[ { "uniprot_canonical_ac": "A0A8V0ZTS2-1", "uniprot_id": "A0A8V0ZTS2_CHICK", "mass": 97381.0, "length": 877, "protein_name": "Potassium voltage-gated channel subfamily Q member 2", "gene_name": "KCNQ2", "organism": "Chicken", "refseq_name": "potassium voltage-gated channel subfamily KQT member 2 isoform X10", "refseq_ac": "XP_004947155", "gene_names_uniprotkb": "KCNQ2", "gene_names_refseq": "KCNQ2", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily Q member 2", "protein_names_refseq": "potassium voltage-gated channel subfamily KQT member 2 isoform X10", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1296072)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052551.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004947155.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030506 ankyrin binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex;GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTS2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTS5-1", "uniprot_id": "A0A8V0ZTS5_CHICK", "mass": 45509.0, "length": 407, "protein_name": "Dynactin subunit 2", "gene_name": "DCTN2", "organism": "Chicken", "refseq_name": "dynactin subunit 2 isoform X1", "refseq_ac": "XP_025001044", "gene_names_uniprotkb": "DCTN2", "gene_names_refseq": "DCTN2; P50", "protein_names_uniprotkb": "Dynactin subunit 2", "protein_names_refseq": "dynactin subunit 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:395587); (R-GGA-2565942); (R-GGA-3371497); (R-GGA-380259); (R-GGA-380270); (R-GGA-380284); (R-GGA-380320); (R-GGA-5620912); (R-GGA-6807878); (R-GGA-6811436); (R-GGA-8854518)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052565.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030426 growth cone;GO:0031982 vesicle;GO:0005869 dynactin complex", "go_biological_process": "GO:0007080 mitotic metaphase chromosome alignment;GO:0007052 mitotic spindle organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTS5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTT4-1", "uniprot_id": "A0A8V0ZTT4_CHICK", "mass": 68425.0, "length": 606, "protein_name": "26S proteasome non-ATPase regulatory subunit 3", "gene_name": "PSMD3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PSMD3", "gene_names_refseq": "", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1169091); (R-GGA-1234176); (R-GGA-1236978); (R-GGA-174084); (R-GGA-174154); (R-GGA-174178); (R-GGA-174184); (R-GGA-187577); (R-GGA-195253); (R-GGA-202424); (R-GGA-2467813); (R-GGA-2871837); (R-GGA-349425); (R-GGA-350562); (R-GGA-382556); (R-GGA-450408); (R-GGA-4608870); (R-GGA-4641257); (R-GGA-4641258); (R-GGA-5358346); (R-GGA-5607764); (R-GGA-5610780); (R-GGA-5610785); (R-GGA-5632684); (R-GGA-5658442); (R-GGA-5668541); (R-GGA-5687128); (R-GGA-5689603); (R-GGA-5689880); (R-GGA-6798695); (R-GGA-68867); (R-GGA-68949); (R-GGA-69017); (R-GGA-69601); (R-GGA-75815); (R-GGA-8854050); (R-GGA-8939236); (R-GGA-8939902); (R-GGA-8941858); (R-GGA-8948751); (R-GGA-8951664); (R-GGA-9020702); (R-GGA-9755511); (R-GGA-9762114); (R-GGA-9766229); (R-GGA-983168); (R-GGA-9907900); (R-GGA-9929356); (R-GGA-9929491); (R-GGA-9931269); (R-GGA-9932298); (R-GGA-9954709)", "pathway_count": 52, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0000502 proteasome complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTT4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTT9-1", "uniprot_id": "A0A8V0ZTT9_CHICK", "mass": 42248.0, "length": 379, "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PRKAG1", "gene_names_refseq": "", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit gamma-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1632852); (R-GGA-380972); (R-GGA-5628897); (R-GGA-9931269)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0016208 AMP binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0006633 fatty acid biosynthetic process;GO:0042149 cellular response to glucose starvation;GO:0045722 positive regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTT9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTU2-1", "uniprot_id": "A0A8V0ZTU2_CHICK", "mass": 109971.0, "length": 1002, "protein_name": "Eukaryotic translation initiation factor 4E nuclear import factor 1", "gene_name": "EIF4ENIF1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EIF4ENIF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E nuclear import factor 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:416961)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019900 kinase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0048255 mRNA stabilization;GO:0017148 negative regulation of translation;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0033962 P-body assembly;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTU3-1", "uniprot_id": "A0A8V0ZTU3_CHICK", "mass": 24512.0, "length": 218, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, 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"missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTU5-1", "uniprot_id": "A0A8V0ZTU5_CHICK", "mass": 147085.0, "length": 1296, "protein_name": "Pleckstrin homology domain-containing family A member 7", "gene_name": "PLEKHA7", "organism": "Chicken", "refseq_name": "pleckstrin homology domain-containing family A member 7 isoform X4", "refseq_ac": "XP_015142122", "gene_names_uniprotkb": "PLEKHA7", "gene_names_refseq": "PLEKHA7", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 7", "protein_names_refseq": "pleckstrin homology domain-containing family A member 7 isoform X4", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0046930 pore complex;GO:0005915 zonula adherens", "go_biological_process": "GO:0046931 pore complex assembly;GO:0044331 cell-cell adhesion mediated by cadherin;GO:0045218 zonula adherens maintenance;GO:0090136 epithelial cell-cell adhesion;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTU5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTV5-1", "uniprot_id": "A0A8V0ZTV5_CHICK", "mass": 19303.0, "length": 181, "protein_name": "Pancreatic progenitor cell differentiation and proliferation factor", "gene_name": "PPDPF", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PPDPF", "gene_names_refseq": "", "protein_names_uniprotkb": "Pancreatic progenitor cell differentiation and proliferation factor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTV5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTV8-1", "uniprot_id": "A0A8V0ZTV8_CHICK", "mass": 32426.0, "length": 307, "protein_name": "Ig-like domain-containing protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTX0-1", "uniprot_id": "A0A8V0ZTX0_CHICK", "mass": 92265.0, "length": 840, "protein_name": "Zinc finger protein 341", "gene_name": "ZNF341", "organism": "Chicken", "refseq_name": "zinc finger protein 341", "refseq_ac": "NP_001265022", "gene_names_uniprotkb": "ZNF341", "gene_names_refseq": "ZNF341", "protein_names_uniprotkb": "Zinc finger protein 341", "protein_names_refseq": "zinc finger protein 341", "tax_id": 9031, "disease": "", "pathway": " (gga:419152)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.211773.1, SRR13267659.257190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992533, SAMN02738221 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000328.1. On or before Oct 25, 2021 this sequence version replaced XP_015151835.2, NP_001265022.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001216 DNA-binding transcription activator activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTX8-1", "uniprot_id": "A0A8V0ZTX8_CHICK", "mass": 169462.0, "length": 1492, "protein_name": "Ovostatin", "gene_name": "OVSTL", "organism": "Chicken", "refseq_name": "ovostatin", "refseq_ac": "XP_040504344", "gene_names_uniprotkb": "OVSTL", "gene_names_refseq": "OVSTL", "protein_names_uniprotkb": "Ovostatin", "protein_names_refseq": "ovostatin", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTX9-1", "uniprot_id": "A0A8V0ZTX9_CHICK", "mass": 23249.0, "length": 219, "protein_name": "Peptidase S1 domain-containing protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Peptidase S1 domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTX9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTZ3-1", "uniprot_id": "A0A8V0ZTZ3_CHICK", "mass": 73059.0, "length": 656, "protein_name": "Ring finger protein 214", "gene_name": "RNF214", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RNF214", "gene_names_refseq": "", "protein_names_uniprotkb": "Ring finger protein 214", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:419767); (R-GGA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTZ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU10-1", "uniprot_id": "A0A8V0ZU10_CHICK", "mass": 103971.0, "length": 946, "protein_name": "Smoothelin", "gene_name": "SMTN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SMTN", "gene_names_refseq": "", "protein_names_uniprotkb": "Smoothelin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU11-1", "uniprot_id": "A0A8V0ZU11_CHICK", "mass": 35344.0, "length": 326, "protein_name": "Shisa family member 4", "gene_name": "SHISA4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SHISA4", "gene_names_refseq": "", "protein_names_uniprotkb": "Shisa family member 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU17-1", "uniprot_id": "A0A8V0ZU17_CHICK", "mass": 116333.0, "length": 1085, "protein_name": "L-fucose kinase", "gene_name": "FUK", "organism": "Chicken", "refseq_name": "L-fucose kinase isoform X1", "refseq_ac": "XP_015134701", "gene_names_uniprotkb": "FUK", "gene_names_refseq": "FUK", "protein_names_uniprotkb": "L-fucose kinase; 2.7.1.52", "protein_names_refseq": "L-fucose kinase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:770049); (R-GGA-6787639)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015134701.1. COMPLETENESS: full length., [RefSeq]; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.52", "go_molecular_function": "GO:0050201 fucokinase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "GO:0042352 GDP-L-fucose salvage;GO:0046835 carbohydrate phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU17-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU19-1", "uniprot_id": "A0A8V0ZU19_CHICK", "mass": 52181.0, "length": 480, "protein_name": "CCHC-type domain-containing protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "CCHC-type domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:0016032 viral process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU23-1", "uniprot_id": "A0A8V0ZU23_CHICK", "mass": 43495.0, "length": 407, "protein_name": "Solute carrier family 35 member C1", "gene_name": "SLC35C1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC35C1", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 35 member C1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6787639); (R-GGA-727802)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0005457 GDP-fucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0042352 GDP-L-fucose salvage;GO:0036085 GDP-fucose import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU28-1", "uniprot_id": "A0A8V0ZU28_CHICK", "mass": 28128.0, "length": 264, "protein_name": "Chymotrypsin like", "gene_name": "CTRL", "organism": "Chicken", "refseq_name": "chymotrypsin-like protease CTRL-1 precursor", "refseq_ac": "NP_001264554", "gene_names_uniprotkb": "CTRL", "gene_names_refseq": "CTRL", "protein_names_uniprotkb": "Chymotrypsin like", "protein_names_refseq": "chymotrypsin-like protease CTRL-1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:427531)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX935315.2, BX936273.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992453 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000247.1. On Sep 23, 2021 this sequence version replaced NP_001264554.1. Sequence Note: This RefSeq record was created with transcripts from different strains to make the sequence consistent with the transcript data., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU31-1", "uniprot_id": "A0A8V0ZU31_CHICK", "mass": 74572.0, "length": 689, "protein_name": "Tectonic family member 2", "gene_name": "TCTN2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TCTN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tectonic family member 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5620912)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036038 MKS complex", "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:1904491 protein localization to ciliary transition zone;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU31-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU40-1", "uniprot_id": "A0A8V0ZU40_CHICK", "mass": 9623.0, "length": 94, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU45-1", "uniprot_id": "A0A8V0ZU45_CHICK", "mass": 9888.0, "length": 85, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU45-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU58-1", "uniprot_id": "A0A8V0ZU58_CHICK", "mass": 62645.0, "length": 549, "protein_name": "RNA-binding region-containing protein 3", "gene_name": "RNPC3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RNPC3", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding region-containing protein 3; RNA-binding motif protein 40", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-72165)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0097157 pre-mRNA intronic binding;GO:0030626 U12 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU54-1", "uniprot_id": "A0A8V0ZU54_CHICK", "mass": 63211.0, "length": 556, "protein_name": "FAM20C golgi associated secretory pathway kinase", "gene_name": "FAM20C", "organism": "Chicken", "refseq_name": "extracellular serine/threonine protein kinase FAM20C", "refseq_ac": "XP_015149804", "gene_names_uniprotkb": "FAM20C", "gene_names_refseq": "FAM20C", "protein_names_uniprotkb": "FAM20C golgi associated secretory pathway kinase", "protein_names_refseq": "extracellular serine/threonine protein kinase FAM20C", "tax_id": 9031, "disease": "", "pathway": " (gga:416445); (R-GGA-381426); (R-GGA-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052545.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015149804.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0070166 enamel mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZU54-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZU57-1", "uniprot_id": "A0A8V0ZU57_CHICK", "mass": 17726.0, "length": 165, "protein_name": "Peptidase S1 domain-containing protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Peptidase S1 domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, 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The reference sequence was derived from JAENSK010000212.1. 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Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052558.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015154970.2. 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"protein_name": "Leucine rich repeat containing 27", "gene_name": "LRRC27", "organism": "Chicken", "refseq_name": "p53-induced death domain-containing protein 1", "refseq_ac": "XP_004941519", "gene_names_uniprotkb": "LRRC27", "gene_names_refseq": "LRRC27", "protein_names_uniprotkb": "Leucine rich repeat containing 27", "protein_names_refseq": "p53-induced death domain-containing protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:426464)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted 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This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004941519.3. 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This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015134386.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016459 myosin complex", "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0007015 actin filament organization;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZUJ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZUK0-1", "uniprot_id": "A0A8V0ZUK0_CHICK", "mass": 9783.0, "length": 86, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZUK0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NW85-1", "uniprot_id": "A0A1D5NW85_CHICK", "mass": 20187.0, "length": 178, "protein_name": "Extracellular fatty acid-binding protein", "gene_name": "EXFABP", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EXFABP", "gene_names_refseq": "", "protein_names_uniprotkb": "Extracellular fatty acid-binding protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396393); (R-GGA-804914)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070538 oleic acid binding;GO:0050544 arachidonate binding;GO:0070539 linoleic acid binding;GO:0070540 stearic acid binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006954 inflammatory response;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NW85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NXF3-1", "uniprot_id": "A0A1D5NXF3_CHICK", "mass": 78059.0, "length": 732, "protein_name": "T-box transcription factor 3", "gene_name": "TBX3", "organism": "Chicken", "refseq_name": "T-box transcription factor TBX3", "refseq_ac": "NP_001257807", "gene_names_uniprotkb": "TBX3", "gene_names_refseq": "TBX3", "protein_names_uniprotkb": "T-box transcription factor 3", "protein_names_refseq": "T-Box protein 3; T-box 3; T-box transcription factor TBX3", "tax_id": 9031, "disease": "", "pathway": " (gga:374202)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14723846", "class_list": "", "function": "Misexpression of Tbx2 and Tbx3 induced posterior homeotic transformation of digit III to digit IV and digit II to digit III, respectively. Erratum:[Dev Cell. 2005 Jun;8(6):971-2], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0032275 luteinizing hormone secretion;GO:0046884 follicle-stimulating hormone secretion;GO:0030540 female genitalia development;GO:0048752 semicircular canal morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5NXF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NYE8-1", "uniprot_id": "A0A1D5NYE8_CHICK", "mass": 85480.0, "length": 781, "protein_name": "Catenin beta 1", "gene_name": "CTNNB1", "organism": "Chicken", "refseq_name": "catenin beta-1", "refseq_ac": "NP_990412", "gene_names_uniprotkb": "CTNNB1", "gene_names_refseq": "CHBCAT; CTNNB1; beta-catenin", "protein_names_uniprotkb": "Catenin beta 1", "protein_names_refseq": "beta catenin; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1", "tax_id": 9031, "disease": "", "pathway": " (gga:395964); (R-GGA-195253); (R-GGA-196299); (R-GGA-201681); (R-GGA-201722); (R-GGA-3134973); (R-GGA-351906); (R-GGA-3769402); (R-GGA-4086398); (R-GGA-418990); (R-GGA-5218920); (R-GGA-525793); (R-GGA-8951430); (R-GGA-9762292); (R-GGA-9764561); (R-GGA-9766229); (R-GGA-9768727); (R-GGA-9825892); (R-GGA-9943962); (R-GGA-9958810); (R-GGA-9958825)", "pathway_count": 21, "publication_count": 6, "publication_id_list": "11290326;14991726;27218451;27664768;28842809;30009960", "class_list": "", "function": "Beta-catenin may be involved in regulating adhesive properties of cells during chick gastrulation, [RefSeq, PubMed]; Beta-catenin role in the cardiomyocyte differentiation during chick cardiogenesis., [RefSeq, PubMed]; CTNNB1 signaling is required for embryonic forelimb and hindlimb development and this WNT/CTNNB1 pathway is triggered by different WNT factors at different axial levels, [RefSeq, PubMed]; Cytoplasmic NOTCH and membrane-derived beta-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; We demonstrate that the balance of Ecad and Ncad is dependent upon the availability of beta-catenin proteins, and that alteration of either classical cadherin modifies the proportions of the neural crest and neuroectodermal cells that are specified, [RefSeq, PubMed]; We show that b-catenin is expressed during the pre-patterning of the epithelium prior to papilla induction and second that b-catenin, Ednrb and Inhba are expressed during the induction and patterning of the conjunctival papillae. Furthermore, we identified two genes, b-catenin and Prox1, that may be involved in the induction of the underlying scleral bones, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1RRU8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:0030997 regulation of centriole-centriole cohesion;GO:1904888 cranial skeletal system development;GO:0097091 synaptic vesicle clustering;GO:1901331 positive regulation of odontoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A1D5NYE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NYK7-1", "uniprot_id": "A0A1D5NYK7_CHICK", "mass": 68371.0, "length": 580, "protein_name": "Moesin", "gene_name": "MSN", "organism": "Chicken", "refseq_name": "moesin", "refseq_ac": "NP_001376296", "gene_names_uniprotkb": "MSN", "gene_names_refseq": "MSN", "protein_names_uniprotkb": "Moesin", "protein_names_refseq": "moesin", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-437239)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22219290", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267652.2558.1, SRR13267658.19149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1., [RefSeq]; Ezrin/radixin/moesin proteins organize actin filaments in sensory neuron growth cones and are crucial for neurotrophin-induced remodeling of F-actin and redistribution of adhesion receptors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0050839 cell adhesion molecule binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0022614 membrane to membrane docking;GO:0061028 establishment of endothelial barrier;GO:1902115 regulation of organelle assembly;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5NYK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NZL7-1", "uniprot_id": "A0A1D5NZL7_CHICK", "mass": 139213.0, "length": 1219, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase", "gene_name": "PLCB1", "organism": "Chicken", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1", "refseq_ac": "XP_025005026", "gene_names_uniprotkb": "PLCB1", "gene_names_refseq": "PLCB1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427687); (R-GGA-112043); (R-GGA-1855204); (R-GGA-399997); (R-GGA-4086398); (R-GGA-416476); (R-GGA-418217); (R-GGA-434316); (R-GGA-500657)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.11", "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0031965 nuclear membrane", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0070498 interleukin-1-mediated signaling pathway;GO:0060466 activation of meiosis involved in egg activation;GO:2000438 negative regulation of monocyte extravasation;GO:1903140 regulation of establishment of endothelial barrier", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NZL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5NZW4-1", "uniprot_id": "A0A1D5NZW4_CHICK", "mass": 31765.0, "length": 284, "protein_name": "Phospholipid phosphatase 1", "gene_name": "PLPP1", "organism": "Chicken", "refseq_name": "phospholipid phosphatase 1 isoform X1", "refseq_ac": "XP_004937297", "gene_names_uniprotkb": "PLPP1", "gene_names_refseq": "PLPP1", "protein_names_uniprotkb": "Phospholipid phosphatase 1; 3.1.3.106; 3.1.3.4; 3.6.1.75; Lipid phosphate phosphohydrolase 1; PAP2-alpha; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a", "protein_names_refseq": "phospholipid phosphatase 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427138); (R-GGA-9845614)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.4;3.1.3.106;3.6.1.75", "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0000810 diacylglycerol diphosphate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005901 caveola;GO:0005886 plasma membrane", "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation;GO:0006670 sphingosine metabolic process;GO:0007165 signal transduction;GO:0006672 ceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NZW4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5P088-1", "uniprot_id": "A0A1D5P088_CHICK", "mass": 77022.0, "length": 703, "protein_name": "Androgen receptor", "gene_name": "AR", "organism": "Chicken", "refseq_name": "androgen receptor", "refseq_ac": "NP_001035179", "gene_names_uniprotkb": "AR", "gene_names_refseq": "AR", "protein_names_uniprotkb": "Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4", "protein_names_refseq": "Kennedy disease); androgen receptor (dihydrotestosterone receptor; androgen receptor; spinal and bulbar muscular atrophy; testicular feminization", "tax_id": 9031, "disease": "", "pathway": " (gga:422165); (R-GGA-3371497); (R-GGA-383280); (R-GGA-4090294); (R-GGA-5689880); (R-GGA-8940973)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "16480982;18164879;18394591;19262415;22453555;28087386;32050491", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB193190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000071.1. On Sep 23, 2021 this sequence version replaced NP_001035179.1., [RefSeq]; A full-length androgen receptor (AR) cDNA from chicken (Gallus gallus) gonads was cloned and characterized., [RefSeq, PubMed]; Androgen receptor in early developmental stages of the nervous system; androgen receptor protein was located in the nucleus of neuroepithelial cells throughout the neural tube, [RefSeq, PubMed]; Androgens and AR signaling are essential for the development of lacunae and cortical cords in gonads of female embryos., [RefSeq, PubMed]; Cell-specific distribution of ERalpha and AR in the anterior pituitary from adult cockerels by immunohistochemistry, [RefSeq, PubMed]; Testosterone Promotes the Proliferation of Chicken Embryonic Myoblasts Via Androgen Receptor Mediated PI3K/Akt Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The androgen receptor might play a role in vocal development and that the molecular mechanism regulating the androgen receptor expression in the vocal areas might be important in the evolution of vocal learning., [RefSeq, PubMed]; Vitamin D3 and androgen receptors may be directly or indirectly involved in the development of the epididymal lithiasis in chickens., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003682 chromatin binding;GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "A0A1D5P088-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5P1S6-1", "uniprot_id": "A0A1D5P1S6_CHICK", "mass": 36532.0, "length": 333, "protein_name": "Homeobox protein", "gene_name": "PITX2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PITX2", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395862)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048731 system development;GO:0009887 animal organ morphogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1S6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5P1G4-1", "uniprot_id": "A0A1D5P1G4_CHICK", "mass": 40629.0, "length": 389, "protein_name": "POU domain protein", "gene_name": "POU4F1", "organism": "Chicken", "refseq_name": "POU domain, class 4, transcription factor 1", "refseq_ac": "XP_015132813", "gene_names_uniprotkb": "POU4F1", "gene_names_refseq": "POU4F1", "protein_names_uniprotkb": "POU domain protein", "protein_names_refseq": "POU domain, class 4, transcription factor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:100857623)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0051020 GTPase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043005 neuron projection;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0048880 sensory system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5P2P1-1", "uniprot_id": "A0A1D5P2P1_CHICK", "mass": 38296.0, "length": 351, "protein_name": "CCN family member 3", "gene_name": "CCN3", "organism": "Chicken", "refseq_name": "CCN family member 3 precursor", "refseq_ac": "NP_990599", "gene_names_uniprotkb": "CCN3", "gene_names_refseq": "CCN3; NOV", "protein_names_uniprotkb": "CCN family member 3; Cellular communication network factor 3; Nephroblastoma-overexpressed gene protein; Protein NOV", "protein_names_refseq": "CCN family member 3 precursor; CCN family member 3; nephroblastoma overexpressed; nephroblastoma-overexpressed gene protein; protein NOV", "tax_id": 9031, "disease": "", "pathway": " (gga:396204)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21931747;22038708", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X59284.1, SRR13267649.108912.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051, SAMN02738215 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. On Sep 23, 2021 this sequence version replaced NP_990599.1., [RefSeq]; Results establish the expression pattern of CCN3 in the developing retina, and show CCN3 expression is induced by activated BMP signaling, whereas Notch signaling decreases CCN3 mRNA and protein levels in Muller cells and has no effect in retinal neurons. Erratum:[Dev Neurobiol. 2013 Mar;73(3):257. Maryvonne, Laurent [corrected to Laurent, Maryvonne]; Gwenvael, Le Dreau [corrected to Le Dreau, Gwenvael]; Xavier, Guillonneau [corrected to Guillonneau, Xavier]; Cecile, Lelievre Elise [corrected to Lelievre, Elise]; Amelie, Slembrouck [corrected], [RefSeq, PubMed]; The expression of NOV was intense in the developing tendons and in the developing joints, whereas the chondrogenic blastemas were negative for NOV transcripts. NOV induced intense upregulation of Tenascin C and, at a reduced level, of alpha 5 Integrin, Sox9, and Activin beta-A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0005112 Notch binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031012 extracellular matrix;GO:0005921 gap junction;GO:0005576 extracellular region", "go_biological_process": "GO:0071603 endothelial cell-cell adhesion;GO:0090027 negative regulation of monocyte chemotaxis;GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5P2P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5P395-1", "uniprot_id": "A0A1D5P395_CHICK", "mass": 94805.0, "length": 841, "protein_name": "Axin-1", "gene_name": "AXIN1", "organism": "Chicken", "refseq_name": "axin-1", "refseq_ac": "NP_990275", "gene_names_uniprotkb": "AXIN1", "gene_names_refseq": "AXIN1-RGS; AXIN1; AXIN; axin-1", "protein_names_uniprotkb": "Axin-1; Axis inhibition protein 1", "protein_names_refseq": "axin-1; axis inhibition protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395786); (R-GGA-195253); (R-GGA-196299); (R-GGA-201681); (R-GGA-4641257); (R-GGA-4641262); (R-GGA-5689880)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "25528666", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF009012.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Sep 23, 2021 this sequence version replaced NP_990275.1., [RefSeq]; Study identifies GSK3beta as a serine/threonine kinase participating in intracellular signaling of Sema3A that induces acceleration of axonal transport, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PN57", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0031398 positive regulation of protein ubiquitination;GO:1904885 beta-catenin destruction complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5P395-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZTR7-1", "uniprot_id": "A0A8V0ZTR7_CHICK", "mass": 50150.0, "length": 433, "protein_name": "Rho GTPase activating protein 1", "gene_name": "ARHGAP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ARHGAP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho GTPase activating protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:428865); (R-GGA-8980692); (R-GGA-9013026); (R-GGA-9013106); (R-GGA-9013148); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013406); (R-GGA-9013408); (R-GGA-9013409); (R-GGA-9013423); (R-GGA-9035034); (R-GGA-9696270)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0016197 endosomal transport;GO:0033572 transferrin transport;GO:2001136 negative regulation of endocytic recycling;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZTR7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZSJ4-1", "uniprot_id": "A0A8V0ZSJ4_CHICK", "mass": 96284.0, "length": 838, "protein_name": "Proliferation-associated SNF2-like protein", "gene_name": "HELLS", "organism": "Chicken", "refseq_name": "lymphoid-specific helicase isoform X1", "refseq_ac": "XP_421626", "gene_names_uniprotkb": "HELLS", "gene_names_refseq": "HELLS", "protein_names_uniprotkb": "Proliferation-associated SNF2-like protein", "protein_names_refseq": "lymphoid-specific helicase isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052537.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_421626.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0051301 cell division;GO:0001822 kidney development;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZSJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZSC2-1", "uniprot_id": "A0A8V0ZSC2_CHICK", "mass": 219667.0, "length": 1991, "protein_name": "Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2", "gene_name": "TANC2", "organism": "Chicken", "refseq_name": "protein TANC2 isoform X10", "refseq_ac": "XP_015154872", "gene_names_uniprotkb": "TANC2", "gene_names_refseq": "TANC2", "protein_names_uniprotkb": "Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2", "protein_names_refseq": "protein TANC2 isoform X10", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052558.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015154872.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0043197 dendritic spine;GO:0098794 postsynapse", "go_biological_process": "GO:0061001 regulation of dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZSC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NSA8-1", "uniprot_id": "F1NSA8_CHICK", "mass": 21001.0, "length": 184, "protein_name": "small monomeric GTPase", "gene_name": "RAP1A", "organism": "Chicken", "refseq_name": "ras-related protein Rap-1A isoform X1", "refseq_ac": "XP_417994", "gene_names_uniprotkb": "RAP1A", "gene_names_refseq": "RAP1A", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "ras-related protein Rap-1A isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:419867); (R-GGA-170968); (R-GGA-170984); (R-GGA-354192); (R-GGA-354194); (R-GGA-372708); (R-GGA-381676); (R-GGA-392517); (R-GGA-5674135); (R-GGA-6798695); (R-GGA-8875555)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052557.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;6.2.1.3;3.6.5.5;2.7.11.1;7.6.2.1;3.6.5.-;3.2.2.6;3.1.3.48;3.6.5.3;3.1.4.4;1.14.14.18;2.7.10.2;3.6.1.5;2.7.11.24;2.3.1.51;2.7.10.1;3.4.21.73;3.6.4.-;1.14.19.17;5.2.1.-", "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity;GO:0003924 GTPase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NSA8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1N9Y5-1", "uniprot_id": "KSYK_CHICK", "mass": 69901.0, "length": 613, "protein_name": "Tyrosine-protein kinase SYK", "gene_name": "SYK", "organism": "Chicken", "refseq_name": "tyrosine-protein kinase SYK", "refseq_ac": "NP_001026601", "gene_names_uniprotkb": "SYK; RCJMB04_19o18", "gene_names_refseq": "SYK", "protein_names_uniprotkb": "Tyrosine-protein kinase SYK; 2.7.10.2", "protein_names_refseq": "spleen tyrosine kinase; tyrosine-protein kinase SYK", "tax_id": 9031, "disease": "", "pathway": " (gga:427272); (R-GGA-114604); (R-GGA-2029482); (R-GGA-2029485); (R-GGA-2454202); (R-GGA-2730905); (R-GGA-2871796); (R-GGA-2871809); (R-GGA-354192); (R-GGA-5621480); (R-GGA-912631); (R-GGA-9705462); (R-GGA-983695)", "pathway_count": 13, "publication_count": 9, "publication_id_list": "11434777;15592404;15642098;17452533;17913708;21606197;23223229;23335753;9697839", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720543.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000094.1. On Sep 23, 2021 this sequence version replaced NP_001026601.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of controlled B cell receptor triggering ex vivo and on primary murine B cells reveals that Src family kinases are required for signal initiation and Syk activation., [RefSeq, PubMed]; In hydrogen peroxide-stimulated DT40 cells, BLNK is phosphorylated by Syk and not by Btk., [RefSeq, PubMed]; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors., [UniProtKB, PubMed]; Results suggest that the uncommon recognition determinant of two closely spaced tyrosines is a limiting factor in NFAT signaling via Syk association with Vav1., [RefSeq, PubMed]; Syk tyrosine kinase has a role in signaling dynamics of the B cell antigen receptor, [RefSeq, PubMed]; The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters, [RefSeq, PubMed]; The simultaneous but not the independent suppression of Lyn and Syk expression prevents the activation of Ca2+-release activated Ca2+ current without interfering with thapsigargin-sensitive Ca(2+) store release in DT40 B lymphocyte cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZJ91", "ec_number_list": "2.7.12.2;3.1.4.11;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;3.6.5.2;2.3.2.27;2.7.11.1;2.7.1.153;2.7.1.137;2.7.10.4", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0001784 phosphotyrosine residue binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032009 early phagosome;GO:0005634 nucleus;GO:0042101 T cell receptor complex", "go_biological_process": "GO:0002366 leukocyte activation involved in immune response;GO:0002283 neutrophil activation involved in immune response;GO:0002554 serotonin secretion by platelet;GO:0010543 regulation of platelet activation;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "F1N9Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49147-1", "uniprot_id": "PA24A_CHICK", "mass": 84979.0, "length": 748, "protein_name": "Cytosolic phospholipase A2", "gene_name": "PLA2G4A", "organism": "Chicken", "refseq_name": "cytosolic phospholipase A2", "refseq_ac": "NP_990754", "gene_names_uniprotkb": "PLA2G4A; CPLA2; PLA2G4", "gene_names_refseq": "PLA2G4A; PLA2G4", "protein_names_uniprotkb": "Cytosolic phospholipase A2; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2 group IVA; cPLA2", "protein_names_refseq": "cPLA2; cytosolic phospholipase A2; phospholipase A2, group IVA (cytosolic, calcium-dependent)", "tax_id": 9031, "disease": "", "pathway": " (gga:396394); (R-GGA-111995); (R-GGA-1482788); (R-GGA-1482798); (R-GGA-1482801); (R-GGA-1482839); (R-GGA-1482922); (R-GGA-1482925); (R-GGA-1483115); (R-GGA-1483166); (R-GGA-2142753); (R-GGA-418592); (R-GGA-432142); (R-GGA-6811436)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "8027085", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U10329.1, SRR13267659.233825.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U10329.1., [RefSeq]; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.5;3.1.1.4;3.1.1.32;1.11.1.27;3.5.1.1;3.1.1.47;3.1.1.3;2.3.1.23", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005509 calcium ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0043032 positive regulation of macrophage activation;GO:0034638 phosphatidylcholine catabolic process;GO:0050482 arachidonate secretion;GO:0036151 phosphatidylcholine acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02977-1", "uniprot_id": "YRK_CHICK", "mass": 60002.0, "length": 536, "protein_name": "Proto-oncogene tyrosine-protein kinase Yrk", "gene_name": "FGR; YRK", "organism": "Chicken", "refseq_name": "proto-oncogene tyrosine-protein kinase Yrk isoform 1", "refseq_ac": "NP_001103257", "gene_names_uniprotkb": "FGR; YRK", "gene_names_refseq": "FGR; YRK", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase Yrk; 2.7.10.2; Yes-related kinase; p60-Yrk", "protein_names_refseq": "p60-Yrk; proto-oncogene tyrosine-protein kinase Yrk isoform 1; proto-oncogene tyrosine-protein kinase Yrk; yes-related kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:777583); (R-GGA-432142); (R-GGA-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8455940", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X67786.1, SRR13267649.199936.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000339.1., [RefSeq]; May participate in signaling pathways., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.186;2.7.12.2;2.7.11.24;1.11.1.24;2.7.10.2;2.7.10.1;4.1.2.13;2.7.12.1;3.6.4.13;2.4.2.7;5.3.1.9;2.7.1.1;4.2.99.18;5.6.2.4;2.7.1.35;3.6.4.6;4.1.2.4;2.7.11.23;5.2.1.8;2.4.1.1;5.4.2.11;5.4.2.4;3.5.4.5;2.7.1.40;1.1.1.42;2.4.1.25;3.2.1.33;3.1.1.47;2.7.1.11;1.11.1.6;1.13.11.34;5.3.2.1;5.3.3.12;4.2.1.24;2.7.11.1;3.5.4.6;2.7.4.6;2.7.10.4;3.6.5.-", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q02977-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5P3N0-1", "uniprot_id": "A0A1D5P3N0_CHICK", "mass": 76251.0, "length": 681, "protein_name": "Zinc finger CCCH-type containing 12A", "gene_name": "ZC3H12A", "organism": "Chicken", "refseq_name": "endoribonuclease ZC3H12A", "refseq_ac": "XP_417765", "gene_names_uniprotkb": "ZC3H12A", "gene_names_refseq": "ZC3H12A", "protein_names_uniprotkb": "Zinc finger CCCH-type containing 12A", "protein_names_refseq": "endoribonuclease ZC3H12A", "tax_id": 9031, "disease": "", "pathway": " (gga:419618)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052554.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_417765.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:1990869 cellular response to chemokine;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3N0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5P4G9-1", "uniprot_id": "A0A1D5P4G9_CHICK", "mass": 23040.0, "length": 219, "protein_name": "Achaete-scute family bHLH transcription factor 1", "gene_name": "ASCL1", "organism": "Chicken", "refseq_name": "achaete-scute homolog 1", "refseq_ac": "NP_989743", "gene_names_uniprotkb": "ASCL1", "gene_names_refseq": "ASCL1; CASH-1; CASH1", "protein_names_uniprotkb": "Achaete-scute family bHLH transcription factor 1", "protein_names_refseq": "achaete-scute complex homolog 1; achaete-scute complex-like 1; achaete-scute homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:386573)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15033166;15922575;19093008;20214951", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U01339.1, L11871.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Sep 30, 2021 this sequence version replaced NP_989743.1., [RefSeq]; A BMP-mediated transcriptional cascade involving Cash1 and Tlx-3 specifies first-order relay sensory neurons in the developing brainstem, [RefSeq, PubMed]; Induces neuronal differentiation characterized by the expression of generic neuronal genes SCG10, Hu and NF160, [RefSeq, PubMed]; There is a functional relationship between specific MTG and bHLH proteins in developing chick spinal cord., [RefSeq, PubMed]; This study explores the possibility of reprogramming retinal pigment epithelium progeny cells to differentiate toward retinal neurons with achaete-scute homolog 1 (ash1), a proneural gene that is expressed in progenitor cells in the developing retina., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0045665 negative regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A1D5P4G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5P8D7-1", "uniprot_id": "A0A1D5P8D7_CHICK", "mass": 90076.0, "length": 816, "protein_name": "Protein smoothened", "gene_name": "SMO", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SMO", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein smoothened", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395949); (R-GGA-5610787); (R-GGA-5632684); (R-GGA-5635838)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0005113 patched binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite", "go_biological_process": "GO:0060242 contact inhibition;GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:0021513 spinal cord dorsal/ventral patterning;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P8D7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PB14-1", "uniprot_id": "A0A1D5PB14_CHICK", "mass": 47657.0, "length": 431, "protein_name": "Mothers against decapentaplegic homolog", "gene_name": "SMAD6", "organism": "Chicken", "refseq_name": "SMAD family member 6", "refseq_ac": "NP_989579", "gene_names_uniprotkb": "SMAD6", "gene_names_refseq": "MADH6; SMAD6", "protein_names_uniprotkb": "Mothers against decapentaplegic homolog; MAD homolog; Mothers against DPP homolog; SMAD family member", "protein_names_refseq": "MAD homolog 6; SMAD family member 6; mothers against DPP homolog 6; mothers against decapentaplegic homolog 6", "tax_id": 9031, "disease": "", "pathway": " (gga:374096); (R-GGA-201451)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19352514;21730158", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF165889.1, FJ417094.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000246.1. On Nov 23, 2021 this sequence version replaced NP_989579.2., [RefSeq]; Report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation in the developing limb. Smad6 and Smad7a are expressed in dynamic patterns reflecting the domains of BMP gene expression in the limb, [RefSeq, PubMed]; Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/beta-catenin pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006955 immune response;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5PB14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PC88-1", "uniprot_id": "A0A1D5PC88_CHICK", "mass": 313043.0, "length": 2853, "protein_name": "APC regulator of WNT signaling pathway", "gene_name": "APC", "organism": "Chicken", "refseq_name": "adenomatous polyposis coli protein isoform X7", "refseq_ac": "XP_046761944", "gene_names_uniprotkb": "APC", "gene_names_refseq": "APC", "protein_names_uniprotkb": "APC regulator of WNT signaling pathway", "protein_names_refseq": "adenomatous polyposis coli protein isoform X7", "tax_id": 9031, "disease": "", "pathway": " (gga:415607); (R-GGA-111465); (R-GGA-195253); (R-GGA-196299); (R-GGA-3769402); (R-GGA-5689896)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0008013 beta-catenin binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0001708 cell fate specification;GO:0007399 nervous system development;GO:0008285 negative regulation of cell population proliferation;GO:0016477 cell migration;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PC88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PCB1-1", "uniprot_id": "A0A1D5PCB1_CHICK", "mass": 46606.0, "length": 442, "protein_name": "Forkhead box A1", "gene_name": "FOXA1", "organism": "Chicken", "refseq_name": "hepatocyte nuclear factor 3-alpha isoform X3", "refseq_ac": "XP_004941979", "gene_names_uniprotkb": "FOXA1", "gene_names_refseq": "FOXA1", "protein_names_uniprotkb": "Forkhead box A1", "protein_names_refseq": "hepatocyte nuclear factor 3-alpha isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:101752179); (R-GGA-9018519)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_004941979.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0019904 protein domain specific binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005902 microvillus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PCB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PCG4-1", "uniprot_id": "A0A1D5PCG4_CHICK", "mass": 47976.0, "length": 425, "protein_name": "Synaptotagmin 4", "gene_name": "SYT4", "organism": "Chicken", "refseq_name": "synaptotagmin-4 isoform X1", "refseq_ac": "XP_420894", "gene_names_uniprotkb": "SYT4", "gene_names_refseq": "SYT4", "protein_names_uniprotkb": "Synaptotagmin 4", "protein_names_refseq": "synaptotagmin-4 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:1903861 positive regulation of dendrite extension;GO:0050709 negative regulation of protein secretion;GO:0007613 memory;GO:0030100 regulation of endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PCG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PCX2-1", "uniprot_id": "A0A1D5PCX2_CHICK", "mass": 24820.0, "length": 220, "protein_name": "Charged multivesicular body protein 2A", "gene_name": "CHMP2A", "organism": "Chicken", "refseq_name": "charged multivesicular body protein 2a", "refseq_ac": "NP_001074361", "gene_names_uniprotkb": "CHMP2A", "gene_names_refseq": "CHMP2A", "protein_names_uniprotkb": "Charged multivesicular body protein 2A", "protein_names_refseq": "charged multivesicular body protein 2a; chromatin modifying protein 2A; chromatin-modifying protein 2a", "tax_id": 9031, "disease": "", "pathway": " (gga:776036); (R-GGA-1632852); (R-GGA-5620971); (R-GGA-917729); (R-GGA-9668328)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ721103.1, SRR13267649.91914.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000402.1. On Nov 4, 2021 this sequence version replaced NP_001074361.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0031210 phosphatidylcholine binding;GO:0180020 membrane bending activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010324 membrane invagination;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0039702 viral budding via host ESCRT complex", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PCX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PUY5-1", "uniprot_id": "A0A1D5PUY5_CHICK", "mass": 76703.0, "length": 672, "protein_name": "Protein kinase C", "gene_name": "PRKCB", "organism": "Chicken", "refseq_name": "protein kinase C beta type isoform X1", "refseq_ac": "XP_015149966", "gene_names_uniprotkb": "PRKCB", "gene_names_refseq": "PRKCB", "protein_names_uniprotkb": "Protein kinase C; 2.7.11.13", "protein_names_refseq": "protein kinase C beta type isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:416567); (R-GGA-114516); (R-GGA-1169091); (R-GGA-416993); (R-GGA-4419969); (R-GGA-5218921); (R-GGA-5668599); (R-GGA-76005)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052545.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.1.91;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;5.2.1.8;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0016020 membrane;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0008091 spectrin;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0050853 B cell receptor signaling pathway;GO:0018105 peptidyl-serine phosphorylation;GO:0010829 negative regulation of D-glucose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PUY5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PNE8-1", "uniprot_id": "A0A1D5PNE8_CHICK", "mass": 140335.0, "length": 1240, "protein_name": "Adenylate cyclase type 8", "gene_name": "ADCY8", "organism": "Chicken", "refseq_name": "adenylate cyclase type 8 isoform X1", "refseq_ac": "XP_418437", "gene_names_uniprotkb": "ADCY8", "gene_names_refseq": "ADCY8", "protein_names_uniprotkb": "Adenylate cyclase type 8; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 8 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420328); (R-GGA-163615); (R-GGA-170660); (R-GGA-170670); (R-GGA-418597); (R-GGA-5610787)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_418437.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.1", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity", "go_cellular_component": "GO:0005905 clathrin-coated pit;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0050796 regulation of insulin secretion;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PNE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PHB6-1", "uniprot_id": "A0A1D5PHB6_CHICK", "mass": 112654.0, "length": 987, "protein_name": "ATP-dependent DNA/RNA helicase DHX36", "gene_name": "DHX36", "organism": "Chicken", "refseq_name": "ATP-dependent DNA/RNA helicase DHX36", "refseq_ac": "XP_015147310", "gene_names_uniprotkb": "DHX36", "gene_names_refseq": "DHX36", "protein_names_uniprotkb": "ATP-dependent DNA/RNA helicase DHX36; 3.6.4.13; DEAD/H box polypeptide 36; MLE-like protein 1", "protein_names_refseq": "ATP-dependent DNA/RNA helicase DHX36", "tax_id": 9031, "disease": "", "pathway": " (gga:425032); (R-GGA-3134963)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0042826 histone deacetylase binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0032727 positive regulation of interferon-alpha production;GO:2000767 positive regulation of cytoplasmic translation;GO:0051891 positive regulation of cardioblast differentiation;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PHB6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PIQ5-1", "uniprot_id": "A0A1D5PIQ5_CHICK", "mass": 41458.0, "length": 360, "protein_name": "mitogen-activated protein kinase", "gene_name": "MAPK14", "organism": "Chicken", "refseq_name": "mitogen-activated protein kinase 14 isoform X1", "refseq_ac": "XP_001232616", "gene_names_uniprotkb": "MAPK14", "gene_names_refseq": "MAPK14", "protein_names_uniprotkb": "mitogen-activated protein kinase; 2.7.11.24", "protein_names_refseq": "mitogen-activated protein kinase 14 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:421183); (R-GGA-171007); (R-GGA-198753); (R-GGA-2559580); (R-GGA-418592); (R-GGA-432142); (R-GGA-4420097); (R-GGA-450302); (R-GGA-450341); (R-GGA-525793); (R-GGA-5668599); (R-GGA-6798695); (R-GGA-69601); (R-GGA-9824585)", "pathway_count": 14, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052557.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.186;2.7.12.2;2.7.11.24;1.11.1.24;2.3.3.8;3.2.1.31;2.7.10.2;4.1.2.13;3.4.22.52;3.6.4.13;2.4.2.7;2.3.2.5;5.3.1.9;3.4.22.1;2.7.1.1;3.3.2.6;4.2.99.18;5.6.2.4;2.7.1.35;2.3.2.27;3.6.4.6;4.1.2.4;3.4.24.35;5.2.1.8;3.2.1.23;2.4.1.1;5.4.2.11;5.4.2.4;3.5.4.5;2.7.1.40;1.1.1.42;2.4.1.25;3.2.1.33;3.1.1.47;2.7.1.11;1.11.1.6;1.13.11.34;3.4.19.1;2.7.11.1;3.1.3.48;5.3.2.1;5.3.3.12;4.2.1.24;3.6.1.6;3.5.4.6;3.1.6.14;5.4.2.2;2.7.10.1;2.7.4.6;1.16.3.1;3.4.23.5;3.6.5.2;3.6.5.-;3.5.1.23", "go_molecular_function": "GO:0051525 NFAT protein binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0048273 mitogen-activated protein kinase p38 binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0030316 osteoclast differentiation;GO:0071493 cellular response to UV-B;GO:0090400 stress-induced premature senescence;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PIQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PJQ2-1", "uniprot_id": "A0A1D5PJQ2_CHICK", "mass": 52265.0, "length": 468, "protein_name": "Peroxisome proliferator-activated receptor alpha", "gene_name": "PPARA", "organism": "Chicken", "refseq_name": "peroxisome proliferator-activated receptor alpha isoform X1", "refseq_ac": "XP_015145415", "gene_names_uniprotkb": "PPARA", "gene_names_refseq": "PPARA; PPAR", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1", "protein_names_refseq": "peroxisome proliferator-activated receptor alpha isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-383280); (R-GGA-400206); (R-GGA-4090294)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0008289 lipid binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001650 fibrillar center;GO:0016604 nuclear body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006631 fatty acid metabolic process;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PJQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PJX0-1", "uniprot_id": "A0A1D5PJX0_CHICK", "mass": 133383.0, "length": 1208, "protein_name": "Calcium-transporting ATPase", "gene_name": "ATP2B4", "organism": "Chicken", "refseq_name": "plasma membrane calcium-transporting ATPase 4 isoform X3", "refseq_ac": "XP_015154447", "gene_names_uniprotkb": "ATP2B4", "gene_names_refseq": "ATP2B4", "protein_names_uniprotkb": "Calcium-transporting ATPase; 7.2.2.10", "protein_names_refseq": "plasma membrane calcium-transporting ATPase 4 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-418359); (R-GGA-5578775); (R-GGA-936837)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052557.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.2.2.10;1.14.13.39", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0050998 nitric-oxide synthase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0036126 sperm flagellum;GO:0030018 Z disc", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0030317 flagellated sperm motility;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0071878 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PJX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PLJ8-1", "uniprot_id": "A0A1D5PLJ8_CHICK", "mass": 93463.0, "length": 810, "protein_name": "Calpain-3", "gene_name": "CAPN3", "organism": "Chicken", "refseq_name": "calpain-3", "refseq_ac": "NP_001004405", "gene_names_uniprotkb": "CAPN3", "gene_names_refseq": "CAPN3; p94", "protein_names_uniprotkb": "Calpain-3; 3.4.22.54", "protein_names_refseq": "CANP 3; calcium-activated neutral proteinase 3; calpain L3; calpain p94; calpain-3; muscle-specific calcium-activated neutral protease 3", "tax_id": 9031, "disease": "", "pathway": " (gga:423233)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19265533;21713405;32932207", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D38028.1, FJ497056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Mar 13, 2015 this sequence version replaced NP_001004405.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; CAPN3 polymorphisms are strongly associated with chicken carcass traits. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The present expression data of chicken CAPN3 gene may provide some information to shed light on the tissue and ontogenic expression pattern during chicken development., [RefSeq, PubMed]; The scaffolding protein calpain-3 has multiple distributions in embryonic chick muscle cells and it is essential for the formation of muscle fibers., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0031432 titin binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0071277 cellular response to calcium ion;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A1D5PLJ8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PLN4-1", "uniprot_id": "A0A1D5PLN4_CHICK", "mass": 49842.0, "length": 453, "protein_name": "Sequestosome 1", "gene_name": "SQSTM1", "organism": "Chicken", "refseq_name": "sequestosome-1 isoform X1", "refseq_ac": "XP_001233249", "gene_names_uniprotkb": "SQSTM1", "gene_names_refseq": "SQSTM1", "protein_names_uniprotkb": "Sequestosome 1", "protein_names_refseq": "sequestosome-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:770805); (R-GGA-205043); (R-GGA-209543); (R-GGA-209560); (R-GGA-5205685); (R-GGA-9020702); (R-GGA-9664873); (R-GGA-9755511)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_001233249.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030017 sarcomere;GO:0000932 P-body;GO:0016605 PML body", "go_biological_process": "GO:0001659 temperature homeostasis;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0097009 energy homeostasis;GO:0007032 endosome organization;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PLN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PM19-1", "uniprot_id": "A0A1D5PM19_CHICK", "mass": 226638.0, "length": 1960, "protein_name": "Myosin-9", "gene_name": "MYH9", "organism": "Chicken", "refseq_name": "myosin-9 isoform X1", "refseq_ac": "XP_040527622", "gene_names_uniprotkb": "MYH9", "gene_names_refseq": "MYH9; NMMHC; myosin; non-muscle; nonmuscle", "protein_names_uniprotkb": "Myosin-9; Cellular myosin heavy chain, type A; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa", "protein_names_refseq": "myosin-9 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5627123)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0005829 cytosol;GO:0005903 brush border", "go_biological_process": "GO:0001778 plasma membrane repair;GO:1903923 positive regulation of protein processing in phagocytic vesicle;GO:0001525 angiogenesis;GO:0006509 membrane protein ectodomain proteolysis;GO:0006911 phagocytosis, engulfment", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PM19-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2TTF7-1", "uniprot_id": "A0A3Q2TTF7_CHICK", "mass": 55918.0, "length": 503, "protein_name": "Scavenger receptor class B member 1", "gene_name": "SCARB1", "organism": "Chicken", "refseq_name": "scavenger receptor class B member 1 isoform X1", "refseq_ac": "XP_415106", "gene_names_uniprotkb": "SCARB1", "gene_names_refseq": "SCARB1", "protein_names_uniprotkb": "Scavenger receptor class B member 1; SR-BI", "protein_names_refseq": "scavenger receptor class B member 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:416814); (R-GGA-3000471); (R-GGA-8964011)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052546.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_415106.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070506 high-density lipoprotein particle receptor activity;GO:0005044 scavenger receptor activity;GO:0001540 amyloid-beta binding;GO:0008289 lipid binding;GO:0034186 apolipoprotein A-I binding", "go_cellular_component": "GO:0005901 caveola;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:0044406 adhesion of symbiont to host;GO:1902070 positive regulation of sphingolipid mediated signaling pathway;GO:0015914 phospholipid transport;GO:0033344 cholesterol efflux;GO:0034375 high-density lipoprotein particle remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2TTF7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PP00-1", "uniprot_id": "A0A1D5PP00_CHICK", "mass": 49589.0, "length": 492, "protein_name": "Serum response factor", "gene_name": "SRF", "organism": "Chicken", "refseq_name": "serum response factor", "refseq_ac": "NP_001239070", "gene_names_uniprotkb": "SRF", "gene_names_refseq": "SRF", "protein_names_uniprotkb": "Serum response factor", "protein_names_refseq": "serum response factor (c-fos serum response element-binding transcription factor); serum response factor", "tax_id": 9031, "disease": "", "pathway": " (gga:396103)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: JF803302.1, U50596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000060.1. On Sep 23, 2021 this sequence version replaced NP_001239070.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0010736 serum response element binding;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045987 positive regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PP00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PPP7-1", "uniprot_id": "CASP6_CHICK", "mass": 34476.0, "length": 304, "protein_name": "Caspase-6", "gene_name": "CASP6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CASP6", "gene_names_refseq": "", "protein_names_uniprotkb": "Caspase-6; 3.4.22.59; CASP-6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395477)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10684799;11953316;15592404", "class_list": "", "function": "Cysteine protease that plays essential roles in programmed cell death, development and innate immunity (PubMed:11953316). Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein lamin-A/LMNA thereby inducing nuclear shrinkage and fragmentation (PubMed:11953316). Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (PubMed:11953316). Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity. PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O93415", "ec_number_list": "", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030263 apoptotic chromosome condensation;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A1D5PPP7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PRD7-1", "uniprot_id": "A0A1D5PRD7_CHICK", "mass": 83995.0, "length": 772, "protein_name": "Glucocorticoid receptor", "gene_name": "NR3C1", "organism": "Chicken", "refseq_name": "glucocorticoid receptor isoform X1", "refseq_ac": "XP_046756343", "gene_names_uniprotkb": "NR3C1", "gene_names_refseq": "GR; NR3C1", "protein_names_uniprotkb": "Glucocorticoid receptor; Nuclear receptor subfamily 3 group C member 1", "protein_names_refseq": "glucocorticoid receptor isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3371497); (R-GGA-383280); (R-GGA-4090294)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004883 nuclear glucocorticoid receptor activity;GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0060126 somatotropin secreting cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PRD7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PRL4-1", "uniprot_id": "A0A1D5PRL4_CHICK", "mass": 50299.0, "length": 464, "protein_name": "Zic family member 3", "gene_name": "ZIC3", "organism": "Chicken", "refseq_name": "zinc finger protein ZIC 3", "refseq_ac": "XP_040526959", "gene_names_uniprotkb": "ZIC3", "gene_names_refseq": "ZIC3", "protein_names_uniprotkb": "Zic family member 3", "protein_names_refseq": "zinc finger protein ZIC 3", "tax_id": 9031, "disease": "", "pathway": " (gga:422251)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052576.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0030324 lung development;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PRL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PRR9-1", "uniprot_id": "FANCM_CHICK", "mass": 224006.0, "length": 2041, "protein_name": "Fanconi anemia group M protein", "gene_name": "FANCM", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FANCM", "gene_names_refseq": "", "protein_names_uniprotkb": "Fanconi anemia group M protein; 3.6.4.13; ATP-dependent RNA helicase FANCM; FAAP250; Fanconi anemia-associated polypeptide of 250 kDa; Protein FACM; Protein Hef ortholog", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:100857997)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15592404;16116434;19465393", "class_list": "", "function": "DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116434, PubMed:19465393). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork (By similarity). This activity is strongly stimulated in the presence of CENPS and CENPX (By similarity). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (By similarity). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0035825 homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A1D5PRR9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2U359-1", "uniprot_id": "A0A3Q2U359_CHICK", "mass": 102037.0, "length": 915, "protein_name": "Disks large homolog 1", "gene_name": "DLG1", "organism": "Chicken", "refseq_name": "disks large homolog 1 isoform X3", "refseq_ac": "XP_025009380", "gene_names_uniprotkb": "DLG1", "gene_names_refseq": "DLG1", "protein_names_uniprotkb": "Disks large homolog 1", "protein_names_refseq": "disks large homolog 1 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:424890); (R-GGA-438066); (R-GGA-5673001); (R-GGA-8849932)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019900 kinase binding;GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane;GO:0043005 neuron projection;GO:0070161 anchoring junction", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1902473 regulation of protein localization to synapse;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PU09-1", "uniprot_id": "A0A1D5PU09_CHICK", "mass": 81821.0, "length": 720, "protein_name": "FERM domain containing kindlin 2", "gene_name": "FERMT2", "organism": "Chicken", "refseq_name": "fermitin family homolog 2 isoform X2", "refseq_ac": "XP_004936584", "gene_names_uniprotkb": "FERMT2", "gene_names_refseq": "FERMT2", "protein_names_uniprotkb": "FERM domain containing kindlin 2", "protein_names_refseq": "fermitin family homolog 2 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:423589); (R-GGA-446353); (R-GGA-9013149); (R-GGA-9013423)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_004936584.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0051015 actin filament binding;GO:0046332 SMAD binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0001725 stress fiber", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0043116 negative regulation of vascular permeability;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PU09-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q3ACS4-1", "uniprot_id": "A0A3Q3ACS4_CHICK", "mass": 83800.0, "length": 724, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "organism": "Chicken", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1", "refseq_ac": "XP_015133112", "gene_names_uniprotkb": "PIK3R1", "gene_names_refseq": "PIK3R1", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha", "protein_names_refseq": "phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427171); (R-GGA-109704); (R-GGA-112399); (R-GGA-114604); (R-GGA-1250342); (R-GGA-1257604); (R-GGA-1266695); (R-GGA-1433557); (R-GGA-1660499); (R-GGA-180292); (R-GGA-186763); (R-GGA-1963642); (R-GGA-198203); (R-GGA-201556); (R-GGA-202424); (R-GGA-2029485); (R-GGA-210993); (R-GGA-2730905); (R-GGA-389357); (R-GGA-416476); (R-GGA-430116); (R-GGA-4420097); (R-GGA-512988); (R-GGA-5654689); (R-GGA-5654695); (R-GGA-5654710); (R-GGA-5654720); (R-GGA-5673001); (R-GGA-6811558); (R-GGA-8851907); (R-GGA-8853659); (R-GGA-8980692); (R-GGA-9009391); (R-GGA-9013026); (R-GGA-9013106); (R-GGA-9013148); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013408); (R-GGA-9013409); (R-GGA-9013420); (R-GGA-9013423); (R-GGA-9013424); (R-GGA-9027276); (R-GGA-9035034); (R-GGA-912526); (R-GGA-912631); (R-GGA-9607240); (R-GGA-9696264); (R-GGA-9696270); (R-GGA-983695); (R-GGA-9842663); (R-GGA-9927354)", "pathway_count": 53, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019209 kinase activator activity;GO:0001784 phosphotyrosine residue binding;GO:0005096 GTPase activator activity;GO:0005158 insulin receptor binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0005801 cis-Golgi network;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0007165 signal transduction;GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q3ACS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PUP4-1", "uniprot_id": "RECK_CHICK", "mass": 105701.0, "length": 963, "protein_name": "Reversion-inducing cysteine-rich protein with Kazal motifs", "gene_name": "RECK", "organism": "Chicken", "refseq_name": "reversion-inducing cysteine-rich protein with Kazal motifs isoform X1", "refseq_ac": "XP_418897", "gene_names_uniprotkb": "RECK", "gene_names_refseq": "RECK", "protein_names_uniprotkb": "Reversion-inducing cysteine-rich protein with Kazal motifs", "protein_names_refseq": "reversion-inducing cysteine-rich protein with Kazal motifs isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420804); (R-GGA-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15592404;23329048", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_418897.4. COMPLETENESS: full length., [RefSeq]; Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (By similarity). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PTW4", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0015026 coreceptor activity;GO:0004866 endopeptidase inhibitor activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:1990909 Wnt signalosome;GO:0098552 side of membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:1903053 regulation of extracellular matrix organization;GO:0001955 blood vessel maturation;GO:0060070 canonical Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5PUP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O73700-1", "uniprot_id": "CAC1D_CHICK", "mass": 249344.0, "length": 2190, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1D", "gene_name": "CACNA1D", "organism": "Chicken", "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1D", "refseq_ac": "NP_990365", "gene_names_uniprotkb": "CACNA1D", "gene_names_refseq": "CACNA1D", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1D; CHCACHA1D; Voltage-gated calcium channel subunit alpha Cav1.3", "protein_names_refseq": "CHCACHA1D; L-type voltage-gated calcium channel alpha1D subunit ChCaChA1D; calcium channel, voltage-dependent, L type, alpha 1D subunit; voltage-dependent L-type calcium channel subunit alpha-1D; voltage-gated calcium channel subunit alpha Cav1.3", "tax_id": 9031, "disease": "", "pathway": " (gga:395895); (R-GGA-422356)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11988172;18025474;9405708;9405709", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF027602.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JAENSK010000252.1. On Jan 18, 2005 this sequence version replaced XP_429273.1. This gene encodes a member of the voltage-dependent calcium channel protein subunit family. The cDNA for this gene was cloned from hair cells of the cochlea in the chicken inner ear. Study of the similar transmembrane protein in deficient mice reported impaired cardiac function and deafness, suggesting that the encoded protein is required for normal hearing and pacemaker activity in the heart. [provided by RefSeq, Aug 2012]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; A transient Ca(2+) current produced by the Ca(v)3.1 channel is expressed early in development to initiate spontaneous Ca(2+) spikes. Ca(v)1.3 currents, typical of mature hair cells, appeared later in development., [RefSeq, PubMed]; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group., [UniProtKB, UniProtKB]; The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group., [UniProtKB, UniProtKB]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O73701;O73702;O73703;O73704", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding;GO:0008331 high voltage-gated calcium channel activity;GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:1990454 L-type voltage-gated calcium channel complex;GO:0005891 voltage-gated calcium channel complex;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0030315 T-tubule", "go_biological_process": "GO:0086091 regulation of heart rate by cardiac conduction;GO:0007605 sensory perception of sound;GO:0051928 positive regulation of calcium ion transport;GO:0086002 cardiac muscle cell action potential involved in contraction;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O73700-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1D5PZB7-1", "uniprot_id": "A0A1D5PZB7_CHICK", "mass": 129628.0, "length": 1136, "protein_name": "Nitric oxide synthase", "gene_name": "NOS2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NOS2", "gene_names_refseq": "", "protein_names_uniprotkb": "Nitric oxide synthase; 1.14.13.39", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395807); (R-GGA-1222556); (R-GGA-392154); (R-GGA-9033241)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;1.14.13.39;4.1.3.4;4.1.2.63;2.3.1.137;4.1.1.9;3.6.1.77;5.3.3.21;2.3.1.42;3.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.2.27;3.4.24.56;1.3.1.38;3.4.21.-;1.1.1.42;1.5.3.13;1.11.1.6;1.1.3.15;2.6.1.51;2.6.1.44;1.1.1.35;4.2.1.17;5.3.3.8;2.3.1.176;2.3.1.16;2.3.1.155;2.3.1.7;1.5.3.1;1.5.3.7;2.5.1.18;1.3.1.124;5.1.99.4;3.6.1.-", "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0034617 tetrahydrobiopterin binding;GO:0005516 calmodulin binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0010629 negative regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0032755 positive regulation of interleukin-6 production;GO:0045776 negative regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZNW3-1", "uniprot_id": "A0A8V0ZNW3_CHICK", "mass": 70030.0, "length": 633, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 1", "gene_name": "ENTPD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ENTPD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 1; 3.6.1.5; ATP diphosphohydrolase; Ecto-ATP diphosphohydrolase 1; Ecto-apyrase; Lymphoid cell activation antigen; Nucleoside triphosphate diphosphohydrolase 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8850843)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates. This activity contributes to the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.5.2;3.6.4.13;3.6.5.5;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;3.6.1.6;2.7.4.3;3.6.5.-;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.3;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004050 apyrase activity;GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0005901 caveola;GO:0005886 plasma membrane", "go_biological_process": "GO:0070527 platelet aggregation;GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZNW3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27731-1", "uniprot_id": "TTHY_CHICK", "mass": 16309.0, "length": 150, "protein_name": "Transthyretin", "gene_name": "TTR", "organism": "Chicken", "refseq_name": "transthyretin isoform 1 precursor", "refseq_ac": "NP_990666", "gene_names_uniprotkb": "TTR", "gene_names_refseq": "TTR", "protein_names_uniprotkb": "Transthyretin; Prealbumin; TBPA", "protein_names_refseq": "TBPA; prealbumin; transthyretin isoform 1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396277)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1799976;18243807;1833190;21147258;28919452;8612621", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU269372.1, BU264821.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU269372.1, X60471.1, DN851840.1, BU339400.1 and BU352734.1. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Difference in triiodophenol(TIP) binding between female and male chickens; females bind less TIP than male adult and juvenile chickens., [RefSeq, PubMed]; Significant amount of diethylstilbestrol and ioxynil interacted with TTR in whole chicken serum., [RefSeq, PubMed]; TTR, Deiodinase 3 and OATP1C1 expression were found to be highly concentrated in the choroid plexus., [RefSeq, PubMed]; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0046982 protein heterodimerization activity;GO:0042562 hormone binding;GO:0070324 thyroid hormone binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030136 clathrin-coated vesicle;GO:0032991 protein-containing complex;GO:0060417 yolk;GO:0005576 extracellular region", "go_biological_process": "GO:0051262 protein tetramerization;GO:0042572 retinol metabolic process;GO:0009615 response to virus;GO:0070327 thyroid hormone transport;GO:0001555 oocyte growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P27731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A1L1RKB7-1", "uniprot_id": "A0A1L1RKB7_CHICK", "mass": 114779.0, "length": 1042, "protein_name": "Calcium-transporting ATPase", "gene_name": "ATP2A2", "organism": "Chicken", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2", "refseq_ac": "NP_001258903", "gene_names_uniprotkb": "ATP2A2", "gene_names_refseq": "ATP2A2; SERCA2", "protein_names_uniprotkb": "Calcium-transporting ATPase; 7.2.2.10", "protein_names_refseq": "ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; SR Ca(2+)-ATPase 2; calcium pump 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396446); (R-GGA-418359); (R-GGA-5578775); (R-GGA-936837)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.251676.1, SRR13267658.12997.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1. Sequence Note:., [RefSeq]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.2.2.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0005246 calcium channel regulator activity;GO:0016887 ATP hydrolysis activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0016020 membrane;GO:0033017 sarcoplasmic reticulum membrane;GO:0097470 ribbon synapse", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling;GO:0032470 positive regulation of endoplasmic reticulum calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RKB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZK92-1", "uniprot_id": "SPAST_CHICK", "mass": 66238.0, "length": 613, "protein_name": "Spastin", "gene_name": "SPAST", "organism": "Chicken", "refseq_name": "spastin", "refseq_ac": "NP_001026232", "gene_names_uniprotkb": "SPAST; RCJMB04_12e12; SPG4", "gene_names_refseq": "SPAST; SPG4", "protein_names_uniprotkb": "Spastin; 5.6.1.1", "protein_names_refseq": "neuronal spastin; spastin", "tax_id": 9031, "disease": "", "pathway": " (gga:421481); (R-GGA-9668328)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15592404;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720192.1, EU849599.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1. On Sep 23, 2021 this sequence version replaced NP_001026232.1., [RefSeq]; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B5AH49;B5AH50;E1C6S3", "ec_number_list": "3.6.4.6;5.6.1.1", "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0051013 microtubule severing;GO:0031117 positive regulation of microtubule depolymerization;GO:0051260 protein homooligomerization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZK92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22448-1", "uniprot_id": "RARB_CHICK", "mass": 50708.0, "length": 455, "protein_name": "Retinoic acid receptor beta", "gene_name": "RARB", "organism": "Chicken", "refseq_name": "retinoic acid receptor beta", "refseq_ac": "NP_990657", "gene_names_uniprotkb": "RARB; NR1B2", "gene_names_refseq": "NR1B2; RARBETA; RARB", "protein_names_uniprotkb": "Retinoic acid receptor beta; Nuclear receptor subfamily 1 group B member 2; RAR-beta", "protein_names_refseq": "RAR-beta; nuclear receptor subfamily 1 group B member 2; retinoic acid receptor beta 2; retinoic acid receptor beta4'; retinoic acid receptor beta4M'; retinoic acid receptor beta", "tax_id": 9031, "disease": "", "pathway": " (gga:396266); (R-GGA-383280)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1647216;1652423;1848357;1849630;1849811;25663354;7703521", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X57341.1, SRR13267656.13968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1. Sequence Note: This sequence has been modified as follows: removed 36 bp suspected to be vector contamination from the 3' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for limb and craniofacial development., [UniProtKB, PubMed, PubMed]; Study showed that RARB expression was vital for the timely execution of programmed cell death and was furthermore seen to have an influence on the differentiation state of the ciliary ganglion neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P27537;Q90598;Q91354", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P22448-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2TTB3-1", "uniprot_id": "PRIPO_CHICK", "mass": 65865.0, "length": 574, "protein_name": "DNA-directed primase/polymerase protein", "gene_name": "PRIMPOL", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PRIMPOL", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-directed primase/polymerase protein; 2.7.7.102; 2.7.7.7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "15592404;26626482;26694751;27230014;30478192", "class_list": "", "function": "DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them (PubMed:26626482, PubMed:30478192). Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions (PubMed:26694751, PubMed:27230014). Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as UV lesions, R-loops and G-quadruplexes, to allow DNA replication to continue (PubMed:26626482, PubMed:26694751, PubMed:27230014). Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion. Repriming avoids fork degradation while leading to accumulation of internal ssDNA gaps behind the forks (By similarity). Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase (By similarity). Also required for reinitiating stalled forks after ultraviolet (UV) damage during nuclear DNA replication (By similarity). Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (By similarity). In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q2UFR8;E1BS13", "ec_number_list": "2.7.7.7;2.7.7.102;2.7.7.49;3.6.4.12;2.7.7.31", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0030145 manganese ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005759 mitochondrial matrix;GO:0005657 replication fork;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0009411 response to UV;GO:0019985 translesion synthesis;GO:0006264 mitochondrial DNA replication;GO:0043504 mitochondrial DNA repair;GO:0042276 error-prone translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A3Q2TTB3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2TTH8-1", "uniprot_id": "A0A3Q2TTH8_CHICK", "mass": 29455.0, "length": 261, "protein_name": "Fibroblast growth factor 10", "gene_name": "FGF10", "organism": "Chicken", "refseq_name": "fibroblast growth factor 10 isoform X1", "refseq_ac": "XP_040511292", "gene_names_uniprotkb": "FGF10", "gene_names_refseq": "FGF10; FGF", "protein_names_uniprotkb": "Fibroblast growth factor 10", "protein_names_refseq": "fibroblast growth factor 10 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-109704); (R-GGA-1257604); (R-GGA-190370); (R-GGA-190377); (R-GGA-5654219); (R-GGA-5654221); (R-GGA-5654687); (R-GGA-5654688); (R-GGA-5654689); (R-GGA-5654693); (R-GGA-5654695); (R-GGA-5654699); (R-GGA-5654700); (R-GGA-5654726); (R-GGA-5654727); (R-GGA-5658623); (R-GGA-5673001); (R-GGA-6811558)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0030036 actin cytoskeleton organization;GO:0051549 positive regulation of keratinocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2TTH8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05713-1", "uniprot_id": "CRYAB_CHICK", "mass": 20034.0, "length": 174, "protein_name": "Alpha-crystallin B chain", "gene_name": "CRYAB", "organism": "Chicken", "refseq_name": "alpha-crystallin B chain", "refseq_ac": "NP_990507", "gene_names_uniprotkb": "CRYAB", "gene_names_refseq": "CRYAB; alpha(B)-crystallin", "protein_names_uniprotkb": "Alpha-crystallin B chain; Alpha(B)-crystallin", "protein_names_refseq": "HspB5 protein; alpha B-crystallin; alpha-crystallin B chain", "tax_id": 9031, "disease": "", "pathway": " (gga:396089); (R-GGA-3371571)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1283129;19878675;20872245;26139560;27857180;9099889", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: S53164.1, HAEK01073202.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000341.1. On Nov 5, 2021 this sequence version replaced NP_990507.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Data demonstrate that peripapillary glial cells express alphaB-crystallin, which is not expressed in Muller cells, during retinal development., [RefSeq, PubMed]; ELISAs indicated aspirin (ASA) induced CryAB in vivo to protect against heat stress-induced myocardial damage, but ASA did not induce CryAB in primary chicken myocardial cells. Publication Status: Online-Only, [RefSeq, PubMed]; May contribute to the transparency and refractive index of the lens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; No significant changes in retinal cryab RNA transcript expression were seen in response to plus lenses compared to either contralateral control values, [RefSeq, PubMed]; These results suggest that HSPB1 protein forms complexes with alphaB-crystallin in aged chicken muscle and suppose to become the candidate of age-related bio-marker for verifying the age of chicken meat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90657", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0050821 protein stabilization;GO:0031333 negative regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05713-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2U125-1", "uniprot_id": "A0A3Q2U125_CHICK", "mass": 11970.0, "length": 108, "protein_name": "C-C motif chemokine", "gene_name": "LOC100857191", "organism": "Chicken", "refseq_name": "C-C motif chemokine 26", "refseq_ac": "XP_003643029", "gene_names_uniprotkb": "LOC100857191", "gene_names_refseq": "LOC100857191", "protein_names_uniprotkb": "C-C motif chemokine", "protein_names_refseq": "C-C motif chemokine 26", "tax_id": 9031, "disease": "", "pathway": " (gga:100857191)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:2000669 negative regulation of dendritic cell apoptotic process;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0046330 positive regulation of JNK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0YJP6-1", "uniprot_id": "A0A8V0YJP6_CHICK", "mass": 55106.0, "length": 497, "protein_name": "Alanine--glyoxylate aminotransferase 2, mitochondrial", "gene_name": "AGXT2", "organism": "Chicken", "refseq_name": "alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1", "refseq_ac": "XP_040512452", "gene_names_uniprotkb": "AGXT2", "gene_names_refseq": "AGXT2", "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase 2, mitochondrial; (R)-3-amino-2-methylpropionate--pyruvate transaminase; 2.6.1.18; 2.6.1.40; 2.6.1.44; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase", "protein_names_refseq": "alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:431666); (R-GGA-389661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.6.1.40;2.6.1.44;2.6.1.18;2.6.1.51", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008453 alanine-glyoxylate transaminase activity;GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity;GO:0016223 beta-alanine:pyruvate transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0009436 glyoxylate catabolic process;GO:0019265 glycine biosynthetic process, by transamination of glyoxylate;GO:0019481 L-alanine catabolic process, by transamination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0YJP6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2U639-1", "uniprot_id": "A0A3Q2U639_CHICK", "mass": 66431.0, "length": 589, "protein_name": "Tyrosine-protein kinase", "gene_name": "FYN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FYN", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396294); (R-GGA-1227986); (R-GGA-1257604); (R-GGA-1433557); (R-GGA-1433559); (R-GGA-210990); (R-GGA-373753); (R-GGA-375165); (R-GGA-389356); (R-GGA-389357); (R-GGA-389359); (R-GGA-389513); (R-GGA-3928662); (R-GGA-3928663); (R-GGA-3928664); (R-GGA-3928665); (R-GGA-399954); (R-GGA-399955); (R-GGA-399956); (R-GGA-4420097); (R-GGA-5621575); (R-GGA-5673001); (R-GGA-6811558); (R-GGA-8866376); (R-GGA-9032759); (R-GGA-912631); (R-GGA-9766229)", "pathway_count": 27, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.11.24;2.7.10.2;2.7.10.1;2.7.11.17;2.7.12.1;3.6.5.2;2.7.11.23;3.1.3.48;2.7.11.1;2.3.2.27;2.7.11.26;2.7.1.153;2.7.1.137;2.7.1.154;2.7.10.4", "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:1904646 cellular response to amyloid-beta", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U639-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2U6I3-1", "uniprot_id": "A0A3Q2U6I3_CHICK", "mass": 59329.0, "length": 543, "protein_name": "Amino acid transporter", "gene_name": "SLC1A3", "organism": "Chicken", "refseq_name": "excitatory amino acid transporter 1", "refseq_ac": "XP_425011", "gene_names_uniprotkb": "SLC1A3", "gene_names_refseq": "SLC1A3", "protein_names_uniprotkb": "Amino acid transporter", "protein_names_refseq": "excitatory amino acid transporter 1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-210455); (R-GGA-210500); (R-GGA-9958863)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_425011.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity;GO:0016595 glutamate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0070779 D-aspartate import across plasma membrane;GO:0071805 potassium ion transmembrane transport;GO:0098712 L-glutamate import across plasma membrane;GO:0140009 L-aspartate import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U6I3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2UH91-1", "uniprot_id": "A0A3Q2UH91_CHICK", "mass": 59335.0, "length": 519, "protein_name": "Nuclear receptor subfamily 1 group H member 3", "gene_name": "NR1H3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NR1H3", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group H member 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-383280); (R-GGA-4090294); (R-GGA-8866427); (R-GGA-9029569)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043235 receptor complex;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006629 lipid metabolic process;GO:0048550 negative regulation of pinocytosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010875 positive regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UH91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2UCN1-1", "uniprot_id": "A0A3Q2UCN1_CHICK", "mass": 68456.0, "length": 606, "protein_name": "Tyrosine-protein phosphatase non-receptor type", "gene_name": "PTPN6", "organism": "Chicken", "refseq_name": "tyrosine-protein phosphatase non-receptor type 6 isoform X1", "refseq_ac": "XP_015149007", "gene_names_uniprotkb": "PTPN6", "gene_names_refseq": "PTPN6", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 6 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427947); (R-GGA-1433559); (R-GGA-201556); (R-GGA-210990); (R-GGA-389948); (R-GGA-432142); (R-GGA-512988); (R-GGA-6798695); (R-GGA-877300); (R-GGA-912526); (R-GGA-912694)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015149007.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;3.4.21.4;2.7.10.2;4.1.2.13;3.4.19.9;3.2.1.166;3.5.1.3;2.3.2.5;1.8.3.2;3.3.2.6;2.7.1.35;3.4.24.35;2.7.10.1;3.5.4.5;3.1.3.67;3.6.5.2;3.4.21.41;1.1.1.42;1.4.3.-;3.6.1.6;3.4.24.7;3.1.3.21;5.4.2.2;3.2.1.17;1.16.3.1;3.4.23.5;3.1.3.18;3.1.3.2;5.3.99.2;3.5.1.23", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0050839 cell adhesion molecule binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UCN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2UE42-1", "uniprot_id": "A0A3Q2UE42_CHICK", "mass": 52691.0, "length": 468, "protein_name": "Presenilin", "gene_name": "PSEN1", "organism": "Chicken", "refseq_name": "presenilin-1 isoform X1", "refseq_ac": "XP_015142400", "gene_names_uniprotkb": "PSEN1", "gene_names_refseq": "PS-1; PSEN1; presenilin-1", "protein_names_uniprotkb": "Presenilin; 3.4.23.-", "protein_names_refseq": "presenilin-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1251985); (R-GGA-193692); (R-GGA-205043); (R-GGA-3928665); (R-GGA-6798695); (R-GGA-9013507); (R-GGA-9017802); (R-GGA-9839383)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.16.2;7.6.2.1;3.4.23.-;2.4.1.90;2.5.1.18;2.7.10.1;3.2.1.25;3.1.3.2;3.6.5.2;2.3.2.27", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005262 calcium channel activity;GO:0051117 ATPase binding;GO:0070851 growth factor receptor binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005790 smooth endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002265 astrocyte activation involved in immune response;GO:0006509 membrane protein ectodomain proteolysis;GO:0007155 cell adhesion;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UE42-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2UHM4-1", "uniprot_id": "A0A3Q2UHM4_CHICK", "mass": 81655.0, "length": 735, "protein_name": "Dynamin-1-like protein", "gene_name": "DNM1L", "organism": "Chicken", "refseq_name": "dynamin-1-like protein isoform X2", "refseq_ac": "XP_015141156", "gene_names_uniprotkb": "DNM1L", "gene_names_refseq": "DNM1L", "protein_names_uniprotkb": "Dynamin-1-like protein; 3.6.5.5", "protein_names_refseq": "dynamin-1-like protein isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-75153)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0099073 mitochondrion-derived vesicle;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0090149 mitochondrial membrane fission;GO:1900063 regulation of peroxisome organization;GO:0006897 endocytosis;GO:0016559 peroxisome fission;GO:0051259 protein complex oligomerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UHM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q2UKD3-1", "uniprot_id": "A0A3Q2UKD3_CHICK", "mass": 126361.0, "length": 1128, "protein_name": "Angiopoietin-1 receptor", "gene_name": "TEK", "organism": "Chicken", "refseq_name": "angiopoietin-1 receptor", "refseq_ac": "XP_004949637", "gene_names_uniprotkb": "TEK", "gene_names_refseq": "TEK", "protein_names_uniprotkb": "Angiopoietin-1 receptor; 2.7.10.1; Endothelial tyrosine kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TIE-2", "protein_names_refseq": "angiopoietin-1 receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:427368); (R-GGA-210993); (R-GGA-5673001)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.11.17;2.7.12.1;2.7.11.23;3.1.3.48;2.7.11.1;3.6.5.2;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion", "go_biological_process": "GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UKD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O12940-1", "uniprot_id": "TOM1_CHICK", "mass": 57024.0, "length": 515, "protein_name": "Target of Myb1 membrane trafficking protein", "gene_name": "TOM1", "organism": "Chicken", "refseq_name": "target of Myb1 membrane trafficking protein", "refseq_ac": "NP_990475", "gene_names_uniprotkb": "TOM1", "gene_names_refseq": "TOM-1B; TOM1; tom-1A", "protein_names_uniprotkb": "Target of Myb1 membrane trafficking protein; Target of Myb protein 1; Tom-1", "protein_names_refseq": "target of Myb protein 1; target of Myb1 membrane trafficking protein; tom-1", "tax_id": 9031, "disease": "", "pathway": " (gga:396049); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9135152", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y08741.1, SRR13267654.211457.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (By similarity). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures (By similarity). Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes (By similarity). MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (By similarity). Binds to polyubiquitinated proteins via its GAT domain (By similarity). In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (By similarity). Mediates clathrin recruitment to early endosomes (By similarity). Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking (By similarity). Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation (By similarity). PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation (By similarity). Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O12941", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0030276 clathrin binding;GO:0043130 ubiquitin binding;GO:0070853 myosin VI binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport;GO:0016197 endosomal transport;GO:1901098 positive regulation of autophagosome maturation;GO:1904978 regulation of endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O12940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C656-1", "uniprot_id": "HACE1_CHICK", "mass": 106295.0, "length": 942, "protein_name": "E3 ubiquitin-protein ligase HACE1", "gene_name": "HACE1", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase HACE1", "refseq_ac": "NP_001265084", "gene_names_uniprotkb": "HACE1; RCJMB04_37k12", "gene_names_refseq": "HACE1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HACE1; 2.3.2.26; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1", "protein_names_refseq": "E3 ubiquitin-protein ligase HACE1; HECT-type E3 ubiquitin transferase HACE1", "tax_id": 9031, "disease": "", "pathway": " (gga:421788); (R-GGA-983168); (R-GGA-9958825)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15592404;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.83714.1, SRR13267661.3916.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000065.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5F340", "ec_number_list": "2.3.2.23;2.3.2.27;2.3.2.26;2.3.2.24;2.3.2.31;3.6.5.2;2.7.11.1;6.2.1.45;3.6.4.-;2.3.2.34", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0030334 regulation of cell migration;GO:0061025 membrane fusion;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1C656-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q3AS57-1", "uniprot_id": "A0A3Q3AS57_CHICK", "mass": 110976.0, "length": 984, "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoblastoma-associated protein; pRb", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:386582); (R-GGA-174178); (R-GGA-2299718); (R-GGA-2559584); (R-GGA-69200); (R-GGA-69202); (R-GGA-69231); (R-GGA-69656); (R-GGA-9841922)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051219 phosphoprotein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0016605 PML body;GO:0000785 chromatin;GO:0035189 Rb-E2F complex", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:1904761 negative regulation of myofibroblast differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q3AS57-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3Q3ATU9-1", "uniprot_id": "A0A3Q3ATU9_CHICK", "mass": 29337.0, "length": 260, "protein_name": "Protein odd-skipped-related 1", "gene_name": "OSR1", "organism": "Chicken", "refseq_name": "protein odd-skipped-related 1", "refseq_ac": "NP_001385123", "gene_names_uniprotkb": "OSR1", "gene_names_refseq": "ODD; OSR1", "protein_names_uniprotkb": "Protein odd-skipped-related 1", "protein_names_refseq": "odd-skipped homolog; protein odd-skipped-related 1", "tax_id": 9031, "disease": "", "pathway": " (gga:100316920)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888502.297230.1, SRR12888493.258138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000067.1. On Dec 9, 2021 this sequence version replaced XP_015140433.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0072180 mesonephric duct morphogenesis;GO:0072143 mesangial cell development;GO:0072162 metanephric mesenchymal cell differentiation;GO:0072168 specification of anterior mesonephric tubule identity;GO:0072169 specification of posterior mesonephric tubule identity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q3ATU9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A3S5ZPN3-1", "uniprot_id": "A0A3S5ZPN3_CHICK", "mass": 67673.0, "length": 603, "protein_name": "Probable ATP-dependent RNA helicase DDX5", "gene_name": "DDX5", "organism": "Chicken", "refseq_name": "probable ATP-dependent RNA helicase DDX5 isoform X1", "refseq_ac": "XP_015135357", "gene_names_uniprotkb": "DDX5", "gene_names_refseq": "DDX5", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX5; 3.6.4.13; DEAD box protein 5", "protein_names_refseq": "probable ATP-dependent RNA helicase DDX5 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3899300); (R-GGA-72163); (R-GGA-9018519); (R-GGA-9770562)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052549.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.2.1.8;2.3.2.27;2.3.1.48;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;2.7.7.19;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;3.1.3.16;2.7.7.7;2.7.7.49;2.7.7.6;3.1.3.1;3.6.1.15;3.1.3.53;2.3.2.-;3.6.1.-;2.7.1.78", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030509 BMP signaling pathway;GO:0048511 rhythmic process;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3S5ZPN3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05625-1", "uniprot_id": "RAF1_CHICK", "mass": 73125.0, "length": 647, "protein_name": "RAF proto-oncogene serine/threonine-protein kinase", "gene_name": "RAF1", "organism": "Chicken", "refseq_name": "RAF proto-oncogene serine/threonine-protein kinase", "refseq_ac": "NP_990638", "gene_names_uniprotkb": "RAF1; MIL", "gene_names_refseq": "MIL; RAF1", "protein_names_uniprotkb": "RAF proto-oncogene serine/threonine-protein kinase; 2.7.11.1; C-MIL; C-RAF; MIL proto-oncogene serine/threonine-protein kinase; RAF-1", "protein_names_refseq": "C-RAF; MIL proto-oncogene serine/threonine-protein kinase; RAF proto-oncogene serine/threonine-protein kinase; c-mil protein; v-raf-1 murine leukemia viral oncogene homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396245); (R-GGA-2672351); (R-GGA-392517); (R-GGA-430116); (R-GGA-5621575); (R-GGA-5673000); (R-GGA-5674135); (R-GGA-5674499); (R-GGA-5675221); (R-GGA-9732724)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "12411479;12843393;12952943;14968114;1886707;21203386;2837658;2998016;3002017;3285296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X07017.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X07017.1., [RefSeq]; A complete map of the c-mil/raf-1 gene and a revision of the exon numbers, [RefSeq, PubMed]; Inducible gene deletion of the c-mil/raf-1 gene in chicken DT40 B cells revealed that, in addition to B-Raf, Raf-1 acts as an accessory ERK activator following engagement of the B cell antigen receptor., [RefSeq, PubMed]; RAF kinase activity is essential to establish the balance between cell proliferation and death in neuroepithelial otic precursors, and for otic neuron differentiation and axonal growth at the acoustic-vestibular ganglion Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q90893;Q90894", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.10.2;2.3.2.26;2.7.11.22;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;3.1.3.16;2.3.2.27;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;3.6.5.2;3.6.4.-;3.1.3.53;2.7.11.11", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P05625-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4KWZ6-1", "uniprot_id": "MD2L2_CHICK", "mass": 24346.0, "length": 211, "protein_name": "Mitotic spindle assembly checkpoint protein MAD2B", "gene_name": "MAD2L2", "organism": "Chicken", "refseq_name": "mitotic spindle assembly checkpoint protein MAD2B", "refseq_ac": "NP_001020749", "gene_names_uniprotkb": "MAD2L2; REV7", "gene_names_refseq": "MAD2L2; REV7", "protein_names_uniprotkb": "Mitotic spindle assembly checkpoint protein MAD2B; MAD2-like protein 2; Mitotic arrest deficient 2-like protein 2", "protein_names_refseq": "MAD2 homolog; MAD2 mitotic arrest deficient-like 2; MAD2-like protein 2; mitotic arrest deficient 2-like protein 2; mitotic spindle assembly checkpoint protein MAD2B", "tax_id": 9031, "disease": "", "pathway": " (gga:419493); (R-GGA-110312); (R-GGA-353299); (R-GGA-353473); (R-GGA-5655862); (R-GGA-5656121); (R-GGA-5656169)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "15988022;16424005;20164194", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000950.1, HAEK01113013.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000329.1. On Jul 18, 2005 this sequence version replaced XP_417648.1., [RefSeq]; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (By similarity). Through transcriptional regulation may play a role in epithelial-mesenchymal transdifferentiation., [UniProtKB, PubMed, PubMed, UniProtKB]; Present study proves that polymerase zeta is a critical factor for tolerating nitric oxide (NO) toxicity and prevents chromosomal breaks probably by releasing replication block at NO-damaged template strands, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017125 deoxycytidyl transferase activity;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0051301 cell division;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4KWZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02609-1", "uniprot_id": "MYL11_CHICK", "mass": 18839.0, "length": 168, "protein_name": "Myosin regulatory light chain 11", "gene_name": "MYL11; MYLPF", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYL11; MYLPF; MYLPF; RLC", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin regulatory light chain 11; DTNB; Fast skeletal myosin light chain 2; G2; LC2f; MLC-2; Myosin light chain 11; Myosin regulatory light chain 2, skeletal muscle isoform", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:776775); (R-GGA-445355)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15256600;2580100;3979397;7358336;8316857", "class_list": "", "function": "Myosin regulatory subunit that plays an essential to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (PubMed:15256600)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90915", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016459 myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02609-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76I89-1", "uniprot_id": "NDC80_CHICK", "mass": 73741.0, "length": 640, "protein_name": "Kinetochore protein NDC80 homolog", "gene_name": "NDC80", "organism": "Chicken", "refseq_name": "kinetochore protein NDC80 homolog", "refseq_ac": "NP_989808", "gene_names_uniprotkb": "NDC80; HEC1; KNTC2; RCJMB04_4o15", "gene_names_refseq": "HEC1; KNTC2; NDC80", "protein_names_uniprotkb": "Kinetochore protein NDC80 homolog; Kinetochore protein Hec1; Kinetochore-associated protein 2", "protein_names_refseq": "NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395134); (R-GGA-141430); (R-GGA-141444); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-5663220); (R-GGA-9648025)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "12829748;15642098;15713649;15870271;21464230;35165266", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719646.1, AB098622.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000043.1. On Sep 23, 2021 this sequence version replaced NP_989808.2., [RefSeq]; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZLT8", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0030332 cyclin binding;GO:0140483 kinetochore adaptor activity", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0000776 kinetochore", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q76I89-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0X804-1", "uniprot_id": "A0A8V0X804_CHICK", "mass": 129030.0, "length": 1304, "protein_name": "Hormone-sensitive lipase", "gene_name": "LIPE", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LIPE", "gene_names_refseq": "", "protein_names_uniprotkb": "Hormone-sensitive lipase; 3.1.1.23; 3.1.1.79; Monoacylglycerol lipase LIPE; Retinyl ester hydrolase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.32;3.1.1.3;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.5;3.1.1.116;3.5.1.99;3.1.1.-;3.3.2.9;3.1.1.71;3.1.1.6;3.1.1.34;3.1.-.-", "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0046872 metal ion binding;GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005901 caveola", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0X804-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49339-1", "uniprot_id": "WNT11_CHICK", "mass": 39507.0, "length": 354, "protein_name": "Protein Wnt-11", "gene_name": "WNT11", "organism": "Chicken", "refseq_name": "protein Wnt-11 precursor", "refseq_ac": "NP_990115", "gene_names_uniprotkb": "WNT11; WNT-11", "gene_names_refseq": "WNT-11; WNT11", "protein_names_uniprotkb": "Protein Wnt-11", "protein_names_refseq": "Wnt-11 protein; protein Wnt-11 precursor; protein Wnt-11; wingless-type MMTV integration site family, member 11", "tax_id": 9031, "disease": "", "pathway": " (gga:395562); (R-GGA-3238698); (R-GGA-4086398)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16818447;18987628;24671096;7579581;7779076", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D31901.1, SRR13267653.13194.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D31901.1., [RefSeq]; During early chick myogenesis WNT11 has an essential role in the oriented elongation of the myocytes, [RefSeq, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters., [UniProtKB]; Wnt11 and Wnt6 act as factors maintaining the epithelial nature of the dorsomedial and ventrolateral lips of the dermomyotome, respectively, during dermomyotomal growth., [RefSeq, PubMed]; Wnt11 is required for dense dermis and subsequent cutaneous appendage formation, by influencing the cell fate decision of the cells in the dorsomedial lip. Erratum:[PLoS One. 2018 Sep 10;13(9):e0203913. doi: 10.1371/journal.pone.0203913. PMID: 30199548] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0042056 chemoattractant activity;GO:0030295 protein kinase activator activity;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZMF3-1", "uniprot_id": "DCK_CHICK", "mass": 30373.0, "length": 257, "protein_name": "Deoxycytidine kinase", "gene_name": "DCK", "organism": "Chicken", "refseq_name": "deoxycytidine kinase", "refseq_ac": "NP_001006451", "gene_names_uniprotkb": "DCK; RCJMB04_2e2", "gene_names_refseq": "DCK; GgdCK", "protein_names_uniprotkb": "Deoxycytidine kinase; 2.7.1.113; 2.7.1.74; 2.7.1.76; Deoxyadenosine kinase; Deoxyguanosine kinase; GgdCK", "protein_names_refseq": "deoxyadenosine kinase; deoxycytidine kinase; deoxyguanosine kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:422648)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;27906638", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719431.1, HAEK01059701.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1. On Nov 22, 2004 this sequence version replaced XP_420602.1., [RefSeq]; Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:27906638). Displays highest activity against deoxycytidine followed by deoxyadenosine and then deoxyguanosine (PubMed:27906638). Shows only very minor activity against deoxyuridine and deoxythymidine (PubMed:27906638)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.113;2.7.1.76;2.7.1.74", "go_molecular_function": "GO:0004138 deoxyguanosine kinase activity;GO:0005524 ATP binding;GO:0004137 deoxycytidine kinase activity;GO:0004136 deoxyadenosine kinase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0009157 deoxyribonucleoside monophosphate biosynthetic process;GO:0032261 purine nucleotide salvage", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZMF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06A37-1", "uniprot_id": "CHD7_CHICK", "mass": 338213.0, "length": 3011, "protein_name": "ATP-dependent chromatin remodeler CHD7", "gene_name": "CHD7", "organism": "Chicken", "refseq_name": "ATP-dependent chromatin remodeler CHD7", "refseq_ac": "NP_001071054", "gene_names_uniprotkb": "CHD7", "gene_names_refseq": "CHD-7; CHD7", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD7; 3.6.4.-; CHD-7; Chromo domain-containing protein 7", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD7; ATP-dependent helicase CHD7; chromo domain-containing protein 7", "tax_id": 9031, "disease": "", "pathway": " (gga:421140); (R-GGA-9943962)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17149726;32816902", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: DQ978381.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000043.1. On Dec 9, 2006 this sequence version replaced XP_419222.2., [RefSeq]; ATP-dependent chromatin-remodeling factor, slides nucleosomes along DNA; nucleosome sliding requires ATP.Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity)., [UniProtKB, UniProtKB]; CChd7 was expressed in the neural epithelium, the otic placodes, the optic placodes, the branchial arches, and the olfactory placodes, which are the primordial tissues that give rise to organs affected in human CHARGE syndrome patients., [RefSeq, PubMed]; Let-7 miRNAs inhibit CHD7 expression and control auditory-sensory progenitor cell behavior in the developing inner ear. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0021545 cranial nerve development;GO:0043584 nose development;GO:0048806 genitalia development;GO:0060123 regulation of growth hormone secretion;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q06A37-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJR8-1", "uniprot_id": "ELOV6_CHICK", "mass": 31268.0, "length": 265, "protein_name": "Very long chain fatty acid elongase 6", "gene_name": "ELOVL6", "organism": "Chicken", "refseq_name": "very long chain fatty acid elongase 6", "refseq_ac": "NP_001026710", "gene_names_uniprotkb": "ELOVL6; RCJMB04_16d24", "gene_names_refseq": "ELOVL6", "protein_names_uniprotkb": "Very long chain fatty acid elongase 6; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL6; ELOVL FA elongase 6; ELOVL fatty acid elongase 6; Elongation of very long chain fatty acids protein 6; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6", "protein_names_refseq": "3-keto acyl-CoA synthase ELOVL6; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast); elongation of very long chain fatty acids family member protein 6; elongation of very long chain fatty acids protein 6; very long chain 3-ketoacyl-CoA synthase 6; very long chain 3-oxoacyl-CoA synthase 6; very long chain fatty acid elongase 6", "tax_id": 9031, "disease": "", "pathway": " (gga:428772)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;32120850", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720366.1, SRR13267649.176987.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Aug 8, 2005 this sequence version replaced XP_426328.1., [RefSeq]; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP, UniProtKB]; Estrogen Abolishes the Repression Role of gga-miR-221-5p Targeting ELOVL6 and SQLE to Promote Lipid Synthesis in Chicken Liver. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane;GO:0009923 fatty acid elongase complex", "go_biological_process": "GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0042759 long-chain fatty acid biosynthetic process;GO:0019367 fatty acid elongation, saturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZJR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02112-1", "uniprot_id": "HBB_CHICK", "mass": 16466.0, "length": 147, "protein_name": "Hemoglobin subunit beta", "gene_name": "HBBA; HBB", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HBBA; HBB", "gene_names_refseq": "", "protein_names_uniprotkb": "Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396485); (R-GGA-1237044); (R-GGA-1247673); (R-GGA-2168880); (R-GGA-6798695); (R-GGA-9707564); (R-GGA-9707616)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "10037733;514809;6263308;6266925;6833240;773926;8307571", "class_list": "", "function": "Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90594;Q90863;Q90938", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030492 hemoglobin binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P02112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67881-1", "uniprot_id": "CYC_CHICK", "mass": 11711.0, "length": 105, "protein_name": "Cytochrome c", "gene_name": "CYCS; CYC", "organism": "Chicken", "refseq_name": "cytochrome c", "refseq_ac": "NP_001072946", "gene_names_uniprotkb": "CYCS; CYC", "gene_names_refseq": "CYCS; CYC", "protein_names_uniprotkb": "Cytochrome c", "protein_names_refseq": "cytochrome c", "tax_id": 9031, "disease": "", "pathway": " (gga:420624); (R-GGA-111457); (R-GGA-111458); (R-GGA-111459); (R-GGA-111461); (R-GGA-2151201); (R-GGA-3299685); (R-GGA-5620971); (R-GGA-5628897); (R-GGA-611105); (R-GGA-9627069); (R-GGA-9707564)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "5903744;6324108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01003184.1, HAEL01000396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On or before Dec 14, 2021 this sequence version replaced XP_015136937.1, XP_418723.2, XP_001234819.1, XP_001234828.1., [RefSeq]; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00016;Q9PRU4", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P67881-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48800-1", "uniprot_id": "FGF2_CHICK", "mass": 17374.0, "length": 158, "protein_name": "Fibroblast growth factor 2", "gene_name": "FGF2", "organism": "Chicken", "refseq_name": "fibroblast growth factor 2", "refseq_ac": "NP_990764", "gene_names_uniprotkb": "FGF2", "gene_names_refseq": "BFGF; FGF-2; FGF2; HBGF-2", "protein_names_uniprotkb": "Fibroblast growth factor 2; Basic fibroblast growth factor; FGF-2; HBGF-2; Heparin-binding growth factor 2; bFGF", "protein_names_refseq": "basic fibroblast growth factor; fibroblast growth factor 2 (basic); fibroblast growth factor 2; heparin-binding growth factor 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396413); (R-GGA-109704); (R-GGA-1257604); (R-GGA-190322); (R-GGA-190370); (R-GGA-190372); (R-GGA-190373); (R-GGA-190375); (R-GGA-190377); (R-GGA-3000170); (R-GGA-5654219); (R-GGA-5654221); (R-GGA-5654227); (R-GGA-5654228); (R-GGA-5654687); (R-GGA-5654688); (R-GGA-5654689); (R-GGA-5654693); (R-GGA-5654695); (R-GGA-5654699); (R-GGA-5654700); (R-GGA-5654704); (R-GGA-5654706); (R-GGA-5654710); (R-GGA-5654712); (R-GGA-5654719); (R-GGA-5654720); (R-GGA-5654726); (R-GGA-5654727); (R-GGA-5654732); (R-GGA-5654733); (R-GGA-5658623); (R-GGA-5673001); (R-GGA-6811558); (R-GGA-9839397)", "pathway_count": 35, "publication_count": 5, "publication_id_list": "26719333;26865366;27070743;34555602;7683281", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BI391135.1, M95707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992604, SAMN06140853 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity)., [UniProtKB, UniProtKB]; BFGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons. Publication Status: Online-Only, [RefSeq, PubMed]; Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf., [RefSeq, PubMed]; LIF and bFGF enhanced chicken primordial follicle activation by Wnt/beta-catenin pathway., [RefSeq, PubMed]; Synthesis increased in embryonic ventricular cardiomyocytes in response to increased stretch due to pressure overload, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding;GO:0042056 chemoattractant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0001525 angiogenesis;GO:0003407 neural retina development;GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48800-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42324-1", "uniprot_id": "HPCL1_CHICK", "mass": 22269.0, "length": 193, "protein_name": "Hippocalcin-like protein 1", "gene_name": "HPCAL1", "organism": "Chicken", "refseq_name": "hippocalcin-like protein 1", "refseq_ac": "NP_990565", "gene_names_uniprotkb": "HPCAL1; REM1", "gene_names_refseq": "HPCAL1; REM-1; REM1", "protein_names_uniprotkb": "Hippocalcin-like protein 1; Protein Rem-1", "protein_names_refseq": "hippocalcin-like protein 1; protein Rem-1", "tax_id": 9031, "disease": "", "pathway": " (gga:396161)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7700627", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X80875.1, HAEK01015002.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000066.1. On Aug 30, 2004 this sequence version replaced XP_429292.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P42324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09324-1", "uniprot_id": "YES_CHICK", "mass": 60792.0, "length": 541, "protein_name": "Tyrosine-protein kinase Yes", "gene_name": "YES1", "organism": "Chicken", "refseq_name": "tyrosine-protein kinase Yes", "refseq_ac": "NP_990632", "gene_names_uniprotkb": "YES1; YES", "gene_names_refseq": "YES1; YES", "protein_names_uniprotkb": "Tyrosine-protein kinase Yes; 2.7.10.2; p61-Yes", "protein_names_refseq": "p61-Yes; proto-oncogene tyrosine-protein kinase YES; tyrosine-protein kinase Yes; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396238); (R-GGA-1227986); (R-GGA-1433557); (R-GGA-1433559); (R-GGA-210990); (R-GGA-389356); (R-GGA-389513); (R-GGA-3928662); (R-GGA-3928663); (R-GGA-3928665); (R-GGA-912631)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "1281306;2464785;3054816;8035999", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X12461.1, SRR13267658.11813.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000043.1., [RefSeq]; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;3.6.5.2;2.3.2.27;2.7.11.1;2.7.1.153;2.7.1.137;2.7.10.4;3.1.3.48", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XY15-1", "uniprot_id": "A0A8V0XY15_CHICK", "mass": 36099.0, "length": 330, "protein_name": "Prostaglandin reductase 1", "gene_name": "PTGR1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PTGR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostaglandin reductase 1; 1.3.1.48; 1.3.1.74; 15-oxoprostaglandin 13-reductase; Dithiolethione-inducible gene 1 protein; Leukotriene B4 12-hydroxydehydrogenase; NAD(P)H-dependent alkenal/one oxidoreductase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.3.1.74;1.3.1.48", "go_molecular_function": "GO:0032440 2-alkenal reductase [NAD(P)H] activity;GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity;GO:0035798 2-alkenal reductase (NADPH) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006693 prostaglandin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XY15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O73888-1", "uniprot_id": "HPGDS_CHICK", "mass": 22730.0, "length": 199, "protein_name": "Hematopoietic prostaglandin D synthase", "gene_name": "HPGDS", "organism": "Chicken", "refseq_name": "hematopoietic prostaglandin D synthase", "refseq_ac": "NP_990342", "gene_names_uniprotkb": "HPGDS; GSTS; PGDS; PTGDS2", "gene_names_refseq": "GSTS; H-PGDS; HPGDS; PGDS; PTGDS2", "protein_names_uniprotkb": "Hematopoietic prostaglandin D synthase; 2.5.1.18; 5.3.99.2; GST class-sigma; Glutathione S-transferase; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; H-PGDS; Prostaglandin-H2 D-isomerase", "protein_names_refseq": "GST class-sigma; glutathione S-transferase; glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; glutathione-requiring prostaglandin D synthase; hematopoietic prostaglandin D synthase; prostaglandin-D synthase; prostaglandin-H2 D-isomerase", "tax_id": 9031, "disease": "", "pathway": " (gga:395863); (R-GGA-156590); (R-GGA-2162123)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11572089;19954828;31065698;9657971", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01090482.1, HAEK01117890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992428, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000073.1., [RefSeq]; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide., [UniProtKB, PubMed]; PGDS induces LH beta transcription and subsequent translation via the Peroxisome Proliferator-Activated Receptor (PPAR) signaling pathway., [RefSeq, PubMed]; The expression of both H-PGDS and WNT2, which are involved in the prostaglandin D2 and WNT signaling pathways, respectively, was low in the testis of low sperm motility phenotype roosters., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.18;5.2.1.2;1.20.4.2;1.8.5.1;5.3.99.2", "go_molecular_function": "GO:0004667 prostaglandin-D synthase activity;GO:0004364 glutathione transferase activity;GO:0000287 magnesium ion binding;GO:0005509 calcium ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006693 prostaglandin metabolic process;GO:0001516 prostaglandin biosynthetic process;GO:0006749 glutathione metabolic process;GO:0019371 cyclooxygenase pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O73888-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NTD3-1", "uniprot_id": "F1NTD3_CHICK", "mass": 56776.0, "length": 502, "protein_name": "receptor protein serine/threonine kinase", "gene_name": "BMPR1B", "organism": "Chicken", "refseq_name": "bone morphogenetic protein receptor type-1B precursor", "refseq_ac": "NP_001384808", "gene_names_uniprotkb": "BMPR1B", "gene_names_refseq": "BMPR1B; RPK-1", "protein_names_uniprotkb": "receptor protein serine/threonine kinase; 2.7.11.30", "protein_names_refseq": "ALK-6; BMP type-1B receptor; BMPR-1B; SKR6; activin receptor-like kinase 6; bone morphogenetic protein receptor type-1B precursor; bone morphogenetic protein receptor, type IB; receptor protein kinase; serine/threonine-protein kinase receptor R6", "tax_id": 9031, "disease": "", "pathway": " (gga:396030); (R-GGA-201451)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15804571;23250207;28359351", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.302163.1, SRR13267660.9165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Dec 3, 2021 this sequence version replaced XP_015131638.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; BMP signaling via Bmpr1a and Bmpr1b, is sufficient to modify nuclear organization in the chick diencephalon, [RefSeq, PubMed]; The finding that retinal gene expression for BMP2, 4, 7 and their receptors are not affected by short-term optical defocus contrasts with previous observations of sign-dependent expression changes for the same genes in the RPE., [RefSeq, PubMed]; Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.7.11.30", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity;GO:0005025 transforming growth factor beta receptor activity, type I;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0009888 tissue development;GO:0009653 anatomical structure morphogenesis;GO:0006954 inflammatory response;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1NTD3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48143-1", "uniprot_id": "VIP_CHICK", "mass": 22540.0, "length": 200, "protein_name": "VIP peptides", "gene_name": "VIP", "organism": "Chicken", "refseq_name": "VIP peptides isoform 2 preproprotein", "refseq_ac": "NP_001170780", "gene_names_uniprotkb": "VIP", "gene_names_refseq": "VIP", "protein_names_uniprotkb": "VIP peptides; Vasoactive intestinal polypeptide", "protein_names_refseq": "VIP peptides isoform 2 preproprotein; VIP peptides", "tax_id": 9031, "disease": "", "pathway": " (gga:396323); (R-GGA-418555); (R-GGA-420092)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1227973;20461580;22184441;27021352;7890166", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X80906.1, BU132741.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440, SAMEA103992453 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Marker-trait association analyses showed that the 'AGG' indel was associated with total number of eggs from 90 to 300 d of age and total number of qualified eggs from 90 to 300 d of age; C + 338T was associated with duration of broodiness., [RefSeq, PubMed]; PHM-27 is a bioactive form from proteolysis of the same precursor protein, that causes vasodilation., [UniProtKB, UniProtKB]; Study suggests that VIP, Prl, and inhibin have an important effect on the reproductive axis in aging roosters., [RefSeq, PubMed]; VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; VIP signaling may regulate BMAL1 expression and, thus, a daily rhythmicity within granulosa cells of preovulatory follicles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01285", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding;GO:0031892 type 2 vasoactive intestinal polypeptide receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043005 neuron projection;GO:0005615 extracellular space", "go_biological_process": "GO:0048242 epinephrine secretion;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0048255 mRNA stabilization;GO:0032880 regulation of protein localization;GO:0070459 prolactin secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P48143-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17153-1", "uniprot_id": "ANXA5_CHICK", "mass": 36198.0, "length": 321, "protein_name": "Annexin A5", "gene_name": "ANXA5", "organism": "Chicken", "refseq_name": "annexin A5", "refseq_ac": "NP_001026709", "gene_names_uniprotkb": "ANXA5; ANX5", "gene_names_refseq": "ANX5; ANXA5; CBP-I; CPB-I; PAP-I", "protein_names_uniprotkb": "Annexin A5; Anchorin CII; Annexin V; Annexin-5; CPB-I; Calphobindin I; Endonexin II; Lipocortin V; PAP-I; Placental anticoagulant protein I; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha", "protein_names_refseq": "VAC-alpha; anchorin CII; annexin A5; annexin V; annexin-5; calphobindin I; endonexin II; lipocortin V; placental anticoagulant protein I; thromboplastin inhibitor; vascular anticoagulant-alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:428767); (R-GGA-114608)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "16914549;19388055;2037607;2552626;2833522;2847914;8163186;8471604;8484740", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01013402.1, HAEK01000373.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On or before Nov 5, 2021 this sequence version replaced XP_015131802.1, XP_426323.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Binding of annexin V to active PKCalpha stimulates apoptotic events in growth plate chondrocytes and binding of annexin V to beta5 integrin controls these interactions and ultimately apoptosis, [RefSeq, PubMed]; Collagen-binding protein., [UniProtKB]; Study shows annexin A5 induces aggregation of vesicles containing acidic phospholipids even at low protein and/or calcium concentration by establishment of protein dimers; experiments show ability to aggregate vesicles mainly resides in the N-terminus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031982 vesicle;GO:0042383 sarcolemma;GO:0034704 calcium channel complex;GO:0012506 vesicle membrane", "go_biological_process": "GO:0055074 calcium ion homeostasis;GO:0050819 negative regulation of coagulation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P17153-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23991-1", "uniprot_id": "ADH1_CHICK", "mass": 39808.0, "length": 376, "protein_name": "Alcohol dehydrogenase 1", "gene_name": "ADH1C; ADH1", "organism": "Chicken", "refseq_name": "alcohol dehydrogenase 1", "refseq_ac": "NP_001292112", "gene_names_uniprotkb": "ADH1C; ADH1", "gene_names_refseq": "ADH-1; ADH1B; ADH1C; ADH1", "protein_names_uniprotkb": "Alcohol dehydrogenase 1; 1.1.1.1; ADH-1; Alcohol dehydrogenase I", "protein_names_refseq": "alcohol dehydrogenase 1B (class I), beta polypeptide; alcohol dehydrogenase 1; alcohol dehydrogenase I", "tax_id": 9031, "disease": "", "pathway": " (gga:771920); (R-GGA-211935); (R-GGA-2161541); (R-GGA-5365859); (R-GGA-71384)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "2269284;2387402", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888524.101550.1, SRR12888531.75611.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Feb 27, 2015 this sequence version replaced XP_001234263.3. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0004022 alcohol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P23991-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46158-1", "uniprot_id": "GLL2_CHICK", "mass": 7142.0, "length": 64, "protein_name": "Gallinacin-2", "gene_name": "DEFB4A; GAL2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DEFB4A; GAL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Gallinacin-2; Beta-defensin 2; Gal-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395840); (R-GGA-1461957); (R-GGA-1461973)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15148642;15310403;16394622;17244739;19151352;22205704;8150085;9745666", "class_list": "", "function": "Potent antibacterial activity against the Gram-negative bacterium E.coli ML-35, and against the Gram-positive bacterium L.monocytogenes EGD. Lacks antifungal activity against C.albicans., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q09MT0;Q0PWH3;Q6B9W8;Q6GXJ3", "ec_number_list": "", "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0005576 extracellular region", "go_biological_process": "GO:0006952 defense response;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46158-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33150-1", "uniprot_id": "CAD13_CHICK", "mass": 78381.0, "length": 712, "protein_name": "Cadherin-13", "gene_name": "CDH13", "organism": "Chicken", "refseq_name": "cadherin-13 isoform 2 precursor", "refseq_ac": "NP_001383215", "gene_names_uniprotkb": "CDH13", "gene_names_refseq": "CDH13; cadherin-13", "protein_names_uniprotkb": "Cadherin-13; T-cadherin; T-cad; Truncated cadherin", "protein_names_refseq": "T-cadherin; cadherin 13, H-cadherin (heart); cadherin-13 isoform 2 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:414849); (R-GGA-418990)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1400585;1654948;20190755;23550144;8315665", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M81779.1, SRR13267654.169422.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Oct 5, 2021 this sequence version replaced XP_015148010.1., [RefSeq]; A risk locus with genome-wide significance spanning the T-cadherin (CDH13) gene for resistance to C. jejuni colonization in the avian intestine, is reported. Publication Status: Online-Only, [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q91353", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0042802 identical protein binding;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P33150-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07341-1", "uniprot_id": "ALDOB_CHICK", "mass": 39296.0, "length": 364, "protein_name": "Fructose-bisphosphate aldolase B", "gene_name": "ALDOB", "organism": "Chicken", "refseq_name": "fructose-bisphosphate aldolase B", "refseq_ac": "NP_001007978", "gene_names_uniprotkb": "ALDOB", "gene_names_refseq": "ALDB; ALDOB", "protein_names_uniprotkb": "Fructose-bisphosphate aldolase B; 4.1.2.13; Liver-type aldolase", "protein_names_refseq": "aldolase B, fructose-bisphosphate; fructose-bisphosphate aldolase B; liver-type aldolase", "tax_id": 9031, "disease": "", "pathway": " (gga:427308); (R-GGA-352875); (R-GGA-352882); (R-GGA-70171); (R-GGA-70263); (R-GGA-70350)", "pathway_count": 6, "publication_count": 17, "publication_id_list": "1593633;16287166;2110163;2985560;3094011;3539098;3885220;4463937;499525;6303388;6345546;6574503;7629021;7768978;7916593;8182283;9434147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CR523513.1, HAEL01000760.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000095.1. On Oct 7, 2007 this sequence version replaced XP_424890.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.2.13", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0008092 cytoskeletal protein binding;GO:0004332 fructose-bisphosphate aldolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005815 microtubule organizing center;GO:0034451 centriolar satellite", "go_biological_process": "GO:0001889 liver development;GO:0006094 gluconeogenesis;GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P07341-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0ZM14-1", "uniprot_id": "PCD15_CHICK", "mass": 209146.0, "length": 1899, "protein_name": "Protocadherin-15", "gene_name": "PCDH15; Pcdh15", "organism": "Chicken", "refseq_name": "protocadherin-15 isoform 2 precursor", "refseq_ac": "NP_001038119", "gene_names_uniprotkb": "PCDH15; Pcdh15", "gene_names_refseq": "PCDH15; protocadherin-15", "protein_names_uniprotkb": "Protocadherin-15", "protein_names_refseq": "protocadherin 15; protocadherin-15 isoform 2 precursor; protocadherin-15-CD3", "tax_id": 9031, "disease": "", "pathway": " (gga:423644)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;16807332", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ354420.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA103992290, SAMEA103992482 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000227.1. On Dec 10, 2021 this sequence version replaced NP_001038119.1., [RefSeq]; Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1N8B3;Q0ZM04;Q0ZM05;Q0ZM06;Q0ZM07;Q0ZM08;Q0ZM09;Q0ZM10;Q0ZM11;Q0ZM12;Q0ZM13", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0001750 photoreceptor outer segment;GO:0032420 stereocilium", "go_biological_process": "GO:0007155 cell adhesion;GO:0007601 visual perception;GO:0007605 sensory perception of sound;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0ZM14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C7Z1-1", "uniprot_id": "E1C7Z1_CHICK", "mass": 94527.0, "length": 822, "protein_name": "Tyrosine-protein kinase", "gene_name": "FER", "organism": "Chicken", "refseq_name": "tyrosine-protein kinase Fer isoform X1", "refseq_ac": "XP_413981", "gene_names_uniprotkb": "FER", "gene_names_refseq": "FER", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase Fer isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1433557)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_413981.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0004713 protein tyrosine kinase activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0042995 cell projection", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1C7Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21548-1", "uniprot_id": "GBRG2_CHICK", "mass": 54970.0, "length": 474, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-2", "gene_name": "GABRG2", "organism": "Chicken", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-2 precursor", "refseq_ac": "NP_990676", "gene_names_uniprotkb": "GABRG2", "gene_names_refseq": "GABRG2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2; GABAAR subunit gamma-2", "protein_names_refseq": "GABA(A) receptor subunit gamma-2; GABA-A receptor gamma-2 subunit; GABAAR subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2 precursor; gamma-aminobutyric acid receptor subunit gamma-2", "tax_id": 9031, "disease": "", "pathway": " (gga:396289); (R-GGA-977443)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17638299;2175889", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01042269.1, HAEK01024115.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN218444.1, BU279072.1, HAEK01024115.1, JAENSK010000256.1, X54944.1, BU120526.1, CO762669.1, BU237035.1 and HAEK01001258.1. On Aug 30, 2004 this sequence version replaced XP_429299.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our results show that 1 hr of normobaric acute hypoxia significantly changes the subunit mRNA levels. Different subunit mRNAs display different sensitivity to hypoxia: alpha(1), beta(2), and gamma(2) mRNAs are highly sensitive., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0098794 postsynapse;GO:0034707 chloride channel complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0071420 cellular response to histamine;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21548-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C734-1", "uniprot_id": "E1C734_CHICK", "mass": 55107.0, "length": 501, "protein_name": "Cystine/glutamate transporter", "gene_name": "SLC7A11", "organism": "Chicken", "refseq_name": "cystine/glutamate transporter isoform X1", "refseq_ac": "XP_426289", "gene_names_uniprotkb": "SLC7A11", "gene_names_refseq": "SLC7A11", "protein_names_uniprotkb": "Cystine/glutamate transporter; Amino acid transport system xc-; Solute carrier family 7 member 11; xCT", "protein_names_refseq": "cystine/glutamate transporter isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_426289.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0015327 cystine:glutamate antiporter activity;GO:0015252 proton channel activity;GO:0022840 leak channel activity", "go_cellular_component": "GO:0031528 microvillus membrane;GO:0009986 cell surface;GO:0097449 astrocyte projection;GO:0005765 lysosomal membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0015811 L-cystine transport;GO:0043067 regulation of programmed cell death;GO:0015813 L-glutamate transmembrane transport;GO:0009636 response to toxic substance;GO:0035752 lysosomal lumen pH elevation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1C734-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07583-1", "uniprot_id": "LEG4_CHICK", "mass": 15063.0, "length": 135, "protein_name": "Beta-galactoside-binding lectin", "gene_name": "CG-1B; LGALS1A", "organism": "Chicken", "refseq_name": "beta-galactoside-binding lectin", "refseq_ac": "NP_990826", "gene_names_uniprotkb": "CG-1B; LGALS1A", "gene_names_refseq": "CG-1B; LGALS1A; LGALS1", "protein_names_uniprotkb": "Beta-galactoside-binding lectin; 14 kDa lectin; C-14; Galectin CG-1B", "protein_names_refseq": "14 kDa lectin; 14K beta-galactoside-binding lectin; C-14; beta-galactoside-binding lectin; galectin CG-1B; gbl; lectin, galactoside-binding, soluble, 1 (galectin 1)", "tax_id": 9031, "disease": "", "pathway": " (gga:396491)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18848566;22022970;22884463;27268118;28978647;3004444;3182759;3597352", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CO503046.1, HAEK01124082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992527, SAMN02738216 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Chicken alectins 1 and galectins 2 promote influenza virus binding in dose dependent manner., [RefSeq, PubMed]; Data indicate that the diffusion constant of avian galectin-1 (CG-1B) increased by 5.6% in the presence of lactose, as has been seen for the human galectin-1., [RefSeq, PubMed]; Galectin-1B has anti-Newcastle disease virus activity by binding to N-glycans on hemagglutinin-neuraminidase glycoprotein., [RefSeq, PubMed]; This protein binds beta-galactoside. May participate in host antiviral defense through specific interaction with glycans on the viral envelope glycoproteins., [UniProtKB, PubMed]; Vertebrates have a highly conserved gene for galectin-1-related protein.It is the sixth protein of this family in chicken, a model for network analysis.It lacks canonical capacity to bind lactose.Its crystal structure explains this loss of activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043236 laminin binding;GO:0030395 lactose binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P07583-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O73790-1", "uniprot_id": "SPB10_CHICK", "mass": 47384.0, "length": 410, "protein_name": "Heterochromatin-associated protein MENT", "gene_name": "SERPINB10B; SERPINB10", "organism": "Chicken", "refseq_name": "heterochromatin-associated protein MENT", "refseq_ac": "NP_990228", "gene_names_uniprotkb": "SERPINB10B; SERPINB10; MENT", "gene_names_refseq": "MENT-1; MENT; SERPINB10B; SERPINB10", "protein_names_uniprotkb": "Heterochromatin-associated protein MENT; Myeloid and erythroid nuclear termination stage-specific protein; Serpin B10", "protein_names_refseq": "heterochromatin-associated protein MENT; myeloid and erythroid nuclear termination stage-specific protein; serpin B10; serpin family B member 10", "tax_id": 9031, "disease": "", "pathway": " (gga:395715)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10026180;11821386;12930828;16810322;19266095;21656257;9446625", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF053401.1, SRR12888544.491155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992527 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000040.1., [RefSeq]; DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Data show that a promotion of chromatin folding in terminally differentiated avian blood cells requires the presence of either histone H5 in erythrocytes or myeloid and erythroid nuclear termination stage-specific protein (MENT) in white blood cells. Review article, [RefSeq, PubMed]; MENT was found to undergo structural shifts in the presence of DNA packaged into nucleosomes, but not naked DNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005634 nucleus", "go_biological_process": "GO:0006325 chromatin organization;GO:0030261 chromosome condensation;GO:0043362 nucleate erythrocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O73790-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q11200-1", "uniprot_id": "SIA4A_CHICK", "mass": 39540.0, "length": 342, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1", "gene_name": "ST3GAL1", "organism": "Chicken", "refseq_name": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1", "refseq_ac": "NP_990548", "gene_names_uniprotkb": "ST3GAL1; SIAT4A", "gene_names_refseq": "SIAT4A; ST3GAL1", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; 2.4.3.4; Alpha 2,3-ST 1; Beta-galactoside alpha-2,3-sialyltransferase 1; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; SIAT4-A; ST3Gal I; ST3GalA.1; ST3GalI; ST3O; Sialyltransferase 4A", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1; SIAT4-A; ST3Gal I; ST3GalA.1; ST3GalI; ST3O; alpha 2,3-ST 1; beta-galactoside alpha-2,3-sialyltransferase 1; gal-NAc6S; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; sialyltransferase 4A", "tax_id": 9031, "disease": "", "pathway": " (gga:396140); (R-GGA-2022854); (R-GGA-4085001); (R-GGA-977068)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "27150510;7766661", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X80503.1, JX035875.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992683 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X80503.1., [RefSeq]; Analyses of chicken sialyltransferases related to O-glycosylation, including their molecular cloning, substrate specificity and tissue distribution, [RefSeq, PubMed]; Responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.3.6;2.4.3.9;2.4.3.2;2.4.3.4", "go_molecular_function": "GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0032580 Golgi cisterna membrane;GO:0032588 trans-Golgi network membrane;GO:1990675 Golgi medial cisterna membrane", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0006487 protein N-linked glycosylation;GO:0097503 sialylation;GO:0009101 glycoprotein biosynthetic process;GO:1905403 negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q11200-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y9P9-1", "uniprot_id": "A0A8V0Y9P9_CHICK", "mass": 62416.0, "length": 569, "protein_name": "Aldehyde dehydrogenase 9 family member A1", "gene_name": "ALDH9A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ALDH9A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldehyde dehydrogenase 9 family member A1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-71262)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.1.3;1.2.1.31;1.2.1.8;1.2.1.36;1.2.1.19;1.2.1.28", "go_molecular_function": "GO:0018467 formaldehyde dehydrogenase (NAD+) activity;GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity;GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006081 aldehyde metabolic process;GO:0042429 serotonin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y9P9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50223-1", "uniprot_id": "HMGX7_CHICK", "mass": 30517.0, "length": 288, "protein_name": "Homeobox protein GHOX-7", "gene_name": "GHOX-7; MSX1", "organism": "Chicken", "refseq_name": "homeobox protein MSX-1", "refseq_ac": "NP_990819", "gene_names_uniprotkb": "GHOX-7; MSX1", "gene_names_refseq": "CHOX-7; GHOX-7; HOX-7; MSX1", "protein_names_uniprotkb": "Homeobox protein GHOX-7; CHOX-7; Hox-7", "protein_names_refseq": "Hbox 7; homeobox protein GHOX-7; homeobox protein Hox-7; homeobox protein MSX-1; msh homeo box homolog 1; msh homeobox 1-like protein; msh homeobox homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396484)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1346246;1350765;1684333;33191650", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D10372.1, SRR13267654.237058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Aug 30, 2004 this sequence version replaced XP_444660.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Msx1 upregulates p27 expression to control cellular proliferation during valvuloseptal endocardial cushion formation in the chick embryonic heart., [RefSeq, PubMed]; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0043584 nose development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000902 cell morphogenesis;GO:0050821 protein stabilization;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50223-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NGX6-1", "uniprot_id": "F1NGX6_CHICK", "mass": 54892.0, "length": 483, "protein_name": "E3 ubiquitin-protein ligase Mdm2", "gene_name": "MDM2", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase Mdm2", "refseq_ac": "NP_001186313", "gene_names_uniprotkb": "MDM2", "gene_names_refseq": "MDM2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Mdm2; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase Mdm2; MDM2 oncogene, E3 ubiquitin protein ligase; MDM2 proto-oncogene, E3 ubiquitin protein ligase; Mdm2, p53 E3 ubiquitin protein ligase homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:395609); (R-GGA-198323); (R-GGA-3232142); (R-GGA-5689880); (R-GGA-6804756); (R-GGA-6804757); (R-GGA-6804760); (R-GGA-69541); (R-GGA-8941858); (R-GGA-9766229)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "23155027", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF005045.1, SRR13267659.302707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Dec 8, 2010 this sequence version replaced XP_416084.2. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; The cell cycle-related gene MDM2 showed higher expression in the cultured chicken embryonic fibroblast cells than that of cultured chicken primordial germ cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;3.4.19.12;3.1.3.67;3.1.3.16;3.1.3.48;2.7.11.22;2.3.2.27;2.3.2.-;2.7.12.1", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0043021 ribonucleoprotein complex binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051726 regulation of cell cycle;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045931 positive regulation of mitotic cell cycle;GO:1990000 amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1NGX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NTQ2-1", "uniprot_id": "F1NTQ2_CHICK", "mass": 63008.0, "length": 558, "protein_name": "Beta-hexosaminidase", "gene_name": "HEXB", "organism": "Chicken", "refseq_name": "beta-hexosaminidase subunit beta", "refseq_ac": "XP_424791", "gene_names_uniprotkb": "HEXB", "gene_names_refseq": "HEXB", "protein_names_uniprotkb": "Beta-hexosaminidase; 3.2.1.52", "protein_names_refseq": "beta-hexosaminidase subunit beta", "tax_id": 9031, "disease": "", "pathway": " (gga:427204); (R-GGA-2022857); (R-GGA-2024101); (R-GGA-2160916); (R-GGA-6798695); (R-GGA-9840310)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_424791.2. COMPLETENESS: full length., [RefSeq]; Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.6.4;3.4.21.4;2.3.3.8;2.7.11.13;3.2.1.31;3.4.19.9;3.4.14.1;3.1.6.8;6.3.4.21;5.3.4.1;3.6.4.6;1.11.1.27;3.2.1.51;3.2.1.-;2.7.10.2;3.2.1.23;3.2.1.52;1.6.5.5;2.7.11.24;3.4.14.2;5.3.99.3;2.4.1.1;3.1.6.14;3.5.4.4;3.5.1.26;3.2.1.17;3.1.27.-", "go_molecular_function": "GO:0004563 beta-N-acetylhexosaminidase activity;GO:0042802 identical protein binding;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0060473 cortical granule;GO:0005615 extracellular space;GO:0016020 membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process;GO:1901135 carbohydrate derivative metabolic process;GO:0006689 ganglioside catabolic process;GO:0030209 dermatan sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NTQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11722-1", "uniprot_id": "FINC_CHICK", "mass": 273248.0, "length": 2483, "protein_name": "Fibronectin", "gene_name": "FN1", "organism": "Chicken", "refseq_name": "fibronectin precursor", "refseq_ac": "NP_001185641", "gene_names_uniprotkb": "FN1", "gene_names_refseq": "FN1; FN", "protein_names_uniprotkb": "Fibronectin; FN", "protein_names_refseq": "fibronectin precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396133); (R-GGA-114608); (R-GGA-1474228); (R-GGA-1566977); (R-GGA-202733); (R-GGA-2129379); (R-GGA-216083); (R-GGA-3000170); (R-GGA-3000178); (R-GGA-354192); (R-GGA-354194); (R-GGA-372708); (R-GGA-381426); (R-GGA-5674135); (R-GGA-8957275); (R-GGA-9634597); (R-GGA-9860927)", "pathway_count": 17, "publication_count": 8, "publication_id_list": "14681936;15592404;26845241;2823899;2830487;36834965;6572007;8603103", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000235.1. On Nov 10, 2010 this sequence version replaced XP_421868.2. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record are predicted based on chicken transcript alignments and on homologous protein alignments with human NP_002017.1 and mouse NP_002017.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Fibronectin is produced by radial glia and is aligned along their surfaces before and during migration, [RefSeq, PubMed]; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 8, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "F1NJT3;Q90921", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0003677 DNA binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0016504 peptidase activator activity", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:0051702 biological process involved in interaction with symbiont;GO:0048484 enteric nervous system development;GO:0007044 cell-substrate junction assembly;GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P11722-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32882-1", "uniprot_id": "TBB2_CHICK", "mass": 49953.0, "length": 445, "protein_name": "Tubulin beta-2 chain", "gene_name": "TUBB2B", "organism": "Chicken", "refseq_name": "tubulin beta-2 chain", "refseq_ac": "NP_001004400", "gene_names_uniprotkb": "TUBB2B", "gene_names_refseq": "TUBB2B; TUBB2", "protein_names_uniprotkb": "Tubulin beta-2 chain; Beta-tubulin class-II", "protein_names_refseq": "Beta-tubulin class-I; Tubulin beta-1 chain; beta-tubulin class-II; tubulin beta-2 chain", "tax_id": 9031, "disease": "", "pathway": " (gga:420883)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3837190;7464932", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000076.1, HAEL01000034.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000040.1. On Sep 17, 2004 this sequence version replaced XP_418970.1., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02555", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0005509 calcium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001764 neuron migration;GO:0000226 microtubule cytoskeleton organization;GO:0031115 negative regulation of microtubule polymerization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P32882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZIU3-1", "uniprot_id": "DYRK2_CHICK", "mass": 59437.0, "length": 526, "protein_name": "Dual specificity tyrosine-phosphorylation-regulated kinase 2", "gene_name": "DYRK2", "organism": "Chicken", "refseq_name": "dual specificity tyrosine-phosphorylation-regulated kinase 2", "refseq_ac": "NP_001026651", "gene_names_uniprotkb": "DYRK2; RCJMB04_23i19", "gene_names_refseq": "DYRK2", "protein_names_uniprotkb": "Dual specificity tyrosine-phosphorylation-regulated kinase 2; 2.7.12.1", "protein_names_refseq": "dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:427864); (R-GGA-6804756)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720691.1, AJ744651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Aug 8, 2005 this sequence version replaced XP_425438.1., [RefSeq]; Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.10.2;2.7.10.1;2.7.11.22;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.3.2.27;2.7.10.4;2.7.11.11", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0032991 protein-containing complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045725 positive regulation of glycogen biosynthetic process;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07630-1", "uniprot_id": "CAH2_CHICK", "mass": 29008.0, "length": 260, "protein_name": "Carbonic anhydrase 2", "gene_name": "CA2", "organism": "Chicken", "refseq_name": "carbonic anhydrase 2", "refseq_ac": "NP_990648", "gene_names_uniprotkb": "CA2", "gene_names_refseq": "CA2", "protein_names_uniprotkb": "Carbonic anhydrase 2; 4.2.1.1; 4.2.1.69; CA-II; Carbonate dehydratase II; Carbonic anhydrase II; Cyanamide hydratase CA2", "protein_names_refseq": "CA-II; carbonate dehydratase II; carbonic anhydrase 2; carbonic anhydrase II; cyanamide hydratase CA2", "tax_id": 9031, "disease": "", "pathway": " (gga:396257); (R-GGA-1237044); (R-GGA-1247673); (R-GGA-1475029)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1969140;21375785;3029691;3102231;32828393;6331256;7926806", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN210867.1, HAEL01000057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the reversible hydration of carbon dioxide. Can also hydrate cyanamide to urea., [UniProtKB, UniProtKB]; Developmental changes and sexual differences of CA-II concentration in WL-chicken erythrocytes were observed Publication Status: Online-Only, [RefSeq, PubMed]; Effects in broiler hens of genetic lines differing in fertility, biotin supplementation, and age on relative abundance of oviductal transforming growth factor-beta and carbonic anhydrase mRNA transcripts., [RefSeq, PubMed]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity;GO:0004064 arylesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0005829 cytosol", "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0051453 regulation of intracellular pH;GO:0071244 cellular response to carbon dioxide;GO:0038166 angiotensin-activated signaling pathway;GO:0044070 regulation of monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P07630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19596-1", "uniprot_id": "FGF1_CHICK", "mass": 17322.0, "length": 155, "protein_name": "Fibroblast growth factor 1", "gene_name": "FGF1", "organism": "Chicken", "refseq_name": "fibroblast growth factor 1", "refseq_ac": "NP_990511", "gene_names_uniprotkb": "FGF1", "gene_names_refseq": "ECGF; FGF-1; FGF1", "protein_names_uniprotkb": "Fibroblast growth factor 1; Acidic fibroblast growth factor; ECGF; Endothelial cell growth factor; FGF-1; HBGF-1; Heparin-binding growth factor 1; aFGF", "protein_names_refseq": "HBGF-1; acidic fibroblast growth factor, aFGF; alpha-endothelial cell growth factor; fibroblast growth factor 1 (acidic); fibroblast growth factor 1; heparin-binding growth factor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396094); (R-GGA-109704); (R-GGA-1257604); (R-GGA-190322); (R-GGA-190370); (R-GGA-190371); (R-GGA-190372); (R-GGA-190373); (R-GGA-190375); (R-GGA-190377); (R-GGA-5654219); (R-GGA-5654221); (R-GGA-5654227); (R-GGA-5654228); (R-GGA-5654687); (R-GGA-5654688); (R-GGA-5654689); (R-GGA-5654693); (R-GGA-5654695); (R-GGA-5654699); (R-GGA-5654700); (R-GGA-5654704); (R-GGA-5654706); (R-GGA-5654710); (R-GGA-5654712); (R-GGA-5654719); (R-GGA-5654720); (R-GGA-5654726); (R-GGA-5654727); (R-GGA-5654732); (R-GGA-5654733); (R-GGA-5673001); (R-GGA-6811558)", "pathway_count": 33, "publication_count": 6, "publication_id_list": "15517595;1715259;22411638;22995917;30259763;3402441", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01059830.1, S63263.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992470, SAMN05341171 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; FGF signaling regulates gene expression by negatively modulating microRNA abundance through both LIN28B-dependent and LIN28B-independent pathways, [RefSeq, PubMed]; FGF-1-stimulated angiogenesis in vivo in influenced by PKB/AKT signaling, [RefSeq, PubMed]; Fibroblast growth factor and bone morphogenetic protein signaling are required for specifying prechondrogenic identity in neural crest-derived mesenchyme and initiating the chondrogenic program., [RefSeq, PubMed]; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results provide a basis for functional elucidation of fibroblast growth factor 1 and fibroblast growth factor 10 genes on adipocyte development and intramuscular fat deposition, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0044548 S100 protein binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P19596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P83038-1", "uniprot_id": "HDAC4_CHICK", "mass": 119468.0, "length": 1080, "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "organism": "Chicken", "refseq_name": "histone deacetylase 4", "refseq_ac": "NP_989644", "gene_names_uniprotkb": "HDAC4", "gene_names_refseq": "HDAC4", "protein_names_uniprotkb": "Histone deacetylase 4; 3.5.1.98; HD4", "protein_names_refseq": "HD4; histone deacetylase 4; osteoblast regulatory factor 3A", "tax_id": 9031, "disease": "", "pathway": " (gga:374207); (R-GGA-350054); (R-GGA-4090294); (R-GGA-4551638); (R-GGA-8951936)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22442139", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB052839.