkb": "DNA replication licensing factor Mcm5; 3.6.4.12; DmMCM5; Minichromosome maintenance 5 protein", "protein_names_refseq": "CG4082-PA; Mcm5-PA; mini-chromosome maintenance 5; minichromosome maintenance 5", "tax_id": 7227, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 8 (Disease Ontology:DOID:0080255); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG4082); (R-DME-176187); (R-DME-68867); (R-DME-68949); (R-DME-68962); (R-DME-69052)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10731132;12537572;16798881;20122406;9224901", "class_list": "", "function": "Acts as a component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P91676", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;2.7.11.22;2.7.11.23;2.7.7.7;3.1.11.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;2.7.7.-;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006260 DNA replication;GO:0030261 chromosome condensation;GO:0006270 DNA replication initiation;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VGW6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VGZ0-1", "uniprot_id": "C12E1_DROME", "mass": 59684.0, "length": 522, "protein_name": "Probable cytochrome P450 12e1, mitochondrial", "gene_name": "Cyp12e1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 12e1", "refseq_ac": "NP_650003", "gene_names_uniprotkb": "Cyp12e1; CG14680", "gene_names_refseq": "12e1; CG14680; Cyp12E1; Cyp12e1; Cyp12e; Dmel\\CG14680", "protein_names_uniprotkb": "Probable cytochrome P450 12e1, mitochondrial; 1.14.-.-; CYPXIIE1", "protein_names_refseq": "CG14680-PC; Cyp12e1-PC; cytochrome P450 12e1", "tax_id": 7227, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); infantile hypercalcemia 1 (Disease Ontology:DOID:0061136); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); gestational diabetes (Disease Ontology:DOID:11714); lung cancer (Disease Ontology:DOID:1324); extrahepatic cholestasis (Disease Ontology:DOID:13619); alcohol use disorder (Disease Ontology:DOID:1574); rectum cancer (Disease Ontology:DOID:1993); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); ovary adenocarcinoma (Disease Ontology:DOID:3713); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cerebrotendinous xanthomatosis (Disease Ontology:DOID:4810); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); lung small cell carcinoma (Disease Ontology:DOID:5409); ulcerative colitis (Disease Ontology:DOID:8577); Wilson disease (Disease Ontology:DOID:893); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG14680)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V453;Q4V470;Q8INL9", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0031966 mitochondrial membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VGZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VH08-1", "uniprot_id": "SIR6_DROME", "mass": 35204.0, "length": 317, "protein_name": "NAD-dependent protein deacetylase Sirt6", "gene_name": "Sirt6", "organism": "Fruit fly", "refseq_name": "sirtuin 6", "refseq_ac": "NP_649990", "gene_names_uniprotkb": "Sirt6; CG6284", "gene_names_refseq": "CG6284; D.mel4; Dmel\\CG6284; Sirt6; dSIRT6; dmSRT408; sirt6", "protein_names_uniprotkb": "NAD-dependent protein deacetylase Sirt6; 2.3.1.286; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; dSirt6", "protein_names_refseq": "CG6284-PB; Sirt6-PB; sirtuin 6", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); transient cerebral ischemia (Disease Ontology:DOID:224); progeria (Disease Ontology:DOID:3911); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG6284)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;17159295;35091469", "class_list": "", "function": "NAD-dependent histone deacylase that acts as a regulator of life span., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F3YD73", "ec_number_list": "2.3.1.286", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0070403 NAD+ binding;GO:0004407 histone deacetylase activity;GO:0017136 histone deacetylase activity, NAD-dependent", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008340 determination of adult lifespan;GO:0031452 negative regulation of heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VH08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VH90-1", "uniprot_id": "TRBID_DROME", "mass": 88199.0, "length": 778, "protein_name": "Ubiquitin thioesterase trabid", "gene_name": "trbd", "organism": "Fruit fly", "refseq_name": "trabid", "refseq_ac": "NP_649931", "gene_names_uniprotkb": "trbd; CG9448", "gene_names_refseq": "CG9448; Dmel\\CG9448; Q9VH90; Trabid; Trbd; dTrbd; trbd", "protein_names_uniprotkb": "Ubiquitin thioesterase trabid; 3.4.19.12; dTrbd", "protein_names_refseq": "CG9448-PA; trabid; trbd-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9448); (R-DME-195253); (R-DME-5689896)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18281465;18327897", "class_list": "", "function": "Positive regulator of the Wnt signaling pathway. Specifically cleaves 'Lys-63'-linked ubiquitin chains. May act by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription (By similarity). Required for an efficient wg response, but not for other signaling responses, in the eye., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T9K1", "ec_number_list": "2.7.11.25;3.4.19.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070536 protein K63-linked deubiquitination;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0061060 negative regulation of peptidoglycan recognition protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VH90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VHF2-1", "uniprot_id": "PTER_DROME", "mass": 39297.0, "length": 350, "protein_name": "Phosphotriesterase-related protein", "gene_name": "CG18473", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_731339", "gene_names_uniprotkb": "CG18473", "gene_names_refseq": "CG18473; CG8125; Dmel\\CG18473", "protein_names_uniprotkb": "Phosphotriesterase-related protein; 3.1.-.-; Parathion hydrolase-related protein", "protein_names_refseq": "CG18473-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18473)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0141215 N-acetyltaurine hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHF2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VHG4-1", "uniprot_id": "RENR_DROME", "mass": 34421.0, "length": 320, "protein_name": "ATPase H(+)-transporting accessory protein 2", "gene_name": "ATP6AP2", "organism": "Fruit fly", "refseq_name": "ATPase H+ transporting accessory protein 2", "refseq_ac": "NP_649876", "gene_names_uniprotkb": "ATP6AP2; CG8444; VhaM8-9; VhaM8.9; VhaPRR", "gene_names_refseq": "ATP6AP2; CG8444; Dmel\\CG8444; VhaM8-9; VhaM8.9; VhaPRR; dPRR; vhaM8.9", "protein_names_uniprotkb": "ATPase H(+)-transporting accessory protein 2; Renin homolog receptor; dPRR", "protein_names_refseq": "ATP6AP2-PA; ATPase H+ transporting accessory protein 2; CG8444-PA; drosophila homologue of prorenin receptor; vacuolar H[+] ATPase M8.9 accessory subunit", "tax_id": 7227, "disease": "congenital disorder of glycosylation type IIr (Disease Ontology:DOID:0051048); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Hedera type (Disease Ontology:DOID:0060806); X-linked parkinsonism-spasticity syndrome (Disease Ontology:DOID:0112105); hypertension (Disease Ontology:DOID:10763); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (dme:Dmel_CG8444); (R-DME-2022377); (R-DME-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;20579879;20579883;23292348;26376863;29127204;29995586", "class_list": "", "function": "Multifunctional protein which functions as a transmembrane receptor in the planar cell polarity (PCP) and is involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump (PubMed:20579879, PubMed:20579883, PubMed:29127204, PubMed:29995586). As transmembrane receptor mediates fz/PCP signaling through interaction with fz and stabilizes asymmetric PCP domains through its interaction with stan (PubMed:20579879, PubMed:20579883, PubMed:23292348, PubMed:29995586). Also mediates Wnt/beta-cat signaling through interaction with fz/fz2 (PubMed:20579879, PubMed:20579883). Probably by controlling the assembly of the V-ATPase pump and thus the acidification of the endo-lysosomal system, plays a role in many neuronal processes including synapse morphology and synaptic transmission (PubMed:26376863)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Stabilizes asymmetric Planar Cell Polarity (PCP) domains through its interaction with stan., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0048749 compound eye development;GO:0050808 synapse organization;GO:0007614 short-term memory;GO:0016197 endosomal transport;GO:0007616 long-term memory", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VHG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VHQ7-1", "uniprot_id": "OR85B_DROME", "mass": 45665.0, "length": 390, "protein_name": "Odorant receptor 85b", "gene_name": "Or85b", "organism": "Fruit fly", "refseq_name": "odorant receptor 85b", "refseq_ac": "NP_524279", "gene_names_uniprotkb": "Or85b; CG11735", "gene_names_refseq": "85A.1; 85b; CG11735; DOR115; DmOR85b; DmOr85b; Dmel\\CG11735; OR85b; Or85b", "protein_names_uniprotkb": "Odorant receptor 85b", "protein_names_refseq": "CG11735-PA; Or85b-PA; odorant receptor 85b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11735)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10943836;12537572;16615896;20147286", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to 2-heptanone, amyl acetate, and butyl acetate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VHQ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VHR8-1", "uniprot_id": "DPP3_DROME", "mass": 89194.0, "length": 786, "protein_name": "Dipeptidyl peptidase 3", "gene_name": "DppIII", "organism": "Fruit fly", "refseq_name": "dipeptidyl aminopeptidase III, isoform C", "refseq_ac": "NP_731237", "gene_names_uniprotkb": "DppIII; CG7415", "gene_names_refseq": "CG7415; DPP III; DPP; Dmel\\CG7415; DppIII", "protein_names_uniprotkb": "Dipeptidyl peptidase 3; 3.4.14.4; DPP III; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III", "protein_names_refseq": "CG7415-PC; Dipeptidyl-peptidase III; DppIII-PC; dipeptidyl aminopeptidase III, isoform C; dipeptidyl aminopeptidase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7415)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11559363;12537569;12537572;12846841", "class_list": "", "function": "Degrades neuropeptide proctolin (RYLPT) by cleavage between Tyr and Leu residues., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IHE9;Q961F1", "ec_number_list": "", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VHR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VHS4-1", "uniprot_id": "OR85A_DROME", "mass": 45820.0, "length": 397, "protein_name": "Odorant receptor 85a", "gene_name": "Or85a", "organism": "Fruit fly", "refseq_name": "odorant receptor 85a", "refseq_ac": "NP_524277", "gene_names_uniprotkb": "Or85a; CG7454", "gene_names_refseq": "85A.4; 85a; CG7454; DOR31; DmOR85A; DmOr85a; Dmel\\CG7454; OR85a; Or-85a; Or85a; or85a", "protein_names_uniprotkb": "Odorant receptor 85a", "protein_names_refseq": "CG7454-PA; Or85a-PA; odorant receptor 85a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7454)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10943836;12537572;16615896", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VHS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VHS8-1", "uniprot_id": "IF4A3_DROME", "mass": 45645.0, "length": 399, "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "CG7483", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_649788", "gene_names_uniprotkb": "CG7483", "gene_names_refseq": "7483; CG7483; DmRH28; Dmel\\CG7483; EIF4AIII; anon-WO0118547.364; eIF4A-III; eIF4A3; eIF4AIII; eIF4AII; eIF4A; eIF4aIII; elF4AIII; l(3)84Fi", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-III; 3.6.4.13; eIF-4A-III; eIF4A-III", "protein_names_refseq": "CG7483-PA; eIF4AIII; eukaryotic translation initiation factor 4AIII; lethal(3)84Fi; uncharacterized protein", "tax_id": 7227, "disease": "intellectual disability (Disease Ontology:DOID:1059); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dme:Dmel_CG7483); (R-DME-159236); (R-DME-429947); (R-DME-72163); (R-DME-975957)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;12537572;14973490;20946982;20946983;22961380", "class_list": "", "function": "ATP-dependent RNA helicase (PubMed:22961380). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:22961380). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). Has a role in oskar mRNA localization at the posterior pole of the developing oocyte (PubMed:14973490)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXH3", "ec_number_list": "2.3.2.-;3.1.13.4;3.6.4.13;7.2.2.-;3.6.4.-;2.7.7.6;3.1.-.-;3.1.3.16;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.6.1.15;5.2.1.8;3.4.21.-;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0045495 pole plasm", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0008380 RNA splicing;GO:0006325 chromatin organization;GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VHS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VI74-1", "uniprot_id": "SHQ1_DROME", "mass": 69146.0, "length": 608, "protein_name": "Protein SHQ1 homolog", "gene_name": "CG10055", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_649703", "gene_names_uniprotkb": "CG10055", "gene_names_refseq": "CG10055; Dmel\\CG10055; RE52393", "protein_names_uniprotkb": "Protein SHQ1 homolog", "protein_names_refseq": "CG10055-PA; uncharacterized protein", "tax_id": 7227, "disease": "dystonia 35, childhood-onset (Disease Ontology:DOID:0060955)", "pathway": " (dme:Dmel_CG10055); (R-DME-171319)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSE2", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0022618 protein-RNA complex assembly;GO:0000493 box H/ACA snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VI74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VIM5-1", "uniprot_id": "ARPC2_DROME", "mass": 35104.0, "length": 301, "protein_name": "Actin-related protein 2/3 complex subunit 2", "gene_name": "Arpc2", "organism": "Fruit fly", "refseq_name": "Actin-related protein 2/3 complex, subunit 2, isoform B", "refseq_ac": "NP_001286102", "gene_names_uniprotkb": "Arpc2; 38C.47; ARC-P34; ARC-p34; ARPC2; Arc-p34; ArcP34; Arpc2; CG10954; Dmel\\CG10954; Dmel_CG10954; anon-WO0118547.154; arpC2; p34", "gene_names_refseq": "38C.47; ARC-P34; ARC-p34; ARPC2/p34; ARPC2; Arc-p34/Arpc2; Arc-p34; ArcP34; Arpc2; CG10954; Dmel\\CG10954; anon-WO0118547.154; arpC2; p34", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 2; Arp2/3 complex 34 kDa subunit; p34-ARC", "protein_names_refseq": "Actin-related protein 2/3 complex, subunit 2, isoform B; Arc-p34; Arpc2-PB; CG10954-PB", "tax_id": 7227, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); silicosis (Disease Ontology:DOID:10325); melanoma (Disease Ontology:DOID:1909); invasive ductal carcinoma (Disease Ontology:DOID:3008); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (dme:Dmel_CG10954); (R-DME-2029482); (R-DME-3928662); (R-DME-5663213); (R-DME-8856828)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95T07", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0045179 apical cortex;GO:0015629 actin cytoskeleton;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0008360 regulation of cell shape;GO:0030866 cortical actin cytoskeleton organization;GO:0030041 actin filament polymerization;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0030031 cell projection assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VIM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VIP2-1", "uniprot_id": "PYRD1_DROME", "mass": 52351.0, "length": 472, "protein_name": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "gene_name": "Pyroxd1", "organism": "Fruit fly", "refseq_name": "pyridine nucleotide-disulfide oxidoreductase domain 1, isoform B", "refseq_ac": "NP_001260619", "gene_names_uniprotkb": "Pyroxd1; CG10721", "gene_names_refseq": "38B.14; CG10721; Dmel\\CG10721; Pyroxd1", "protein_names_uniprotkb": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1; 1.6.99.1; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1", "protein_names_refseq": "CG10721-PB; Pyroxd1-PB; pyridine nucleotide-disulfide oxidoreductase domain 1, isoform B", "tax_id": 7227, "disease": "myofibrillar myopathy 8 (Disease Ontology:DOID:0080308)", "pathway": " (dme:Dmel_CG10721)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;30345904", "class_list": "", "function": "Flavoprotein whose role is to protect RTCB, the catalytic subunit of the tRNA ligase complex (tRNA-LC) involved in tRNA splicing and unfolded protein response, from oxidative inactivation. It directly binds and shields the catalytic center of RTCB, prior to guanylylation, when it is inactive and its active site is vulnerable to oxidation under aerobic conditions. The interaction of PYROXD1 with RTCB is allosterically regulated by NAD(P)H binding and reduction of its FAD cofactor, while reoxidation of PYROXD1 thanks to its NADPH dehydrogenase activity triggers the timed release of RTCB, enabling its subsequent activation. Thereby, this protective mechanism may also function as a molecular timer, regulating RTCB activation through controlled release., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.6.99.1;1.6.99.-;1.11.1.-;1.6.3.1", "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0003959 NADPH dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030017 sarcomere", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VIP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VIQ0-1", "uniprot_id": "SNPF_DROME", "mass": 32545.0, "length": 281, "protein_name": "Short neuropeptide F", "gene_name": "sNPF", "organism": "Fruit fly", "refseq_name": "short neuropeptide F precursor", "refseq_ac": "NP_724239", "gene_names_uniprotkb": "sNPF; CG13968", "gene_names_refseq": "38B.2; CG13968; Dmel\\CG13968; Drm-sNPF-1; Drm-sNPF-2; Drm-sNPF-3; Drm-sNPF-4; Drm-sNPF-AP1; Drm-sNPF; LRLRFamide; SNPF; lrlrfa; s-NPF; sNPF-1[4-11]; sNPF-1; sNPF-2[12-19]; sNPF-2s; sNPF-2; sNPF-3; sNPF-4; sNPF1[1-11]; sNPF1[4-11; sNPF1; sNPF2[12-19]; sNPF3; sNPF; short NPF; snpf", "protein_names_uniprotkb": "Short neuropeptide F", "protein_names_refseq": "CG13968-PB; LRLRFamides; SMALL NEUROPEPTIDE F; neuropeptide F (short); precursor of short neuropeptide F; sNPF precursor; sNPF-PB; short NPF; short neuropeptide F precursor; short neuropeptide F-1; short neuropeptide F1; small neuropeptide F-1; small neuropeptide-F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13968)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12171930;12537569;12537572;15385546;21214272", "class_list": "", "function": "Plays a role in controlling food intake and regulating body size., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5Y9D1;Q6YLS6", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0071855 neuropeptide receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0032095 regulation of response to food;GO:0007218 neuropeptide signaling pathway;GO:0040014 regulation of multicellular organism growth;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VIQ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VIT2-1", "uniprot_id": "PMVK_DROME", "mass": 22144.0, "length": 189, "protein_name": "Phosphomevalonate kinase", "gene_name": "Pmvk", "organism": "Fruit fly", "refseq_name": "phosphomevalonate kinase", "refseq_ac": "NP_609992", "gene_names_uniprotkb": "Pmvk; CG10268", "gene_names_refseq": "BcDNA:SD12705; CG10268; Dmel\\CG10268; MevPK; PMVK; Pmvk", "protein_names_uniprotkb": "Phosphomevalonate kinase; 2.7.4.2; PMKase", "protein_names_refseq": "CG10268-PA; Pmvk-PA; phosphomevalonate kinase", "tax_id": 7227, "disease": "porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (dme:Dmel_CG10268); (R-DME-9969896)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJH0;Q8MRY7", "ec_number_list": "2.7.4.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0004631 phosphomevalonate kinase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VIT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJG0-1", "uniprot_id": "XPP_DROME", "mass": 68506.0, "length": 613, "protein_name": "Xaa-Pro aminopeptidase ApepP", "gene_name": "ApepP", "organism": "Fruit fly", "refseq_name": "aminopeptidase P, isoform B", "refseq_ac": "NP_001246053", "gene_names_uniprotkb": "ApepP; CG6291", "gene_names_refseq": "AP-P; ApepP; Apep[P]; CG6291; DAP-P; Daminopep-p; Dmel\\CG6291", "protein_names_uniprotkb": "Xaa-Pro aminopeptidase ApepP; 3.4.11.9; AP-P; Aminopeptidase P", "protein_names_refseq": "ApepP-PB; CG6291-PB; aminopeptidase P, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6291)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11872174;12537569;12537572", "class_list": "", "function": "Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VJG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJI9-1", "uniprot_id": "NUBP1_DROME", "mass": 33071.0, "length": 311, "protein_name": "Cytosolic Fe-S cluster assembly factor Nubp1 homolog", "gene_name": "Nubp1", "organism": "Fruit fly", "refseq_name": "NUBP iron-sulfur cluster assembly factor 1", "refseq_ac": "NP_609805", "gene_names_uniprotkb": "Nubp1; CG17904", "gene_names_refseq": "CG17904; Dmel\\CG17904; Nbp35; Nubp1", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor Nubp1 homolog", "protein_names_refseq": "CG17904-PA; NUBP iron-sulfur cluster assembly factor 1; Nubp1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17904)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The Nubp1-Nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016887 ATP hydrolysis activity;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005829 cytosol;GO:1904564 cytosolic [4Fe-4S] assembly scaffold complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VJI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJN9-1", "uniprot_id": "SEMP1_DROME", "mass": 29282.0, "length": 251, "protein_name": "Seminal metalloprotease 1", "gene_name": "Semp1", "organism": "Fruit fly", "refseq_name": "seminal metalloprotease-1", "refseq_ac": "NP_609756", "gene_names_uniprotkb": "Semp1; CG11864", "gene_names_refseq": "AST; BACR44L22.8; BG:BACR44L22.8; CG11864; Dmel\\CG11864; Semp1; semp1", "protein_names_uniprotkb": "Seminal metalloprotease 1; 3.4.24.-", "protein_names_refseq": "CG11864-PA; Semp1-PA; seminal metalloprotease-1", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (dme:Dmel_CG11864)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15979005;17116868;24514904", "class_list": "", "function": "Seminal fluid metalloprotease which is transferred to females during mating and is required for processing of two other seminal fluid proteins Acp26Aa and Acp36DE in mated females., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZE8;S0ASJ3", "ec_number_list": "", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0006508 proteolysis;GO:0016477 cell migration;GO:0016485 protein processing;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VJN9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJP9-1", "uniprot_id": "Q9VJP9_DROME", "mass": 18841.0, "length": 162, "protein_name": "Uxt prefoldin-like subunit, isoform A; Uxt prefoldin-like subunit, isoform B", "gene_name": "Uxt", "organism": "Fruit fly", "refseq_name": "Uxt prefoldin-like subunit, isoform B", "refseq_ac": "NP_001260464", "gene_names_uniprotkb": "Uxt; BG:DS07295.5; CG15266; Dmel\\CG15266; Dmel_CG15266; br50; l(2)35Cc; l(2)br50; l35Cc; uxt", "gene_names_refseq": "BG:DS07295.5; CG15266; Dmel\\CG15266; Uxt; br50; l(2)35Cc; l(2)br50; l35Cc; uxt", "protein_names_uniprotkb": "Uxt prefoldin-like subunit, isoform A; Uxt prefoldin-like subunit, isoform B", "protein_names_refseq": "CG15266-PB; Uxt prefoldin-like subunit, isoform B; Uxt-PB; lethal (2) 35Cc", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15266)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NK93", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0000785 chromatin;GO:0016592 mediator complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VJP9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJQ4-1", "uniprot_id": "MCES_DROME", "mass": 48679.0, "length": 427, "protein_name": "mRNA cap guanine-N(7) methyltransferase", "gene_name": "Rnmt", "organism": "Fruit fly", "refseq_name": "RNA guanine-7 methyltransferase", "refseq_ac": "NP_523568", "gene_names_uniprotkb": "Rnmt; CG3688; br9; l(2)br9", "gene_names_refseq": "BG:DS00929.5; C2; CG3688; Dmel\\CG3688; RNA-guanine-7-methyltransferase; Rnmt; br9; l(2)10408; l(2)35Bd; l(2)br9", "protein_names_uniprotkb": "mRNA cap guanine-N(7) methyltransferase; 2.1.1.56; mRNA (guanine-N(7))-methyltransferase", "protein_names_refseq": "CG3688-PA; RNA (guanine-7-)methyltransferase; RNA guanine-7 methyltransferase; Rnmt-PA; lethal (2) 35Bd; lethal 9 in the black-reduced region; lethal group C2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3688); (R-DME-72086); (R-DME-77075)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9N6X4", "ec_number_list": "2.7.7.6;5.6.2.4;2.7.11.22;2.7.11.23;5.6.2.3;2.1.1.56", "go_molecular_function": "GO:0003723 RNA binding;GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VJQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJS7-1", "uniprot_id": "PBURS_DROME", "mass": 16049.0, "length": 141, "protein_name": "Protein partner of bursicon", "gene_name": "Pburs", "organism": "Fruit fly", "refseq_name": "partner of bursicon", "refseq_ac": "NP_609712", "gene_names_uniprotkb": "Pburs; CG15284; burs-beta", "gene_names_refseq": "A; Bur beta; Burs beta; Bursbeta; CG15284; Dmel\\CG15284; PBURS; Pburs; burs beta; burs-beta; bursbeta; pads-b; pburs; pup; pu", "protein_names_uniprotkb": "Protein partner of bursicon; Bursicon subunit beta; burs beta", "protein_names_refseq": "CG15284-PA; Pburs-PA; bursicon beta subunit; bursicon beta-subunit; bursicon beta; lethal group A; partner of bursicon; partner of burs; partner-of-bursicon; pupal", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15284)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;15703293;15811337;18784295", "class_list": "", "function": "Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4G7E2", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031395 bursicon neuropeptide hormone complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007593 chitin-based cuticle sclerotization;GO:0018990 ecdysis, chitin-based cuticle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VJS7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJS8-3", "uniprot_id": "ELBOW_DROME", "mass": 55876.0, "length": 553, "protein_name": "Zinc finger protein Elbow", "gene_name": "elB", "organism": "Fruit fly", "refseq_name": "elbow B, isoform D", "refseq_ac": "NP_523566", "gene_names_uniprotkb": "elB; CG4220", "gene_names_refseq": "BG:DS06238.3; CG4220; Dmel\\CG4220; ElB; Elbow; Elb; P10; elB; el[B]; elbow; elb; el", "protein_names_uniprotkb": "Zinc finger protein Elbow", "protein_names_refseq": "CG4220-PD; ElbowB; elB-PD; elbow B, isoform D; elbow B; elbow", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4220)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12117809;12537572;14757638;17014842", "class_list": "", "function": "May negatively regulate Notch-induced cell proliferation in the eye-head primordium. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Required for tracheal development., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7KT93;Q8IGL9;Q8MTC6;Q9NKC3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription;GO:0035214 eye-antennal disc development;GO:0001752 compound eye photoreceptor fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VJS8-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VJY6-1", "uniprot_id": "RL24_DROME", "mass": 17520.0, "length": 155, "protein_name": "Large ribosomal subunit protein eL24", "gene_name": "RpL24", "organism": "Fruit fly", "refseq_name": "ribosomal protein L24, isoform B", "refseq_ac": "NP_001285895", "gene_names_uniprotkb": "RpL24; CG9282; Dmel\\CG9282; Dmel_CG9282; L24e; L24; RL24_DROME; Rp L24; Rpl24; anon-EST:Posey242; anon-EST:Posey37", "gene_names_refseq": "CG9282; Dmel\\CG9282; L24e; L24; RL24_DROME; Rp L24; RpL24; Rpl24; anon-EST:Posey242; anon-EST:Posey37", "protein_names_uniprotkb": "Large ribosomal subunit protein eL24; 60S ribosomal protein L24", "protein_names_refseq": "CG9282-PB; RpL24-PB; ribosomal protein L24, isoform B; ribosomal protein L24", "tax_id": 7227, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (dme:Dmel_CG9282); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23636399;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VJY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VK34-1", "uniprot_id": "SIRT1_DROME", "mass": 91837.0, "length": 823, "protein_name": "NAD-dependent histone deacetylase sirtuin-1", "gene_name": "Sirt1", "organism": "Fruit fly", "refseq_name": "sirtuin 1", "refseq_ac": "NP_477351", "gene_names_uniprotkb": "Sirt1; CG5216; Sir2", "gene_names_refseq": "BEST:LD38188; CG5216; D.mel1; DSir2; Dmel\\CG5216; SIR-2; SIR2; SIRT1; Sir2L; Sir2; Sirt1/dSir2; Sirt1; dSIR2; dSir2; dmSRT406; dsir2; l(2)05326; sir2; sirt1", "protein_names_uniprotkb": "NAD-dependent histone deacetylase sirtuin-1; 2.3.1.286; Silent information regulator 2", "protein_names_refseq": "CG5216-PA; Sir2; Sirt1-PA; silent information regulator 2; sirtuin 1; sirtuin 2", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); macular degeneration (Disease Ontology:DOID:4448); myocardial infarction (Disease Ontology:DOID:5844); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG5216); (R-DME-427359); (R-DME-9617629); (R-DME-9841922); (R-DME-9856649)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10731132;11281647;12086602;12537572;12663533;15498488;15520384;17159295;18327897", "class_list": "", "function": "NAD-dependent histone deacetylase involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4 deacetylase activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D5SHQ6;O96505", "ec_number_list": "2.3.1.48;2.1.1.355;2.7.11.22;2.1.1.-;3.5.1.98;2.3.1.286", "go_molecular_function": "GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0070403 NAD+ binding;GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0033553 rDNA heterochromatin;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0046331 lateral inhibition;GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0032869 cellular response to insulin stimulus;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VK34-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKA4-3", "uniprot_id": "Y1760_DROME", "mass": 121584.0, "length": 1093, "protein_name": "Probable G protein-coupled receptor CG31760", "gene_name": "CG31760", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001162962", "gene_names_uniprotkb": "CG31760", "gene_names_refseq": "BcDNA:RE52162; CG17214; CG17215; CG31760; Dmel\\CG31760", "protein_names_uniprotkb": "Probable G protein-coupled receptor CG31760", "protein_names_refseq": "CG31760-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "congenital stationary night blindness 1E (Disease Ontology:DOID:0110869)", "pathway": " (dme:Dmel_CG31760)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;17372656", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E1JHG5;Q8MT43", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VKA4-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKD6-1", "uniprot_id": "DGT2_DROME", "mass": 25845.0, "length": 231, "protein_name": "Augmin complex subunit dgt2", "gene_name": "dgt2", "organism": "Fruit fly", "refseq_name": "dim gamma-tubulin 2, isoform B", "refseq_ac": "NP_001285856", "gene_names_uniprotkb": "dgt2; CG16969", "gene_names_refseq": "CG16969; Dgt2; Dmel\\CG16969; dgt2", "protein_names_uniprotkb": "Augmin complex subunit dgt2; Dim gamma-tubulin 2", "protein_names_refseq": "CG16969-PB; dgt2-PB; dim gamma-tubulin 2, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16969)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;17412918;18443220;19289792;19369198;23785300", "class_list": "", "function": "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:18443220). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:17412918). dgt2 binds to microtubules in vitro (PubMed:19289792)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005819 spindle;GO:0005874 microtubule;GO:0072687 meiotic spindle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VKD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKH6-1", "uniprot_id": "PPT2_DROME", "mass": 32619.0, "length": 288, "protein_name": "Lysosomal thioesterase PPT2 homolog", "gene_name": "Ppt2", "organism": "Fruit fly", "refseq_name": "Palmitoyl-protein thioesterase 2", "refseq_ac": "NP_609500", "gene_names_uniprotkb": "Ppt2; CG4851", "gene_names_refseq": "CG4851; Dmel\\CG4851; PPT-2; Ppt2", "protein_names_uniprotkb": "Lysosomal thioesterase PPT2 homolog; 3.1.2.2; PPT-2", "protein_names_refseq": "CG4851-PA; Palmitoyl-protein thioesterase 2; Ppt2-PA", "tax_id": 7227, "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)", "pathway": " (dme:Dmel_CG4851); (R-DME-75105)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18719403", "class_list": "", "function": "Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95SL2", "ec_number_list": "3.1.2.2", "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0016790 thiolester hydrolase activity;GO:0098599 palmitoyl hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VKH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKJ3-1", "uniprot_id": "NU160_DROME", "mass": 160276.0, "length": 1411, "protein_name": "Nuclear pore complex protein Nup160 homolog", "gene_name": "Nup160", "organism": "Fruit fly", "refseq_name": "nucleoporin 160kD, isoform B", "refseq_ac": "NP_001285832", "gene_names_uniprotkb": "Nup160; CG4738; Dmel\\CG4738; Dmel_CG4738; Nup160[mel]; Nup; l(2)SH2 2055; l(2)SH2055; nup160", "gene_names_refseq": "CG4738; Dmel\\CG4738; Nup160[mel]; Nup160; Nup; l(2)SH2 2055; l(2)SH2055; nup160", "protein_names_uniprotkb": "Nuclear pore complex protein Nup160 homolog; Nuclear pore protein 160", "protein_names_refseq": "CG4738-PB; Nup160-PB; lethal (2) SH2055; nuclear pore protein 160; nucleoporin 160kD, isoform B; nucleoporin 160", "tax_id": 7227, "disease": "nephrotic syndrome type 19 (Disease Ontology:DOID:0080394)", "pathway": " (dme:Dmel_CG4738); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;19197064;20547758;25589440;26109356;26109357;26502056;30910934", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC) (PubMed:19197064). Involved in poly(A)+ RNA transport (By similarity). Required for nuclear import of Mad (PubMed:20547758). May play a role in double strand break DNA repair (PubMed:26502056). Essential for nephrocyte development (PubMed:30910934)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0KG65;C0KG66;C0KG67;C0KG68;C0KG69;C0KG70;C0KG71;C0KG74;C0KG75;Q6AWI7", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0046822 regulation of nucleocytoplasmic transport;GO:0006974 DNA damage response;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VKJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKK1-1", "uniprot_id": "EDC4_DROME", "mass": 149251.0, "length": 1354, "protein_name": "Enhancer of mRNA-decapping protein 4 homolog", "gene_name": "Ge-1", "organism": "Fruit fly", "refseq_name": "Ge-1, isoform A", "refseq_ac": "NP_609486", "gene_names_uniprotkb": "Ge-1; CG6181", "gene_names_refseq": "CG6181; Dmel\\CG6181; EDC4; GE-1; Ge-1; Ref(2)Me; dGe-1; ref(2)M", "protein_names_uniprotkb": "Enhancer of mRNA-decapping protein 4 homolog", "protein_names_refseq": "CG6181-PA; Ge-1 ortholog; Ge-1, isoform A; Ge-1-PA; refractory to sigma M", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6181); (R-DME-430039)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;17372656;17901217;18327897;18755833;31114929;33925313", "class_list": "", "function": "In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZ42", "ec_number_list": "", "go_molecular_function": "GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0000932 P-body;GO:0045495 pole plasm", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006402 mRNA catabolic process;GO:0035195 miRNA-mediated post-transcriptional gene silencing;GO:0033962 P-body assembly;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VKK1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKK2-1", "uniprot_id": "WDR59_DROME", "mass": 107969.0, "length": 969, "protein_name": "GATOR2 complex protein Wdr59", "gene_name": "Wdr59", "organism": "Fruit fly", "refseq_name": "WD repeat domain 59, isoform D", "refseq_ac": "NP_609485", "gene_names_uniprotkb": "Wdr59; CG4705", "gene_names_refseq": "CG4705; Dmel\\CG4705; FBtr0080196; GATOR2; SEA3; Sea3; WDR59; Wdr59; wdr59; wdr5", "protein_names_uniprotkb": "GATOR2 complex protein Wdr59", "protein_names_refseq": "CG4705-PD; WD repeat domain 59, isoform D; Wdr59-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4705)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;18327897;23723238;27166823;36577058;38514639", "class_list": "", "function": "A component of the GATOR complex, which functions as a regulator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:36577058). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the mTORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:36577058). GATOR2 activates the mTORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:23723238). Acts as an atypical component of the GATOR2 subcomplex, which can either promote or inhibit mTORC1 signaling, depending on tissues: inhibits mTORC1 activity by preventing the activity of GATOR2 in the ovary and the eye imaginal disk brain, while it promotes mTORC1 activity in the fat body (PubMed:36577058)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RIT6;Q7KTE5;Q8T9F8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0061700 GATOR2 complex;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032008 positive regulation of TOR signaling;GO:0034198 cellular response to amino acid starvation;GO:1904262 negative regulation of TORC1 signaling;GO:1903432 regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VKK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKM6-1", "uniprot_id": "VPS72_DROME", "mass": 40442.0, "length": 351, "protein_name": "Vacuolar protein sorting-associated protein 72 homolog", "gene_name": "YL-1", "organism": "Fruit fly", "refseq_name": "YL-1, isoform B", "refseq_ac": "NP_001285823", "gene_names_uniprotkb": "YL-1; CG4621; Dmel\\CG4621; Dmel_CG4621; YL1; dYL-1; dYL1", "gene_names_refseq": "CG4621; Dmel\\CG4621; YL-1; YL1; dYL-1; dYL1", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 72 homolog; Protein YL-1", "protein_names_refseq": "CG4621-PB; YL-1, isoform B; YL-1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4621)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15528408;16110336;16299513;17569856;17569867;18327897;25589440;26109356;26109357;32432549", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:15528408, PubMed:16299513)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0045893 positive regulation of DNA-templated transcription;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VKM6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKN7-1", "uniprot_id": "AURKB_DROME", "mass": 38301.0, "length": 329, "protein_name": "Aurora kinase B", "gene_name": "aurB", "organism": "Fruit fly", "refseq_name": "aurora B", "refseq_ac": "NP_477336", "gene_names_uniprotkb": "aurB; CG6620; ial", "gene_names_refseq": "ABK; AURKB; Aur B; AurB; Aurora B; Aurora-B; Aur; CG6620; DmAIRK2; DmAurB; DmAuroraB; Dmel\\CG6620; IAL1; IAL; Ial; aurB; ial/AurB; ial", "protein_names_uniprotkb": "Aurora kinase B; 2.7.11.1; IPL1/Aurora-like protein kinase; Serine/threonine-protein kinase Ial; Serine/threonine-protein kinase aurora-B", "protein_names_refseq": "AURORA-like; CG6620-PA; DmAuroraB; IplI-aurora-like kinase; aurB-PA; aurora B kinase; aurora B; aurora-B; auroraB; dAurora B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6620); (R-DME-174178); (R-DME-4615885); (R-DME-6804756)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10231582;10433558;10731132;11266459;11352945;12374737;12537569;12537572;16824953;25647097", "class_list": "", "function": "Serine/threonine-protein kinase that mediates both meiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation. Phosphorylates mei-S332 within residues 124-126 and stabilizes its association with centromeres during meiosis. May regulate the function of the ESCRT-III complex core component shrb during abscission of germline cells in oogenesis (PubMed:25647097)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9XTQ0", "ec_number_list": "2.3.2.-;2.7.11.17;2.7.11.1;2.7.11.13;2.7.11.24;2.7.11.22;2.7.11.21;5.6.1.8;2.7.11.11;2.7.11.23;2.3.2.23;2.7.12.1;2.7.11.25;2.7.11.12;2.7.12.2;2.7.10.2;3.4.19.-;5.6.1.5;3.4.21.-;2.3.2.24;2.7.11.39", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005819 spindle;GO:0051233 spindle midzone", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0007076 mitotic chromosome condensation;GO:0006325 chromatin organization;GO:0000281 mitotic cytokinesis;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9VKN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKQ6-1", "uniprot_id": "SMG8_DROME", "mass": 106828.0, "length": 944, "protein_name": "Nonsense-mediated mRNA decay factor SMG8", "gene_name": "CG6729", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_609449", "gene_names_uniprotkb": "CG6729", "gene_names_refseq": "CG6729; Dmel\\CG6729", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor SMG8; Protein smg-8 homolog", "protein_names_refseq": "CG6729-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6729); (R-DME-975957)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing nonC and recruited to stalled ribosomes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RIT4;Q8T4F6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VKQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKQ9-1", "uniprot_id": "DPY30_DROME", "mass": 13794.0, "length": 134, "protein_name": "Protein dpy-30 homolog", "gene_name": "Dpy-30L1", "organism": "Fruit fly", "refseq_name": "Dpy-30-like 1", "refseq_ac": "NP_609445", "gene_names_uniprotkb": "Dpy-30L1; CG6444", "gene_names_refseq": "CG6444; DPY30; Dmel\\CG6444; Dpy-30L1; Dpy30; dDPY30-L1; dpy-30L1; dpy30", "protein_names_uniprotkb": "Protein dpy-30 homolog; Dpy-30-like protein 1", "protein_names_refseq": "CG6444-PA; Dpy-30-like 1; Dpy-30L1-PA; Dumpy-30-like 1", "tax_id": 7227, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dme:Dmel_CG6444)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;18588663;21694722;21875999", "class_list": "", "function": "Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. Inhibits MTF-1 transcription factor activity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DMX8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0044666 MLL3/4 complex;GO:0048188 Set1C/COMPASS complex;GO:0044665 MLL1/2 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VKQ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VKW3-1", "uniprot_id": "Q9VKW3_DROME", "mass": 37408.0, "length": 332, "protein_name": "Activator 1 subunit 5", "gene_name": "RfC3", "organism": "Fruit fly", "refseq_name": "replication factor C subunit 3", "refseq_ac": "NP_609399", "gene_names_uniprotkb": "RfC3; CG5313; DRFC; DmRFC3; Dmel\\CG5313; Dmel_CG5313; Rfc3; rfc3", "gene_names_refseq": "CG5313; DRFC; DmRFC3; Dmel\\CG5313; RfC3; Rfc3; rfc3", "protein_names_uniprotkb": "Activator 1 subunit 5", "protein_names_refseq": "CG5313-PA; RfC3-PA; drosophila replication factor C; replication factor C subunit 3", "tax_id": 7227, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (dme:Dmel_CG5313); (R-DME-110312); (R-DME-110314); (R-DME-110320); (R-DME-174411); (R-DME-176187); (R-DME-5651801); (R-DME-5655862); (R-DME-5656121); (R-DME-5656169); (R-DME-5696397); (R-DME-5696400); (R-DME-6782135); (R-DME-6782210); (R-DME-69091)", "pathway_count": 15, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NGN8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:0006272 leading strand elongation;GO:0006281 DNA repair;GO:0007062 sister chromatid cohesion;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VKW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VL14-1", "uniprot_id": "RTBP_DROME", "mass": 13852.0, "length": 118, "protein_name": "REPTOR-binding partner", "gene_name": "REPTOR-BP", "organism": "Fruit fly", "refseq_name": "REPTOR-binding partner, isoform A", "refseq_ac": "NP_609363", "gene_names_uniprotkb": "REPTOR-BP; CG18619", "gene_names_refseq": "BcDNA:RH73910; CG18619; DM20; Dmel\\CG18619; REPTOR-BP; Reptor-BP", "protein_names_uniprotkb": "REPTOR-binding partner", "protein_names_refseq": "CG18619-PA; REPTOR-BP-PA; REPTOR-binding partner, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18619)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;25920570", "class_list": "", "function": "Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation. Interacts with REPTOR to form a transcriptional activator complex that functions downstream of TORC1 to up-regulate the expression of most target genes induced by TORC1 inhibition. In the complex, acts to enhance the binding of the transcriptional activator REPTOR to the regulatory sequences of target genes. Under normal conditions TORC1 is active, inhibiting the formation of the REPTOR/REPTOR-BP complex by phosphorylating REPTOR and mediates its cytoplasmic retention by forming a docking site for 14-3-3 proteins. Upon TORC1 inhibition resulting from nutrient stress, REPTOR is recruited into the nucleus where it interacts with REPTOR-BP and together they maintain organismal metabolism by activating the expression of target stress response genes including those involved in glycogenesis and triglyceride biosynthesis. The complex also appears to negatively regulate some aspects of TORC1-dependent larval growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IPC6;Q8IPC7;Q8MYS1", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042594 response to starvation;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VL14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VL72-1", "uniprot_id": "SMRCD_DROME", "mass": 95447.0, "length": 844, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog", "gene_name": "Etl1", "organism": "Fruit fly", "refseq_name": "Etl1", "refseq_ac": "NP_609320", "gene_names_uniprotkb": "Etl1; CG5899", "gene_names_refseq": "CG5899; Dmel\\CG5899; ETL1; Etl1; SMARCAD1", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog; 3.6.4.-; Enhancer trap locus homolog 1; Etl-1", "protein_names_refseq": "CG5899-PA; Etl1 homologue; Etl1-PA; Etl1", "tax_id": 7227, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); BASAN syndrome (Disease Ontology:DOID:0080725); adermatoglyphia (Disease Ontology:DOID:0111357)", "pathway": " (dme:Dmel_CG5899)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2PDU7;Q95ST4", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140750 nucleosome array spacer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050829 defense response to Gram-negative bacterium;GO:0000729 DNA double-strand break processing;GO:0045089 positive regulation of innate immune response;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VL72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VL86-1", "uniprot_id": "CBPA1_DROME", "mass": 47661.0, "length": 430, "protein_name": "Zinc carboxypeptidase A 1", "gene_name": "CG17633", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_609310", "gene_names_uniprotkb": "CG17633", "gene_names_refseq": "CG17633; Dmel\\CG17633", "protein_names_uniprotkb": "Zinc carboxypeptidase A 1; 3.4.17.-", "protein_names_refseq": "CG17633-PA; uncharacterized protein", "tax_id": 7227, "disease": "familial temporal lobe epilepsy 5 (Disease Ontology:DOID:0060752); familial febrile seizures 11 (Disease Ontology:DOID:0111308); nephrotic syndrome (Disease Ontology:DOID:1184); Behcet's disease (Disease Ontology:DOID:13241); thrombocytosis (Disease Ontology:DOID:2228); pancreatitis (Disease Ontology:DOID:4989); chronic kidney disease (Disease Ontology:DOID:784); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG17633)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZP6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VL86-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLK2-1", "uniprot_id": "Y3096_DROME", "mass": 74364.0, "length": 681, "protein_name": "Ribosomal L1 domain-containing protein CG13096", "gene_name": "CG13096", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001285757", "gene_names_uniprotkb": "CG13096", "gene_names_refseq": "CG13096; Dmel\\CG13096; UTP30", "protein_names_uniprotkb": "Ribosomal L1 domain-containing protein CG13096", "protein_names_refseq": "CG13096-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13096)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17372656;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T9F1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VLK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLM8-1", "uniprot_id": "SYAC_DROME", "mass": 107741.0, "length": 966, "protein_name": "Alanine--tRNA ligase, cytoplasmic", "gene_name": "AlaRS", "organism": "Fruit fly", "refseq_name": "Alanyl-tRNA synthetase, isoform A", "refseq_ac": "NP_523511", "gene_names_uniprotkb": "AlaRS; Aats-ala; CG13391; alaS", "gene_names_refseq": "AARS; ARS; Aats-ala; AlaRS; CG13391; Dmel\\CG13391; alaS; dAARS", "protein_names_uniprotkb": "Alanine--tRNA ligase, cytoplasmic; 6.1.1.7; AlaRS; Alanyl-tRNA synthetase", "protein_names_refseq": "AlaRS-PA; Alanyl-tRNA synthetase, isoform A; CG13391-PA", "tax_id": 7227, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); nonphotosensitive trichothiodystrophy 8 (Disease Ontology:DOID:0061023); developmental and epileptic encephalopathy 29 (Disease Ontology:DOID:0080451); Charcot-Marie-Tooth disease axonal type 2N (Disease Ontology:DOID:0110177); dermatomyositis (Disease Ontology:DOID:10223); leukodystrophy (Disease Ontology:DOID:10579); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); microcephaly (Disease Ontology:DOID:10907); axonal neuropathy (Disease Ontology:DOID:7319)", "pathway": " (dme:Dmel_CG13391)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11035802;12537569;12537572", "class_list": "", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T9K4;Q9U6B4", "ec_number_list": "6.1.1.7", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004813 alanine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006419 alanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VLM8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLP4-1", "uniprot_id": "MTSH_DROME", "mass": 73680.0, "length": 649, "protein_name": "Protein mitoshell", "gene_name": "mtsh", "organism": "Fruit fly", "refseq_name": "mitoshell, isoform D", "refseq_ac": "NP_609208", "gene_names_uniprotkb": "mtsh; CG7795", "gene_names_refseq": "CG7795; Dmel\\CG7795; mtsh", "protein_names_uniprotkb": "Protein mitoshell", "protein_names_refseq": "CG7795-PD; mitoshell, isoform D; mtsh-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7795)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;20491580", "class_list": "", "function": "Required for male meiotic cytokinesis through its involvement in the regulation of mitochondrial aggregation and fusion, astral spindle assembly and contractile ring formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VLP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLQ1-1", "uniprot_id": "ALG5_DROME", "mass": 37081.0, "length": 326, "protein_name": "Dolichyl-phosphate beta-glucosyltransferase", "gene_name": "wol", "organism": "Fruit fly", "refseq_name": "wollknaeuel", "refseq_ac": "NP_609202", "gene_names_uniprotkb": "wol; CG7870; alg5", "gene_names_refseq": "ALG5; Alg5; CG7870; Dmel\\CG7870; Wol; alg5; dAlg5; wol", "protein_names_uniprotkb": "Dolichyl-phosphate beta-glucosyltransferase; 2.4.1.117; Wollknaeuel", "protein_names_refseq": "CG7870-PA; wol-PA; wollknaeuel; wollknauel", "tax_id": 7227, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); polycystic kidney disease 7 (Disease Ontology:DOID:0060952)", "pathway": " (dme:Dmel_CG7870); (R-DME-480985)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18403407;21199819", "class_list": "", "function": "Required for normal production of N-glycosylated proteins in the endoplasmic reticulum (ER). Required for embryonic segmentation, dorsal-ventral patterning and gastrulation. Required for chitin orientation and shaping of the apical and lateral plasma membranes of epidermal cells during cuticle differentiation. Also required for correctly shaping apical membrane topology of the epithelia of other organs such as the midgut and the hindgut., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.117", "go_molecular_function": "GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0007379 segment specification;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VLQ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLU5-1", "uniprot_id": "WWOX_DROME", "mass": 46511.0, "length": 409, "protein_name": "WW domain-containing oxidoreductase", "gene_name": "Wwox", "organism": "Fruit fly", "refseq_name": "WW domain containing oxidoreductase, isoform B", "refseq_ac": "NP_001285735", "gene_names_uniprotkb": "Wwox; CG7221; DmWWOX; Dmel\\CG7221; Dmel_CG7221; WWOX; anon-EST:Posey177", "gene_names_refseq": "CG7221; DmWWOX; Dmel\\CG7221; WWOX; Wwox; anon-EST:Posey177", "protein_names_uniprotkb": "WW domain-containing oxidoreductase; 1.1.1.-", "protein_names_refseq": "CG7221-PB; WW domain containing oxidoreductase, isoform B; Wwox-PB", "tax_id": 7227, "disease": "autosomal recessive spinocerebellar ataxia 12 (Disease Ontology:DOID:0080060); developmental and epileptic encephalopathy 28 (Disease Ontology:DOID:0080452); Leber congenital amaurosis (Disease Ontology:DOID:14791); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dme:Dmel_CG7221); (R-DME-1251985); (R-DME-8866904); (R-DME-8866907)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16007179;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;1.1.1.-", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005764 lysosome", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0006915 apoptotic process;GO:0010212 response to ionizing radiation;GO:0016055 Wnt signaling pathway;GO:2000377 regulation of reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VLU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VLZ7-1", "uniprot_id": "C4D21_DROME", "mass": 58265.0, "length": 511, "protein_name": "Probable cytochrome P450 4d21", "gene_name": "Cyp4d21", "organism": "Fruit fly", "refseq_name": "cytochrome P450 4d21", "refseq_ac": "NP_609129", "gene_names_uniprotkb": "Cyp4d21; CG6730", "gene_names_refseq": "4d21; CG6730; CYP4d21; Cyp4d21; Dmel\\CG6730; cyp4d21; sxe1", "protein_names_uniprotkb": "Probable cytochrome P450 4d21; 1.14.-.-; CYPIVD21", "protein_names_refseq": "CG6730-PA; Cyp4d21-PA; cytochrome P450 4d21; cytochrome P450; sex-specific enzyme 1", "tax_id": 7227, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861)", "pathway": " (dme:Dmel_CG6730); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VLZ7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VM17-1", "uniprot_id": "SOSSB_DROME", "mass": 20954.0, "length": 204, "protein_name": "SOSS complex subunit B homolog", "gene_name": "CG5181", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_609115", "gene_names_uniprotkb": "CG5181", "gene_names_refseq": "CC24; CG5181; Dmel\\CG5181", "protein_names_uniprotkb": "SOSS complex subunit B homolog", "protein_names_refseq": "CG5181-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5181); (R-DME-6807505)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0070876 SOSS complex", "go_biological_process": "GO:0006281 DNA repair;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VM17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VM60-1", "uniprot_id": "MCMBP_DROME", "mass": 68017.0, "length": 605, "protein_name": "Mini-chromosome maintenance complex-binding protein", "gene_name": "CG3430", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_542438", "gene_names_uniprotkb": "CG3430", "gene_names_refseq": "CG3430; Dmel\\CG3430", "protein_names_uniprotkb": "Mini-chromosome maintenance complex-binding protein; MCM-BP; MCM-binding protein", "protein_names_refseq": "CG3430-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3430)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0051301 cell division;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VM60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VM91-1", "uniprot_id": "TTL3A_DROME", "mass": 112256.0, "length": 992, "protein_name": "Tubulin glycylase 3A", "gene_name": "TTLL3A", "organism": "Fruit fly", "refseq_name": "tubulin tyrosine ligase-like 3A", "refseq_ac": "NP_609069", "gene_names_uniprotkb": "TTLL3A; CG11323", "gene_names_refseq": "CG11323; DmCG11323; Dmel\\CG11323; TTLL3A; TTLL3; dmTTLL3A", "protein_names_uniprotkb": "Tubulin glycylase 3A; 6.3.2.