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000235.1., [RefSeq]; Findings indicate that HDAC4 nuclear-cytoplasmic shuttling controls chondrocyte differentiation in the growth plate, which is dependent on the Ca2 /calmodulin signaling pathway, [RefSeq, PubMed]; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.98;3.5.1.-;2.3.2.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004407 histone deacetylase activity;GO:0140297 DNA-binding transcription factor binding;GO:0141221 histone deacetylase activity, hydrolytic mechanism;GO:0003677 DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000118 histone deacetylase complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0007399 nervous system development;GO:0042113 B cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83038-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05199-1", "uniprot_id": "NRG1_CHICK", "mass": 67454.0, "length": 602, "protein_name": "Pro-neuregulin-1, membrane-bound isoform", "gene_name": "NRG1", "organism": "Chicken", "refseq_name": "pro-neuregulin-1, membrane-bound isoform", "refseq_ac": "NP_989448", "gene_names_uniprotkb": "NRG1; ARIA", "gene_names_refseq": "NRG1; pro-neuregulin-1", "protein_names_uniprotkb": "Pro-neuregulin-1, membrane-bound isoform; ARIA; Acetylcholine receptor-inducing activity; Pro-NRG1", "protein_names_refseq": "pro-NRG1; pro-neuregulin-1, membrane-bound isoform", "tax_id": 9031, "disease": "", "pathway": " (gga:373906); (R-GGA-1227986); (R-GGA-1236394); (R-GGA-1250196); (R-GGA-1250342); (R-GGA-1250347); (R-GGA-1257604); (R-GGA-1306955); (R-GGA-1358803); (R-GGA-1963640); (R-GGA-1963642); (R-GGA-5673001); (R-GGA-6785631); (R-GGA-6811558); (R-GGA-8863795)", "pathway_count": 15, "publication_count": 7, "publication_id_list": "15276157;19648576;24803543;28245533;29516589;8453670;9491987", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF045654.1, SRR13267656.1684.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000095.1., [RefSeq]; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses (PubMed:8453670, PubMed:9491987). Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Expression of NRG1 was studied in embryos and chicks. NRG1 in spinal motor neurons is developmentally regulated and depends on the maintenance of nerve-muscle interactions., [RefSeq, PubMed]; Findings implicate that PKC delta isoform as an important factor for the cleavage and neurotrophin-regulated release of soluble NRG1 forms that have important effects in nervous system development and disease., [RefSeq, PubMed]; Matrix interactions between exogenously supplied agrin and neuregulin-1 on the muscle surface provide a localized source of signaling factors needed to produce high densities of AChRs at neuromuscular junctions., [RefSeq, PubMed]; Trophic factor NRG1 is a chemoattractant through in vitro chemotaxis assays and in vivo silencing via a DN-erbB receptor, [RefSeq, PubMed]; While NRG1 may not be critical for overall development, it appears to be important in fine-tuning pre-, post-, and perisynaptic development of the NMJ, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O73750;O73751;O73752", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0030296 protein tyrosine kinase activator activity;GO:0008083 growth factor activity;GO:0045499 chemorepellent activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0060379 cardiac muscle cell myoblast differentiation;GO:0038127 ERBB signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q05199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05437-1", "uniprot_id": "PRRX1_CHICK", "mass": 27201.0, "length": 245, "protein_name": "Paired mesoderm homeobox protein 1", "gene_name": "PRRX1", "organism": "Chicken", "refseq_name": "paired mesoderm homeobox protein 1", "refseq_ac": "NP_001264653", "gene_names_uniprotkb": "PRRX1; MHOX; PMX1; PRX1", "gene_names_refseq": "MHOX; PMX1; PRRX1; Prx-1; Prx1; gMHox", "protein_names_uniprotkb": "Paired mesoderm homeobox protein 1; GMHOX; Homeobox protein MHOX; PRX-1; Paired-related homeobox protein 1", "protein_names_refseq": "homeobox protein MHOX; paired mesoderm homeobox protein 1; paired-related homeobox protein 1; paired-related homeotic gene product; transcription factor Prx1b", "tax_id": 9031, "disease": "", "pathway": " (gga:373941)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11036080;18942149;7577675;7906232;8101172", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01007439.1, SRR13267655.53462.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000237.1. On Jan 10, 2018 this sequence version replaced NP_001007822.1., [RefSeq]; May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face., [UniProtKB]; Signaling pathways regulating the expression of Prx1 and Prx2 in the chick mandibular mesenchyme., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91368", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q05437-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C1H3-1", "uniprot_id": "H2B1_CHICK", "mass": 13922.0, "length": 126, "protein_name": "Histone H2B 1/2/3/4/6", "gene_name": "H2B-III; H2B-II; H2B-IV; H2B-I; H2B-VI", "organism": "Chicken", "refseq_name": "histone H2B 7", "refseq_ac": "NP_001073188", "gene_names_uniprotkb": "H2B-III; H2B-II; H2B-IV; H2B-I; H2B-VI", "gene_names_refseq": "2B-VI; H2B-III; H2B-II; H2B-IV; H2B-I; H2B-VII; H2B-VI; H2BC36; HIST1H2B7", "protein_names_uniprotkb": "Histone H2B 1/2/3/4/6; H2B III; H2B II; H2B IV; H2B I; H2B VI", "protein_names_refseq": "H2B III; H2B II; H2B IV; H2B I; H2B VII; H2B VI; histone H2B 1/2/3/4/6; histone H2B 7; histone cluster 1, H2B-VII (similar to human histone cluster 1, class H2B, member N)", "tax_id": 9031, "disease": "", "pathway": " (gga:100858607); (gga:417956); (gga:769973); (gga:770188); (gga:770267); (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-3214847); (R-GGA-427413); (R-GGA-5250924); (R-GGA-5689880); (R-GGA-5693565); (R-GGA-5693571); (R-GGA-5693607); (R-GGA-606279); (R-GGA-68616); (R-GGA-69473); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 31, "publication_count": 13, "publication_id_list": "12757711;12865423;16389069;1946434;2016071;21811414;2713375;3267232;3822819;638193;7074112;7096326;8804862", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: HAEK01118559.1, HAEK01001147.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Dec 12, 2006 this sequence version replaced XP_416196.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed]; Data show that HS4 insulator element recruits the E3 ligase RNF20/BRE1A to mediate H2B mono-ubiquitination (H2Bub1) at this insulator., [RefSeq, PubMed]; Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02279;Q92067", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P0C1H3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1P4G3-1", "uniprot_id": "F1P4G3_CHICK", "mass": 131590.0, "length": 1206, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "HIPK2", "organism": "Chicken", "refseq_name": "homeodomain-interacting protein kinase 2 isoform X4", "refseq_ac": "XP_040514629", "gene_names_uniprotkb": "HIPK2", "gene_names_refseq": "HIPK2", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "homeodomain-interacting protein kinase 2 isoform X4", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3899300); (R-GGA-8939243)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.3.1.48;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.3.2.-;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0003713 transcription coactivator activity;GO:0004713 protein tyrosine kinase activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0016605 PML body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P4G3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25155-1", "uniprot_id": "FA10_CHICK", "mass": 53142.0, "length": 475, "protein_name": "Coagulation factor X", "gene_name": "F10", "organism": "Chicken", "refseq_name": "coagulation factor X precursor", "refseq_ac": "NP_990353", "gene_names_uniprotkb": "F10; FX", "gene_names_refseq": "F10; FX", "protein_names_uniprotkb": "Coagulation factor X; 3.4.21.6; Stuart factor; VAP; Virus-activating protease", "protein_names_refseq": "VAP; coagulation factor X precursor; factor XA light chain; stuart factor; virus activating protease", "tax_id": 9031, "disease": "", "pathway": " (gga:395876); (R-GGA-159763); (R-GGA-159782); (R-GGA-9769735); (R-GGA-9769739); (R-GGA-9769743)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "2044767;2174359", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D00844.1, HAEK01027058.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000025.1., [RefSeq]; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity). VAP cleaves the fusion proteins of Sendai virus, NDV, and influenza virus a at a specific single arginine-containing site, and plays a key role in the viral spreading in the allantoic sac., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.75;3.4.21.21;3.4.21.5;3.4.21.6", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0032008 positive regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P25155-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3C1E9-1", "uniprot_id": "ASF1_CHICK", "mass": 22969.0, "length": 204, "protein_name": "Histone chaperone ASF1", "gene_name": "ASF1A; ASF1", "organism": "Chicken", "refseq_name": "histone chaperone ASF1", "refseq_ac": "NP_001038155", "gene_names_uniprotkb": "ASF1A; ASF1", "gene_names_refseq": "ASF1A; ASF1", "protein_names_uniprotkb": "Histone chaperone ASF1; Anti-silencing function protein 1 homolog", "protein_names_refseq": "ASF1 anti-silencing function 1 homolog A; anti-silencing function 1; anti-silencing function protein 1 homolog; histone chaperone ASF1", "tax_id": 9031, "disease": "", "pathway": " (gga:723780); (R-GGA-2559584)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16537536", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01064271.1, HAEK01038609.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1., [RefSeq]; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. May also cooperate with HIRA to promote replication-independent chromatin assembly., [UniProtKB, PubMed]; The physiological role of Asf1 in DT40 cells is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0003682 chromatin binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006335 DNA replication-dependent chromatin assembly;GO:0006325 chromatin organization;GO:0031297 replication fork processing;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3C1E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47191-1", "uniprot_id": "SYT1_CHICK", "mass": 47505.0, "length": 424, "protein_name": "Synaptotagmin-1", "gene_name": "SYT1", "organism": "Chicken", "refseq_name": "synaptotagmin-1", "refseq_ac": "NP_990502", "gene_names_uniprotkb": "SYT1", "gene_names_refseq": "SYT1; synaptotagmin-1", "protein_names_uniprotkb": "Synaptotagmin-1; Synaptotagmin I; SytI; p65", "protein_names_refseq": "synaptotagmin I; synaptotagmin p65; synaptotagmin-1; sytI", "tax_id": 9031, "disease": "", "pathway": " (gga:396083); (R-GGA-181429); (R-GGA-181430); (R-GGA-212676); (R-GGA-264642); (R-GGA-8856825); (R-GGA-8856828); (R-GGA-888590)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "17183698;22589224;8365570", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: S64957.1, SRR13267658.25508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. May play a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB]; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone., [UniProtKB, UniProtKB]; Quantitative immunocytochemistry at an isolated calyx-type presynaptic terminal indicates that this complex is associated with SYT1 at the presynaptic transmitter release face but not with synaptotagmin 1 on intracellular synaptic vesicles Publication Status: Online-Only, [RefSeq, PubMed]; The data of this study indicated that syt1 regulates the formation of axonal filopodia and branches before engaging in its conventional functions at the synapse., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle;GO:0042584 chromaffin granule membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P47191-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05122-1", "uniprot_id": "KCRB_CHICK", "mass": 42871.0, "length": 381, "protein_name": "Creatine kinase B-type", "gene_name": "CKB", "organism": "Chicken", "refseq_name": "creatine kinase B-type", "refseq_ac": "NP_990641", "gene_names_uniprotkb": "CKB", "gene_names_refseq": "CKB; CPK-B", "protein_names_uniprotkb": "Creatine kinase B-type; 2.7.3.2; B-CK; CPK-B; Creatine kinase B chain; Creatine phosphokinase M-type", "protein_names_refseq": "B-CK; B-creatine kinase; alternate protein; creatine kinase B chain; creatine kinase B-type; creatine kinase, brain; creatine phosphokinase M-type", "tax_id": 9031, "disease": "", "pathway": " (gga:396248); (R-GGA-71288); (R-GGA-9696264)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10595529;19410564;20026305;2307674;2365692;3513124;3840441;7669815;8525081", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01001110.1, HAEL01000066.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1., [RefSeq]; Report the identity of a 45 kDa imidazoline binding protein to be brain creatine kinase and this enzyme possesses an I2 binding site; findings will undoubtedly contribute to greater understanding of and development of imidazoline therapeutic drugs., [RefSeq, PubMed]; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:20026305, PubMed:8525081). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q92061", "ec_number_list": "3.1.3.48;3.4.17.22;3.6.4.13;2.7.3.2", "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0006754 ATP biosynthetic process;GO:0140651 futile creatine cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P05122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31395-1", "uniprot_id": "STMN1_CHICK", "mass": 17082.0, "length": 148, "protein_name": "Stathmin", "gene_name": "STMN1", "organism": "Chicken", "refseq_name": "stathmin", "refseq_ac": "NP_001001858", "gene_names_uniprotkb": "STMN1; LAP18", "gene_names_refseq": "LAP18; STMN1", "protein_names_uniprotkb": "Stathmin", "protein_names_refseq": "leukemia-associated phosphoprotein p18; stathmin 1/oncoprotein 18; stathmin", "tax_id": 9031, "disease": "", "pathway": " (gga:396057)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7916696", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X65458.1, X67840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X67840.1. On Aug 30, 2004 this sequence version replaced XP_417751.1., [RefSeq]; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031175 neuron projection development;GO:0009615 response to virus;GO:0000281 mitotic cytokinesis;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31395-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32760-1", "uniprot_id": "PTN_CHICK", "mass": 18513.0, "length": 165, "protein_name": "Pleiotrophin", "gene_name": "PTN", "organism": "Chicken", "refseq_name": "pleiotrophin precursor", "refseq_ac": "NP_001263291", "gene_names_uniprotkb": "PTN", "gene_names_refseq": "HB-GAM; HBBM; HBGF-8; HBNF; OSF-1; PTN", "protein_names_uniprotkb": "Pleiotrophin; HB-GAM; HBBM; HBGF-8; HBNF; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; Heparin-binding neutrophic factor; OSF-1; Osteoblast-specific factor 1; PTN", "protein_names_refseq": "heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neutrophic factor; neurite growth-promoting factor 1; osteoblast-specific factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); pleiotrophin precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:418125); (R-GGA-201556); (R-GGA-9851151)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1550956;15592404;19526365;22496782;2388713", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.305020.1, SRR13267649.140839.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On or before Feb 2, 2013 this sequence version replaced XP_416358.1, XP_003640445.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; High pleiotrophin is associated with ovarian carcinomas., [RefSeq, PubMed]; Our results introduce Ptn as a novel marker gene in avian somite and tendon development., [RefSeq, PubMed]; Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PB28", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0035374 chondroitin sulfate binding;GO:0005178 integrin binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007507 heart development;GO:0007612 learning;GO:0008284 positive regulation of cell population proliferation;GO:0007420 brain development;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C1H4-1", "uniprot_id": "H2B5_CHICK", "mass": 13950.0, "length": 126, "protein_name": "Histone H2B 5", "gene_name": "H2B-V; H2BC35", "organism": "Chicken", "refseq_name": "histone H2B 5", "refseq_ac": "NP_001073189", "gene_names_uniprotkb": "H2B-V; H2BC35", "gene_names_refseq": "2B-V; H2B-V; H2BC35; HIST1H2B5; HIST1H2BN", "protein_names_uniprotkb": "Histone H2B 5; H2B V", "protein_names_refseq": "H2B V; histone H2B (AA 35 - 126); histone H2B 5; histone cluster 1, H2B-V (similar to human histone cluster 1, class H2B); histone cluster 1, H2bn", "tax_id": 9031, "disease": "", "pathway": " (gga:417957); (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-3214847); (R-GGA-427413); (R-GGA-5250924); (R-GGA-5689880); (R-GGA-5693565); (R-GGA-5693571); (R-GGA-5693607); (R-GGA-606279); (R-GGA-68616); (R-GGA-69473); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 27, "publication_count": 5, "publication_id_list": "12757711;12865423;2016071;2713375;8804862", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BU239197.1, BU452121.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Dec 12, 2006 this sequence version replaced XP_416197.2., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02279", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C1H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P04354-1", "uniprot_id": "CALB1_CHICK", "mass": 30167.0, "length": 262, "protein_name": "Calbindin", "gene_name": "CALB1", "organism": "Chicken", "refseq_name": "calbindin", "refseq_ac": "NP_990844", "gene_names_uniprotkb": "CALB1", "gene_names_refseq": "CALB1; CaBP-D28k", "protein_names_uniprotkb": "Calbindin; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type", "protein_names_refseq": "28-kDa vitamin D-dependent calcium-binding protein; CaBP-28; Calbindin D-28K; Calbindin D28k; Chicken intestinal 28-kilodalton calbindin-D; D-28K; calbindin 1, 28kDa; calbindin D28; calbindin; vitamin D-dependent calcium-binding protein, avian-type; vitamin D-induced calbindin-D28K", "tax_id": 9031, "disease": "", "pathway": " (gga:396519)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "23447106;23796121;25681476;2967915;3411606;3463988;3474624;3841205;9736748", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M14230.1, X03343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase., [UniProtKB, UniProtKB, UniProtKB]; Calbindin-D28k has significant roles in neuroplasticity of the retina during postnatal development, when it is stimulated with different light conditions., [RefSeq, PubMed]; Increase of transient receptor potential cation channel subfamily V member 6 (TRPV6) and calbindin-D28k expression during eggshell formation suggests that active Calcium(2+) transport exerts effects in delivering active calcium in egg shell gland, [RefSeq, PubMed]; The vector-based transient receptor potential vanilloid 6(TRPV6)-shRNA can efficiently suppress the mRNA and protein expression of TRPV6 in chicken osteoblasts, and TRPV6 regulates the expression of calbindin-D28K during Ca2+ transport., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005499 vitamin D binding;GO:0008270 zinc ion binding;GO:0099567 calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043195 terminal bouton;GO:0045202 synapse", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0019233 sensory perception of pain;GO:0007614 short-term memory;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04354-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZL72-1", "uniprot_id": "CH60_CHICK", "mass": 60973.0, "length": 573, "protein_name": "60 kDa heat shock protein, mitochondrial", "gene_name": "HSPD1", "organism": "Chicken", "refseq_name": "60 kDa heat shock protein, mitochondrial precursor", "refseq_ac": "NP_001012934", "gene_names_uniprotkb": "HSPD1; HSP60; RCJMB04_7g5", "gene_names_refseq": "HSPD1", "protein_names_uniprotkb": "60 kDa heat shock protein, mitochondrial; 5.6.1.7; 60 kDa chaperonin; CPN60; Chaperonin 60; HSP-60; Heat shock protein 60; Hsp60", "protein_names_refseq": "60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial precursor; 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; chaperonin 60; heat shock 60kDa protein 1 (chaperonin); heat shock protein 60; hsp60", "tax_id": 9031, "disease": "", "pathway": " (gga:424059); (R-GGA-1268020); (R-GGA-9837999)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15642098;16287166;24081778", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01009894.1, AJ719862.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06143078, SAMN08016559 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000236.1. On Mar 14, 2005 this sequence version replaced XP_421915.1., [RefSeq]; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mn had a dosage-dependent effect on HSP27, HSP40, HSP60, HSP70, and HSP90 mRNA expression in chicken spleen lymphocytes in vitro., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P84165", "ec_number_list": "1.4.1.3;3.4.21.53;1.2.4.1;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;2.5.1.39;1.3.8.1;1.3.8.5;2.3.1.9;2.1.3.3;3.6.4.10;5.3.3.21;4.98.1.1;4.2.1.2;2.3.3.10;2.7.1.23;1.16.3.1;5.3.3.8;5.6.2.3;1.2.4.2;3.5.3.1;6.4.1.3;2.3.1.-;7.1.2.2;1.2.1.3;1.1.1.37;2.7.11.-;6.1.1.5;5.6.1.7", "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0034186 apolipoprotein A-I binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0030135 coated vesicle;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005769 early endosome", "go_biological_process": "GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0032727 positive regulation of interferon-alpha production;GO:0043032 positive regulation of macrophage activation;GO:0045041 protein import into mitochondrial intermembrane space;GO:0048291 isotype switching to IgG isotypes", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZL72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "D0PRN2-1", "uniprot_id": "NRX1B_CHICK", "mass": 49956.0, "length": 466, "protein_name": "Neurexin-1-beta", "gene_name": "NRXN1", "organism": "Chicken", "refseq_name": "neurexin-1 isoform 2", "refseq_ac": "NP_001185905", "gene_names_uniprotkb": "NRXN1", "gene_names_refseq": "NRXN1", "protein_names_uniprotkb": "Neurexin-1-beta; Neurexin I-beta", "protein_names_refseq": "Neurexin-1-beta; neurexin I alpha; neurexin I-beta; neurexin-1 isoform 2; neurexin-1-alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:395398)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19926856", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU702427.1, SRR13267659.1551.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000061.1. Transcript Variant: This variant (2) differs in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 2 also known as beta) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Neurexins and neuroligins, which constitute large and complex families of fundamental players in synaptic activity, are produced and processed by endothelial and vascular smooth muscle cells throughout the vasculature., [RefSeq, PubMed]; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling (By similarity). Plays a role in angiogenesis., [UniProtKB, PubMed]; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0033130 acetylcholine receptor binding;GO:0005246 calcium channel regulator activity;GO:0050839 cell adhesion molecule binding;GO:0097109 neuroligin family protein binding", "go_cellular_component": "GO:0016020 membrane;GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0001944 vasculature development;GO:0035239 tube morphogenesis;GO:0099054 presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D0PRN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84247-1", "uniprot_id": "H33_CHICK", "mass": 15328.0, "length": 136, "protein_name": "Histone H3.3", "gene_name": "H3-3C; H3-IX; H3-X", "organism": "Chicken", "refseq_name": "histone H3.3", "refseq_ac": "NP_990627", "gene_names_uniprotkb": "H3-3C; H3-IX; H3-X", "gene_names_refseq": "H3-3B; H3-IX; H3-X; H3.3B; H3F3B", "protein_names_uniprotkb": "Histone H3.3; H3.3A/B; Histone H3 class II", "protein_names_refseq": "H3.3A/B; family 3B (H3.3B); histone H3 class II; histone H3.3", "tax_id": 9031, "disease": "", "pathway": " (gga:396233); (gga:427887); (R-GGA-212300); (R-GGA-2559580); (R-GGA-427413); (R-GGA-5250924); (R-GGA-68616); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-983231); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 21, "publication_count": 2, "publication_id_list": "2863747;3627987", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y00392.1, DR427769.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000316.1. On Aug 30, 2004 this sequence version replaced XP_429296.1., [RefSeq]; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P06351;P33155;Q9V3W4", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000786 nucleosome;GO:0005654 nucleoplasm", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P84247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F3L1-1", "uniprot_id": "KS6A5_CHICK", "mass": 89040.0, "length": 789, "protein_name": "Ribosomal protein S6 kinase alpha-5", "gene_name": "RPS6KA5", "organism": "Chicken", "refseq_name": "ribosomal protein S6 kinase alpha-5", "refseq_ac": "NP_001012605", "gene_names_uniprotkb": "RPS6KA5; RCJMB04_14g1", "gene_names_refseq": "RPS6KA5", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-5; 2.7.11.1; S6K-alpha-5", "protein_names_refseq": "S6K-alpha-5; ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; ribosomal protein S6 kinase, polypeptide 5", "tax_id": 9031, "disease": "", "pathway": " (gga:423408); (R-GGA-198753); (R-GGA-199920); (R-GGA-375165); (R-GGA-5621575)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851639.1, SRR13267655.50581.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000215.1. On Feb 28, 2005 this sequence version replaced XP_421318.1., [RefSeq]; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and that contributes to gene activation by histone phosphorylation. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.24;2.7.11.13;2.7.11.17;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0035175 histone H3S10 kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0043687 post-translational protein modification;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3L1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84023-1", "uniprot_id": "SMAD3_CHICK", "mass": 48252.0, "length": 426, "protein_name": "SMAD family member 3", "gene_name": "SMAD3", "organism": "Chicken", "refseq_name": "SMAD family member 3", "refseq_ac": "NP_989806", "gene_names_uniprotkb": "SMAD3; MADH3", "gene_names_refseq": "MAD3; MADH3; SMAD3", "protein_names_uniprotkb": "SMAD family member 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; Mothers against decapentaplegic homolog 3; SMAD 3", "protein_names_refseq": "MAD homolog 3; SMAD family member 3; SMAD, mothers against DPP homolog 3; TGF-beta response effector Smad3; mothers against DPP homolog 3; mothers against decapentaplegic homolog 3", "tax_id": 9031, "disease": "", "pathway": " (gga:395132); (R-GGA-1181150); (R-GGA-1502540); (R-GGA-2173788); (R-GGA-2173789); (R-GGA-2173795); (R-GGA-2173796); (R-GGA-5689880); (R-GGA-8941855); (R-GGA-9617828)", "pathway_count": 10, "publication_count": 6, "publication_id_list": "18753451;24105267;24570433;24757673;30930226;33878300", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY391265.1, SRR13267659.26354.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000246.1., [RefSeq]; Cell intercalation driven by SMAD3 underlies secondary neural tube formation., [RefSeq, PubMed]; IMF deposition in skeletal muscle of SLD chicken is regulated partially by pathways of adipocytokine and insulin and other downstream signaling pathways (TGF- beta /SMAD3 and Wnt/catenin- beta pathway)., [RefSeq, PubMed]; In chickens with reduced muscling, satellite cells are more responsive to a Smad3-dependent TGF-beta1 signaling pathway than normal satellite cells, and a Smad3-independent pathway is also likely involved in the regulation of satellite cells., [RefSeq, PubMed]; In conclusion, these studies suggested the decorin-mediated myostatin/Smad signaling pathway might be involved in the regulation of avian myoblast proliferation., [RefSeq, PubMed]; Results show that smad3 is phosphorylated after knocking-down CSRP3 suppressing chicken satellite cell differentiation., [RefSeq, PubMed]; Smad2 target proteins are activated solely by the Smad2-Smad2-Smad4 complex, whereas Smad3 targets are activated both by Smad2-Smad3-Smad4 and Smad3-Smad3-Smad4 trimers., [RefSeq, PubMed]; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0071141 SMAD protein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0060395 SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P84023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49337-1", "uniprot_id": "WNT4_CHICK", "mass": 38963.0, "length": 351, "protein_name": "Protein Wnt-4", "gene_name": "WNT4", "organism": "Chicken", "refseq_name": "protein Wnt-4 precursor", "refseq_ac": "NP_990114", "gene_names_uniprotkb": "WNT4; WNT-4", "gene_names_refseq": "WNT-4; WNT4", "protein_names_uniprotkb": "Protein Wnt-4", "protein_names_refseq": "Wnt-4 protein; protein Wnt-4 precursor; protein Wnt-4; wingless-type MMTV integration site family member 4", "tax_id": 9031, "disease": "", "pathway": " (gga:395561); (R-GGA-3238698)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12944424;17879321;23843947;7577679;7579581;7945308", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D31900.1, BU418913.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000329.1., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (By similarity)., [UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Plays an important role in embryonic development., [UniProtKB, UniProtKB, UniProtKB]; Studied Wnt4 & Wnt4a expression patterns in chick embryo nervous system, [RefSeq, PubMed]; The present results are identical to those of myostatin knockout, suggesting that Wnt4 is acting against myostatin as an antagonizing signal for myostatin., [RefSeq, PubMed]; WNT4 likely has crucial roles in development and function of oviduct as well as initiation of ovarian carcinogenesis in laying hens. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0003714 transcription corepressor activity;GO:0048018 receptor ligand activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0060993 kidney morphogenesis;GO:0014858 positive regulation of skeletal muscle cell proliferation;GO:0030182 neuron differentiation;GO:0060070 canonical Wnt signaling pathway;GO:0061036 positive regulation of cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49337-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0YZN0-1", "uniprot_id": "A0A8V0YZN0_CHICK", "mass": 77886.0, "length": 689, "protein_name": "Protein-glutamine gamma-glutamyltransferase 2", "gene_name": "TGM2", "organism": "Chicken", "refseq_name": "protein-glutamine gamma-glutamyltransferase 2", "refseq_ac": "NP_001378925", "gene_names_uniprotkb": "TGM2", "gene_names_refseq": "TGL2; TGM2", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 2; 2.3.2.13; 3.5.1.44; Isopeptidase TGM2; Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; Tissue transglutaminase; Transglutaminase-2", "protein_names_refseq": "TG(C); TGC; TGase C; TGase-2; erythrocyte transglutaminase; isopeptidase TGM2; protein-glutamine deamidase TGM2; protein-glutamine dopaminyltransferase TGM2; protein-glutamine gamma-glutamyltransferase 2; protein-glutamine histaminyltransferase TGM2; protein-glutamine noradrenalinyltransferase TGM2; protein-glutamine serotonyltransferase TGM2; tissue transglutaminase; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); transglutaminase C", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "24265319", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U47273.1, SRR13267648.29110.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000328.1. On Sep 23, 2021 this sequence version replaced NP_001378925.1., [RefSeq]; Data indicate that covalent collagen cross-links are formed by both lysyl oxidases and tissue transglutaminase-2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.13;3.5.1.44;3.4.-.-;2.3.1.-", "go_molecular_function": "GO:0005525 GTP binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0003810 protein-glutamine gamma-glutamyltransferase activity;GO:0050568 protein-glutamine glutaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0043065 positive regulation of apoptotic process;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8V0YZN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56517-1", "uniprot_id": "HDAC1_CHICK", "mass": 54939.0, "length": 480, "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "organism": "Chicken", "refseq_name": "histone deacetylase 1", "refseq_ac": "NP_989487", "gene_names_uniprotkb": "HDAC1; HDAC1A", "gene_names_refseq": "HDAC1A; HDAC1", "protein_names_uniprotkb": "Histone deacetylase 1; 3.5.1.-; 3.5.1.98; HD1; Protein deacetylase HDAC1; Protein deacylase HDAC1", "protein_names_refseq": "HD1; histone deacetylase 1; protein deacetylase HDAC1; protein deacylase HDAC1; protein decrotonylase HDAC1", "tax_id": 9031, "disease": "", "pathway": " (gga:373961); (R-GGA-1538133); (R-GGA-201722); (R-GGA-2173795); (R-GGA-350054); (R-GGA-3769402); (R-GGA-4551638); (R-GGA-6804758); (R-GGA-73762); (R-GGA-8936459); (R-GGA-8943724); (R-GGA-9018519); (R-GGA-9701898); (R-GGA-9764725); (R-GGA-9824594); (R-GGA-9825892); (R-GGA-983231); (R-GGA-9937850); (R-GGA-9940951)", "pathway_count": 19, "publication_count": 2, "publication_id_list": "19340485;20511365", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.21604.1, HAEK01019189.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000339.1. On Oct 4, 2007 this sequence version replaced XP_001233397.1., [RefSeq]; HDAC1 and HDAC2 are positive regulators of regenerative proliferation but they are not critical for avian hair cell differentiation., [RefSeq, PubMed]; Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcription levels at IgL and IgH were decreased in HDAC1(-/-) cells, while other genes actively transcribed in B cells were slightly up-regulated compared to the levels in wild-type cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.98;1.14.99.66;2.3.1.48;3.5.1.-;2.3.2.-", "go_molecular_function": "GO:0035851 Krueppel-associated box domain binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56517-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Z7U1-1", "uniprot_id": "A0A8V0Z7U1_CHICK", "mass": 21617.0, "length": 207, "protein_name": "protein deglycase", "gene_name": "PARK7", "organism": "Chicken", "refseq_name": "protein/nucleic acid deglycase DJ-1 isoform X1", "refseq_ac": "XP_040507028", "gene_names_uniprotkb": "PARK7", "gene_names_refseq": "DJ-1; PARK7", "protein_names_uniprotkb": "protein deglycase; 3.5.1.124; Maillard deglycase; Parkinsonism-associated deglycase", "protein_names_refseq": "protein/nucleic acid deglycase DJ-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3899300); (R-GGA-9646399)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 2% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052552.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;3.5.1.124;2.3.2.-;3.1.2.-;3.5.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0008233 peptidase activity;GO:0036524 protein deglycase activity;GO:1990422 glyoxalase (glycolic acid-forming) activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0006979 response to oxidative stress;GO:0007338 single fertilization;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Z7U1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1BY77-1", "uniprot_id": "UBP13_CHICK", "mass": 96649.0, "length": 862, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 13", "gene_name": "USP13", "organism": "Chicken", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 13", "refseq_ac": "NP_001292032", "gene_names_uniprotkb": "USP13", "gene_names_refseq": "USP13", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 13; 3.4.19.12; Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13", "protein_names_refseq": "deubiquitinating enzyme 13; ubiquitin carboxyl-terminal hydrolase 13; ubiquitin specific peptidase 13 (isopeptidase T-3); ubiquitin thioesterase 13; ubiquitin-specific-processing protease 13", "tax_id": 9031, "disease": "", "pathway": " (gga:429286); (R-GGA-5689880); (R-GGA-8948751)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. On Dec 3, 2021 this sequence version replaced NP_001292032.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.19.12;3.1.3.67;3.1.3.16;3.1.3.48;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:1904288 BAT3 complex binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0008283 cell population proliferation;GO:0010506 regulation of autophagy;GO:0070536 protein K63-linked deubiquitination;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BY77-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1BTW5-1", "uniprot_id": "E1BTW5_CHICK", "mass": 133519.0, "length": 1216, "protein_name": "Delta-like protein", "gene_name": "JAG1", "organism": "Chicken", "refseq_name": "protein jagged-1 isoform X1", "refseq_ac": "XP_415035", "gene_names_uniprotkb": "JAG1", "gene_names_refseq": "JAG1", "protein_names_uniprotkb": "Delta-like protein", "protein_names_refseq": "protein jagged-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:396043); (R-GGA-9013149); (R-GGA-9013423); (R-GGA-9013507)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_415035.3. COMPLETENESS: full length., [RefSeq]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0060090 molecular adaptor activity;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0007219 Notch signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BTW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27177-1", "uniprot_id": "PRIO_CHICK", "mass": 29909.0, "length": 273, "protein_name": "Major prion protein homolog", "gene_name": "PRNP", "organism": "Chicken", "refseq_name": "major prion protein homolog preproprotein", "refseq_ac": "NP_990796", "gene_names_uniprotkb": "PRNP; PRN-P", "gene_names_refseq": "PRNP; Prn-p; prp", "protein_names_uniprotkb": "Major prion protein homolog; 65-21 protein; ARIA; Acetylcholine receptor-inducing activity; PR-LP", "protein_names_refseq": "65-21 protein; ARIA; PR-LP; acetylcholine receptor-inducing activity; major prion protein homolog preproprotein; major prion protein homolog; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion-like-protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396452); (R-GGA-163125); (R-GGA-9609523)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1409608;15647366;1715573;17560545;19751818;2132829;31795947", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M61145.1, SRR13267659.276457.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JAENSK010000331.1. On Nov 22, 2012 this sequence version replaced NP_990796.1. This gene encodes a membrane glycosylphosphatidylinositol-anchored glycoprotein found in the central nervous system. In human and other vertebrates, the homologous protein is associated with neurodegenerative diseases that result from improper protein metabolism. [provided by RefSeq, Nov 2012]. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The absence of SNPs in the chicken PRNP ORF is a notable feature of animals with perfect resistant to prion disease. Publication Status: Online-Only, [RefSeq, PubMed]; Thermostability of Human PrP(C) is comparable with that of chicken PrP(C), [RefSeq, PubMed]; These findings suggest that PrP in the chicken CNS is localized in the dendrites and axons of neurons and that it is associated with certain sensory systems., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043083 synaptic cleft;GO:0005604 basement membrane;GO:0098552 side of membrane;GO:0009986 cell surface", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0071280 cellular response to copper ion;GO:0035556 intracellular signal transduction;GO:1904646 cellular response to amyloid-beta;GO:0050850 positive regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P27177-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60878-1", "uniprot_id": "SNP25_CHICK", "mass": 23315.0, "length": 206, "protein_name": "Synaptosomal-associated protein 25", "gene_name": "SNAP25", "organism": "Chicken", "refseq_name": "synaptosomal-associated protein 25", "refseq_ac": "NP_001385139", "gene_names_uniprotkb": "SNAP25; SNAP", "gene_names_refseq": "SNAP-25; SNAP25; SNAP", "protein_names_uniprotkb": "Synaptosomal-associated protein 25; SNAP-25; SUP; Super protein; Synaptosomal-associated 25 kDa protein", "protein_names_refseq": "SUP; super protein; synaptosomal-associated 25 kDa protein; synaptosomal-associated protein 25; synaptosomal-associated protein, 25kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:396444); (R-GGA-181429); (R-GGA-181430); (R-GGA-212676); (R-GGA-264642); (R-GGA-449836); (R-GGA-6798695); (R-GGA-888590)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "1992470;8377193", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01028212.1, HAEK01068445.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HAEK01028212.1. On Dec 10, 2021 this sequence version replaced XP_015138942.1., [RefSeq]; Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion., [UniProtKB, UniProtKB, UniProtKB]; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13795;P36974;P70557;P70558;Q8IXK3;Q96FM2;Q9BR45", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0006887 exocytosis;GO:0010975 regulation of neuron projection development;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0016082 synaptic vesicle priming;GO:0099525 presynaptic dense core vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P60878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62207-1", "uniprot_id": "PP1B_CHICK", "mass": 37187.0, "length": 327, "protein_name": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit", "gene_name": "PPP1CB", "organism": "Chicken", "refseq_name": "serine/threonine-protein phosphatase PP1-beta catalytic subunit", "refseq_ac": "NP_990453", "gene_names_uniprotkb": "PPP1CB", "gene_names_refseq": "PPP1CB", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-beta catalytic subunit; 3.1.3.16; 3.1.3.53; PP-1B", "protein_names_refseq": "PP-1B; protein phosphatase 1, catalytic subunit, beta isozyme; protein phosphatase 1, catalytic subunit, delta (gizzard); serine/threonine-protein phosphatase PP1-beta catalytic subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:396019); (R-GGA-2565942); (R-GGA-5627123); (R-GGA-5673000); (R-GGA-9770562)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "1336455;15164081;7982954", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888521.54145.1, HAEK01057781.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992453 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1., [RefSeq]; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P37140", "ec_number_list": "3.1.3.16;3.1.3.48;3.6.4.13;2.7.11.1;2.7.7.19;2.3.2.27;3.1.3.67;3.1.3.27;3.1.3.74;2.7.7.6;2.7.11.21;3.1.3.53;2.7.1.78", "go_molecular_function": "GO:0050115 myosin-light-chain-phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0017018 myosin phosphatase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0072357 PTW/PP1 phosphatase complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0051301 cell division;GO:0005977 glycogen metabolic process;GO:0042752 regulation of circadian rhythm;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Z5J2-1", "uniprot_id": "A0A8V0Z5J2_CHICK", "mass": 165265.0, "length": 1483, "protein_name": "Phospholipase B1, membrane-associated", "gene_name": "PLB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PLB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipase B1, membrane-associated; 3.1.1.3; 3.1.1.4; 3.1.1.5; Lysophospholipase; Phospholipase A2; Phospholipase B/lipase; Triacylglycerol lipase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1482788); (R-GGA-975634)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.22;3.1.1.32;3.1.1.3;3.1.1.23;3.1.1.79;3.1.1.5;3.1.1.4;1.11.1.27;3.5.1.1;3.1.1.47;3.1.1.116;3.1.1.-;3.1.1.6;3.1.1.34;3.1.-.-;2.3.1.23", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Z5J2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41263-1", "uniprot_id": "RET4_CHICK", "mass": 22515.0, "length": 196, "protein_name": "Retinol-binding protein 4", "gene_name": "RBP4", "organism": "Chicken", "refseq_name": "retinol-binding protein 4 precursor", "refseq_ac": "NP_990569", "gene_names_uniprotkb": "RBP4", "gene_names_refseq": "RBP4A; RBP4; RBP", "protein_names_uniprotkb": "Retinol-binding protein 4; PRBP; Plasma retinol-binding protein; RBP", "protein_names_refseq": "PRBP; plasma retinol-binding protein; retinol binding protein 4 A, plasma; retinol binding protein 4, plasma; retinol-binding protein 4 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396166); (R-GGA-2453902); (R-GGA-975634)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11738088;22499871;7748490;9270874", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU239709.1, X77960.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992527, SAMEA103992543 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000232.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Excessive vitamin E could increase the concentration of vitamin A in liver by inhibiting retinol binding protein synthesis in hepatocytes., [RefSeq, PubMed]; In the absence of retinol, the constitutive secretion of chicken plasma RBP is higher than the human plasma retinol-binding protein., [RefSeq, PubMed]; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0034632 retinol transmembrane transporter activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0070062 extracellular exosome;GO:0030136 clathrin-coated vesicle;GO:0060417 yolk;GO:0060418 yolk plasma", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0030277 maintenance of gastrointestinal epithelium;GO:0042572 retinol metabolic process;GO:0006094 gluconeogenesis;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P41263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14315-1", "uniprot_id": "CAPZB_CHICK", "mass": 31364.0, "length": 277, "protein_name": "F-actin-capping protein subunit beta isoforms 1 and 2", "gene_name": "CAPZB", "organism": "Chicken", "refseq_name": "capping protein (actin filament) muscle Z-line, beta isoform 2", "refseq_ac": "NP_001167000", "gene_names_uniprotkb": "CAPZB", "gene_names_refseq": "CAPZB", "protein_names_uniprotkb": "F-actin-capping protein subunit beta isoforms 1 and 2; Beta-actinin subunit II; CapZ 36/32; CapZ B1 and B2", "protein_names_refseq": "F-actin-capping protein subunit beta; actin-capping protein Z (cap-Z) beta subunit; beta-actinin subunit II; capZ 36/32; capZ B1 and B2; capping protein (actin filament) muscle Z-line, beta isoform 2; capping protein (actin filament) muscle Z-line, beta", "tax_id": 9031, "disease": "", "pathway": " (gga:396418)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2341404;2745461;7929588", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN210823.1, CN210822.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171, SAMN06140853 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000329.1. Transcript Variant: This variant lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005903 brush border;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0051490 negative regulation of filopodium assembly;GO:0010591 regulation of lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P14315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37042-1", "uniprot_id": "GON1_CHICK", "mass": 10206.0, "length": 92, "protein_name": "Progonadoliberin-1", "gene_name": "GNRH1", "organism": "Chicken", "refseq_name": "progonadoliberin-1 precursor", "refseq_ac": "NP_001074346", "gene_names_uniprotkb": "GNRH1", "gene_names_refseq": "CGNRH-I; GNRH1; GnRH-1; GnRH-I; GnRHI; LHRH-I", "protein_names_uniprotkb": "Progonadoliberin-1; GnRH-I; GnRH-associated peptide I; Gonadoliberin I; Gonadotropin-releasing hormone I; LH-RH I; Luliberin I; Luteinizing hormone-releasing hormone I; Progonadoliberin I", "protein_names_refseq": "Gonadotrophin releasing hormone I; chicken gonadotrophin releasing hormone-I; gonadotrophin-releasing hormone I; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); luteinizing hormone releasing hormone I; progonadoliberin I; progonadoliberin-1 precursor; progonadoliberin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:770134); (R-GGA-375281); (R-GGA-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21872303;22200593;25867433;30686025;3325608;7050118;7050119;7902095", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992528, SAMEA103992531 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X69491.1. On Jan 30, 2007 this sequence version replaced XP_001233455.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that the gonadotropin-releasing hormone (GnRH) protein was discovered to be expressed successfully in Escherichia coli BL21 cells. Publication Status: Online-Only, [RefSeq, PubMed]; FGF signaling is required and sufficient to induce GnRH-1 neurons in the olfactory placode, where they are specified shortly after olfactory sensory neurons., [RefSeq, PubMed]; GNRH1 stimulates LH release from the pituitary in vivo with differences in response between males and females, [RefSeq, PubMed]; Results indicate that GnRH-I expression is correlated with the reproductive state in the native Thai chicken and may be, in part, regulated by it; study also confirms a pivotal role of GnRH-I in controlling avian reproduction of this non-seasonal breeding, equatorial species, [RefSeq, PubMed]; Stimulates the secretion of gonadotropins., [UniProtKB]; The haplogroups of GnRHI had a significant effect on body weight and egg production up to 64 weeks of age, yolk content, Haugh units and egg shell parameters. The h1h2 haplogroup of the GnRHI gene showed the highest egg production, with 211.0 +/- 24.3 eggs up to 64 weeks of age, while the highest yolk content and Haugh unit was found in h3h10 haplogrouped birds., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20407", "ec_number_list": "", "go_molecular_function": "GO:0005183 gonadotropin hormone-releasing hormone activity;GO:0031530 gonadotropin-releasing hormone receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon;GO:0043204 perikaryon", "go_biological_process": "GO:0043279 response to alkaloid;GO:0032275 luteinizing hormone secretion;GO:0023051 regulation of signaling;GO:0046885 regulation of hormone biosynthetic process;GO:0033686 positive regulation of luteinizing hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P37042-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1BRC0-1", "uniprot_id": "E1BRC0_CHICK", "mass": 110453.0, "length": 974, "protein_name": "Vacuolar protein sorting-associated protein 54", "gene_name": "VPS54", "organism": "Chicken", "refseq_name": "vacuolar protein sorting-associated protein 54 isoform X1", "refseq_ac": "XP_419349", "gene_names_uniprotkb": "VPS54", "gene_names_refseq": "VPS54", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 54", "protein_names_refseq": "vacuolar protein sorting-associated protein 54 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6811440)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_419349.2. COMPLETENESS: full length., [RefSeq]; Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000938 GARP complex;GO:0005829 cytosol;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0048708 astrocyte differentiation;GO:0010992 ubiquitin recycling;GO:0071393 cellular response to progesterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BRC0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42252-1", "uniprot_id": "LDB1_CHICK", "mass": 46606.0, "length": 411, "protein_name": "LIM domain-binding protein 1", "gene_name": "LDB1", "organism": "Chicken", "refseq_name": "LIM domain-binding protein 1", "refseq_ac": "NP_990401", "gene_names_uniprotkb": "LDB1; CLIM2; NSIP", "gene_names_refseq": "CLIM2; LDB1; NSIP", "protein_names_uniprotkb": "LIM domain-binding protein 1; CLIM-2; Carboxyl-terminal LIM domain-binding protein 2; LDB-1; LIM domain-binding factor CLIM2; Neural Src-interacting protein; Nuclear LIM interactor; cLdb1", "protein_names_refseq": "CLIM-2; LDB-1; LIM domain-binding factor CLIM2; LIM domain-binding protein 1; cLdb1; carboxyl-terminal LIM domain-binding protein 2; neural Src-interacting protein; neural src interacting protein; nuclear LIM interactor", "tax_id": 9031, "disease": "", "pathway": " (gga:395952); (R-GGA-8939236)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10431247;16815859", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF026037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000232.1. On Aug 30, 2004 this sequence version replaced XP_429276.1., [RefSeq]; Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1EQX0;Q78CQ9;Q9PWE7", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0030274 LIM domain binding;GO:0003712 transcription coregulator activity;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0032991 protein-containing complex;GO:0031252 cell leading edge;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O42252-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NNP2-1", "uniprot_id": "F1NNP2_CHICK", "mass": 47623.0, "length": 412, "protein_name": "Transforming growth factor beta", "gene_name": "TGFB2", "organism": "Chicken", "refseq_name": "transforming growth factor beta-2 proprotein precursor", "refseq_ac": "NP_001026216", "gene_names_uniprotkb": "TGFB2", "gene_names_refseq": "TGF-beta-2; TGFB2", "protein_names_uniprotkb": "Transforming growth factor beta", "protein_names_refseq": "TGF beta2; transforming growth factor beta-2 proprotein precursor; transforming growth factor beta-2 proprotein; transforming growth factor-beta2", "tax_id": 9031, "disease": "", "pathway": " (gga:421352); (R-GGA-114608); (R-GGA-2129379); (R-GGA-2173789); (R-GGA-9839389)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "24299181;24769017;33214222;34828300", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.24126.1, SRR13267658.14285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02738229 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000062.1. On or before Jun 3, 2014 this sequence version replaced XP_003641018.1, NP_001026216.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates and exon combination used for the transcript record were based on alignment to mRNA EF541127.1 from domestic goose (Anser anser, taxonomy id 8843). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; MiR-301a-5p Regulates TGFB2 during Chicken Spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal., [UniProtKB, UniProtKB, UniProtKB]; Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively., [UniProtKB, UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2., [UniProtKB, UniProtKB, UniProtKB]; Results show that Cadherin-11 may function as an effector of Decorin and that both Decorin and TGFbeta2 present an overlapping pattern of expression in joint and tendon blastemas of the embryonic digits., [RefSeq, PubMed]; SNPs of GHSR C3286 > T and TGFB2 T(-640) > C were genotyped in sire and dam lines of a broiler chicken to evaluate the association with the growth and body composition traits., [RefSeq, PubMed]; The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity;GO:0034714 type III transforming growth factor beta receptor binding;GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region;GO:0005768 endosome;GO:0030424 axon;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051781 positive regulation of cell division;GO:0009888 tissue development;GO:0048513 animal organ development;GO:0009653 anatomical structure morphogenesis;GO:1904888 cranial skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1NNP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19336-1", "uniprot_id": "CCN1_CHICK", "mass": 40652.0, "length": 375, "protein_name": "CCN family member 1", "gene_name": "CCN1; CYR61", "organism": "Chicken", "refseq_name": "CCN family member 1 precursor", "refseq_ac": "NP_001026734", "gene_names_uniprotkb": "CCN1; CYR61; CYR61", "gene_names_refseq": "CCN1; CYR61", "protein_names_uniprotkb": "CCN family member 1; Cellular communication network factor 1; Protein CEF-10; Protein CYR61", "protein_names_refseq": "CCN family member 1 precursor; CCN family member 1; Protein CEF-10; cellular communication network factor 1; protein CYR61", "tax_id": 9031, "disease": "", "pathway": " (gga:429089); (R-GGA-381426); (R-GGA-8957275)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21931747;2537491;26662056;31145521", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: J04496.1, SRR13267662.35973.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992393 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000239.1. On Aug 8, 2005 this sequence version replaced XP_426645.1., [RefSeq]; Ccn1 appeared as a precocious marker of the digit blastemas. As development progressed, transcripts accumulated in the developing joints and in the tendon blastemas, whereas expression in the digit rays was restricted to the distal phalanx in course of differentiation. Interdigital implantation of beads bearing CCN1 induced the upregulation of Tenascin C and the downregulation of CG-8, [RefSeq, PubMed]; Overexpression of Btg1 induced intense upregulation of Ccn1. In complementary knockdown experiments, this marker was regulated in an opposite fashion., [RefSeq, PubMed]; Probable secreted regulatory protein., [UniProtKB]; Upregulation of Cyr61 significantly decreased IM-induced cellular apoptosis of K562 cells through nuclear factor kappa B/B-cell lymphoma 2 pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0030335 positive regulation of cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19336-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63283-1", "uniprot_id": "UBC9_CHICK", "mass": 18007.0, "length": 158, "protein_name": "SUMO-conjugating enzyme UBC9", "gene_name": "UBE2I", "organism": "Chicken", "refseq_name": "SUMO-conjugating enzyme UBC9", "refseq_ac": "NP_001383751", "gene_names_uniprotkb": "UBE2I; UBC9; UBCE9", "gene_names_refseq": "UBC9; UBCE9; UBE2I", "protein_names_uniprotkb": "SUMO-conjugating enzyme UBC9; 2.3.2.-; RING-type E3 SUMO transferase UBC9; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I", "protein_names_refseq": "RING-type E3 SUMO transferase UBC9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-protein ligase I", "tax_id": 9031, "disease": "", "pathway": " (gga:374123); (R-GGA-196791); (R-GGA-3065678); (R-GGA-3108214); (R-GGA-3232118); (R-GGA-3232142); (R-GGA-3899300); (R-GGA-4085377); (R-GGA-4090294); (R-GGA-4551638); (R-GGA-4570464); (R-GGA-4615885); (R-GGA-4655427); (R-GGA-4755510); (R-GGA-5693565); (R-GGA-5693607); (R-GGA-5696395); (R-GGA-8866904); (R-GGA-9615933); (R-GGA-9793242); (R-GGA-9856649); (R-GGA-9937850)", "pathway_count": 22, "publication_count": 2, "publication_id_list": "12413887;23382206", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CV861206.1, CO771426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Oct 25, 2021 this sequence version replaced XP_015149596.1., [RefSeq]; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P50550;Q15698;Q547R1;Q86VB3", "ec_number_list": "2.3.2.27;3.6.4.13;2.3.1.48;5.6.2.2;2.3.2.26;2.1.1.37;2.7.11.1;2.3.2.-;3.5.1.98;5.6.2.4;2.1.1.357;3.5.1.124;2.4.2.-;2.4.2.30;5.6.2.1;1.14.11.66;1.14.11.69;3.5.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0008134 transcription factor binding;GO:0043398 HLH domain binding;GO:0001221 transcription coregulator binding;GO:0071535 RING-like zinc finger domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0048471 perinuclear region of cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation;GO:0016925 protein sumoylation;GO:0030335 positive regulation of cell migration;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63283-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00356-1", "uniprot_id": "G3P_CHICK", "mass": 35704.0, "length": 333, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase", "gene_name": "GAPDH", "organism": "Chicken", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase", "refseq_ac": "NP_989636", "gene_names_uniprotkb": "GAPDH; GAPD", "gene_names_refseq": "GAPDH; GAPD; KNC-NDS6", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase; 1.2.1.12; 2.6.99.-; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH", "protein_names_refseq": "glyceraldehyde-3-phosphate dehydrogenase; peptidyl-cysteine S-nitrosylase GAPDH", "tax_id": 9031, "disease": "", "pathway": " (gga:374193); (R-GGA-352875); (R-GGA-352882); (R-GGA-70171); (R-GGA-70263)", "pathway_count": 5, "publication_count": 23, "publication_id_list": "1593633;16287166;2110163;23099774;2985560;3094011;3539098;3856841;3885220;4463937;499525;6179937;6303388;6322764;6345546;6574503;6687938;7629021;7768978;7916593;8182283;9434147;9736461", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF047874.1, HAEK01110898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000015.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis. Also shows nitrosylase activity, thereby playing a role in nuclear functions (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results show that despite being commonly used housekeeping genes neither GAPDH mRNA nor beta-actin mRNA is expressed in all cell types or tissues at high levels. Strikingly, expression levels are very low in some organs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90848;Q90849;Q98926", "ec_number_list": "1.2.1.12;2.6.99.-", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0097718 disordered domain specific binding;GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006094 gluconeogenesis;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P00356-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51027-1", "uniprot_id": "NRAM1_CHICK", "mass": 60967.0, "length": 555, "protein_name": "Natural resistance-associated macrophage protein 1", "gene_name": "SLC11A1", "organism": "Chicken", "refseq_name": "natural resistance-associated macrophage protein 1", "refseq_ac": "NP_990295", "gene_names_uniprotkb": "SLC11A1; NRAMP1", "gene_names_refseq": "BCG; NRAMP1; SLC11A1", "protein_names_uniprotkb": "Natural resistance-associated macrophage protein 1; NRAMP 1; Solute carrier family 11 member 1", "protein_names_refseq": "NRAMP 1; natural resistance-associated macrophage protein 1; natural resistant-associated macrophage protein 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395811); (R-GGA-1222556); (R-GGA-425410); (R-GGA-6798695); (R-GGA-6803544)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "29884179;8634139", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.169236.1, U40598.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000236.1., [RefSeq]; Expression of NRAMP1 and NRAMP2 genes was differentially regulated after infection in tissues such as liver, spleen and caecum known to be the target of Salmonella Typhimurium replication in the chicken. Publication Status: Online-Only, [RefSeq, PubMed]; Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0015086 cadmium ion transmembrane transporter activity;GO:0046915 transition metal ion transmembrane transporter activity;GO:0051139 metal cation:proton antiporter activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0006829 zinc ion transport;GO:0034755 iron ion transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0030001 metal ion transport;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51027-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P68259-1", "uniprot_id": "GLUC_CHICK", "mass": 23876.0, "length": 206, "protein_name": "Pro-glucagon", "gene_name": "GCG", "organism": "Chicken", "refseq_name": "pro-glucagon isoform 1 preproprotein", "refseq_ac": "NP_001177094", "gene_names_uniprotkb": "GCG", "gene_names_refseq": "GCG; GLP1; GLP2; GRPP", "protein_names_uniprotkb": "Pro-glucagon", "protein_names_refseq": "glicentin-related polypeptide; glucagon preproprotein; glucagon-like peptide 1; glucagon-like peptide 2; preproglucagon A; preproglucagon B; pro-glucagon isoform 1 preproprotein; pro-glucagon", "tax_id": 9031, "disease": "", "pathway": " (gga:396196); (R-GGA-163359); (R-GGA-381771); (R-GGA-416476); (R-GGA-418555); (R-GGA-420092); (R-GGA-422085)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "1194290;2338135;23651280;26260898;27150835;28108848;2828209;7776976", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ185931.1, HAEL01001381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000236.1. Transcript Variant: This variant (3) encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene.The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show there was an interaction of line and nutrition on preproglucagon (PPG) and glucose transporter GLUT2 mRNA expression., [RefSeq, PubMed]; It plays a role in the regulation of food intake in chickens. (review) Review article, [RefSeq, PubMed]; Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis., [UniProtKB, UniProtKB]; Potent stimulator of glucose-dependent insulin release. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation., [UniProtKB, UniProtKB]; Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability., [UniProtKB, UniProtKB]; These data show that the quantity of food intake is one of signals that have an influence on the secretion of GLP-1 from L cells in the chicken small intestine., [RefSeq, PubMed]; These findings reveal that the cells producing both GLP-1 and NT are mainly localized in the crypts of the chicken ileum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01277;Q91410", "ec_number_list": "", "go_molecular_function": "GO:0031769 glucagon receptor binding;GO:0042802 identical protein binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0071377 cellular response to glucagon stimulus;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P68259-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27607-1", "uniprot_id": "PGH2_CHICK", "mass": 69112.0, "length": 603, "protein_name": "Prostaglandin G/H synthase 2", "gene_name": "PTGS2", "organism": "Chicken", "refseq_name": "prostaglandin G/H synthase 2 isoform 2", "refseq_ac": "NP_001161190", "gene_names_uniprotkb": "PTGS2; CEF-147", "gene_names_refseq": "CEF-147; CEF147; PGHS2; PHSII; PTGS2", "protein_names_uniprotkb": "Prostaglandin G/H synthase 2; 1.14.99.1; COX-2; Cyclooxygenase-2; Mitogen-inducible PGHS; PGH synthase 2; PGHS-2; PHS II; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2", "protein_names_refseq": "COX-2; PGH synthase 2; PGHS-2; PHS II; cyclooxygenase-2; mitogen-inducible PGHS; prostaglandin G/H synthase 2 isoform 2; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)", "tax_id": 9031, "disease": "", "pathway": " (gga:396451); (R-GGA-2142770); (R-GGA-2162123); (R-GGA-9018677); (R-GGA-9018679); (R-GGA-9025094); (R-GGA-9027604)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "1849272;18498063;33454433", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: ERR2286007.103709.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000238.1. On or before Nov 18, 2009 this sequence version replaced XP_422297.1, XP_001231379.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1., [RefSeq]; COX-2 mRNA expression did not change as a function of age or in ovarian cancer, [RefSeq, PubMed]; Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection. In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; New insights into the obligatory nature of cyclooxygenase-2 and PGE2 during early chick embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.99.1", "go_molecular_function": "GO:0004666 prostaglandin-endoperoxide synthase activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0043005 neuron projection;GO:0005788 endoplasmic reticulum lumen;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008217 regulation of blood pressure;GO:0019371 cyclooxygenase pathway;GO:0001516 prostaglandin biosynthetic process;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P27607-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18625-1", "uniprot_id": "FOSL2_CHICK", "mass": 35242.0, "length": 323, "protein_name": "Fos-related antigen 2", "gene_name": "FOSL2", "organism": "Chicken", "refseq_name": "fos-related antigen 2", "refseq_ac": "NP_001039301", "gene_names_uniprotkb": "FOSL2; FRA-2", "gene_names_refseq": "FOSL2; fra-2", "protein_names_uniprotkb": "Fos-related antigen 2; FRA-2", "protein_names_refseq": "FOS like antigen 2; fos-related antigen 2", "tax_id": 9031, "disease": "", "pathway": " (gga:421416)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2110368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.225930.1, SRR12888499.83120.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02738227 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1. On Sep 5, 2006 this sequence version replaced XP_419469.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0032905 transforming growth factor beta1 production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18625-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZJ28-1", "uniprot_id": "A0A8V0ZJ28_CHICK", "mass": 47196.0, "length": 403, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "gene_name": "PTEN", "organism": "Chicken", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1", "refseq_ac": "XP_040530729", "gene_names_uniprotkb": "PTEN", "gene_names_refseq": "PTEN", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; 3.1.3.16; 3.1.3.48; 3.1.3.67; Phosphatase and tensin homolog", "protein_names_refseq": "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1660499); (R-GGA-1855204); (R-GGA-199418); (R-GGA-202424); (R-GGA-5689880); (R-GGA-5689896); (R-GGA-8948747); (R-GGA-8948751)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052578.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;3.4.19.12;2.3.2.27;2.4.2.-;2.3.2.26;3.1.3.67;3.1.3.86;3.1.3.95;2.7.10.2;3.1.3.27;3.1.3.62;3.1.3.80;3.1.3.21;3.1.3.74;3.1.3.53;3.1.3.18;3.1.3.2", "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity;GO:0042802 identical protein binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZJ28-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZQQ4-1", "uniprot_id": "A0A8V0ZQQ4_CHICK", "mass": 102282.0, "length": 907, "protein_name": "ATP-binding cassette sub-family B member 6", "gene_name": "ABCB6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ABCB6", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-binding cassette sub-family B member 6; 7.6.2.5; ABC-type heme transporter ABCB6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:425721); (R-GGA-1369007)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.5", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015439 ABC-type heme transporter activity;GO:0015562 efflux transmembrane transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:1903232 melanosome assembly;GO:0055085 transmembrane transport;GO:0007420 brain development;GO:0006779 porphyrin-containing compound biosynthetic process;GO:0015886 heme transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZQQ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZSC5-1", "uniprot_id": "A0A8V0ZSC5_CHICK", "mass": 47510.0, "length": 415, "protein_name": "Phospholipase A2 group XV", "gene_name": "PLA2G15", "organism": "Chicken", "refseq_name": "phospholipase A2 group XV", "refseq_ac": "XP_001231519", "gene_names_uniprotkb": "PLA2G15", "gene_names_refseq": "PLA2G15", "protein_names_uniprotkb": "Phospholipase A2 group XV", "protein_names_refseq": "phospholipase A2 group XV", "tax_id": 9031, "disease": "", "pathway": " (gga:768530); (R-GGA-1483115)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008374 O-acyltransferase activity;GO:0008270 zinc ion binding;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006672 ceramide metabolic process;GO:0046470 phosphatidylcholine metabolic process;GO:0046471 phosphatidylglycerol metabolic process;GO:0006658 phosphatidylserine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZSC5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NLP2-1", "uniprot_id": "F1NLP2_CHICK", "mass": 46484.0, "length": 408, "protein_name": "Protein-serine/threonine kinase", "gene_name": "PDK1", "organism": "Chicken", "refseq_name": "pyruvate dehydrogenase kinase, isozyme 1", "refseq_ac": "NP_001026523", "gene_names_uniprotkb": "PDK1", "gene_names_refseq": "PDK1", "protein_names_uniprotkb": "Protein-serine/threonine kinase; 2.7.11.-", "protein_names_refseq": "pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1", "tax_id": 9031, "disease": "", "pathway": " (gga:425972); (R-GGA-204174); (R-GGA-5362517); (R-GGA-9837999)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "23893244", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.209455.1, AJ719650.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000236.1. On Dec 28, 2010 this sequence version replaced NP_001026523.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Data propose that PDK1 functions as a cellular sensor that balances basal PIP3 generation at levels sufficient for survival but below a threshold being harmful to the cell., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.4.1.3;3.4.21.53;1.2.4.1;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;2.7.11.-;1.3.8.1;1.3.8.5;2.3.1.9;3.6.4.10;1.8.1.4;5.3.3.21;4.98.1.1;4.2.1.2;2.3.3.10;2.7.1.23;5.3.3.8;5.6.2.3;1.2.4.2;3.5.3.1;2.3.1.12;6.4.1.3;2.3.1.-;7.1.2.2;1.2.1.3;1.1.1.37;6.1.1.5;5.6.1.7", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0010906 regulation of glucose metabolic process;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1NLP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4R0X9-1", "uniprot_id": "Q4R0X9_CHICK", "mass": 24862.0, "length": 214, "protein_name": "Fibroblast growth factor", "gene_name": "FGF8", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FGF8", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396313); (R-GGA-109704); (R-GGA-1257604); (R-GGA-190322); (R-GGA-190371); (R-GGA-190372); (R-GGA-190373); (R-GGA-190375); (R-GGA-5654219); (R-GGA-5654221); (R-GGA-5654227); (R-GGA-5654228); (R-GGA-5654687); (R-GGA-5654688); (R-GGA-5654689); (R-GGA-5654693); (R-GGA-5654695); (R-GGA-5654699); (R-GGA-5654700); (R-GGA-5654704); (R-GGA-5654706); (R-GGA-5654710); (R-GGA-5654712); (R-GGA-5654719); (R-GGA-5654720); (R-GGA-5654726); (R-GGA-5654727); (R-GGA-5654732); (R-GGA-5654733); (R-GGA-5658623); (R-GGA-5673001); (R-GGA-6811558)", "pathway_count": 32, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6SMK2", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0051781 positive regulation of cell division;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4R0X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08998-1", "uniprot_id": "SOMA_CHICK", "mass": 24713.0, "length": 216, "protein_name": "Somatotropin", "gene_name": "GH", "organism": "Chicken", "refseq_name": "somatotropin precursor", "refseq_ac": "NP_989690", "gene_names_uniprotkb": "GH", "gene_names_refseq": "GH1; GH; cGH", "protein_names_uniprotkb": "Somatotropin; Growth hormone", "protein_names_refseq": "growth hormone 1; neural retina growth hormone; somatotropin precursor; somatotropin", "tax_id": 9031, "disease": "", "pathway": " (gga:378781); (R-GGA-1170546); (R-GGA-422085); (R-GGA-982772)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12960021;1555772;1975228;27591070;27834851;30484611;3174454;3482121;36232848", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X17618.1, M35609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06140852, SAMN06140853 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X17618.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A novel AluI polymorphism in the fourth intron of the chicken growth hormone gene has been reported., [RefSeq, PubMed]; Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Growth hormone plays an important role in growth control., [UniProtKB, UniProtKB, UniProtKB]; There is a negative glucocorticoid response-like element located in the +591/+609 region within the first intron of chicken growth hormone (cGH), which is essential for the down-regulation of cGH expression. Publication Status: Online-Only, [RefSeq, PubMed]; This is the first study to demonstrate that single nucleotide polymorphisms in GHSR can increase appetite, growth traits, expression and level of GHRL, suggesting a hunger signal role for endogenous GHRL., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53Z10", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity;GO:0005131 growth hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050691 regulation of defense response to virus by host;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P08998-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AYC9-1", "uniprot_id": "CHK1_CHICK", "mass": 53849.0, "length": 476, "protein_name": "Serine/threonine-protein kinase Chk1", "gene_name": "CHEK1", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase Chk1", "refseq_ac": "NP_989676", "gene_names_uniprotkb": "CHEK1; CHK1", "gene_names_refseq": "CHEK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase Chk1; 2.7.11.1; CHK1 checkpoint homolog; Checkpoint kinase-1", "protein_names_refseq": "CHK1 checkpoint homolog; STT3, subunit of the oligosaccharyltransferase complex, homolog A; integral membrane protein 1; serine/threonine-protein kinase Chk1", "tax_id": 9031, "disease": "", "pathway": " (gga:374260); (R-GGA-1433557); (R-GGA-176187); (R-GGA-217106); (R-GGA-351433); (R-GGA-351451); (R-GGA-5693607); (R-GGA-5693616); (R-GGA-69473); (R-GGA-69601); (R-GGA-8953750)", "pathway_count": 11, "publication_count": 18, "publication_id_list": "10449415;11062235;12422221;12554671;15059890;15066121;15311285;15800615;17123873;17276342;17404511;17468739;17515904;17575048;26165835;26324327;30787154;9008167", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF525027.1, SRR13267657.7804.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000341.1. On Dec 9, 2006 this sequence version replaced XP_001231582.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; BRCA1 promotes G2 arrest and cell death by prolonging phosphorylation of Chk1 on serine 345 after DNA damage to sustain arrest., [RefSeq, PubMed]; Chk1-dependent centrosome amplification in response to DNA alkylation damage., [RefSeq, PubMed]; Inhibition of checkpoint kinase 1 (Chk1) by RNA-mediated interference or drug treatment suppressed DNA-damage-induced centrosome amplification., [RefSeq, PubMed]; Pericentriolar material expansion depended on CHK1 kinase. Nuclear CHK1 activation after DNA damage mirrored PCM expansion, suggesting a PCM/damage feedback loop whereby CHK1 regulates pericentrin-dependent PCM expansion to control its own activation., [RefSeq, PubMed]; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:12554671). May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. This inhibits their activity through proteasomal degradation, nucleo-cytoplasmic shuttling and inhibition by proteins of the 13-3-3 family. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May promote DNA repair, regulate chromatin assembly and the transcription of genes that regulate cell-cycle progression. May also play a role in replication fork maintenance (By similarity)., [UniProtKB, PubMed, UniProtKB]; These results suggest a mechanism through which Chk1 could protect against tumorigenesis through its role in spindle checkpoint signaling., [RefSeq, PubMed]; These results suggest that MDV disables the ATR-Chk1 pathway through STAT3 activation to benefit its replication. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.3.1.48;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;5.6.2.4;3.1.-.-;2.7.11.26;5.6.2.1;2.7.1.150;2.1.1.-;3.6.4.12;2.3.2.27;3.1.3.48;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;3.6.4.-;2.7.10.1;5.6.2.3;2.7.11.11", "go_molecular_function": "GO:0035402 histone H3T11 kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006974 DNA damage response;GO:0042770 signal transduction in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8AYC9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09481-1", "uniprot_id": "ACHA3_CHICK", "mass": 57028.0, "length": 496, "protein_name": "Neuronal acetylcholine receptor subunit alpha-3", "gene_name": "CHRNA3", "organism": "Chicken", "refseq_name": "neuronal acetylcholine receptor subunit alpha-3 precursor", "refseq_ac": "NP_989747", "gene_names_uniprotkb": "CHRNA3", "gene_names_refseq": "CHRNA3", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-3", "protein_names_refseq": "cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; neuronal acetylcholine receptor subunit alpha-3 precursor; neuronal acetylcholine receptor subunit alpha-3", "tax_id": 9031, "disease": "", "pathway": " (gga:386578); (R-GGA-629587); (R-GGA-629594); (R-GGA-629597)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "1698777;18407517;20592206;3267226", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M37336.1, SRR13267659.314321.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000245.1. On Dec 16, 2004 this sequence version replaced XP_425061.1., [RefSeq]; APC interaction with microtubule plus-end binding protein EB1 is required for alpha3(*)nAChR surface membrane insertion and stabilization, [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (By similarity). CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 (By similarity). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (By similarity). CHRNA3:CHRNB4 also plays an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through extracellular influx and basal ATP release (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NAChR alpha3 and alpha7 lateral mobility is controlled by domain specific, receptor subtype dependent, and cell-type constrained mechanisms; this system could tailor nicotinic signaling capabilities to specific needs of individual locations, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0046872 metal ion binding;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0007399 nervous system development;GO:0035094 response to nicotine;GO:0035095 behavioral response to nicotine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09481-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NZ15-1", "uniprot_id": "F1NZ15_CHICK", "mass": 51985.0, "length": 466, "protein_name": "Hepatocyte nuclear factor 4 alpha", "gene_name": "HNF4A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HNF4A", "gene_names_refseq": "", "protein_names_uniprotkb": "Hepatocyte nuclear factor 4 alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-383280)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NZ15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1BQH1-1", "uniprot_id": "E1BQH1_CHICK", "mass": 64850.0, "length": 579, "protein_name": "Folliculin", "gene_name": "FLCN", "organism": "Chicken", "refseq_name": "folliculin", "refseq_ac": "XP_414807", "gene_names_uniprotkb": "FLCN", "gene_names_refseq": "FLCN", "protein_names_uniprotkb": "Folliculin", "protein_names_refseq": "folliculin", "tax_id": 9031, "disease": "", "pathway": " (gga:416503); (R-GGA-9639288)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052545.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_414807.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0032008 positive regulation of TOR signaling;GO:0009968 negative regulation of signal transduction;GO:1904263 positive regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BQH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84173-1", "uniprot_id": "PHB1_CHICK", "mass": 29896.0, "length": 272, "protein_name": "Prohibitin 1", "gene_name": "PHB1; PHB", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PHB1; PHB; PHB", "gene_names_refseq": "", "protein_names_uniprotkb": "Prohibitin 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5673000); (R-GGA-8949664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16287166", "class_list": "", "function": "In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan., [UniProtKB, UniProtKB]; In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses., [UniProtKB, UniProtKB]; In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0001851 complement component C3b binding;GO:0001850 complement component C3a binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0007005 mitochondrion organization;GO:0032740 positive regulation of interleukin-17 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P84173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0ZYA6-1", "uniprot_id": "A0A8V0ZYA6_CHICK", "mass": 56575.0, "length": 496, "protein_name": "Hepatic triacylglycerol lipase", "gene_name": "LIPC", "organism": "Chicken", "refseq_name": "hepatic triacylglycerol lipase isoform X1", "refseq_ac": "XP_025009786", "gene_names_uniprotkb": "LIPC", "gene_names_refseq": "LIPC", "protein_names_uniprotkb": "Hepatic triacylglycerol lipase; 3.1.1.32; 3.1.1.3; 3.1.1.5; Lipase member C; Lysophospholipase; Phospholipase A1", "protein_names_refseq": "hepatic triacylglycerol lipase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427495); (R-GGA-8963889)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_025009786.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.2.22;3.1.1.32;3.1.1.3;3.1.1.23;3.1.1.79;3.1.1.5;3.1.1.4;3.5.1.1;3.1.1.47;3.1.1.116;3.1.1.-;3.1.1.6;3.1.1.34;3.1.-.-", "go_molecular_function": "GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008970 phospholipase A1 activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0034364 high-density lipoprotein particle;GO:0005615 extracellular space", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0006633 fatty acid biosynthetic process;GO:0034374 low-density lipoprotein particle remodeling;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0ZYA6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76KB1-1", "uniprot_id": "HS2ST_CHICK", "mass": 41702.0, "length": 356, "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "gene_name": "HS2ST1", "organism": "Chicken", "refseq_name": "heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": "NP_989812", "gene_names_uniprotkb": "HS2ST1; HS2ST", "gene_names_refseq": "2-OST; 2OST; CHS2ST; HS2ST1; HS2ST", "protein_names_uniprotkb": "Heparan sulfate 2-O-sulfotransferase 1; 2-O-sulfotransferase; 2-OST; 2.8.2.-; 2OST; HS 2-O-sulfotransferase; Heparan sulfate 2-sulfotransferase; cHS2ST", "protein_names_refseq": "2-O-sulfotransferase; HS 2-O-sulfotransferase; heparan sulfate 2-O-sulfotransferase 1; heparan sulfate 2-sulfotransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:395140); (R-GGA-2022928)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14660620;19022906;24652287", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB093516.1, SRR13267659.82566.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA3109053 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000239.1., [RefSeq]; Catalyzes the transfer of a sulfo group from 3'-phospho-5'-adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis., [UniProtKB, PubMed]; Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase., [RefSeq, PubMed]; Results report the homotrimeric crystal structure of 2OST from chicken, in complex with 3'-phosphoadenosine 5'-phosphate, and identify amino acid residues that are responsible for substrate specificity., [RefSeq, PubMed]; Study showed that one heparan sulfate 2-O-sulfotransferase (HS2ST) and two isoforms of heparan sulfate 6-O-sulfotransferase (HS6ST-1 and -2) occurred in chick embryos and showed where the transcripts were distributed throughout the limb bud, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0042802 identical protein binding;GO:0004394 heparan sulfate 2-sulfotransferase activity;GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q76KB1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V1A8Z1-1", "uniprot_id": "A0A8V1A8Z1_CHICK", "mass": 57120.0, "length": 532, "protein_name": "Sterol carrier protein 2", "gene_name": "SCP2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SCP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sterol carrier protein 2; 2.3.1.155; 2.3.1.16; 2.3.1.176; Acetyl-CoA C-myristoyltransferase; Non-specific lipid-transfer protein; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; Sterol carrier protein X", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-193368); (R-GGA-2046106); (R-GGA-389887); (R-GGA-9033241)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;1.14.13.39;4.1.3.4;4.1.2.63;2.3.1.137;4.1.1.9;3.6.1.77;5.3.3.21;2.3.1.42;3.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.2.27;3.4.24.56;1.3.1.38;3.4.21.-;1.1.1.42;1.5.3.13;1.11.1.6;1.1.3.15;2.6.1.51;2.6.1.44;1.1.1.35;4.2.1.17;5.3.3.8;2.3.1.176;2.3.1.16;2.3.1.155;2.3.1.7;1.5.3.1;1.5.3.7;2.5.1.18;1.3.1.124;5.1.99.4;3.6.1.-", "go_molecular_function": "GO:0008289 lipid binding;GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity;GO:0070538 oleic acid binding;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0032385 positive regulation of intracellular cholesterol transport;GO:1901373 lipid hydroperoxide transport;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V1A8Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V1A9L0-1", "uniprot_id": "A0A8V1A9L0_CHICK", "mass": 60740.0, "length": 556, "protein_name": "Hedgehog protein", "gene_name": "SHH", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SHH", "gene_names_refseq": "", "protein_names_uniprotkb": "Hedgehog protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5358346); (R-GGA-5362798); (R-GGA-5632681)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product., [UniProtKB, UniProtKB, UniProtKB]; The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016740 transferase activity;GO:0008233 peptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0035295 tube development;GO:0007267 cell-cell signaling;GO:0042127 regulation of cell population proliferation;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V1A9L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04584-1", "uniprot_id": "ZYX_CHICK", "mass": 58538.0, "length": 542, "protein_name": "Zyxin", "gene_name": "ZYX", "organism": "Chicken", "refseq_name": "zyxin", "refseq_ac": "NP_001004386", "gene_names_uniprotkb": "ZYX", "gene_names_refseq": "ZYX", "protein_names_uniprotkb": "Zyxin", "protein_names_refseq": "zyxin", "tax_id": 9031, "disease": "", "pathway": " (gga:418300)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1469049;19211519;23742986", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X69190.1, SRR13267661.27503.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000015.1. On Sep 17, 2004 this sequence version replaced XP_416523.1., [RefSeq]; Adhesion plaque protein. Binds alpha-actinin and the CRP protein. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression., [UniProtKB, PubMed]; The roles of multiple haplotypes of zyxin with resistance to experimental avian coccidiosis are reported., [RefSeq, PubMed]; Thus, zyxin appears to play a role as a regulator of cell migration and differentiation during epithelial-mesenchymal transformation in chicken atrioventricular valve formation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0001725 stress fiber;GO:0005912 adherens junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0007160 cell-matrix adhesion;GO:0043149 stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q04584-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NW06-1", "uniprot_id": "F1NW06_CHICK", "mass": 26259.0, "length": 237, "protein_name": "Tetraspanin", "gene_name": "CD81", "organism": "Chicken", "refseq_name": "CD81 antigen", "refseq_ac": "NP_001025510", "gene_names_uniprotkb": "CD81", "gene_names_refseq": "CD81", "protein_names_uniprotkb": "Tetraspanin", "protein_names_refseq": "CD81 antigen (target of antiproliferative antibody 1); CD81 antigen", "tax_id": 9031, "disease": "", "pathway": " (gga:374256)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851687.1, SRR13267658.4578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06140853 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Sep 23, 2021 this sequence version replaced NP_001025510.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0005178 integrin binding;GO:0015485 cholesterol binding;GO:0001618 virus receptor activity;GO:1990459 transferrin receptor binding", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0097197 tetraspanin-enriched microdomain;GO:0001772 immunological synapse", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0002250 adaptive immune response;GO:1903911 positive regulation of receptor clustering;GO:0031623 receptor internalization;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NW06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17785-1", "uniprot_id": "ANXA2_CHICK", "mass": 38640.0, "length": 339, "protein_name": "Annexin A2", "gene_name": "ANXA2", "organism": "Chicken", "refseq_name": "annexin A2", "refseq_ac": "NP_990682", "gene_names_uniprotkb": "ANXA2; ANX2", "gene_names_refseq": "ANX2; ANXA2P2; ANXA2", "protein_names_uniprotkb": "Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; PAP-IV; Placental anticoagulant protein IV; Protein I; p36", "protein_names_refseq": "PAP-IV; annexin A2 pseudogene 2; annexin A2; annexin II; annexin-2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; p36; placental anticoagulant protein IV; protein I", "tax_id": 9031, "disease": "", "pathway": " (gga:396297); (R-GGA-6798695); (R-GGA-75205); (R-GGA-9860927)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "2143014;2456953;25604889;26221766;2973411;39778369", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01097508.1, HAEK01023137.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000245.1., [RefSeq]; (Microbial infection) Serves as a receptor for Eimeria tenella; mediates parasite invasion through the interaction with E.tenella RON2., [UniProtKB, PubMed]; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity., [UniProtKB]; Chicken Annexin A2 (chANXA2) as a novel receptor for retrovirus ALV-J (avian leukosis virus subgroup J). Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate, for the first time, that binding to Anx2 is beneficial for infectious bursal disease virus infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0008092 cytoskeletal protein binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0031982 vesicle", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0007155 cell adhesion;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway;GO:0032332 positive regulation of chondrocyte differentiation;GO:0051928 positive regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P17785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6QLQ5-1", "uniprot_id": "CTHL1_CHICK", "mass": 16072.0, "length": 148, "protein_name": "Cathelicidin-1", "gene_name": "CATH1; CATHL1", "organism": "Chicken", "refseq_name": "cathelicidin-1 precursor", "refseq_ac": "NP_001001605", "gene_names_uniprotkb": "CATH1; CATHL1; CATH", "gene_names_refseq": "CATH-1; CATH-3; CATH1; CATHL1", "protein_names_uniprotkb": "Cathelicidin-1; CATH-1; Fowlicidin-1", "protein_names_refseq": "cathelicidin antimicrobial peptide; cathelicidin-1 precursor; cathelicidin-3; fowlicidin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:414337); (R-GGA-6798695); (R-GGA-6803157)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15148642;16326712;16817888;17827276;28728035;37605242", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX936022.1, BU106516.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA2812691, SAMEA2812692 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX936022.1. On Aug 30, 2004 this sequence version replaced XP_418513.1., [RefSeq]; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response., [UniProtKB, PubMed, PubMed]; The protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; These current observations suggest that CATH1, -2 and -3 in the vagina are upregulated by IL1B, and CATH3 in the uterus is also upregulated by IL6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2IAM1", "ec_number_list": "", "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0002821 positive regulation of adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6QLQ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08250-1", "uniprot_id": "APOA1_CHICK", "mass": 30680.0, "length": 264, "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "organism": "Chicken", "refseq_name": "apolipoprotein A-I preproprotein", "refseq_ac": "NP_990856", "gene_names_uniprotkb": "APOA1", "gene_names_refseq": "APOA1", "protein_names_uniprotkb": "Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1", "protein_names_refseq": "apo-AI; apoA-I; apolipoprotein A-I preproprotein; apolipoprotein A-I; apolipoprotein A1", "tax_id": 9031, "disease": "", "pathway": " (gga:396536); (R-GGA-114608); (R-GGA-1369062); (R-GGA-2168880); (R-GGA-3000471); (R-GGA-381426); (R-GGA-8957275); (R-GGA-8963888); (R-GGA-8963896); (R-GGA-8964011); (R-GGA-8964058); (R-GGA-9707616); (R-GGA-975634)", "pathway_count": 13, "publication_count": 9, "publication_id_list": "1512510;26549235;27402828;28938763;30932484;3108248;3118875;3126099;6406496", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN210849.1, CN210850.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000341.1. On May 25, 2010 this sequence version replaced XP_423364.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Mycoplasma gallisepticum surface lipoprotein pMGA interacts with host APOA1 during infection in chicken., [RefSeq, PubMed]; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT)., [UniProtKB]; The expression level of apoA I in group 2 (diseased) significantly decreased on d 60; the expression level of apoB100 slightly increased on d 30 in group 2, while it sharply decreased on d 60. Compared to group 1 (control), the expression level of apoB100 showed no significant difference in group 3 (protected)., [RefSeq, PubMed]; The transcription of ApoA-I in chicken abdominal adipose tissue was regulated by DNA methylation., [RefSeq, PubMed]; These data suggest that apolipoprotein A-I may participate in a regulatory feedback mechanism with retinoic acid to control the action of retinoic acid on ocular targets during postnatal ocular growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0019899 enzyme binding;GO:0034191 apolipoprotein A-I receptor binding;GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0030139 endocytic vesicle;GO:0034361 very-low-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle", "go_biological_process": "GO:1901247 negative regulation of lung ciliated cell differentiation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P08250-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2LMP1-1", "uniprot_id": "WNT3A_CHICK", "mass": 39629.0, "length": 352, "protein_name": "Protein Wnt-3a", "gene_name": "WNT3A", "organism": "Chicken", "refseq_name": "protein Wnt-3a isoform 1 precursor", "refseq_ac": "NP_001165072", "gene_names_uniprotkb": "WNT3A", "gene_names_refseq": "WNT-3A; WNT3A", "protein_names_uniprotkb": "Protein Wnt-3a", "protein_names_refseq": "Protein Wnt; Wnt-3a homolog; protein Wnt-3a isoform 1 precursor; protein Wnt-3a; wingless-type MMTV integration site family member 3a; wingless-type MMTV integration site family, member 3A", "tax_id": 9031, "disease": "", "pathway": " (gga:395396); (R-GGA-201681); (R-GGA-3238698); (R-GGA-4641262); (R-GGA-4641263); (R-GGA-9856649)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "11142678;11290326;16258938;17488271;22046319;22898776;24599775;24808138;7577679", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ022307.1, EF068232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992527, SAMEA103992648 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000035.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Also enhances FGF8 activity while inhibiting BMP5 and WNT3a signaling, [RefSeq, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:17488271). Regulates chick apical ectodermal ridge formation (PubMed:17488271). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results identify FZD10 as a receptor for WNT1 and WNT3A in the developing chick spinal cord., [RefSeq, PubMed]; SMAD1 has a role in migration of cardiac progenitor cells by integrating BMP2 and Wnt3a signals, [RefSeq, PubMed]; Studied Wnt3a expression patterns in chick embryo nervous system, [RefSeq, PubMed]; WNT3A up-regulates WNT/CTNNB1 signaling and regulates FGF signaling during embryonic limb development, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9PWH1", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding;GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0042472 inner ear morphogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q2LMP1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67970-1", "uniprot_id": "INS_CHICK", "mass": 11981.0, "length": 107, "protein_name": "Insulin", "gene_name": "INS", "organism": "Chicken", "refseq_name": "insulin preproinsulin precursor", "refseq_ac": "NP_990553", "gene_names_uniprotkb": "INS", "gene_names_refseq": "INS", "protein_names_uniprotkb": "Insulin", "protein_names_refseq": "insulin 2; insulin preproinsulin precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396145); (R-GGA-264876); (R-GGA-422085); (R-GGA-6807878); (R-GGA-74713); (R-GGA-74749); (R-GGA-74751); (R-GGA-74752); (R-GGA-77387)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "24094087;5949593;7388949", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX278627.4, BX278628.4 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992544, SAMN03376184 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 14532130 ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1, X58993.1 and BX278627.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that insulin signaling in skeletal muscle can be regulated by dietary factors (here, dietary content of omega-3 fatty acids)., [RefSeq, PubMed]; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01332;Q53YX4", "ec_number_list": "", "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0003407 neural retina development;GO:0008283 cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P67970-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJL9-1", "uniprot_id": "SAMH1_CHICK", "mass": 70233.0, "length": 614, "protein_name": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "gene_name": "SAMHD1", "organism": "Chicken", "refseq_name": "deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "refseq_ac": "NP_001026016", "gene_names_uniprotkb": "SAMHD1; RCJMB04_17d8", "gene_names_refseq": "SAMHD1", "protein_names_uniprotkb": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; 3.1.5.-; dNTPase", "protein_names_refseq": "SAM domain and HD domain 1; SAM domain and HD domain-containing protein 1; dNTPase; deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "tax_id": 9031, "disease": "", "pathway": " (gga:419125); (R-GGA-8956319)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15592404;15642098;27131778", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720415.1, SRR13267654.161795.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. On Sep 23, 2021 this sequence version replaced NP_001026016.1., [RefSeq]; For the first time, chicken SAMHD1 (101-614) was found to possess dNTPase cleavage activities in vitro. This suggests that chicken SAMHD1 may be a potential antiviral factor against avian viruses., [RefSeq, PubMed]; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1P0T3", "ec_number_list": "3.1.5.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005654 nucleoplasm;GO:0097197 tetraspanin-enriched microdomain", "go_biological_process": "GO:0045087 innate immune response;GO:0051289 protein homotetramerization;GO:0051607 defense response to virus;GO:0006203 dGTP catabolic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZJL9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V1A248-1", "uniprot_id": "A0A8V1A248_CHICK", "mass": 79468.0, "length": 724, "protein_name": "Peroxisomal bifunctional enzyme", "gene_name": "EHHADH", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EHHADH", "gene_names_refseq": "", "protein_names_uniprotkb": "Peroxisomal bifunctional enzyme; 1.1.1.35; 4.2.1.17; 5.3.3.8; Multifunctional enzyme 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-390247); (R-GGA-9033241)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;1.14.13.39;4.1.3.4;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;4.1.2.63;2.3.1.137;4.1.1.9;3.6.1.77;5.3.3.21;2.3.1.42;4.2.1.17;1.1.1.211;3.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;5.3.3.8;2.3.2.27;3.4.24.56;1.3.1.38;3.4.21.-;1.1.1.42;1.5.3.13;1.11.1.6;1.1.3.15;2.6.1.51;2.6.1.44;2.3.1.176;2.3.1.16;2.3.1.155;2.3.1.7;1.5.3.1;1.5.3.7;2.5.1.18;1.3.1.124;5.1.99.4;3.6.1.-", "go_molecular_function": "GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0019899 enzyme binding;GO:0070403 NAD+ binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V1A248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V1A683-1", "uniprot_id": "A0A8V1A683_CHICK", "mass": 50899.0, "length": 458, "protein_name": "Choline/ethanolaminephosphotransferase 1", "gene_name": "CEPT1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CEPT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline/ethanolaminephosphotransferase 1; 1-alkenyl-2-acylglycerol choline phosphotransferase; 2.7.8.1; 2.7.8.22; 2.7.8.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421152); (R-GGA-1483191); (R-GGA-1483213)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.8.1;2.7.8.2;2.7.8.22", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity;GO:0004307 ethanolaminephosphotransferase activity;GO:0047359 1-alkenyl-2-acylglycerol choline phosphotransferase activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V1A683-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50147-1", "uniprot_id": "GNAI2_CHICK", "mass": 40577.0, "length": 355, "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-2", "gene_name": "GNAI2", "organism": "Chicken", "refseq_name": "guanine nucleotide-binding protein G(i) subunit alpha-2", "refseq_ac": "NP_990733", "gene_names_uniprotkb": "GNAI2", "gene_names_refseq": "GNAI2", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(i) subunit alpha-2; Adenylate cyclase-inhibiting G alpha protein", "protein_names_refseq": "Gi2 protein alpha-subunit; adenylate cyclase-inhibiting G alpha protein; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2; guanine nucleotide-binding protein G(i) subunit alpha-2", "tax_id": 9031, "disease": "", "pathway": " (gga:396367); (R-GGA-170670); (R-GGA-392170); (R-GGA-418594); (R-GGA-9009391)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "7821803", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01071763.1, HAEL01006261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992484, SAMN05341171 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000252.1. On Jan 17, 2016 this sequence version replaced XP_015148982.1., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030496 midbody", "go_biological_process": "GO:0001525 angiogenesis;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0051301 cell division;GO:0007214 gamma-aminobutyric acid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZK40-1", "uniprot_id": "SNF5_CHICK", "mass": 44496.0, "length": 386, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "gene_name": "SMARCB1", "organism": "Chicken", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "refseq_ac": "NP_001034344", "gene_names_uniprotkb": "SMARCB1; RCJMB04_13f19", "gene_names_refseq": "MMP11; SMARCB1", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1", "protein_names_refseq": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3)", "tax_id": 9031, "disease": "", "pathway": " (gga:769489); (R-GGA-3214858); (R-GGA-8939243); (R-GGA-9933937); (R-GGA-9933939); (R-GGA-9933946); (R-GGA-9934037)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720244.1, HAEK01158616.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ720244.1. On Jan 31, 2006 this sequence version replaced XP_415225.1., [RefSeq]; Involved in chromatin-remodeling. Core component of the BAF (SWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0030957 Tat protein binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0001650 fibrillar center", "go_biological_process": "GO:1902661 positive regulation of glucose mediated signaling pathway;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZK40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28238-1", "uniprot_id": "MIP_CHICK", "mass": 27072.0, "length": 262, "protein_name": "Lens fiber major intrinsic protein", "gene_name": "MIP", "organism": "Chicken", "refseq_name": "lens fiber major intrinsic protein", "refseq_ac": "NP_989597", "gene_names_uniprotkb": "MIP", "gene_names_refseq": "MIP", "protein_names_uniprotkb": "Lens fiber major intrinsic protein; AQP0; Aquaporin-0; MIP26; MP26", "protein_names_refseq": "AQP0; MIP26; MP26; aquaporin-0; lens fiber major intrinsic protein", "tax_id": 9031, "disease": "", "pathway": " (gga:374124); (R-GGA-432047)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14762116;15802270;21172802;2373168", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY078179.1, DR425840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000490.1., [RefSeq]; Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Interaction between Cx50 and AQP0 enhances the coupling of Cx50 gap junctions through the cell adhesion function of AQP0., [RefSeq, PubMed]; Potential role for MIP(AQP0) in the facilitation of fiber connexins for the formation of gap junctions during lens development., [RefSeq, PubMed]; The Cx45.6-MIP(AQP0) interaction plays a novel unidentified role in lens fibers, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8QFW8", "ec_number_list": "", "go_molecular_function": "GO:0015250 water channel activity;GO:0005212 structural constituent of eye lens;GO:0098631 cell adhesion mediator activity;GO:0015267 channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0006833 water transport;GO:0036438 maintenance of lens transparency", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28238-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C0M5-1", "uniprot_id": "E1C0M5_CHICK", "mass": 153869.0, "length": 1351, "protein_name": "BCR activator of RhoGEF and GTPase", "gene_name": "BCR", "organism": "Chicken", "refseq_name": "breakpoint cluster region protein isoform X1", "refseq_ac": "XP_415244", "gene_names_uniprotkb": "BCR", "gene_names_refseq": "BCR", "protein_names_uniprotkb": "BCR activator of RhoGEF and GTPase", "protein_names_refseq": "breakpoint cluster region protein isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8980692); (R-GGA-9013026); (R-GGA-9013106); (R-GGA-9013148); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013423)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052546.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_415244.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0030424 axon;GO:0043197 dendritic spine;GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030216 keratinocyte differentiation;GO:0002692 negative regulation of cellular extravasation;GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1C0M5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13127-1", "uniprot_id": "CAZA1_CHICK", "mass": 32960.0, "length": 286, "protein_name": "F-actin-capping protein subunit alpha-1", "gene_name": "CAPZA1", "organism": "Chicken", "refseq_name": "F-actin-capping protein subunit alpha-1", "refseq_ac": "NP_990846", "gene_names_uniprotkb": "CAPZA1", "gene_names_refseq": "CAPZA1", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha-1; Beta-actinin subunit I; CapZ 36/32", "protein_names_refseq": "F-actin-capping protein subunit alpha-1; actin-capping protein (CapZ 36/32) alpha subunit; beta-actinin subunit I; capZ 36/32; capping protein (actin filament) muscle Z-line, alpha 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396521); (R-GGA-879415)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12660160;16895918;18612635;20625546;2341404;2762296", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01005004.1, HAEL01004019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000356.1., [RefSeq]; Actin-capping protein binds to the filament barbed end of myotrophin/V-1, [RefSeq, PubMed]; CARMIL proteins down-regulate CP by affecting its conformational dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0008290 F-actin capping protein complex;GO:0030018 Z disc;GO:0030863 cortical cytoskeleton", "go_biological_process": "GO:0034329 cell junction assembly;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62167-1", "uniprot_id": "NCS1_CHICK", "mass": 21879.0, "length": 190, "protein_name": "Neuronal calcium sensor 1", "gene_name": "NCS1", "organism": "Chicken", "refseq_name": "neuronal calcium sensor 1", "refseq_ac": "NP_990708", "gene_names_uniprotkb": "NCS1; FLUP; FREQ", "gene_names_refseq": "FLUP; FREQ; NCS-1; NCS1", "protein_names_uniprotkb": "Neuronal calcium sensor 1; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein; NCS-1", "protein_names_refseq": "frequenin homolog; frequenin-like protein; frequenin-like ubiquitous protein; neuronal calcium sensor 1; neuronal calcium sensor homologue", "tax_id": 9031, "disease": "", "pathway": " (gga:396336)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19368896;7488079;8903951", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01010264.1, HAEK01170436.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000308.1. On Dec 8, 2021 this sequence version replaced XP_015134825.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Findings suggest that NCS-1 is involved in the regulation of both neurite outgrowth and growth cone morphology; in addition, NCS-1 is functionally linked to InsP(3)R1, which may play an important role in the regulation of neurite outgrowth, [RefSeq, PubMed]; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P36610;Q9UK26", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0010975 regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "H9KZZ1-1", "uniprot_id": "H9KZZ1_CHICK", "mass": 88644.0, "length": 790, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "NTRK1", "organism": "Chicken", "refseq_name": "high affinity nerve growth factor receptor precursor", "refseq_ac": "NP_990709", "gene_names_uniprotkb": "NTRK1", "gene_names_refseq": "CTRKA; NTRK1; trkA", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "high affinity nerve growth factor receptor precursor; high affinity nerve growth factor receptor; neurotrophic tyrosine kinase, receptor, type 1; trk-A; tropomyosin receptor kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:396337); (R-GGA-1257604); (R-GGA-170968); (R-GGA-170984); (R-GGA-177504); (R-GGA-187042); (R-GGA-198203)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "26945060;30165176", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U43396.1, X93581.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051, SAMN06140853 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000349.1. On Oct 4, 2021 this sequence version replaced NP_990709.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Our results suggest that TrkA activation may play an important role in the survival of OT neurons subjected to acute hypoxia., [RefSeq, PubMed]; These findings suggest that by interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;3.6.5.2;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005030 neurotrophin receptor activity;GO:0048406 nerve growth factor binding;GO:0043121 neurotrophin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0046579 positive regulation of Ras protein signal transduction;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "H9KZZ1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZMT0-1", "uniprot_id": "1433E_CHICK", "mass": 29174.0, "length": 255, "protein_name": "14-3-3 protein epsilon", "gene_name": "YWHAE", "organism": "Chicken", "refseq_name": "14-3-3 protein epsilon", "refseq_ac": "NP_001006219", "gene_names_uniprotkb": "YWHAE; RCJMB04_1e8", "gene_names_refseq": "YWHAE", "protein_names_uniprotkb": "14-3-3 protein epsilon; 14-3-3E", "protein_names_refseq": "14-3-3 protein epsilon; 14-3-3E; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide", "tax_id": 9031, "disease": "", "pathway": " (gga:417554); (R-GGA-2028269); (R-GGA-2565942); (R-GGA-3371453); (R-GGA-3371511); (R-GGA-380259); (R-GGA-380270); (R-GGA-380284); (R-GGA-380320); (R-GGA-5620912); (R-GGA-5628897); (R-GGA-8854518); (R-GGA-8876198)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "15642098;16287166", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000966.1, HAEL01000434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1. On Nov 22, 2004 this sequence version replaced XP_415801.1., [RefSeq]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P84171", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0015459 potassium channel regulator activity;GO:0031625 ubiquitin protein ligase binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0007165 signal transduction;GO:0000165 MAPK cascade;GO:0034605 cellular response to heat;GO:0046827 positive regulation of protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZMT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZM91-1", "uniprot_id": "KAP0_CHICK", "mass": 43350.0, "length": 382, "protein_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "gene_name": "PRKAR1A", "organism": "Chicken", "refseq_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "refseq_ac": "NP_001007846", "gene_names_uniprotkb": "PRKAR1A; RCJMB04_2n5", "gene_names_refseq": "PRKAR1A", "protein_names_uniprotkb": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type I-alpha regulatory subunit; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)", "tax_id": 9031, "disease": "", "pathway": " (gga:417438); (R-GGA-163615); (R-GGA-164378); (R-GGA-180024); (R-GGA-432040); (R-GGA-442720); (R-GGA-5610787); (R-GGA-9634597); (R-GGA-983231); (R-GGA-9856530)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "15642098;17376427;21876332", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719493.1, HAEK01010493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000317.1. On Dec 15, 2004 this sequence version replaced XP_415689.1., [RefSeq]; In chicken brain PKA RI aggregates were detected first in the olfactory bulb, around embryonic day 14; within 3 days they appeared in the hyperpallium and nidopallium, where the most intense labeling was observed in the perihatching period, [RefSeq, PubMed]; Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0019904 protein domain specific binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0031625 ubiquitin protein ligase binding;GO:0030552 cAMP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0071377 cellular response to glucagon stimulus;GO:0046007 negative regulation of activated T cell proliferation;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZM91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZMQ2-1", "uniprot_id": "ACTG_CHICK", "mass": 41793.0, "length": 375, "protein_name": "Actin, cytoplasmic 2", "gene_name": "ACTG1", "organism": "Chicken", "refseq_name": "actin, cytoplasmic 2", "refseq_ac": "NP_001295542", "gene_names_uniprotkb": "ACTG1; RCJMB04_1h13", "gene_names_refseq": "ACTC2L; ACTG1", "protein_names_uniprotkb": "Actin, cytoplasmic 2; 3.6.4.-; Gamma-actin", "protein_names_refseq": "actin, cytoplasmic 2-like; actin, cytoplasmic 2; gamma-actin; type 5 nonmuscle actin", "tax_id": 9031, "disease": "", "pathway": " (gga:776816); (R-GGA-190873); (R-GGA-196025); (R-GGA-2029482); (R-GGA-3928662); (R-GGA-3928665); (R-GGA-418990); (R-GGA-437239); (R-GGA-4420097); (R-GGA-5626467); (R-GGA-5663213); (R-GGA-5663220); (R-GGA-5674135); (R-GGA-8856828); (R-GGA-9013418); (R-GGA-9764561); (R-GGA-9953170); (R-GGA-9958825)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719332.1, HAEK01023736.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000317.1. On or before Jul 6, 2018 this sequence version replaced XP_015135388.1, XP_001236316.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;2.7.11.1;5.6.1.6;5.6.2.4;3.1.3.36;3.6.4.10;3.6.4.12;5.6.2.3;2.7.10.1;2.7.4.3;4.2.99.18;7.2.2.-;3.1.3.86;3.1.3.56;2.3.2.27;3.6.5.5;3.6.5.-;3.6.5.2;2.7.10.2;3.6.4.-;3.1.-.-;5.6.2.-;2.7.11.24;2.7.7.7;2.7.7.49;2.3.2.26;3.1.3.1;3.6.1.15;3.1.27.-;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding;GO:0098973 structural constituent of postsynaptic actin cytoskeleton;GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0007409 axonogenesis;GO:0048870 cell motility;GO:0051893 regulation of focal adhesion assembly;GO:0120192 tight junction assembly;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMQ2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67966-1", "uniprot_id": "CSRP1_CHICK", "mass": 20385.0, "length": 192, "protein_name": "Cysteine and glycine-rich protein 1", "gene_name": "CSRP1", "organism": "Chicken", "refseq_name": "cysteine and glycine-rich protein 1", "refseq_ac": "NP_990579", "gene_names_uniprotkb": "CSRP1; CSRP", "gene_names_refseq": "CSRP1; CSRP", "protein_names_uniprotkb": "Cysteine and glycine-rich protein 1; CRP1; CRP; Cysteine-rich protein 1", "protein_names_refseq": "CRP1; CRP; cysteine and glycine-rich protein 1; cysteine-rich protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396176)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1469049;16336664;19284992;7499425;7664053;8157637;8294495;8506279", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X73831.1, HAEK01150090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cysteine-rich protein 1 regulates actin filament bundling by directly cross-linking actin filaments and stabilizing the interaction of alpha-actinin with actin filament bundles. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of the genes encoding both CRP1 and CRP2 is differentially regulated in normal versus transformed cells, raising the possibility that members of the CRP family may function in control of cell growth and differentiation., [RefSeq, PubMed]; Heat stable protein, that interacts with zyxin/ZYX. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression., [UniProtKB, PubMed]; These results highlight the importance of the first glycine-rich region for CRP1 bundling activity and localization to the actin cytoskeleton., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P32965", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051219 phosphoprotein binding;GO:0051393 alpha-actinin binding;GO:0008307 structural constituent of muscle;GO:0042805 actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0031252 cell leading edge;GO:0001725 stress fiber", "go_biological_process": "GO:0045214 sarcomere organization;GO:0060537 muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P67966-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V1AKX1-1", "uniprot_id": "A0A8V1AKX1_CHICK", "mass": 281743.0, "length": 2575, "protein_name": "Fatty acid synthase", "gene_name": "FASN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FASN", "gene_names_refseq": "", "protein_names_uniprotkb": "Fatty acid synthase; 1.1.1.100; 1.3.1.39; 2.3.1.38; 2.3.1.39; 2.3.1.41; 2.3.1.85; 3.1.2.14; 4.2.1.59", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-199220); (R-GGA-75105)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.39;2.7.8.7;1.1.1.100;1.3.1.39;2.3.1.38;2.3.1.41;2.3.1.85;3.1.2.14;4.2.1.59", "go_molecular_function": "GO:0031177 phosphopantetheine binding;GO:0004312 fatty acid synthase activity;GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity;GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity;GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042587 glycogen granule", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0008611 ether lipid biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0030224 monocyte differentiation;GO:0044788 host-mediated perturbation of viral process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V1AKX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0AVX7-1", "uniprot_id": "CHP3_CHICK", "mass": 25051.0, "length": 214, "protein_name": "Calcineurin B homologous protein 3", "gene_name": "TESC", "organism": "Chicken", "refseq_name": "calcineurin B homologous protein 3", "refseq_ac": "NP_001074353", "gene_names_uniprotkb": "TESC; CHP3", "gene_names_refseq": "TESC; TSC", "protein_names_uniprotkb": "Calcineurin B homologous protein 3; TSC; Tescalcin", "protein_names_refseq": "calcineurin B homologous protein 3", "tax_id": 9031, "disease": "", "pathway": " (gga:771113)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15590942;19345287", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX931037.1, BU300083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX931037.1. On Jan 30, 2007 this sequence version replaced XP_001234413.1., [RefSeq]; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin (By similarity)., [UniProtKB]; Studies indicate very specific expression of Tesc in various tissues in chicken and mouse during embryologic development, and conservation of Tesc expression in both species., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0004860 protein kinase inhibitor activity;GO:0019212 phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0032587 ruffle membrane", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0033628 regulation of cell adhesion mediated by integrin;GO:0030154 cell differentiation;GO:0071300 cellular response to retinoic acid;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0AVX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0M8T8-1", "uniprot_id": "A0M8T8_CHICK", "mass": 20469.0, "length": 178, "protein_name": "Caveolin", "gene_name": "CAV1", "organism": "Chicken", "refseq_name": "caveolin-1", "refseq_ac": "NP_001099134", "gene_names_uniprotkb": "CAV1", "gene_names_refseq": "CAV1; caveolin-1", "protein_names_uniprotkb": "Caveolin", "protein_names_refseq": "caveolin 1, caveolae protein, 22kDa; caveolin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:373996); (R-GGA-209968); (R-GGA-210991); (R-GGA-4641262); (R-GGA-8980692); (R-GGA-9009391); (R-GGA-9013026); (R-GGA-9013106); (R-GGA-9013148); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013406); (R-GGA-9013407); (R-GGA-9013408); (R-GGA-9013423); (R-GGA-9035034); (R-GGA-9696264); (R-GGA-9696270)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "28914464", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.69984.1, HAEK01081879.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992470, SAMEA3109053 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Sep 23, 2021 this sequence version replaced NP_001099134.1., [RefSeq]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity., [UniProtKB, UniProtKB]; The presence of Cav-1 and cholesterol in secretory cells indicates, that the bursa is a complex organ in addition to possessing immunological function contributes to the cholesterol homeostasis in the chickens., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1P039", "ec_number_list": "", "go_molecular_function": "GO:0070320 inward rectifier potassium channel inhibitor activity;GO:0060090 molecular adaptor activity;GO:0008142 oxysterol binding;GO:0005102 signaling receptor binding;GO:0016504 peptidase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005925 focal adhesion", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0072584 caveolin-mediated endocytosis;GO:1900027 regulation of ruffle assembly;GO:2000535 regulation of entry of bacterium into host cell;GO:1901380 negative regulation of potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0M8T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A3R064-1", "uniprot_id": "DOK3_CHICK", "mass": 47167.0, "length": 426, "protein_name": "Docking protein 3", "gene_name": "DOK3", "organism": "Chicken", "refseq_name": "docking protein 3 isoform X2", "refseq_ac": "XP_046756390", "gene_names_uniprotkb": "DOK3", "gene_names_refseq": "DOK3", "protein_names_uniprotkb": "Docking protein 3; Downstream of tyrosine kinase 3", "protein_names_refseq": "docking protein 3 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:429960); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17290227", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Plays a role as negative regulator of the mobilization of calcium ions and of calcium signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A3R064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A5HNF6-1", "uniprot_id": "MYD88_CHICK", "mass": 33781.0, "length": 299, "protein_name": "Myeloid differentiation primary response protein MyD88", "gene_name": "MYD88", "organism": "Chicken", "refseq_name": "myeloid differentiation primary response protein MyD88", "refseq_ac": "NP_001026133", "gene_names_uniprotkb": "MYD88; RCJMB04_14h3", "gene_names_refseq": "MYD88", "protein_names_uniprotkb": "Myeloid differentiation primary response protein MyD88", "protein_names_refseq": "myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88", "tax_id": 9031, "disease": "", "pathway": " (gga:420420); (R-GGA-433822); (R-GGA-451477); (R-GGA-451514); (R-GGA-573298); (R-GGA-977240)", "pathway_count": 6, "publication_count": 23, "publication_id_list": "11460167;11923871;11960013;12447442;12609980;12855817;14625308;14633987;15642098;16260493;17135271;17496917;17676477;17878161;18070982;18438411;18582498;19224918;19675569;19898473;23352867;36805927;37019074", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851640.1, HAEK01016323.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000035.1. On Sep 23, 2021 this sequence version replaced NP_001026133.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response., [UniProtKB, PubMed]; MyD88 gene expression was detected in each tissue tested except in muscle., [RefSeq, PubMed]; Over-expression of chicken isoform 2 significantly induces activation of NF-kappaB in vitro; chicken MyD88-2 may play an important role in chicken innate immune responses., [RefSeq, PubMed]; Regulation of the MyD88 gene in chicken spleen inflammation induced by stress., [RefSeq, PubMed]; The anti-inflammatory effect of lutein in broilers is mediated by regulating Toll-like receptor 4/myeloid-differentiation-factor 88 signaling pathway., [RefSeq, PubMed]; The results demonstrated that ChTLR4, ChTLR15 and MyD88 were involved in E. tenella sporozoites recognition and subsequent signal transduction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0FIQ0;Q5F3L0", "ec_number_list": "", "go_molecular_function": "GO:0035325 Toll-like receptor binding;GO:0070976 TIR domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "A5HNF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B3TP03-1", "uniprot_id": "CTR2_CHICK", "mass": 71216.0, "length": 654, "protein_name": "Cationic amino acid transporter 2", "gene_name": "SLC7A2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC7A2; ATRC2; CAT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cationic amino acid transporter 2; CAT-2; CAT2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2; cCAT-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "18495509", "class_list": "", "function": "Low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B3TP04;B3TP05", "ec_number_list": "", "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0097638 L-arginine import across plasma membrane;GO:0097639 L-lysine import across plasma membrane;GO:1903352 L-ornithine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B3TP03-1", "record_type": "protein" }, { "uniprot_canonical_ac": "B6ZLK2-1", "uniprot_id": "CHD1_CHICK", "mass": 197526.0, "length": 1719, "protein_name": "ATP-dependent chromatin remodeler CHD1", "gene_name": "CHD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHD1", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD1; 3.6.4.-; CHD-1; Chromo domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19625449", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome. Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity). Required for centromeric localization of CENPA (PubMed:19625449)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B6ZLK2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "C4PCF3-1", "uniprot_id": "C4PCF3_CHICK", "mass": 95641.0, "length": 843, "protein_name": "Toll-like receptor 4", "gene_name": "TLR4", "organism": "Chicken", "refseq_name": "toll-like receptor 4 precursor", "refseq_ac": "NP_001025864", "gene_names_uniprotkb": "TLR4", "gene_names_refseq": "TLR4", "protein_names_uniprotkb": "Toll-like receptor 4", "protein_names_refseq": "toll-like receptor 4 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:417241); (R-GGA-140534); (R-GGA-166016); (R-GGA-166166); (R-GGA-2562578); (R-GGA-5686938); (R-GGA-936964); (R-GGA-937041); (R-GGA-937072); (R-GGA-9707616); (R-GGA-975163); (R-GGA-9824878)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "18768894;19046776;21607608;30532755;30646748;34866215;37019074", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: KP410249.1, KF421486.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000308.1. On Sep 23, 2021 this sequence version replaced NP_001025864.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Chickens sense lipopolysaccharide via orthologs of mammalian TLR4 rather than via the previously implicated chicken TLR2 isoform type 2 receptor., [RefSeq, PubMed]; From 1 d of age, TLR4 positivity was found in the spleen in diffuse granular form. The cells showing intense TLR4 positivity were observed in periellipsoidal lymphoid tissue in 4-d-old chicks., [RefSeq, PubMed]; Kadaknath breed expressed significantly (P < 0.01) higher levels of TLR4 transcripts than Aseel breed, however there is no significant difference in TLR5 mRNA expression between these two breeds., [RefSeq, PubMed]; TLR2 and TLR4 molecules and antigen-presenting cell compositions in cecal tonsils of broiler chicks (Gallus gallus domesticus) in the first two weeks of the post-hatch period., [RefSeq, PubMed]; The anti-inflammatory effect of lutein in broilers is mediated by regulating Toll-like receptor 4/myeloid-differentiation-factor 88 signaling pathway., [RefSeq, PubMed]; Ulvan may be a new ligand for TLR2 and TLR4; and that they regulate heterophil activation in slightly different manner. Publication Status: Online-Only, [RefSeq, PubMed]; Vaginal tissue expressing TLR4 responds to LPS and in turn upregulates cellular functions to synthesize cytokines. Such expression and functions of TLRs may play an essential role in oviductal innate immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0043032 positive regulation of macrophage activation;GO:0032700 negative regulation of interleukin-17 production;GO:0002246 wound healing involved in inflammatory response;GO:1904466 positive regulation of matrix metallopeptidase secretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "C4PCF3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1BSI0-1", "uniprot_id": "PARP3_CHICK", "mass": 58792.0, "length": 526, "protein_name": "Protein mono-ADP-ribosyltransferase PARP3", "gene_name": "PARP3", "organism": "Chicken", "refseq_name": "protein mono-ADP-ribosyltransferase PARP3", "refseq_ac": "XP_015148336", "gene_names_uniprotkb": "PARP3", "gene_names_refseq": "PARP3", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP3; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 3; ADPRT-3; ARTD3; DNA ADP-ribosyltransferase PARP3; NAD(+) ADP-ribosyltransferase 3; cPARP3", "protein_names_refseq": "protein mono-ADP-ribosyltransferase PARP3", "tax_id": 9031, "disease": "", "pathway": " (gga:771158)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;27530147", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015148336.1. COMPLETENESS: full length., [RefSeq]; Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage (PubMed:27530147). Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6 (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA (PubMed:27530147). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks (By similarity). Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ) (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q2UAE2", "ec_number_list": "2.4.2.-;2.4.2.30", "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity;GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity;GO:0140804 NAD+-protein-lysine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005814 centriole;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006302 double-strand break repair;GO:0051053 negative regulation of DNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BSI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1BSW7-1", "uniprot_id": "CENPS_CHICK", "mass": 15619.0, "length": 139, "protein_name": "Centromere protein S", "gene_name": "CENPS", "organism": "Chicken", "refseq_name": "centromere protein S isoform 1", "refseq_ac": "NP_001191861", "gene_names_uniprotkb": "CENPS; APITD1", "gene_names_refseq": "APITD1; CENP-S; CENPS", "protein_names_uniprotkb": "Centromere protein S; CENP-S", "protein_names_refseq": "apoptosis-inducing, TAF9-like domain 1; centromere protein S isoform 1", "tax_id": 9031, "disease": "", "pathway": " (gga:771417)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12445392;15592404;19620631;20347428;22304917", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01169545.1, HAEK01139556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000329.1. On Mar 17, 2011 this sequence version replaced XP_001234691.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0071821 FANCM-MHF complex;GO:0000776 kinetochore", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006281 DNA repair;GO:0051301 cell division;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E1BSW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1BTG2-1", "uniprot_id": "LMOD2_CHICK", "mass": 62373.0, "length": 552, "protein_name": "Leiomodin-2", "gene_name": "LMOD2", "organism": "Chicken", "refseq_name": "leiomodin-2", "refseq_ac": "NP_001186644", "gene_names_uniprotkb": "LMOD2", "gene_names_refseq": "C-LMOD; LMOD2; leiomodin-2", "protein_names_uniprotkb": "Leiomodin-2; C-LMOD; Cardiac leiomodin", "protein_names_refseq": "cardiac leiomodin; leiomodin 2 (cardiac); leiomodin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:417751)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;20736303", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.13659.1, SRR13267649.122050.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Sep 20, 2021 this sequence version replaced NP_001186644.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length (PubMed:20736303). Required for normal sarcomere organization in the heart, and for normal heart function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Overexpression of Lmod2 results in loss of Tmod1 assembly and elongation of the thin filaments from their pointed ends in cardiac muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005865 striated muscle thin filament;GO:0031430 M band;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030041 actin filament polymerization;GO:0051694 pointed-end actin filament capping;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BTG2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1BUI5-1", "uniprot_id": "E1BUI5_CHICK", "mass": 167991.0, "length": 1583, "protein_name": "Mediator of RNA polymerase II transcription subunit 1", "gene_name": "MED1", "organism": "Chicken", "refseq_name": "mediator of RNA polymerase II transcription subunit 1", "refseq_ac": "XP_418125", "gene_names_uniprotkb": "MED1", "gene_names_refseq": "MED1", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 1; Mediator complex subunit 1", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420004); (R-GGA-383280); (R-GGA-9841922)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052558.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_418125.2. COMPLETENESS: full length., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050693 LBD domain binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016592 mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:2001141 regulation of RNA biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BUI5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C1L6-1", "uniprot_id": "ENTP5_CHICK", "mass": 47961.0, "length": 428, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 5", "gene_name": "ENTPD5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ENTPD5", "gene_names_refseq": "", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 5; 3.6.1.6; GDPase ENTPD5; Guanosine-diphosphatase ENTPD5; NTPDase 5; UDPase ENTPD5; Uridine-diphosphatase ENTPD5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (By similarity). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.5;3.6.1.6;3.1.3.1", "go_molecular_function": "GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:1990003 IDP phosphatase activity;GO:0036384 CDP phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006256 UDP catabolic process;GO:0006487 protein N-linked glycosylation;GO:0006011 UDP-alpha-D-glucose metabolic process;GO:0051084 'de novo' post-translational protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1C1L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C2I2-1", "uniprot_id": "GWL_CHICK", "mass": 97913.0, "length": 881, "protein_name": "Serine/threonine-protein kinase greatwall", "gene_name": "MASTL", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MASTL; GWL; GW", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase greatwall; 2.7.11.1; GWL; GW; MAST-L; Microtubule-associated serine/threonine-protein kinase-like", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (By similarity). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (By similarity). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (By similarity). Following DNA damage, it is also involved in checkpoint recovery by being inhibited., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0051721 protein phosphatase 2A binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0032154 cleavage furrow", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0035556 intracellular signal transduction;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1C2I2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C3P4-1", "uniprot_id": "CBPC1_CHICK", "mass": 137742.0, "length": 1224, "protein_name": "Cytosolic carboxypeptidase 1", "gene_name": "AGTPBP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AGTPBP1; CCP1K", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytosolic carboxypeptidase 1; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein 1; Protein deglutamylase CCP1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.17.24;3.4.17.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006508 proteolysis;GO:0050905 neuromuscular process;GO:0007005 mitochondrion organization;GO:0021702 cerebellar Purkinje cell differentiation;GO:0001754 eye photoreceptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1C3P4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C3U7-1", "uniprot_id": "LOXL2_CHICK", "mass": 86965.0, "length": 774, "protein_name": "Lysyl oxidase homolog 2", "gene_name": "LOXL2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOXL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysyl oxidase homolog 2; 1.4.3.13; Lysyl oxidase-like protein 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3. During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription. SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits. Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction. When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.4.3.13", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:1902455 negative regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001666 response to hypoxia;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1C3U7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "E1C626-1", "uniprot_id": "E1C626_CHICK", "mass": 61915.0, "length": 545, "protein_name": "TNF receptor-associated factor", "gene_name": "TRAF6", "organism": "Chicken", "refseq_name": "TNF receptor-associated factor 6", "refseq_ac": "XP_004941602", "gene_names_uniprotkb": "TRAF6", "gene_names_refseq": "TRAF6", "protein_names_uniprotkb": "TNF receptor-associated factor; 2.3.2.27", "protein_names_refseq": "TNF receptor-associated factor 6", "tax_id": 9031, "disease": "", "pathway": " (gga:423163); (R-GGA-1227882); (R-GGA-1227892); (R-GGA-193692); (R-GGA-202424); (R-GGA-205043); (R-GGA-209543); (R-GGA-209560); (R-GGA-2871837); (R-GGA-433822); (R-GGA-433871); (R-GGA-434001); (R-GGA-434131); (R-GGA-437980); (R-GGA-437986); (R-GGA-450302); (R-GGA-450321); (R-GGA-5607764); (R-GGA-5689880); (R-GGA-5689896); (R-GGA-573298); (R-GGA-9020702); (R-GGA-937042); (R-GGA-937072); (R-GGA-9645460); (R-GGA-975163); (R-GGA-9758274)", "pathway_count": 27, "publication_count": 49, "publication_id_list": "10893229;11057907;11460167;12193592;12221085;12609980;12692549;13130464;14555995;14625308;14633987;15145317;15287722;15371334;15837794;16056267;16115877;16153868;16186825;16260493;16301747;16306937;16858409;16914100;17047224;17135271;17255097;17327220;17332413;17395714;17496917;17526488;17875933;17878161;18070982;18793328;18984593;19224918;19465916;19479062;19666475;19675569;19898473;20097753;8533096;8846784;9195981;9463386;9689078", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;3.4.19.12;3.4.23.-;2.7.11.25;2.7.11.13;2.7.11.10;2.3.2.27;2.7.11.1;3.2.2.6", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0070498 interleukin-1-mediated signaling pathway;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0023035 CD40 signaling pathway;GO:0000045 autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "E1C626-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1N916-1", "uniprot_id": "F1N916_CHICK", "mass": 55187.0, "length": 497, "protein_name": "Beta-secretase 1", "gene_name": "BACE1", "organism": "Chicken", "refseq_name": "beta-secretase 1", "refseq_ac": "XP_015153722", "gene_names_uniprotkb": "BACE1", "gene_names_refseq": "BACE1", "protein_names_uniprotkb": "Beta-secretase 1; 3.4.23.46; Beta-site amyloid precursor protein cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2", "protein_names_refseq": "beta-secretase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:419768)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052555.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PSJ2", "ec_number_list": "", "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0004190 aspartic-type endopeptidase activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0016485 protein processing;GO:0050435 amyloid-beta metabolic process;GO:0043525 positive regulation of neuron apoptotic process;GO:0034205 amyloid-beta formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N916-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NBL0-1", "uniprot_id": "MUC6_CHICK", "mass": 132217.0, "length": 1185, "protein_name": "Mucin-6", "gene_name": "MUC6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MUC6", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucin-6; Ovomucin, beta-subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15592404;21484392;5119791", "class_list": "", "function": "Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6L608", "ec_number_list": "", "go_molecular_function": "GO:0003823 antigen binding;GO:0005201 extracellular matrix structural constituent;GO:0046790 virion binding", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0030299 intestinal cholesterol absorption;GO:0042632 cholesterol homeostasis;GO:0030308 negative regulation of cell growth;GO:0002281 macrophage activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1NBL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NCD6-1", "uniprot_id": "NLS1_CHICK", "mass": 58423.0, "length": 528, "protein_name": "Sodium-dependent lysophosphatidylcholine symporter 1", "gene_name": "MFSD2A", "organism": "Chicken", "refseq_name": "sodium-dependent lysophosphatidylcholine symporter 1", "refseq_ac": "XP_040545862", "gene_names_uniprotkb": "MFSD2A; NLS1", "gene_names_refseq": "MFSD2A", "protein_names_uniprotkb": "Sodium-dependent lysophosphatidylcholine symporter 1; GgMFSD2A; Major facilitator superfamily domain-containing protein 2A; NLS1; Sodium-dependent LPC symporter 1", "protein_names_refseq": "sodium-dependent lysophosphatidylcholine symporter 1", "tax_id": 9031, "disease": "", "pathway": " (gga:419679); (R-GGA-1483191)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15592404;34135507", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052595.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By similarity). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (By similarity). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0051978 lysophospholipid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1990379 lipid transport across blood-brain barrier;GO:0055085 transmembrane transport;GO:0015908 fatty acid transport;GO:0008643 carbohydrate transport;GO:0140329 lysophospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1NCD6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NCX7-1", "uniprot_id": "F1NCX7_CHICK", "mass": 66981.0, "length": 595, "protein_name": "Serine/threonine-protein kinase PLK", "gene_name": "PLK1", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase PLK1", "refseq_ac": "NP_001025810", "gene_names_uniprotkb": "PLK1", "gene_names_refseq": "PLK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK; 2.7.11.21; Polo-like kinase", "protein_names_refseq": "serine/threonine-protein kinase PLK1", "tax_id": 9031, "disease": "", "pathway": " (gga:416575); (R-GGA-141430); (R-GGA-141444); (R-GGA-156711); (R-GGA-162658); (R-GGA-174178); (R-GGA-176412); (R-GGA-176417); (R-GGA-2299718); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-2565942); (R-GGA-2980767); (R-GGA-380259); (R-GGA-380270); (R-GGA-380284); (R-GGA-380320); (R-GGA-5620912); (R-GGA-5663220); (R-GGA-68881); (R-GGA-68884); (R-GGA-8852276); (R-GGA-8854518); (R-GGA-9648025)", "pathway_count": 24, "publication_count": 1, "publication_id_list": "27603133", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720598.1, SRR13267649.226046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1. On Sep 23, 2021 this sequence version replaced NP_001025810.1., [RefSeq]; P17 suppresses both CDK1 and Plk1functions, disrupts vimentin phosphorylation, causes G2/M cell cycle arrest and thus benefits virus replication. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.3.2.23;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;3.1.3.16;3.6.4.12;2.7.11.26;3.6.5.2;2.7.1.150;2.1.1.-;3.4.22.49;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;3.1.3.53;2.7.11.11", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0051233 spindle midzone", "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:1903673 mitotic cleavage furrow formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1NCX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1ND48-1", "uniprot_id": "FBH1_CHICK", "mass": 114957.0, "length": 1012, "protein_name": "F-box DNA helicase 1", "gene_name": "FBH1", "organism": "Chicken", "refseq_name": "F-box DNA helicase 1 isoform 1", "refseq_ac": "NP_001073679", "gene_names_uniprotkb": "FBH1; FBX18; FBXO18", "gene_names_refseq": "FBH1; FBX18; FBXO18", "protein_names_uniprotkb": "F-box DNA helicase 1; 5.6.2.4; DNA 3'-5' helicase 1; F-box only protein 18", "protein_names_refseq": "DNA 3'-5' helicase 1; F-box DNA helicase 1 isoform 1; F-box DNA helicase 1; F-box helicase; F-box only protein 18; F-box only protein, helicase, 18", "tax_id": 9031, "disease": "", "pathway": " (gga:416687)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;17283053", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.73837.1, SRR13267654.94378.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000006.1. On or before Dec 3, 2021 this sequence version replaced XP_015139069.2, NP_001073679.1., [RefSeq]; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17283053). Also promotes cell death and DNA double-strand breakage in response to replication stress: promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress., [UniProtKB, PubMed, UniProtKB]; These data suggest that Fbh1 acts in parallel with Bloom helicase to control recombination-mediated double-strand-break repair at replication blocks and to reduce the frequency of crossover., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1YKW0", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0019005 SCF ubiquitin ligase complex;GO:0000785 chromatin", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1ND48-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NHE9-1", "uniprot_id": "KCJ12_CHICK", "mass": 49083.0, "length": 429, "protein_name": "ATP-sensitive inward rectifier potassium channel 12", "gene_name": "KCNJ12", "organism": "Chicken", "refseq_name": "ATP-sensitive inward rectifier potassium channel 12", "refseq_ac": "NP_001383542", "gene_names_uniprotkb": "KCNJ12", "gene_names_refseq": "KCNJ12; Kir2.2", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 12; Inward rectifier K(+) channel Kir2.2; Potassium channel, inwardly rectifying subfamily J member 12", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 12; inward rectifier K(+) channel Kir2.2; potassium channel, inwardly rectifying subfamily J member 12", "tax_id": 9031, "disease": "", "pathway": " (gga:427662); (R-GGA-1296041); (R-GGA-1296053); (R-GGA-5576886); (R-GGA-997272)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15592404;20019282;21874019;23270460", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.276126.1, SRR12888541.183095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On or before Oct 25, 2021 this sequence version replaced XP_015149865.1, XP_040539314.1., [RefSeq]; Crystal structure of Kir2.2; crystals containing Rb+, Sr2+ & Eu3+ reveal binding sites along ion conduction pathway that are conductive & inhibitory; sites correlate with electrophysiological data & provide structural basis for understanding rectification, [RefSeq, PubMed]; Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium., [UniProtKB, UniProtKB]; Using molecular dynamics simulations, the study predicted the binding site for the anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) on the KCNJ12 inwardly rectifying potassium channel., [RefSeq, PubMed]; X-ray crystal structure of a Kir2.2 channel in complex with a short-chain (dioctanoyl) derivative of PIP(2) [Kir2.2] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D2YW45", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030315 T-tubule;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1NHE9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NHM3-1", "uniprot_id": "F1NHM3_CHICK", "mass": 33147.0, "length": 299, "protein_name": "Myogenic factor", "gene_name": "MYOD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYOD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Myogenic factor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374048); (R-GGA-525793)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0030016 myofibril;GO:0000791 euchromatin", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014904 myotube cell development;GO:0043335 protein unfolding;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NHM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67962-1", "uniprot_id": "KC1A_CHICK", "mass": 38901.0, "length": 337, "protein_name": "Casein kinase I isoform alpha", "gene_name": "CSNK1A1", "organism": "Chicken", "refseq_name": "casein kinase I isoform alpha", "refseq_ac": "NP_990384", "gene_names_uniprotkb": "CSNK1A1", "gene_names_refseq": "CSNK1A1L; CSNK1A1", "protein_names_uniprotkb": "Casein kinase I isoform alpha; 2.7.11.1; CK1; CKI-alpha", "protein_names_refseq": "CK1; CKI-alpha; casein kinase 1 alpha 1 like; casein kinase I alpha LS; casein kinase I isoform alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:395924); (R-GGA-195253); (R-GGA-196299); (R-GGA-5610785); (R-GGA-5635838); (R-GGA-69601)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "9766967", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U80823.1, ERR2286007.132083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ446617.1, BU284176.1, AF042863.1, U80822.1, AL584120.1, BI067393.1, AJ728831.1, CB016751.1, AJ728830.1, CR387289.1 and AJ728829.1., [RefSeq]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O57528;P70065;P79789;P79790", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;3.1.3.16;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.-;3.1.3.48;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0016607 nuclear speck", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0051301 cell division;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P67962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NN44-1", "uniprot_id": "F1NN44_CHICK", "mass": 56797.0, "length": 519, "protein_name": "Alkaline phosphatase", "gene_name": "ALPL", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ALPL", "gene_names_refseq": "", "protein_names_uniprotkb": "Alkaline phosphatase; 3.1.3.1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396317); (R-GGA-163125)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;3.6.1.1;5.6.1.6;2.4.2.31;5.6.2.4;3.1.3.2;3.6.4.10;3.6.4.12;5.6.2.3;3.6.1.6;3.1.4.1;3.6.1.9;3.1.4.50;2.7.4.3;3.2.2.6;4.2.99.18;2.7.11.1;7.2.2.-;3.4.11.9;3.1.3.1;3.6.5.-;3.6.4.-;3.1.3.75;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.74;3.1.3.16;3.6.1.15;3.6.1.-;3.1.3.48", "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0033883 pyridoxal phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0004035 alkaline phosphatase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:1904383 response to sodium phosphate;GO:0055062 phosphate ion homeostasis;GO:0055074 calcium ion homeostasis;GO:0033280 response to vitamin D;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NN44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NPG5-1", "uniprot_id": "CENPT_CHICK", "mass": 70670.0, "length": 639, "protein_name": "Centromere protein T", "gene_name": "CENPT", "organism": "Chicken", "refseq_name": "centromere protein T", "refseq_ac": "NP_001263242", "gene_names_uniprotkb": "CENPT", "gene_names_refseq": "CENP-T; CENPT", "protein_names_uniprotkb": "Centromere protein T; CENP-T", "protein_names_refseq": "centromere protein T", "tax_id": 9031, "disease": "", "pathway": " (gga:415654)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12445392;15592404;19070575;21464230;22304917;23334297;26791246;35165266", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.301599.1, SRR13267649.91413.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000247.1. On Sep 23, 2021 this sequence version replaced NP_001263242.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; As the cell cycle is mostly formed from G1, S and G2 phases a gradual loss of CENP-T/W levels is more likely to reflect dependencies associated with kinetochore assembly pre-mitosis and upon entry into mitosis., [RefSeq, PubMed]; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis., [UniProtKB, PubMed, PubMed]; Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F1NPG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NPU8-1", "uniprot_id": "F1NPU8_CHICK", "mass": 23802.0, "length": 207, "protein_name": "High mobility group protein B2", "gene_name": "HMGB2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HMGB2", "gene_names_refseq": "", "protein_names_uniprotkb": "High mobility group protein B2; High mobility group protein 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396482); (R-GGA-140342)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0050786 RAGE receptor binding;GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0042056 chemoattractant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NPU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NQJ3-1", "uniprot_id": "PMS2_CHICK", "mass": 97996.0, "length": 869, "protein_name": "Mismatch repair endonuclease PMS2", "gene_name": "PMS2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PMS2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mismatch repair endonuclease PMS2; 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:101752182); (R-GGA-5358565)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15592404;15642098;23314153", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZJ94", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;3.1.