-; dmTTLL3A", "protein_names_refseq": "CG11323-PA; TTLL3A-PA; tubulin tyrosine ligase-like 3A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11323)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;19524510", "class_list": "", "function": "Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0070735 protein-glycine ligase activity;GO:0070736 protein-glycine ligase activity, initiating;GO:0070737 protein-glycine ligase activity, elongating", "go_cellular_component": "GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0035082 axoneme assembly;GO:0018094 protein polyglycylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VM91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VM92-1", "uniprot_id": "TTL3B_DROME", "mass": 86109.0, "length": 756, "protein_name": "Tubulin glycylase 3B", "gene_name": "TTLL3B", "organism": "Fruit fly", "refseq_name": "tubulin tyrosine ligase-like 3B", "refseq_ac": "NP_609068", "gene_names_uniprotkb": "TTLL3B; CG11201", "gene_names_refseq": "CG11201; DmCG11201; Dmel\\CG11201; TTLL3B; TTLL3; dmTTLL3B", "protein_names_uniprotkb": "Tubulin glycylase 3B; 6.3.2.-; dmTTLL3B", "protein_names_refseq": "CG11201-PB; TTLL3B-PB; tubulin tyrosine ligase-like 3B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11201)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;19524510", "class_list": "", "function": "Essential glycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates alpha-tubulin by adding a single glycine chain to generate monoglycine side chains, but is not involved in elongation step to generate polyglycine side chains on alpha-tubulin. Has the ability to both mono- and polyglycylate non-tubulin proteins such as up (Troponin T). Required for early steps of spermatogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BHY1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0070735 protein-glycine ligase activity;GO:0070736 protein-glycine ligase activity, initiating;GO:0070737 protein-glycine ligase activity, elongating", "go_cellular_component": "GO:0005634 nucleus;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0005930 axoneme", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:0035082 axoneme assembly;GO:0018094 protein polyglycylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VM92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMD9-1", "uniprot_id": "TIG_DROME", "mass": 257446.0, "length": 2188, "protein_name": "Tiggrin", "gene_name": "Tig", "organism": "Fruit fly", "refseq_name": "tiggrin, isoform B", "refseq_ac": "NP_001285670", "gene_names_uniprotkb": "Tig; CG11527; CT36389; Dmel\\CG11527; Dmel_CG11527; TIG; tig", "gene_names_refseq": "CG11527; CT36389; Dmel\\CG11527; TIG; Tig; tig", "protein_names_uniprotkb": "Tiggrin", "protein_names_refseq": "CG11527-PB; Tig-PB; tiggrin, isoform B; tiggrin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11527)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10731132;11034900;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18835818;20371600;25589440;26109356;26109357;33925313;40245499;7924982;9521906;9660786", "class_list": "", "function": "Functions as a ligand for integrin alpha-PS2/beta-PS. Required in larvae for proper muscle structure and function. Involved in the regulation of cell adhesion during wing development., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q23984;Q6NR23", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0033627 cell adhesion mediated by integrin;GO:0034446 substrate adhesion-dependent cell spreading;GO:0007411 axon guidance;GO:0031589 cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9VMD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMN5-1", "uniprot_id": "CH60C_DROME", "mass": 61587.0, "length": 576, "protein_name": "60 kDa heat shock protein homolog 2, mitochondrial", "gene_name": "Hsp60C", "organism": "Fruit fly", "refseq_name": "heat shock protein 60C, isoform C", "refseq_ac": "NP_608948", "gene_names_uniprotkb": "Hsp60C; CG7235", "gene_names_refseq": "A4V087_DROME; CG7235; Dm25E; Dmel\\CG7235; HSP60C; Hsp60C; Hsp60; Hsp64; Q9VMN5; bs36d10.y1; hsp60C; hsp60c", "protein_names_uniprotkb": "60 kDa heat shock protein homolog 2, mitochondrial; 60 kDa chaperonin; CPN60; HSP-60; Heat shock protein 60; Hsp60", "protein_names_refseq": "60 kDa heat shock protein homolog 2 mitochondrial; CG7235-PC; Hsp60C-PC; heat shock protein 60C, isoform C", "tax_id": 7227, "disease": "hypomyelinating leukodystrophy 4 (Disease Ontology:DOID:0060789); hereditary spastic paraplegia 13 (Disease Ontology:DOID:0110766); glucose intolerance (Disease Ontology:DOID:10603); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); varicocele (Disease Ontology:DOID:12337); autistic disorder (Disease Ontology:DOID:12849); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); arteriosclerosis (Disease Ontology:DOID:2349); hereditary spastic paraplegia (Disease Ontology:DOID:2476); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); aphthous stomatitis (Disease Ontology:DOID:9663)", "pathway": " (dme:Dmel_CG7235)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;16385159", "class_list": "", "function": "Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). Essential for proper development of trachea, spermatogonia and spermatocytes., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V087;Q8IHD0;Q8MZB0", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0007283 spermatogenesis;GO:0006457 protein folding;GO:0008637 apoptotic mitochondrial changes;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VMN5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMS8-1", "uniprot_id": "C4AC2_DROME", "mass": 59708.0, "length": 511, "protein_name": "Probable cytochrome P450 4ac2", "gene_name": "Cyp4ac2", "organism": "Fruit fly", "refseq_name": "cytochrome P450 4ac2", "refseq_ac": "NP_608917", "gene_names_uniprotkb": "Cyp4ac2; CG17970", "gene_names_refseq": "4ac2; CG17970; CYP4AC2; CYP4ac2; Cyp4ac2; Dmel\\CG17970", "protein_names_uniprotkb": "Probable cytochrome P450 4ac2; 1.14.-.-; CYPIVAC2", "protein_names_refseq": "CG17970-PB; Cyp4ac2-PB; cytochrome P450 4ac2; cytochrome P450", "tax_id": 7227, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664)", "pathway": " (dme:Dmel_CG17970); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V4C1", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VMS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMT6-1", "uniprot_id": "C28D2_DROME", "mass": 58222.0, "length": 501, "protein_name": "Probable cytochrome P450 28d2", "gene_name": "Cyp28d2", "organism": "Fruit fly", "refseq_name": "cytochrome P450 28d2", "refseq_ac": "NP_608911", "gene_names_uniprotkb": "Cyp28d2; CG6081", "gene_names_refseq": "28d2; CG6081; CYP28D2; Cyp28D2; Cyp28d2; Dmel\\CG6081", "protein_names_uniprotkb": "Probable cytochrome P450 28d2; 1.14.-.-; CYPXXVIIID2", "protein_names_refseq": "CG6081-PA; Cyp28d2-PA; cytochrome P450 28d2; cytochrome P450", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6081)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VMT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMU8-1", "uniprot_id": "SENJU_DROME", "mass": 43616.0, "length": 388, "protein_name": "UDP-galactose transporter senju", "gene_name": "senju", "organism": "Fruit fly", "refseq_name": "senju", "refseq_ac": "NP_608902", "gene_names_uniprotkb": "senju; CG14040", "gene_names_refseq": "CG14040; Dmel\\CG14040; senju", "protein_names_uniprotkb": "UDP-galactose transporter senju", "protein_names_refseq": "CG14040-PA; senju-PA; senju", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14040)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;25901322", "class_list": "", "function": "UDP-galactose transporter involved in the synthesis of galactose-containing glycans. Plays a role in quiescence of the innate immune response, possibly by regulating glycosylation of the Toll pathway ligand spz., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MYZ6", "ec_number_list": "", "go_molecular_function": "GO:0005459 UDP-galactose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0055085 transmembrane transport;GO:0045824 negative regulation of innate immune response;GO:0010560 positive regulation of glycoprotein biosynthetic process;GO:0045751 negative regulation of Toll signaling pathway;GO:0072334 UDP-galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VMU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMW9-1", "uniprot_id": "GMDS_DROME", "mass": 44784.0, "length": 395, "protein_name": "GDP-mannose 4,6-dehydratase", "gene_name": "Gmd", "organism": "Fruit fly", "refseq_name": "GDP-mannose 4,6-dehydratase", "refseq_ac": "NP_608888", "gene_names_uniprotkb": "Gmd; CG8890", "gene_names_refseq": "Brazil nut; CG8890; Dm-gmd; DmGMD; Dmel\\CG8890; GMD; Gmd; gmd; l(2)SH1606; l(2)SH2 1606", "protein_names_uniprotkb": "GDP-mannose 4,6-dehydratase; 4.2.1.47; Dm-gmd; GDP-D-mannose dehydratase; GDP-mannose dehydratase", "protein_names_refseq": "CG8890-PA; GDP-D-mannose 4,6-dehydratase; GDP-mannose 4,6 dehydratase; GDP-mannose 4,6-dehydrase; GDP-mannose 4,6-dehydratase; GDP-mannose dehydratase; Gmd-PA", "tax_id": 7227, "disease": "open-angle glaucoma (Disease Ontology:DOID:1067)", "pathway": " (dme:Dmel_CG8890); (R-DME-6787639)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;11698403;12537569;12537572;15692013;16650000;18194540", "class_list": "", "function": "Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose (also known as GDP-4-keto-6-deoxy-D-mannose or GDP-4-dehydro-alpha-D-rhamnose), an essential step in the synthesis of GDP-fucose from GDP-mannose (PubMed:16650000). Involved in Notch signaling during wing imaginal disc development; involved in providing GDP-fucose for Notch fucosylation (PubMed:15692013)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C7LA78;Q1H8X2;Q8T3U5", "ec_number_list": "4.2.1.47", "go_molecular_function": "GO:0008446 GDP-mannose 4,6-dehydratase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0045747 positive regulation of Notch signaling pathway;GO:0048477 oogenesis;GO:0045165 cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VMW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VMY1-1", "uniprot_id": "RM24_DROME", "mass": 29216.0, "length": 247, "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "mRpL24", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L24", "refseq_ac": "NP_523476", "gene_names_uniprotkb": "mRpL24; CG8849", "gene_names_refseq": "CG8849; Dmel\\CG8849; L24; RpL24; mRpL24", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24m; 39S ribosomal protein L24, mitochondrial; L24mt; MRP-L24", "protein_names_refseq": "CG8849-PA; mRpL24-PA; mitochondrial ribosomal protein L24", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8849); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VMY1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VN10-1", "uniprot_id": "Q9VN10_DROME", "mass": 32573.0, "length": 297, "protein_name": "Huckebein", "gene_name": "hkb", "organism": "Fruit fly", "refseq_name": "huckebein", "refseq_ac": "NP_524221", "gene_names_uniprotkb": "hkb; 5953; CG9768; Dmel\\CG9768; Dmel_CG9768; HKB; Hkb; anon-82B3; gurt", "gene_names_refseq": "5953; CG9768; Dmel\\CG9768; HKB; Hkb; anon-82B3; gurt; hkb", "protein_names_uniprotkb": "Huckebein", "protein_names_refseq": "CG9768-PA; gurtelchen; hkb-PA; huckbein; huckebein; hucklebein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9768)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001708 cell fate specification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0061024 membrane organization;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VN10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VN91-1", "uniprot_id": "MORN4_DROME", "mass": 22739.0, "length": 198, "protein_name": "MORN repeat-containing protein 4 homolog", "gene_name": "rtp", "organism": "Fruit fly", "refseq_name": "retinophilin", "refseq_ac": "NP_649520", "gene_names_uniprotkb": "rtp; CG10233; morn4; uta", "gene_names_refseq": "9C4; CG10233; Dmel\\CG10233; UTA; anon-83ABa; retin; rtp; uta", "protein_names_uniprotkb": "MORN repeat-containing protein 4 homolog; Retinophilin; undertaker", "protein_names_refseq": "CG10233-PA; Undertaker/Retinophilin; retinophilin; retitin; rtp-PA; undertaker", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10233)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;17285308;20107052;20739554;22496551;25822849", "class_list": "", "function": "Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma (PubMed:22496551). Organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors (PubMed:20107052). The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (PubMed:20739554)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042995 cell projection;GO:0016028 rhabdomere;GO:0033583 rhabdomere membrane", "go_biological_process": "GO:0007601 visual perception;GO:0048678 response to axon injury;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VN91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VN95-1", "uniprot_id": "ENOPH_DROME", "mass": 28297.0, "length": 256, "protein_name": "Enolase-phosphatase E1", "gene_name": "Enoph", "organism": "Fruit fly", "refseq_name": "Enolase-phosphatase", "refseq_ac": "NP_649523", "gene_names_uniprotkb": "Enoph; CG12173", "gene_names_refseq": "24644163; CG12173; Dmel\\CG12173; ENOPH; Enoph", "protein_names_uniprotkb": "Enolase-phosphatase E1; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; 3.1.3.77", "protein_names_refseq": "CG12173-PA; Enolase-phosphatase; Enoph-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12173); (R-DME-1237112)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3F1", "ec_number_list": "3.1.3.77", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0043874 acireductone synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VN95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VNA0-1", "uniprot_id": "TI17A_DROME", "mass": 18669.0, "length": 179, "protein_name": "Probable mitochondrial import inner membrane translocase subunit Tim17 1", "gene_name": "Tim17b1", "organism": "Fruit fly", "refseq_name": "Tim17b1", "refseq_ac": "NP_649526", "gene_names_uniprotkb": "Tim17b1; CG1158", "gene_names_refseq": "BcDNA:AT16284; CG1158; Dmel\\CG1158; Tim17b1", "protein_names_uniprotkb": "Probable mitochondrial import inner membrane translocase subunit Tim17 1", "protein_names_refseq": "CG1158-PA; Tim17b1-PA; Tim17b1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1158); (R-DME-1268020)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A730;Q8MZB4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VNA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VND8-1", "uniprot_id": "RHEB_DROME", "mass": 20731.0, "length": 182, "protein_name": "GTP-binding protein Rheb homolog", "gene_name": "Rheb", "organism": "Fruit fly", "refseq_name": "Ras homolog enriched in brain, isoform A", "refseq_ac": "NP_730950", "gene_names_uniprotkb": "Rheb; CG1081", "gene_names_refseq": "CG1081; DReb; Dm Rheb; DmRheb; Dmel\\CG1081; Q9VND8; RHEB; RheB; Rheb; dRheb; rheb", "protein_names_uniprotkb": "GTP-binding protein Rheb homolog; 3.6.5.-", "protein_names_refseq": "CG1081-PA; RAS homolog enriched in brain; Ras homolog enriched in brain ortholog; Ras homolog enriched in brain, isoform A; Ras homologue enriched in brain; Ras homology enriched in brain; Rheb-PA", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); tuberous sclerosis (Disease Ontology:DOID:13515); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG1081); (R-DME-110523); (R-DME-1632852); (R-DME-165159); (R-DME-166208); (R-DME-380972); (R-DME-5628897); (R-DME-8943724); (R-DME-9639288)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "10731132;11389445;11752451;12172554;12537569;12537572;12771962;22493059", "class_list": "", "function": "Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis (PubMed:22493059). Stimulates the phosphorylation of S6K through activation of TORC1 signaling (PubMed:22493059). May also have a role in activating TORC2 signaling (PubMed:22493059)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KIB7", "ec_number_list": "3.6.5.5;3.6.5.2;3.6.5.-;2.7.11.1;5.2.1.8;3.6.5.3;7.1.2.2", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0033500 carbohydrate homeostasis;GO:0030307 positive regulation of cell growth;GO:0042594 response to starvation;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VND8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VNE7-1", "uniprot_id": "C42ES_DROME", "mass": 9586.0, "length": 85, "protein_name": "CDC42 small effector protein homolog", "gene_name": "Spec2", "organism": "Fruit fly", "refseq_name": "Spec2", "refseq_ac": "NP_730968", "gene_names_uniprotkb": "Spec2; CG14672", "gene_names_refseq": "BcDNA:LD24607; CG14672; Dmel\\CG14672; SPEC2; SPEC; Spec2; Spec; dSPEC2; dSPEC", "protein_names_uniprotkb": "CDC42 small effector protein homolog; Dspec", "protein_names_refseq": "CG14672-PA; Spec2-PA; Spec2; small protein effector of Cdc42 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14672)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95T20", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0035023 regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VNE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VNG0-1", "uniprot_id": "MED27_DROME", "mass": 33868.0, "length": 293, "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "MED27", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 27", "refseq_ac": "NP_649569", "gene_names_uniprotkb": "MED27; CG1245; Trap37", "gene_names_refseq": "CG1245; CRSP34; Dmel\\CG1245; MED27; Med27; Trap37; dCRSP34; dCrsp34; dTRAP37; med27", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 27; Mediator complex subunit 27; dCRSP34; dMED27; dTRAP37", "protein_names_refseq": "CG1245-PA; MED27-PA; mediator complex subunit 27", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1245); (R-DME-9841922)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;11259581;12021283;12537572;16751183", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VNG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VNG1-1", "uniprot_id": "GGNB2_DROME", "mass": 77061.0, "length": 671, "protein_name": "Gametogenetin-binding protein 2-like", "gene_name": "CG2182", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_649570", "gene_names_uniprotkb": "CG2182", "gene_names_refseq": "CG2182; Dmel\\CG2182", "protein_names_uniprotkb": "Gametogenetin-binding protein 2-like", "protein_names_refseq": "CG2182-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2182)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IPP6;Q8MR07", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VNG1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VNP5-1", "uniprot_id": "BOYB_DROME", "mass": 121400.0, "length": 1059, "protein_name": "Putative ATP-dependent RNA helicase BoYb", "gene_name": "BoYb", "organism": "Fruit fly", "refseq_name": "brother of Yb", "refseq_ac": "NP_649430", "gene_names_uniprotkb": "BoYb; CG11133", "gene_names_refseq": "BoYb; CG11133; Dmel\\CG11133; boYb", "protein_names_uniprotkb": "Putative ATP-dependent RNA helicase BoYb; 3.6.4.13; Brother of Yb", "protein_names_refseq": "BoYb-PA; CG11133-PA; brother of Yb", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11133)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21863019", "class_list": "", "function": "Involved in primary piRNA biogenesis in germline cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7YTZ8", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003676 nucleic acid binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0070725 Yb body", "go_biological_process": "GO:0051321 meiotic cell cycle;GO:0042078 germ-line stem cell division;GO:0140990 primary piRNA processing;GO:0140965 secondary piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VNP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VNT5-1", "uniprot_id": "TRXR2_DROME", "mass": 56277.0, "length": 516, "protein_name": "Thioredoxin reductase 2, mitochondrial", "gene_name": "Trxr2", "organism": "Fruit fly", "refseq_name": "thioredoxin reductase 2", "refseq_ac": "NP_524216", "gene_names_uniprotkb": "Trxr2; CG11401; Trxr-2", "gene_names_refseq": "CG11401; Dm-TrxR; DmTrxR-2; DmTrxR; DmTrx; Dmel\\CG11401; TRR; TrxR; Trxr-2; Trxr2; trxr-2", "protein_names_uniprotkb": "Thioredoxin reductase 2, mitochondrial; 1.8.1.9", "protein_names_refseq": "CG11401-PA; Trxr2-PA; thioredoxin reductase 2; thioredoxin reductase; thioredoxin-reductase-2", "tax_id": 7227, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); familial glucocorticoid deficiency (Disease Ontology:DOID:0080620); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG11401); (R-DME-3299685); (R-DME-499943); (R-DME-5263617); (R-DME-5628897)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.1.9", "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VNT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VP04-1", "uniprot_id": "ORMDL_DROME", "mass": 17570.0, "length": 154, "protein_name": "ORM1-like protein", "gene_name": "ORMDL", "organism": "Fruit fly", "refseq_name": "orosomucoid 1-like", "refseq_ac": "NP_730669", "gene_names_uniprotkb": "ORMDL; CG14577", "gene_names_refseq": "CG14577; Dmel\\CG14577; ORMDL; dORMDL", "protein_names_uniprotkb": "ORM1-like protein; dORMDL", "protein_names_refseq": "CG14577-PA; ORMDL-PA; orosomucoid 1-like", "tax_id": 7227, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); asthma (Disease Ontology:DOID:2841); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (dme:Dmel_CG14577); (R-DME-1660661); (R-DME-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12093374;12537572", "class_list": "", "function": "Negative regulator of sphingolipid synthesis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ27;Q8MX27", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:2000303 regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0090156 intracellular sphingolipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VP04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VP47-1", "uniprot_id": "TSR1_DROME", "mass": 93717.0, "length": 814, "protein_name": "Pre-rRNA-processing protein TSR1 homolog", "gene_name": "Tsr1", "organism": "Fruit fly", "refseq_name": "Tsr1 ribosome assembly factor", "refseq_ac": "NP_649304", "gene_names_uniprotkb": "Tsr1; CG7338", "gene_names_refseq": "CG7338; Dmel\\CG7338; Tsr1; tsr1", "protein_names_uniprotkb": "Pre-rRNA-processing protein TSR1 homolog; Tsr1 ribosome assembly factor", "protein_names_refseq": "CG7338-PA; Tsr1 ribosome assembly factor; Tsr1-PA; ribosome assembly factor Tsr1", "tax_id": 7227, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040)", "pathway": " (dme:Dmel_CG7338)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Required during maturation of the 40S ribosomal subunit in the nucleolus., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B5RIG8;Q86PD4;Q95TR7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VP47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VPD2-1", "uniprot_id": "NUBP2_DROME", "mass": 28250.0, "length": 260, "protein_name": "Cytosolic Fe-S cluster assembly factor Nubp2 homolog", "gene_name": "Nubp2", "organism": "Fruit fly", "refseq_name": "NUBP iron-sulfur cluster assembly factor 2", "refseq_ac": "NP_649243", "gene_names_uniprotkb": "Nubp2; CG4858", "gene_names_refseq": "CG4858; Cfd1; Dmel\\CG4858; Nubp2", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor Nubp2 homolog", "protein_names_refseq": "CG4858-PA; NUBP iron-sulfur cluster assembly factor 2; Nubp2-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4858)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The Nubp1-Nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding;GO:0140663 ATP-dependent FeS chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1904564 cytosolic [4Fe-4S] assembly scaffold complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VPD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VPD3-1", "uniprot_id": "PTSS_DROME", "mass": 56835.0, "length": 498, "protein_name": "Phosphatidylserine synthase", "gene_name": "Pss", "organism": "Fruit fly", "refseq_name": "phosphatidylserine synthase, isoform B", "refseq_ac": "NP_001262118", "gene_names_uniprotkb": "Pss; CG4825; l(3)77CDf; ptdss1", "gene_names_refseq": "CG4825; Dmel\\CG4825; Pss; l(3)04521; l(3)77CDf; pss; ptdss1", "protein_names_uniprotkb": "Phosphatidylserine synthase; 2.7.8.29", "protein_names_refseq": "CDP-diacylglycerol-serine O-phosphatidyltransferase; CG4825-PB; Pss-PB; lethal (3) 77CDf; phosphatidylserine synthase, isoform B", "tax_id": 7227, "disease": "Lenz-Majewski hyperostotic dwarfism (Disease Ontology:DOID:0111507)", "pathway": " (dme:Dmel_CG4825); (R-DME-1483101)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;31869331", "class_list": "", "function": "Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "M9PIC3", "ec_number_list": "2.7.8.29", "go_molecular_function": "GO:0016780 phosphotransferase activity, for other substituted phosphate groups;GO:0106258 L-serine-phosphatidylcholine phosphatidyltransferase activity;GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VPD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VPF0-1", "uniprot_id": "ATK_DROME", "mass": 172130.0, "length": 1535, "protein_name": "Protein artichoke", "gene_name": "atk", "organism": "Fruit fly", "refseq_name": "artichoke, isoform B", "refseq_ac": "NP_001262113", "gene_names_uniprotkb": "atk; CG5195", "gene_names_refseq": "CG5195; CT16609; Dmel\\CG5195; atk; tartan/capricious-like", "protein_names_uniprotkb": "Protein artichoke", "protein_names_refseq": "CG5195-PB; artichoke, isoform B; artichoke; atk-PB", "tax_id": 7227, "disease": "isolated growth hormone deficiency (Disease Ontology:DOID:0060870); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); nephrotic syndrome (Disease Ontology:DOID:1184); Noonan syndrome (Disease Ontology:DOID:3490); anorexia nervosa (Disease Ontology:DOID:8689)", "pathway": " (dme:Dmel_CG5195)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;24496014;40245499", "class_list": "", "function": "Required for normal morphology and function of ciliated sensory organs., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E3CTU4;F0JAL6;Q6NR19", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0060271 cilium assembly;GO:0040011 locomotion;GO:0007423 sensory organ development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VPF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VPH2-1", "uniprot_id": "PRI2_DROME", "mass": 61436.0, "length": 533, "protein_name": "DNA primase large subunit", "gene_name": "Prim2", "organism": "Fruit fly", "refseq_name": "DNA primase subunit 2", "refseq_ac": "NP_652001", "gene_names_uniprotkb": "Prim2; CG5553; DNApol-alpha60; DNAprim; S(faf)240", "gene_names_refseq": "BcDNA:GM13640; CG5553; DNA polalpha; DNApol-alpha60; DNAprimase; DNAprim; Dmel\\CG5553; Dmpol alpha; GM13640; PRI2; Polalpha 60 kDa; Pol; Prim2; S(faf)240; l(3)77ABe; l(3)j10B2; pol alpha; polalpha", "protein_names_uniprotkb": "DNA primase large subunit; DNA polymerase subunit beta; Suppressor of fat facets 240", "protein_names_refseq": "CG5553-PA; DNA polymerase alpha 58,000 beta subunit; DNA polymerase alpha 60,000 beta subunit; DNA polymerase alpha 60kD subunit; DNA primase subunit 2; DNA primase; DNA replication primer; DNApol-alpha60; DNAprim; Prim2-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5553); (R-DME-113501); (R-DME-68952); (R-DME-68962); (R-DME-69091); (R-DME-69166); (R-DME-69183)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10366721;10731132;10731138;11102374;12537572;6403945;6409898;6773966;6812052", "class_list": "", "function": "Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:6403945, PubMed:6409898, PubMed:6773966). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit PolA1, an accessory subunit PolA2 and two primase subunits, the catalytic subunit Prim1 and the regulatory subunit Prim2) is recruited to DNA at the replicative forks (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:6812052). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:6812052). Stabilizes and modulates the activity of the catalytic subunit (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U9Q5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0006269 DNA replication, synthesis of primer;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VPH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VPP5-1", "uniprot_id": "RNH2A_DROME", "mass": 38750.0, "length": 347, "protein_name": "Ribonuclease H2 subunit A", "gene_name": "CG13690", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_608521", "gene_names_uniprotkb": "CG13690", "gene_names_refseq": "CG13690; Dmel\\CG13690", "protein_names_uniprotkb": "Ribonuclease H2 subunit A; 3.1.26.4; RNase H2 subunit A; RNase HI large subunit; Ribonuclease HI large subunit; Ribonuclease HI subunit A", "protein_names_refseq": "CG13690-PA; uncharacterized protein", "tax_id": 7227, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (dme:Dmel_CG13690)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3V1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0043137 DNA replication, removal of RNA primer", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VPP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VPR4-1", "uniprot_id": "NLE_DROME", "mass": 53810.0, "length": 488, "protein_name": "Protein Notchless", "gene_name": "Nle", "organism": "Fruit fly", "refseq_name": "notchless", "refseq_ac": "NP_477294", "gene_names_uniprotkb": "Nle; CG2863", "gene_names_refseq": "CG2863; Dmel\\CG2863; Nle; anon-WO0026364; l(2)k13714; nle", "protein_names_uniprotkb": "Protein Notchless", "protein_names_refseq": "CG2863-PA; Nle-PA; notchless", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2863); (R-DME-983168); (R-DME-9958825)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9857191", "class_list": "", "function": "Plays a role in regulating Notch activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O96995;Q8T4A2", "ec_number_list": "", "go_molecular_function": "GO:0005112 Notch binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0045747 positive regulation of Notch signaling pathway;GO:0045746 negative regulation of Notch signaling pathway;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VPR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VPX6-1", "uniprot_id": "Q9VPX6_DROME", "mass": 84486.0, "length": 783, "protein_name": "Adenylyl cyclase-associated protein", "gene_name": "capt", "organism": "Fruit fly", "refseq_name": "capulet, isoform B", "refseq_ac": "NP_001033870", "gene_names_uniprotkb": "capt; Acap; BcDNA:LD24380; CAP; CG33979; CG5061; CG5074; CP; Capt; Capulet; Cap; Dcap; Dmel\\CG33979; Dmel_CG33979; acu; capping protein; cap; cyclase-associated protein; l(2)06955; punc", "gene_names_refseq": "Acap; BcDNA:LD24380; CAP; CG33979; CG5061; CG5074; CP; Capt; Capulet; Cap; Dcap; Dmel\\CG33979; acu; capping protein; capt; cap; cyclase-associated protein; l(2)06955; punc", "protein_names_uniprotkb": "Adenylyl cyclase-associated protein", "protein_names_refseq": "Act up; CG33979-PB; Cyclase-associated protein; adenylyl cyclase-associated protein; capt-PB; capulet, isoform B; capulet; cyclase associated protein capulet; punctate", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dme:Dmel_CG33979); (R-DME-6798695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15952742;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BII8", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008179 adenylate cyclase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005829 cytosol", "go_biological_process": "GO:0048749 compound eye development;GO:0007015 actin filament organization;GO:0046716 muscle cell cellular homeostasis;GO:0000902 cell morphogenesis;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VPX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VQ79-2", "uniprot_id": "AIFM1_DROME", "mass": 81217.0, "length": 739, "protein_name": "Putative apoptosis-inducing factor 1, mitochondrial", "gene_name": "AIF", "organism": "Fruit fly", "refseq_name": "apoptosis inducing factor, isoform A", "refseq_ac": "NP_608649", "gene_names_uniprotkb": "AIF; CG7263", "gene_names_refseq": "AIF; CG7263; DmAIF; Dmel\\CG7263; SD03428p; aif; dAIF", "protein_names_uniprotkb": "Putative apoptosis-inducing factor 1, mitochondrial; 1.6.99.-; DmAIF", "protein_names_refseq": "AIF-PA; CG7263-PA; apoptosis inducing factor, isoform A; apoptosis inducing factor", "tax_id": 7227, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); Charcot-Marie-Tooth disease X-linked recessive 4 (Disease Ontology:DOID:0110212); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); combined oxidative phosphorylation deficiency 6 (Disease Ontology:DOID:0111502); X-linked deafness 5 (Disease Ontology:DOID:0111741); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); retinal detachment (Disease Ontology:DOID:5327)", "pathway": " (dme:Dmel_CG7263)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18309327", "class_list": "", "function": "Probable NADH oxidoreductase (By similarity). Mitochondrial effector of cell death that plays roles in developmentally regulated cell death and normal mitochondrial function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RIR8;Q95TL9;Q960F8", "ec_number_list": "1.6.99.1;1.6.99.-", "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0006915 apoptotic process;GO:0010623 programmed cell death involved in cell development;GO:0160203 mitochondrial disulfide relay system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VQ79-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VQ93-1", "uniprot_id": "GOLP3_DROME", "mass": 33511.0, "length": 294, "protein_name": "Golgi phosphoprotein 3 homolog sauron", "gene_name": "sau", "organism": "Fruit fly", "refseq_name": "sauron, isoform D", "refseq_ac": "NP_001014460", "gene_names_uniprotkb": "sau; CG7085; GOLPH3; l(2)s5379; rti", "gene_names_refseq": "BEST:LD28579; BcDNA:LD10657; CG7085; Dmel\\CG7085; GOLPH3; Rotini; Rti; Sauron; Vps74; dGOLPH3; l(2)s5379; rti; sau", "protein_names_uniprotkb": "Golgi phosphoprotein 3 homolog sauron; Protein rotini", "protein_names_refseq": "CG7085-PD; lethal (2) s5379; rotini; sau-PD; sauron, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7085)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;19837035;23720043;24786584", "class_list": "", "function": "Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi (PubMed:19837035, PubMed:24786584). Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (By similarity). May also bind to the coatomer to regulate Golgi membrane trafficking (PubMed:23720043, PubMed:24786584). May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion (By similarity). Also involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part (By similarity). Functions in cytokinesis by regulating contractile ring formation and vesicle trafficking during cleavage furrow ingression (PubMed:24786584). May also have a role in the intital steps of central spindle formation (PubMed:24786584). Can also bind phosphatidylinositol-3-phosphate and phosphatidylinositol-5-phosphate in vitro (PubMed:24786584)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0031267 small GTPase binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0032154 cleavage furrow", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0046718 symbiont entry into host cell;GO:0000281 mitotic cytokinesis;GO:0043001 Golgi to plasma membrane protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VQ93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VQE9-1", "uniprot_id": "TMTC1_DROME", "mass": 94857.0, "length": 859, "protein_name": "Protein O-mannosyl-transferase Tmtc1", "gene_name": "Tmtc1", "organism": "Fruit fly", "refseq_name": "transmembrane O-mannosyltransferase targeting cadherins 1", "refseq_ac": "NP_995615", "gene_names_uniprotkb": "Tmtc1; CG31690", "gene_names_refseq": "CG11542; CG15397; CG31690; Dmel\\CG31690; TMTC1; Tmtc1", "protein_names_uniprotkb": "Protein O-mannosyl-transferase Tmtc1; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 1; Transmembrane and tetratricopeptide repeat-containing 1", "protein_names_refseq": "CG31690-PE; Tmtc1-PE; transmembrane O-mannosyltransferase targeting cadherins 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31690)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3PFE4;Q7KU17;Q8T3V2", "ec_number_list": "2.4.1.109", "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VQE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VQS6-1", "uniprot_id": "DRM_DROME", "mass": 10120.0, "length": 81, "protein_name": "Protein drumstick", "gene_name": "drm", "organism": "Fruit fly", "refseq_name": "drumstick, isoform B", "refseq_ac": "NP_536788", "gene_names_uniprotkb": "drm; CG10016; Dmel\\CG10016; Dmel_CG10016; drum", "gene_names_refseq": "CG10016; Dmel\\CG10016; drm; drum", "protein_names_uniprotkb": "Protein drumstick", "protein_names_refseq": "CG10016-PB; drm-PB; drumstick, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10016)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11784087;12117814;12537568;12537569;12537572;12537573;12537574;14568103;14597202;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Putative transcription factor. May function redundantly with odd and sob in leg joint formation during the larval stages, acting downstream of Notch activation. Acts in a hierarchy during foregut and hindgut patterning and morphogenesis, antagonizing lin to relieve the repressive effect on bowl. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V041;Q49UC1;Q8SZH7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048619 embryonic hindgut morphogenesis;GO:0007442 hindgut morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VQS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR19-1", "uniprot_id": "ELBA3_DROME", "mass": 43008.0, "length": 379, "protein_name": "Early boundary activity protein 3", "gene_name": "Elba3", "organism": "Fruit fly", "refseq_name": "early boundary activity 3", "refseq_ac": "NP_608850", "gene_names_uniprotkb": "Elba3; CG15634", "gene_names_refseq": "CG15634; Dmel\\CG15634; Elba3; Elba", "protein_names_uniprotkb": "Early boundary activity protein 3", "protein_names_refseq": "CG15634-PA; Elba3-PA; early boundary activity 3; early boundary factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15634)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;23240086;25561495", "class_list": "", "function": "The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba3 lacks DNA-binding activity and plays the role of an adapter protein, bringing Elba1 and 2 together, thereby establishing a complex that recognizes the asymmetric sequence motif through the BEN domains of Elba1 and 2 (PubMed:23240086)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005677 chromatin silencing complex", "go_biological_process": "GO:0033696 heterochromatin boundary formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VR19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR25-1", "uniprot_id": "Q9VR25_DROME", "mass": 50712.0, "length": 450, "protein_name": "Factor of interpulse interval", "gene_name": "fipi", "organism": "Fruit fly", "refseq_name": "factor of interpulse interval", "refseq_ac": "NP_787975", "gene_names_uniprotkb": "fipi; 15630; CG15630; CG31970; CT35785; Dmel\\CG15630; Dmel_CG15630; Fipi", "gene_names_refseq": "15630; CG15630; CG31970; CT35785; Dmel\\CG15630; Fipi; fipi", "protein_names_uniprotkb": "Factor of interpulse interval", "protein_names_refseq": "CG15630-PA; factor of interpulse interval; fipi-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15630); (R-DME-1474228); (R-DME-1971475); (R-DME-2022928); (R-DME-2024096); (R-DME-216083); (R-DME-3000171); (R-DME-3000178); (R-DME-375165); (R-DME-419037); (R-DME-445144); (R-DME-5673001); (R-DME-9769739); (R-DME-9913351)", "pathway_count": 14, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0030154 cell differentiation;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0009653 anatomical structure morphogenesis;GO:0007444 imaginal disc development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VR25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR56-1", "uniprot_id": "TM10A_DROME", "mass": 36442.0, "length": 319, "protein_name": "tRNA (guanine(9)-N(1))-methyltransferase Trmt10A", "gene_name": "Trmt10A", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_608464", "gene_names_uniprotkb": "Trmt10A; CG14618", "gene_names_refseq": "CG14618; Dmel\\CG14618", "protein_names_uniprotkb": "tRNA (guanine(9)-N(1))-methyltransferase Trmt10A; 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 2 homolog; dTrmt10A; tRNA methyltransferase 10A", "protein_names_refseq": "CG14618-PA; uncharacterized protein", "tax_id": 7227, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (dme:Dmel_CG14618)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;38155219", "class_list": "", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:38155219). Modulates Mettl3-mediated N6-methyladenosine (m6A) methylation of mRNA 5'-UTRs and 3'-UTRs independent of its methyltransferase activity; influences mRNA stability and protein levels, in particular of Hsp70 chaperone proteins and other stress response proteins (PubMed:38155219). Also regulates stability of transcripts encoding proteins involved in signaling processes and proteins involved in neurogenesis and axon guidance pathways (PubMed:38155219)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.221", "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0034605 cellular response to heat;GO:0002939 tRNA N1-guanine methylation;GO:1905870 positive regulation of 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VR56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR59-1", "uniprot_id": "VIP1_DROME", "mass": 188677.0, "length": 1696, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase", "gene_name": "l(1)G0196", "organism": "Fruit fly", "refseq_name": "lethal (1) G0196, isoform K", "refseq_ac": "NP_001097041", "gene_names_uniprotkb": "l(1)G0196; CG14616; CG32502; Dmel\\CG14616; Dmel_CG14616", "gene_names_refseq": "CG14616; CG32502; Dmel\\CG14616; l(1)G0196", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; 2.7.4.24; InsP6 and PP-IP5 kinase", "protein_names_refseq": "CG14616-PK; l(1)G0196-PK; lethal (1) G0196, isoform K", "tax_id": 7227, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); autosomal recessive nonsyndromic deafness 100 (Disease Ontology:DOID:0111638); keratoconus (Disease Ontology:DOID:10126)", "pathway": " (dme:Dmel_CG14616); (R-DME-1855167)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17018572;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VEZ0;A8JUU5;Q6AWF3;Q8IQ22;Q8IQ23;Q8IQ24", "ec_number_list": "2.7.4.24", "go_molecular_function": "GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0052723 inositol hexakisphosphate 1-kinase activity;GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VR59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR89-1", "uniprot_id": "PNO1_DROME", "mass": 26677.0, "length": 240, "protein_name": "RNA-binding protein pno1", "gene_name": "l(1)G0004", "organism": "Fruit fly", "refseq_name": "lethal (1) G0004", "refseq_ac": "NP_608387", "gene_names_uniprotkb": "l(1)G0004; CG11738", "gene_names_refseq": "CG11738; Dmel\\CG11738; l(1)G0004; l(G0004)", "protein_names_uniprotkb": "RNA-binding protein pno1", "protein_names_refseq": "CG11738-PA; l(1)G0004-PA; lethal (1) G0004", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11738)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VR89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR93-1", "uniprot_id": "ATPMK_DROME", "mass": 7303.0, "length": 63, "protein_name": "ATP synthase membrane subunit K, mitochondrial", "gene_name": "CG15458", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_652293", "gene_names_uniprotkb": "CG15458", "gene_names_refseq": "CG15458; Dmel\\CG15458", "protein_names_uniprotkb": "ATP synthase membrane subunit K, mitochondrial", "protein_names_refseq": "CG15458-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15458)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7FNN0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VR93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR94-1", "uniprot_id": "OB19A_DROME", "mass": 16323.0, "length": 146, "protein_name": "General odorant-binding protein 19a", "gene_name": "Obp19a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 19a", "refseq_ac": "NP_728338", "gene_names_uniprotkb": "Obp19a; CG11748", "gene_names_refseq": "19a; CG11748; DmelObp19a; Dmel\\CG11748; OBP19a; Obp19a", "protein_names_uniprotkb": "General odorant-binding protein 19a", "protein_names_refseq": "CG11748-PC; Obp19a-PC; Odorant-binding protein 19a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11748)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11729153;12537572", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9QNY2;G2J5W2;Q8IQ33", "ec_number_list": "", "go_molecular_function": "GO:0005549 odorant binding;GO:0035275 dibutyl phthalate binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VR94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VR99-1", "uniprot_id": "CATIN_DROME", "mass": 86556.0, "length": 720, "protein_name": "Splicing factor Cactin", "gene_name": "cactin", "organism": "Fruit fly", "refseq_name": "cactin", "refseq_ac": "NP_523422", "gene_names_uniprotkb": "cactin; CG1676", "gene_names_refseq": "CG1676; Cactin; Dmel\\CG1676; cactin", "protein_names_uniprotkb": "Splicing factor Cactin; Cactus-interacting protein", "protein_names_refseq": "CG1676-PB; cactin-PB; cactin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1676); (R-DME-72163)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;10842059;12537572;18327897", "class_list": "", "function": "Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Plays a role during early embryonic development (PubMed:10842059). Involved in the dorsal-ventral embryonic patterning (PubMed:10842059). Probably acts as a negative regulator of the NF-kappa-B (Rel) signaling pathway (PubMed:10842059)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NBV5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0002760 positive regulation of antimicrobial humoral response;GO:0098586 cellular response to virus;GO:0000398 mRNA splicing, via spliceosome;GO:0009950 dorsal/ventral axis specification;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VR99-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VRA2-1", "uniprot_id": "MOCOS_DROME", "mass": 88104.0, "length": 781, "protein_name": "Molybdenum cofactor sulfurase", "gene_name": "mal", "organism": "Fruit fly", "refseq_name": "maroon-like, isoform B", "refseq_ac": "NP_001285493", "gene_names_uniprotkb": "mal; 5; CG1692; Dmel\\CG1692; Dmel_CG1692; SRF; bz; ma-l", "gene_names_refseq": "5; CG1692; Dmel\\CG1692; SRF; bz; ma-l; mal", "protein_names_uniprotkb": "Molybdenum cofactor sulfurase; 2.8.1.9; MCS; MOS; Ma-l; MoCo sulfurase; Molybdenum cofactor sulfurtransferase; Protein maroon-like", "protein_names_refseq": "CG1692-PB; bronzy; mal-PB; maroon-like, isoform B; maroonlike; section 5", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); obstructive nephropathy (Disease Ontology:DOID:0070314); xanthinuria type II (Disease Ontology:DOID:0070453)", "pathway": " (dme:Dmel_CG1692); (R-DME-947581)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;11029694;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;6801056", "class_list": "", "function": "Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form., [UniProtKB, HAMAP, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U9P1", "ec_number_list": "2.8.1.9", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0030170 pyridoxal phosphate binding;GO:0016829 lyase activity;GO:0008265 molybdenum cofactor sulfurtransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0043545 molybdopterin cofactor metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VRA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VRJ1-1", "uniprot_id": "SYAM_DROME", "mass": 113104.0, "length": 1012, "protein_name": "Alanine--tRNA ligase, mitochondrial", "gene_name": "AlaRS-m", "organism": "Fruit fly", "refseq_name": "Alanyl-tRNA synthetase, mitochondrial", "refseq_ac": "NP_523932", "gene_names_uniprotkb": "AlaRS-m; Aats-ala-m; CG4633; alaS", "gene_names_refseq": "Aats-ala-m; AlaRS-m; AlaS; CG4633; Dm mt AlaRS; Dmel\\CG4633", "protein_names_uniprotkb": "Alanine--tRNA ligase, mitochondrial; 6.1.1.7; AlaRS; Alanyl-tRNA synthetase", "protein_names_refseq": "AlaRS-m-PA; Alanyl-tRNA synthetase, mitochondrial; CG4633-PA; mitochondrial alanyl-tRNA synthetase", "tax_id": 7227, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); progressive leukoencephalopathy with ovarian failure (Disease Ontology:DOID:0070396); combined oxidative phosphorylation deficiency 8 (Disease Ontology:DOID:0111479); dermatomyositis (Disease Ontology:DOID:10223); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); microcephaly (Disease Ontology:DOID:10907); axonal neuropathy (Disease Ontology:DOID:7319)", "pathway": " (dme:Dmel_CG4633)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;11035802;11532948;12537569;12537572;15053877", "class_list": "", "function": "Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U6B6", "ec_number_list": "6.1.1.7", "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004813 alanine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006419 alanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VRJ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VRJ2-1", "uniprot_id": "FITM2_DROME", "mass": 47884.0, "length": 423, "protein_name": "Acyl-coenzyme A diphosphatase FITM2", "gene_name": "Fitm2", "organism": "Fruit fly", "refseq_name": "Fat storage inducing transmembrane protein, isoform A", "refseq_ac": "NP_647944", "gene_names_uniprotkb": "Fitm2; CG10671; Fit2; Fitm", "gene_names_refseq": "CG10671; Dmel\\CG10671; FIT2; Fitm; i136", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase FITM2; 3.6.1.-; Fat storage-inducing transmembrane protein 2; Fat storage-inducing transmembrane protein; Fat-inducing protein 2", "protein_names_refseq": "CG10671-PA; Fat storage inducing transmembrane protein, isoform A; Fitm-PA", "tax_id": 7227, "disease": "Siddiqi syndrome (Disease Ontology:DOID:0081273); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (dme:Dmel_CG10671); (R-DME-8964572)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;28067622", "class_list": "", "function": "Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PubMed:28067622). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity) (PubMed:28067622). Required for correct morphology of nociceptive multi-dendritic sensory neurons (PubMed:28067622). Required for normal mechanical amplification in hearing (PubMed:28067622)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8I933;Q95TQ4", "ec_number_list": "3.6.1.-", "go_molecular_function": "GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0055088 lipid homeostasis;GO:0007605 sensory perception of sound;GO:0019915 lipid storage;GO:0034389 lipid droplet organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VRJ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VRV7-1", "uniprot_id": "SF3B6_DROME", "mass": 14194.0, "length": 121, "protein_name": "Splicing factor 3B subunit 6", "gene_name": "Sf3b6", "organism": "Fruit fly", "refseq_name": "splicing factor 3b subunit 6", "refseq_ac": "NP_648037", "gene_names_uniprotkb": "Sf3b6; CG13298", "gene_names_refseq": "CG13298; Dmel\\CG13298; SF3B6; Sf3b6; cg13298", "protein_names_uniprotkb": "Splicing factor 3B subunit 6; Pre-mRNA branch site p14-like protein", "protein_names_refseq": "CG13298-PA; Sf3b6-PA; splicing factor 3b subunit 6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13298)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18981222", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (Probable). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing (By similarity). Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VRV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VS36-1", "uniprot_id": "TO6BL_DROME", "mass": 37365.0, "length": 331, "protein_name": "Meiotic recombination protein P22", "gene_name": "mei-P22", "organism": "Fruit fly", "refseq_name": "meiotic P22", "refseq_ac": "NP_523956", "gene_names_uniprotkb": "mei-P22; CG14827", "gene_names_refseq": "CG14827; Dmel\\CG14827; MEI-P22; Mei-P22; mei-P22", "protein_names_uniprotkb": "Meiotic recombination protein P22", "protein_names_refseq": "CG14827-PA; mei-P22-PA; meiotic P22", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14827)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12242237;12537572;26917764", "class_list": "", "function": "Required for formation of the mei-W68-mediated double-strand breaks (DSBs) that initiate meiotic recombination., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9QPF9;Q9U626", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000785 chromatin", "go_biological_process": "GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VS36-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VS60-1", "uniprot_id": "SMSR1_DROME", "mass": 67063.0, "length": 600, "protein_name": "Ceramide phosphoethanolamine synthase", "gene_name": "SMSr", "organism": "Fruit fly", "refseq_name": "sphingomyelin synthase related", "refseq_ac": "NP_648114", "gene_names_uniprotkb": "SMSr; CG32380", "gene_names_refseq": "CG32380; CG8572; CG8576; Css3beta; Dmel\\CG32380; SMSr; dSMSr; dmSMSr", "protein_names_uniprotkb": "Ceramide phosphoethanolamine synthase; 2.7.8.-; CPE synthase; SMSr; Sphingomyelin synthase-related 1", "protein_names_refseq": "CG32380-PA; CPE synthase; SMSr-PA; sphingomyelin synthase related", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32380); (R-DME-1660661)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;14685263;18327897;19506037", "class_list": "", "function": "A phosphatidylethanolamine (PE)/ceramide ethanolamine phosphotransferase that catalyzes the synthesis of ceramide phosphoethanolamines (CPE), a class of lipids that is a sphingomyelin analog and a major membrane constituent in Drosophila. Transfers the head group from PE (1,2-diacyl-sn-glycero-3-phosphoethanolamine) on to different ceramides such as N-acylsphinganine (dihydroceramide) and N-acyl-(4R)-hydroxysphinganine (phytoceramide) to form N-acyl-sphinganine-1-phosphoethanolamine and N-acyl-(4R)-hydroxysphinganine-1-phosphoethanolamine, respectively. Operates as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum, which is critical for the integrity of the early secretory pathway., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q961G5;Q9VS61", "ec_number_list": "2.7.8.