-.-;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004519 endonuclease activity;GO:0003697 single-stranded DNA binding;GO:0032138 single base insertion or deletion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0032389 MutLalpha complex", "go_biological_process": "GO:0000710 meiotic mismatch repair;GO:0030890 positive regulation of B cell proliferation;GO:0006298 mismatch repair;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0048304 positive regulation of isotype switching to IgG isotypes", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1NQJ3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NSM7-1", "uniprot_id": "OC116_CHICK", "mass": 76870.0, "length": 743, "protein_name": "Ovocleidin-116", "gene_name": "", "organism": "Chicken", "refseq_name": "ovocleidin-116 precursor", "refseq_ac": "NP_989900", "gene_names_uniprotkb": "", "gene_names_refseq": "MEPE; OC-116", "protein_names_uniprotkb": "Ovocleidin-116; OC-116", "protein_names_refseq": "ovocleidin-116 precursor; ovocleidin-116 protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395256)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10551857;12225802;15535969;15592404;18648057;20665709;28844534", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF148716.3, BM439558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF148716.3., [RefSeq]; Major component of the eggshell matrix. May play an important role in the regulation of calcite growth during eggshell calcification. May also regulate the mineralization process in developing and growing bones., [UniProtKB, PubMed, PubMed, PubMed]; OC-116 is involved early in chicken ontogeny and as soon as osteogenesis begins, [RefSeq, PubMed]; This is the first report demonstrating the presence in SSTs of the OC-116, OC-17 and OCX36 eggshell matrix proteins, and their concomitant presence with Gal/GalNAc and Glc/GlcNAc glycans, as well as with calcium. The results suggest that the OC-116, OC-17 and OCX36 eggshell matrix proteins may be involved in sperm storage., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9PUT1", "ec_number_list": "", "go_molecular_function": "GO:1990430 extracellular matrix protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0031012 extracellular matrix", "go_biological_process": "GO:0031214 biomineral tissue development;GO:0031215 shell calcification", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "F1NSM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NUK7-1", "uniprot_id": "FLRT3_CHICK", "mass": 73292.0, "length": 647, "protein_name": "Leucine-rich repeat transmembrane protein FLRT3", "gene_name": "FLRT3", "organism": "Chicken", "refseq_name": "leucine-rich repeat transmembrane protein FLRT3 precursor", "refseq_ac": "NP_001383374", "gene_names_uniprotkb": "FLRT3", "gene_names_refseq": "FLRT3", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane protein FLRT3; Fibronectin-like domain-containing leucine-rich transmembrane protein 3", "protein_names_refseq": "fibronectin-like domain-containing leucine-rich transmembrane protein 3; leucine-rich repeat transmembrane protein FLRT3 precursor; leucine-rich repeat transmembrane protein FLRT3", "tax_id": 9031, "disease": "", "pathway": " (gga:428552); (R-GGA-5654687)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15592404;17051480;21575622", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: CR387190.1, BU396161.1 [ECO:0000331] RNAseq introns :: partial sample support SAMN02738220 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000060.1, AL586439.1, BU396161.1 and BX934700.2., [RefSeq]; FLRT3 may have a crucial role in regulating cellular adhesion between the epithelial apical ridge and the underlying mesenchyme and in establishing the dorso-ventral position of the ridge, [RefSeq, PubMed]; Flrt3 is a key player during chicken limb development, being necessary but not sufficient for proper apical ectodermal ridge formation and maintenance under the control of BMP and WNT signalling., [RefSeq, PubMed]; Modulates the structure and function of the apical ectodermal ridge (AER) that controls embryonic limb development (PubMed:21575622). Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development. Plays a role in cell-cell adhesion via its interaction with latrophilins that are expressed at the surface of adjacent cells. Mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC-5 family members. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0045499 chemorepellent activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0032584 growth cone membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007507 heart development;GO:0031175 neuron projection development;GO:0098609 cell-cell adhesion;GO:0007416 synapse assembly;GO:0048598 embryonic morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1NUK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NUX4-1", "uniprot_id": "F1NUX4_CHICK", "mass": 286722.0, "length": 2521, "protein_name": "Serine/threonine-protein kinase TOR", "gene_name": "MTOR", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase mTOR", "refseq_ac": "XP_417614", "gene_names_uniprotkb": "MTOR", "gene_names_refseq": "MTOR", "protein_names_uniprotkb": "Serine/threonine-protein kinase TOR; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase mTOR", "tax_id": 9031, "disease": "", "pathway": " (gga:419455); (R-GGA-1257604); (R-GGA-1632852); (R-GGA-165159); (R-GGA-166208); (R-GGA-3371571); (R-GGA-380972); (R-GGA-389357); (R-GGA-5218920); (R-GGA-5628897); (R-GGA-6804757); (R-GGA-8943724); (R-GGA-9639288); (R-GGA-9856530)", "pathway_count": 14, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052552.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_417614.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.10.2;2.3.2.27;2.7.10.1;2.7.11.22;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;5.2.1.8;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;3.1.2.2;2.7.1.153;2.7.1.137;2.7.1.154;7.1.2.2;2.7.10.4;2.7.11.11", "go_molecular_function": "GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1904059 regulation of locomotor rhythm;GO:0055006 cardiac cell development;GO:0002296 T-helper 1 cell lineage commitment;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NUX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NV61-1", "uniprot_id": "CASP7_CHICK", "mass": 34722.0, "length": 309, "protein_name": "Caspase-7", "gene_name": "CASP7", "organism": "Chicken", "refseq_name": "caspase-7 isoform X2", "refseq_ac": "XP_421764", "gene_names_uniprotkb": "CASP7", "gene_names_refseq": "CASP7", "protein_names_uniprotkb": "Caspase-7; 3.4.22.60; CASP-7", "protein_names_refseq": "caspase-7 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:423901)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14583630;15592404", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052537.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_421764.2. COMPLETENESS: full length., [RefSeq]; Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins (PubMed:14583630). Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences (By similarity). Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8 and/or CASP9), mediates execution of apoptosis by catalyzing cleavage of proteins (PubMed:14583630). Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins (By similarity). Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair (By similarity). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0097194 execution phase of apoptosis;GO:0042742 defense response to bacterium;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1NV61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NW21-1", "uniprot_id": "F1NW21_CHICK", "mass": 150112.0, "length": 1348, "protein_name": "Vascular endothelial growth factor receptor 2", "gene_name": "KDR", "organism": "Chicken", "refseq_name": "vascular endothelial growth factor receptor 2 precursor", "refseq_ac": "NP_001004368", "gene_names_uniprotkb": "KDR", "gene_names_refseq": "FLK1; KDR; VEGFR2", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 2; 2.7.10.1", "protein_names_refseq": "flk-1 receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase; vascular endothelial growth factor receptor 2 precursor; vascular endothelial growth factor receptor 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395323); (R-GGA-194306); (R-GGA-195399); (R-GGA-4420097); (R-GGA-5218921)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "22991551;25698653;26367766;30602288", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY382882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1. On Sep 23, 2021 this sequence version replaced NP_001004368.1., [RefSeq]; The VEGF and VEGFR-2 genes play critical roles in feather maturity. In addition, VEGFR-2 exon10-A69G and genotype EF in the Princess chicken could potentially be utilised as genetic markers to improve efficiency in breeding., [RefSeq, PubMed]; The impact of embryonic hypoxia on hypoxia inducible factor 2alpha(HIF-2alpha), VEGF, and its type 2 receptor in 6- and 7-day-old chick embryos are reprorted., [RefSeq, PubMed]; VEGF-A and VEGF-R2 mRNA was decreased in cadmium treated extraembryonic membranes., [RefSeq, PubMed]; Vascular endothelial growth factor receptor 2 (VEGFR2) interacted with peptide Lv., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.11.24;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.39;2.7.11.23;3.6.5.2;3.1.4.11;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005178 integrin binding;GO:0005524 ATP binding;GO:0015026 coreceptor activity;GO:0019838 growth factor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0060562 epithelial tube morphogenesis;GO:0035162 embryonic hemopoiesis;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1NW21-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NWC2-1", "uniprot_id": "F1NWC2_CHICK", "mass": 40922.0, "length": 357, "protein_name": "G-protein coupled estrogen receptor 1", "gene_name": "GPER1", "organism": "Chicken", "refseq_name": "G-protein coupled estrogen receptor 1 isoform X1", "refseq_ac": "XP_004945187", "gene_names_uniprotkb": "GPER1", "gene_names_refseq": "GPCR30; GPER1; GPER; GPR30", "protein_names_uniprotkb": "G-protein coupled estrogen receptor 1; G protein-coupled estrogen receptor 1; G-protein coupled receptor 30", "protein_names_refseq": "G-protein coupled estrogen receptor 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-375276); (R-GGA-418594); (R-GGA-9634597)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052545.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_004945187.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004930 G protein-coupled receptor activity;GO:1990239 steroid hormone binding;GO:0030284 nuclear estrogen receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005769 early endosome", "go_biological_process": "GO:0002695 negative regulation of leukocyte activation;GO:0010948 negative regulation of cell cycle process;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:2000724 positive regulation of cardiac vascular smooth muscle cell differentiation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NWC2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NX79-1", "uniprot_id": "F1NX79_CHICK", "mass": 44831.0, "length": 406, "protein_name": "LIM/homeobox protein Lhx1", "gene_name": "LHX1", "organism": "Chicken", "refseq_name": "LIM/homeobox protein Lhx1", "refseq_ac": "NP_001384288", "gene_names_uniprotkb": "LHX1", "gene_names_refseq": "LHX1; LIM-1; LIM-homeobox; LIM1", "protein_names_uniprotkb": "LIM/homeobox protein Lhx1; Homeobox protein Lim-1", "protein_names_refseq": "LIM homeobox protein 1; LIM/homeobox protein Lhx1; domesticus (clone 2.3 kB) lim-1; homeobox protein Lim-1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "18033670;24024588;24247150", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267662.26010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On Nov 9, 2021 this sequence version replaced XP_015151168.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DNA damage response pathway is functional in the Lim1 horizontal progenitor cells, but that it is not directly involved in the regulation of the final cell cycle that gives rise to the heteroploid horizontal cell population., [RefSeq, PubMed]; Expression dynamics of LHX1 in the diencephalon during chick development is reported., [RefSeq, PubMed]; Results suggest that Lhx1 and Lhx5 in the forebrain regulate neural retina differentiation by suppressing the development of the retinal pigment epithelium, before the formation of the optic vesicle (OV)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1NX79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1NXR1-1", "uniprot_id": "F1NXR1_CHICK", "mass": 17516.0, "length": 151, "protein_name": "Caveolin", "gene_name": "CAV3", "organism": "Chicken", "refseq_name": "caveolin-3", "refseq_ac": "NP_989701", "gene_names_uniprotkb": "CAV3", "gene_names_refseq": "CAV3; caveolin-3", "protein_names_uniprotkb": "Caveolin", "protein_names_refseq": "caveolin-3", "tax_id": 9031, "disease": "", "pathway": " (gga:378796)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20451648", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX931541.1, BX934028.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000252.1. On Jul 8, 2015 this sequence version replaced NP_989701.1., [RefSeq]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae., [UniProtKB, UniProtKB]; The results suggest that the accumulation of caveolin-3 protein may be associated with the causative process of chicken muscular dystrophy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0071253 connexin binding;GO:0060090 molecular adaptor activity;GO:0005246 calcium channel regulator activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005901 caveola;GO:0042383 sarcolemma", "go_biological_process": "GO:0035995 detection of muscle stretch;GO:0060299 negative regulation of sarcomere organization;GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0090279 regulation of calcium ion import;GO:1900826 negative regulation of membrane depolarization during cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1NXR1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1P3B6-1", "uniprot_id": "F1P3B6_CHICK", "mass": 94197.0, "length": 828, "protein_name": "Prickle planar cell polarity protein 1", "gene_name": "PRICKLE1", "organism": "Chicken", "refseq_name": "prickle-like protein 1", "refseq_ac": "XP_015137914", "gene_names_uniprotkb": "PRICKLE1", "gene_names_refseq": "PRICKLE1", "protein_names_uniprotkb": "Prickle planar cell polarity protein 1", "protein_names_refseq": "prickle-like protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:417793); (R-GGA-4608870)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0031965 nuclear membrane;GO:0000502 proteasome complex", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0061326 renal tubule development;GO:0007409 axonogenesis;GO:0016358 dendrite development;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P3B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1P3H0-1", "uniprot_id": "F1P3H0_CHICK", "mass": 60269.0, "length": 533, "protein_name": "receptor protein serine/threonine kinase", "gene_name": "BMPR1A", "organism": "Chicken", "refseq_name": "bone morphogenetic protein receptor type-1A precursor", "refseq_ac": "NP_990688", "gene_names_uniprotkb": "BMPR1A", "gene_names_refseq": "ALK-3; BMPR-1; BMPR1A; BRK-1", "protein_names_uniprotkb": "receptor protein serine/threonine kinase; 2.7.11.30", "protein_names_refseq": "BMP receptor 1; bone morphogenetic protein receptor type-1A precursor; bone morphogenetic protein receptor, type IA; bone morphogenic protein receptor 1; protein kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:396308); (R-GGA-201451)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15804571;27048361;28359351", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L49204.1, SRR13267652.137.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000227.1. On Sep 23, 2021 this sequence version replaced NP_990688.1., [RefSeq]; BMP signaling via Bmpr1a and Bmpr1b, is sufficient to modify nuclear organization in the chick diencephalon, [RefSeq, PubMed]; The finding that retinal gene expression for BMP2, 4, 7 and their receptors are not affected by short-term optical defocus contrasts with previous observations of sign-dependent expression changes for the same genes in the RPE., [RefSeq, PubMed]; This paper highlights that targeting the BMP and TGFbeta type I and type II receptors causes a downregulation of XIAP, TAK1, and Id1 leading to cell death of lung cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.26;2.7.11.30", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005025 transforming growth factor beta receptor activity, type I;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0005901 caveola", "go_biological_process": "GO:0001525 angiogenesis;GO:0006955 immune response;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1P3H0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1P3Y2-1", "uniprot_id": "F1P3Y2_CHICK", "mass": 39299.0, "length": 351, "protein_name": "Rhodopsin", "gene_name": "RHO", "organism": "Chicken", "refseq_name": "rhodopsin", "refseq_ac": "NP_001384426", "gene_names_uniprotkb": "RHO", "gene_names_refseq": "CSNBAD1; OPN2; RDP1; RHO; RP4; opsin-2", "protein_names_uniprotkb": "Rhodopsin", "protein_names_refseq": "opsin 2, rod pigment; rhodopsin", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2453902); (R-GGA-2485179); (R-GGA-2514859); (R-GGA-418594); (R-GGA-419771); (R-GGA-5620916)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "25244004", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DR424575.1, HAEK01085415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000252.1, DR428276.1, HAEK01113968.1, BG712512.1, DR427770.1 and DR426148.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Rhodopsin gene transcription was dependent on calcium signaling and HCN1 channels in retinal precursor cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0060342 photoreceptor inner segment membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0097381 photoreceptor disc membrane", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1P3Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "F1P5L0-1", "uniprot_id": "F1P5L0_CHICK", "mass": 65793.0, "length": 607, "protein_name": "Sodium-coupled monocarboxylate transporter 1", "gene_name": "SLC5A8", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC5A8", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; Solute carrier family 5 member 8", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:417932); (R-GGA-196807); (R-GGA-428643); (R-GGA-9958790)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6", "go_molecular_function": "GO:0090416 nicotinate transmembrane transporter activity;GO:0005343 organic acid:sodium symporter activity;GO:0015129 lactate transmembrane transporter activity;GO:0015552 propionate transmembrane transporter activity;GO:0140161 monocarboxylate:sodium symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0000811 GINS complex", "go_biological_process": "GO:0006821 chloride transport;GO:0015705 iodide transport;GO:0006814 sodium ion transport;GO:0006848 pyruvate transport;GO:0015706 nitrate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P5L0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "I0IUP3-1", "uniprot_id": "MCM8_CHICK", "mass": 92809.0, "length": 830, "protein_name": "DNA helicase MCM8", "gene_name": "MCM8", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MCM8; RCJMB04_5o15", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA helicase MCM8; 5.6.2.4; DNA 3'-5' helicase MCM8; Minichromosome maintenance 8", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421314); (R-GGA-176187); (R-GGA-68689); (R-GGA-68949); (R-GGA-68962)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15592404;15642098;22771115;37535404", "class_list": "", "function": "Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and which plays a key role during gametogenesis (PubMed:22771115). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (By similarity). It probably processes aberrant forks into homologous recombination substrates and orchestrates homologous recombination with resection, fork stabilization and fork restart (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1BWN1;F1NEZ3;Q5F3V9", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;2.7.7.7;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.11.22;2.7.7.49;2.7.7.-;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0097362 MCM8-MCM9 complex;GO:0042555 MCM complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "I0IUP3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "I0IUP4-1", "uniprot_id": "MCM9_CHICK", "mass": 129682.0, "length": 1169, "protein_name": "DNA helicase MCM9", "gene_name": "MCM9", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MCM9", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA helicase MCM9; 5.6.2.4; DNA 3'-5' helicase MCM9; Minichromosome maintenance 9", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:100857742)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15592404;22771115;37535404", "class_list": "", "function": "Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and which plays a key role during gametogenesis (PubMed:22771115). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (By similarity). It probably processes aberrant forks into homologous recombination substrates and orchestrates homologous recombination with resection, fork stabilization and fork restart (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1N960", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0097362 MCM8-MCM9 complex;GO:0042555 MCM complex", "go_biological_process": "GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "I0IUP4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O12971-1", "uniprot_id": "LFNG_CHICK", "mass": 40658.0, "length": 363, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "gene_name": "LFNG", "organism": "Chicken", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "refseq_ac": "NP_990279", "gene_names_uniprotkb": "LFNG", "gene_names_refseq": "LFNG", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; lunatic fringe homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:395790)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "9121552;9175788", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U91849.1, U97157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1., [RefSeq]; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O13130", "ec_number_list": "2.4.1.222", "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007389 pattern specification process;GO:0014807 regulation of somitogenesis;GO:0030217 T cell differentiation;GO:1902367 negative regulation of Notch signaling pathway involved in somitogenesis;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O12971-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13016-1", "uniprot_id": "PTN1_CHICK", "mass": 50334.0, "length": 434, "protein_name": "Tyrosine-protein phosphatase non-receptor type 1", "gene_name": "PTPN1", "organism": "Chicken", "refseq_name": "tyrosine-protein phosphatase non-receptor type 1", "refseq_ac": "NP_990206", "gene_names_uniprotkb": "PTPN1; PTP1B", "gene_names_refseq": "CPTP1; PTP-1B; PTP1B; PTPN1", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 1; 3.1.3.48; CPTP1; PTP-1B; Protein-tyrosine phosphatase 1B", "protein_names_refseq": "non-receptor protein tyrosine phosphatase; phosphoprotein phosphatase; protein-tyrosine phosphatase 1B; tyrosine-protein phosphatase non-receptor type 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395688)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19158394;8707857;9600099", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U86410.1, SRR13267655.161780.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000328.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Growth cone contact with cellular targets is accompanied by invasion of PTP1B and stable microtubules in the peripheral region aligned with the contact axis, [RefSeq, PubMed]; May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90704", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.67;3.1.3.21;3.1.3.18;3.1.3.2", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0030100 regulation of endocytosis;GO:0030036 actin cytoskeleton organization;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O13016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13076-1", "uniprot_id": "AA2BR_CHICK", "mass": 37772.0, "length": 340, "protein_name": "Adenosine receptor A2b", "gene_name": "ADORA2B", "organism": "Chicken", "refseq_name": "adenosine receptor A2b", "refseq_ac": "NP_990418", "gene_names_uniprotkb": "ADORA2B", "gene_names_refseq": "A2B-AR; ADORA2B", "protein_names_uniprotkb": "Adenosine receptor A2b; Adenosine receptor 2b", "protein_names_refseq": "adenosine receptor 2b; adenosine receptor A2b", "tax_id": 9031, "disease": "", "pathway": " (gga:395971); (R-GGA-417973); (R-GGA-418555); (R-GGA-5683826)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12559577;17822556;23956030;9244356", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y12601.1, HAEK01096852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Y12601.1 and JAENSK010000323.1. On Aug 30, 2004 this sequence version replaced XP_429277.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Maternal leukocyte ADORA2B overexpression is associated with hyperglycemia in gestational diabetes mellitus subjects., [RefSeq, PubMed]; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase., [UniProtKB]; The promoter region of the chicken adenosine receptor 2B gene (Adora2B), a known Myb-target gene, acts as a DNA replication origin Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q540H7", "ec_number_list": "", "go_molecular_function": "GO:0001609 G protein-coupled adenosine receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042311 vasodilation;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O13076-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O13154-1", "uniprot_id": "PACN2_CHICK", "mass": 51971.0, "length": 448, "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 2", "gene_name": "PACSIN2", "organism": "Chicken", "refseq_name": "protein kinase C and casein kinase substrate in neurons protein 2 isoform 1", "refseq_ac": "NP_001152983", "gene_names_uniprotkb": "PACSIN2", "gene_names_refseq": "FAP52; PACSIN2; p52", "protein_names_uniprotkb": "Protein kinase C and casein kinase substrate in neurons protein 2; FAP52; Focal adhesion protein of 52 kDa", "protein_names_refseq": "focal adhesion protein of 52 kDa; protein kinase C and casein kinase substrate in neurons protein 2 isoform 1; protein kinase C and casein kinase substrate in neurons protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395975)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9287337", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.4298.1, SRR13267661.29105.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Sep 23, 2021 this sequence version replaced NP_001152983.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1)., [RefSeq]; Regulates the morphogenesis and endocytosis of caveolae. Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008092 cytoskeletal protein binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0006897 endocytosis;GO:0030100 regulation of endocytosis;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O13154-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42130-1", "uniprot_id": "TOP2A_CHICK", "mass": 174993.0, "length": 1553, "protein_name": "DNA topoisomerase 2-alpha", "gene_name": "TOP2A", "organism": "Chicken", "refseq_name": "DNA topoisomerase 2-alpha", "refseq_ac": "NP_990122", "gene_names_uniprotkb": "TOP2A", "gene_names_refseq": "TOP2A", "protein_names_uniprotkb": "DNA topoisomerase 2-alpha; 5.6.2.2; DNA topoisomerase II, alpha isozyme", "protein_names_refseq": "DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; DNA topoisomeraseII_alpha; topoisomerase (DNA) II alpha 170kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:395570)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11453553;23166350;26643143;27814490;2985625", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.988.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000365.1. On Dec 3, 2021 this sequence version replaced NP_990122.2., [RefSeq]; Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 nuclease activity is likely to remove the DNA lesions. Erratum:[Mol Cell. 2016 Dec 1;64(5):1010. doi: 10.1016/j.molcel.2016.11.028. PMID: 27912094], [RefSeq, PubMed]; Found in chicken chromosome scaffolds. Chicken topoisomerase II is located in the neucleus, associated with mitotic chromosomes and chromosome scaffolds., [RefSeq, PubMed]; Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in the regulation of circadian rhythm (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis. Publication Status: Online-Only, [RefSeq, PubMed]; The topoisomerase IIalpha contributed to shaping mitotic chromosomes by promoting the shortening of the chromatid axes and apparently acting in opposition to the actions of KIF4 and condensins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0007059 chromosome segregation;GO:0043065 positive regulation of apoptotic process;GO:0051301 cell division;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O42130-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42131-1", "uniprot_id": "TOP2B_CHICK", "mass": 183246.0, "length": 1627, "protein_name": "DNA topoisomerase 2-beta", "gene_name": "TOP2B", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TOP2B", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA topoisomerase 2-beta; 5.6.2.2; DNA topoisomerase II, beta isozyme", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395966)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11453553", "class_list": "", "function": "Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003916 DNA topoisomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0030183 B cell differentiation;GO:0006265 DNA topological change;GO:0000819 sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O42131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42164-1", "uniprot_id": "LEP_CHICK", "mass": 18183.0, "length": 163, "protein_name": "Leptin", "gene_name": "LEP", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LEP; OB", "gene_names_refseq": "", "protein_names_uniprotkb": "Leptin; Obesity factor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9524275", "class_list": "", "function": "Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:1990460 leptin receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:2000866 positive regulation of estradiol secretion;GO:0006629 lipid metabolic process;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O42164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42220-1", "uniprot_id": "GDF8_CHICK", "mass": 42707.0, "length": 375, "protein_name": "Growth/differentiation factor 8", "gene_name": "MSTN", "organism": "Chicken", "refseq_name": "growth/differentiation factor 8 precursor", "refseq_ac": "NP_001001461", "gene_names_uniprotkb": "MSTN; GDF8", "gene_names_refseq": "GDF-8; GDF8; MSTN", "protein_names_uniprotkb": "Growth/differentiation factor 8; GDF-8; Myostatin", "protein_names_refseq": "growth/differentiation factor 8 precursor; growth/differentiation factor 8", "tax_id": 9031, "disease": "", "pathway": " (gga:373964)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14757186;15382673;15566475;16180589;30325085;31127166;35141787;9356471", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GU075927.1, AY448007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000235.1. On Aug 30, 2004 this sequence version replaced XP_421839.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts specifically as a negative regulator of skeletal muscle growth., [UniProtKB]; Beneficial impact of dietary methyl methionine sulfonium chloride and/or L-carnitine supplementation on growth performance, feed efficiency, and serum biochemical parameters in broiler chicken: role of IGF-1 and MSTN genes. Publication Status: Online-Only, [RefSeq, PubMed]; Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Publication Status: Online-Only, [RefSeq, PubMed]; MSTN regulates myogenesis by promoting EMT during somitogenesis., [RefSeq, PubMed]; Myostatin (MSTN) is sensitive to nutrient supply in hatching chicks, and fasting reduced MSTN mRNA levels in muscles of older chickens., [RefSeq, PubMed]; Myostatin was expressed in the ventral myotomal region of mature somites, confirming the importance of myostatin in skeletal muscle tissue formation during embryogenesis, [RefSeq, PubMed]; Single nucleotide polymorphisms of the myostatin gene play an important role in controlling skeletal muscle growth and differentiation, and also may be involved in regulation of adipose growth, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q53YW8;Q98SP0", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0014816 skeletal muscle satellite cell differentiation;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0009792 embryo development ending in birth or egg hatching;GO:0040008 regulation of growth;GO:0046716 muscle cell cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O42220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42254-1", "uniprot_id": "IF2B1_CHICK", "mass": 63271.0, "length": 576, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 1", "gene_name": "IGF2BP1", "organism": "Chicken", "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 1", "refseq_ac": "NP_990402", "gene_names_uniprotkb": "IGF2BP1; VICKZ1; ZBP1", "gene_names_refseq": "IGF2BP1; ZBP1", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; VICKZ family member 1; ZBP-1; Zip-code binding polypeptide; Zipcode-binding protein 1", "protein_names_refseq": "IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; VICKZ family member 1; ZBP-1; insulin-like growth factor 2 mRNA-binding protein 1; zip code-binding protein 1; zip-code binding polypeptide; zipcode-binding protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395953)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11502257;12507992;12573215;16306994;17101699;22279049;23069990;23640942;36069737;37377445;9121465", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF026527.1, SRR13267649.152444.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000364.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Chicken ZBP1 modulates the translation of beta-actin mRNA, [RefSeq, PubMed]; Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers., [RefSeq, PubMed]; METTL21C mediates lysine trimethylation of IGF2BP1 to regulate chicken myoblast proliferation., [RefSeq, PubMed]; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation in polarized cells, a crucial process for cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves by a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The ribonucleoparticle (RNP) thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, IGF2BP1 prevents beta-actin mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated by SRC. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. The monomeric ACTB protein then assembles into the subcortical actin cytoskeleton, which pushes the leading edge onwards. Binds MYC mRNA. Binding to MYC mRNA is enhanced by m6A-modification of the CRD (By similarity). Promotes the directed movement of cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Zipcode-binding protein 1 (ZBP1) regulates the cytoplasmic fate of specific mRNAs in nonstressed cells and is a key regulator of mRNA turnover during the integrated stress response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030426 growth cone", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0017148 negative regulation of translation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O42254-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42392-1", "uniprot_id": "VDR_CHICK", "mass": 51300.0, "length": 451, "protein_name": "Vitamin D3 receptor", "gene_name": "VDR", "organism": "Chicken", "refseq_name": "vitamin D3 receptor", "refseq_ac": "NP_990429", "gene_names_uniprotkb": "VDR; NR1I1", "gene_names_refseq": "VDR", "protein_names_uniprotkb": "Vitamin D3 receptor; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1; VDR", "protein_names_refseq": "1,25-dihydroxyvitamin D3 receptor; nuclear receptor subfamily 1 group I member 1; vitamin D receptor; vitamin D3 receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:395988)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15203106;16734694;17156784;18492999;25185950;3029866;9056239", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF011356.1, SRR13267649.127995.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000489.1. On Sep 23, 2021 this sequence version replaced NP_990429.1., [RefSeq]; Analysus of 3 uncorrelated genetic markers (single nucleotide polymorphisms) in the vitamin D receptor gene for association with Marek's disease resistance., [RefSeq, PubMed]; Differential VDR expression in the epididymal region segments reveals that several extratesticular ducts may be targets for vitamin D3 action; vitamin D3 may have a regional-specific function, such as calcium transport., [RefSeq, PubMed]; Endogenous TRPC3-like proteins and the VDR participate in the modulation of CCE by 1alpha,25(OH)2D3 in muscle cells, which could be mediated by an interaction between these proteins, [RefSeq, PubMed]; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Polymorphisms within the VDR gene are associated with bone mineral content of the humerus at 35 weeks of age., [RefSeq, PubMed]; The knockdown of chicken PIWIL1 and PIWIL2 decreased the expression of piRNA-linked gene VDR in the primordial germ cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0005499 vitamin D binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005901 caveola", "go_biological_process": "GO:0070561 vitamin D receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O42392-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42406-1", "uniprot_id": "SIX3_CHICK", "mass": 34677.0, "length": 314, "protein_name": "Homeobox protein SIX3", "gene_name": "SIX3", "organism": "Chicken", "refseq_name": "homeobox protein SIX3", "refseq_ac": "NP_989695", "gene_names_uniprotkb": "SIX3", "gene_names_refseq": "CSIX3; SIX3", "protein_names_uniprotkb": "Homeobox protein SIX3; CSIX3; Sine oculis homeobox homolog 3", "protein_names_refseq": "homeobox protein SIX3; sine oculis homeobox homolog 3", "tax_id": 9031, "disease": "", "pathway": " (gga:378786)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12050133;12167403;12569128;9510037", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AADN05000005.1. On Jan 17, 2016 this sequence version replaced XP_015139313.1., [RefSeq]; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:12569128). Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 and CCND2. During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm. In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation. Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory. Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner (PubMed:12050133). Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element. Directly activates RHO transcription, or cooperates with CRX or NRL. Six3 also functions in the formation of the proximodistal axis of the optic cup, and promotes the formation of optic vesicles-like structures. During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway. Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53Z11", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0014016 neuroblast differentiation;GO:1990086 lens fiber cell apoptotic process;GO:0061074 regulation of neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O42406-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42410-1", "uniprot_id": "IKZF1_CHICK", "mass": 57586.0, "length": 518, "protein_name": "DNA-binding protein Ikaros", "gene_name": "IKZF1", "organism": "Chicken", "refseq_name": "DNA-binding protein Ikaros isoform a", "refseq_ac": "NP_990419", "gene_names_uniprotkb": "IKZF1; IKAROS; IK; ZNFN1A1", "gene_names_refseq": "IKAROS; IKZF1; ZNFN1A1", "protein_names_uniprotkb": "DNA-binding protein Ikaros; Ikaros family zinc finger protein 1", "protein_names_refseq": "DNA-binding protein Ikaros isoform a; DNA-binding protein Ikaros; Ikaros transcription factor; ikaros family zinc finger protein 1; zinc finger protein, subfamily 1A, 1 (Ikaros)", "tax_id": 9031, "disease": "", "pathway": " (gga:395974)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20602434;9295018", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.230738.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000041.1. On or before Dec 10, 2021 this sequence version replaced XP_015137756.1, NP_990419.1., [RefSeq]; Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Involved in the regulation of BCR signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045892 negative regulation of DNA-templated transcription;GO:0016049 cell growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O42410-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42414-1", "uniprot_id": "NFASC_CHICK", "mass": 152955.0, "length": 1369, "protein_name": "Neurofascin", "gene_name": "NFASC", "organism": "Chicken", "refseq_name": "neurofascin isoform 2 precursor", "refseq_ac": "NP_001004493", "gene_names_uniprotkb": "NFASC", "gene_names_refseq": "NFASC", "protein_names_uniprotkb": "Neurofascin", "protein_names_refseq": "neurofascin isoform 2 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:419824)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1377696;16314110;19666467;9353344", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X65224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JAENSK010000356.1. This gene encodes a member of the L1 subgroup of the immunoglobulin superfamily. Members of the L1 subgroup are associated with axons during development of the nervous system, and are characterized by the presence in the extracellular portion of the protein of six immunoglobulin-like domains and five fibronectin type III-like repeats. This gene undergoes extensive alternative splicing. Additional variants have been described but are of lower abundance. [provided by RefSeq, May 2009]. Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; A neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development, [RefSeq, PubMed]; Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions., [UniProtKB]; Results describe the roles of specific neurofascin isoforms in chick embryo dorsal root ganglion cells., [RefSeq, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 16, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q90924", "ec_number_list": "", "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O42414-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O42422-1", "uniprot_id": "EPHA7_CHICK", "mass": 111367.0, "length": 993, "protein_name": "Ephrin type-A receptor 7", "gene_name": "EPHA7", "organism": "Chicken", "refseq_name": "ephrin type-A receptor 7 isoform 1 precursor", "refseq_ac": "NP_990414", "gene_names_uniprotkb": "EPHA7; CEK11", "gene_names_refseq": "CEPHA7; EPHA7", "protein_names_uniprotkb": "Ephrin type-A receptor 7; 2.7.10.1; EK11; EPH-like kinase 11; Tyrosine-protein kinase receptor CEPHA7; cEK11", "protein_names_refseq": "EK11; EPH-like kinase 11; Eph-like receptor tyrosine kinase; cEK11; ephrin type-A receptor 7 isoform 1 precursor; ephrin type-A receptor 7; tyrosine-protein kinase receptor CEPHA7", "tax_id": 9031, "disease": "", "pathway": " (gga:395967)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16844303;9431814", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y14271.1, SRR13267649.18724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000065.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; EphA7 receptor is expressed differentially at chicken prosomeric boundaries., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0006915 apoptotic process;GO:0022407 regulation of cell-cell adhesion;GO:0007420 brain development;GO:0031952 regulation of protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O42422-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O57579-1", "uniprot_id": "AMPN_CHICK", "mass": 109132.0, "length": 972, "protein_name": "Aminopeptidase Ey", "gene_name": "ANPEP", "organism": "Chicken", "refseq_name": "aminopeptidase Ey", "refseq_ac": "NP_990192", "gene_names_uniprotkb": "ANPEP; APDE", "gene_names_refseq": "ANPEP; APDE; CD13; p150", "protein_names_uniprotkb": "Aminopeptidase Ey; 3.4.11.20; Aminopeptidase N", "protein_names_refseq": "alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150); aminopeptidase Ey", "tax_id": 9031, "disease": "", "pathway": " (gga:395667)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15592404;7684960;8205380;8288037;9734335", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: GU223212.1, JX014437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000246.1. On Sep 23, 2021 this sequence version replaced NP_990192.1., [RefSeq]; Broad specificity aminopeptidase. Degrades a variety of peptides possessing various N-terminal amino acids including hydrophobic, basic and acidic amino acids. Preferentially hydrolyzes small peptides consisting of 4 or 5 amino acids. Hydrolyzes the N-terminal Xaa-Pro bonds in the chicken brain peptide Leu-Pro-Leu-Arg-PheNH2, the substance P fragment Arg-Pro-Lys-Pro and the bradykinin fragment Arg-Pro-Pro-Gly-Phe. Hydrolyzes the N-formylated peptides fMet-Leu-Phe, fMet-Ala-Gly-Ser-Glu and fMet-Nle-Leu-Phe-Nle-Tyr-Lys, but does not hydrolyze peptides with acetylation or pyroglutamic acid at N-terminus. Does not hydrolyze large peptides such as complete substance P, bradykinin or schistoFLRFamide., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5NWZ2;D2KKL5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0002003 angiotensin maturation;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O57579-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O57598-1", "uniprot_id": "ATOH7_CHICK", "mass": 17540.0, "length": 151, "protein_name": "Transcription factor ATOH7", "gene_name": "ATOH7", "organism": "Chicken", "refseq_name": "transcription factor ATOH7", "refseq_ac": "NP_989999", "gene_names_uniprotkb": "ATOH7; ATH5", "gene_names_refseq": "ATH5; ATOH7", "protein_names_uniprotkb": "Transcription factor ATOH7; Atonal bHLH transcription factor 7; Helix-loop-helix protein cATH-5; Protein atonal homolog 5; Protein atonal homolog 7; cATH5", "protein_names_refseq": "Atonal Homolog 5; atonal transcription factor homologue; cATH5; helix-loop-helix protein cATH-5; protein atonal homolog 5; protein atonal homolog 7; transcription factor ATOH7", "tax_id": 9031, "disease": "", "pathway": " (gga:395388)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11124117;11172005;15306648;15342472;16079155;16260616;19855019", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AJ001178.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ001178.1., [RefSeq]; ATH5 is selected by the beta3 promoter and coordinates the derepression and transcriptional activation of the beta3 gene during the specification of retinal ganglion cells, [RefSeq, PubMed]; Ath5 may lead to the photoreceptor pathway by inducing neuroD; takes part in retinal ganglion cell differentiation, [RefSeq, PubMed]; In the mouse and chick retina, species-related variations in the chromatin-binding profiles of bHLH transcription factors correlate with distinct features of the Atoh7 promoters and underlie variations in the transcriptional rates of the Atoh7 genes., [RefSeq, PubMed]; Inactivation of the ATH5 promoter in differentiated neurons is accompanied by replication-independent chromatin de-methylation, [RefSeq, PubMed]; Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Positively regulates the determination of retinal ganglion cell fate and formation of the optic nerve and retino-hypothalamic tract (PubMed:11124117, PubMed:15342472, PubMed:16260616). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3 (PubMed:11172005)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030424 axon;GO:0043204 perikaryon", "go_biological_process": "GO:0003407 neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010996 response to auditory stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O57598-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O57604-1", "uniprot_id": "PODXL_CHICK", "mass": 61015.0, "length": 571, "protein_name": "Podocalyxin", "gene_name": "PODXL", "organism": "Chicken", "refseq_name": "podocalyxin precursor", "refseq_ac": "NP_001258823", "gene_names_uniprotkb": "PODXL; MEP21; PCLP1; PCLP", "gene_names_refseq": "MEP21; PCLP-1; PC; PODXL", "protein_names_uniprotkb": "Podocalyxin; PCLP-1; PC; Podocalyxin-like protein 1; Thrombomucin", "protein_names_refseq": "podocalyxin precursor; podocalyxin-like protein 1; thrombomucin", "tax_id": 9031, "disease": "", "pathway": " (gga:395755)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17311105;9298993", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y13978.1, SRR13267659.112791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000009.1. On or before Dec 12, 2012 this sequence version replaced XP_003640372.1, XP_416475.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same breed was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells (By similarity). Induces the formation of apical actin-dependent microvilli., [UniProtKB, PubMed]; Recombinant chicken podocalyxin recruits NHERF-1 to the apical domain of human MCF-7 cells and promotes microvillus formation. Podocalyxin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0072175 epithelial tube formation;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0022408 negative regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O57604-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O73707-1", "uniprot_id": "CAC1C_CHICK", "mass": 19957.0, "length": 177, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1C", "gene_name": "CACNA1C", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CACNA1C", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1C; CHCACHA1C; Voltage-gated calcium channel subunit alpha Cav1.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9405708", "class_list": "", "function": "Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (By similarity). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (By similarity). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0042383 sarcolemma;GO:0030315 T-tubule", "go_biological_process": "GO:0061337 cardiac conduction;GO:0070588 calcium ion transmembrane transport;GO:0060402 calcium ion transport into cytosol;GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O73707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O73755-1", "uniprot_id": "GREM1_CHICK", "mass": 21166.0, "length": 184, "protein_name": "Gremlin-1", "gene_name": "GREM1", "organism": "Chicken", "refseq_name": "gremlin-1 precursor", "refseq_ac": "NP_990309", "gene_names_uniprotkb": "GREM1", "gene_names_refseq": "Drm/Gremlin/drm; Drm; GREM1; gremlin", "protein_names_uniprotkb": "Gremlin-1", "protein_names_refseq": "Down-regulated by v-mos; gremlin 1 homolog, cysteine knot superfamily; gremlin 1, cysteine knot superfamily, homolog; gremlin-1 precursor; gremlin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:395826)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14991724;15256670;16989805;20565961;22884497;23764427;32251937;9660951", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267656.18046.1, SRR13267659.208190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1., [RefSeq]; Bone morphogenetic protein activity is necessary and sufficient for induction of Gremlin., [RefSeq, PubMed]; Cytokine that may play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling., [UniProtKB, PubMed]; Determination of the roles of GREM1 gene in granulosa cell proliferation and steroidogenesis of hen ovarian prehierarchical follicles., [RefSeq, PubMed]; Drm (gremlin) could play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling, [RefSeq, PubMed]; Early stages of the GREM1-SHH-FGF signaling network are resistant to Chrdl1-overexpression, with normal formation of proximal limb structures, but later Bmp expression, impaired by ectopic CHRDL1, is essential for the correct complement of digits, [RefSeq, PubMed]; Shh-expressing cells and their descendants cannot express Gremlin; proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells which breaks down the Shh-Fgf4 loop and affects limb size, [RefSeq, PubMed]; Tgfbeta signaling negatively regulates the expression of the BMP-antagonist Gremlin in the early limb bud. Publication Status: Online-Only, [RefSeq, PubMed]; Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity;GO:0043184 vascular endothelial growth factor receptor 2 binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0051893 regulation of focal adhesion assembly;GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0046851 negative regulation of bone remodeling;GO:0090291 negative regulation of osteoclast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O73755-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O73885-1", "uniprot_id": "HSP7C_CHICK", "mass": 70827.0, "length": 646, "protein_name": "Heat shock cognate 71 kDa protein", "gene_name": "HSPA8", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSPA8; HSC70", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395853)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9707581", "class_list": "", "function": "Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes (By similarity). Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (By similarity). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (By similarity). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state (By similarity). In the ATP-bound form, it has a low affinity for substrate proteins (By similarity). However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins (By similarity). HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (By similarity). Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2 (By similarity). KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded (By similarity). May play a role in regulating apoptosis during embryonic development (PubMed:9707581). May play a role in uncoating of clathrin-coated vesicles (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0007369 gastrulation;GO:0048568 embryonic organ development;GO:0042026 protein refolding;GO:0072318 clathrin coat disassembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O73885-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O93257-1", "uniprot_id": "XRCC6_CHICK", "mass": 72289.0, "length": 632, "protein_name": "DNA repair protein Ku70", "gene_name": "XRCC6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "XRCC6; G22P1; KU70", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA repair protein Ku70; 4.2.99.18; 5'-dRP/AP lyase Ku70; 5'-deoxyribose-5-phosphate lyase Ku70; 5.6.2.4; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; DNA repair protein XRCC6; Ku autoantigen protein p70 homolog; Ku70; X-ray repair cross-complementing protein 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395767); (R-GGA-353423)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10757784;12509254;14561766;18046455;22529269;9736627", "class_list": "", "function": "DNA-binding protein critical for the DNA damage response, specifically in repairing double-strand breaks (DSBs) via the classical non-homologous end joining (NHEJ) pathway. It forms a heterodimer with XRCC5 (Ku80), creating the Ku70:Ku80 heterodimer (Ku complex), which serves as a DNA end-binding complex. It primarily binds DSBs and recruits essential repair factors, assembling the core long-range NHEJ complex to facilitate the alignment and ligation of broken DNA ends. This pathway ensures the rapid repair of cytotoxic and mutagenic DSBs and contributes to the generation of diversity in T-cell receptors and antibodies through mechanisms such as V(D)J recombination. Likely acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), catalyzing the beta-elimination of the 5'-deoxyribose-5-phosphate at abasic sites near DSBs. This activity cleans the termini of abasic sites, a common form of nucleotide damage, preparing broken ends for ligation. It may also possess 3'-5' DNA helicase activity, although this has not been confirmed in vivo, and its physiological significance remains unclear. Beyond DNA repair, the protein contributes to telomere maintenance. It is also implicated in transcriptional regulation, acting as a cofactor for various transcription factors. It plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Can also bind RNAs and recruits PRKDC to a wide range of cellular RNAs, including the U3 small nucleolar RNA, playing a role in the biogenesis of ribosomal RNAs. Additionally, it negatively regulates apoptosis by interacting with BAX, sequestering it from the mitochondria, and may possess deubiquitination activity targeting BAX., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;4.2.99.18;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;2.7.11.1;7.2.2.-;3.2.2.-;3.6.5.-;2.7.7.7;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-;6.5.1.1", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:1990904 ribonucleoprotein complex;GO:0043564 Ku70:Ku80 complex", "go_biological_process": "GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O93257-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O93327-2", "uniprot_id": "H2AY_CHICK", "mass": 39210.0, "length": 369, "protein_name": "Core histone macro-H2A.1", "gene_name": "MACROH2A1", "organism": "Chicken", "refseq_name": "core histone macro-H2A.1", "refseq_ac": "NP_990338", "gene_names_uniprotkb": "MACROH2A1", "gene_names_refseq": "H2AFYMACROH2A1; H2AFY; MACROH2A1", "protein_names_uniprotkb": "Core histone macro-H2A.1; H2A.y; H2A/y; Histone macroH2A1; mH2A1", "protein_names_refseq": "H2A histone family, member Y; H2A.y; H2A/y; core histone macro-H2A.1; histone macroH2A1.2; mH2A1", "tax_id": 9031, "disease": "", "pathway": " (gga:395858)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15718235;9611225", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF058446.1, HAEL01005375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1., [RefSeq]; In contrast to isoform 1, does not bind poly-ADP-ribose., [UniProtKB, UniProtKB]; Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism. Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them. This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration., [UniProtKB, UniProtKB]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O93326", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0072570 ADP-D-ribose binding;GO:0030527 structural constituent of chromatin;GO:0160002 ADP-D-ribose modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006334 nucleosome assembly;GO:0031507 heterochromatin formation;GO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:1902688 regulation of NAD metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O93327-2", "record_type": "protein" }, { "uniprot_canonical_ac": "O93344-1", "uniprot_id": "AL1A2_CHICK", "mass": 56732.0, "length": 518, "protein_name": "Retinal dehydrogenase 2", "gene_name": "ALDH1A2", "organism": "Chicken", "refseq_name": "retinal dehydrogenase 2 isoform 1", "refseq_ac": "NP_990326", "gene_names_uniprotkb": "ALDH1A2; RALDH2", "gene_names_refseq": "ALDH1A2; RALDH(II); RALDH2", "protein_names_uniprotkb": "Retinal dehydrogenase 2; 1.2.1.36; ALDH1A2; Aldehyde dehydrogenase family 1 member A2; RALDH 2; RALDH(II); RalDH2; Retinaldehyde-specific dehydrogenase type 2", "protein_names_refseq": "aldehyde dehydrogenase 1A2; aldehyde dehydrogenase family 1 member A2; retinal dehydrogenase 2 isoform 1; retinal dehydrogenase 2; retinaldehyde dehydrogenase 2; retinaldehyde-specific dehydrogenase type 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395844)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22323456;22733143;9727493", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01015009.1, AF181680.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000245.1. On Dec 17, 2020 this sequence version replaced NP_990326.1., [RefSeq]; Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (By similarity). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Lacks activity with benzaldehyde, acetaldehyde and octanal (By similarity). Displays complete lack of activity with citral (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RALDH2 mediates meiosis initiation in germ cells of the female embryonic chickens., [RefSeq, PubMed]; Results of this study suggest that RALDH2 is the major retinal dehydrogenase in the chick choroid and is responsible for increased atRA synthesis in response to myopic defocus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q549A6", "ec_number_list": "1.5.1.6;1.2.1.36;1.2.1.19;1.2.1.3;1.2.1.28", "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0051289 protein homotetramerization;GO:0006081 aldehyde metabolic process;GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O93344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O93385-1", "uniprot_id": "PITX2_CHICK", "mass": 36558.0, "length": 333, "protein_name": "Pituitary homeobox 2", "gene_name": "PITX2", "organism": "Chicken", "refseq_name": "pituitary homeobox 2", "refseq_ac": "NP_990341", "gene_names_uniprotkb": "PITX2; PTX2", "gene_names_refseq": "PITX2; Ptx2", "protein_names_uniprotkb": "Pituitary homeobox 2; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2; cPITX2", "protein_names_refseq": "cPITX2; homeobox protein PITX2; paired-like homeodomain transcription factor 2; pituitary homeobox 2; transcription factor Pitx2", "tax_id": 9031, "disease": "", "pathway": " (gga:395862)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17959721;18647663;21259014;25482882;25496870;9347917;9636662", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF076640.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1. On Sep 23, 2021 this sequence version replaced NP_990341.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Downregulation of PITX2 and LEF1 genes may interfere with ventral body wall formation in Cd chick model causing omphalocele by disrupting somite myogenesis., [RefSeq, PubMed]; May play a role in myoblast differentiation. May be involved in the establishment of left-right asymmetry in the developing embryo (By similarity). May play a role in vasculogenesis during avian embryogenesis., [UniProtKB, UniProtKB]; Mechanism in females that actively promotes the underlying L-R asymmetry initiated by Pitx2 and the degeneration of the right gonad, and a mechanism in males that allows it to be ignored or overridden., [RefSeq, PubMed]; Pitx2 is essential for axis formation, and that it acts as a direct regulator of cVg1 expression by binding to enhancers within neighbouring genes. Publication Status: Online-Only, [RefSeq, PubMed]; Pitx2 is together with Pax6 expressed in the entire domain of the Rathke's pouch., [RefSeq, PubMed]; Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O73854;Q9PWE0", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000287 positive regulation of myotome development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030326 embryonic limb morphogenesis;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O93385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "O93574-1", "uniprot_id": "RELN_CHICK", "mass": 361294.0, "length": 3209, "protein_name": "Reelin", "gene_name": "RELN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RELN", "gene_names_refseq": "", "protein_names_uniprotkb": "Reelin; 3.4.21.-", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10861519", "class_list": "", "function": "Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 19, "predicted_n_glycosites": 18, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0070325 lipoprotein particle receptor binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0031012 extracellular matrix;GO:0043005 neuron projection", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0001764 neuron migration;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O93574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00504-1", "uniprot_id": "AATC_CHICK", "mass": 45935.0, "length": 412, "protein_name": "Aspartate aminotransferase, cytoplasmic", "gene_name": "GOT1", "organism": "Chicken", "refseq_name": "aspartate aminotransferase, cytoplasmic", "refseq_ac": "NP_990652", "gene_names_uniprotkb": "GOT1", "gene_names_refseq": "GOT1; cAspAT; cCAT", "protein_names_uniprotkb": "Aspartate aminotransferase, cytoplasmic; 2.6.1.1; 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; Glutamate oxaloacetate transaminase 1; Transaminase A; cAspAT; cCAT", "protein_names_refseq": "aspartate aminotransferase, cytoplasmic; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1; glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); transaminase A", "tax_id": 9031, "disease": "", "pathway": " (gga:396261); (R-GGA-352875); (R-GGA-372568); (R-GGA-8963693); (R-GGA-9856872)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "1593633;16287166;2110163;2401287;2503046;2985560;3094011;3539098;3885220;4463937;499525;6303388;6345546;7067826;7360247;7629021;7768978;7897655;8182283;9434147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000746.1, HAEK01025905.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000232.1., [RefSeq]; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.6.1.1;2.6.1.3;2.6.1.7", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity;GO:0004609 phosphatidylserine decarboxylase activity;GO:0047801 L-cysteine transaminase activity;GO:0120554 2-aminobutanoate transaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006533 L-aspartate catabolic process;GO:0006536 glutamate metabolic process;GO:0032869 cellular response to insulin stimulus;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P00504-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00508-1", "uniprot_id": "AATM_CHICK", "mass": 47241.0, "length": 423, "protein_name": "Aspartate aminotransferase, mitochondrial", "gene_name": "GOT2", "organism": "Chicken", "refseq_name": "aspartate aminotransferase, mitochondrial precursor", "refseq_ac": "NP_990854", "gene_names_uniprotkb": "GOT2", "gene_names_refseq": "GOT2", "protein_names_uniprotkb": "Aspartate aminotransferase, mitochondrial; 2.6.1.1; 2.6.1.7; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Transaminase A; mAspAT", "protein_names_refseq": "aspartate aminotransferase, mitochondrial precursor; aspartate aminotransferase, mitochondrial; glutamate oxaloacetate transaminase 2; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; mAspAT; transaminase A", "tax_id": 9031, "disease": "", "pathway": " (gga:396533); (R-GGA-352875); (R-GGA-372568)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "1593633;16287166;2110163;21803047;2401287;2985560;3094011;3539098;3840803;3885220;4463937;499525;6303388;6345546;7629021;7768978;7903048;8182283;8665890;8952476;9434147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01006488.1, SRR13267657.7884.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992470, SAMN04013384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000247.1. On Sep 23, 2021 this sequence version replaced NP_990854.1., [RefSeq]; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism., [UniProtKB, UniProtKB]; The modeling and comparison with the cytosolic isoform indicated that two residues (Arg201 and Ala219) were likely to be important to the structure and function of the binding site., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.6.1.63;2.6.1.39;2.6.1.7;2.6.1.4;2.6.1.73;2.6.1.1;4.4.1.13;2.6.1.64;2.6.1.3", "go_molecular_function": "GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006533 L-aspartate catabolic process;GO:0006536 glutamate metabolic process;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P00508-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00698-1", "uniprot_id": "LYSC_CHICK", "mass": 16239.0, "length": 147, "protein_name": "Lysozyme C", "gene_name": "LYZ", "organism": "Chicken", "refseq_name": "lysozyme C precursor", "refseq_ac": "NP_990612", "gene_names_uniprotkb": "LYZ", "gene_names_refseq": "LYZC; LYZ; dystrophin", "protein_names_uniprotkb": "Lysozyme C; 1,4-beta-N-acetylmuramidase C; 3.2.1.17; Allergen Gal d IV", "protein_names_refseq": "1,4-beta-N-acetylmuramidase C; allergen Gal d IV; egg white lysozyme; lysozyme (renal amyloidosis); lysozyme C precursor; lysozyme C", "tax_id": 9031, "disease": "", "pathway": " (gga:396218); (R-GGA-5653890); (R-GGA-6798695); (R-GGA-6803157)", "pathway_count": 4, "publication_count": 27, "publication_id_list": "10894169;11788708;1255711;1255720;14063294;14301784;15592404;1712773;19801983;19845599;22044478;28835461;31377191;31439662;32045632;33002360;3325501;3349024;33579016;33725478;37053565;383714;5857373;5891407;6934509;893412;9220986", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01135275.1, BX258259.4 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Sep 23, 2021 this sequence version replaced NP_990612.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; AIE-Based Dynamic in Situ Nanoscale Visualization of Amyloid Fibrillation from Hen Egg White Lysozyme., [RefSeq, PubMed]; Analysis of how lysozyme dipole-dipole interactions between tryptophan side chains and hydration water molecules dominate the observed dynamic stokes shift, [RefSeq, PubMed]; Lysozyme Fibrils Alter the Mechanism of Insulin Amyloid Aggregation. Publication Status: Online-Only, [RefSeq, PubMed]; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus., [UniProtKB, UniProtKB, PubMed]; Polyamines and its analogue modulates amyloid fibrillation in lysozyme: A comparative investigation., [RefSeq, PubMed]; The polyphosphate-bound, structurally destabilized egg white lysozyme molecules then start assembling into insoluble amorphous aggregates once they pass the solubility limit., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8YJN9;B8YJP1;B8YJT7;B8YK79;Q90884", "ec_number_list": "3.1.3.16;3.1.6.4;3.4.21.4;2.3.3.8;2.7.11.13;3.2.1.31;3.1.3.48;4.1.2.13;3.4.19.9;3.2.1.166;3.5.1.3;3.4.14.1;2.3.2.5;3.1.6.8;1.8.3.2;2.4.1.90;6.3.4.21;3.3.2.6;5.3.4.1;2.7.1.35;3.6.4.6;1.11.1.27;3.2.1.51;3.2.1.-;2.7.10.2;3.4.24.35;3.2.1.23;3.5.4.5;3.6.5.2;3.4.21.41;1.1.1.42;1.6.5.5;2.7.11.24;1.4.3.-;3.4.14.2;5.3.99.3;3.6.1.6;2.4.1.1;3.4.24.7;3.1.6.14;3.5.4.4;5.4.2.2;3.5.1.26;3.2.1.52;3.2.1.17;1.16.3.1;3.1.27.-;3.4.23.5;5.3.99.2;3.5.1.23", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003796 lysozyme activity;GO:0016231 beta-N-acetylglucosaminidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0016998 cell wall macromolecule catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P00698-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00789-1", "uniprot_id": "CANX_CHICK", "mass": 80352.0, "length": 705, "protein_name": "Calpain-1 catalytic subunit", "gene_name": "", "organism": "Chicken", "refseq_name": "calpain-1 catalytic subunit", "refseq_ac": "NP_990634", "gene_names_uniprotkb": "", "gene_names_refseq": "CANP; CAPN11; mu/m-CAPN; mu/mCAPN", "protein_names_uniprotkb": "Calpain-1 catalytic subunit; 3.4.22.52; CANP; Calcium-activated neutral proteinase; Calpain-1 large subunit; Mu/M-type", "protein_names_refseq": "calcium-activated neutral proteinase; calpain-1 catalytic subunit; calpain-1 large subunit; mu/M-type", "tax_id": 9031, "disease": "", "pathway": " (gga:396240)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17681928;18727211;3000828;3038855;6095110;7742367", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X01415.1, EF507731.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X01415.1., [RefSeq]; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction., [UniProtKB]; Results showed that CAPN1 gene may be the major gene affecting the tenderness traits of chicken or it links with the major gene, and the the polymorphic site may be used as molecular markers for meat tenderness and chicken quality., [RefSeq, PubMed]; The CAPN1 gene has been associated with meat quality traits in chicken., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P00789-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P00940-1", "uniprot_id": "TPIS_CHICK", "mass": 26620.0, "length": 248, "protein_name": "Triosephosphate isomerase", "gene_name": "TPI1", "organism": "Chicken", "refseq_name": "triosephosphate isomerase", "refseq_ac": "NP_990782", "gene_names_uniprotkb": "TPI1", "gene_names_refseq": "TIM; TPI1", "protein_names_uniprotkb": "Triosephosphate isomerase; 4.2.3.3; 5.3.1.1; Methylglyoxal synthase; TIM; Triose-phosphate isomerase", "protein_names_refseq": "methylglyoxal synthase; triose-phosphate isomerase; triosephosphate isomerase (TIM, D-glyceraldehyde 3-phosphate ketol-isomerase); triosephosphate isomerase", "tax_id": 9031, "disease": "", "pathway": " (gga:396435); (R-GGA-352875); (R-GGA-352882); (R-GGA-70171); (R-GGA-70263)", "pathway_count": 5, "publication_count": 26, "publication_id_list": "1134550;1569570;1593633;16287166;17336327;17455914;18189421;2110163;2361134;2985560;3094011;3539098;3837846;3885220;4463937;499525;6303388;6345546;6574503;7629021;7768978;7916593;8130195;8182283;9434147;985462", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M11314.1, CO635757.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M11314.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; 1st essential mode contributing to 34% of overall motion of dimer is strongly coupled to loop 6's closure over active site. Onset of collective motions at ns time scale due to dimerization has functional implications as to coordination of loop 6 closure., [RefSeq, PubMed]; It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids., [UniProtKB, UniProtKB]; NMR study of wild-type (WT) TIM and a quintuple mutant (PGG/GGG)., [RefSeq, PubMed]; There is clear evidence for motion with an exchange rate constant consistent with opening and closing of triosephosphate isomerase active site loop (loop 6) being partially rate-limiting to catalytic throughput., [RefSeq, PubMed]; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.1.1;4.2.3.3", "go_molecular_function": "GO:0004807 triose-phosphate isomerase activity;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0008929 methylglyoxal synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0019242 methylglyoxal biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P00940-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01005-1", "uniprot_id": "IOVO_CHICK", "mass": 22591.0, "length": 210, "protein_name": "Ovomucoid", "gene_name": "", "organism": "Chicken", "refseq_name": "ovomucoid isoform 1 precursor", "refseq_ac": "NP_001295423", "gene_names_uniprotkb": "", "gene_names_refseq": "OM; OVM; SPIK7; SPINK7", "protein_names_uniprotkb": "Ovomucoid; Allergen Gal d I", "protein_names_refseq": "allergen Gal d 1; allergen Gal d I; ovomucoid isoform 1 precursor; ovomucoid", "tax_id": 9031, "disease": "", "pathway": " (gga:416236)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10833030;11944924;15253437;17573723;19533036;23075397;27050479;32909666;3548816;435257;6826553;7130179;721826;7430252;9257870", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: J00902.1, HAEL01010332.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992482, SAMEA103992527 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000256.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that both ovalbumin and ovomucoid were efficiently mutagenized in cultured primordial germ cells (PGCs) by CRISPR/Cas9 system. Publication Status: Online-Only, [RefSeq, PubMed]; Demonstrate that ovomuccoid mRNA has a 24 aa leader sequence and that ovomuccoid but not pre-ovomuccoid has trypsin inhibition activity, [RefSeq, PubMed]; Serine protease inhibitor. Inhibits trypsin., [UniProtKB, PubMed]; The preferred order of intron removals can be described by a consideration of free energy changes involved in the spliceosomal assembly pathway., [RefSeq, PubMed]; Turtle-dove (Streptopelia risoria) ovomucoid is differentiated from chicken ovomucoid as it inhibits both trypsin and chymotrypsin to some extent; chick ovomucoid has no effect on chymotrypsin, but completely inhibits trypsin., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 23, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 64, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019863 IgE binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030246 carbohydrate binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0032991 protein-containing complex", "go_biological_process": "GO:0048545 response to steroid hormone", "synthesized_glycan_count": 0, "hit_score": 8.3, "record_id": "P01005-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01012-1", "uniprot_id": "OVAL_CHICK", "mass": 42881.0, "length": 386, "protein_name": "Ovalbumin", "gene_name": "SERPINB14", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SERPINB14", "gene_names_refseq": "", "protein_names_uniprotkb": "Ovalbumin; Allergen Gal d II; Egg albumin; Plakalbumin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396058); (R-GGA-6798695); (R-GGA-8939242)", "pathway_count": 3, "publication_count": 198, "publication_id_list": "10449165;10477598;10570269;10602017;10671225;10833030;10915575;11385623;11390600;11394501;11466344;11581168;11710934;11779232;11931671;12407019;12538696;12874211;12902504;12910264;12927080;12938211;12965258;1319610;14600204;14741703;14978103;15302863;15379861;15489266;15494519;15814688;15925833;15951824;16052529;16455975;16552058;16709853;16879259;1689012;16951365;17072910;17114426;17236828;17553613;17698646;17709425;17719490;18182487;18193057;18292507;18612271;18922097;18929574;19017950;19022223;19180468;19188498;19358553;1942038;19428921;19541644;19542448;19748894;19892989;19949110;20006892;20007267;20082619;20411564;20439913;20512973;20538860;20616089;21098221;21157435;21264321;21264852;21389617;21490153;21625449;21674137;21742967;21949026;21962492;21963602;22007143;22037570;22039305;22089830;22301693;22706385;22733018;22745779;22809501;22821960;22862959;22948808;22949678;22987800;23029192;23041566;23047087;23056200;23267026;23382674;23455500;2352279;23686484;23953841;2395463;24052528;24068737;24205056;24211184;24244658;2453917;24717441;24877765;24967892;25070853;25115805;25267651;25348595;25436390;25450389;25601203;25784151;26171764;26312056;26606283;26928966;272676;27332899;27732841;28270614;28469082;29132960;29175591;29314611;29599287;29673645;30005865;30143632;30183073;30451992;30848361;31324690;32106283;32184297;32418793;32561966;32582572;32594746;32701257;32733483;32745153;33205941;33725478;3410855;34141869;34145076;34368641;34452929;35196075;35217098;35459734;35803932;37161052;37217939;3732511;37586771;38338542;423993;6272839;661981;6731806;6749856;6783411;692731;7139658;7483809;751624;751625;7539039;7733678;7947455;7950407;7972089;8303944;8370082;8889264;9151706;9418131;9469429;9531271;9566759;9770520", "class_list": "", "function": "Non-inhibitory serpin. Storage protein of egg white., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 29, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 71, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q804A4;Q90741", "ec_number_list": "", "go_molecular_function": "GO:0002020 protease binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006811 monoatomic ion transport;GO:0032570 response to progesterone;GO:0048545 response to steroid hormone;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 27.3, "record_id": "P01012-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P01109-1", "uniprot_id": "MYC_CHICK", "mass": 47806.0, "length": 435, "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "organism": "Chicken", "refseq_name": "myc proto-oncogene protein isoform 1", "refseq_ac": "NP_001026123", "gene_names_uniprotkb": "MYC", "gene_names_refseq": "MYC; c-myc", "protein_names_uniprotkb": "Myc proto-oncogene protein; c-Myc", "protein_names_refseq": "MYC proto-oncogene, bHLH transcription factor; myc proto-oncogene protein isoform 1; myc proto-oncogene protein; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein", "tax_id": 9031, "disease": "", "pathway": " (gga:420332); (R-GGA-5689880); (R-GGA-8866911)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1628829;24371071;24599748;25528440;2841585;29158522;6087343;6300896", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.257735.1, SRR13267647.7010.