-", "go_molecular_function": "GO:0033188 sphingomyelin synthase activity;GO:0047493 ceramide cholinephosphotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:2000303 regulation of ceramide biosynthetic process;GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VS60-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VS78-1", "uniprot_id": "CP316_DROME", "mass": 56278.0, "length": 484, "protein_name": "Probable cytochrome P450 316a1", "gene_name": "Cyp316a1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 316a1", "refseq_ac": "NP_648129", "gene_names_uniprotkb": "Cyp316a1; CG8540", "gene_names_refseq": "316a1; CG8540; CYP316a1; Cyp316a1; Dmel\\CG8540; cyp316a1", "protein_names_uniprotkb": "Probable cytochrome P450 316a1; 1.14.-.-; CYPCCCXVIA1", "protein_names_refseq": "CG8540-PB; Cyp316a1-PB; cytochrome P450 316a1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8540); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10731132;12537572;40245499", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VS78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VS79-1", "uniprot_id": "CP4D8_DROME", "mass": 57819.0, "length": 505, "protein_name": "Cytochrome P450 4d8", "gene_name": "Cyp4d8", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "Cyp4d8; CG4321", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 4d8; 1.14.-.-; CYPIVD8", "protein_names_refseq": "", "tax_id": 7227, "disease": "Bietti crystalline corneoretinal dystrophy (Disease Ontology:DOID:0050664); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dme:Dmel_CG4321); (R-DME-193144); (R-DME-196791); (R-DME-211916); (R-DME-211976)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8676871", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24127;Q95TY3", "ec_number_list": "1.14.-.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VS79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VS97-1", "uniprot_id": "PGPSD_DROME", "mass": 20123.0, "length": 186, "protein_name": "Peptidoglycan-recognition protein SD", "gene_name": "PGRP-SD", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein SD", "refseq_ac": "NP_648145", "gene_names_uniprotkb": "PGRP-SD; CG7496", "gene_names_refseq": "CG7496; Dm PGRP-SD; Dmel\\CG7496; PGRP-SD; pgrp-sd", "protein_names_uniprotkb": "Peptidoglycan-recognition protein SD", "protein_names_refseq": "CG7496-PA; PGRP-SD-PA; Peptidoglycan-recognition protein-SD precursor; peptidoglycan recognition protein SD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7496); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;11106397;12032070;12537572;14738318;15448690", "class_list": "", "function": "Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q70PS3;Q70PS6;Q70PS9", "ec_number_list": "", "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0032499 detection of peptidoglycan", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VS97-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSB9-1", "uniprot_id": "TMM43_DROME", "mass": 42773.0, "length": 376, "protein_name": "Transmembrane protein 43 homolog", "gene_name": "Tmem43", "organism": "Fruit fly", "refseq_name": "transmembrane protein 43", "refseq_ac": "NP_648162", "gene_names_uniprotkb": "Tmem43; CG8111", "gene_names_refseq": "CG8111; Dmel\\CG8111; Tmem43", "protein_names_uniprotkb": "Transmembrane protein 43 homolog", "protein_names_refseq": "CG8111-PA; Tmem43-PA; transmembrane protein 43", "tax_id": 7227, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); autosomal dominant Emery-Dreifuss muscular dystrophy 7 (Disease Ontology:DOID:0070252); arrhythmogenic right ventricular dysplasia 5 (Disease Ontology:DOID:0110074); autosomal dominant auditory neuropathy 3 (Disease Ontology:DOID:0112373)", "pathway": " (dme:Dmel_CG8111)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;35869176", "class_list": "", "function": "Involved in lipid metabolism and utilization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJL3;Q8SZN7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0071763 nuclear membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VSB9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSC1-1", "uniprot_id": "SRP09_DROME", "mass": 8974.0, "length": 77, "protein_name": "Signal recognition particle 9 kDa protein", "gene_name": "Srp9", "organism": "Fruit fly", "refseq_name": "signal recognition particle 9", "refseq_ac": "NP_648163", "gene_names_uniprotkb": "Srp9; CG8268", "gene_names_refseq": "CG8268; Dmel\\CG8268; SRP9; Srp9", "protein_names_uniprotkb": "Signal recognition particle 9 kDa protein; SRP9", "protein_names_refseq": "CG8268-PA; Srp9-PA; signal recognition particle 9; signal recognition particle protein 9", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8268); (R-DME-1799339)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15901661", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). SRP9 together with Srp14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP (By similarity). The complex of Srp9 and Srp14 is required for SRP RNA binding (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005829 cytosol", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0045900 negative regulation of translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VSC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSH2-1", "uniprot_id": "GR66A_DROME", "mass": 59081.0, "length": 527, "protein_name": "Gustatory receptor for bitter taste 66a", "gene_name": "Gr66a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 66a", "refseq_ac": "NP_523971", "gene_names_uniprotkb": "Gr66a; CG7189", "gene_names_refseq": "CG7189; Dmel\\CG7189; GR66A; GR66C1; GR66a; Gr66A; Gr66C1; Gr66a; Gr66", "protein_names_uniprotkb": "Gustatory receptor for bitter taste 66a", "protein_names_refseq": "CG7189-PB; Gr66a-PB; gustatory receptor 66C1; gustatory receptor 66a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7189)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;11516643;12537572;15202999;16423701;16979558;19246397;19618260;20797533;22031876;22279227;22798487", "class_list": "", "function": "Gustatory receptor required for response to the bitter in taste neurons. Gr66a cells respond to bitter compounds such as caffeine, theophylline, threonine or valine. Flies avoid bitter substances, suggesting that Gr66a neuron activity is sufficient to mediate avoidance behavior. Required for sensing and avoiding N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide, as well as to L-canavanine, a plant-derived insecticide. Gr66a neurons are also involved in the sex-specific perception of molecules inducing male avoidance behavior, probably through sensing 7-tricosene (7-T), a male cuticular pheromone and leading to inhibition of male-male courtship. Finally, also plays a role in oviposition behavior, in which females evaluate their environment and choose to lay eggs on substrates they may find aversive in other contexts., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity;GO:0170021 ionotropic taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0031000 response to caffeine;GO:0034220 monoatomic ion transmembrane transport;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VSH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSH9-1", "uniprot_id": "PHAF1_DROME", "mass": 49264.0, "length": 438, "protein_name": "PHAF1 protein CG7083", "gene_name": "CG7083", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_648211", "gene_names_uniprotkb": "CG7083", "gene_names_refseq": "CG7083; Dmel\\CG7083", "protein_names_uniprotkb": "PHAF1 protein CG7083", "protein_names_refseq": "CG7083-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7083)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "May play a regulatory role in autophagic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WHJ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005802 trans-Golgi network;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VSH9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSS2-1", "uniprot_id": "SRP68_DROME", "mass": 69009.0, "length": 604, "protein_name": "Signal recognition particle subunit SRP68", "gene_name": "Srp68", "organism": "Fruit fly", "refseq_name": "signal recognition particle 68", "refseq_ac": "NP_648273", "gene_names_uniprotkb": "Srp68; CG5064", "gene_names_refseq": "CG5064; Dmel\\CG5064; SRP68; Srp68", "protein_names_uniprotkb": "Signal recognition particle subunit SRP68; SRP68; Signal recognition particle 68 kDa protein", "protein_names_refseq": "CG5064-PA; Srp68-PA; signal recognition particle 68; signal recognition particle protein 68", "tax_id": 7227, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590)", "pathway": " (dme:Dmel_CG5064); (R-DME-1799339)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15901661", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), Srp72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0030942 endoplasmic reticulum signal peptide binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VSS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSY6-1", "uniprot_id": "SERB_DROME", "mass": 29218.0, "length": 270, "protein_name": "Phosphoserine phosphatase", "gene_name": "aay", "organism": "Fruit fly", "refseq_name": "astray", "refseq_ac": "NP_524001", "gene_names_uniprotkb": "aay; CG3705; astray", "gene_names_refseq": "0423/14; 24661601; Aay; CG3705; Dmel\\CG3705; aay; anon-WO0172774.117", "protein_names_uniprotkb": "Phosphoserine phosphatase; 3.1.3.3; O-phosphoserine phosphohydrolase; PSPase; PSP", "protein_names_refseq": "3-phosphoserine phosphatase; CG3705-PA; aay-PA; astray", "tax_id": 7227, "disease": "PSPH deficiency (Disease Ontology:DOID:0050724); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG3705); (R-DME-977347)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;11102367;12537569;12537572", "class_list": "", "function": "Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9U4B0", "ec_number_list": "3.1.3.3", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0036424 L-phosphoserine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006563 L-serine metabolic process;GO:0006564 L-serine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VSY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VSZ3-1", "uniprot_id": "Q9VSZ3_DROME", "mass": 73208.0, "length": 669, "protein_name": "Pleiohomeotic like, isoform A; Pleiohomeotic like, isoform B", "gene_name": "phol", "organism": "Fruit fly", "refseq_name": "pleiohomeotic like, isoform B", "refseq_ac": "NP_001287005", "gene_names_uniprotkb": "phol; CG3445; Dmel\\CG3445; Dmel_CG3445; PHOL; Pho1; Phol", "gene_names_refseq": "CG3445; Dmel\\CG3445; PHOL; Pho1; Phol; phol", "protein_names_uniprotkb": "Pleiohomeotic like, isoform A; Pleiohomeotic like, isoform B", "protein_names_refseq": "CG3445-PB; Pleiohomeotic-like; pho-like; phol-PB; pleiohomeotic like, isoform B; pleiohomeotic like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3445)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VSZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VT04-1", "uniprot_id": "PATH_DROME", "mass": 52056.0, "length": 471, "protein_name": "Proton-coupled amino acid transporter-like protein pathetic", "gene_name": "path", "organism": "Fruit fly", "refseq_name": "pathetic, isoform D", "refseq_ac": "NP_001261634", "gene_names_uniprotkb": "path; CG3424; Dmel\\CG3424; Dmel_CG3424; Pathetic; Path; anon-WO0118547.271; anon-WO0118547.370; pth", "gene_names_refseq": "CG3424; Dmel\\CG3424; Pathetic; Path; anon-WO0118547.271; anon-WO0118547.370; path; pth", "protein_names_uniprotkb": "Proton-coupled amino acid transporter-like protein pathetic", "protein_names_refseq": "CG3424-PD; path-PD; pathetic, isoform D; pathetic", "tax_id": 7227, "disease": "iminoglycinuria (Disease Ontology:DOID:0112265)", "pathway": " (dme:Dmel_CG3424); (R-DME-352230); (R-DME-428559); (R-DME-71240)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15843412;16110336;17569856;17569867;22574197;25589440;26063572;26109356;26109357;26735916", "class_list": "", "function": "Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline (PubMed:15843412). Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway (PubMed:15843412, PubMed:22574197). Required in a cell-autonomous manner for dendrite growth in neurons with large dendrite arbors (PubMed:26063572, PubMed:26735916)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0032536 regulation of cell projection size;GO:0040008 regulation of growth;GO:0048813 dendrite morphogenesis;GO:0097484 dendrite extension;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VT04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VT20-1", "uniprot_id": "OR67B_DROME", "mass": 49516.0, "length": 421, "protein_name": "Odorant receptor 67b", "gene_name": "Or67b", "organism": "Fruit fly", "refseq_name": "odorant receptor 67b", "refseq_ac": "NP_524007", "gene_names_uniprotkb": "Or67b; CG14176", "gene_names_refseq": "67B.2; 67b; CG14176; DmOr67b; Dmel\\CG14176; OR67b; Or67b", "protein_names_uniprotkb": "Odorant receptor 67b", "protein_names_refseq": "CG14176-PB; Or67b-PB; odorant receptor 67b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14176)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;20628035;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate, pentyl acetate, methyl caproate, anisole, heptanal, 2-heptanone, r-carvone, nonanoic acid, and pyrazines., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3I3", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VT20-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VT41-1", "uniprot_id": "INT7_DROME", "mass": 112288.0, "length": 1001, "protein_name": "Integrator complex subunit 7", "gene_name": "defl", "organism": "Fruit fly", "refseq_name": "deflated", "refseq_ac": "NP_648352", "gene_names_uniprotkb": "defl; CG18176; IntS7", "gene_names_refseq": "CG18176; Dmel\\CG18176; Int7; IntS7; defl", "protein_names_uniprotkb": "Integrator complex subunit 7; Protein deflated", "protein_names_refseq": "CG18176-PA; defl-PA; deflated; integrator 7", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18176); (R-DME-6807505)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10731132;12537569;12537572;19326441;21078872;23097424;31530651;32966759;37995689;39032490", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:21078872, PubMed:23097424, PubMed:32966759). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity (PubMed:32966759). The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q961P9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9VT41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VT67-1", "uniprot_id": "HEZ_DROME", "mass": 20802.0, "length": 186, "protein_name": "LSM12 homolog B", "gene_name": "Hez", "organism": "Fruit fly", "refseq_name": "hezron, isoform B", "refseq_ac": "NP_001097566", "gene_names_uniprotkb": "Hez; CG14164; Lsm12b", "gene_names_refseq": "CG14164; Dmel\\CG14164; Gem6; Hez; Lsm12b", "protein_names_uniprotkb": "LSM12 homolog B; Protein Hezron", "protein_names_refseq": "CG14164-PB; Gemin6; Hez-PB; hezron, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14164)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;28949413;30563832", "class_list": "", "function": "May have an accessory function in the survival motor neuron (SMN) complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JNP9;Q4V5R7;Q4V5V2;Q4V5X6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VT67-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VTF9-1", "uniprot_id": "UFD1_DROME", "mass": 34792.0, "length": 316, "protein_name": "Ubiquitin fusion degradation protein 1 homolog", "gene_name": "Ufd1", "organism": "Fruit fly", "refseq_name": "ubiquitin fusion-degradation 1-like", "refseq_ac": "NP_524023", "gene_names_uniprotkb": "Ufd1; CG6233; UFD1L; Ufd1-like", "gene_names_refseq": "CG6233; Dmel\\CG6233; UFD1; Udf1; UfD1-like; Ufd-1; Ufd1 like; Ufd1-like; Ufd1L; Ufd1; anon-WO0118547.405; dUFD1L; dUfd1; ufd1-like; ufd1", "protein_names_uniprotkb": "Ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1; Ubiquitin fusion-degradation 1-like", "protein_names_refseq": "CG6233-PA; UfD1-like; Ufd1-PA; ubiquitin fusion-degradation 1-like; ubiquitin fusion-degradation", "tax_id": 7227, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583); neurodegenerative disease (Disease Ontology:DOID:1289); schizophrenia (Disease Ontology:DOID:5419); cleft palate (Disease Ontology:DOID:674)", "pathway": " (dme:Dmel_CG6233); (R-DME-110320); (R-DME-5689880); (R-DME-8951664); (R-DME-9755511)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;11435701;12537569;12537572", "class_list": "", "function": "Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0000502 proteasome complex", "go_biological_process": "GO:0006508 proteolysis;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VTF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VTI8-1", "uniprot_id": "CHRB_DROME", "mass": 32179.0, "length": 299, "protein_name": "Protein charybde", "gene_name": "chrb", "organism": "Fruit fly", "refseq_name": "charybde, isoform C", "refseq_ac": "NP_648470", "gene_names_uniprotkb": "chrb; BcDNA:GH09771; CG7533; Charybde; Charybdis; Chrb; Dmel\\CG7533; Dmel_CG7533; EP(3)1035; anon-EST:Liang-2.51; char; clone 2.51", "gene_names_refseq": "BcDNA:GH09771; CG7533; Charybde; Charybdis; Chrb; Dmel\\CG7533; EP(3)1035; anon-EST:Liang-2.51; char; chrb; clone 2.51", "protein_names_uniprotkb": "Protein charybde; Protein charybdis; Protein regulated in development and DNA damage response 1; REDD-1", "protein_names_refseq": "CG7533-PC; charybde, isoform C; charybdis; chrb-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7533); (R-DME-5628897)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12453409;12537568;12537569;12537572;12537573;12537574;15545626;15632201;16110336;16423342;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as a cell death activator during head development., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9NHN5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006915 apoptotic process;GO:0009968 negative regulation of signal transduction;GO:0032006 regulation of TOR signaling;GO:0045926 negative regulation of growth", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VTI8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VTM5-1", "uniprot_id": "TFB1M_DROME", "mass": 38101.0, "length": 330, "protein_name": "Dimethyladenosine transferase 1, mitochondrial", "gene_name": "mtTFB1", "organism": "Fruit fly", "refseq_name": "mitochondrial transcription factor B1", "refseq_ac": "NP_648499", "gene_names_uniprotkb": "mtTFB1; CG42631", "gene_names_refseq": "CG42631; CG7319; Dmel\\CG42631; TFB1; d-TFB1M; d-mtTFB1; mtTFB1", "protein_names_uniprotkb": "Dimethyladenosine transferase 1, mitochondrial; 2.1.1.-; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial transcription factor B1; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; d-mtTFB1", "protein_names_refseq": "CG42631-PA; mitochondrial transcription factor B1; mitochondrial translation factor B1; mtTFB1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42631)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15749697", "class_list": "", "function": "Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. In contrast to mtTFB2, it does not have a critical role in either transcription or regulation of the copy number of mitochondrial DNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0G5;Q7KUF8;Q8T013", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0031167 rRNA methylation;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VTM5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VTP4-1", "uniprot_id": "R10AB_DROME", "mass": 24274.0, "length": 217, "protein_name": "Large ribosomal subunit protein uL1", "gene_name": "RpL10Ab", "organism": "Fruit fly", "refseq_name": "ribosomal protein L10Ab, isoform A", "refseq_ac": "NP_648514", "gene_names_uniprotkb": "RpL10Ab; CG7283", "gene_names_refseq": "BcDNA:RH06366; CG7283; Dmel\\CG7283; L10Ab; L1; RpL10Ab; RpL10Ae; RpL10A; RpL10a; RpL10; Rpl10ab; Rpl10a; anon-EST:Posey188", "protein_names_uniprotkb": "Large ribosomal subunit protein uL1; 60S ribosomal protein L10a-2", "protein_names_refseq": "CG7283-PA; RpL10Ab-PA; ribosomal protein L10Ab, isoform A; ribosomal protein L10Ab", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7283); (R-DME-156827); (R-DME-1799339); (R-DME-72689); (R-DME-72706); (R-DME-975956); (R-DME-975957); (R-DME-9954709); (R-DME-9954714); (R-DME-9954716)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "10731132;12537572;23636399", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:1904262 negative regulation of TORC1 signaling;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VTP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VTU1-1", "uniprot_id": "APG12_DROME", "mass": 12348.0, "length": 111, "protein_name": "Autophagy protein 12-like", "gene_name": "Atg12", "organism": "Fruit fly", "refseq_name": "Autophagy-related 12", "refseq_ac": "NP_648551", "gene_names_uniprotkb": "Atg12; CG10861", "gene_names_refseq": "ATG12; Atg12; CG10861; Dmel\\CG10861; atg12", "protein_names_uniprotkb": "Autophagy protein 12-like; APG12-like", "protein_names_refseq": "Atg12-PB; Autophagy-related 12; Autophagy-specific gene 12; CG10861-PB; autophagy related protein 12", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547)", "pathway": " (dme:Dmel_CG10861); (R-DME-1632852)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;15296714", "class_list": "", "function": "Required for autophagy., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V6A9", "ec_number_list": "", "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0034045 phagophore assembly site membrane;GO:0034274 Atg12-Atg5-Atg16 complex", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VTU1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VU41-1", "uniprot_id": "ZMY10_DROME", "mass": 51634.0, "length": 451, "protein_name": "Zinc finger MYND domain-containing protein 10 homolog", "gene_name": "Zmynd10", "organism": "Fruit fly", "refseq_name": "zinc finger MYND-type containing 10", "refseq_ac": "NP_648625", "gene_names_uniprotkb": "Zmynd10; CG11253", "gene_names_refseq": "CG11253; Dmel\\CG11253; Zmynd10", "protein_names_uniprotkb": "Zinc finger MYND domain-containing protein 10 homolog", "protein_names_refseq": "CG11253-PA; ZMYND10 homolog; Zmynd10-PA; zinc finger MYND-type containing 10", "tax_id": 7227, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); primary ciliary dyskinesia 22 (Disease Ontology:DOID:0110597); sensorineural hearing loss (Disease Ontology:DOID:10003); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (dme:Dmel_CG11253)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;23891471", "class_list": "", "function": "Plays a role in axonemal structure organization and motility. May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZ82", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0043025 neuronal cell body;GO:0034451 centriolar satellite;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007605 sensory perception of sound;GO:0044458 motile cilium assembly;GO:0036158 outer dynein arm assembly;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VU41-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VU68-1", "uniprot_id": "WDR1_DROME", "mass": 66550.0, "length": 608, "protein_name": "Actin-interacting protein 1", "gene_name": "flr", "organism": "Fruit fly", "refseq_name": "flare, isoform A", "refseq_ac": "NP_648642", "gene_names_uniprotkb": "flr; CG10724", "gene_names_refseq": "AIP1; Aip1; CG10724; Dmel\\CG10724; Flare; aip1; flr", "protein_names_uniprotkb": "Actin-interacting protein 1; AIP1; Protein flare", "protein_names_refseq": "AIP1; CG10724-PA; actin interacting protein 1; actin-interacting protein 1; flare hair; flare, isoform A; flare-3; flr-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10724); (R-DME-114608)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15952742;17565945;25308079", "class_list": "", "function": "Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:17565945). Together with GMF, promotes Arp2/3-nucleated actin filament array disassembly (PubMed:25308079). Essential for organismal and cell viability (PubMed:17565945). Required for the development of normal wing cell planar polarity (PubMed:17565945). In egg chambers and together with GMF, plays an important role in directional migration of border cell clusters (PubMed:25308079)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IQJ6", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0030834 regulation of actin filament depolymerization;GO:0045214 sarcomere organization;GO:0040011 locomotion;GO:0030833 regulation of actin filament polymerization;GO:0001736 establishment of planar polarity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VU68-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VU70-1", "uniprot_id": "TTC36_DROME", "mass": 20667.0, "length": 185, "protein_name": "Tetratricopeptide repeat protein 36 homolog", "gene_name": "CG14105", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_648644", "gene_names_uniprotkb": "CG14105", "gene_names_refseq": "CG14105; Dmel\\CG14105", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 36 homolog; TPR repeat protein 36 homolog", "protein_names_refseq": "CG14105-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14105)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C5WLP7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VU70-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VU84-1", "uniprot_id": "DBNL_DROME", "mass": 58729.0, "length": 531, "protein_name": "Drebrin-like protein", "gene_name": "Abp1", "organism": "Fruit fly", "refseq_name": "actin binding protein 1", "refseq_ac": "NP_648657", "gene_names_uniprotkb": "Abp1; CG10083", "gene_names_refseq": "Abp1; CG10083; Dmel\\CG10083; abp1", "protein_names_uniprotkb": "Drebrin-like protein; Actin binding protein 1", "protein_names_refseq": "Abp1-PA; CG10083-PA; Drebrin-like; actin binding protein 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10083)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;10908588;12537569;12537572;12975351;17372656;18327897;40245499", "class_list": "", "function": "Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin (By similarity). Does not seem to be involved in actin-based lamella protrusion during cell migration., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRS9", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0051015 actin filament binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0014069 postsynaptic density;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0072553 terminal button organization;GO:0048812 neuron projection morphogenesis;GO:0098974 postsynaptic actin cytoskeleton organization;GO:0045773 positive regulation of axon extension;GO:0045887 positive regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9VU84-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VUA0-1", "uniprot_id": "GPTC1_DROME", "mass": 107899.0, "length": 952, "protein_name": "G patch domain-containing protein 1 homolog", "gene_name": "CG8833", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_648669", "gene_names_uniprotkb": "CG8833", "gene_names_refseq": "CG8833; Dmel\\CG8833; GPTC1", "protein_names_uniprotkb": "G patch domain-containing protein 1 homolog", "protein_names_refseq": "CG8833-PA; uncharacterized protein", "tax_id": 7227, "disease": "progressive myoclonus epilepsy 3 (Disease Ontology:DOID:0111446)", "pathway": " (dme:Dmel_CG8833); (R-DME-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C1C3H2;Q95RM7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VUA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VUN0-1", "uniprot_id": "TOLL6_DROME", "mass": 170158.0, "length": 1514, "protein_name": "Toll-like receptor 6", "gene_name": "Toll-6", "organism": "Fruit fly", "refseq_name": "Toll-6, isoform B", "refseq_ac": "NP_001246765", "gene_names_uniprotkb": "Toll-6; CG7250; Tl-6", "gene_names_refseq": "18w-like; CG7250; CT22359; Dmel\\CG7250; TOLL 6; Tl-6; Toll 6; Toll-6; Toll6; Toll; dTLR6; dToll6; toll-6; toll", "protein_names_uniprotkb": "Toll-like receptor 6", "protein_names_refseq": "CG7250-PB; Toll-6, isoform B; Toll-6-PB; toll receptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7250); (R-DME-376176); (R-DME-428890); (R-DME-9010553)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10731132;10973475;12537572;12617819;21158756;23892553;25363762;25741726", "class_list": "", "function": "Toll-related receptor which binds to the neurotrophin spz5 (PubMed:10973475, PubMed:23892553). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1) (PubMed:25741726). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q6NN49;Q9NBK9", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0048495 Roundabout binding;GO:0005030 neurotrophin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0048167 regulation of synaptic plasticity;GO:0007411 axon guidance;GO:0003401 axis elongation;GO:0060026 convergent extension", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VUN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VUR3-1", "uniprot_id": "AIMP2_DROME", "mass": 36934.0, "length": 334, "protein_name": "Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2", "gene_name": "AIMP2", "organism": "Fruit fly", "refseq_name": "aaRS-interacting multifunctional protein 2, isoform A", "refseq_ac": "NP_648782", "gene_names_uniprotkb": "AIMP2; CG12304", "gene_names_refseq": "AIMP2; CG12304; Dmel\\CG12304; p38", "protein_names_uniprotkb": "Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Probable multisynthase complex auxiliary component p38; aaRS-interacting multifunctional protein 2", "protein_names_refseq": "AIMP2-PA; CG12304-PA; aaRS-interacting multifunctional protein 2, isoform A; aminoacyl-tRNA synthetase-interacting multifunctional protein 2", "tax_id": 7227, "disease": "hypomyelinating leukodystrophy 17 (Disease Ontology:DOID:0070404)", "pathway": " (dme:Dmel_CG12304); (R-DME-9856649)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Required for assembly and stability of the aminoacyl-tRNA synthase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VUR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VUR7-1", "uniprot_id": "PHLP1_DROME", "mass": 30976.0, "length": 276, "protein_name": "Phosducin-like protein 1", "gene_name": "PhLP1", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_648786", "gene_names_uniprotkb": "PhLP1; CG7650", "gene_names_refseq": "BcDNA:AT27057; CG7650; Dmel\\CG7650", "protein_names_uniprotkb": "Phosducin-like protein 1; PHLP", "protein_names_refseq": "CG7650-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7650); (R-DME-6814122)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17372656;18327897", "class_list": "", "function": "Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T3W9", "ec_number_list": "", "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VUR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VUV9-1", "uniprot_id": "U520_DROME", "mass": 244510.0, "length": 2142, "protein_name": "U5 small nuclear ribonucleoprotein 200 kDa helicase", "gene_name": "Brr2", "organism": "Fruit fly", "refseq_name": "Brr2 U5 snRNP complex subunit", "refseq_ac": "NP_648818", "gene_names_uniprotkb": "Brr2; CG5931; l(3)72Ab", "gene_names_refseq": "ASCC3L1; Brr2; CG5931; Dmel\\CG5931; anon-EST:Liang-1.21; brr2; cg5931; clone 1.21; l(3)72Ab", "protein_names_uniprotkb": "U5 small nuclear ribonucleoprotein 200 kDa helicase; 3.6.4.13; Protein lethal (3) 72Ab", "protein_names_refseq": "Brr2 U5 snRNP complex subunit; Brr2-PA; CG5931-PA; lethal (3) 72Ab", "tax_id": 7227, "disease": "retinitis pigmentosa 33 (Disease Ontology:DOID:0110366); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dme:Dmel_CG5931); (R-DME-72163); (R-DME-72165)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (By similarity). Plays a role in pre-mRNA splicing (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U0X1;Q8T9I9", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;2.7.7.6;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;5.2.1.8;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0030532 small nuclear ribonucleoprotein complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11);GO:0007419 ventral cord development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VUV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVF7-1", "uniprot_id": "MIP_DROME", "mass": 23412.0, "length": 211, "protein_name": "Allatostatins MIP", "gene_name": "Mip", "organism": "Fruit fly", "refseq_name": "myoinhibiting peptide precursor", "refseq_ac": "NP_648971", "gene_names_uniprotkb": "Mip; CG6456", "gene_names_refseq": "ASB; AST-B; Ast-B; AstB-1; AstB/MIP; AstB; CG6456; DAP-B; DmMIP1; DmMIP2; DmMIP3; DmMIP4; DmMIP5; Dmel\\CG6456; Drm-MIP-1; Drm-MIP-2; Drm-MIP-3; Drm-MIP-4; Drm-MIP-5; Drm-MIP; MIP-1; MIP-2; MIP-3; MIP-4; MIP-5; MIP1; MIP2; MIP3; MIP4; MIP5; MIP; Mip; mip", "protein_names_uniprotkb": "Allatostatins MIP; B-type Allostatin preprohormone; MIP-1; MIP-2; MIP-3; MIP-4; MIP-5; Myoinhibitory-like protein", "protein_names_refseq": "CG6456-PA; Drostatin-B1; Drostatin-B3; Drostatin-B4; Drostatin-B5; Mip-PA; Mip-like peptide; allatostatin (B-type); allatostatin B-1; allatostatin cricket-type; allatostatin-B1; allatostatin-B; allostatin B; drostatin-B2; mioinhibiting peptide precursor; myoinhibiting peptide precursor; myoinhibiting peptide; myoinhibitory peptide", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6456)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10731132;11181081;12171930;12537572;19319573;20308537;20458515;21174124;21214272;25333796", "class_list": "", "function": "Ligand for the sex peptide receptor (SPR) (PubMed:20308537, PubMed:20458515, PubMed:25333796). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat (PubMed:25333796). May also have a regulatory role in gut motility (PubMed:11181081)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0045968 negative regulation of juvenile hormone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9VVF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVI2-1", "uniprot_id": "EDC3_DROME", "mass": 73415.0, "length": 680, "protein_name": "Enhancer of mRNA-decapping protein 3", "gene_name": "Edc3", "organism": "Fruit fly", "refseq_name": "enhancer of decapping 3", "refseq_ac": "NP_648992", "gene_names_uniprotkb": "Edc3; CG6311", "gene_names_refseq": "CG6311; DmEDC3; Dmel\\CG6311; EDC3; Edc3; LSM16; LSm16; Lsm16", "protein_names_uniprotkb": "Enhancer of mRNA-decapping protein 3", "protein_names_refseq": "CG6311-PB; Edc3-PB; enhancer of decapping 3; enhancer of decapping-3", "tax_id": 7227, "disease": "autosomal recessive intellectual developmental disorder 50 (Disease Ontology:DOID:0081213)", "pathway": " (dme:Dmel_CG6311); (R-DME-430039)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;17923697;18327897;18765641;19285948;31114929", "class_list": "", "function": "In the process of mRNA degradation, may play a role in mRNA decapping., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T042;Q95SZ2", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006402 mRNA catabolic process;GO:0033962 P-body assembly;GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VVI2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVL6-1", "uniprot_id": "MED19_DROME", "mass": 35390.0, "length": 337, "protein_name": "Mediator of RNA polymerase II transcription subunit 19", "gene_name": "MED19", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 19, isoform B", "refseq_ac": "NP_001287103", "gene_names_uniprotkb": "MED19; CG5546; Dmel\\CG5546; Dmel_CG5546; Med19", "gene_names_refseq": "CG5546; Dmel\\CG5546; MED19; Med19", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 19; Mediator complex subunit 19", "protein_names_refseq": "CG5546-PB; MED19-PB; mediator complex subunit 19, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5546)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VVL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVR4-1", "uniprot_id": "BGBP2_DROME", "mass": 52856.0, "length": 461, "protein_name": "Gram-negative bacteria-binding protein 2", "gene_name": "GNBP2", "organism": "Fruit fly", "refseq_name": "Gram-negative bacteria binding protein 2, isoform B", "refseq_ac": "NP_524141", "gene_names_uniprotkb": "GNBP2; CG4144", "gene_names_refseq": "CG4144; DGNBP-2; Dmel\\CG4144; GNBP2; GNBP; gnbp2", "protein_names_uniprotkb": "Gram-negative bacteria-binding protein 2", "protein_names_refseq": "CG4144-PB; GNBP2-PB; Gram-negative bacteria binding protein 2, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4144)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10827089;12537569;12537572;17103056", "class_list": "", "function": "Involved in the recognition of invading microorganisms. Binds specifically to beta-1,3-glucan and activates the phenoloxidase cascade (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0ZWZ5;A0ZWZ8;A0ZX11;A0ZX12;A0ZX13;A0ZX39;A0ZX40;A0ZX41;A0ZX42;Q8IQT6;Q8IQT7;Q95U68;Q9NHA9", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0001872 (1->3)-beta-D-glucan binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0045087 innate immune response;GO:0005975 carbohydrate metabolic process;GO:0002758 innate immune response-activating signaling pathway;GO:0045088 regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VVR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VVU5-1", "uniprot_id": "CSN1_DROME", "mass": 58215.0, "length": 525, "protein_name": "COP9 signalosome complex subunit 1b", "gene_name": "CSN1b", "organism": "Fruit fly", "refseq_name": "COP9 signalosome subunit 1b", "refseq_ac": "NP_524152", "gene_names_uniprotkb": "CSN1b; CG3889", "gene_names_refseq": "CG3889; CH1-2; CSN1B; CSN1b; CSN1; Csn1B; Csn1b; DCH1-2; Dch1-2; Dch1; Dmel\\CG3889; csn1b; csn1; dCSN1", "protein_names_uniprotkb": "COP9 signalosome complex subunit 1b; Dch1-2; Signalosome subunit 1b", "protein_names_refseq": "CG3889-PA; COP9 complex homolog subunit 1 b; COP9 complex homolog subunit 1-2; COP9 signalosome subunit 1b; CSN1b-PA; drosophila COP9 signalosome homolog 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3889); (R-DME-5696394); (R-DME-6781823); (R-DME-8856825); (R-DME-8951664); (R-DME-9013422)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10531038;10731132;12537569;12537572;12737805", "class_list": "", "function": "Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9XYW3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0050821 protein stabilization;GO:0007281 germ cell development;GO:0048140 male germ-line cyst encapsulation;GO:0048142 germarium-derived cystoblast division;GO:2000434 regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VVU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VW12-1", "uniprot_id": "U389_DROME", "mass": 14104.0, "length": 125, "protein_name": "UPF0389 protein CG9231", "gene_name": "Dmel\\CG9231", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001287120", "gene_names_uniprotkb": "Dmel\\CG9231; CG9231; Dmel_CG9231", "gene_names_refseq": "CG9231; Dmel\\CG9231", "protein_names_uniprotkb": "UPF0389 protein CG9231", "protein_names_refseq": "CG9231-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9231)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17893096;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0071456 cellular response to hypoxia;GO:0090200 positive regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VW12-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VW14-1", "uniprot_id": "MRM3_DROME", "mass": 45044.0, "length": 407, "protein_name": "rRNA methyltransferase 3, mitochondrial", "gene_name": "CG14100", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_649130", "gene_names_uniprotkb": "CG14100", "gene_names_refseq": "CG14100; Dmel\\CG14100", "protein_names_uniprotkb": "rRNA methyltransferase 3, mitochondrial; 2.1.1.-; RNA methyltransferase-like protein 1; rRNA (guanosine-2'-O)-methyltransferase", "protein_names_refseq": "CG14100-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14100)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;25009282", "class_list": "", "function": "S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1580 (Gm1580) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Also required for formation of 2'-O-methyluridine at position 1579 (Um1579) mediated by MRM2., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZ70", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity;GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006364 rRNA processing;GO:1902775 mitochondrial large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VW14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VW53-1", "uniprot_id": "Q9VW53_DROME", "mass": 36612.0, "length": 326, "protein_name": "Mtr3", "gene_name": "Mtr3", "organism": "Fruit fly", "refseq_name": "Mtr3", "refseq_ac": "NP_649157", "gene_names_uniprotkb": "Mtr3; CG8025; Dmel\\CG8025; Dmel_CG8025; dMtr3; mtr3", "gene_names_refseq": "CG8025; Dmel\\CG8025; Mtr3; dMtr3; mtr3", "protein_names_uniprotkb": "Mtr3", "protein_names_refseq": "CG8025-PA; Mtr3-PA; Mtr3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8025); (R-DME-429958); (R-DME-450385); (R-DME-450513); (R-DME-6791226); (R-DME-9930044)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0010468 regulation of gene expression;GO:0006364 rRNA processing;GO:0016075 rRNA catabolic process;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VW53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWA2-1", "uniprot_id": "DCTD_DROME", "mass": 22857.0, "length": 203, "protein_name": "Probable deoxycytidylate deaminase", "gene_name": "CG6951", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": "NP_649197", "gene_names_uniprotkb": "CG6951", "gene_names_refseq": "CG6951; Dmel\\CG6951; anon-WO0118547.579", "protein_names_uniprotkb": "Probable deoxycytidylate deaminase; 3.5.4.12; dCMP deaminase", "protein_names_refseq": "CG6951-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6951); (R-DME-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Supplies the nucleotide substrate for thymidylate synthetase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53XF4", "ec_number_list": "3.5.4.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004132 dCMP deaminase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0006231 dTMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VWA2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWB0-1", "uniprot_id": "TECPR_DROME", "mass": 149486.0, "length": 1350, "protein_name": "Tectonin beta-propeller repeat-containing protein", "gene_name": "Pex23", "organism": "Fruit fly", "refseq_name": "peroxin 23", "refseq_ac": "NP_730508", "gene_names_uniprotkb": "Pex23; CG32226", "gene_names_refseq": "CDI11; CG18565; CG32226; CG6468; Cdi11; DmelPex23; Dmel\\CG32226; Pex23; cdi11", "protein_names_uniprotkb": "Tectonin beta-propeller repeat-containing protein; Peroxin-23 protein", "protein_names_refseq": "CG32226-PA; Cyclin-dependent kinase interactor 11; Pex23-PA; peroxin 23", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32226)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21669930", "class_list": "", "function": "Involved in peroxisome biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D0Z772", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098588 bounding membrane of organelle", "go_biological_process": "GO:0007031 peroxisome organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VWB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWE9-1", "uniprot_id": "S61G2_DROME", "mass": 7596.0, "length": 68, "protein_name": "Protein transport protein Sec61 gamma-2 subunit", "gene_name": "Sec61gamma", "organism": "Fruit fly", "refseq_name": "Sec61 gamma subunit, isoform B", "refseq_ac": "NP_001285450", "gene_names_uniprotkb": "Sec61gamma; CG14214; Dmel\\CG14214; Dmel_CG14214; SEC61G2; Sec61", "gene_names_refseq": "CG14214; Dmel\\CG14214; Sec61gamma; Sec61", "protein_names_uniprotkb": "Protein transport protein Sec61 gamma-2 subunit", "protein_names_refseq": "CG14214-PB; Sec61 gamma subunit, isoform B; Sec61gamma-PB", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG14214); (R-DME-9609523)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Necessary for protein translocation in the endoplasmic reticulum., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005784 Sec61 translocon complex;GO:0071261 Ssh1 translocon complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010507 negative regulation of autophagy;GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0006886 intracellular protein transport;GO:0006605 protein targeting", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VWE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWI4-1", "uniprot_id": "NARYA_DROME", "mass": 24623.0, "length": 211, "protein_name": "RING finger protein narya", "gene_name": "narya", "organism": "Fruit fly", "refseq_name": "narya", "refseq_ac": "NP_573383", "gene_names_uniprotkb": "narya; CG12200", "gene_names_refseq": "CG12200; Dmel\\CG12200; Narya; narya", "protein_names_uniprotkb": "RING finger protein narya", "protein_names_refseq": "CG12200-PA; narya-PA; narya", "tax_id": 7227, "disease": "spermatogenic failure (Disease Ontology:DOID:0111910); spermatogenic failure 62 (Disease Ontology:DOID:0112351)", "pathway": " (dme:Dmel_CG12200)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;30615609", "class_list": "", "function": "Required for the formation of DNA double-strand breaks (DSBs) together with nenya and vilya during the meiotic recombination process (PubMed:30615609). Plays a role in DSBs processing into crossovers (PubMed:30615609). Plays a redundant role with nenya in chromosome segregation during female meiosis (PubMed:30615609)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7K4P2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0035861 site of double-strand break;GO:0005694 chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination;GO:1903343 positive regulation of meiotic DNA double-strand break formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VWI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWR5-1", "uniprot_id": "CP306_DROME", "mass": 65177.0, "length": 574, "protein_name": "Cytochrome P450 306a1", "gene_name": "phtm", "organism": "Fruit fly", "refseq_name": "phantom, isoform B", "refseq_ac": "NP_001285414", "gene_names_uniprotkb": "phtm; 306a1; CG6578; CYP306A1; Cyp306a1-Dm; Cyp306a1; Dmel\\CG6578; Dmel_CG6578; Phm; exo; phm; ptm", "gene_names_refseq": "306a1; CG6578; CYP306A1; Cyp306a1-Dm; Cyp306a1; Dmel\\CG6578; Phm; exo; phm; phtm; ptm", "protein_names_uniprotkb": "Cytochrome P450 306a1; 1.14.15.-; CYPCCCVIA1; Dmphm; Protein phantom", "protein_names_refseq": "CG6578-PB; cytochrome P450; exocephalon; phantom, isoform B; phantom; phtm-PB", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hepatocellular adenoma (Disease Ontology:DOID:0050868); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); asbestosis (Disease Ontology:DOID:10320); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); morbid obesity (Disease Ontology:DOID:11981); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); acoustic neuroma (Disease Ontology:DOID:12689); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug-induced hepatitis (Disease Ontology:DOID:2044); colon cancer (Disease Ontology:DOID:219); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); tuberculosis (Disease Ontology:DOID:399); liver disease (Disease Ontology:DOID:409); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); extrinsic allergic alveolitis (Disease Ontology:DOID:841); oral cavity cancer (Disease Ontology:DOID:8618); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); neonatal abstinence syndrome (Disease Ontology:DOID:9828); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dme:Dmel_CG6578); (R-DME-211958); (R-DME-2142816)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15350618;16110336;17322555;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in the metabolism of insect hormones; responsible for ecdysteroid C25-hydroxylase activity. May be involved in the breakdown of synthetic insecticides., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5AC85;A5AC97;A5AC99", "ec_number_list": "1.14.-.-;1.14.14.-;1.14.15.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity;GO:0035302 ecdysteroid 25-hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0008202 steroid metabolic process;GO:0048477 oogenesis;GO:0006082 organic acid metabolic process;GO:0001700 embryonic development via the syncytial blastoderm", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VWR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VWV8-1", "uniprot_id": "NOSIP_DROME", "mass": 34158.0, "length": 307, "protein_name": "Nitric oxide synthase-interacting protein homolog", "gene_name": "CG6179", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_573288", "gene_names_uniprotkb": "CG6179", "gene_names_refseq": "CG6179; Dmel\\CG6179; NOSIPL", "protein_names_uniprotkb": "Nitric oxide synthase-interacting protein homolog", "protein_names_refseq": "CG6179-PA; uncharacterized protein", "tax_id": 7227, "disease": "holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (dme:Dmel_CG6179); (R-DME-203754)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0043086 negative regulation of catalytic activity;GO:0051001 negative regulation of nitric-oxide synthase activity;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VWV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VX09-1", "uniprot_id": "ARP8_DROME", "mass": 67780.0, "length": 607, "protein_name": "Actin-related protein 8", "gene_name": "Arp8", "organism": "Fruit fly", "refseq_name": "Actin-related protein 8", "refseq_ac": "NP_573251", "gene_names_uniprotkb": "Arp8; CG7846", "gene_names_refseq": "Arp8; CG7846; Dmel\\CG7846; arp8; dArp8", "protein_names_uniprotkb": "Actin-related protein 8", "protein_names_refseq": "Actin-related protein 8; Arp8-PA; CG7846-PA; actin related protein 8", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7846); (R-DME-5689603); (R-DME-5696394)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16618800;18327897", "class_list": "", "function": "Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity)., [UniProtKB]; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0031011 Ino80 complex", "go_biological_process": "GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VX09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VX25-1", "uniprot_id": "UBE2S_DROME", "mass": 23337.0, "length": 209, "protein_name": "Ubiquitin-conjugating enzyme E2 S", "gene_name": "Ube2S", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001033852", "gene_names_uniprotkb": "Ube2S; CG8188; Dmel\\CG8188; Dmel_CG8188; Ubc", "gene_names_refseq": "CG8188; Dmel\\CG8188; Ubc; Ube2S", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 S; 2.3.2.23; E2 ubiquitin-conjugating enzyme S; Ubiquitin carrier protein S; Ubiquitin-protein ligase S", "protein_names_refseq": "CG8188-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8188); (R-DME-141430); (R-DME-174048); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-176407); (R-DME-176408); (R-DME-176409); (R-DME-176412); (R-DME-179409); (R-DME-2467813); (R-DME-2559582); (R-DME-68867); (R-DME-69017); (R-DME-8866652); (R-DME-983168)", "pathway_count": 18, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;19822757;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;2.3.2.25;2.3.2.23;2.1.1.356;2.1.1.367;2.1.1.371;2.1.1.355;2.1.1.369;2.1.1.368;2.3.2.31;2.7.11.22;2.7.11.23;2.7.11.21;3.4.19.-;5.6.1.5;6.2.1.64;2.3.2.26;2.7.11.1;2.3.2.-;2.3.2.34;2.3.2.24", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VX25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VXD1-1", "uniprot_id": "SINGL_DROME", "mass": 19460.0, "length": 176, "protein_name": "Protein singles bar", "gene_name": "sing", "organism": "Fruit fly", "refseq_name": "singles bar", "refseq_ac": "NP_573146", "gene_names_uniprotkb": "sing; CG13011", "gene_names_refseq": "CG13011; Dmel\\CG13011; Sing; singles-bar; sing", "protein_names_uniprotkb": "Protein singles bar", "protein_names_refseq": "CG13011-PA; sing-PA; singles bar", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13011)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;17537424;25797154", "class_list": "", "function": "Essential for myoblast fusion in developing embryos and pupae, and consequently is essential for muscle formation in adults (PubMed:17537424, PubMed:25797154). Required for progression past the pre-fusion complex stage of myoblast fusion (PubMed:17537424)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G2J5W8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007517 muscle organ development;GO:0007520 myoblast fusion;GO:0007527 adult somatic muscle development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VXD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VXH6-1", "uniprot_id": "CANC_DROME", "mass": 77448.0, "length": 681, "protein_name": "Calpain-C", "gene_name": "CalpC", "organism": "Fruit fly", "refseq_name": "calpain C", "refseq_ac": "NP_573118", "gene_names_uniprotkb": "CalpC; CG3692", "gene_names_refseq": "CG3692; CalpC; Dmel\\CG3692", "protein_names_uniprotkb": "Calpain-C; CANP C; Calcium-activated neutral proteinase homolog C", "protein_names_refseq": "CG3692-PA; CalpC-PA; calpain C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3692); (R-DME-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;12646209", "class_list": "", "function": "Not known; does not seem to have protease activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86NA1;Q95R89", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VXH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VXN2-1", "uniprot_id": "SUN_DROME", "mass": 6791.0, "length": 61, "protein_name": "Protein stunted", "gene_name": "sun", "organism": "Fruit fly", "refseq_name": "stunted, isoform A", "refseq_ac": "NP_524682", "gene_names_uniprotkb": "sun; CG9032", "gene_names_refseq": "ATP5E; ATPE; ATPsynepsilon; BcDNA:RE19513; BcDNA:RH48911; CG9032; Dmel\\CG9032; Sun; l(1)13Fe; l(1)XV; sun", "protein_names_uniprotkb": "Protein stunted", "protein_names_refseq": "ATP synthase epsilon chain; ATP synthase, epsilon subunit; CG9032-PA; F0/F1 ATP synthase epsilon; stunted, isoform A; stunted; sun-PA", "tax_id": 7227, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 3 (Disease Ontology:DOID:0060332)", "pathway": " (dme:Dmel_CG9032); (R-DME-163210); (R-DME-8949613)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;15133470;19672878", "class_list": "", "function": "Activates the G protein-coupled receptor mth in vitro, leading to increased intracellular calcium ion levels., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IR24", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005615 extracellular space;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VXN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VXV9-1", "uniprot_id": "WCSD_DROME", "mass": 36608.0, "length": 317, "protein_name": "WSCD family member CG9164", "gene_name": "CG9164", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform D", "refseq_ac": "NP_573021", "gene_names_uniprotkb": "CG9164", "gene_names_refseq": "CG9164; Dmel\\CG9164", "protein_names_uniprotkb": "WSCD family member CG9164", "protein_names_refseq": "CG9164-PD; uncharacterized protein, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9164)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18477586", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B4F678;B4F682;B4F683;B4F685", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VXV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VXY9-1", "uniprot_id": "Q9VXY9_DROME", "mass": 27802.0, "length": 242, "protein_name": "Opossum, isoform A; Opossum, isoform C", "gene_name": "opm", "organism": "Fruit fly", "refseq_name": "opossum, isoform A", "refseq_ac": "NP_572994", "gene_names_uniprotkb": "opm; CG9053; Dmel\\CG9053; Dmel_CG9053; Omp; opo; p24", "gene_names_refseq": "CG9053; Dmel\\CG9053; Omp; opm; opo; p24", "protein_names_uniprotkb": "Opossum, isoform A; Opossum, isoform C", "protein_names_refseq": "CG9053-PA; opm-PA; opossum, isoform A; opossum", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9053); (R-DME-3238698)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KV06", "ec_number_list": "", "go_molecular_function": "GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VXY9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYA0-1", "uniprot_id": "NADE_DROME", "mass": 87615.0, "length": 787, "protein_name": "Glutamine-dependent NAD(+) synthetase", "gene_name": "Nadsyn", "organism": "Fruit fly", "refseq_name": "NAD synthetase, isoform C", "refseq_ac": "NP_001285224", "gene_names_uniprotkb": "Nadsyn; CG9940", "gene_names_refseq": "145027_at; CG9940; Dmel\\CG9940; NADSYN; NADS; Nadsyn; Q9VYA0", "protein_names_uniprotkb": "Glutamine-dependent NAD(+) synthetase; 6.3.5.1; NAD(+) synthase [glutamine-hydrolyzing]", "protein_names_refseq": "CG9940-PC; NAD synthetase, isoform C; NAD[+]synthase; Nadsyn-PC", "tax_id": 7227, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (dme:Dmel_CG9940); (R-DME-196807)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;27448710", "class_list": "", "function": "Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (By similarity). Because of its role in energy metabolism, involved in the modulation of aged-related cardiac function, mobility, and lifespan (PubMed:27448710)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4E7;Q8IH17", "ec_number_list": "6.3.5.