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000044.1. On or before Dec 10, 2021 this sequence version replaced XP_015138575.1, XP_418439.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; An unexpected role of MYC proteins in the control of stemness versus differentiation of neural stem cells in vivo., [RefSeq, PubMed]; MYC, TERT, and ZIC1 genes are common targets of viral integration., [RefSeq, PubMed]; Marek's disease virus microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-beta signaling pathway., [RefSeq, PubMed]; These data indicated that miR-17-92 promotes chicken cell proliferation at least in part by the upregulation of c-Myc via targeting MAP3K2, and the miR-17-92 cluster, c-Myc and E2F1 form a complex regulatory network in chicken cell proliferation Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0044877 protein-containing complex binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P01109-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02259-1", "uniprot_id": "H5_CHICK", "mass": 20734.0, "length": 190, "protein_name": "Histone H5", "gene_name": "", "organism": "Chicken", "refseq_name": "histone H5", "refseq_ac": "NP_001038138", "gene_names_uniprotkb": "", "gene_names_refseq": "H-10; H1-0; H1F0; H5", "protein_names_uniprotkb": "Histone H5", "protein_names_refseq": "H1 histone family, member 0; histone H5", "tax_id": 9031, "disease": "", "pathway": " (gga:693250); (R-GGA-140342); (R-GGA-2559584)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "1112411;1112412;11859148;21656257;27558112;3463990;6252059;6300759;6315952;7371850;7935495;8384699", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: HAEK01012473.1, BX265445.4 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that a promotion of chromatin folding in terminally differentiated avian blood cells requires the presence of either histone H5 in erythrocytes or myeloid and erythroid nuclear termination stage-specific protein (MENT) in white blood cells. Review article, [RefSeq, PubMed]; Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells., [UniProtKB]; Taken together, these results suggest that a small number of residues in the globular domain of a linker histone can control its binding location on the nucleosome and higher-order chromatin structure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P02259-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02460-1", "uniprot_id": "CO2A1_CHICK", "mass": 83228.0, "length": 859, "protein_name": "Collagen alpha-1(II) chain", "gene_name": "COL2A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "COL2A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(II) chain; Alpha-1 type II collagen", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15592404;3840018;6330084", "class_list": "", "function": "Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PJB4", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02467-1", "uniprot_id": "CO1A2_CHICK", "mass": 128995.0, "length": 1363, "protein_name": "Collagen alpha-2(I) chain", "gene_name": "COL1A2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "COL1A2", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-2(I) chain; Alpha-2 type I collagen", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 18, "publication_id_list": "15592404;364479;3678834;3868961;4313735;5443711;5443712;5544653;5785233;5809220;6135195;6159982;6267043;6272119;6473103;6927845;6946474;7460017", "class_list": "", "function": "Type I collagen is a member of group I collagen (fibrillar forming collagen)., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 1, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "F1P0H9;P87491;P87492;Q90758;Q90792;Q90795;Q90797;Q92014", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005584 collagen type I trimer;GO:0005583 fibrillar collagen trimer", "go_biological_process": "GO:0001501 skeletal system development;GO:0030199 collagen fibril organization;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P02467-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02552-1", "uniprot_id": "TBA1A_CHICK", "mass": 50136.0, "length": 451, "protein_name": "Tubulin alpha-1A chain", "gene_name": "TUBA1A", "organism": "Chicken", "refseq_name": "tubulin alpha-1A chain", "refseq_ac": "NP_001292201", "gene_names_uniprotkb": "TUBA1A", "gene_names_refseq": "TUBA1A; TUBA1; TUBA6", "protein_names_uniprotkb": "Tubulin alpha-1A chain; 3.6.5.-", "protein_names_refseq": "tubulin alpha-1 chain; tubulin alpha-1A chain; tubulin, alpha 1 (testis specific); tubulin, alpha 6", "tax_id": 9031, "disease": "", "pathway": " (gga:429035)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "4519648;7464932", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01005040.1, HAEL01000908.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000490.1, BI390672.1, BI390841.1 and BI392270.1. On Nov 27, 2021 this sequence version replaced NP_001292201.1., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P02552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02565-1", "uniprot_id": "MYH1B_CHICK", "mass": 222817.0, "length": 1940, "protein_name": "Myosin-1B", "gene_name": "MYH1B", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYH1B; MYH3", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-1B; Myosin heavy chain 1B, skeletal muscle; Myosin heavy chain 3; Myosin heavy chain, fast skeletal muscle, embryonic; Myosin-3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2997212;3571266;6833296", "class_list": "", "function": "Muscle contraction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016460 myosin II complex", "go_biological_process": "GO:0006936 muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02565-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02607-1", "uniprot_id": "MYL6_CHICK", "mass": 16987.0, "length": 151, "protein_name": "Myosin light polypeptide 6", "gene_name": "MYL6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYL6", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin light polypeptide 6; G2 catalytic; LC17-GI; LC17-NM; Myosin light chain alkali smooth-muscle/non-muscle isoforms", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "3038890;6870825;7319048;9741621", "class_list": "", "function": "Regulatory light chain of myosin. Does not bind calcium., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08296", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0000287 magnesium ion binding;GO:0043531 ADP binding;GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005829 cytosol;GO:0042641 actomyosin;GO:0097513 myosin II filament;GO:0016460 myosin II complex", "go_biological_process": "GO:0031032 actomyosin structure organization;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02607-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02640-1", "uniprot_id": "VILI_CHICK", "mass": 92479.0, "length": 826, "protein_name": "Villin-1", "gene_name": "VIL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "VIL1; VIL", "gene_names_refseq": "", "protein_names_uniprotkb": "Villin-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396423)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15894611;16142894;1618806;2839826;3793760;6790532;6848508;8142900;9164455;9194180", "class_list": "", "function": "Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Its actin-bundling activity is inhibited by tropomyosin., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0001726 ruffle;GO:0005902 microvillus", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0061041 regulation of wound healing;GO:0051125 regulation of actin nucleation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02640-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02701-1", "uniprot_id": "AVID_CHICK", "mass": 16768.0, "length": 152, "protein_name": "Avidin", "gene_name": "AVD", "organism": "Chicken", "refseq_name": "avidin precursor", "refseq_ac": "NP_990651", "gene_names_uniprotkb": "AVD", "gene_names_refseq": "AVD", "protein_names_uniprotkb": "Avidin", "protein_names_refseq": "avidin precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396260)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11167523;1898347;2143802;2386489;25002549;25630677;3575102;5100762;5100763;6816268;7665080;8506353;8515446;9760187", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CF252815.1, CF252572.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000087.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The biological function of avidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of avidin)., [UniProtKB]; The effect of biotin supplementation on avidin-related protein-2 (AVR2) expression, and the relationship between biotin administration and oviductal expression of avidin and AVR2, was dependent on the hen's age, being higher in the young hens., [RefSeq, PubMed]; The fertility rate and oviductal expression of avidin and AVR2 were dichotomously affected by oral biotin in low- and high-fertility line hens, where only low-fertility birds showed improvements in these attributes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 140, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91958;Q98SH4", "ec_number_list": "", "go_molecular_function": "GO:0009374 biotin binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P02701-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02752-1", "uniprot_id": "RBP_CHICK", "mass": 27211.0, "length": 238, "protein_name": "Riboflavin-binding protein", "gene_name": "", "organism": "Chicken", "refseq_name": "riboflavin-binding protein precursor", "refseq_ac": "NP_990794", "gene_names_uniprotkb": "", "gene_names_refseq": "RBP; RTBDN; Rd", "protein_names_uniprotkb": "Riboflavin-binding protein; RBP", "protein_names_refseq": "retbindin; riboflavin-binding protein precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396449)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10833030;15488765;15713531;1637312;17167172;23334913;3403518;3571203;3997791;4091257;6469943;8226844;8370663", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: J03922.1, BU125835.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU267624.1 and J03922.1. Sequence Note: This RefSeq record was created from transcripts of different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Both the hydration and surface charge of the confining volume is expected to largely determine the biochemical reaction dynamics of the riboflavin-binding protein., [RefSeq, PubMed]; Data estimate not only the thermostability of both N- and C-terminal domains of riboflavin-binding protein but also the strength of domain interactions., [RefSeq, PubMed]; Required for the transport of riboflavin to the developing oocyte., [UniProtKB]; The selectivity in the sweet suppression by RBP is consistent with the existence of multiple interaction sites within a single sweet taste receptor., [RefSeq, PubMed]; Using moxestrol and riboflavin carrier protein promoter/reporter constructs in chicken hepatoma cells, an estrogen response unit (ERU) composed of two consensus ERE 1/2 sites and one non-consensus ERE 1/2 site was identified ., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 25, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 72, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7T3Y1", "ec_number_list": "", "go_molecular_function": "GO:0032217 riboflavin transmembrane transporter activity;GO:1902444 riboflavin binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032218 riboflavin transport;GO:1904657 negative regulation of sensory perception of sweet taste;GO:1904661 negative regulation of sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 8.9, "record_id": "P02752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02789-1", "uniprot_id": "TRFE_CHICK", "mass": 77777.0, "length": 705, "protein_name": "Ovotransferrin", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ovotransferrin; Allergen Gal d III; Conalbumin; Serum transferrin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396241)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10497206;10583947;1172663;25436390;32909666;3658709;4907959;574451;649604;6895872;7060577;7490743;7881176;7986092;8218271", "class_list": "", "function": "Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 7, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:1990377 organomineral extracellular matrix", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0019731 antibacterial humoral response;GO:0032496 response to lipopolysaccharide;GO:0006879 intracellular iron ion homeostasis;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P02789-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02822-1", "uniprot_id": "OSTCN_CHICK", "mass": 10707.0, "length": 97, "protein_name": "Osteocalcin", "gene_name": "BGLAP", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BGLAP", "gene_names_refseq": "", "protein_names_uniprotkb": "Osteocalcin; BGP; Bone Gla protein; Gamma-carboxyglutamic acid-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "6792200;7747623", "class_list": "", "function": "The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (PubMed:6792200). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90620", "ec_number_list": "", "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:1903011 negative regulation of bone development;GO:0032869 cellular response to insulin stimulus;GO:0042593 glucose homeostasis;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P02822-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P02845-1", "uniprot_id": "VIT2_CHICK", "mass": 204808.0, "length": 1850, "protein_name": "Vitellogenin-2", "gene_name": "VTG2", "organism": "Chicken", "refseq_name": "vitellogenin-2 precursor", "refseq_ac": "NP_001026447", "gene_names_uniprotkb": "VTG2; VTGII", "gene_names_refseq": "VIT2; VTG2; vitellogenin-2; vit", "protein_names_uniprotkb": "Vitellogenin-2; LVII; LVI; Lipovitellin II; Lipovitellin I; Major vitellogenin; Vitellogenin II", "protein_names_refseq": "major vitellogenin; vitellogenin II; vitellogenin-2 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:424533)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "23103859;23474079;2494348;34281277;3477646;3680202;4065410;6091745;6199194;6694908;7599159", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992290 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1. On Oct 17, 2021 this sequence version replaced NP_001026447.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; C-Terminal Fragment of Vitellogenin II, a Potential Yolkin Polypeptide Complex Precursor Protein-Heterologous Expression, Purification, and Immunoregulatory Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that hepatocellular carcinoma LMH cells transfected with a reporter construct bearing the vitellogenin promoter is a useful model for the study of hydrocarbon receptor (AHR)-estrogen receptor (ER) interaction in liver-derived cells., [RefSeq, PubMed]; For the first time generated a large number of phosphopeptides (~100) and identified 151 phosphorylation sites of phosvitin 1 and phosvitin 2, respectively. Importantly, this study also led to the discovery of a novel phosvitin 1, [RefSeq, PubMed]; Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo., [UniProtKB]; Precursor of the major egg-yolk proteins that are sources of nutrients during early development of oviparous organisms., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q6LBT2;Q91026;Q91027", "ec_number_list": "", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0045735 nutrient reservoir activity", "go_cellular_component": "", "go_biological_process": "GO:0032355 response to estradiol;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P02845-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05153-1", "uniprot_id": "PCKGC_CHICK", "mass": 69528.0, "length": 622, "protein_name": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]", "gene_name": "PCK1", "organism": "Chicken", "refseq_name": "phosphoenolpyruvate carboxykinase, cytosolic [GTP]", "refseq_ac": "NP_990802", "gene_names_uniprotkb": "PCK1", "gene_names_refseq": "PCK1; PEPCK", "protein_names_uniprotkb": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; 2.7.11.-; 4.1.1.32; PEPCK-C; Serine-protein kinase PCK1", "protein_names_refseq": "PEPCK-C; cytosolic phosphoenolpyruvate carboxykinase; phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxylase; serine-protein kinase PCK1", "tax_id": 9031, "disease": "", "pathway": " (gga:396458); (R-GGA-352875)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "1593633;16287166;2110163;23544081;23770670;24046422;2985560;3094011;3539098;3885220;4463937;499525;6303388;6345546;7629021;7768978;8182283;9434147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M14229.1, SRR12888528.194751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992559, SAMEA103992604 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. On Sep 23, 2021 this sequence version replaced NP_990802.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A fast-growing chicken breed had significantly higher hepatic mRNA expression levels of the cytosolic form of PEPCK and significantly higher hepatic mRNA and protein expression levels of cAMP response element binding protein 1., [RefSeq, PubMed]; Androgen status negatively regulated the PCK1 gene in male chickens., [RefSeq, PubMed]; Data indicate that aryl hydrocarbon receptor (AHR) enhances phosphoenolpyruvate carboxykinase (PEPCK) ADP-ribosylation through TiPARP TiPARP (TCDD-inducible poly(ADP-ribose) polymerase)., [RefSeq, PubMed]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.32;2.7.11.-", "go_molecular_function": "GO:0005525 GTP binding;GO:0030145 manganese ion binding;GO:0051379 epinephrine binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0046327 glycerol biosynthetic process from pyruvate;GO:0009792 embryo development ending in birth or egg hatching;GO:0019563 glycerol catabolic process;GO:0019953 sexual reproduction;GO:0007296 vitellogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P05153-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05180-1", "uniprot_id": "CP2H1_CHICK", "mass": 56261.0, "length": 491, "protein_name": "Cytochrome P450 2H1", "gene_name": "CYP2H1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CYP2H1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2H1; 1.14.14.1; CYPIIH1; Cytochrome P450 PB15; Cytochrome P450 PCHP3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:414746)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11572089;2424910", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.-;1.14.14.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0009410 response to xenobiotic stimulus;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P05200-1", "uniprot_id": "NGF_CHICK", "mass": 27138.0, "length": 243, "protein_name": "Beta-nerve growth factor", "gene_name": "NGF", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NGF; NGFB", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-nerve growth factor; Beta-NGF", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "2025430;2328722;2427334;3017695;3720959", "class_list": "", "function": "Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P05200-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P06212-1", "uniprot_id": "ESR1_CHICK", "mass": 66746.0, "length": 589, "protein_name": "Estrogen receptor", "gene_name": "ESR1", "organism": "Chicken", "refseq_name": "estrogen receptor", "refseq_ac": "NP_990514", "gene_names_uniprotkb": "ESR1; ESR; NR3A1", "gene_names_refseq": "ESR1", "protein_names_uniprotkb": "Estrogen receptor; ER-alpha; ER; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1", "protein_names_refseq": "ER-alpha; ER; estradiol receptor; estrogen receptor, alpha; estrogen receptor; nuclear receptor subfamily 3 group A member 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396099)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23342917;24704443;26519127;2901032;30704757;32087914;3755102", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X03805.1, HQ340611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X03805.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Differential expression of ER-alpha in both chicken ovaries during development in a cell type-specific distribution, suggesting that these differences may be regarded as an important cause in the process of asymmetric ovarian development in the chicken, [RefSeq, PubMed]; Differential expression of ER-alpha may contribute to regulate the reproductive function in the mature chicken or the cessation of reproductive function in aged chickens, [RefSeq, PubMed]; Epigenetic changes associated with increased estrogen receptor alpha mRNA transcript abundance during reproductive maturation in chicken ovaries., [RefSeq, PubMed]; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues., [UniProtKB]; The variations of ESR1 or PR expression or dominance of either PR expression is differentially regulated depending on the cell type in the chicken oviduct., [RefSeq, PubMed]; There were no significant differences in ERalpha mRNA expression during stress induced by fasting and refeeding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0005496 steroid binding;GO:0004879 nuclear receptor activity;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0071391 cellular response to estrogen stimulus;GO:0030520 estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P06212-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07751-1", "uniprot_id": "SPTN1_CHICK", "mass": 285363.0, "length": 2477, "protein_name": "Spectrin alpha chain, non-erythrocytic 1", "gene_name": "SPTAN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SPTAN1; SPTA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374234)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1279434;15522301;21358049;28112730;2910879;4029118;7588621;9356261;9699637", "class_list": "", "function": "Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0030864 cortical actin cytoskeleton;GO:0042995 cell projection;GO:0043034 costamere", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051693 actin filament capping", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07751-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07812-1", "uniprot_id": "PRGR_CHICK", "mass": 85744.0, "length": 786, "protein_name": "Progesterone receptor", "gene_name": "PGR", "organism": "Chicken", "refseq_name": "progesterone receptor", "refseq_ac": "NP_990593", "gene_names_uniprotkb": "PGR; NR3C3", "gene_names_refseq": "NR3C3; PGR", "protein_names_uniprotkb": "Progesterone receptor; Nuclear receptor subfamily 3 group C member 3; PR", "protein_names_refseq": "PR; nuclear receptor subfamily 3 group C member 3; progesterone receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:396198); (R-GGA-3371497); (R-GGA-383280); (R-GGA-4090294); (R-GGA-9018519)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "18229454;2303488;23913445;2398063;2426697;2426779;26519127;27526993;2760059;3153474;3443098;3453892;3653503;7877616;8662804;9808061", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y00092.1, M37518.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000027.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A side-by-side comparison of the Hsp90-dependent chaperoning of Chk1 to that of the progesterone receptor (PR) was performed to show that these distinct types of clients have different chaperoning requirements., [RefSeq, PubMed]; Data suggest that progesterone receptors A (PRA) and B (PRB) and progesterone receptor membrane component 1 (PGRMC1) are expressed in neurons of embryonic dorsal root ganglia., [RefSeq, PubMed]; The results indicate that PR percentage and the PR-A and PR-B ratio change according to the cell type of the oviduct magnum and in an age-specific manner., [RefSeq, PubMed]; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues., [UniProtKB]; The variations of ESR1 or PR expression or dominance of either PR expression is differentially regulated depending on the cell type in the chicken oviduct., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90946", "ec_number_list": "", "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0032570 response to progesterone;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P07812-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07898-1", "uniprot_id": "PGCA_CHICK", "mass": 223493.0, "length": 2109, "protein_name": "Aggrecan core protein", "gene_name": "ACAN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ACAN; AGC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Aggrecan core protein; CSPCP; Cartilage-specific proteoglycan core protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "1339285;1600245;1694853;2365711;3170613;3460082;7827752;8226878", "class_list": "", "function": "This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage., [UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 9, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 9, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 24, "binding_glycan_count": 0, "secondary_ac_list": "Q90810;Q90820;Q90991;Q91047", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P07898-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P07997-1", "uniprot_id": "HEM1_CHICK", "mass": 69948.0, "length": 635, "protein_name": "5-aminolevulinate synthase, non-specific, mitochondrial", "gene_name": "ALAS1", "organism": "Chicken", "refseq_name": "5-aminolevulinate synthase, non-specific, mitochondrial precursor", "refseq_ac": "NP_001018012", "gene_names_uniprotkb": "ALAS1; ALASN", "gene_names_refseq": "ALAS-E; ALAS1; ALAS2; ALASE; ALASN", "protein_names_uniprotkb": "5-aminolevulinate synthase, non-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 1; ALAS-H; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1", "protein_names_refseq": "5'-aminolevulinate synthase 2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinate synthase, non-specific, mitochondrial precursor; 5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; 5-aminolevulinic acid synthase 2; ALA-synthase; ALAS-H; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2; aminolevulinate, delta-, synthase 1; delta-ALA synthase 1; delta-aminolevulinate synthase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:552895); (R-GGA-421984)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16121195;2915978;3005973;3839458;9808757", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X02827.1, HAEK01002454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000252.1. On Sep 23, 2021 this sequence version replaced NP_001018012.1., [RefSeq]; Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.37", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003870 5-aminolevulinate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0042541 hemoglobin biosynthetic process;GO:1903412 response to bile acid", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08023-1", "uniprot_id": "ACTA_CHICK", "mass": 41995.0, "length": 377, "protein_name": "Actin, aortic smooth muscle", "gene_name": "ACTA2", "organism": "Chicken", "refseq_name": "actin, aortic smooth muscle", "refseq_ac": "NP_001026400", "gene_names_uniprotkb": "ACTA2", "gene_names_refseq": "ACTA2; asma", "protein_names_uniprotkb": "Actin, aortic smooth muscle; 3.6.4.-; Alpha-actin", "protein_names_refseq": "actin, aortic smooth muscle; alpha-actin", "tax_id": 9031, "disease": "", "pathway": " (gga:423787)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16648183;18688635;20157768;3013870", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01001461.1, HAEL01004499.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000231.1. On or before Dec 10, 2021 this sequence version replaced XP_015143877.1, NP_001026400.1., [RefSeq]; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; Pericytes in the mature chorioallantoic membrane capillary plexus contain desmin and alpha-smooth muscle actin: relevance for non-sprouting angiogenesis., [RefSeq, PubMed]; The distribution of laminin and alphaSMA in the testis and epididymis might point out to their roles in the male reproduction., [RefSeq, PubMed]; Thus the embryonic dorsal aorta is sensitive to increased arterial load and adapts by altering its material properties via changes in collagen and alpha-actin content., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium;GO:0044297 cell body", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0090131 mesenchyme migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08106-1", "uniprot_id": "HSP70_CHICK", "mass": 69751.0, "length": 634, "protein_name": "Heat shock 70 kDa protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock 70 kDa protein; HSP70", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423504)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3017985", "class_list": "", "function": "Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0033142 nuclear progesterone receptor binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0009409 response to cold;GO:0032570 response to progesterone;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P08106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08110-1", "uniprot_id": "ENPL_CHICK", "mass": 91555.0, "length": 795, "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "organism": "Chicken", "refseq_name": "endoplasmin precursor", "refseq_ac": "NP_989620", "gene_names_uniprotkb": "HSP90B1; HSPC4; TRA1", "gene_names_refseq": "HSP90B1; hsp108", "protein_names_uniprotkb": "Endoplasmin; 3.6.4.-; HSP 108; HSP108; Heat shock 108 kDa protein; Heat shock protein 90 kDa beta member 1; Transferrin-binding protein", "protein_names_refseq": "108K HSP; 108K heat shock protein; HSP 108; endoplasmin precursor; endoplasmin; heat shock 108 kDa protein; heat shock protein 108; heat shock protein 90 kDa beta member 1; transferrin-binding protein", "tax_id": 9031, "disease": "", "pathway": " (gga:374163)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "3024703;3027654;8166742", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M14772.1, AF387865.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992543 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Sep 23, 2021 this sequence version replaced NP_989620.1., [RefSeq]; ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q90869;Q90870", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0033018 sarcoplasmic reticulum lumen", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0006457 protein folding;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08110-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08317-1", "uniprot_id": "IL8_CHICK", "mass": 11056.0, "length": 103, "protein_name": "Interleukin-8", "gene_name": "CXCL8", "organism": "Chicken", "refseq_name": "interleukin-8 precursor", "refseq_ac": "NP_990829", "gene_names_uniprotkb": "CXCL8; CEF4; EMF1; IL8", "gene_names_refseq": "CEF4; CXCL8; CXCLi2; EMF-1; EMF1; IL8L2; IL8; chCXCLi2", "protein_names_uniprotkb": "Interleukin-8; 9E3; C-X-C motif chemokine 8; CEF-4; Chemokine (C-X-C motif) ligand 8; EMF-1; Embryo fibroblast protein 1; IL-8", "protein_names_refseq": "C-X-C motif chemokine 8; CEF-4/9E3 cytokine; IL-8; RSV-induced protein; chemokine (C-X-C motif) ligand 8; chemokine K60; embryo fibroblast protein 1; interleukin-8 precursor; putatitve interleukin-8; transformation-induced protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396495); (R-GGA-114608); (R-GGA-375276); (R-GGA-380108); (R-GGA-418594)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10369926;20337964;2821543;3032449;32349370", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: J02975.1, CF251843.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1. On Aug 30, 2004 this sequence version replaced XP_444659.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Lower levels in airway aspirates from breastfed infants with acute bronchiolitis, [RefSeq, PubMed]; May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils., [UniProtKB]; Study of the Relationship between Polymorphisms in the IL-8 Gene Promoter Region and Coccidiosis Resistance Index in Jinghai Yellow Chickens. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q546U2", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0048247 lymphocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P08317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08641-1", "uniprot_id": "CADH1_CHICK", "mass": 97783.0, "length": 887, "protein_name": "Cadherin-1", "gene_name": "CDH1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CDH1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-1; E-cadherin; Epithelial cadherin; L-CAM; Liver cell adhesion molecule", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:415860)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1638632;3174655;3472238", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Promotes organization of radial actin fiber structure and cellular response to contractile forces, via anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane (By similarity). E-cadherin is a ligand for integrin alpha-E/beta-7., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007416 synapse assembly;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P08641-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08642-1", "uniprot_id": "RASH_CHICK", "mass": 21365.0, "length": 189, "protein_name": "GTPase HRas", "gene_name": "HRAS", "organism": "Chicken", "refseq_name": "GTPase HRas", "refseq_ac": "NP_990623", "gene_names_uniprotkb": "HRAS; HRAS1", "gene_names_refseq": "H-RAS; H-Ras-1; HRAS1; HRAS; c-H-ras; p21ras", "protein_names_uniprotkb": "GTPase HRas; 3.6.5.2; H-Ras-1; Transforming protein p21; c-H-ras; p21ras", "protein_names_refseq": "GTPase HRas; transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ha-ras Harvey rat sarcoma viral oncogene-like protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396229); (R-GGA-1169092); (R-GGA-1250347); (R-GGA-1433557); (R-GGA-171007); (R-GGA-179812); (R-GGA-180336); (R-GGA-186763); (R-GGA-1963640); (R-GGA-210993); (R-GGA-2179392); (R-GGA-2424491); (R-GGA-2871796); (R-GGA-375165); (R-GGA-3928662); (R-GGA-5218921); (R-GGA-5621575); (R-GGA-5654688); (R-GGA-5654693); (R-GGA-5654699); (R-GGA-5654700); (R-GGA-5654704); (R-GGA-5654706); (R-GGA-5654712); (R-GGA-5654719); (R-GGA-5658442); (R-GGA-5673000); (R-GGA-5673001); (R-GGA-5674135); (R-GGA-5675221); (R-GGA-8849471); (R-GGA-8851805); (R-GGA-9607240); (R-GGA-9634635); (R-GGA-9648002)", "pathway_count": 35, "publication_count": 3, "publication_id_list": "19218240;28768863;3011401", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01139571.1, HAEK01029042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1., [RefSeq]; BLNK recruits active H-Ras to the BCR complex, which is essential for sustained surface expression of BCR in the form of the cap and for the signal leading to functional ERK activation, [RefSeq, PubMed]; Data describe the mechanisms of oncogenesis induced in chickens by the myeloblastosis-associated virus 2 retrovirus; analyses identified HRAS, EGFR, MET, and RON as insertionally mutagenized driver genes and characterized the mechanisms of their tumorigenic activation Publication Status: Online-Only, [RefSeq, PubMed]; Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;2.7.1.91;3.1.2.22;3.6.5.5;2.7.11.1;2.5.1.58;2.7.10.2;2.7.10.1;2.7.11.17;3.6.5.-;3.6.5.3;2.5.1.59;2.3.1.225;3.1.3.48;3.6.1.5;2.3.2.27;2.7.11.24;2.7.11.13;3.6.4.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043495 protein-membrane adaptor activity;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P08642-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08836-1", "uniprot_id": "FPPS_CHICK", "mass": 42153.0, "length": 367, "protein_name": "Farnesyl pyrophosphate synthase", "gene_name": "FDPS", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FDPS", "gene_names_refseq": "", "protein_names_uniprotkb": "Farnesyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.10; 2.5.1.1; Dimethylallyltranstransferase; FPP synthase; FPS; Farnesyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "7272273;8086404;8986756", "class_list": "", "function": "Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.5.1.1;2.5.1.10;2.5.1.29", "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0033384 geranyl diphosphate biosynthetic process;GO:0045337 farnesyl diphosphate biosynthetic process;GO:0006695 cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P08836-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P08941-1", "uniprot_id": "ROS1_CHICK", "mass": 260961.0, "length": 2311, "protein_name": "Proto-oncogene tyrosine-protein kinase ROS", "gene_name": "ROS1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ROS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase ROS; 2.7.10.1; Proto-oncogene c-Ros-1; Proto-oncogene c-Ros; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "11094073;11799110;1900358;3023892;3023956;3325887;8657124;9774423", "class_list": "", "function": "Orphan receptor tyrosine kinase (RTK) that may activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1, and PLCG2., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 37, "predicted_n_glycosites": 37, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 37, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019903 protein phosphatase binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0001558 regulation of cell growth;GO:0070372 regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08941-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09102-1", "uniprot_id": "PDIA1_CHICK", "mass": 57410.0, "length": 515, "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "P4HB; PDIA1; PDI", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein disulfide-isomerase; 5.3.4.1; Cellular thyroid hormone-binding protein; PDI; Prolyl 4-hydroxylase subunit beta; R-cognin; Retina cognin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2851999;2852147;7681992", "class_list": "", "function": "This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90969", "ec_number_list": "", "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09102-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09482-1", "uniprot_id": "ACHA4_CHICK", "mass": 70838.0, "length": 622, "protein_name": "Neuronal acetylcholine receptor subunit alpha-4", "gene_name": "CHRNA4", "organism": "Chicken", "refseq_name": "neuronal acetylcholine receptor subunit alpha-4 precursor", "refseq_ac": "NP_990145", "gene_names_uniprotkb": "CHRNA4", "gene_names_refseq": "CHRNA4; NACHRA4", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-4", "protein_names_refseq": "alpha-4 subunit, nicotinic acetylcholine receptor; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal acetylcholine receptor subunit alpha-4 precursor; neuronal acetylcholine receptor subunit alpha-4", "tax_id": 9031, "disease": "", "pathway": " (gga:395606)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2005979;3267226", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ250361.1, HAEK01001429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ250361.1., [RefSeq]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system (By similarity). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (By similarity). Involved in the modulation of calcium-dependent signaling pathways, influences the release of neurotransmitters, including dopamine, glutamate and GABA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P09482-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09484-1", "uniprot_id": "ACHB2_CHICK", "mass": 56032.0, "length": 491, "protein_name": "Neuronal acetylcholine receptor subunit beta-2", "gene_name": "CHRNB2", "organism": "Chicken", "refseq_name": "neuronal acetylcholine receptor subunit beta-2 precursor", "refseq_ac": "NP_990144", "gene_names_uniprotkb": "CHRNB2", "gene_names_refseq": "CHRNB2; NACHRB2", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-2; N-alpha 1; Neuronal acetylcholine receptor non-alpha-1 chain", "protein_names_refseq": "N-alpha 1; beta-2 subunit, nicotinic acetylcholine receptor; cholinergic receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); neuronal acetylcholine receptor non-alpha-1 chain; neuronal acetylcholine receptor subunit beta-2 precursor; neuronal acetylcholine receptor subunit beta-2", "tax_id": 9031, "disease": "", "pathway": " (gga:395605); (R-GGA-629587); (R-GGA-629594); (R-GGA-629597)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "2005979;3267226;3272170", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X53092.1, LC389196.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000351.1. On Dec 9, 2006 this sequence version replaced XP_001236645.1., [RefSeq]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB2 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3, CHRNA4 and CHRNA6, as well as CHRNA5 and CHRNB3 as accesory subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007613 memory;GO:0008542 visual learning;GO:0035095 behavioral response to nicotine;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09484-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P09572-1", "uniprot_id": "AT1A1_CHICK", "mass": 112231.0, "length": 1021, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-1", "gene_name": "ATP1A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATP1A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-1; 7.2.2.13; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396530)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2831227", "class_list": "", "function": "Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.2.2.13", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0042383 sarcolemma;GO:0005890 sodium:potassium-exchanging ATPase complex;GO:1990794 basolateral part of cell", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09572-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C1H5-1", "uniprot_id": "H2B7_CHICK", "mass": 13964.0, "length": 126, "protein_name": "Histone H2B 7", "gene_name": "H2B-VII", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H2B-VII", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H2B 7; H2B VII", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:107053803); (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-3214847); (R-GGA-427413); (R-GGA-5250924); (R-GGA-5689880); (R-GGA-5693565); (R-GGA-5693571); (R-GGA-5693607); (R-GGA-606279); (R-GGA-68616); (R-GGA-69473); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 27, "publication_count": 9, "publication_id_list": "12757711;12865423;12876341;15299701;1946434;2016071;2713375;3822819;8804862", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02279", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0C1H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DJH7-1", "uniprot_id": "CENPX_CHICK", "mass": 9257.0, "length": 80, "protein_name": "Centromere protein X", "gene_name": "CENPX", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CENPX; STRA13", "gene_names_refseq": "", "protein_names_uniprotkb": "Centromere protein X; CENP-X", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "12445392;19620631;22304917", "class_list": "", "function": "DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (By similarity). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631, PubMed:22304917). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0071821 FANCM-MHF complex;GO:0000776 kinetochore", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0051382 kinetochore assembly;GO:0006281 DNA repair;GO:0051301 cell division;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0DJH7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0DMQ6-1", "uniprot_id": "DHSO_CHICK", "mass": 38144.0, "length": 355, "protein_name": "Sorbitol dehydrogenase", "gene_name": "SORD", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SORD", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorbitol dehydrogenase; 1.1.1.-; Polyol dehydrogenase; SDH", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15592404;15649778", "class_list": "", "function": "Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) as substrate, leading to the C2-oxidized product D-fructose (PubMed:15649778). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051287 NAD binding;GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031514 motile cilium;GO:0031966 mitochondrial membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006061 sorbitol biosynthetic process;GO:0046370 fructose biosynthetic process;GO:0006062 sorbitol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0DMQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10039-1", "uniprot_id": "TENA_CHICK", "mass": 198859.0, "length": 1808, "protein_name": "Tenascin", "gene_name": "TNC", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TNC", "gene_names_refseq": "", "protein_names_uniprotkb": "Tenascin; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; TN-C; TN; Tenascin-C", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "11069908;2451243;2460335;2478295;9049254", "class_list": "", "function": "Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6., [UniProtKB]", "predicted_glycosites": 18, "predicted_n_glycosites": 17, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "O73584;O73585;P13132", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0030155 regulation of cell adhesion;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10184-1", "uniprot_id": "IOV7_CHICK", "mass": 57005.0, "length": 517, "protein_name": "Ovoinhibitor", "gene_name": "SPINK5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SPINK5; OIH", "gene_names_refseq": "", "protein_names_uniprotkb": "Ovoinhibitor; OI; OvoI; Serine protease inhibitor Kazal-type 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:416235)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11572089;13944692;14519973;14609095;15252730;15265086;15592404;22010862;23122126;25436390;3025257;3571241;6838526;6904299;8973172", "class_list": "", "function": "Serine protease inhibitor involved in antimicrobial egg defense preventing contamination of table eggs (non-fertilized eggs) and protecting the chick embryo (fertilized eggs) (Probable). Inhibits trypsin, chymotrypsin, elastase, subtilisin and a proteinase of fungus Aspergillus oryzae (PubMed:13944692, PubMed:14519973, PubMed:14609095, PubMed:22010862, PubMed:6838526, PubMed:6904299). Inhibits calcium-activated potassium channels KCNMA1 (bovine) and slo (Drosophila) (PubMed:8973172). Has antibacterial activity against B.thuringiensis LMSA 3.06.004, but not against S.aureus CIP 103 811, P.aeruginosa PAO1, B.cereus ATCC6464 or B.subtilis ATCC 6633 (PubMed:22010862)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q2UJ85;F1NMN2;Q6XLT0", "ec_number_list": "", "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity;GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045071 negative regulation of viral genome replication;GO:0051412 response to corticosterone", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P10184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P10360-1", "uniprot_id": "P53_CHICK", "mass": 40169.0, "length": 367, "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "organism": "Chicken", "refseq_name": "cellular tumor antigen p53", "refseq_ac": "NP_990595", "gene_names_uniprotkb": "TP53", "gene_names_refseq": "TP53", "protein_names_uniprotkb": "Cellular tumor antigen p53; Tumor suppressor p53", "protein_names_refseq": "cellular tumor antigen p53; tumor suppressor p53", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 9, "publication_id_list": "14990790;15723564;16813656;16820712;24068480;29511169;29750782;3060861;31021056", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X13057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X13057.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors., [RefSeq, PubMed]; An initial down-regulation of p53 allowed the SC-2 cells to bypass senescence. The inactivation of p53, and consequently p21WAF1, likely contributed to the SC-2 cells becoming a fully immortal cell line. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)., [UniProtKB]; Nine genes previously unknown to be involved in regulating p53 activity were identified. Ectopic expression of these basic helix-loop-helix transcription factors activated p53 and induced apoptosis., [RefSeq, PubMed]; Protein p53 occurs at key stages of development: in the esophagus during the remodeling of esophageal glands, in the proventriculus during the differentiation of the epithelium of the mucosa and in the gizzard during the formation of tubular glands., [RefSeq, PubMed]; Results suggest that extensive deletions are efficient mechanisms of TP53 inactivation, occurring as early events during the immortalization of v-src-transformed chicken cells., [RefSeq, PubMed]; Results suggest that the short form of p53 could play a role in the initiation of apoptosis induced by the chemotherapeutic compound, and that the regulation of its expression may be important for the maintenance of transformation status., [RefSeq, PubMed]; SESN1 regulate p53 by a feedback mechanism which is indispensable for myoblast proliferation and apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; TrkC tumor suppressor activity requires Hey1 and p53. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990841 promoter-specific chromatin binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051262 protein tetramerization;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P10360-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11029-1", "uniprot_id": "ACAC_CHICK", "mass": 262720.0, "length": 2324, "protein_name": "Acetyl-CoA carboxylase", "gene_name": "ACAC", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ACAC", "gene_names_refseq": "", "protein_names_uniprotkb": "Acetyl-CoA carboxylase; 6.4.1.2; ACC", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396504)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2879745;2893793", "class_list": "", "function": "Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.4.14;6.4.1.2", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity;GO:0004075 biotin carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0006633 fatty acid biosynthetic process;GO:2001295 malonyl-CoA biosynthetic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0097066 response to thyroid hormone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P11029-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11501-1", "uniprot_id": "HS90A_CHICK", "mass": 84059.0, "length": 728, "protein_name": "Heat shock protein HSP 90-alpha", "gene_name": "HSP90AA1", "organism": "Chicken", "refseq_name": "heat shock protein HSP 90-alpha", "refseq_ac": "NP_001103255", "gene_names_uniprotkb": "HSP90AA1; HSPCA", "gene_names_refseq": "HSP90AA1; HSP90; Hsp90alpha; cHsp90", "protein_names_uniprotkb": "Heat shock protein HSP 90-alpha", "protein_names_refseq": "heat shock 90 kDa protein; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein HSP 90-alpha; heat shock protein HSP90 alpha; hsp 90a", "tax_id": 9031, "disease": "", "pathway": " (gga:423463)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2762125;2923621;31707685", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CO635775.1, HAEK01013461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000215.1. On Dec 15, 2021 this sequence version replaced NP_001103255.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Genetic polymorphisms in part of intron 7 and exon 8 of HSP90AA1 gene and its association with heat tolerance traits in two exotic layer chicken strains., [RefSeq, PubMed]; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from Hsp90 which acquires an open conformation for the next cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030911 TPR domain binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0009409 response to cold;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0034605 cellular response to heat;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11602-1", "uniprot_id": "LIPL_CHICK", "mass": 55132.0, "length": 490, "protein_name": "Lipoprotein lipase", "gene_name": "LPL", "organism": "Chicken", "refseq_name": "lipoprotein lipase precursor", "refseq_ac": "NP_990613", "gene_names_uniprotkb": "LPL", "gene_names_refseq": "LPL", "protein_names_uniprotkb": "Lipoprotein lipase; 3.1.1.32; 3.1.1.34; LPL; Phospholipase A1", "protein_names_refseq": "adipose lipoprotein lipase; lipoprotein lipase precursor; phospholipase A1; triacylglycerol lipase", "tax_id": 9031, "disease": "", "pathway": " (gga:396219); (R-GGA-8963889)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16780787;1730055;19818411;1985932;25867349;2719965;9643364", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267661.17913.1, SRR13267654.145190.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000095.1. On Aug 30, 2004 this sequence version replaced XP_444663.1., [RefSeq]; Authors...analyzed polymorphisms in the ADSL and LPL genes using the high-resolution melting curve method. Publication Status: Online-Only, [RefSeq, PubMed]; Key enzyme in triglyceride metabolism (By similarity). Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (By similarity). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (By similarity). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (By similarity). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (By similarity)., [UniProtKB, UniProtKB]; LPL was characterized biochemically and by molecular cloning., [RefSeq, PubMed]; Studies identify HTGL, EL, Lipase H, and CEL in a pre-mammalian species and reveals novel details about specific features of the expression of these important molecules in lipid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.32;3.1.1.3;3.4.21.75;3.1.1.23;3.1.1.79;3.1.1.4;3.1.1.5;3.1.1.116;3.1.1.-;3.1.1.6;3.1.1.34", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0042803 protein homodimerization activity;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:0006631 fatty acid metabolic process;GO:0045600 positive regulation of fat cell differentiation;GO:0006633 fatty acid biosynthetic process;GO:0032722 positive regulation of chemokine production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11602-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11799-1", "uniprot_id": "MYLK_CHICK", "mass": 210446.0, "length": 1906, "protein_name": "Myosin light chain kinase, smooth muscle", "gene_name": "Mylk", "organism": "Chicken", "refseq_name": "myosin light chain kinase, smooth muscle isoform X2", "refseq_ac": "XP_046777166", "gene_names_uniprotkb": "Mylk", "gene_names_refseq": "KRP; MLCK; MYLK", "protein_names_uniprotkb": "Myosin light chain kinase, smooth muscle; 2.7.11.18; MLCK; Telokin", "protein_names_refseq": "myosin light chain kinase, smooth muscle isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 10, "publication_id_list": "10194305;12176732;1373815;1444462;2202734;2315320;3030394;7589469;9283094;9706877", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052579.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P19038;Q549S2", "ec_number_list": "2.7.11.18", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004687 myosin light chain kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0001725 stress fiber;GO:0032154 cleavage furrow", "go_biological_process": "GO:0003007 heart morphogenesis;GO:0055013 cardiac muscle cell development;GO:0045989 positive regulation of striated muscle contraction;GO:0014820 tonic smooth muscle contraction;GO:0060298 positive regulation of sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11799-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11939-1", "uniprot_id": "FOS_CHICK", "mass": 39005.0, "length": 367, "protein_name": "Protein c-Fos", "gene_name": "FOS", "organism": "Chicken", "refseq_name": "protein c-Fos", "refseq_ac": "NP_990839", "gene_names_uniprotkb": "FOS", "gene_names_refseq": "FOS", "protein_names_uniprotkb": "Protein c-Fos; Cellular oncogene fos; Transcription factor AP-1 subunit c-Fos", "protein_names_refseq": "c-fos proto-oncogene; cellular oncogene fos; protein c-Fos; proto-oncogene c-Fos; proto-oncogene protein c-fos; transcription factor AP-1 subunit c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:396512); (R-GGA-2559580); (R-GGA-2871796); (R-GGA-450341); (R-GGA-9018519)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "19217933;19756549;20170693;25005477;25710076;32350337;3316710;3330781;7935473", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M37000.1, Y00659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M37000.1., [RefSeq]; Dimeric combinations of MafB, cFos and cJun in developing chick limb buds control the number of apoptotic cells., [RefSeq, PubMed]; Inhibition of histone deacetylases in the chick brain up-regulates the expression of c-Fos and ZENK transcription factors and facilitates establishment of long-term memory., [RefSeq, PubMed]; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity)., [UniProtKB]; Results suggest that the learning-related increase in Fos protein production, which occurs in identifiable neuronal sub-populations in the intermediate and medial mesopallium, reflects events that make an early contribution to learning and/or memory, [RefSeq, PubMed]; The effect of monocular occlusion on hippocampal c-Fos expression in domestic chicks (Gallus gallus). Publication Status: Online-Only, [RefSeq, PubMed]; The expression of c-fos in the optokinetic nuclei is linked to near peak firing rates and the novelty and duration of the visual signals, supporting the assumption that expression is related to stimulus contexts leading to neuronal plastic changes., [RefSeq, PubMed]; This study demonistereated that c-fos gene expression accompanying filial imprinting in the newly hatched chick brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0060395 SMAD protein signal transduction;GO:0034614 cellular response to reactive oxygen species;GO:1902895 positive regulation of miRNA transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P11939-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12105-1", "uniprot_id": "CO3A1_CHICK", "mass": 121249.0, "length": 1262, "protein_name": "Collagen alpha-1(III) chain", "gene_name": "COL3A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "COL3A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(III) chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "6298201;6547770;6856474;8206952", "class_list": "", "function": "Collagen type III occurs in most soft connective tissues along with type I collagen., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P79758;P79759;Q90790;Q90791;Q90794;Q92029", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005586 collagen type III trimer", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0043588 skin development;GO:0048705 skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P12105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12276-1", "uniprot_id": "FAS_CHICK", "mass": 274782.0, "length": 2512, "protein_name": "Fatty acid synthase", "gene_name": "FASN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FASN; FAS", "gene_names_refseq": "", "protein_names_uniprotkb": "Fatty acid synthase; 2.3.1.85", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 14, "publication_id_list": "1939144;2648999;2681189;2734291;2751995;2842766;2917973;3182791;3207709;3207710;6361031;6654913;6654914;7944406", "class_list": "", "function": "Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.39;1.1.1.100;1.3.1.39;2.3.1.38;2.3.1.41;2.3.1.85;3.1.2.14;4.2.1.59", "go_molecular_function": "GO:0031177 phosphopantetheine binding;GO:0003697 single-stranded DNA binding;GO:0004312 fatty acid synthase activity;GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity;GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032100 positive regulation of appetite;GO:0006633 fatty acid biosynthetic process;GO:0006089 lactate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P12276-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P12957-1", "uniprot_id": "CALD1_CHICK", "mass": 88747.0, "length": 771, "protein_name": "Caldesmon", "gene_name": "CALD1", "organism": "Chicken", "refseq_name": "caldesmon isoform X4", "refseq_ac": "XP_046762264", "gene_names_uniprotkb": "CALD1; CAD", "gene_names_refseq": "CALD1", "protein_names_uniprotkb": "Caldesmon; CDM", "protein_names_refseq": "caldesmon isoform X4", "tax_id": 9031, "disease": "", "pathway": " (gga:373965); (R-GGA-445355)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10559276;1824698;1939059;1939602;2730665;2760048;2803315;3401222;8002994;8250919", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052573.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q03698;Q90756;Q90761;Q92018;Q99230", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0017022 myosin binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0001725 stress fiber;GO:0030016 myofibril", "go_biological_process": "GO:1903611 negative regulation of calcium-dependent ATPase activity;GO:0006936 muscle contraction;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P12957-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13387-1", "uniprot_id": "EGFR_CHICK", "mass": 77427.0, "length": 703, "protein_name": "Epidermal growth factor receptor", "gene_name": "EGFR", "organism": "Chicken", "refseq_name": "epidermal growth factor receptor precursor", "refseq_ac": "NP_990828", "gene_names_uniprotkb": "EGFR", "gene_names_refseq": "EGFR; c-erbB", "protein_names_uniprotkb": "Epidermal growth factor receptor; 2.7.10.1; CER", "protein_names_refseq": "CER; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); epidermal growth factor receptor precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396494)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22230616;23901748;28768863;3260329", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.238291.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On Oct 13, 2007 this sequence version replaced NP_990828.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data describe the mechanisms of oncogenesis induced in chickens by the myeloblastosis-associated virus 2 retrovirus; analyses identified HRAS, EGFR, MET, and RON as insertionally mutagenized driver genes and characterized the mechanisms of their tumorigenic activation Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that a conserved mechanism involving EGFR signaling governs proliferation of auditory supporting cells in birds and mammals and may represent a target for future hair cell regeneration strategies., [RefSeq, PubMed]; Epidermal growth factor receptor (EGFR) expression was significantly down-regulated after Marek's disease virus infection. The methylation level of the EGFR promoter was significantly increased at 21 days postinfection., [RefSeq, PubMed]; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:3260329). Known ligands include EGF and TGFA/TGF-alpha (PubMed:3260329). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (By similarity). May also activate the NF-kappa-B signaling cascade (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007611 learning or memory;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0071364 cellular response to epidermal growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13387-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13538-1", "uniprot_id": "MYSS_CHICK", "mass": 223145.0, "length": 1939, "protein_name": "Myosin heavy chain, skeletal muscle, adult", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin heavy chain, skeletal muscle, adult", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:427788)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "1939027;1939028;1939029;1939030;2610940;2713098;2775482;3034534;3467365;8316857;9358064", "class_list": "", "function": "Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O13228", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016460 myosin II complex", "go_biological_process": "GO:0006936 muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P13538-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13585-1", "uniprot_id": "AT2A1_CHICK", "mass": 109023.0, "length": 994, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "gene_name": "ATP2A1", "organism": "Chicken", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "refseq_ac": "NP_990850", "gene_names_uniprotkb": "ATP2A1", "gene_names_refseq": "ATP2A1; ATP2B3", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; 7.2.2.10; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; SERCA1; SR Ca(2+)-ATPase 1", "protein_names_refseq": "ATPase plasma membrane Ca2+ transporting 3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1; SERCA1; SR Ca(2+)-ATPase 1; calcium pump 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15924428;2526293", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M26064.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M26064.1., [RefSeq]; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction., [UniProtKB, UniProtKB]; Specific arrangements of Ca2+ ATPase headpiece domains shown in crystal structures are required to trigger displacement of transmembrane segments during the enzyme cycle in solution, allowing long range linkage of catalytic and Ca2+ binding functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.2.2.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0031674 I band", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0045988 negative regulation of striated muscle contraction;GO:0006942 regulation of striated muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P13585-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13863-1", "uniprot_id": "CDK1_CHICK", "mass": 34688.0, "length": 303, "protein_name": "Cyclin-dependent kinase 1", "gene_name": "CDK1", "organism": "Chicken", "refseq_name": "cyclin-dependent kinase 1", "refseq_ac": "NP_990645", "gene_names_uniprotkb": "CDK1; CDC2", "gene_names_refseq": "CDC2; CDK1", "protein_names_uniprotkb": "Cyclin-dependent kinase 1; 2.7.11.22; 2.7.11.23; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase", "protein_names_refseq": "cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; cyclin-dependent kinase 1; p34 protein kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:396252); (R-GGA-265976); (R-GGA-351451)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10449415;10938124;11376695;14580352;15066121;17349954;17575048;17928296;1846803;2188731;23301080;23741412;2684635;27603133;30135207", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X16881.1, HAEK01057001.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000227.1. On Sep 23, 2021 this sequence version replaced NP_990645.1., [RefSeq]; P17 suppresses both CDK1 and Plk1functions, disrupts vimentin phosphorylation, causes G2/M cell cycle arrest and thus benefits virus replication. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:2188731). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (By similarity). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (By similarity). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (PubMed:2188731)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0034605 cellular response to heat;GO:0042752 regulation of circadian rhythm;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P13863-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P13944-1", "uniprot_id": "COCA1_CHICK", "mass": 340582.0, "length": 3124, "protein_name": "Collagen alpha-1(XII) chain", "gene_name": "COL12A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "COL12A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(XII) chain; Fibrochimerin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "1420368;1918137;2584192;3476925;7642694", "class_list": "", "function": "Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix., [UniProtKB]", "predicted_glycosites": 19, "predicted_n_glycosites": 10, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "Q04509", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005614 interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0035987 endodermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13944-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14105-1", "uniprot_id": "MYH9_CHICK", "mass": 226503.0, "length": 1959, "protein_name": "Myosin-9", "gene_name": "MYH9", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYH9", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-9; Cellular myosin heavy chain, type A; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; NMMHC II-a; NMMHC-A; NMMHC-IIA; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396469)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1512291;2806244;2813355", "class_list": "", "function": "Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TNS8", "ec_number_list": "", "go_molecular_function": "GO:0005178 integrin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0031034 myosin filament assembly;GO:0001525 angiogenesis;GO:0006509 membrane protein ectodomain proteolysis;GO:0015031 protein transport;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P14105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14731-1", "uniprot_id": "LMNB1_CHICK", "mass": 66530.0, "length": 584, "protein_name": "Lamin-B1", "gene_name": "LMNB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LMNB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lamin-B1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396223)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2188731;2795656", "class_list": "", "function": "Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:2188731). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin (By similarity). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005882 intermediate filament;GO:0016363 nuclear matrix;GO:0005652 nuclear lamina", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0006998 nuclear envelope organization;GO:0031507 heterochromatin formation;GO:0007097 nuclear migration;GO:0051664 nuclear pore localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P14731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14732-1", "uniprot_id": "LMNB2_CHICK", "mass": 67941.0, "length": 600, "protein_name": "Lamin-B2", "gene_name": "LMNB2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LMNB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Lamin-B2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396222)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18612635;2188731;2477550;8449977", "class_list": "", "function": "Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:2188731). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin (By similarity). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005882 intermediate filament;GO:0016363 nuclear matrix;GO:0005652 nuclear lamina", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0006998 nuclear envelope organization;GO:0031507 heterochromatin formation;GO:0007097 nuclear migration;GO:0051664 nuclear pore localization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14732-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14791-1", "uniprot_id": "HMOX1_CHICK", "mass": 33509.0, "length": 296, "protein_name": "Heme oxygenase 1", "gene_name": "HMOX1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HMOX1", "gene_names_refseq": "", "protein_names_uniprotkb": "Heme oxygenase 1; 1.14.14.18; HO-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396287)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1996964;2158889", "class_list": "", "function": "Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:1996964, PubMed:2158889). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.18", "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042167 heme catabolic process;GO:0006788 heme oxidation;GO:0110076 negative regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P14791-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16039-1", "uniprot_id": "NPM_CHICK", "mass": 32632.0, "length": 294, "protein_name": "Nucleophosmin", "gene_name": "NPM1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NPM1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396203)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2114180;2320420;2914325", "class_list": "", "function": "Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P16039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16047-1", "uniprot_id": "TGFB3_CHICK", "mass": 47078.0, "length": 412, "protein_name": "Transforming growth factor beta-3 proprotein", "gene_name": "TGFB3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TGFB3", "gene_names_refseq": "", "protein_names_uniprotkb": "Transforming growth factor beta-3 proprotein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396438)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1406706;1840616;3211158;7865129", "class_list": "", "function": "Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively., [UniProtKB, UniProtKB, UniProtKB]; Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0050431 transforming growth factor beta binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007399 nervous system development;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P16047-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16075-1", "uniprot_id": "MYOD1_CHICK", "mass": 32991.0, "length": 298, "protein_name": "Myoblast determination protein 1 homolog", "gene_name": "MYOD1", "organism": "Chicken", "refseq_name": "myoblast determination protein 1 homolog", "refseq_ac": "NP_989545", "gene_names_uniprotkb": "MYOD1; CMD1; MYOD", "gene_names_refseq": "MYOD1", "protein_names_uniprotkb": "Myoblast determination protein 1 homolog; MYOD1 homolog", "protein_names_refseq": "MYOD1 homolog; myoblast determination protein 1 homolog; myogenic factor 1; myogenic factor 3", "tax_id": 9031, "disease": "", "pathway": " (gga:374048)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14706073;14981095;15661645;17698608;19778533;19833199;2777078;8035824", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X16189.1, FJ977569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Sep 23, 2021 this sequence version replaced NP_989545.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity)., [UniProtKB]; MyoD expression is regulated by Hoxa-11 and Hoxa-13 in limb muscle precursors, [RefSeq, PubMed]; MyoD-positive epiblast cells are stasbly committed to the skeletal muscle cell lineage., [RefSeq, PubMed]; NeuroM and MyoD are present in separate subpopulations of cells in the pregastrulating epiblast; epiblast cells with NeuroM are more dependent on exogenous factors to differentiate than those with MyoD, [RefSeq, PubMed]; Study demonstrates that MyoD expressing cells serve as a Noggin delivery system to regulate the morphogenesis of the lens and optic cup., [RefSeq, PubMed]; These results demonstrate that MyoD-positive epiblast cells recruit pluripotent cells to the skeletal muscle lineage through a mechanism thatinvolves blocking the BMP signaling pathway [MyoD]., [RefSeq, PubMed]; Vgl-2 acts downstream of MyoD activation and is associated with the differentiation step in embryonic skeletal myogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90916", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P16075-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16236-1", "uniprot_id": "REL_CHICK", "mass": 66847.0, "length": 598, "protein_name": "Proto-oncogene c-Rel", "gene_name": "REL", "organism": "Chicken", "refseq_name": "proto-oncogene c-Rel", "refseq_ac": "NP_001161198", "gene_names_uniprotkb": "REL", "gene_names_refseq": "REL; p68-c-rel", "protein_names_uniprotkb": "Proto-oncogene c-Rel; p68", "protein_names_refseq": "C-Rel protein; C-Rel proto-oncogene protein; p68; proto-oncogene c-Rel; v-rel avian reticuloendotheliosis viral oncogene homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:396500)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11587641;14961076;16287166;2167440;2179815;2555689;7916720", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.315279.1, SRR13267649.271386.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000059.1. On Sep 23, 2021 this sequence version replaced NP_001161198.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Alterations between v-Rel and c-Rel locate within the Rel homology region (RHR) of the family that might confer functional differences., [RefSeq, PubMed]; Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034097 response to cytokine;GO:0007249 canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16236-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P16580-1", "uniprot_id": "GLNA_CHICK", "mass": 42146.0, "length": 373, "protein_name": "Glutamine synthetase", "gene_name": "GLUL", "organism": "Chicken", "refseq_name": "glutamine synthetase", "refseq_ac": "NP_990824", "gene_names_uniprotkb": "GLUL; GLNS", "gene_names_refseq": "GLUL; p42", "protein_names_uniprotkb": "Glutamine synthetase; 4.1.1.15; 6.3.1.2; GS; Glutamate decarboxylase; Glutamate--ammonia ligase; p42", "protein_names_refseq": "GS; glutamate decarboxylase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase (glutamine synthetase); glutamine synthetase", "tax_id": 9031, "disease": "", "pathway": " (gga:396489)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12965260;1356223;19895308;20053634;2572512;28875233;4401992", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M29076.1, S45408.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000237.1. On Sep 23, 2021 this sequence version replaced NP_990824.1., [RefSeq]; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:19895308). When expressed in liver, it may be involved in detoxifying intramitochondrially generated ammonia (PubMed:4401992). Also acts as glutamate decarboxylase by catalyzing the production of 4-aminobutanoate (gamma-aminobutyric acid, GABA) in a pyridoxal phosphate-independent manner (PubMed:19895308)., [UniProtKB, PubMed, PubMed]; The N-terminus of GS, which constitutes a 'weak' mitochondrial targeting signal (MTS), is sufficient to direct a chimeric protein to the mitochondria in hepatocytes and to the cytoplasm in astrocytes, [RefSeq, PubMed]; These results demonstrate a novel mode of glutamate-dependent glutamine synthetase regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0FZC2", "ec_number_list": "6.3.1.2;4.1.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004356 glutamine synthetase activity;GO:0004351 glutamate decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006542 glutamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16580-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17678-1", "uniprot_id": "GATA1_CHICK", "mass": 31417.0, "length": 304, "protein_name": "Erythroid transcription factor", "gene_name": "GATA1", "organism": "Chicken", "refseq_name": "erythroid transcription factor", "refseq_ac": "NP_990795", "gene_names_uniprotkb": "GATA1; ERYF1", "gene_names_refseq": "ERYF1; GATA-1; GATA1; NF-E1a", "protein_names_uniprotkb": "Erythroid transcription factor; Eryf1; GATA-1; GATA-binding factor 1; NF-E1 DNA-binding protein; NF-E1a", "protein_names_refseq": "GATA-binding factor 1; NF-E1 DNA-binding protein; erythroid transcription factor; erythroid-specific transcription factor eryf1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "15033488;17984219;18924232;2249770;2776214;8332909;9303001;9859997", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M26209.