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity;GO:0004359 glutaminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:1900074 negative regulation of neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VYA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYA7-1", "uniprot_id": "RRP12_DROME", "mass": 153557.0, "length": 1384, "protein_name": "RRP12-like protein", "gene_name": "Dmel\\CG2691", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001285218", "gene_names_uniprotkb": "Dmel\\CG2691; CG2691; Dmel_CG2691; RRP12", "gene_names_refseq": "CG2691; Dmel\\CG2691; RRP12", "protein_names_uniprotkb": "RRP12-like protein", "protein_names_refseq": "CG2691-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2691)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q960Z7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VYA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYQ5-1", "uniprot_id": "CP318_DROME", "mass": 61782.0, "length": 536, "protein_name": "Probable cytochrome P450 318a1", "gene_name": "Cyp318a1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 318a1", "refseq_ac": "NP_727590", "gene_names_uniprotkb": "Cyp318a1; CG1786", "gene_names_refseq": "318a1; CG11364; CG1786; CYP318a1; Cyp318A1; Cyp318a1; Dmel\\CG1786", "protein_names_uniprotkb": "Probable cytochrome P450 318a1; 1.14.-.-; CYPCCCXVIIIA1", "protein_names_refseq": "CG1786-PA; Cyp318a1-PA; cytochrome P450 318a1; cytochrome P450", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1786)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZ48;Q9VYQ6", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VYQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYR0-1", "uniprot_id": "LSM12_DROME", "mass": 23746.0, "length": 217, "protein_name": "LSM12 homolog A", "gene_name": "Lsm12a", "organism": "Fruit fly", "refseq_name": "LSM12 homolog a", "refseq_ac": "NP_572777", "gene_names_uniprotkb": "Lsm12a; CG15735; Lsm12", "gene_names_refseq": "BcDNA:LD05893; CG15735; Dmel\\CG15735; Lsm12a; Lsm12", "protein_names_uniprotkb": "LSM12 homolog A", "protein_names_refseq": "CG15735-PA; LSM12 homolog a; LSM12 homolog; Lsm12a-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15735)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;28388438;30563832", "class_list": "", "function": "Component of the Atx2-tyf activator complex which functions in the circadian pacemaker neurons to activate the TYF-dependent translation of per and maintain 24 hour periodicity in circadian behaviors. Within the Atx2-tyf complex, likely to function as a molecular adapter which stabilizes the interaction between Atx2 and the translational regulator tyf., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0F6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VYR0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYS3-1", "uniprot_id": "RENT1_DROME", "mass": 129913.0, "length": 1180, "protein_name": "Regulator of nonsense transcripts 1 homolog", "gene_name": "Upf1", "organism": "Fruit fly", "refseq_name": "Upf1 RNA helicase, isoform B", "refseq_ac": "NP_001285145", "gene_names_uniprotkb": "Upf1; CG1559; Dm-Upf1; DmUpf1; Dmel\\CG1559; Dmel_CG1559; UPF1; Upf1p; dUPF1; smg-2; upf1", "gene_names_refseq": "CG1559; Dm-Upf1; DmUpf1; Dmel\\CG1559; UPF1; Upf1p; Upf1; dUPF1; smg-2; upf1", "protein_names_uniprotkb": "Regulator of nonsense transcripts 1 homolog; 5.6.2.3; 5.6.2.5; Double-stranded nucleic acid 5'-3' helicase Upf1", "protein_names_refseq": "CG1559-PB; Upf1 RNA helicase, isoform B; Upf1-PB; up-frameshift suppressor 1", "tax_id": 7227, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (dme:Dmel_CG1559); (R-DME-975956); (R-DME-975957)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12881430;16110336;16199763;17178403;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Has ATP-dependent 5'-3' helicase active on RNA:DNA; RNA:RNA and DNA:DNA substrates with a 5'-extension (By similarity). Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95RG9", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.1.-.-;3.1.3.16;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071598 neuronal ribonucleoprotein granule;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:2000624 positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1903313 positive regulation of mRNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VYS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYV3-1", "uniprot_id": "TXND5_DROME", "mass": 46650.0, "length": 416, "protein_name": "Thioredoxin domain-containing protein 5 homolog", "gene_name": "prtp", "organism": "Fruit fly", "refseq_name": "pretaporter, isoform B", "refseq_ac": "NP_001188583", "gene_names_uniprotkb": "prtp; CG1837", "gene_names_refseq": "CG1837; Dmel\\CG1837; Prtp; anon-EST:Posey253; p47; prtp", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 5 homolog; Protein pretaporter", "protein_names_refseq": "CG1837-PB; pret-a-porter; pretaporter, isoform B; pretaporter; prtp-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1837); (R-DME-432720); (R-DME-6798695)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;19927123;22158613;23337816", "class_list": "", "function": "Possesses thioredoxin activity (By similarity). Acts as a ligand for Drpr and is required for the phagocytosis of apoptotic cells (PubMed:19927123, PubMed:23337816). Binds to the extracellular region of Drpr and augments Drpr tyrosine phosphorylation (PubMed:19927123, PubMed:23337816)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PGX2", "ec_number_list": "", "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0012505 endomembrane system", "go_biological_process": "GO:0006457 protein folding;GO:0043277 apoptotic cell clearance;GO:2000427 positive regulation of apoptotic cell clearance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VYV3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYX1-1", "uniprot_id": "ENY2_DROME", "mass": 11474.0, "length": 101, "protein_name": "Enhancer of yellow 2 transcription factor", "gene_name": "e(y)2", "organism": "Fruit fly", "refseq_name": "enhancer of yellow 2", "refseq_ac": "NP_524846", "gene_names_uniprotkb": "e(y)2; CG15191; ENY2", "gene_names_refseq": "CG15191; Dmel\\CG15191; E(y)2; ENY2; LBC; Sus1; dE(y)2; dENY2; de(y)2; e(y)2; e(y)[2]; e(y2)", "protein_names_uniprotkb": "Enhancer of yellow 2 transcription factor", "protein_names_refseq": "CG15191-PA; e(y)2-PA; enhancer of yellow 2; late boundary complex", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15191)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;11438676;12537569;12537572;17643381;18034162;18206972;19947544;20048002;20714859;27016737;30713769", "class_list": "", "function": "Involved in mRNA export coupled transcription activation by association with both the TREX-2/AMEX and the SAGA complexes (PubMed:18034162, PubMed:19947544, PubMed:27016737). The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination (PubMed:11438676, PubMed:18206972). Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B (PubMed:18206972). The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription (PubMed:18034162, PubMed:19947544). Required for nuclear receptor-mediated transactivation (PubMed:20048002, PubMed:20714859). Involved in transcription elongation by recruiting the THO complex onto nascent mRNA (PubMed:20048002). The TREX-2/AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket) (PubMed:27016737). TREX-2/AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:17643381, PubMed:27016737). Recruited to the su(Hw) insulators via its interaction with su(Hw) and participates in the barrier activity of such insulators (PubMed:17643381). In contrast, it does not participate in the enhancer-blocking activity of the su(Hw) insulators (PubMed:17643381)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043035 chromatin insulator sequence binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0001094 TFIID-class transcription factor complex binding;GO:0070742 C2H2 zinc finger domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006406 mRNA export from nucleus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VYX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VYY3-1", "uniprot_id": "UBA5_DROME", "mass": 44167.0, "length": 404, "protein_name": "Ubiquitin-like modifier-activating enzyme 5", "gene_name": "Uba5", "organism": "Fruit fly", "refseq_name": "Ubiquitin-like activating enzyme 5", "refseq_ac": "NP_572722", "gene_names_uniprotkb": "Uba5; CG1749", "gene_names_refseq": "CG1749; Dmel\\CG1749; MoeB; Uba5; dMoaD; dUBA5", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin-activating enzyme 5", "protein_names_refseq": "CG1749-PA; Uba5 homologue; Uba5-PA; Ubiquitin-like activating enzyme 5; ubiquitin activating enzyme 5", "tax_id": 7227, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 44 (Disease Ontology:DOID:0080424); autosomal recessive spinocerebellar ataxia 24 (Disease Ontology:DOID:0111615)", "pathway": " (dme:Dmel_CG1749); (R-DME-983168)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;15952742;18477586;19126864;26872069;37086384", "class_list": "", "function": "E1-like enzyme which activates UFM1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B4F5S5;B4F5S6;B4F5S7;B4F5S8;B4F5S9;B4F5T0;B4F5T1;B4F5T3;C0MLQ2;C0MLQ9;C0MLR0;Q8SYN2", "ec_number_list": "", "go_molecular_function": "GO:0071566 UFM1 activating enzyme activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0050905 neuromuscular process;GO:0071569 protein ufmylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9VYY3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VZN4-1", "uniprot_id": "DAR1_DROME", "mass": 82348.0, "length": 751, "protein_name": "Dendritic arbor reduction protein 1", "gene_name": "dar1", "organism": "Fruit fly", "refseq_name": "dendritic arbor reduction 1", "refseq_ac": "NP_001097493", "gene_names_uniprotkb": "dar1; CG12029", "gene_names_refseq": "CG12029; Dar1; Dmel\\CG12029; dar1; l(3)63Ed; l(3)SH5", "protein_names_uniprotkb": "Dendritic arbor reduction protein 1", "protein_names_refseq": "CG12029-PB; dar1-PB; dendritic arbor reduction 1; lethal (3) 63Ed", "tax_id": 7227, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); intracranial aneurysm (Disease Ontology:DOID:10941); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dme:Dmel_CG12029)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21368042;26490864", "class_list": "", "function": "Transcriptional regulator which promotes dendrite growth by suppressing, either directly or indirectly, the expression of the microtubule-severing protein spas (PubMed:21368042). Determines multipolar neuron morphology in postmitotic neurons by positively regulating the expression of genes involved in nuclear positioning including several dynein genes and the nuclear migration protein nudC (PubMed:26490864)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4V6V6", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VZN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VZS6-1", "uniprot_id": "NSMA_DROME", "mass": 49643.0, "length": 442, "protein_name": "Putative neutral sphingomyelinase", "gene_name": "nSMase", "organism": "Fruit fly", "refseq_name": "neutral sphingomyelinase", "refseq_ac": "NP_647790", "gene_names_uniprotkb": "nSMase; CG12034", "gene_names_refseq": "CG12034; Dmel\\CG12034; nSMase; nsmase", "protein_names_uniprotkb": "Putative neutral sphingomyelinase; 3.1.4.12", "protein_names_refseq": "CG12034-PA; nSMase-PA; neutral sphingomyelinase; neutral-sphingomyelinase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12034); (R-DME-9840310)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q961B4", "ec_number_list": "3.1.4.12", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0004767 sphingomyelin phosphodiesterase activity;GO:0061751 neutral sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0071944 cell periphery;GO:0005901 caveola", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0046513 ceramide biosynthetic process;GO:0006684 sphingomyelin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VZS6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VZU4-1", "uniprot_id": "NDUS3_DROME", "mass": 29971.0, "length": 265, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "gene_name": "ND-30", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase (ubiquinone) 30 kDa subunit", "refseq_ac": "NP_647775", "gene_names_uniprotkb": "ND-30; CG12079; NDUFS3", "gene_names_refseq": "C-I 30; C-I-NDUFS3; C-I30; CG 12079; CG12079; Dmel\\CG12079; ND-30; ND30; NDUFS3; NDufS3; NUGM; dNDUFS3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; 7.1.1.2; NADH dehydrogenase (Ubiquinone) 30 kDa subunit", "protein_names_refseq": "30 kDa subunit of complex-I; CG12079-PA; NADH dehydrogenase (ubiquinone) 30 kDa subunit; NADH dehydrogenase (ubiquinone) Fe-S protein 3; NADH ubiquinone oxidoreductase 30 kDa; NADH-UBIQUINONE OXIDOREDUCTASE 30 KDA SUBUNIT; NADH:ubiquinone oxidoreductase 30 kDa subunit; ND-30-PA; complex I 30 kDa; nuclear-encoded subunit NDUFS3 of complex I", "tax_id": 7227, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); nuclear type mitochondrial complex I deficiency 8 (Disease Ontology:DOID:0112081); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dme:Dmel_CG12079); (R-DME-611105); (R-DME-6799198); (R-DME-9837999)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;23509070;31378462", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.40;1.1.1.38;1.1.1.39;1.2.4.2;2.3.1.37;3.5.3.1;7.1.1.2;2.7.11.2;2.7.11.-;7.1.2.2;1.2.4.1;6.2.1.4;4.98.1.1;1.-.-.-;1.1.1.62;1.1.1.239;1.1.1.37;2.1.1.320;4.2.1.3;3.4.21.92;1.2.1.3;1.8.1.4;1.1.1.41;2.8.3.5;2.3.-.-;2.3.1.-;2.3.1.9;4.2.1.2;2.3.3.16;5.3.3.21", "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0072593 reactive oxygen species metabolic process;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VZU4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VZX1-1", "uniprot_id": "SPZ5_DROME", "mass": 42827.0, "length": 387, "protein_name": "Protein spaetzle 5", "gene_name": "spz5", "organism": "Fruit fly", "refseq_name": "spatzle 5", "refseq_ac": "NP_647753", "gene_names_uniprotkb": "spz5; CG9972; DNT1; NT2", "gene_names_refseq": "CG9972; CT28115; DNT2; Dmel\\CG9972; NT2; Spz-5; Spz5; spz-5; spz5", "protein_names_uniprotkb": "Protein spaetzle 5; Neurotrophic factor 2; Protein spatzle 5", "protein_names_refseq": "CG9972-PA; neurotrophin 2; spatzle 5; spatzle5; spz5-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9972)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;11536362;12537572;19018662;23892553;24124519", "class_list": "", "function": "Neurotrophin which may function as a ligand for the Toll-related receptors Toll-6 and Toll-7 (PubMed:23892553). Binds to Toll-7 and Toll-6, and probably acts as their ligands in the promotion of motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:19018662, PubMed:23892553). Involved in synaptic targeting of ISNb/d motorneurons and also some SNa motorneurons (PubMed:19018662). May be involved in the normal development of specific neurons at the neuromuscular junction (PubMed:24124519)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0048018 receptor ligand activity;GO:0005121 Toll binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0048167 regulation of synaptic plasticity;GO:0043524 negative regulation of neuron apoptotic process;GO:0008063 Toll signaling pathway;GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VZX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9VZZ4-1", "uniprot_id": "PXDN_DROME", "mass": 170514.0, "length": 1527, "protein_name": "Peroxidasin", "gene_name": "Pxn", "organism": "Fruit fly", "refseq_name": "peroxidasin, isoform A", "refseq_ac": "NP_523891", "gene_names_uniprotkb": "Pxn; CG12002", "gene_names_refseq": "CG12002; CT1239; DmPxd-a; Dmel\\CG12002; Dpxn; HPX4; Pxn; pxn", "protein_names_uniprotkb": "Peroxidasin; 1.11.2.-", "protein_names_refseq": "CG12002-PA; Pxn-PA; peroxidasin, isoform A; peroxidasin; peroxydasin; protein X", "tax_id": 7227, "disease": "anterior segment dysgenesis 7 (Disease Ontology:DOID:0080612)", "pathway": " (dme:Dmel_CG12002); (R-DME-209968); (R-DME-6798695); (R-DME-8941413)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17893096;22842973;8062820", "class_list": "", "function": "Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV NC1 hexamer (PubMed:22842973). Plays a role in extracellular matrix consolidation, phagocytosis and defense (PubMed:8062820)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q23991;Q960D1;Q961K8", "ec_number_list": "2.4.1.186;5.4.2.7;5.4.2.-;3.5.2.17;3.2.1.17;3.2.1.31;1.1.1.42;2.4.2.1;2.7.11.24;2.7.1.40;3.5.3.1;4.1.2.13;2.7.4.6;2.4.2.7;3.6.5.-;1.11.1.6;5.3.1.9;2.7.1.11;2.7.11.13;1.1.1.205;3.6.4.12;3.6.4.6;1.16.3.1;2.7.1.35;3.2.1.-;3.4.19.9;3.5.1.26;2.7.1.1;5.2.1.8;3.4.19.-;1.11.1.24;5.6.1.5;5.3.99.3;2.7.10.2;5.4.2.11;5.4.2.4;3.2.1.23;3.6.4.13;3.5.4.5;1.11.1.-;1.6.3.1;6.3.4.21;4.6.1.19;3.2.1.51;4.2.1.24;3.5.4.4;1.11.2.-;2.4.1.25;3.2.1.33;2.7.1.-;2.4.1.1;3.5.4.6;2.3.2.26;1.6.2.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030198 extracellular matrix organization;GO:0006909 phagocytosis;GO:0030199 collagen fibril organization;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VZZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0C7-1", "uniprot_id": "OPI10_DROME", "mass": 21860.0, "length": 197, "protein_name": "Protein OPI10 homolog", "gene_name": "CG13926", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_647633", "gene_names_uniprotkb": "CG13926", "gene_names_refseq": "CG13926; Dmel\\CG13926", "protein_names_uniprotkb": "Protein OPI10 homolog", "protein_names_refseq": "CG13926-PA; uncharacterized protein", "tax_id": 7227, "disease": "hypomyelinating leukodystrophy 13 (Disease Ontology:DOID:0060795)", "pathway": " (dme:Dmel_CG13926); (R-DME-3371453)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030544 Hsp70 protein binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W0C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0K0-1", "uniprot_id": "JIP1_DROME", "mass": 53816.0, "length": 490, "protein_name": "JNK-interacting protein 1", "gene_name": "Aplip1", "organism": "Fruit fly", "refseq_name": "APPL-interacting protein 1, isoform B", "refseq_ac": "NP_728573", "gene_names_uniprotkb": "Aplip1; CG1200; SP512", "gene_names_refseq": "APLIP1; Aplip-1; Aplip1; Aplip; CG1200; Dmel\\CG1200; E(Khc)ek4; EK4; Ek4; JIP-1; JIP1; Jip1/2; Jip1; SP512; aplilp1; aplip1; dp1; ek4; jip1", "protein_names_uniprotkb": "JNK-interacting protein 1; APLIP1; APP-like-interacting protein 1; JIP-1; Protein eye developmental SP512", "protein_names_refseq": "APP-like protein interacting protein 1; APPL-interacting protein 1, isoform B; Aplip1-PB; CG1200-PB; JNK interacting protein-1; c-Jun N-terminal kinase (JNK)-interacting protein", "tax_id": 7227, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG1200)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11912189;12537569;12537572", "class_list": "", "function": "The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGG5;Q9NH69", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019894 kinesin binding;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0030424 axon;GO:1904115 axon cytoplasm", "go_biological_process": "GO:2000331 regulation of terminal button organization;GO:0007254 JNK cascade;GO:0048490 anterograde synaptic vesicle transport;GO:0046328 regulation of JNK cascade;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W0K0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0M1-1", "uniprot_id": "CE290_DROME", "mass": 227962.0, "length": 1978, "protein_name": "Centrosomal protein Cep290", "gene_name": "Cep290", "organism": "Fruit fly", "refseq_name": "centrosomal protein 290kDa, isoform B", "refseq_ac": "NP_001261227", "gene_names_uniprotkb": "Cep290; CG13889", "gene_names_refseq": "CEP290; CG13889; Cep290; Dmel\\CG13889; Q9W0M1_DROME; cep290", "protein_names_uniprotkb": "Centrosomal protein Cep290", "protein_names_refseq": "CG13889-PB; Cep290-PB; centrosomal protein 290kDa, isoform B; cep290", "tax_id": 7227, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Senior-Loken syndrome (Disease Ontology:DOID:0050576); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 4 (Disease Ontology:DOID:0070118); Bardet-Biedl syndrome 14 (Disease Ontology:DOID:0110136); Leber congenital amaurosis 10 (Disease Ontology:DOID:0110291); Joubert syndrome 5 (Disease Ontology:DOID:0111000); Leber congenital amaurosis (Disease Ontology:DOID:14791); cystic kidney disease (Disease Ontology:DOID:2975); kidney disease (Disease Ontology:DOID:557); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG13889); (R-DME-6798695)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;25447994;27577095;27646273;30013109;31821146;33370260", "class_list": "", "function": "Essential for ciliogenesis in sensory neurons and spermatocytes (PubMed:25447994, PubMed:30013109, PubMed:31821146, PubMed:33370260). During neuron and spermatocyte ciliogenesis, essential for initiating transition zone (TZ) assembly and is required for the formation of diverse connections between microtubules and between microtubules and the membrane (PubMed:25447994, PubMed:30013109, PubMed:31821146, PubMed:33370260). Regulates TZ assembly by recruiting DZIP1 to the plasma membrane where it promotes early ciliary membrane formation resulting in the initiation of TZ assembly (PubMed:31821146, PubMed:33370260)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T3H8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0035869 ciliary transition zone;GO:0061822 ciliary cap", "go_biological_process": "GO:0097711 ciliary basal body-plasma membrane docking;GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:1905349 ciliary transition zone assembly;GO:0061824 cytosolic ciliogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9W0M1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0M7-1", "uniprot_id": "SF3B3_DROME", "mass": 136616.0, "length": 1227, "protein_name": "Splicing factor 3B subunit 3", "gene_name": "Sf3b3", "organism": "Fruit fly", "refseq_name": "splicing factor 3b subunit 3, isoform C", "refseq_ac": "NP_001261223", "gene_names_uniprotkb": "Sf3b3; CG13900", "gene_names_refseq": "CG13900; Dmel\\CG13900; SF3B3; Sf3b3", "protein_names_uniprotkb": "Splicing factor 3B subunit 3", "protein_names_refseq": "CG13900-PC; Sf3b3-PC; splicing factor 3b subunit 3, isoform C; splicing factor 3b subunit 3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13900); (R-DME-72163); (R-DME-72165); (R-DME-9770562); (R-DME-9943411)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;12537572;18981222;27185460", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:18981222). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:18981222). Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). May also be involved in the assembly of the 'E' complex (By similarity). Also belongs to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PDJ8;Q5BI86", "ec_number_list": "", "go_molecular_function": "GO:0030620 U2 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome;GO:0000124 SAGA complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W0M7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0R6-1", "uniprot_id": "MTH9_DROME", "mass": 59039.0, "length": 513, "protein_name": "Probable G protein-coupled receptor Mth-like 9", "gene_name": "mthl9", "organism": "Fruit fly", "refseq_name": "methuselah-like 9", "refseq_ac": "NP_612029", "gene_names_uniprotkb": "mthl9; CG17084", "gene_names_refseq": "CG17084; Dmel\\CG17084; Mth-9; Mthl9; anon-WO0170980.163; anon-WO0170980.164; mthl9", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 9; Protein methuselah-like 9", "protein_names_refseq": "CG17084-PA; Methuselah-9; methuselah-like 9; mth-like 9; mthl9-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17084)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10908591;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W0R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W0S8-1", "uniprot_id": "WAGC_DROME", "mass": 19053.0, "length": 163, "protein_name": "Augmin complex subunit wac", "gene_name": "wac", "organism": "Fruit fly", "refseq_name": "wee augmin, isoform C", "refseq_ac": "NP_001163306", "gene_names_uniprotkb": "wac; CG13879; dgt8", "gene_names_refseq": "CG13879; Dgt8; Dmel\\CG13879; Wac; wac; was", "protein_names_uniprotkb": "Augmin complex subunit wac; wee Augmin component", "protein_names_refseq": "CG13879-PC; augmin; wac-PC; wee augmin, isoform C; wee-augmin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13879)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;19289792;19369198;23785300;24829288", "class_list": "", "function": "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules (PubMed:19289792). The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules (PubMed:19289792). wac is dispensable for somatic mitosis and for assembly of spindle microtubules in oocytes during female meiosis but is required during female meiosis for chromosome alignment and segregation (PubMed:19289792). It is required for microtubule assembly near spindle poles in oocytes (PubMed:23785300). It is also required for acentrosomal microtubule nucleation and meiotic spindle formation during male meiosis (PubMed:24829288). wac binds to microtubules in vitro (PubMed:19289792)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JHV2", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005819 spindle;GO:0005874 microtubule;GO:0072687 meiotic spindle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007143 female meiotic nuclear division;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9W0S8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W141-1", "uniprot_id": "ATPK_DROME", "mass": 12483.0, "length": 107, "protein_name": "Putative ATP synthase subunit f, mitochondrial", "gene_name": "ATPsynF", "organism": "Fruit fly", "refseq_name": "ATP synthase, subunit F, isoform B", "refseq_ac": "NP_611940", "gene_names_uniprotkb": "ATPsynF; CG4692", "gene_names_refseq": "ATPK; ATPsynF; CG4692; Dmel\\CG4692; anon-EST:Posey45", "protein_names_uniprotkb": "Putative ATP synthase subunit f, mitochondrial", "protein_names_refseq": "ATP synthase f chain; ATP synthase, subunit F, isoform B; ATP synthase; ATPsynF-PB; CG4692-PB; F0/F1 ATP synthase F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4692); (R-DME-163210); (R-DME-8949613)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4VCL5;Q0E8W4;Q1ECC6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W141-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W157-1", "uniprot_id": "BRCA2_DROME", "mass": 108649.0, "length": 971, "protein_name": "Breast cancer type 2 susceptibility protein homolog", "gene_name": "Brca2", "organism": "Fruit fly", "refseq_name": "BRCA2, DNA repair associated", "refseq_ac": "NP_611925", "gene_names_uniprotkb": "Brca2; CG30169", "gene_names_refseq": "30169; BRCA2; BcDNA:SD25109; Brca2; CG13583; CG13584; CG30169; Dmbrca2; Dmel\\CG30169; brca2; brca; dmbrca2", "protein_names_uniprotkb": "Breast cancer type 2 susceptibility protein homolog; dmbrca2", "protein_names_refseq": "BRCA2, DNA repair associated; Brca2-PA; CG30169-PA; breast cancer 2 early onset homolog; breast cancer 2, early onset homolog", "tax_id": 7227, "disease": "46 XX gonadal dysgenesis (Disease Ontology:DOID:14450)", "pathway": " (dme:Dmel_CG30169)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;17822964;18266476;19501158;22976300", "class_list": "", "function": "Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2CPK7;B2CPK8;Q494G5;Q8MRU0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0006281 DNA repair;GO:0051301 cell division;GO:1901563 response to camptothecin;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9W157-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W1F4-1", "uniprot_id": "THOC5_DROME", "mass": 70889.0, "length": 616, "protein_name": "THO complex subunit 5", "gene_name": "thoc5", "organism": "Fruit fly", "refseq_name": "thoc5", "refseq_ac": "NP_611856", "gene_names_uniprotkb": "thoc5; CG2980", "gene_names_refseq": "CG2980; Dmel\\CG2980; THOC5; Thoc5; garm; thoc5", "protein_names_uniprotkb": "THO complex subunit 5", "protein_names_refseq": "CG2980-PA; garmcho; thoc5-PA; thoc5", "tax_id": 7227, "disease": "breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (dme:Dmel_CG2980); (R-DME-159236)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;15133499;18327897;28472469;30713769", "class_list": "", "function": "The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RL0", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing;GO:0031990 mRNA export from nucleus in response to heat stress", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9W1F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W1P7-1", "uniprot_id": "OR59C_DROME", "mass": 47474.0, "length": 411, "protein_name": "Putative odorant receptor 59c", "gene_name": "Or59c", "organism": "Fruit fly", "refseq_name": "odorant receptor 59c", "refseq_ac": "NP_523823", "gene_names_uniprotkb": "Or59c; CG17226", "gene_names_refseq": "59E.2; 59c; CG17226; DOR120; Dmel\\CG17226; Or59c", "protein_names_uniprotkb": "Putative odorant receptor 59c", "protein_names_refseq": "CG17226-PA; Or59c-PA; odorant receptor 59c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17226)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;10943836;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W1P7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W1P8-1", "uniprot_id": "OR59B_DROME", "mass": 46164.0, "length": 398, "protein_name": "Odorant receptor 59b", "gene_name": "Or59b", "organism": "Fruit fly", "refseq_name": "odorant receptor 59b", "refseq_ac": "NP_523822", "gene_names_uniprotkb": "Or59b; CG3569", "gene_names_refseq": "59E.1; 59b; CG3569; DOR119; DmOR59B; DmOr59b; Dmel\\CG3569; OR59b; Or59B; Or59b", "protein_names_uniprotkb": "Odorant receptor 59b", "protein_names_refseq": "CG3569-PA; Or59b-PA; odorant receptor 59b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3569)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10943836;12537572;16615896;20730480;21937991", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Also plays a role in the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9W1P8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W1U5-1", "uniprot_id": "GR59C_DROME", "mass": 46164.0, "length": 397, "protein_name": "Putative gustatory receptor 59c", "gene_name": "Gr59c", "organism": "Fruit fly", "refseq_name": "gustatory receptor 59c", "refseq_ac": "NP_726292", "gene_names_uniprotkb": "Gr59c; CG30186; GR59D.2", "gene_names_refseq": "59D.2; 59D2; CG13543; CG30186; Dmel\\CG30186; GR59D.2; GR59c; Gr59D2; Gr59c", "protein_names_uniprotkb": "Putative gustatory receptor 59c", "protein_names_refseq": "CG30186-PA; Gr59c-PA; gustatory receptor 59D.2; gustatory receptor 59c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30186)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10710312;10731132;11516643;12537572;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity;GO:0170022 ionotropic bitter taste receptor activity;GO:0170023 ionotropic sweet taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste;GO:0050913 sensory perception of bitter taste;GO:0050916 sensory perception of sweet taste", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W1U5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W1U6-1", "uniprot_id": "RL372_DROME", "mass": 10195.0, "length": 89, "protein_name": "Large ribosomal subunit protein L37-2", "gene_name": "RpL37-2", "organism": "Fruit fly", "refseq_name": "ribosomal protein L37-2", "refseq_ac": "NP_611757", "gene_names_uniprotkb": "RpL37-2; CG9873; RpL37b", "gene_names_refseq": "CG9873; Dmel\\CG9873; RpL37-2; RpL37b; Rpl37b", "protein_names_uniprotkb": "Large ribosomal subunit protein L37-2; Large ribosomal subunit protein eL37B; Probable 60S ribosomal protein L37-B", "protein_names_refseq": "CG9873-PA; RpL37-2-PA; ribosomal protein L37-2; ribosomal protein L37b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9873)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Binds to the 23S rRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJ24;Q4V3Z3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W1U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W221-1", "uniprot_id": "Q9W221_DROME", "mass": 14086.0, "length": 129, "protein_name": "LITAF domain-containing protein", "gene_name": "Dmel\\CG13510", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": "NP_001246465", "gene_names_uniprotkb": "Dmel\\CG13510; CG13510; Dmel_CG13510", "gene_names_refseq": "CG13510; Dmel\\CG13510", "protein_names_uniprotkb": "LITAF domain-containing protein", "protein_names_refseq": "CG13510-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "Charcot-Marie-Tooth disease type 1C (Disease Ontology:DOID:0110151)", "pathway": " (dme:Dmel_CG13510)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0009631 cold acclimation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W221-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W266-1", "uniprot_id": "WDP_DROME", "mass": 74711.0, "length": 677, "protein_name": "Protein windpipe", "gene_name": "wdp", "organism": "Fruit fly", "refseq_name": "windpipe, isoform E", "refseq_ac": "NP_001286712", "gene_names_uniprotkb": "wdp; CG3413", "gene_names_refseq": "CG30504; CG3413; CT11415; CT39092; Dmel\\CG3413; Wdp; wdp", "protein_names_uniprotkb": "Protein windpipe", "protein_names_refseq": "CG3413-PE; connectin-like; wdp-PE; windpipe, isoform E; windpipe", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3413)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11804792;12537569;12537572;25923769", "class_list": "", "function": "Plays a role in negative regulation of the JAK/STAT pathway by binding to the receptor dome and promoting its internalization for subsequent lysosomal degradation, thereby reducing JAK/STAT signaling., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "E1NZE9;Q8IGN2;Q95U72", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:2000647 negative regulation of stem cell proliferation;GO:0001894 tissue homeostasis;GO:0045807 positive regulation of endocytosis;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT;GO:0060438 trachea development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W266-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2C3-1", "uniprot_id": "ASPG2_DROME", "mass": 43682.0, "length": 397, "protein_name": "L-asparaginase-like protein CG4372", "gene_name": "CG4372", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_611615", "gene_names_uniprotkb": "CG4372", "gene_names_refseq": "CG4372; Dmel\\CG4372", "protein_names_uniprotkb": "L-asparaginase-like protein CG4372", "protein_names_refseq": "CG4372-PA; uncharacterized protein", "tax_id": 7227, "disease": "aspartylglucosaminuria (Disease Ontology:DOID:0050461); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (dme:Dmel_CG4372)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W2C3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2D9-1", "uniprot_id": "EIF3K_DROME", "mass": 25666.0, "length": 222, "protein_name": "Eukaryotic translation initiation factor 3 subunit K", "gene_name": "eIF3k", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 3 subunit k", "refseq_ac": "NP_611604", "gene_names_uniprotkb": "eIF3k; CG10306", "gene_names_refseq": "CG10306; Dmel\\CG10306; eIF3k", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit K; eIF-3 p25; eIF3k", "protein_names_refseq": "CG10306-PA; eIF3k-PA; eukaryotic translation initiation factor 3 subunit k", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10306); (R-DME-156827); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W2D9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2N0-1", "uniprot_id": "CAPZA_DROME", "mass": 32759.0, "length": 286, "protein_name": "F-actin-capping protein subunit alpha", "gene_name": "cpa", "organism": "Fruit fly", "refseq_name": "capping protein alpha", "refseq_ac": "NP_611539", "gene_names_uniprotkb": "cpa; CG10540", "gene_names_refseq": "CG10540; Cap1; CapZalpha; Cp&abg; CpA; Cpa; Dmel\\CG10540; cpalpha; cpa; miro; scrd", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha", "protein_names_refseq": "CG10540-PA; actin capping protein; actin-capping protein; capping alpha; capping protein A; capping protein alpha; capping proteinalpha; capping protein; cpa-PA", "tax_id": 7227, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (dme:Dmel_CG10540)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0016324 apical plasma membrane;GO:0008290 F-actin capping protein complex;GO:0030018 Z disc;GO:0030863 cortical cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0007018 microtubule-based movement;GO:0046329 negative regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W2N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2S3-1", "uniprot_id": "BTBD9_DROME", "mass": 82036.0, "length": 722, "protein_name": "BTB/POZ domain-containing protein 9", "gene_name": "BTBD9", "organism": "Fruit fly", "refseq_name": "BTB (POZ) domain containing 9, isoform B", "refseq_ac": "NP_001259431", "gene_names_uniprotkb": "BTBD9; CG1826", "gene_names_refseq": "BTBD9; CG1826; Dmel\\CG1826; dBTBD9", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 9", "protein_names_refseq": "BTB (POZ) domain containing 9 ortholog; BTB (POZ) domain containing 9, isoform B; BTBD9-PB; CG1826-PB", "tax_id": 7227, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425)", "pathway": " (dme:Dmel_CG1826)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;22658601", "class_list": "", "function": "Essential for the homeostatic regulation of sleep and motor activity, by depressing hyperactivity and wakefulness. May function, at least in part, by ensuring dopamine biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0032225 regulation of synaptic transmission, dopaminergic;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep;GO:0050804 modulation of chemical synaptic transmission;GO:0048512 circadian behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W2S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W2X7-1", "uniprot_id": "YPL1_DROME", "mass": 12923.0, "length": 114, "protein_name": "Protein yippee-like", "gene_name": "Ypel", "organism": "Fruit fly", "refseq_name": "Yippee-like, isoform B", "refseq_ac": "NP_001096936", "gene_names_uniprotkb": "Ypel; CG15309; Ypel3", "gene_names_refseq": "BcDNA:GH10478; CG15309; Dmel\\CG15309; Ypel2; Ypel; dYPEL3", "protein_names_uniprotkb": "Protein yippee-like; Protein yippee-like 3", "protein_names_refseq": "CG15309-PB; Yippee-like, isoform B; Ypel-PB", "tax_id": 7227, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (dme:Dmel_CG15309)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;32461240", "class_list": "", "function": "Involved in regulating synaptic transmission in presynaptic neurons (PubMed:32461240). In class IV dendritic arborization neurons (nociceptors), involved in regulating activation of their second-order neurons (SONs) and maintaining synaptic contact between nociceptors and their SONs (PubMed:32461240)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JUP6", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W2X7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W358-1", "uniprot_id": "RIC8_DROME", "mass": 65602.0, "length": 573, "protein_name": "Chaperone Ric-8", "gene_name": "ric8a", "organism": "Fruit fly", "refseq_name": "ric8a, isoform B", "refseq_ac": "NP_001285048", "gene_names_uniprotkb": "ric8a; CG15797; DmRic8; Dmel\\CG15797; Dmel_CG15797; RIC-8; Ric-8A; Ric-8; Ric8a; Ric8; l(1)G0397; ric-8a; ric-8", "gene_names_refseq": "CG15797; DmRic8; Dmel\\CG15797; RIC-8; Ric-8A; Ric-8; Ric8a; l(1)G0397; ric-8a; ric-8; ric8a", "protein_names_uniprotkb": "Chaperone Ric-8; Synembryn", "protein_names_refseq": "CG15797-PB; ric8a, isoform B; ric8a-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15797)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16228010;16228011;16228012;17569856;17569867;18327897;25074811;25589440;26109356;26109357", "class_list": "", "function": "Chaperone that specifically binds and folds some, but not all, nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity (PubMed:16228010, PubMed:16228011). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G protein-coupled receptors (PubMed:16228012). Required during gastrulation and sensory organ precursor (SOP) formation (PubMed:16228011). Plays a role in positively regulating synapse number and neurotransmitter release (PubMed:25074811)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0061176 type Ib terminal bouton;GO:0061177 type Is terminal bouton", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0050821 protein stabilization;GO:0008104 intracellular protein localization;GO:0007269 neurotransmitter secretion;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9W358-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3C0-1", "uniprot_id": "UTP11_DROME", "mass": 28539.0, "length": 237, "protein_name": "Probable U3 small nucleolar RNA-associated protein 11", "gene_name": "CG1789", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572504", "gene_names_uniprotkb": "CG1789", "gene_names_refseq": "CG1789; Dmel\\CG1789", "protein_names_uniprotkb": "Probable U3 small nucleolar RNA-associated protein 11; U3 snoRNA-associated protein 11", "protein_names_refseq": "CG1789-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1789); (R-DME-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006412 translation;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W3C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3C1-1", "uniprot_id": "NAT10_DROME", "mass": 112874.0, "length": 1008, "protein_name": "RNA cytidine acetyltransferase", "gene_name": "l(1)G0020", "organism": "Fruit fly", "refseq_name": "lethal (1) G0020, isoform A", "refseq_ac": "NP_572503", "gene_names_uniprotkb": "l(1)G0020; CG1994; Dmel\\CG1994; Dmel_CG1994; NAT10; p110", "gene_names_refseq": "CG1994; Dmel\\CG1994; NAT10; l(1)G0020; p110", "protein_names_uniprotkb": "RNA cytidine acetyltransferase; 18S rRNA cytosine acetyltransferase; 2.3.1.-; Polycomb protein l(1)G0020; p110", "protein_names_refseq": "CG1994-PA; l(1)G0020-PA; lethal (1) G0020, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1994)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;11493925;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation., [UniProtKB, HAMAP, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NR51", "ec_number_list": "2.3.1.-", "go_molecular_function": "GO:0051392 tRNA cytidine N4-acetyltransferase activity;GO:1990883 18S rRNA cytidine N-acetyltransferase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0051391 tRNA acetylation;GO:1904812 rRNA acetylation involved in maturation of SSU-rRNA;GO:0006351 DNA-templated transcription;GO:0002101 tRNA wobble cytosine modification;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9W3C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3D3-1", "uniprot_id": "CRAG_DROME", "mass": 187010.0, "length": 1671, "protein_name": "DENN domain-containing protein Crag", "gene_name": "Crag", "organism": "Fruit fly", "refseq_name": "Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform D", "refseq_ac": "NP_001162710", "gene_names_uniprotkb": "Crag; CG12737", "gene_names_refseq": "CG12737; CJ; CRAG; Crag; Dmel\\CG12737; crag", "protein_names_uniprotkb": "DENN domain-containing protein Crag; Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein", "protein_names_refseq": "CG12737-PD; Calmodulin-binding protein related to a Rab3 GDP-GTP exchange protein; Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform D; Crag-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12737); (R-DME-8876198)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;18331716;23226104;23369713;24828534;28228250;9813038", "class_list": "", "function": "Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11 (PubMed:23226104, PubMed:23369713, PubMed:9813038). Essential for maintenance of adult photoreceptor cells (PubMed:23226104). Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport (PubMed:23226104). During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells (PubMed:18331716, PubMed:23369713, PubMed:24828534). Functions by targeting Rab10 to the basal cytoplasm, where it restricts the secretion of BM proteins such as trol/Pcan and vkg/Coll IV to the basal surface (PubMed:18331716, PubMed:23369713, PubMed:24828534). Appears to be involved in regulating the levels and distribution of the guanine nucleotide exchange factor strat, however the two proteins appear to have independent roles in regulating polarized BM protein secretion in the FE (PubMed:28228250)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O96957;Q8T3K8;Q9W3D2", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0045179 apical cortex;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0050829 defense response to Gram-negative bacterium;GO:0042998 positive regulation of Golgi to plasma membrane protein transport;GO:0045089 positive regulation of innate immune response;GO:0070831 basement membrane assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9W3D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3F7-1", "uniprot_id": "MIGA_DROME", "mass": 59024.0, "length": 525, "protein_name": "Mitoguardin", "gene_name": "Miga", "organism": "Fruit fly", "refseq_name": "mitoguardin, isoform B", "refseq_ac": "NP_001162702", "gene_names_uniprotkb": "Miga; CG12125", "gene_names_refseq": "CG12125; Dmel\\CG12125; Miga; miga", "protein_names_uniprotkb": "Mitoguardin", "protein_names_refseq": "CG12125-PB; Miga-PB; mitoguardin, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12125); (R-DME-1483166)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;26711011", "class_list": "", "function": "Regulator of mitochondrial fusion required to maintain neuronal homeostasis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95S64", "ec_number_list": "", "go_molecular_function": "GO:0141038 phosphatidylinositol 3-kinase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0016239 positive regulation of macroautophagy;GO:0007005 mitochondrion organization;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W3F7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3I5-1", "uniprot_id": "OR7A_DROME", "mass": 47650.0, "length": 413, "protein_name": "Odorant receptor 7a", "gene_name": "Or7a", "organism": "Fruit fly", "refseq_name": "odorant receptor 7a", "refseq_ac": "NP_511081", "gene_names_uniprotkb": "Or7a; CG10759", "gene_names_refseq": "7D.1; 7a; CG10759; DOR30; DmOR7a; DmelOr7a; Dmel\\CG10759; OR7a; Or7A; Or7a", "protein_names_uniprotkb": "Odorant receptor 7a", "protein_names_refseq": "CG10759-PA; Or7a-PA; odorant receptor 7a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10759)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;10943836;12537572;16615896;18499458;20439725;21613503", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Highly sensitive to the sex pheromone of the silkworm moth, bombykol. Intriguingly, the fruit fly detectors are more sensitive than the receptors of the silkworm moth, although its ecological significance is unknown. Also responds to pyrazines., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0099604 ligand-gated calcium channel activity;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9W3I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3J5-1", "uniprot_id": "SYFA_DROME", "mass": 55684.0, "length": 498, "protein_name": "Phenylalanine--tRNA ligase alpha subunit", "gene_name": "alpha-PheRS", "organism": "Fruit fly", "refseq_name": "Phenylalanyl-tRNA synthetase, alpha-subunit", "refseq_ac": "NP_572448", "gene_names_uniprotkb": "alpha-PheRS; CG2263", "gene_names_refseq": "CG2263; Dmel\\CG2263; alpha-PheRS", "protein_names_uniprotkb": "Phenylalanine--tRNA ligase alpha subunit; 6.1.1.20; PheRS; Phenylalanyl-tRNA synthetase alpha subunit", "protein_names_refseq": "CG2263-PA; Phenylalanyl-tRNA synthetase alpha subunit; Phenylalanyl-tRNA synthetase, alpha-subunit; alpha-PheRS-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2263)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;25427601", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.20", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004826 phenylalanine-tRNA ligase activity", "go_cellular_component": "GO:0009328 phenylalanine-tRNA ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006432 phenylalanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W3J5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3M2-1", "uniprot_id": "DM7B_DROME", "mass": 64209.0, "length": 571, "protein_name": "DM7 family protein CG15332", "gene_name": "CG15332", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572429", "gene_names_uniprotkb": "CG15332", "gene_names_refseq": "CG15332; Dmel\\CG15332", "protein_names_uniprotkb": "DM7 family protein CG15332", "protein_names_refseq": "CG15332-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15332)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7KVT7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W3M2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3R7-1", "uniprot_id": "ATG5_DROME", "mass": 31468.0, "length": 269, "protein_name": "Autophagy protein 5", "gene_name": "Atg5", "organism": "Fruit fly", "refseq_name": "Autophagy-related 5", "refseq_ac": "NP_572390", "gene_names_uniprotkb": "Atg5; CG1643", "gene_names_refseq": "ATG5; Atg-5; Atg5; CG1643; DmAtg5; Dmel\\CG1643; atg5; dAtg5", "protein_names_uniprotkb": "Autophagy protein 5; APG5-like", "protein_names_refseq": "Atg5-PA; Autophagy-related 5; CG1643-PA; autophagy-specific gene 5", "tax_id": 7227, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 25 (Disease Ontology:DOID:0080259); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); ischemia (Disease Ontology:DOID:326)", "pathway": " (dme:Dmel_CG1643); (R-DME-1632852)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15296714", "class_list": "", "function": "Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3-like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0034274 Atg12-Atg5-Atg16 complex;GO:0061908 phagophore", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W3R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3T5-1", "uniprot_id": "UQCC5_DROME", "mass": 9308.0, "length": 79, "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 5", "gene_name": "sloth1", "organism": "Fruit fly", "refseq_name": "sloth 1, isoform A", "refseq_ac": "NP_727152", "gene_names_uniprotkb": "sloth1; CG32736", "gene_names_refseq": "BcDNA:RE60462; CG14429; CG32736; Dmel\\CG32736; Sloth1; sloth1", "protein_names_uniprotkb": "Ubiquinol-cytochrome c reductase complex assembly factor 5; SMIM4; Small integral membrane protein 4; UQCC5", "protein_names_refseq": "CG32736-PA; sloth 1, isoform A; sloth1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32736)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;36346220", "class_list": "", "function": "Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W3T5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3Y0-1", "uniprot_id": "ZN593_DROME", "mass": 18923.0, "length": 162, "protein_name": "Zinc finger protein 593 homolog", "gene_name": "CG3224", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572335", "gene_names_uniprotkb": "CG3224", "gene_names_refseq": "CG3224; Dmel\\CG3224", "protein_names_uniprotkb": "Zinc finger protein 593 homolog", "protein_names_refseq": "CG3224-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3224)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043021 ribonucleoprotein complex binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W3Y0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3Y5-1", "uniprot_id": "Y4443_DROME", "mass": 83089.0, "length": 736, "protein_name": "Putative ATP-dependent RNA helicase CG14443", "gene_name": "CG14443", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_572330", "gene_names_uniprotkb": "CG14443", "gene_names_refseq": "CG14443; Dmel\\CG14443; cg14443", "protein_names_uniprotkb": "Putative ATP-dependent RNA helicase CG14443; 3.6.4.13", "protein_names_refseq": "CG14443-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14443)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Probable ATP-binding RNA helicase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.13;7.2.2.-;3.6.4.-;3.6.4.10;3.6.4.6;3.6.4.12;5.6.2.4;5.6.2.5;2.7.4.3;5.6.2.3;3.1.-.-;3.6.1.15;3.-.-.-;5.6.1.1;2.7.11.1;3.6.-.-;5.6.2.-", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0010468 regulation of gene expression;GO:0000380 alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W3Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W3Z3-1", "uniprot_id": "AGT_DROME", "mass": 43800.0, "length": 394, "protein_name": "Alanine--glyoxylate aminotransferase", "gene_name": "Agxt", "organism": "Fruit fly", "refseq_name": "Alanine-glyoxylate aminotransferase", "refseq_ac": "NP_511062", "gene_names_uniprotkb": "Agxt; CG3926; Spat", "gene_names_refseq": "AGXT; Agxt; CG3926; Dm-Spat; Dmel\\CG3926; Spat; dAGXT; dAgxt; spat; spa", "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase; 2.6.1.44; AGT", "protein_names_refseq": "Agxt-PA; Alanine-glyoxylate aminotransferase; CG3926-PA; serine pyruvate aminotransferase", "tax_id": 7227, "disease": "primary hyperoxaluria type 1 (Disease Ontology:DOID:0111670); primary hyperoxaluria (Disease Ontology:DOID:2977)", "pathway": " (dme:Dmel_CG3926); (R-DME-389661); (R-DME-9033241)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12220660;12537569;12537572;29980178", "class_list": "", "function": "Catalyzes the pyridoxal 5'-phosphate-dependent transamination of alanine with glyoxylate as an amino group acceptor (PubMed:12220660). Can also catalyze, although with much less efficiency, the transamination of amino-butyrate, phenylalanine and serine with glyoxylate or pyruvate as an amino group acceptor (PubMed:12220660). Does not catalyze the transamination of both 3-hydroxykynurenine and L-kynurenine (PubMed:12220660). May play a role in the detoxification of glyoxylate, a toxic plant metabolite from the fly diet (PubMed:12220660)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C6TP18;Q8T0J1", "ec_number_list": "2.3.1.42;1.1.3.15;1.1.1.42;6.2.1.3;1.11.1.6;3.4.24.56;1.14.13.39;1.3.3.6;2.3.-.-;2.3.1.137;2.3.1.7;5.1.99.4;2.3.1.176;2.3.1.16;2.3.1.155;4.1.3.4;1.4.3.3;1.-.-.-;1.1.1.184;2.3.2.27;5.3.3.8;3.4.21.-;2.6.1.44;5.3.3.21", "go_molecular_function": "GO:0004760 L-serine-pyruvate transaminase activity;GO:0008453 alanine-glyoxylate transaminase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0009436 glyoxylate catabolic process;GO:0019265 glycine biosynthetic process, by transamination of glyoxylate", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W3Z3-1", "record_type": "protein" } ]