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M26209.1., [RefSeq]; Analysis of the interaction between the transcription factor Gata-1 zinc finger and DNA, [RefSeq, PubMed]; Erythropoiesis in the yolk sac is accompanied by the expression of transcriptional regulators gata1, scl, and lmo2., [RefSeq, PubMed]; Findings reveal that GATA-1 plays a major role in defining both the chromatin structure and the activity of the alpha-globin 3' enhancer, [RefSeq, PubMed]; Transcriptional activator or repressor which serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045165 cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P17678-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17920-1", "uniprot_id": "MYOG_CHICK", "mass": 25854.0, "length": 227, "protein_name": "Myogenin", "gene_name": "MYOG", "organism": "Chicken", "refseq_name": "myogenin", "refseq_ac": "NP_989515", "gene_names_uniprotkb": "MYOG", "gene_names_refseq": "MYOG", "protein_names_uniprotkb": "Myogenin; Myogenic factor", "protein_names_refseq": "myogenic factor; myogenin (myogenic factor 4); myogenin", "tax_id": 9031, "disease": "", "pathway": " (gga:374004)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17855259;2168405;23054870;24397509;25098599;30550926", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01007749.1, D90157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1., [RefSeq]; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity)., [UniProtKB]; Data suggest that selenium (Se; a dietary factor) promotes differentiation of embryonic myoblasts; up-regulation of selenoprotein W (SelW) and up-regulation of myogenic regulatory factors (myogenin/MYF4; MRF4; MRF5) upon Se treatment are correlated., [RefSeq, PubMed]; Low daily feed intake did not alter the trend in myostatin (MSTN) mRNA expression levels in either line, but significantly changed the peak values. Myogenin (MYOG) mRNA expression varied by line and over time, with a delay in the Lean line., [RefSeq, PubMed]; MyoG gene is the major gene affect-ing the muscle fiber traits of chicken, and the mutation could be used as the molecular genetic marker to select the chickens for Meat Quality traits., [RefSeq, PubMed]; Single nucleotide polymorphisms of the MyoG and Myf5 genes had certain effects on growth traits of the Jinghai yellow chicken., [RefSeq, PubMed]; Thermal stress for 6h down-regulate the mRNA expression of liver Myogenin, concomitantly with an increase in the expression of HSP90 gene in both broiler strains., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0014891 striated muscle atrophy;GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P17920-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P17924-1", "uniprot_id": "NFIB_CHICK", "mass": 62623.0, "length": 560, "protein_name": "Nuclear factor 1 B-type", "gene_name": "NFIB", "organism": "Chicken", "refseq_name": "nuclear factor 1 B-type isoform 1", "refseq_ac": "NP_990603", "gene_names_uniprotkb": "NFIB; NFI-B", "gene_names_refseq": "NFIB", "protein_names_uniprotkb": "Nuclear factor 1 B-type; CCAAT-box-binding transcription factor; CTF; NF-I/B; NF1-B; NFI-B; Nuclear factor 1/B; Nuclear factor I/B; TGGCA-binding protein", "protein_names_refseq": "CCAAT-box binding transcription factor; CTF; NF-I/B; NF1-B; NFI-B; TGGCA-binding protein; nuclear factor 1 B-type isoform 1; nuclear factor 1 B-type; nuclear factor 1/B", "tax_id": 9031, "disease": "", "pathway": " (gga:396209)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2339052", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X51485.1, SRR13267662.22122.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000092.1., [RefSeq]; Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17925", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0044300 cerebellar mossy fiber", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006260 DNA replication;GO:0002062 chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17924-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18254-1", "uniprot_id": "IGF1_CHICK", "mass": 17267.0, "length": 153, "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "organism": "Chicken", "refseq_name": "insulin-like growth factor 1 preproprotein", "refseq_ac": "NP_001004384", "gene_names_uniprotkb": "IGF1; IGF-1", "gene_names_refseq": "IGF-1; IGF-I; IGF1", "protein_names_uniprotkb": "Insulin-like growth factor 1; IGF-I; Insulin-like growth factor I; Somatomedin", "protein_names_refseq": "insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1 preproprotein; insulin-like growth factor I; somatomedin", "tax_id": 9031, "disease": "", "pathway": " (gga:418090)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "2033062;2272467;26059224;2628728;26944971;27128575;28594135;35141787", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FJ977570.1, HAEK01157508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FJ977570.1 and HAEK01157508.1. On Sep 17, 2004 this sequence version replaced XP_416323.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Beneficial impact of dietary methyl methionine sulfonium chloride and/or L-carnitine supplementation on growth performance, feed efficiency, and serum biochemical parameters in broiler chicken: role of IGF-1 and MSTN genes. Publication Status: Online-Only, [RefSeq, PubMed]; IGF1 and IGF2 might separately be more important for muscle and liver growth in chick embryonic development. Variation of IGFs expression during the incubation might be concerned with the methylation of gene promoter., [RefSeq, PubMed]; It is a protein synthesis-related factor., [RefSeq, PubMed]; The coding region of the IGF1 gene was polymorphic, expressed differentially during the pre-hatch and post-hatch periods, and haplogroups showed significant association with growth traits in chicken., [RefSeq, PubMed]; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling., [UniProtKB, UniProtKB]; These findings demonstrated that MEL mediated the monochromatic light-induced secretion of IGF-1 in chicks' livers by Mel1c and that Mel1a may be involved in this process., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P18254-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18460-1", "uniprot_id": "FGFR3_CHICK", "mass": 89730.0, "length": 806, "protein_name": "Fibroblast growth factor receptor 3", "gene_name": "FGFR3", "organism": "Chicken", "refseq_name": "fibroblast growth factor receptor 3", "refseq_ac": "NP_990840", "gene_names_uniprotkb": "FGFR3; CEK2", "gene_names_refseq": "CEK2; FGFR3", "protein_names_uniprotkb": "Fibroblast growth factor receptor 3; 2.7.10.1; FGFR-3; Tyrosine kinase receptor CEK2", "protein_names_refseq": "FGFR-3; fibroblast growth factor receptor 3-IIIc; fibroblast growth factor receptor 3; tyrosine kinase (cek2); tyrosine kinase receptor CEK2", "tax_id": 9031, "disease": "", "pathway": " (gga:396515)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17552942;18339367;2165604", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Sep 11, 2008 this sequence version replaced NP_990840.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Essential roles for FGF/FGFR signaling in the elongation of Meckel's cartilage, development of osteogenic condensations and appositional growth of mandibular bones Erratum:[Orthod Craniofac Res. 2007 Nov;10(4):235. Velonis, D A [added]], [RefSeq, PubMed]; FGFR3 signaling is required for the elongation of Meckel's cartilage and during intramembranous ossification of mandibular bones., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process;GO:0010604 positive regulation of macromolecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18460-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18461-1", "uniprot_id": "FGFR2_CHICK", "mass": 92299.0, "length": 823, "protein_name": "Fibroblast growth factor receptor 2", "gene_name": "FGFR2", "organism": "Chicken", "refseq_name": "fibroblast growth factor receptor 2 precursor", "refseq_ac": "NP_990650", "gene_names_uniprotkb": "FGFR2; CEK3", "gene_names_refseq": "BEK; FGFR2; bFGFR; cek3; chicken-bek", "protein_names_uniprotkb": "Fibroblast growth factor receptor 2; 2.7.10.1; FGFR-2; Tyrosine kinase receptor CEK3", "protein_names_refseq": "FGFR-2; chicken tyrosine kinase (cek3); fibroblast growth factor receptor 2 precursor; receptor tyrosine kinase; tyrosine kinase receptor CEK3", "tax_id": 9031, "disease": "", "pathway": " (gga:396259)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15749079;16243462;16888091;2165604;30620790", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M35196.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000232.1. On Dec 14, 2020 this sequence version replaced NP_990650.1., [RefSeq]; Expression 1 and 5 days after exposure to wide-band noise with two increasing levels of acoustic energy, [RefSeq, PubMed]; FGF receptors are expressed only in epithelia of the embryonic digestive tract., [RefSeq, PubMed]; Inhibition of FGFR2 activity leads to ectopic blood formation and down-regulation of endothelial markers, [RefSeq, PubMed]; The bent long bones in Bent bone dysplasia syndrome arise from disruptions in musculoskeletal integration and increased nuclear and nucleolar localization of FGFR2 plays a mechanistic role in the disease phenotype, [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1 (By similarity)., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18461-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18519-1", "uniprot_id": "TNR16_CHICK", "mass": 44654.0, "length": 416, "protein_name": "Tumor necrosis factor receptor superfamily member 16", "gene_name": "NGFR", "organism": "Chicken", "refseq_name": "tumor necrosis factor receptor superfamily member 16 precursor", "refseq_ac": "NP_001139605", "gene_names_uniprotkb": "NGFR; TNFRSF16", "gene_names_refseq": "NGFR; TNFRSF16", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD", "protein_names_refseq": "Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; NGF receptor; gp80-LNGFR; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); p75 ICD; tumor necrosis factor receptor superfamily member 16 precursor; tumor necrosis factor receptor superfamily member 16", "tax_id": 9031, "disease": "", "pathway": " (gga:425805)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16243462;17418844;21463686;2154393;2560385", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.127837.1, SRR13267652.10763.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03579563 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000364.1. On Nov 17, 2021 this sequence version replaced NP_001139605.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Data support the hypothesis that a fine-tuned interplay of ephrinA6 with p75(NTR) and TrkB is important for the guidance and branching of RGC axons., [RefSeq, PubMed]; Expression 1 and 5 days after exposure to wide-band noise with two increasing levels of acoustic energy, [RefSeq, PubMed]; Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (By similarity). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (By similarity). Necessary for the circadian oscillation of clock genes in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; NGF signaling plays a significant role in the shaping of neural tube in chick embryos through p75(NTR)-NGF receptor., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0043121 neurotrophin binding;GO:0015026 coreceptor activity;GO:0005035 death receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030426 growth cone;GO:0043197 dendritic spine;GO:0043204 perikaryon", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0007266 Rho protein signal transduction;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18519-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18861-1", "uniprot_id": "CXG1_CHICK", "mass": 45372.0, "length": 394, "protein_name": "Gap junction gamma-1 protein", "gene_name": "GJC1", "organism": "Chicken", "refseq_name": "gap junction gamma-1 protein", "refseq_ac": "NP_990834", "gene_names_uniprotkb": "GJC1; GJA7", "gene_names_refseq": "GJA7; GJC1; GJC3", "protein_names_uniprotkb": "Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein", "protein_names_refseq": "connexin-45; cx45; gap junction alpha-7 protein; gap junction gamma-1 protein; gap junction protein gamma 1; gap junction protein, alpha 7, 45kDa (connexin 45); gap junction protein, gamma 1, 45kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:396501); (R-GGA-112303); (R-GGA-190861)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2167316", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.261700.1, SRR13267653.8930.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000363.1. On Nov 5, 2021 this sequence version replaced XP_040509065.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0016264 gap junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18861-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18946-1", "uniprot_id": "CYB_CHICK", "mass": 42592.0, "length": 380, "protein_name": "Cytochrome b", "gene_name": "MT-CYB", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MT-CYB; COB; CYTB; MTCYB", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome b; Complex III subunit 3; Complex III subunit III; Cytochrome b-c1 complex subunit 3; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "20025846;21575592;22690928;2329578;8308906;9565029", "class_list": "", "function": "Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0022904 respiratory electron transport chain;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P19121-1", "uniprot_id": "ALBU_CHICK", "mass": 69918.0, "length": 615, "protein_name": "Albumin", "gene_name": "ALB", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ALB", "gene_names_refseq": "", "protein_names_uniprotkb": "Albumin; Alpha-livetin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "11488669;18950868;6187737;911327", "class_list": "", "function": "Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005504 fatty acid binding;GO:0015643 toxic substance binding;GO:0030170 pyridoxal phosphate binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex;GO:0060417 yolk", "go_biological_process": "GO:0031667 response to nutrient levels;GO:0009615 response to virus;GO:0033189 response to vitamin A;GO:0009267 cellular response to starvation;GO:0051902 negative regulation of mitochondrial depolarization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20111-1", "uniprot_id": "ACTN2_CHICK", "mass": 104275.0, "length": 897, "protein_name": "Alpha-actinin-2", "gene_name": "ACTN2", "organism": "Chicken", "refseq_name": "alpha-actinin-2", "refseq_ac": "NP_990654", "gene_names_uniprotkb": "ACTN2", "gene_names_refseq": "ACTN2", "protein_names_uniprotkb": "Alpha-actinin-2; Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein", "protein_names_refseq": "F-actin cross-linking protein; alpha-actinin skeletal muscle; alpha-actinin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:396263)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1483465;1720388;3197725", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X59247.1, SRR13267649.35206.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1., [RefSeq]; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90821", "ec_number_list": "", "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0030175 filopodium;GO:0030018 Z disc;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0030035 microspike assembly;GO:0055001 muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20111-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20136-1", "uniprot_id": "GSTM2_CHICK", "mass": 25893.0, "length": 220, "protein_name": "Glutathione S-transferase 2", "gene_name": "GSTM2", "organism": "Chicken", "refseq_name": "glutathione S-transferase 2", "refseq_ac": "NP_990421", "gene_names_uniprotkb": "GSTM2", "gene_names_refseq": "GSTM2", "protein_names_uniprotkb": "Glutathione S-transferase 2; 2.5.1.18; GST class-mu; GST-CL2; GSTM1-1", "protein_names_refseq": "GST class-mu; GST-CL2; GSTM1-1; glutathione S-transferase 2; glutathione S-transferases CL2", "tax_id": 9031, "disease": "", "pathway": " (gga:395976)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10903867;1954256;2337594;9571047", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X58248.1, BU123479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1., [RefSeq]; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity) (PubMed:10903867). Participates in the formation of novel hepoxilin regioisomers (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.2;2.5.1.18;1.20.4.2;1.8.5.1;5.3.99.2", "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20136-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21611-1", "uniprot_id": "B2MG_CHICK", "mass": 13042.0, "length": 119, "protein_name": "Beta-2-microglobulin", "gene_name": "B2M", "organism": "Chicken", "refseq_name": "beta-2-microglobulin precursor", "refseq_ac": "NP_001001750", "gene_names_uniprotkb": "B2M", "gene_names_refseq": "B2M; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03", "protein_names_uniprotkb": "Beta-2-microglobulin", "protein_names_refseq": "beta-2-microglobulin precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:414830); (R-GGA-1236974); (R-GGA-1236977); (R-GGA-198933); (R-GGA-6798695); (R-GGA-983170)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "1538136;16039723;16112197;18083574;18612635;2011126;23918553;25860507;8577748", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BM489804.1, HAEK01011145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000245.1. On Mar 13, 2018 this sequence version replaced NP_001001750.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system., [UniProtKB]; Five new BF2 groups and a new beta(2)m group exist in the three Chinese chicken lines, [RefSeq, PubMed]; The expression levels of Class I MHC and beta2m genes were upregulated during early Marek's disease viral infections in comparison to control cells, [RefSeq, PubMed]; The two-dimensional (2D) and three-dimensional (3D) structures of chicken major histocompatibility complex (MHC) class I protein (BF2 and beta2m)were elucidated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5W922", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0023026 MHC class II protein complex binding;GO:0005198 structural molecule activity;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0006955 immune response;GO:0007611 learning or memory;GO:0051289 protein homotetramerization;GO:1990000 amyloid fibril formation;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P21611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21760-1", "uniprot_id": "EXFAB_CHICK", "mass": 20201.0, "length": 178, "protein_name": "Extracellular fatty acid-binding protein", "gene_name": "EXFABP", "organism": "Chicken", "refseq_name": "extracellular fatty acid-binding protein precursor", "refseq_ac": "NP_990753", "gene_names_uniprotkb": "EXFABP", "gene_names_refseq": "EX-FABP; EXFABP; LCN15; LCN8; P20K", "protein_names_uniprotkb": "Extracellular fatty acid-binding protein; Ex-FABP; Protein Ch21; Quiescence-specific protein; p20K", "protein_names_refseq": "extracellular fatty acid-binding protein precursor; lipocalin 15; lipocalin 8; quiescence-specific protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396393)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11058755;14584054;1549365;1737754;21691711;22153502;2229062;2346493;2498647;25436390;8702740", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01016955.1, CF251600.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992648, SAMEA2812691 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000308.1. On Sep 23, 2021 this sequence version replaced NP_990753.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor., [UniProtKB]; The Ex-FABP gene could be a candidate locus or linked to a QTL that significantly affects fatty deposition and metabolism in chicken., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P21928;Q6E6M8;Q9PWN9", "ec_number_list": "", "go_molecular_function": "GO:0070538 oleic acid binding;GO:0005504 fatty acid binding;GO:0050544 arachidonate binding;GO:0070539 linoleic acid binding;GO:0070540 stearic acid binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0009792 embryo development ending in birth or egg hatching;GO:0003415 chondrocyte hypertrophy;GO:0006629 lipid metabolic process;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P21760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21804-1", "uniprot_id": "FGFR1_CHICK", "mass": 91577.0, "length": 819, "protein_name": "Fibroblast growth factor receptor 1", "gene_name": "FGFR1", "organism": "Chicken", "refseq_name": "fibroblast growth factor receptor 1 precursor", "refseq_ac": "NP_990841", "gene_names_uniprotkb": "FGFR1; CEK1", "gene_names_refseq": "CEK1; FGFR1; bFGF", "protein_names_uniprotkb": "Fibroblast growth factor receptor 1; 2.7.10.1; Basic fibroblast growth factor receptor 1; FGFR-1; Tyrosine kinase receptor CEK1; bFGF-R-1", "protein_names_refseq": "FGFR-1; bFGF-R-1; basic fibroblast growth factor receptor 1; cek1 protein; chicken embryo kinase 1; fibroblast growth factor receptor 1 precursor; fibroblast growth factor receptor 1-IIIc; tyrosine kinase receptor CEK1", "tax_id": 9031, "disease": "", "pathway": " (gga:396516)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15580623;15749079;20554758;2473471;2544996;31237331", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000332.1. On or before Oct 4, 2021 this sequence version replaced XP_015152848.2, NP_990841.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Anti-FGFR1 peptide antibodies decreased egg production of hens and growth performance of their progeny chicks probably by activating FGF-23 signaling and stimulating FGF-23 production., [RefSeq, PubMed]; BTEB1 activated the FGFR1 promoter via interaction with the Sp1-like binding site located at -59 bp within the FGFR1 promoter., [RefSeq, PubMed]; FGF receptors are expressed only in epithelia of the embryonic digestive tract., [RefSeq, PubMed]; FGFR1 promoter activity in skeletal muscle cells is repressed by E2F4., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0045597 positive regulation of cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0003347 epicardial cell to mesenchymal cell transition", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P21804-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21872-1", "uniprot_id": "PUR2_CHICK", "mass": 106544.0, "length": 1003, "protein_name": "Trifunctional purine biosynthetic protein adenosine-3", "gene_name": "GART", "organism": "Chicken", "refseq_name": "trifunctional purine biosynthetic protein adenosine-3", "refseq_ac": "NP_001001469", "gene_names_uniprotkb": "GART", "gene_names_refseq": "AIRS; GARS; GART-A; GART", "protein_names_uniprotkb": "Trifunctional purine biosynthetic protein adenosine-3; 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; Glycinamide ribonucleotide synthetase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide synthetase", "protein_names_refseq": "aminoimidazole ribonucleotide synthetase; trifunctional purine biosynthetic protein adenosine-3", "tax_id": 9031, "disease": "", "pathway": " (gga:395315); (R-GGA-419140)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11323713;17224163;2111814;2123487;2147474;4726295", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.61913.1, SRR13267661.20368.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000020.1. On or before Oct 3, 2021 this sequence version replaced XP_015154703.2, NP_001001469.1., [RefSeq]; Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.2.2;6.3.3.1;6.3.4.13", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004637 phosphoribosylamine-glycine ligase activity;GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity;GO:0004644 phosphoribosylglycinamide formyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0046084 adenine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P21872-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22328-1", "uniprot_id": "OPSD_CHICK", "mass": 39327.0, "length": 351, "protein_name": "Rhodopsin", "gene_name": "RHO", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RHO", "gene_names_refseq": "", "protein_names_uniprotkb": "Rhodopsin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:751791)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3195056", "class_list": "", "function": "Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G proteins. Subsequent receptor phosphorylation mediates displacement of the bound G protein alpha subunit by arrestin and terminates signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0001965 G-protein alpha-subunit binding;GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0097381 photoreceptor disc membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0070207 protein homotrimerization;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P22328-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22329-1", "uniprot_id": "OPSR_CHICK", "mass": 40326.0, "length": 362, "protein_name": "Red-sensitive opsin", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Red-sensitive opsin; Iodopsin; Red cone photoreceptor pigment", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396421)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2226824;2268324;2271641;7629014", "class_list": "", "function": "Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0031404 chloride ion binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0060342 photoreceptor inner segment membrane;GO:0005886 plasma membrane;GO:0044297 cell body;GO:0031982 vesicle;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0070207 protein homotrimerization;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P22329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P22770-1", "uniprot_id": "ACHA7_CHICK", "mass": 56947.0, "length": 502, "protein_name": "Neuronal acetylcholine receptor subunit alpha-7", "gene_name": "CHRNA7", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHRNA7", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-7; Nicotinic acetylcholine receptor subunit alpha-7; nAChR7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "1383829;1425587;1702646;1719423;2369519;3860855;8145738", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA7 is an homooligomeric neuronal acetylcholine receptor abundantly expressed in the central nervous system. Characterized by a fast desensitization and high calcium permeability (PubMed:1702646). Also expressed in non-neuronal cells such as immune cells like lymphocytes, monocytes and macrophages (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0015643 toxic substance binding;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0008284 positive regulation of cell population proliferation;GO:0035094 response to nicotine;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P22770-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23614-1", "uniprot_id": "BASP1_CHICK", "mass": 25438.0, "length": 244, "protein_name": "Brain acid soluble protein 1 homolog", "gene_name": "BASP1", "organism": "Chicken", "refseq_name": "brain acid soluble protein 1 homolog", "refseq_ac": "NP_989447", "gene_names_uniprotkb": "BASP1", "gene_names_refseq": "BASP1; CAP-23", "protein_names_uniprotkb": "Brain acid soluble protein 1 homolog; 23 kDa cortical cytoskeleton-associated protein; CAP-23", "protein_names_refseq": "23 kDa cortical cytoskeleton-associated protein; brain acid soluble protein 1 homolog23 kDa cortical cytoskeleton-associated protein; brain acid soluble protein 1 homolog; particle bound cytosolic protein CAP23", "tax_id": 9031, "disease": "", "pathway": " (gga:373905); (R-GGA-9035034)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19297618;2148567", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU132819.1, SRR13267657.24469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992453 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000040.1., [RefSeq]; Down-regulation of the BASP1 gene is a necessary event in myc-induced oncogenesis, defining the BASP1 protein as a potential tumor suppressor., [RefSeq, PubMed]; May play a specific role in the development of tissues., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8JHB7", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0030426 growth cone", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription;GO:0097435 supramolecular fiber organization;GO:0072112 podocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P23614-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P23825-1", "uniprot_id": "GATA3_CHICK", "mass": 48197.0, "length": 444, "protein_name": "GATA-binding factor 3", "gene_name": "GATA3", "organism": "Chicken", "refseq_name": "GATA-binding factor 3 isoform a", "refseq_ac": "NP_001008444", "gene_names_uniprotkb": "GATA3", "gene_names_refseq": "GATA3; cGATA-3", "protein_names_uniprotkb": "GATA-binding factor 3; GATA-3; Transcription factor NF-E1c", "protein_names_refseq": "GATA-3; GATA-binding factor 3 isoform a; GATA-binding factor 3; transcription factor NF-E1c", "tax_id": 9031, "disease": "", "pathway": " (gga:419106); (R-GGA-8939236); (R-GGA-9018519); (R-GGA-983231)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "15329349;19673002;19924793;2017177;2249770;29247144;7629014", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.52420.1, SRR13267649.161909.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000011.1. On or before Nov 3, 2021 this sequence version replaced XP_015148823.1, XP_417294.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Characterized the regulatory roles of two transcription factors, NFIA and GATA3, in articular cartilage differentiation, maintenance and the coordinated differentiation of articular and transient cartilage. Both NFIA and GATA3 block hypertrophic differentiation. Our results suggest that NFIA is not sufficient but necessary for articular cartilage differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Data establish Gata2 and Gata3 as essential members of the transcription factor network controlling sympathetic neuron development., [RefSeq, PubMed]; GATA3 impacts WNT signaling in this region of the sensory macula., [RefSeq, PubMed]; Our results suggest that Gata3 may be specifically involved in the differentiation of auditory ganglion neurons during embryogenesis., [RefSeq, PubMed]; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6LD66", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0042491 inner ear auditory receptor cell differentiation;GO:0032754 positive regulation of interleukin-5 production;GO:0035457 cellular response to interferon-alpha;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P23825-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24045-1", "uniprot_id": "GBRB4_CHICK", "mass": 56069.0, "length": 488, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-4", "gene_name": "GABRB4", "organism": "Chicken", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-4 isoform 1 precursor", "refseq_ac": "NP_001161175", "gene_names_uniprotkb": "GABRB4", "gene_names_refseq": "GABRB1; GABRB4; GABRQ", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-4; GABA(A) receptor subunit beta-4", "protein_names_refseq": "GABA(A) receptor subunit beta-4; GABA-A receptor, beta-4 subunit; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid (GABA) receptor, theta; gamma-aminobutyric acid receptor subunit beta-4 isoform 1 precursor; gamma-aminobutyric acid receptor subunit beta-4; gamma-aminobutyric acid type A receptor theta subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:396288); (R-GGA-977443)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1848280", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X56647.1, SRR13267649.113618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6LBM6", "ec_number_list": "", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P24045-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P24797-1", "uniprot_id": "AT1A2_CHICK", "mass": 112051.0, "length": 1017, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-2", "gene_name": "ATP1A2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATP1A2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-2; 7.2.2.13; Na(+)/K(+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2171348", "class_list": "", "function": "Catalytic subunit of the Na(+)/K(+)-ATPase that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle (By similarity). It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.2.2.13", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0042995 cell projection;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0001504 neurotransmitter uptake;GO:0006942 regulation of striated muscle contraction;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P24797-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26007-1", "uniprot_id": "ITA6_CHICK", "mass": 119200.0, "length": 1072, "protein_name": "Integrin alpha-6", "gene_name": "ITGA6", "organism": "Chicken", "refseq_name": "integrin alpha-6 precursor", "refseq_ac": "NP_990620", "gene_names_uniprotkb": "ITGA6", "gene_names_refseq": "ITGA6", "protein_names_uniprotkb": "Integrin alpha-6; VLA-6", "protein_names_refseq": "VLA-6; integrin alpha 6 subunit; integrin alpha-6 precursor; integrin, alpha 6", "tax_id": 9031, "disease": "", "pathway": " (gga:396226)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15520227;1826298;24381169", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X56559.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000236.1. On Sep 23, 2021 this sequence version replaced NP_990620.1., [RefSeq]; Alpha6 integrin is an essential upstream regulator of the IGF-1R survival pathway that regulates the activity level of caspase-3 for it to signal differentiation initiation of lens epithelial cells., [RefSeq, PubMed]; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome., [UniProtKB, UniProtKB]; On laminin, neural crest cells accumulated internalized integrin alpha 6 laminin receptors but not integrin alpha 5 fibronectin receptors; rapid cranial NCC motility on laminin requires integrin recycling, [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038132 neuregulin binding;GO:0046872 metal ion binding;GO:0038023 signaling receptor activity;GO:0031994 insulin-like growth factor I binding", "go_cellular_component": "GO:0009986 cell surface;GO:0034676 integrin alpha6-beta4 complex;GO:0034675 integrin alpha6-beta1 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion;GO:0050900 leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P26007-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26008-1", "uniprot_id": "ITAV_CHICK", "mass": 114389.0, "length": 1034, "protein_name": "Integrin alpha-V", "gene_name": "ITGAV", "organism": "Chicken", "refseq_name": "integrin alpha-V precursor", "refseq_ac": "NP_990770", "gene_names_uniprotkb": "ITGAV", "gene_names_refseq": "ITGAV", "protein_names_uniprotkb": "Integrin alpha-V; Vitronectin receptor subunit alpha", "protein_names_refseq": "integrin alpha-V precursor; integrin alpha-V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); vitronectin receptor alpha subunit; vitronectin receptor subunit alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:396420)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1703004", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M60517.1, SRR13267655.179801.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000235.1. On Sep 23, 2021 this sequence version replaced NP_990770.1., [RefSeq]; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling. ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as receptors for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0034685 integrin alphav-beta6 complex;GO:0034686 integrin alphav-beta8 complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26008-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26009-1", "uniprot_id": "ITA8_CHICK", "mass": 116142.0, "length": 1044, "protein_name": "Integrin alpha-8", "gene_name": "ITGA8", "organism": "Chicken", "refseq_name": "integrin alpha-8 precursor", "refseq_ac": "NP_990619", "gene_names_uniprotkb": "ITGA8", "gene_names_refseq": "ITGA8", "protein_names_uniprotkb": "Integrin alpha-8", "protein_names_refseq": "integrin alpha 8 subunit; integrin alpha-8 precursor; integrin, alpha 8", "tax_id": 9031, "disease": "", "pathway": " (gga:396225)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1714374;7541634;9712662", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X58519.1, SRR13267659.52158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000036.1. On Sep 23, 2021 this sequence version replaced NP_990619.1., [RefSeq]; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0008305 integrin complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P26009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26152-1", "uniprot_id": "ACHA5_CHICK", "mass": 51957.0, "length": 454, "protein_name": "Neuronal acetylcholine receptor subunit alpha-5", "gene_name": "CHRNA5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHRNA5", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:386577)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1698777", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4. Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2. Plays a role in nicotine addiction., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26152-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26153-1", "uniprot_id": "ACHB4_CHICK", "mass": 53785.0, "length": 470, "protein_name": "Neuronal acetylcholine receptor subunit beta-4", "gene_name": "CHRNB4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHRNB4", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-4; N-alpha 3; Neuronal acetylcholine receptor non-alpha-3 chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1698777", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (By similarity). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0060084 synaptic transmission involved in micturition;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26153-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26446-1", "uniprot_id": "PARP1_CHICK", "mass": 113520.0, "length": 1011, "protein_name": "Poly [ADP-ribose] polymerase 1", "gene_name": "PARP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PARP1; ADPRT", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase 1; 2.4.2.-; 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; PARP-1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "1840535;8755499;9521710;9571033", "class_list": "", "function": "Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (By similarity). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Specificity for the different amino acids is conferred by interacting factors, such as hpf1 and nmnat1 (By similarity). Following interaction with hpf1, catalyzes serine ADP-ribosylation of target proteins; hpf1 confers serine specificity by completing the parp1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with hpf1 (By similarity). Following interaction with nmnat1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; nmnat1 confers glutamate and aspartate specificity (By similarity). Parp1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits hpf1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair. Mediates the poly-ADP-ribosylation of a number of proteins. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively (By similarity). Parp1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair (By similarity). In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (By similarity). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II. Acts both as a positive and negative regulator of transcription elongation, depending on the context (By similarity). Poly-ADP-ribose chains generated by parp1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos. Also acts as a negative regulator of the cGAS-STING pathway by mediating poly-ADP-ribosylation and inactivation of cgas. Acts as a negative regulator of adipogenesis by catalyzing poly ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.-;2.4.2.30", "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0003684 damaged DNA binding;GO:0051287 NAD binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P26446-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26584-1", "uniprot_id": "HMGB2_CHICK", "mass": 23828.0, "length": 207, "protein_name": "High mobility group protein B2", "gene_name": "HMGB2", "organism": "Chicken", "refseq_name": "high mobility group protein B2", "refseq_ac": "NP_990817", "gene_names_uniprotkb": "HMGB2; HMG2", "gene_names_refseq": "HMG2b; HMG2; HMGB2", "protein_names_uniprotkb": "High mobility group protein B2; HMG-2; High mobility group protein 2", "protein_names_refseq": "HMG-2; high mobility group protein 2; high mobility group protein B2; non-histone chromosomal protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396482)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14672558;1572546;1601311", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01141389.1, HAEL01001816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000073.1. On Sep 23, 2021 this sequence version replaced NP_990817.1., [RefSeq]; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner (By similarity). Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA (PubMed:14672558). Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0000400 four-way junction DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P26584-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26697-1", "uniprot_id": "GSTA3_CHICK", "mass": 26326.0, "length": 229, "protein_name": "Glutathione S-transferase 3", "gene_name": "", "organism": "Chicken", "refseq_name": "glutathione S-transferase 3", "refseq_ac": "NP_990743", "gene_names_uniprotkb": "", "gene_names_refseq": "GSTAL3; LOC396380", "protein_names_uniprotkb": "Glutathione S-transferase 3; 2.5.1.18; GST class-alpha; GST-CL3", "protein_names_refseq": "GST class-alpha; GST-CL3; glutathione S-transferase 3; glutathione S-transferase class-alpha-like 3", "tax_id": 9031, "disease": "", "pathway": " (gga:396380)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1339283", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M38219.1, CO770475.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M38219.1. On Aug 30, 2004 this sequence version replaced XP_444657.1., [RefSeq]; Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.2;2.5.1.18;1.20.4.2;1.8.5.1;5.3.99.2", "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26697-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26990-1", "uniprot_id": "ARF6_CHICK", "mass": 20096.0, "length": 175, "protein_name": "ADP-ribosylation factor 6", "gene_name": "ARF6", "organism": "Chicken", "refseq_name": "ADP-ribosylation factor 6", "refseq_ac": "NP_001075174", "gene_names_uniprotkb": "ARF6; CPS1", "gene_names_refseq": "ARF6; CPS1", "protein_names_uniprotkb": "ADP-ribosylation factor 6; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor 6", "tax_id": 9031, "disease": "", "pathway": " (gga:428927); (R-GGA-8856828); (R-GGA-8875656)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "3083400", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: HAEK01014227.1, SRR13267654.242768.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000217.1., [RefSeq]; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. May contribute to the regulation of dendritic branching, filopodia extension and dendritic spine development (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;2.7.11.1;3.6.1.5;2.7.10.1", "go_molecular_function": "GO:0005525 GTP binding;GO:0031996 thioesterase binding;GO:0035591 signaling adaptor activity;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903438 positive regulation of mitotic cytokinetic process;GO:0006886 intracellular protein transport;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27092-1", "uniprot_id": "INHBA_CHICK", "mass": 47574.0, "length": 424, "protein_name": "Inhibin beta A chain", "gene_name": "INHBA", "organism": "Chicken", "refseq_name": "inhibin beta A chain precursor", "refseq_ac": "NP_990727", "gene_names_uniprotkb": "INHBA", "gene_names_refseq": "INHBA", "protein_names_uniprotkb": "Inhibin beta A chain; Activin beta-A chain", "protein_names_refseq": "activin beta-A chain; inhibin beta A chain precursor; inhibin beta A chain; inhibin subunit beta A; inhibin, beta A (activin A, activin AB alpha polypeptide)", "tax_id": 9031, "disease": "", "pathway": " (gga:396361)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "2225063;22275431;27664768;7576634;8788196", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01007589.1, U26946.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On Oct 19, 2021 this sequence version replaced NP_990727.1., [RefSeq]; Activin A plays an important role in the development of dorsal root ganglia in an autocrine or paracrine manner., [RefSeq, PubMed]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may play a role in regulating neurotransmitter phenotype., [UniProtKB]; We show that b-catenin is expressed during the pre-patterning of the epithelium prior to papilla induction and second that b-catenin, Ednrb and Inhba are expressed during the induction and patterning of the conjunctival papillae. Furthermore, we identified two genes, b-catenin and Prox1, that may be involved in the induction of the underlying scleral bones, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q90697", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0043509 activin A complex;GO:0043512 inhibin A complex;GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0046880 regulation of follicle-stimulating hormone secretion;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P27092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27093-1", "uniprot_id": "INHBB_CHICK", "mass": 43608.0, "length": 391, "protein_name": "Inhibin beta B chain", "gene_name": "INHBB", "organism": "Chicken", "refseq_name": "inhibin beta B chain precursor", "refseq_ac": "NP_990537", "gene_names_uniprotkb": "INHBB", "gene_names_refseq": "INHBB", "protein_names_uniprotkb": "Inhibin beta B chain; Activin beta-B chain", "protein_names_refseq": "activin beta B; activin beta-B chain; inhibin beta B chain precursor; inhibin beta B chain; inhibin subunit beta B; inhibin, beta B", "tax_id": 9031, "disease": "", "pathway": " (gga:396126)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2225063", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Z71594.1, AF055478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000236.1. On Nov 16, 2021 this sequence version replaced NP_990537.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O73796", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0032869 cellular response to insulin stimulus;GO:0009611 response to wounding;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P27093-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P27463-1", "uniprot_id": "AL1A1_CHICK", "mass": 55809.0, "length": 509, "protein_name": "Aldehyde dehydrogenase 1A1", "gene_name": "ALDH1A1", "organism": "Chicken", "refseq_name": "aldehyde dehydrogenase 1A1", "refseq_ac": "NP_989908", "gene_names_uniprotkb": "ALDH1A1", "gene_names_refseq": "ALDH1A1; GGADHR", "protein_names_uniprotkb": "Aldehyde dehydrogenase 1A1; 1.2.1.19; 1.2.1.28; 1.2.1.36; 1.2.1.3; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; RALDH 1; RalDH1; Retinal dehydrogenase 1", "protein_names_refseq": "3-deoxyglucosone dehydrogenase; ALDH class 1; ALDH-E1; ALHDII; RALDH 1; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase, cytosolic; cytosolic aldehyde dehydrogenase; ralDH1; retinal dehydrogenase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395264)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1559558;19618468", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X58869.4, SRR13267653.4183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN08016555, SAMN08016559 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000094.1. On Dec 1, 2021 this sequence version replaced NP_989908.1., [RefSeq]; Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (By similarity). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification. Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The Aldh1a1 expression pattern is conserved in the developing male gonad and is dependent on the testis-specific transcription factor SOX9., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.1.3;1.2.1.31;1.2.1.8;1.5.1.6;1.2.1.36;1.2.1.19;1.2.1.28", "go_molecular_function": "GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity;GO:0106373 3-deoxyglucosone dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006081 aldehyde metabolic process;GO:0042572 retinol metabolic process;GO:0009449 gamma-aminobutyric acid biosynthetic process;GO:0030392 fructosamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27463-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P28701-1", "uniprot_id": "RXRG_CHICK", "mass": 51233.0, "length": 467, "protein_name": "Retinoic acid receptor RXR-gamma", "gene_name": "RXRG", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RXRG; NR2B3", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid receptor RXR-gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396231)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1652422;8037682", "class_list": "", "function": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91380", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0044323 retinoic acid-responsive element binding", "go_cellular_component": "GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P28701-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P29318-1", "uniprot_id": "EPHA3_CHICK", "mass": 109910.0, "length": 983, "protein_name": "Ephrin type-A receptor 3", "gene_name": "EPHA3", "organism": "Chicken", "refseq_name": "ephrin type-A receptor 3 precursor", "refseq_ac": "NP_990761", "gene_names_uniprotkb": "EPHA3; CEK4; ETK1", "gene_names_refseq": "CEK4; EPHA3; ETK1", "protein_names_uniprotkb": "Ephrin type-A receptor 3; 2.7.10.1; EK4; EPH-like kinase 4; Tyrosine-protein kinase receptor ETK1; cEK4", "protein_names_refseq": "EK4; EPH-like kinase 4; ephrin type-A receptor 3 precursor; ephrin type-A receptor 3; receptor tyrosine kinase; tyrosine-protein kinase receptor ETK1", "tax_id": 9031, "disease": "", "pathway": " (gga:396402)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15014130;1657122;22685584", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M68514.1, SRR13267658.2325.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000019.1. On Sep 23, 2021 this sequence version replaced NP_990761.1., [RefSeq]; Cytoplasmically truncated EphA3 receptor in chick retina caused temporal axons to have reduced responsiveness to posterior tectal repellent activity in vitro and to shift more posteriorly within the map in vivo [EphA3], [RefSeq, PubMed]; Data show that EphA3 receptor ectodomain stimulates nasal retinal ganglion cell (RGC) axon growth in a concentration dependent way., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0051893 regulation of focal adhesion assembly;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0048013 ephrin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P29318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30371-1", "uniprot_id": "TGFB2_CHICK", "mass": 47606.0, "length": 412, "protein_name": "Transforming growth factor beta-2 proprotein", "gene_name": "TGFB2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TGFB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transforming growth factor beta-2 proprotein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1683775;2340183", "class_list": "", "function": "Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively., [UniProtKB, UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0051891 positive regulation of cardioblast differentiation;GO:0060390 regulation of SMAD protein signal transduction;GO:0006468 protein phosphorylation;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P30371-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P30372-1", "uniprot_id": "ACM2_CHICK", "mass": 51565.0, "length": 466, "protein_name": "Muscarinic acetylcholine receptor M2", "gene_name": "CHRM2", "organism": "Chicken", "refseq_name": "muscarinic acetylcholine receptor M2", "refseq_ac": "NP_001025936", "gene_names_uniprotkb": "CHRM2; CM2", "gene_names_refseq": "CHRM2; CM2", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M2", "protein_names_refseq": "m2 muscarinic acetylcholine receptor; muscarinic acetylcholine receptor M2", "tax_id": 9031, "disease": "", "pathway": " (gga:418126); (R-GGA-390648); (R-GGA-418594); (R-GGA-8856825); (R-GGA-8856828)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "16707504;1840593", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888513.380546.1, SRR13267655.14314.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On or before Dec 6, 2021 this sequence version replaced XP_015141117.1, XP_416359.1., [RefSeq]; Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:1840593). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; TGFbeta regulation of M(2) muscarinic receptor expression is dependent on RhoA (M2 muscarinic receptor), [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P30372-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31258-1", "uniprot_id": "HXA11_CHICK", "mass": 33273.0, "length": 297, "protein_name": "Homeobox protein Hox-A11", "gene_name": "HOXA11", "organism": "Chicken", "refseq_name": "homeobox protein Hox-A11", "refseq_ac": "NP_989950", "gene_names_uniprotkb": "HOXA11; GHOX1I", "gene_names_refseq": "GHOX1I; HOX1I; HOXA11; chox-1.9; ghox-1I", "protein_names_uniprotkb": "Homeobox protein Hox-A11; Chox-1.9; Ghox-1I; Homeobox protein Hox-1.9", "protein_names_refseq": "homeo box A11; homeobox protein Hox-1.9; homeobox protein Hox-A11; homeodomain-containing protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395327)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1347239;14706073", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M81250.1, JF317540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1., [RefSeq]; Hoxa-11 and Hoxa-13 are involved in the negative regulation of MyoD expression in limb muscle precursors, [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0007501 mesodermal cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0060272 embryonic skeletal joint morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P31258-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34904-1", "uniprot_id": "GBRG4_CHICK", "mass": 53183.0, "length": 457, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-4", "gene_name": "GABRG4", "organism": "Chicken", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-4 precursor", "refseq_ac": "NP_990576", "gene_names_uniprotkb": "GABRG4", "gene_names_refseq": "GABRE; GABRG4", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-4; GABA(A) receptor subunit gamma-4", "protein_names_refseq": "GABA A receptor; GABA(A) receptor subunit gamma-4; gamma-aminobutyric acid (GABA) A receptor, epsilon; gamma-aminobutyric acid receptor subunit gamma-4 precursor; gamma-aminobutyric acid receptor subunit gamma-4; gamma-aminobutyric acid type A receptor subunit epsilon", "tax_id": 9031, "disease": "", "pathway": " (gga:396173)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8397108", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X73533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000071.1., [RefSeq]; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:2001226 negative regulation of chloride transport;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34904-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35001-1", "uniprot_id": "NEUM_CHICK", "mass": 25631.0, "length": 246, "protein_name": "Neuromodulin", "gene_name": "GAP43", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GAP43", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:427955)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2153895;9813098", "class_list": "", "function": "This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0001786 phosphatidylserine binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0035727 lysophosphatidic acid binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0016198 axon choice point recognition;GO:0040008 regulation of growth;GO:0042246 tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35001-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35331-1", "uniprot_id": "NRCAM_CHICK", "mass": 141852.0, "length": 1284, "protein_name": "Neuronal cell adhesion molecule", "gene_name": "", "organism": "Chicken", "refseq_name": "neuronal cell adhesion molecule precursor", "refseq_ac": "NP_990597", "gene_names_uniprotkb": "", "gene_names_refseq": "NRCAM", "protein_names_uniprotkb": "Neuronal cell adhesion molecule; Neuronal surface protein Bravo; Ng-CAM-related; NgCAM-related cell adhesion molecule; Nr-CAM; gBravo", "protein_names_refseq": "Nr-CAM protein; gBravo; neuronal cell adhesion molecule precursor; neuronal surface protein Bravo; ng-CAM-related; ngCAM-related cell adhesion molecule", "tax_id": 9031, "disease": "", "pathway": " (gga:396202)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1512296;17805548;2045418", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X58482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X58482.1. On Jan 18, 2005 this sequence version replaced XP_429293.1., [RefSeq]; The expression of neuronal cell adhesion molecule appears at the secondary neural tube and notochord and the germinal and mantle layers in chick embryos., [RefSeq, PubMed]; This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Specifically involved in the development of optic fibres in the retina., [UniProtKB]", "predicted_glycosites": 19, "predicted_n_glycosites": 18, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0030246 carbohydrate binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030424 axon", "go_biological_process": "GO:0007417 central nervous system development;GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35331-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35458-1", "uniprot_id": "DCTN1_CHICK", "mass": 135565.0, "length": 1224, "protein_name": "Dynactin subunit 1", "gene_name": "DCTN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DCTN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynactin subunit 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p150-glued", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:426238)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1836789", "class_list": "", "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005938 cell cortex;GO:0030424 axon", "go_biological_process": "GO:0051301 cell division;GO:0090316 positive regulation of intracellular protein transport;GO:0060236 regulation of mitotic spindle organization;GO:0000132 establishment of mitotic spindle orientation;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36381-1", "uniprot_id": "CXA8_CHICK", "mass": 45616.0, "length": 400, "protein_name": "Gap junction alpha-8 protein", "gene_name": "GJA8", "organism": "Chicken", "refseq_name": "gap junction alpha-8 protein", "refseq_ac": "NP_990328", "gene_names_uniprotkb": "GJA8", "gene_names_refseq": "Cx45.6; Cx50; GJA8; connexin-45.6", "protein_names_uniprotkb": "Gap junction alpha-8 protein; Connexin-45.6; Cx45.6", "protein_names_refseq": "connexin 45.6; connexin 50; gap junction alpha-8 protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395846); (R-GGA-190861)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10702244;11448971;14762116;21454606;22418432;27143357;29487175;33180092;8049527;8840185", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: SRR13267659.288430.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000019.1. On Dec 3, 2021 this sequence version replaced NP_990328.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cx50 hemichannels mediate transport of reductant glutathione into lens fiber cells and protect cells against oxidative stress. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanosensitive collaboration between integrins and connexins allows nutrient and antioxidant transport into the lens., [RefSeq, PubMed]; Results suggest that both caspase-1 and -3 are responsible for the cleavage at the C terminus of connexin 50 (Cx50) during lens development., [RefSeq, PubMed]; Structural component of eye lens gap junctions (PubMed:8049527). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:8049527)., [UniProtKB, PubMed, UniProtKB]; The role of the charged residues at the end of TM-1 in voltage sensing in Cx26, Cx46, and Cx50., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q92144", "ec_number_list": "", "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P36381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37383-1", "uniprot_id": "RAD51_CHICK", "mass": 36904.0, "length": 339, "protein_name": "DNA repair protein RAD51 homolog 1", "gene_name": "RAD51A", "organism": "Chicken", "refseq_name": "DNA repair protein RAD51 homolog 1", "refseq_ac": "NP_990504", "gene_names_uniprotkb": "RAD51A; RAD51", "gene_names_refseq": "RAD51A; RAD51", "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 1; 3.6.4.-", "protein_names_refseq": "DNA repair protein RAD51 homolog 1; RAD51 homolog (RecA homolog, E. coli); homolog to S.cerevisiae", "tax_id": 9031, "disease": "", "pathway": " (gga:396086); (R-GGA-265976); (R-GGA-351433); (R-GGA-5685938); (R-GGA-5685942); (R-GGA-5693537); (R-GGA-5693568); (R-GGA-5693579); (R-GGA-5693616); (R-GGA-912446)", "pathway_count": 10, "publication_count": 17, "publication_id_list": "10938124;11376695;12422221;14580352;15059890;15800615;16687415;17123873;17349954;17515904;17928296;18794841;19540122;21779174;27694619;8479908;9008167", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000575.1, HAEL01002101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000212.1., [RefSeq]; BRCA2 might serve as a platform to recruit various RAD51 mediators at the appropriate position at the DNA-damage site., [RefSeq, PubMed]; Collectively, the FANCI-FANCD2 complex-mediated stabilization of the RAD51 nucleoprotein filament may function to prevent destructive DNA degradation by exonucleases during replication and at stalled replication forks., [RefSeq, PubMed]; FA proteins work together with BRCA2/Rad51-mediated homologous recombination in double strand break repair, whereas the FA pathway plays a role that is independent of the CTD of BRCA2 in interstrand cross-link repair, [RefSeq, PubMed]; Homologous DNA recombinase that catalyzes strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis. Recruited to resolve stalled replication forks during replication stress (By similarity). Also required for homologous recombination during meiosis by acting as an non-catalytic accessory factor for DMC1 recombinase, enabling proper chromosome pairing and crossing over (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Rad51 is assembled by H2AX and XRCC3 in different pathways., [RefSeq, PubMed]; Results suggest that Rad51 binding by the C-terminal Brca2 motif is dispensable for the execution of homologous DNA recombination but instead links the disassembly of Rad51 complexes to mitotic entry., [RefSeq, PubMed]; Suggest a model for the vertebrate cell cycle in which homologous DNA recombination during the G2 phase is separated from DNA replication in S phase and chromosome segregation in M, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;2.3.1.48;5.6.1.6;5.6.2.4;2.7.11.1;3.6.4.10;6.5.1.1;3.6.4.12;5.6.2.3;2.7.4.3;3.1.-.-;2.7.7.7;4.2.99.18;7.2.2.-;3.6.5.-;5.6.2.1;3.6.4.-;5.6.2.-;2.3.2.27;2.7.7.49;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0070182 DNA polymerase binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006312 mitotic recombination;GO:0010833 telomere maintenance via telomere lengthening;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P37383-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38529-1", "uniprot_id": "HSF1_CHICK", "mass": 53599.0, "length": 491, "protein_name": "Heat shock factor protein 1", "gene_name": "HSF1", "organism": "Chicken", "refseq_name": "heat shock factor protein 1", "refseq_ac": "NP_001292185", "gene_names_uniprotkb": "HSF1", "gene_names_refseq": "HSF 1; HSF 3A; HSF1; HSTF 1; HSTF 3A", "protein_names_uniprotkb": "Heat shock factor protein 1; HSF 1; HSF 3A; HSTF 1; HSTF 3A; Heat shock transcription factor 1", "protein_names_refseq": "heat shock factor protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420362)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27890044;30339219;8455593", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L06098.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from L06098.1., [RefSeq]; Co-enzyme Q10 can protect chicken hearts from in vivo heat stress by inducing HSF1 binding activity and Hsp70 expression., [RefSeq, PubMed]; Data suggest that exposure to high environmental temperature up-regulates expression of heat shock factor 1 (HSF1) mRNA, HSF3 mRNA, and heat shock protein 70 (HSP70) mRNA/protein in liver, heart, and breast muscle; dietary supplementation with manganese down-regulates expression of HSP70 in breast muscle., [RefSeq, PubMed]; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:8455593). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (By similarity). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells. Plays a role in nuclear export of stress-induced mRNA. Plays a role in the regulation of mitotic progression. Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "I7GGU6", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0031072 heat shock protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P38529-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38530-1", "uniprot_id": "HSF2_CHICK", "mass": 62827.0, "length": 564, "protein_name": "Heat shock factor protein 2", "gene_name": "HSF2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock factor protein 2; HSF 2; HSF 3B; HSTF 2; HSTF 3B; Heat shock transcription factor 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8455593", "class_list": "", "function": "DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 shows constitutive DNA binding activity, even without heat shock., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "I7FPS8", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0050821 protein stabilization;GO:0031397 negative regulation of protein ubiquitination;GO:0009416 response to light stimulus;GO:1903935 response to sodium arsenite", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P38530-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41534-1", "uniprot_id": "PACA_CHICK", "mass": 19561.0, "length": 175, "protein_name": "Glucagon family neuropeptides", "gene_name": "ADCYAP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADCYAP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Glucagon family neuropeptides; GHRH; Growth hormone-releasing hormone", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9022048", "class_list": "", "function": "PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Primary role of GRF is to release GH from the pituitary., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53WW0", "ec_number_list": "", "go_molecular_function": "GO:0016521 pituitary adenylate cyclase activating polypeptide activity;GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding;GO:0031892 type 2 vasoactive intestinal polypeptide receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043204 perikaryon;GO:0043005 neuron projection;GO:0044297 cell body;GO:0070852 cell body fiber", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0010628 positive regulation of gene expression;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P41534-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42558-1", "uniprot_id": "RAN_CHICK", "mass": 24427.0, "length": 216, "protein_name": "GTP-binding nuclear protein Ran", "gene_name": "RAN", "organism": "Chicken", "refseq_name": "GTP-binding nuclear protein Ran", "refseq_ac": "NP_990589", "gene_names_uniprotkb": "RAN", "gene_names_refseq": "RANP1; RAN", "protein_names_uniprotkb": "GTP-binding nuclear protein Ran; 3.6.5.-; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein", "protein_names_refseq": "GTP-binding nuclear protein Ran; GTPase Ran; RAN, member RAS oncogene family pseudogene 1; ras-like protein TC4; ras-related nuclear protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396193); (R-GGA-1655829); (R-GGA-5578749); (R-GGA-9615933)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "1633874", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01014292.1, DR415675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMN08016560 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.1.26.n2;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046982 protein heterodimerization activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:1902570 protein localization to nucleolus;GO:0061015 snRNA import into nucleus;GO:0000054 ribosomal subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P42558-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42683-1", "uniprot_id": "LCK_CHICK", "mass": 58140.0, "length": 508, "protein_name": "Proto-oncogene tyrosine-protein kinase LCK", "gene_name": "LCK", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LCK", "gene_names_refseq": "", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase LCK; 2.7.10.2; Protein-tyrosine kinase C-TKL; p56tk1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1545804;3321053", "class_list": "", "function": "Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53WS8", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0000242 pericentriolar material", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0050853 B cell receptor signaling pathway;GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;GO:0009410 response to xenobiotic stimulus;GO:0050870 positive regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P42683-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47807-1", "uniprot_id": "MYO1A_CHICK", "mass": 119277.0, "length": 1045, "protein_name": "Unconventional myosin-Ia", "gene_name": "MYO1A", "organism": "Chicken", "refseq_name": "unconventional myosin-Ia", "refseq_ac": "NP_990494", "gene_names_uniprotkb": "MYO1A; MYHL", "gene_names_refseq": "MYO1A", "protein_names_uniprotkb": "Unconventional myosin-Ia; BBM-I; BBMI; Brush border myosin I; MIHC; Myosin I heavy chain", "protein_names_refseq": "BBM-I; BBMI; MIHC; brush border myosin I heavy chain; myosin-Ia; unconventional myosin-Ia", "tax_id": 9031, "disease": "", "pathway": " (gga:396072)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25185950;2687288;8681398;8994973", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U04049.1, SRR13267654.245075.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000490.1. On Sep 23, 2021 this sequence version replaced NP_990494.1., [RefSeq]; Could play an important role in morphogenesis and function of intestinal microvilli., [UniProtKB]; The piRNA-linked gene MYO1A was more highly expressed in the chicken primordial germ cells than that of stage X blastoderms, gonadal stromal cells and embryonic fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90573", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0016197 endosomal transport;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47990-1", "uniprot_id": "XDH_CHICK", "mass": 149614.0, "length": 1358, "protein_name": "Xanthine dehydrogenase/oxidase", "gene_name": "XDH", "organism": "Chicken", "refseq_name": "xanthine dehydrogenase/oxidase", "refseq_ac": "NP_990458", "gene_names_uniprotkb": "XDH", "gene_names_refseq": "AOX1; XDH", "protein_names_uniprotkb": "Xanthine dehydrogenase/oxidase; XOR; Xanthine oxidoreductase", "protein_names_refseq": "aldehyde oxidase 1; xanthine dehydrogenase/oxidase", "tax_id": 9031, "disease": "", "pathway": " (gga:396025); (R-GGA-421178)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19654053;25243829;26119168;6953967;7852355", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D13221.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000060.1. On Sep 23, 2021 this sequence version replaced NP_990458.1., [RefSeq]; Allopurinol increased liver xanthine oxidoreductase activity., [RefSeq, PubMed]; Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury., [RefSeq, PubMed]; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species., [UniProtKB, UniProtKB]; Nephropathogenic infectious bronchitis virus infection could cause the increases of renal xanthine oxidase (XOD) gene transcription and serum XOD activity, leading to hyperuricemia and reduction of antioxidants in the body., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.17.1.4;1.17.3.2", "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0005506 iron ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0009115 xanthine catabolic process;GO:0034418 urate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P47990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48434-1", "uniprot_id": "SOX9_CHICK", "mass": 54848.0, "length": 494, "protein_name": "Transcription factor SOX-9", "gene_name": "SOX9", "organism": "Chicken", "refseq_name": "transcription factor SOX-9", "refseq_ac": "NP_989612", "gene_names_uniprotkb": "SOX9", "gene_names_refseq": "SOX-9; SOX9", "protein_names_uniprotkb": "Transcription factor SOX-9", "protein_names_refseq": "transcription factor SOX-9", "tax_id": 9031, "disease": "", "pathway": " (gga:374148); (R-GGA-3769402); (R-GGA-8878166)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10340758;15592404;23382206;24389048;24643018;28386540;31024001;33733477;9858536", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.99384.1, AB012236.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000317.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Avian digits may represent an evolutionary specialization of digit development consequence of a posterior polarization of signals responsible for limb outgrowth. In contrast, the pentadactyl autopod of mouse and turtle embryos may result from the uniform expansion (like opening a fan) of the signals that coordinate proliferation and differentiation of the skeletal progenitors. Publication Status: Online-Only, [RefSeq, PubMed]; Light-induced local gene expression in primary chick cell culture system., [RefSeq, PubMed]; The chondrogenic inhibition and increased cell death observed in micromass cultures subjected to Uhrf genes gain-of-function experiments involved a precocious downregulation of Sox9 gene. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest that ETS1 and SOX9 may act as pan-neural crest regulators of the migratory cranial neural crest, [RefSeq, PubMed]; Transcription factor that plays a key role in chondrocytes differentiation and skeletal development (PubMed:10340758, PubMed:9858536). Specifically binds the 5'-ACAAAG-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including COL2A1 (PubMed:10340758, PubMed:9858536). Plays a central role in successive steps of chondrocyte differentiation. Absolutely required for precartilaginous condensation, the first step in chondrogenesis during which skeletal progenitors differentiate into prechondrocytes (By similarity). Together with SOX5 and SOX6, required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes, the second step in chondrogenesis (By similarity). Later, required to direct hypertrophic maturation and block osteoblast differentiation of growth plate chondrocytes: maintains chondrocyte columnar proliferation, delays prehypertrophy and then prevents osteoblastic differentiation of chondrocytes (By similarity). Also required for chondrocyte hypertrophy, both indirectly, by keeping the lineage fate of chondrocytes, and directly, by remaining present in upper hypertrophic cells (By similarity). Low lipid levels are the main nutritional determinant for chondrogenic commitment of skeletal progenitor cells: when lipids levels are low, FOXO transcription factors promote expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). In addition to cartilage development, also acts as a regulator of proliferation and differentiation in epithelial stem/progenitor cells (By similarity). In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination (PubMed:23382206)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1P307;O73668", "ec_number_list": "", "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0034236 protein kinase A catalytic subunit binding;GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:1904864 negative regulation of beta-catenin-TCF complex assembly;GO:0003170 heart valve development;GO:0072190 ureter urothelium development;GO:1903011 negative regulation of bone development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P48434-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48984-1", "uniprot_id": "TEAD4_CHICK", "mass": 49443.0, "length": 438, "protein_name": "Transcriptional enhancer factor TEF-3", "gene_name": "TEAD4", "organism": "Chicken", "refseq_name": "transcriptional enhancer factor TEF-3 isoform 1", "refseq_ac": "NP_001001337", "gene_names_uniprotkb": "TEAD4; TEF-1; TEF3", "gene_names_refseq": "RTEF-1; TEAD-4; TEAD4; TEF-1; TEF-3; TEF3", "protein_names_uniprotkb": "Transcriptional enhancer factor TEF-3; M-CAT-binding factor; RTEF-1; TEA domain family member 4; TEAD-4; TEF-1", "protein_names_refseq": "M-CAT binding factor; TEA domain family member 4; transcriptional enhancer factor TEF-3 isoform 1; transcriptional enhancer factor TEF-3", "tax_id": 9031, "disease": "", "pathway": " (gga:395542)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8106348", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U06848.1, SRR12888488.154426.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JAENSK010000015.1. This gene encodes a transcription factor which is a member of the transcriptional enhancer factor (TEF) family. Members of this family are characterized by a TEA/ATTS DNA-binding domain. This factor, which is highly expressed in muscle, binds to a promoter element called M-CAT, a motif found in promoters of muscle specific genes. Alternatively spliced transcripts encoding distinct isoforms, which are encoded through the use of a non-AUG (UUG) translation initiation codon, have been described. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2), also referred to as TEF-1A', differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Isoform B has probably a transactivation capacity that is lacking in the other isoforms. Isoform D may be defective in DNA binding., [UniProtKB]; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). Binds m-cat elements from muscle-specific promoters and differentially activate transcription., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0035329 hippo signaling;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50146-1", "uniprot_id": "GNAI1_CHICK", "mass": 40378.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-1", "gene_name": "GNAI1", "organism": "Chicken", "refseq_name": "guanine nucleotide-binding protein G(i) subunit alpha-1", "refseq_ac": "NP_990734", "gene_names_uniprotkb": "GNAI1", "gene_names_refseq": "GNAI1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(i) subunit alpha-1; 3.6.5.-; Adenylate cyclase-inhibiting G alpha protein", "protein_names_refseq": "Gi1 protein alpha-subunit; adenylate cyclase-inhibiting G alpha protein; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide-binding protein G(i) subunit alpha-1", "tax_id": 9031, "disease": "", "pathway": " (gga:396368)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7821803", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L24548.1, SRR13267661.22210.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992648 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Sep 20, 2021 this sequence version replaced NP_990734.1., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (By similarity). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0051301 cell division;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:1904322 cellular response to forskolin;GO:1904778 positive regulation of protein localization to cell cortex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50146-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50211-1", "uniprot_id": "ISL1_CHICK", "mass": 39034.0, "length": 349, "protein_name": "Insulin gene enhancer protein ISL-1", "gene_name": "ISL1", "organism": "Chicken", "refseq_name": "insulin gene enhancer protein ISL-1", "refseq_ac": "NP_990745", "gene_names_uniprotkb": "ISL1; ISL-1", "gene_names_refseq": "ISL-1; ISL1; ISLET-1", "protein_names_uniprotkb": "Insulin gene enhancer protein ISL-1; Islet-1", "protein_names_refseq": "ISL1 transcription factor, LIM/homeodomain, (islet-1); domesticus (clone 1.7 kB) islet-1; insulin gene enhancer protein ISL-1", "tax_id": 9031, "disease": "", "pathway": " (gga:396383)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15281076;16047166;25747715;25752780;7528105", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L35567.1, SRR13267655.147332.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000089.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Acts as a transcriptional regulator (PubMed:7528105). Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (PubMed:7528105). Acts in conjunction with LHX1, LHX3 and ISL2 (PubMed:7528105). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Data indicate that myocardial markers ISL1, TNNI2 and NKX2-5 and HCN4 were studied in sequential stages of chick embryo development., [RefSeq, PubMed]; Knockdown or loss of function of Cadherin-6B suppressed the generation of Islet-1-expressing cells in the dorsal neural tube, but not the Lim-1/2 positive dorsal cell population., [RefSeq, PubMed]; The data of this study is consistent with a role for islet-1 in differentiating inner ear neurons and sensory epithelia cells, perhaps in the specification of cellular subtypes in conjunction with other LIM/homeodomain proteins., [RefSeq, PubMed]; These results suggest that Islet-1 is involved in determining the cell lineages, proliferation, differentiation and maintenance of hormone-secreting functions of pituitary gonadotrophs and thyrotrophs of chick embryo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0060384 innervation;GO:0048880 sensory system development;GO:0048936 peripheral nervous system neuron axonogenesis;GO:0060913 cardiac cell fate determination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50211-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50577-1", "uniprot_id": "DLX5_CHICK", "mass": 30949.0, "length": 286, "protein_name": "Homeobox protein DLX-5", "gene_name": "DLX5", "organism": "Chicken", "refseq_name": "homeobox protein DLX-5", "refseq_ac": "NP_989490", "gene_names_uniprotkb": "DLX5; DLX-5", "gene_names_refseq": "DLX-5; DLX5", "protein_names_uniprotkb": "Homeobox protein DLX-5; cDlx", "protein_names_refseq": "cDlx; distal-less homeo box 5; homeobox protein DLX-5", "tax_id": 9031, "disease": "", "pathway": " (gga:373969)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10894982;12895028;15672396;17027239;17335796;21270050;27416760;8541214", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U25274.1, HAEL01001953.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02738221, SAMN02738223 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000036.1. On Aug 30, 2004 this sequence version replaced XP_429224.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Dlx5 and related Dlx factors play a pivotal role in the onset of differentiation of chick calvaria osteoblasts., [RefSeq, PubMed]; Dlx5 has roles during multiple stages of chondrocyte differentiation and is a general regulator of differentiation in the skeleton, [RefSeq, PubMed]; Ectethmoid formation depends upon Dlx5 and Dlx6 expression in a restricted ectodermal territory of the anterior neural folds, [RefSeq, PubMed]; Inner ear expression patterns of Dlx3, Dlx5, and Dlx6 were examined during the first 7 days of chicken embryonic development., [RefSeq, PubMed]; Investigated the domain requirements and transcriptional activities associated with Dlx5- and Dlx6-mediated chondrogenesis, [RefSeq, PubMed]; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA., [UniProtKB]; We find Dlx5 and Dlx6 to be quantitatively indistinguishable on a variety of natural cis-regulatory sequences in a heterologous cellular context but observed quantitatively different transcriptional outputs in cells that normally express these genes, suggesting differential interactions with co-evolved co-activators., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q549L3", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0030154 cell differentiation;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P50577-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50593-1", "uniprot_id": "GPC1_CHICK", "mass": 61084.0, "length": 550, "protein_name": "Glypican-1", "gene_name": "GPC1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GPC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Glypican-1; Heparan sulfate proteoglycan core protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8875073", "class_list": "", "function": "Cell surface proteoglycan that bears heparan sulfate. Modulates Wnt-signaling pathway., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016477 cell migration;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway;GO:1902723 negative regulation of skeletal muscle satellite cell proliferation;GO:1902725 negative regulation of satellite cell differentiation;GO:1902724 positive regulation of skeletal muscle satellite cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50593-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51030-1", "uniprot_id": "WNT8C_CHICK", "mass": 40042.0, "length": 357, "protein_name": "Protein Wnt-8c", "gene_name": "WNT8C", "organism": "Chicken", "refseq_name": "protein Wnt-8c precursor", "refseq_ac": "NP_990862", "gene_names_uniprotkb": "WNT8C", "gene_names_refseq": "CWNT-8C; WNT8A; Wnt8c", "protein_names_uniprotkb": "Protein Wnt-8c; CWnt-8", "protein_names_refseq": "CWnt-8; Wnt-8C; protein Wnt-8c precursor; protein Wnt-8c; wingless-type MMTV integration site family, member 8A", "tax_id": 9031, "disease": "", "pathway": " (gga:396543)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11290326;15037548;17507413;7916678", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U02097.1, AB193181.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992544 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1. On Sep 23, 2021 this sequence version replaced NP_990862.1., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Is likely to signal over only few cell diameters. May be involved in the regulation of axis formation and in the rhombomere specification., [UniProtKB]; Results of injection of wnt8c and PPARgamma RNAs reveal thatPPARgamma sinaling potentiates Wnt processes, [RefSeq, PubMed]; WNT8A (Wnt-8c) regulates embryonic hindlimb morphogenesis via FGF signaling and WNT/CTNNB1 signaling, [RefSeq, PubMed]; Wnt signals provide a timing mechanism for the FGF-retinoid differentiation switch during vertebrate body axis extension., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030182 neuron differentiation;GO:0060070 canonical Wnt signaling pathway;GO:0060173 limb development;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0035116 embryonic hindlimb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51030-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51475-1", "uniprot_id": "OPSP_CHICK", "mass": 38174.0, "length": 351, "protein_name": "Pinopsin", "gene_name": "", "organism": "Chicken", "refseq_name": "pinopsin", "refseq_ac": "NP_990740", "gene_names_uniprotkb": "", "gene_names_refseq": "OPNP; opsin", "protein_names_uniprotkb": "Pinopsin; P-opsin; Pineal gland-specific opsin; Pineal opsin", "protein_names_refseq": "P-opsin; pineal gland-specific opsin; pineal opsin; pinopsin", "tax_id": 9031, "disease": "", "pathway": " (gga:396377)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "7878470;7969427;9756926", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U15762.1 [ECO:0000332] RNAseq introns :: partial sample support SAMN05341171 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U15762.1., [RefSeq]; Produces a slow and prolonged phototransduction response consistent with the non-visual function of pineal photoreception., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P79794", "ec_number_list": "", "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0097232 lamellar body membrane;GO:0036064 ciliary basal body;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51475-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51901-1", "uniprot_id": "ANXA6_CHICK", "mass": 75219.0, "length": 671, "protein_name": "Annexin A6", "gene_name": "ANXA6", "organism": "Chicken", "refseq_name": "annexin A6 isoform 1", "refseq_ac": "NP_990061", "gene_names_uniprotkb": "ANXA6; ANX6", "gene_names_refseq": "ANXA6", "protein_names_uniprotkb": "Annexin A6; 67 kDa calelectrin; Annexin VI; Annexin-6; CPB-II; Calphobindin-II; Chromobindin-20; Lipocortin VI; P68; P70; Protein III", "protein_names_refseq": "67 kDa calelectrin; CPB-II; P68; P70; annexin A6 isoform 1; annexin-6; calcium- and phospholipid-binding protein; calphobindin-II; chromobindin-20; lipid-dependent Ca(2+)-binding protein annexin VI; lipocortin VI", "tax_id": 9031, "disease": "", "pathway": " (gga:395481)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22984583;25976293;28315296;8267590", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: S67466.1, HAEK01094399.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000256.1. On Nov 5, 2021 this sequence version replaced NP_990061.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Annexin A6 plays a pivotal role in modulating the formation of cranial migratory neural crest cells during vertebrate development, [RefSeq, PubMed]; Data show that knockdown of Annexin A6 impacts projection outgrowth from cranial sensory neurons., [RefSeq, PubMed]; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores (By similarity)., [UniProtKB]; The dynamic expression of Annexin A6 in various embryonic cell types may allow Annexin A6 to serve distinct functions throughout embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0042470 melanosome", "go_biological_process": "GO:0006816 calcium ion transport;GO:0097190 apoptotic signaling pathway;GO:0001755 neural crest cell migration;GO:0051560 mitochondrial calcium ion homeostasis;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51901-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53411-1", "uniprot_id": "LHX1_CHICK", "mass": 44845.0, "length": 406, "protein_name": "LIM/homeobox protein Lhx1", "gene_name": "LHX1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LHX1; LIM-1; LIM1", "gene_names_refseq": "", "protein_names_uniprotkb": "LIM/homeobox protein Lhx1; Homeobox protein Lim-1; LIM homeobox protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396381)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7528105", "class_list": "", "function": "Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0060429 epithelium development;GO:0060993 kidney morphogenesis;GO:2001141 regulation of RNA biosynthetic process;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53411-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53412-1", "uniprot_id": "LHX3_CHICK", "mass": 43805.0, "length": 395, "protein_name": "LIM/homeobox protein Lhx3", "gene_name": "LHX3", "organism": "Chicken", "refseq_name": "LIM/homeobox protein Lhx3", "refseq_ac": "NP_001025506", "gene_names_uniprotkb": "LHX3; LIM-3; LIM3", "gene_names_refseq": "LHX3; LIM3; lim-3", "protein_names_uniprotkb": "LIM/homeobox protein Lhx3; Homeobox protein LIM-3; LIM homeobox protein 3", "protein_names_refseq": "LIM homeobox protein 3; LIM/homeobox protein Lhx3; homeobox protein LIM-3", "tax_id": 9031, "disease": "", "pathway": " (gga:373940)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16948785;18647663;22461196;29139167;7528105", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L35570.1, SRR13267660.7846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051, SAMN05341171 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000308.1. On Aug 15, 2005 this sequence version replaced XP_415412.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Embryonic chick pituitary gland consists of two different regions where delta-crystallin and Lhx3 are expressed., [RefSeq, PubMed]; Lim3 and Pax6 are expressed from stage 10 in the prospective hypophyseal placode, [RefSeq, PubMed]; May be involved in regulating the development and functional maturation of the pineal gland., [RefSeq, PubMed]; Sustained overexpression of Nolz1 in the retina gave fewer Lim3/Lhx3 bipolar cells., [RefSeq, PubMed]; Transcription factor (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54097-1", "uniprot_id": "TECTB_CHICK", "mass": 36899.0, "length": 329, "protein_name": "Beta-tectorin", "gene_name": "TECTB", "organism": "Chicken", "refseq_name": "beta-tectorin precursor", "refseq_ac": "NP_990694", "gene_names_uniprotkb": "TECTB", "gene_names_refseq": "TECTB", "protein_names_uniprotkb": "Beta-tectorin", "protein_names_refseq": "beta-tectorin precursor; beta-tectorin", "tax_id": 9031, "disease": "", "pathway": " (gga:396320)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1490898;7721949;9736748", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L38519.1, HAEK01059142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000232.1. On Sep 23, 2021 this sequence version replaced NP_990694.1., [RefSeq]; One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P54097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54755-1", "uniprot_id": "EPHA5_CHICK", "mass": 112246.0, "length": 1013, "protein_name": "Ephrin type-A receptor 5", "gene_name": "EPHA5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EPHA5; CEK7", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-A receptor 5; 2.7.10.1; EK7; EPH-like kinase 7; cEK7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "7958948;8510926", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q07495", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0032593 insulin-responsive compartment", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0021766 hippocampus development;GO:0007413 axonal fasciculation;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P54755-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56519-1", "uniprot_id": "HDAC2_CHICK", "mass": 55153.0, "length": 488, "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HDAC2", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone deacetylase 2; 3.5.1.-; 3.5.1.98; HD2; Protein deacylase HDAC2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Also deacetylates non-histone proteins. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation, delactylation and de-2-hydroxyisobutyrylation, respectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.98;3.5.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004407 histone deacetylase activity;GO:0160009 histone decrotonylase activity;GO:0160010 protein de-2-hydroxyisobutyrylase activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035098 ESC/E(Z) complex;GO:0000118 histone deacetylase complex;GO:0016581 NuRD complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P56519-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56520-1", "uniprot_id": "HDAC3_CHICK", "mass": 48902.0, "length": 428, "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HDAC3", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone deacetylase 3; 3.5.1.-; 3.5.1.98; HD3; Protein deacetylase HDAC3; Protein deacylase HDAC3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395506)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10748092", "class_list": "", "function": "Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes, such as N-Cor repressor complex, which activate the histone deacetylase activity. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Also functions as a deacetylase for non-histone targets. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl), lactoyl (lactyl), 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) and isonicotinyl acyl groups from lysine residues, leading to protein decrotonylation, delactylation, de-2-hydroxyisobutyrylation and deisonicotinylation, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.98;3.5.1.-", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0004407 histone deacetylase activity;GO:0033558 protein lysine deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0042752 regulation of circadian rhythm;GO:0006325 chromatin organization;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56520-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P56732-1", "uniprot_id": "AVR2_CHICK", "mass": 16435.0, "length": 150, "protein_name": "Avidin-related protein 2", "gene_name": "AVR2", "organism": "Chicken", "refseq_name": "avidin-related protein 2 precursor", "refseq_ac": "NP_001025519", "gene_names_uniprotkb": "AVR2", "gene_names_refseq": "AVR2; avr6", "protein_names_uniprotkb": "Avidin-related protein 2", "protein_names_refseq": "avidin-related protein 2 precursor; avidin-related protein 6 (AVR6)", "tax_id": 9031, "disease": "", "pathway": " (gga:395367)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11167523;11964162;16212654;25002549;25630677;8125122", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888551.136446.1, SRR12888550.6901.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000087.1. On Aug 8, 2005 this sequence version replaced XP_429213.1., [RefSeq]; Forms a strong non-covalent specific complex with biotin., [UniProtKB, PubMed]; The effect of biotin supplementation on avidin-related protein-2 (AVR2) expression, and the relationship between biotin administration and oviductal expression of avidin and AVR2, was dependent on the hen's age, being higher in the young hens., [RefSeq, PubMed]; The fertility rate and oviductal expression of avidin and AVR2 were dichotomously affected by oral biotin in low- and high-fertility line hens, where only low-fertility birds showed improvements in these attributes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q546L5", "ec_number_list": "", "go_molecular_function": "GO:0009374 biotin binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0015878 biotin transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56732-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P60706-1", "uniprot_id": "ACTB_CHICK", "mass": 41737.0, "length": 375, "protein_name": "Actin, cytoplasmic 1", "gene_name": "ACTB", "organism": "Chicken", "refseq_name": "actin, cytoplasmic 1", "refseq_ac": "NP_990849", "gene_names_uniprotkb": "ACTB", "gene_names_refseq": "ACTB; Bact; actin", "protein_names_uniprotkb": "Actin, cytoplasmic 1; 3.6.4.-; Beta-actin", "protein_names_refseq": "Bact; actin, cytoplasmic 1; actin; beta-actin; cytoplasmic 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396526)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11955010;18612635;19710142;21789544;23099774;30626964;6324080", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01012163.1, HAEK01000597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Aug 30, 2004 this sequence version replaced XP_429312.1., [RefSeq]; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA., [UniProtKB, UniProtKB]; Beta-actin is a substrate for native chick telencephalon-cell transglutaminase 1 and recombinant human TGM1 in vitro. TGM1 stabilizes the actin cytoskeleton by cross-linking., [RefSeq, PubMed]; Results show that despite being commonly used housekeeping genes neither GAPDH mRNA nor beta-actin mRNA is expressed in all cell types or tissues at high levels. Strikingly, expression levels are very low in some organs., [RefSeq, PubMed]; Results suggest that actin acts as a classical transcription factor for the virus by divalent-cation-dependent binding to the viral template and that profilin acts as a transcriptional cofactor, in part by associating with actin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02570;P70514;P99021;Q11211;Q64316", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding;GO:0098973 structural constituent of postsynaptic actin cytoskeleton", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P60706-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61798-1", "uniprot_id": "APTX_CHICK", "mass": 36018.0, "length": 316, "protein_name": "Aprataxin", "gene_name": "APTX", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "APTX", "gene_names_refseq": "", "protein_names_uniprotkb": "Aprataxin; 3.6.1.71; 3.6.1.72; FHA-HIT; Forkhead-associated domain histidine triad-like protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16964241", "class_list": "", "function": "DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.71;3.6.1.72", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003725 double-stranded RNA binding;GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity;GO:0003697 single-stranded DNA binding;GO:0030983 mismatched DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000012 single strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62801-1", "uniprot_id": "H4_CHICK", "mass": 11367.0, "length": 103, "protein_name": "Histone H4", "gene_name": "H4-III; H4-II; H4-IV; H4-I; H4-VII; H4-VI; H4-V", "organism": "Chicken", "refseq_name": "histone H4", "refseq_ac": "NP_001032932", "gene_names_uniprotkb": "H4-III; H4-II; H4-IV; H4-I; H4-VII; H4-VI; H4-V", "gene_names_refseq": "4-VII; H4-III; H4-II; H4-IV; H4-I; H4-VII; H4-VI; H4-V; H4/o; H4C37; HIST1H47; HIST2H4B", "protein_names_uniprotkb": "Histone H4", "protein_names_refseq": "histone 2, H4b; histone H4 (aa 1-103); histone H4-VII; histone H4; histone cluster 1, histone class H4, member 7 (similar to human histone cluster 1, class H4 genes); histone cluster 2, H4b", "tax_id": 9031, "disease": "", "pathway": " (gga:100858049); (gga:100858319); (gga:417946); (gga:417950); (gga:427884); (gga:770005); (gga:770142); (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-3214841); (R-GGA-3214842); (R-GGA-3214847); (R-GGA-3214858); (R-GGA-427413); (R-GGA-4551638); (R-GGA-5250924); (R-GGA-5693565); (R-GGA-5693571); (R-GGA-5693607); (R-GGA-606279); (R-GGA-68616); (R-GGA-69473); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 36, "publication_count": 7, "publication_id_list": "11092917;1748315;1946434;25860507;4000938;6190814;8804862", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BU462746.1, HAEK01110828.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Dec 21, 2005 this sequence version replaced XP_416191.1., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02304;P02305", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62801-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63247-1", "uniprot_id": "RACK1_CHICK", "mass": 35077.0, "length": 317, "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "RACK1", "organism": "Chicken", "refseq_name": "small ribosomal subunit protein RACK1", "refseq_ac": "NP_001004378", "gene_names_uniprotkb": "RACK1; GNB2L1", "gene_names_refseq": "C12-3; GNB2L1; RACK1; c12.3", "protein_names_uniprotkb": "Small ribosomal subunit protein RACK1; Guanine nucleotide-binding protein subunit beta-like protein 12.3; RACK1; Receptor for activated C kinase; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1", "protein_names_refseq": "Guanine nucleotide-binding protein beta subunit2-like 1; MHC B complex protein 12.3; guanine nucleotide binding 12.3; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide-binding protein beta subunit 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; guanine nucleotide-binding protein subunit beta-like protein 12.3; guanine nucleotide-binding protein-related; receptor of activated protein C kinase 1; receptor of activated protein kinase C 1; small ribosomal subunit protein RACK1", "tax_id": 9031, "disease": "", "pathway": " (gga:417044)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15128875;15744538;17513765;2499885", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN210893.1, HAEL01006482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000283.1. On Sep 17, 2004 this sequence version replaced XP_415332.1. Sequence Note: This RefSeq record was created from transcripts of different strains and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5HUK6;P25388;P99049;Q5EVY1", "ec_number_list": "", "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0043022 ribosome binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0007165 signal transduction;GO:0032880 regulation of protein localization;GO:0016567 protein ubiquitination;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P63247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P63270-1", "uniprot_id": "ACTH_CHICK", "mass": 41877.0, "length": 376, "protein_name": "Actin, gamma-enteric smooth muscle", "gene_name": "ACTG2", "organism": "Chicken", "refseq_name": "actin, gamma-enteric smooth muscle", "refseq_ac": "NP_990503", "gene_names_uniprotkb": "ACTG2; ACTA3; ACTSG", "gene_names_refseq": "ACTA3; ACTG2; ACTSG; GAMMA-ACTIN", "protein_names_uniprotkb": "Actin, gamma-enteric smooth muscle; 3.6.4.-; Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin", "protein_names_refseq": "actin, gamma-enteric smooth muscle; alpha-actin-3; gamma-2-actin; smooth muscle gamma-actin", "tax_id": 9031, "disease": "", "pathway": " (gga:396084); (R-GGA-445355); (R-GGA-9764561); (R-GGA-9958825)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8319268", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01002403.1, S63494.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000333.1., [RefSeq]; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O73680;P12718", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;2.3.2.27;3.6.5.-;3.6.5.2;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.26;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0071944 cell periphery", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P67964-1", "uniprot_id": "VEGFA_CHICK", "mass": 25203.0, "length": 216, "protein_name": "Vascular endothelial growth factor A", "gene_name": "VEGFA", "organism": "Chicken", "refseq_name": "vascular endothelial growth factor A isoform 2 precursor", "refseq_ac": "NP_001103825", "gene_names_uniprotkb": "VEGFA; VEGF", "gene_names_refseq": "VEGFA; VEGF", "protein_names_uniprotkb": "Vascular endothelial growth factor A; VEGF-A; VPF; Vascular permeability factor", "protein_names_refseq": "VEGF-A; VPF; vascular endothelial growth factor A isoform 2 precursor; vascular permeability factor", "tax_id": 9031, "disease": "", "pathway": " (gga:395909)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12788823;15108306;16672338;26367766;26865366;27852059;30602288", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY168004.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992393, SAMEA103992428 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1. Transcript Variant: This variant (2) is lacking an in-frame, coding exon compared to transcript variant 1, resulting in a shorter isoform (2) that is missing a 24 aa segment, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Avian leukosis virus subgroup J induces VEGF expression via NF-kappaB/PI3K-dependent IL-6 production to promoter tumorigenesis., [RefSeq, PubMed]; BFGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons. Publication Status: Online-Only, [RefSeq, PubMed]; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity)., [UniProtKB, UniProtKB]; The VEGF and VEGFR-2 genes play critical roles in feather maturity. In addition, VEGFR-2 exon10-A69G and genotype EF in the Princess chicken could potentially be utilised as genetic markers to improve efficiency in breeding., [RefSeq, PubMed]; VEGF regulates interaction of pericytes and endothelial cells during vasculogenesis and experimental angiogenesis, [RefSeq, PubMed]; VEGF signals increases progenitor cell proliferation and decreases retinal ganglion cell genesis, [RefSeq, PubMed]; VEGF upregulates heme oxygenase-1 protein expression in vivo in chicken embryo chorioallantoic membranes by a mechanism dependent on an increase in cytosolic calcium levels and activation of protein kinase C., [RefSeq, PubMed]; VEGF-A protein was decreased in cadmium treated extraembryonic membranes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P52582;Q91420", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0045766 positive regulation of angiogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0051781 positive regulation of cell division;GO:0051894 positive regulation of focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P67964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P68034-1", "uniprot_id": "ACTC_CHICK", "mass": 42019.0, "length": 377, "protein_name": "Actin, alpha cardiac muscle 1", "gene_name": "ACTC1", "organism": "Chicken", "refseq_name": "actin, alpha cardiac muscle 1", "refseq_ac": "NP_001072949", "gene_names_uniprotkb": "ACTC1; ACTC", "gene_names_refseq": "ACTC1; ACTC", "protein_names_uniprotkb": "Actin, alpha cardiac muscle 1; 3.6.4.-; Alpha-cardiac actin", "protein_names_refseq": "actin, alpha cardiac muscle 1; alpha-cardiac actin", "tax_id": 9031, "disease": "", "pathway": " (gga:423298)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2998938;3855241", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01014447.1, HAEL01003980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1. On Dec 9, 2006 this sequence version replaced XP_421217.2., [RefSeq]; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04270", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0017022 myosin binding", "go_cellular_component": "GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0030017 sarcomere", "go_biological_process": "GO:0007015 actin filament organization;GO:0060047 heart contraction;GO:0033275 actin-myosin filament sliding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P68034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79761-1", "uniprot_id": "CP1A5_CHICK", "mass": 60071.0, "length": 528, "protein_name": "Cytochrome P450 1A5", "gene_name": "CYP1A5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CYP1A5", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 1A5; 1.14.14.1; CYPIA5; Cytochrome P450 TCDDAA", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396051)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8955152", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.14.-;1.14.14.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0006805 xenobiotic metabolic process;GO:0046677 response to antibiotic;GO:0042178 xenobiotic catabolic process;GO:0009404 toxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79761-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79762-1", "uniprot_id": "ZP3_CHICK", "mass": 46766.0, "length": 437, "protein_name": "Zona pellucida sperm-binding protein 3", "gene_name": "ZP3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ZP3; ZPC", "gene_names_refseq": "", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 3; Sperm receptor; Zona pellucida C protein; Zona pellucida glycoprotein 3; Zp-3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:378906)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10103002;15115720;16283938;20970175", "class_list": "", "function": "Component of the zona pellucida, which mediates species-specific sperm binding. Directly binds to sperm. Important for egg fertilization., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4VU46;Q4VU49;Q4VU50;Q4VU53;Q4VU54;Q4VU57;Q4VU62;Q4VU63;Q4VU66;Q9PWF8", "ec_number_list": "", "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0035805 egg coat", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0035803 egg coat formation;GO:0007339 binding of sperm to zona pellucida;GO:0032570 response to progesterone;GO:0033574 response to testosterone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P79762-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79774-1", "uniprot_id": "SNAT_CHICK", "mass": 23187.0, "length": 205, "protein_name": "Serotonin N-acetyltransferase", "gene_name": "AANAT", "organism": "Chicken", "refseq_name": "serotonin N-acetyltransferase", "refseq_ac": "NP_990489", "gene_names_uniprotkb": "AANAT; SNAT", "gene_names_refseq": "AANAT; SNAT; serotonin-N-acetyltransferase", "protein_names_uniprotkb": "Serotonin N-acetyltransferase; 2.3.1.87; AA-NAT; Aralkylamine N-acetyltransferase; Serotonin acetylase", "protein_names_refseq": "AA-NAT; arylalkylamine N-acetyltransferase; serotonin N-acetyltransferase; serotonin acetylase", "tax_id": 9031, "disease": "", "pathway": " (gga:396066); (R-GGA-209931)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16679554;20345751;21790603;22889436;30178274;37070273;8978728", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U46502.1, BI392408.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992470 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000316.1. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]., [RefSeq]; Arylalkylamine N-acetyltransferase (AANAT): Blue light induction, nuclear translocation, and potential role in the survival of chicken retina neuronal cells., [RefSeq, PubMed]; Catalyzes the N-acetylation of serotonin into N-acetylserotonin., [UniProtKB, UniProtKB]; The cyclic AMP-response element-like sequence and TTATT elements in the proximal promoter interact to mediate cAMP-dependent transcriptional regulation of Aanat, [RefSeq, PubMed]; The phase of the rhythms of retinal cBmal1 and cAANAT mRNAs suggests a link between retinal cBmal1 and cAANAT expressions similar to the regulation of pineal cAANAT transcription., [RefSeq, PubMed]; The results clearly demonstrate that the regulation of the diurnal increase in AA-NAT activity in retinal ganglion cells of chickens undergoes a different control mechanism from that observed in photoreceptors., [RefSeq, PubMed]; These results demonstrate for the first time that epinephrine can increase the synthesis of melatonin by increasing the transcription of AANAT., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.87", "go_molecular_function": "GO:0004060 arylamine N-acetyltransferase activity;GO:0004059 aralkylamine N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0007623 circadian rhythm;GO:0009416 response to light stimulus;GO:0030187 melatonin biosynthetic process;GO:0071492 cellular response to UV-A", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P79774-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79781-1", "uniprot_id": "RS27A_CHICK", "mass": 17979.0, "length": 156, "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "organism": "Chicken", "refseq_name": "ubiquitin-ribosomal protein eS31 fusion protein", "refseq_ac": "NP_001274134", "gene_names_uniprotkb": "RPS27A; UBA80", "gene_names_refseq": "RPS27A; UBA80", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eS31 fusion protein; 40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80", "protein_names_refseq": "40S ribosomal protein S27a; ubiquitin carboxyl extension protein 80; ubiquitin-40S ribosomal protein S27a; ubiquitin-ribosomal protein eS31 fusion protein; ubiquitin/ribosomal protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395796); (R-GGA-110312); (R-GGA-110314); (R-GGA-110320); (R-GGA-1169091); (R-GGA-1227882); (R-GGA-1227888); (R-GGA-1227892); (R-GGA-1234176); (R-GGA-1253288); (R-GGA-1295596); (R-GGA-1358803); (R-GGA-174048); (R-GGA-174084); (R-GGA-174113); (R-GGA-174154); (R-GGA-174178); (R-GGA-174184); (R-GGA-179409); (R-GGA-1799339); (R-GGA-182971); (R-GGA-187577); (R-GGA-195253); (R-GGA-201681); (R-GGA-205043); (R-GGA-209543); (R-GGA-209560); (R-GGA-2122948); (R-GGA-2173788); (R-GGA-2173791); (R-GGA-2173795); (R-GGA-2173796); (R-GGA-2467813); (R-GGA-2559582); (R-GGA-2672351); (R-GGA-3134975); (R-GGA-349425); (R-GGA-351465); (R-GGA-353299); (R-GGA-353303); (R-GGA-3769402); (R-GGA-382556); (R-GGA-433822); (R-GGA-433871); (R-GGA-434001); (R-GGA-434131); (R-GGA-437980); (R-GGA-437986); (R-GGA-450302); (R-GGA-450321); (R-GGA-450408); (R-GGA-4641257); (R-GGA-4641258); (R-GGA-4641263); (R-GGA-532668); (R-GGA-5357905); (R-GGA-5357956); (R-GGA-5358346); (R-GGA-5610780); (R-GGA-5610785); (R-GGA-5632684); (R-GGA-5654726); (R-GGA-5654727); (R-GGA-5654732); (R-GGA-5654733); (R-GGA-5655862); (R-GGA-5656121); (R-GGA-5656169); (R-GGA-5668541); (R-GGA-5675221); (R-GGA-5675482); (R-GGA-5684264); (R-GGA-5685942); (R-GGA-5687128); (R-GGA-5689603); (R-GGA-5689877); (R-GGA-5689880); (R-GGA-5689896); (R-GGA-5689901); (R-GGA-5693537); (R-GGA-5693565); (R-GGA-5696394); (R-GGA-5696395); (R-GGA-5696397); (R-GGA-5696400); (R-GGA-573298); (R-GGA-6781823); (R-GGA-6782135); (R-GGA-6782210); (R-GGA-6783310); (R-GGA-6804756); (R-GGA-6804757); (R-GGA-6804760); (R-GGA-6807004); (R-GGA-68867); (R-GGA-68949); (R-GGA-69017); (R-GGA-69231); (R-GGA-69541); (R-GGA-69601); (R-GGA-72706); (R-GGA-75815); (R-GGA-8849469); (R-GGA-8854050); (R-GGA-8856825); (R-GGA-8856828); (R-GGA-8863795); (R-GGA-8866427); (R-GGA-8866652); (R-GGA-8866654); (R-GGA-8939236); (R-GGA-8939902); (R-GGA-8941858); (R-GGA-8948747); (R-GGA-8948751); (R-GGA-8951664); (R-GGA-901032); (R-GGA-9013507); (R-GGA-9020702); (R-GGA-9033241); (R-GGA-909733); (R-GGA-912631); (R-GGA-917729); (R-GGA-936964); (R-GGA-937041); (R-GGA-937042); (R-GGA-937072); (R-GGA-9645460); (R-GGA-9646399); (R-GGA-9664873); (R-GGA-975163); (R-GGA-9755511); (R-GGA-9758274); (R-GGA-975956); (R-GGA-975957); (R-GGA-9762114); (R-GGA-9766229); (R-GGA-9770562); (R-GGA-9824878); (R-GGA-983168); (R-GGA-9861718); (R-GGA-9929356); (R-GGA-9929491); (R-GGA-9931269); (R-GGA-9931295); (R-GGA-9932298); (R-GGA-9954709); (R-GGA-9954714); (R-GGA-9954716); (R-GGA-9958810); (R-GGA-9958825)", "pathway_count": 151, "publication_count": 63, "publication_id_list": "10893229;11057907;11239454;11460167;12086603;12193592;12221085;12442171;12609980;12692549;12773817;13130464;14555995;14625308;14633987;15145317;15287722;15371334;15572677;15642098;15837794;16056267;16115877;16116421;16153868;16186825;16260493;16301747;16306937;16858409;16914100;17047224;17135271;17255097;17327220;17332413;17395714;17412408;17452773;17460694;17496917;17526488;1764072;17875933;17878161;18070982;18200010;18793328;18984593;19224918;19465916;19479062;19666475;19675569;19881509;19898473;20097753;8533096;8846784;9195981;9305777;9463386;9689078", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN237487.1, CO635634.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000059.1. On Jan 10, 2018 this sequence version replaced NP_990284.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Component of the 40S subunit of the ribosome. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; Ubiquitin Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P62973;Q29120;Q91887;Q91888", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006412 translation;GO:0019941 modification-dependent protein catabolic process;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "P79781-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79795-1", "uniprot_id": "NRP1_CHICK", "mass": 102480.0, "length": 914, "protein_name": "Neuropilin-1", "gene_name": "NRP1", "organism": "Chicken", "refseq_name": "neuropilin-1 precursor", "refseq_ac": "NP_990113", "gene_names_uniprotkb": "NRP1; NRP", "gene_names_refseq": "NRP1; neuropilin-1", "protein_names_uniprotkb": "Neuropilin-1; A5 protein", "protein_names_refseq": "A5 protein; neuropilin-1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395560)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16360650;16959234;18039974;21503876;25183873;25843547;7601310", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D45416.1, SRR13267655.55918.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D45416.1., [RefSeq]; Comparison of expression between mouse and chick embryos at early brain developmental stages., [RefSeq, PubMed]; Knockdown of Npr1 and Slit2 in chick embryos caused motor neurons to migrate to the periphery, [RefSeq, PubMed]; NRP1-mediated Sema3A signals provide repulsive signals for MAP2-positive neurons to segregate tectal layers, which is important in order to coordinate laminar organization of the optic tectum., [RefSeq, PubMed]; Post-transcriptional and local control of the availability of the Sema3A receptor neuropilin 1 at the growth cone surface, [RefSeq, PubMed]; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This study demonstrates that the environmental toxin, sodium arsenite, induced angiogenesis by altering the expression of miRNAs and their cognate mRNA targets., [RefSeq, PubMed]; With the reduction of neuropilin-1 function, neural crest cells still form segmental migratory streams, suggesting that initial neural crest cell migration and invasion of the branchial arches are separable processes, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:0017154 semaphorin receptor activity;GO:0005021 vascular endothelial growth factor receptor activity;GO:0038085 vascular endothelial growth factor binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030424 axon;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0048729 tissue morphogenesis;GO:0001570 vasculogenesis;GO:0007155 cell adhesion;GO:0010595 positive regulation of endothelial cell migration;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P79795-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P79987-1", "uniprot_id": "HIRA_CHICK", "mass": 112074.0, "length": 1019, "protein_name": "Protein HIRA", "gene_name": "HIRA", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HIRA; TUPLE1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein HIRA; TUP1-like enhancer of split protein 1; cHIRA", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374074)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14652010;15527972;16024922;16537536;9063744", "class_list": "", "function": "Cooperates with ASF1A to promote replication-independent chromatin assembly (By similarity). May regulate the transcription of a variety of genes controlling cell growth., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8JIE6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000417 HIR complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P79987-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80566-1", "uniprot_id": "SODC_CHICK", "mass": 15704.0, "length": 154, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "SOD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SOD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1; 1.8.-.-; Hydrogen sulfide oxidase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395938)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8647082;8988375", "class_list": "", "function": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the oxidation of hydrogen sulfide (H2S) to sulfate, playing an important role in detoxifying H2S and limiting the accumulation of reactive sulfur species (RSS) such as persulfides and polysulfides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q92059", "ec_number_list": "1.15.1.1;1.8.-.-", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P80566-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P84229-1", "uniprot_id": "H32_CHICK", "mass": 15388.0, "length": 136, "protein_name": "Histone H3.2", "gene_name": "H3-III; H3-II; H3-IV; H3-I; H3-VIII; H3-VII; H3-VI; H3-V", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H3-III; H3-II; H3-IV; H3-I; H3-VIII; H3-VII; H3-VI; H3-V", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H3.2; Histone H3 class I", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:100857439); (gga:100858681); (gga:417953); (gga:768333); (gga:769809); (gga:769852); (gga:770022); (R-GGA-1266695); (R-GGA-212300); (R-GGA-2559580); (R-GGA-3214847); (R-GGA-3247509); (R-GGA-427413); (R-GGA-5250924); (R-GGA-68616); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-983231); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 29, "publication_count": 11, "publication_id_list": "11092917;12123664;12876341;1874451;19102706;1946434;1956792;4000938;4859525;7078654;8804862", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02295;P02297;P16105;P17269;P17320", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P84229-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P87498-1", "uniprot_id": "VIT1_CHICK", "mass": 210630.0, "length": 1912, "protein_name": "Vitellogenin-1", "gene_name": "VTG1", "organism": "Chicken", "refseq_name": "vitellogenin-1 precursor", "refseq_ac": "NP_001004408", "gene_names_uniprotkb": "VTG1; VTGI", "gene_names_refseq": "LVII; TPRXL; VIT1; VTG1; YGP42; vitellogenin-1", "protein_names_uniprotkb": "Vitellogenin-1; LVII; LVI; Lipovitellin II; Lipovitellin I; Minor vitellogenin; Vitellogenin I", "protein_names_refseq": "minor vitellogenin; tetra-peptide repeat homeobox-like; vitellogenin I; vitellogenin-1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:424547)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20509661;26897338;7599159", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D89547.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000239.1. On Sep 23, 2021 this sequence version replaced NP_001004408.1., [RefSeq]; Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo., [UniProtKB]; Precursor of the egg-yolk proteins that are sources of nutrients during early development of oviparous organisms., [UniProtKB]; YGP42 protein, a fragment of the vitellogenin-1 precursor, is the second allergen characterized from egg yolk., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0045735 nutrient reservoir activity", "go_cellular_component": "", "go_biological_process": "GO:0032355 response to estradiol;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P87498-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98150-1", "uniprot_id": "NFKB2_CHICK", "mass": 99667.0, "length": 906, "protein_name": "Nuclear factor NF-kappa-B p100 subunit", "gene_name": "NFKB2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NFKB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; Lyt-10; Nuclear factor NF-kappa-B p50B subunit; Nuclear factor NF-kappa-B p97 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:386574)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11529676;7510259;8230480", "class_list": "", "function": "NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In concert with RELB, may play a role in the regulation of the circadian clock (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P98150-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98152-1", "uniprot_id": "TF65_CHICK", "mass": 60072.0, "length": 558, "protein_name": "Transcription factor p65", "gene_name": "RELA", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RELA", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396027); (R-GGA-1227892); (R-GGA-434001); (R-GGA-434131)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "11057907;12221085;15145317;15371334;16056267;16115877;16153868;17047224;17135271;17332413;17496917;18984593;19479062;19666475;20097753;7916720;9689078", "class_list": "", "function": "NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035525 NF-kappaB p50/p65 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P98152-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P98157-1", "uniprot_id": "LRP1_CHICK", "mass": 507133.0, "length": 4543, "protein_name": "Low-density lipoprotein receptor-related protein 1", "gene_name": "LRP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LRP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 1; A2MR; Alpha-2-macroglobulin receptor; LRP-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396170)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7506255;9790844", "class_list": "", "function": "Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 52, "predicted_n_glycosites": 50, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 52, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016964 alpha-2 macroglobulin receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P98157-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00649-1", "uniprot_id": "HSPB1_CHICK", "mass": 21672.0, "length": 193, "protein_name": "Heat shock protein beta-1", "gene_name": "HSPB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSPB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock protein beta-1; 25 kDa IAP; Actin polymerization inhibitor; HSP 25; HSP 27; Heat shock 25 kDa protein; Heat shock 27 kDa protein; HspB1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396227)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2071672", "class_list": "", "function": "Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0005080 protein kinase C binding;GO:0008426 protein kinase C inhibitor activity", "go_cellular_component": "GO:0005622 intracellular anatomical structure;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005819 spindle", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006469 negative regulation of protein kinase activity;GO:0051016 barbed-end actin filament capping;GO:0071901 negative regulation of protein serine/threonine kinase activity;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q00649-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00709-1", "uniprot_id": "BCL2_CHICK", "mass": 25687.0, "length": 233, "protein_name": "Apoptosis regulator Bcl-2", "gene_name": "BCL2", "organism": "Chicken", "refseq_name": "apoptosis regulator Bcl-2", "refseq_ac": "NP_990670", "gene_names_uniprotkb": "BCL2; BCL-2", "gene_names_refseq": "BCL-2; BCL2; PCKBCL2", "protein_names_uniprotkb": "Apoptosis regulator Bcl-2", "protein_names_refseq": "B-cell CLL/lymphoma 2; apoptosis regulator Bcl-2", "tax_id": 9031, "disease": "", "pathway": " (gga:396282); (R-GGA-111453); (R-GGA-844455)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1508712;1511008;23296903;24351749;28258011;31021056", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Z11961.1, SRR13267656.25735.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000040.1, BI066990.1, Z11961.1, BU490239.1, BI065826.1, DN853066.1, CN778444.1, BM490106.1, DR429213.1, CD730228.1, HAEK01056555.1, CR387315.1 and HAEK01100478.1. On Feb 20, 2015 this sequence version replaced NP_990670.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors., [RefSeq, PubMed]; Data suggest that lymphocyte apoptosis in the cecal tonsil of broilers was mediated by direct effects of fluoride on the expression of Bcl-2, Bax, and caspase-3: [bax], [RefSeq, PubMed]; MRNA expression was higher in Bax and Caspase-3, and lower in Bcl-2 of the 300, 600 and 900 mg/kg groups. SOD, CAT and GSH-Px activities, ability to inhibit hydroxyl radical, and GSH contents were decreased, and MDA contents were increased in all groups. Publication Status: Online-Only, [RefSeq, PubMed]; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)., [UniProtKB]; These findings have provided a novel mechanism whereby miR-16 represses Bcl2 and FOXO1 expression to maintain myoblast growth and skeletal muscle mass., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0035094 response to nicotine;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0051607 defense response to virus;GO:0051881 regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q00709-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01795-1", "uniprot_id": "MYF6_CHICK", "mass": 26351.0, "length": 242, "protein_name": "Myogenic factor 6", "gene_name": "MYF6", "organism": "Chicken", "refseq_name": "myogenic factor 6", "refseq_ac": "NP_001025917", "gene_names_uniprotkb": "MYF6; MRF4", "gene_names_refseq": "MRF4; MYF6; cMRF4", "protein_names_uniprotkb": "Myogenic factor 6; Muscle-specific regulatory factor 4; Myf-6", "protein_names_refseq": "herculin homolog; muscle-specific regulatory factor 4; myogenic factor 6 (herculin); myogenic factor 6", "tax_id": 9031, "disease": "", "pathway": " (gga:417873); (R-GGA-525793)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1374396;18244905;23054870", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01003030.1, FJ882409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On or before Dec 10, 2020 this sequence version replaced XP_015137402.2, XP_416115.1., [RefSeq]; Data suggest that selenium (Se; a dietary factor) promotes differentiation of embryonic myoblasts; up-regulation of selenoprotein W (SelW) and up-regulation of myogenic regulatory factors (MRF4/MYF6; MRF5; myogenin) upon Se treatment are correlated., [RefSeq, PubMed]; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein., [UniProtKB]; The wild-type allele A of Myf6 gene had significant positive effects on live-weight, carcass-weight, breast-muscle-weight and leg-muscle-weight (P<0.05), but had negative effects on most of meat quality traits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035914 skeletal muscle cell differentiation;GO:0048743 positive regulation of skeletal muscle fiber development;GO:0045663 positive regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q01795-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01841-1", "uniprot_id": "TGM2_CHICK", "mass": 77970.0, "length": 689, "protein_name": "Protein-glutamine gamma-glutamyltransferase 2", "gene_name": "TGM2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TGM2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 2; 2.3.1.-; 2.3.2.13; 3.4.-.-; 3.5.1.44; Erythrocyte transglutaminase; Isopeptidase TGM2; Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; TGase-2; Tissue transglutaminase; Transglutaminase-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396432)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1357669", "class_list": "", "function": "Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins: under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, resulting in the formation of scaffolds. Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components. In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (By similarity). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3. Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription. Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate. May also act as an isopeptidase cleaving the previously formed cross-links. Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.13;3.5.1.44;3.4.-.-;2.3.1.-", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0051260 protein homooligomerization;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q01841-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02020-1", "uniprot_id": "FIBB_CHICK", "mass": 52678.0, "length": 463, "protein_name": "Fibrinogen beta chain", "gene_name": "FGB", "organism": "Chicken", "refseq_name": "fibrinogen beta chain precursor", "refseq_ac": "NP_001161155", "gene_names_uniprotkb": "FGB", "gene_names_refseq": "FGB; fibrinogen", "protein_names_uniprotkb": "Fibrinogen beta chain", "protein_names_refseq": "beta-fibrinogen; fibrinogen beta chain precursor; fibrinogen, B beta polypeptide", "tax_id": 9031, "disease": "", "pathway": " (gga:373926)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10737772;11601975;2009266", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M58514.1, SRR12888530.105074.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1. On Nov 17, 2009 this sequence version replaced XP_420369.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005577 fibrinogen complex", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0070527 platelet aggregation;GO:0051258 protein polymerization;GO:0072378 blood coagulation, fibrin clot formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02020-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02092-1", "uniprot_id": "GHR_CHICK", "mass": 68573.0, "length": 608, "protein_name": "Growth hormone receptor", "gene_name": "GHR", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GHR", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth hormone receptor; GH receptor; Serum-binding protein; Somatotropin receptor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:408184)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10082631;11997231;2036984;8114754", "class_list": "", "function": "Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (By similarity). On ligand binding, couples to the JAK2/STAT5 pathway (PubMed:11997231)., [UniProtKB, PubMed, UniProtKB]; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6LDA0", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0019955 cytokine binding;GO:0004903 growth hormone receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0009897 external side of plasma membrane;GO:0070195 growth hormone receptor complex", "go_biological_process": "GO:0006897 endocytosis;GO:0008284 positive regulation of cell population proliferation;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0019221 cytokine-mediated signaling pathway;GO:0060396 growth hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03669-1", "uniprot_id": "AT2A2_CHICK", "mass": 114692.0, "length": 1041, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "gene_name": "ATP2A2", "organism": "Chicken", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 1", "refseq_ac": "NP_001258902", "gene_names_uniprotkb": "ATP2A2", "gene_names_refseq": "ATP2A2; SERCA2", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; 7.2.2.10; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; SERCA2; SR Ca(2+)-ATPase 2", "protein_names_refseq": "ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; SR Ca(2+)-ATPase 2; calcium pump 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform 1; sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396446)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1831452", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.307383.1, SRR13267658.4518.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1. On or before Dec 19, 2012 this sequence version replaced XP_415130.2, XP_003642224.1. Sequence Note:., [RefSeq]; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. May act as a regulator of TNFSF11-mediated Ca(2+) signaling during osteoclastogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.2.2.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity;GO:0086039 P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential", "go_cellular_component": "GO:0016020 membrane;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q03669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04619-1", "uniprot_id": "HS90B_CHICK", "mass": 83427.0, "length": 725, "protein_name": "Heat shock cognate protein HSP 90-beta", "gene_name": "HSP90AB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSP90AB1; HSPC3; HSPCB", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock cognate protein HSP 90-beta", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396188)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16879355;7916597", "class_list": "", "function": "Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046983 protein dimerization activity;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0034605 cellular response to heat;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q04619-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04861-1", "uniprot_id": "NFKB1_CHICK", "mass": 107992.0, "length": 983, "protein_name": "Nuclear factor NF-kappa-B p105 subunit", "gene_name": "NFKB1", "organism": "Chicken", "refseq_name": "nuclear factor NF-kappa-B p105 subunit isoform a", "refseq_ac": "NP_990465", "gene_names_uniprotkb": "NFKB1", "gene_names_refseq": "NF-KB1; NFKB1", "protein_names_uniprotkb": "Nuclear factor NF-kappa-B p105 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1", "protein_names_refseq": "NF-kB p50 subunit; nuclear factor NF-kappa-B p105 subunit isoform a; nuclear factor NF-kappa-B p105 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)", "tax_id": 9031, "disease": "", "pathway": " (gga:396033); (R-GGA-1227892); (R-GGA-434001); (R-GGA-434131)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "11057907;12221085;15145317;1533881;15371334;15592404;16056267;16115877;16153868;17047224;17135271;17332413;17496917;18984593;19005168;19479062;19666475;20097753;26872625;30672726;31398034;7916720;9233775;9689078", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D13719.1, SRR13267659.70151.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Oct 17, 2021 this sequence version replaced NP_990465.1., [RefSeq]; Constitutes the active form, which associates with RELA/p65 to form the NF-kappa-B p65-p50 complex to form a transcription factor. Together with RELA/p65, binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions., [UniProtKB, UniProtKB]; EGF stimulated proliferation of chicken PGCs via activation of Ca(2+)/PKC involving NFKB1 signaling pathway., [RefSeq, PubMed]; Mitochondrial localization of PB1-F2 resulted in reduced antagonism of an NFkappaB-dependent promoter., [RefSeq, PubMed]; P105 is the precursor of the active p50 subunit (Nuclear factor NF-kappa-B p50 subunit) of the nuclear factor NF-kappa-B. The precursor protein itself does not bind to DNA. Acts as a cytoplasmic retention of attached NF-kappa-B proteins by p105., [UniProtKB, UniProtKB]; RNA sequencing results revealed that the chicken NFKB1 was differently expressed between the intestinal mucosal layer of Necrotic enteritis induced chicken lines that are resistant and sensitive to avian leukosis and Marek's disease., [RefSeq, PubMed]; SNP g.32828A>G of RB1 is an obesity-associated variant that directly affects binding with NF-KB and SOX2, leading to changes in RB1 expression which in turn may influence chicken abdominal fat deposition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1C613;F1NU28;O13075", "ec_number_list": "", "go_molecular_function": "GO:0051059 NF-kappaB binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005737 cytoplasm;GO:0035525 NF-kappaB p50/p65 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q04861-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04929-1", "uniprot_id": "CRK_CHICK", "mass": 33806.0, "length": 305, "protein_name": "Adapter molecule crk", "gene_name": "CRK", "organism": "Chicken", "refseq_name": "adapter molecule crk", "refseq_ac": "NP_001340868", "gene_names_uniprotkb": "CRK", "gene_names_refseq": "CRK; P38C-CRK; p38", "protein_names_uniprotkb": "Adapter molecule crk; Proto-oncogene c-Crk; p38", "protein_names_refseq": "adapter molecule crk; proto-oncogene C-crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:107054794); (R-GGA-170984); (R-GGA-186763); (R-GGA-2029482); (R-GGA-372708); (R-GGA-4420097); (R-GGA-8849471); (R-GGA-8875555); (R-GGA-8875656); (R-GGA-912631)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "1329926;17304244;21131971;24571054;25284755", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.190476.1, SRR12888486.453133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On Aug 1, 2017 this sequence version replaced XP_015151517.1., [RefSeq]; Data indicate that human proto-oncogene c-CrkII (CrkII) is regulated by phosphorylation only, but chicken CrkII is regulated by Pro238 trans-->cis isomerization and by Tyr222 phosphorylation., [RefSeq, PubMed]; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility (By similarity). Involved in cell branching and adhesion (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These data suggest that Dock180/ELMO and CrkII act as two evolutionarily conserved signaling submodules that coordinately regulate engulfment., [RefSeq, PubMed]; This study analyzed the kinetics of folding and substrate binding of the two homologues and found that cis-trans isomerization of Pro238 determines target binding in chicken but not in human CT10 regulator of kinase protein (c-CrkII)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding;GO:0042169 SH2 domain binding;GO:0030971 receptor tyrosine kinase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization;GO:0048013 ephrin receptor signaling pathway;GO:0030036 actin cytoskeleton organization;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04982-2", "uniprot_id": "BRAF_CHICK", "mass": 84756.0, "length": 766, "protein_name": "Serine/threonine-protein kinase B-raf", "gene_name": "BRAF", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase B-raf isoform 2", "refseq_ac": "NP_990633", "gene_names_uniprotkb": "BRAF; RMIL", "gene_names_refseq": "BRAF; C-RMIL; RMIL", "protein_names_uniprotkb": "Serine/threonine-protein kinase B-raf; 2.7.11.1; Proto-oncogene B-Raf; Proto-oncogene c-Rmil; Serine/threonine-protein kinase Rmil", "protein_names_refseq": "B-Raf proto-oncogene serine/threonine-protein kinase; proto-oncogene B-Raf; proto-oncogene c-Rmil; rmil serine/threonine-protein kinase; serine/threonine kinase; serine/threonine-protein kinase B-raf isoform 2; serine/threonine-protein kinase B-raf; serine/threonine-protein kinase Rmil; v-raf murine sarcoma viral oncogene homolog B1", "tax_id": 9031, "disease": "", "pathway": " (gga:396239)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12411479;14654779;15592404;16702958;21203559;8323553", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X67052.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; BRAF alternative splicing is differentially regulated in avian, rodent and primates. Exon 9b is present in vertebrates but exon 8b is present only in eutherians. Publication Status: Online-Only, [RefSeq, PubMed]; Inducible gene deletion of the c-Rmil/B-raf gene in chicken DT40 B cells revealed that B-Raf is required for the maintenance of basal ERK activity as well as for a rapid and sustained ERK activation following B cell antigen receptor (BCR) activation., [RefSeq, PubMed]; Neutralizing mutations of D447/8, S446 & S447, or uncoupling of B-Raf from Ras-GTP, reduce chicken B-Raf actvity in PC12 differentiation. S365 is a 14-3-3 binding site. B-Raf(V600E) cannot be inhibited by blocking S446 phosphorylation or Ras activation., [RefSeq, PubMed]; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PGI2;Q8AV85", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04982-2", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05063-1", "uniprot_id": "LYOX_CHICK", "mass": 48153.0, "length": 420, "protein_name": "Protein-lysine 6-oxidase", "gene_name": "LOX", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOX", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein-lysine 6-oxidase; 1.4.3.13; Lysyl oxidase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396474)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1360009", "class_list": "", "function": "In addition to cross linking of extracellular matrix proteins, it may have a direct role in tumor suppression., [UniProtKB]; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.4.3.13", "go_molecular_function": "GO:0005518 collagen binding;GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0035791 platelet-derived growth factor receptor-beta signaling pathway;GO:0018057 peptidyl-lysine oxidation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05063-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05438-1", "uniprot_id": "BMR1B_CHICK", "mass": 56766.0, "length": 502, "protein_name": "Bone morphogenetic protein receptor type-1B", "gene_name": "BMPR1B", "organism": "Chicken", "refseq_name": "bone morphogenetic protein receptor type-1B precursor", "refseq_ac": "NP_990463", "gene_names_uniprotkb": "BMPR1B", "gene_names_refseq": "BMPR1B; RPK-1", "protein_names_uniprotkb": "Bone morphogenetic protein receptor type-1B; 2.7.11.30; ALK-6; Activin receptor-like kinase 6; BMP type-1B receptor; BMPR-1B; RPK-1; SKR6; Serine/threonine-protein kinase receptor R6", "protein_names_refseq": "ALK-6; BMP type-1B receptor; BMPR-1B; SKR6; activin receptor-like kinase 6; bone morphogenetic protein receptor type-1B precursor; bone morphogenetic protein receptor, type IB; receptor protein kinase; serine/threonine-protein kinase receptor R6", "tax_id": 9031, "disease": "", "pathway": " (gga:396030)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14523231;15804571;23250207;24129431;28359351;8400359", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D13432.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Dec 3, 2021 this sequence version replaced NP_990463.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; BMP signaling via Bmpr1a and Bmpr1b, is sufficient to modify nuclear organization in the chick diencephalon, [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcription (By similarity). Positively regulates chondrocyte differentiation (PubMed:14523231, PubMed:24129431)., [UniProtKB, PubMed, UniProtKB]; The finding that retinal gene expression for BMP2, 4, 7 and their receptors are not affected by short-term optical defocus contrasts with previous observations of sign-dependent expression changes for the same genes in the RPE., [RefSeq, PubMed]; Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.30", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005025 transforming growth factor beta receptor activity, type I", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0001501 skeletal system development;GO:0045597 positive regulation of cell differentiation;GO:0071363 cellular response to growth factor stimulus;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05744-1", "uniprot_id": "CATD_CHICK", "mass": 43298.0, "length": 398, "protein_name": "Cathepsin D", "gene_name": "CTSD", "organism": "Chicken", "refseq_name": "cathepsin D precursor", "refseq_ac": "NP_990508", "gene_names_uniprotkb": "CTSD", "gene_names_refseq": "CTSD", "protein_names_uniprotkb": "Cathepsin D; 3.4.23.5", "protein_names_refseq": "cathepsin D (lysosomal aspartyl peptidase); cathepsin D (lysosomal aspartyl protease); cathepsin D precursor; prepro-cathepsin D, prepro-CD", "tax_id": 9031, "disease": "", "pathway": " (gga:396090); (R-GGA-1442490); (R-GGA-2022377); (R-GGA-2132295); (R-GGA-6798695); (R-GGA-77387)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "1418623;16987511;22912465;23431385", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: S49650.1, SRR13267659.42546.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000214.1., [RefSeq]; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL., [UniProtKB]; Analysis of Gremlin-/- and Dkk-/- mouse mutants and local treatments with BMP proteins reveal that the expression of cathepsin B and D genes is regulated by BMP signaling, [RefSeq, PubMed]; Chicken CTSD variants are associated with egg quality traits., [RefSeq, PubMed]; Further studies are needed to assess whether 'similar to nothepsin' assists cathepsin D in the proteolytic processing of egg yolk proteins during follicular growth., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.186;2.7.11.24;1.11.1.24;3.4.21.4;2.3.3.8;3.2.1.31;3.1.3.48;4.1.2.13;3.4.19.9;3.2.1.166;3.4.22.52;3.6.4.13;3.5.1.3;3.4.14.1;2.3.2.5;5.3.1.9;1.8.3.2;3.4.22.1;3.4.22.42;2.7.1.1;3.3.2.6;4.2.99.18;5.6.2.4;2.7.1.35;2.3.2.27;3.6.4.6;4.1.2.4;2.7.10.2;3.4.24.35;5.2.1.8;3.2.1.23;2.4.1.1;5.4.2.11;5.4.2.4;3.5.4.5;2.7.1.40;3.4.24.56;3.6.5.2;3.4.21.41;1.1.1.42;2.4.1.25;3.2.1.33;3.1.1.47;2.7.1.11;1.11.1.6;1.13.11.34;3.4.19.1;3.4.23.34;5.3.2.1;5.3.3.12;3.4.23.15;1.4.3.-;4.2.1.24;3.6.1.6;3.4.24.7;3.5.4.6;3.1.6.14;5.4.2.2;2.7.4.6;3.2.1.17;1.16.3.1;3.4.23.5;5.3.99.2;3.6.5.-;3.5.1.23", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031904 endosome lumen;GO:0045121 membrane raft;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0097194 execution phase of apoptosis;GO:0060561 apoptotic process involved in morphogenesis;GO:0042159 lipoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q05744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05876-1", "uniprot_id": "FYN_CHICK", "mass": 60265.0, "length": 534, "protein_name": "Tyrosine-protein kinase Fyn", "gene_name": "FYN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FYN", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase Fyn; 2.7.10.2; Proto-oncogene c-Fyn; p59-Fyn", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "7496631;8455940", "class_list": "", "function": "Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0045121 membrane raft", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0030154 cell differentiation;GO:0030900 forebrain development;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q05876-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05917-1", "uniprot_id": "HME2_CHICK", "mass": 30507.0, "length": 289, "protein_name": "Homeobox protein engrailed-2", "gene_name": "EN2", "organism": "Chicken", "refseq_name": "homeobox protein engrailed-2", "refseq_ac": "NP_001254648", "gene_names_uniprotkb": "EN2; EN-2", "gene_names_refseq": "EN2; En-2; Gg-En-2", "protein_names_uniprotkb": "Homeobox protein engrailed-2; Gg-En-2; Homeobox protein en-2", "protein_names_refseq": "engrailed protein; homeobox protein en-2; homeobox protein engrailed-2", "tax_id": 9031, "disease": "", "pathway": " (gga:100859435)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1363401;24803658", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888515.71575.1, SRR12888497.664255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000036.1. On Jun 16, 2012 this sequence version replaced XP_003640724.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; A potential role of En2 in regulating cell migration and positioning in the tectal laminar formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0001650 fibrillar center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043524 negative regulation of neuron apoptotic process;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q05917-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06066-1", "uniprot_id": "YBOX1_CHICK", "mass": 35799.0, "length": 321, "protein_name": "Y-box-binding protein 1", "gene_name": "YBX1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "YBX1; YB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Y-box-binding protein 1; Y-box transcription factor; YB-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "16879355;25860507;8321222", "class_list": "", "function": "DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing and transcription regulation (PubMed:8321222). Binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and preventing mRNA decay (By similarity). Plays a role in the maternal-to-zygotic transition in early embryo by binding to m5C-containing maternal mRNAs and preventing their degradation (By similarity). Also promotes maternal-to-zygotic transition in oocytes and embryos by promoting translation repression; molecular mechanisms governing translation repression are unknown (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (By similarity). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (By similarity). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (By similarity). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (By similarity). Also able to bind DNA and regulate transcription (PubMed:8321222). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3') (By similarity). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (By similarity). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (By similarity). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003676 nucleic acid binding;GO:0035198 miRNA binding;GO:0062153 C5-methylcytidine-containing RNA reader activity", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0000932 P-body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0048255 mRNA stabilization;GO:0008544 epidermis development;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q06066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07212-1", "uniprot_id": "THY1_CHICK", "mass": 18165.0, "length": 160, "protein_name": "Thy-1 membrane glycoprotein", "gene_name": "THY1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "THY1", "gene_names_refseq": "", "protein_names_uniprotkb": "Thy-1 membrane glycoprotein; Thy-1 antigen", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1359371", "class_list": "", "function": "May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0005096 GTPase activator activity;GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0030426 growth cone;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0006469 negative regulation of protein kinase activity;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07212-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07494-1", "uniprot_id": "EPHB1_CHICK", "mass": 109558.0, "length": 984, "protein_name": "Ephrin type-B receptor 1", "gene_name": "EPHB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EPHB1; CEK6", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-B receptor 1; 2.7.10.1; EK6; EPH-like kinase 6; Tyrosine-protein kinase receptor EPH-2; cEK6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8510926", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a role in axon guidance during nervous system development. May also play an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. More generally, may play a role in targeted cell migration and adhesion. Upon activation by ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005005 transmembrane-ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043235 receptor complex;GO:0031901 early endosome membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048013 ephrin receptor signaling pathway;GO:0046777 protein autophosphorylation;GO:0060996 dendritic spine development;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07494-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07496-1", "uniprot_id": "EPHA4_CHICK", "mass": 109483.0, "length": 986, "protein_name": "Ephrin type-A receptor 4", "gene_name": "EPHA4", "organism": "Chicken", "refseq_name": "ephrin type-A receptor 4 precursor", "refseq_ac": "NP_990112", "gene_names_uniprotkb": "EPHA4; CEK8", "gene_names_refseq": "EPHA4", "protein_names_uniprotkb": "Ephrin type-A receptor 4; 2.7.10.1; EK8; EPH-like kinase 8; cEK8", "protein_names_refseq": "Cek8; EK8; EPH-like kinase 8; ephrin type-A receptor 4 precursor; ephrin type-A receptor 4", "tax_id": 9031, "disease": "", "pathway": " (gga:395559)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17577206;18094260;24130906;8510926;8808406", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: D38174.1, SRR13267652.25909.1 [ECO:0000331] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved NMD candidate :: translation inferred from conservation ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. On Nov 29, 2021 this sequence version replaced XP_015132300.1., [RefSeq]; Misexpression of EphA4 and EphB2 in VIIIth nerve axons resulted in a significant shift of dorsoventral spacing between the axon tracts, suggesting a cell-autonomous role for the partitioning of projection areas along this axis. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (By similarity)., [UniProtKB, UniProtKB]; These results support a role for EphA4 in establishing tonotopic projections in the auditory system, and further suggest a general role for Eph family proteins in establishing topographic maps in the nervous system., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q90772", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0097161 DH domain binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031901 early endosome membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0043087 regulation of GTPase activity;GO:0048013 ephrin receptor signaling pathway;GO:0035282 segmentation;GO:0001756 somitogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07496-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07498-1", "uniprot_id": "EPHB3_CHICK", "mass": 109579.0, "length": 988, "protein_name": "Ephrin type-B receptor 3", "gene_name": "EPHB3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EPHB3; CEK10", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-B receptor 3; 2.7.10.1; EK10; EPH-like kinase 10; cEK10", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8510926", "class_list": "", "function": "Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. May control other aspects of development through regulation of cell migration and positioning (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0016477 cell migration;GO:0048013 ephrin receptor signaling pathway;GO:0022407 regulation of cell-cell adhesion;GO:0060996 dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07498-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07598-1", "uniprot_id": "SCP2_CHICK", "mass": 58691.0, "length": 547, "protein_name": "Sterol carrier protein 2", "gene_name": "SCP2", "organism": "Chicken", "refseq_name": "sterol carrier protein 2", "refseq_ac": "NP_001292129", "gene_names_uniprotkb": "SCP2", "gene_names_refseq": "NSL-TP; SCP-2; SCP-X; SCP2; SCPX", "protein_names_uniprotkb": "Sterol carrier protein 2; 2.3.1.155; 2.3.1.16; 2.3.1.176; Acetyl-CoA C-myristoyltransferase; NSL-TP; Non-specific lipid-transfer protein; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-2; SCP-X; SCP-chi; SCPX; Sterol carrier protein X", "protein_names_refseq": "SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-chi; acetyl-CoA C-myristoyltransferase; non-specific lipid-transfer protein; propanoyl-CoA C-acyltransferase; sterol carrier protein 2; sterol carrier protein X", "tax_id": 9031, "disease": "", "pathway": " (gga:396550)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8323294", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L09231.1, SRR12888533.133339.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1., [RefSeq]; Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (By similarity). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.176;2.3.1.16;2.3.1.155", "go_molecular_function": "GO:0033814 propanoyl-CoA C-acyltransferase activity;GO:0008289 lipid binding;GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0050633 acetyl-CoA C-myristoyltransferase activity;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0006869 lipid transport;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q07598-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07816-1", "uniprot_id": "B2CL1_CHICK", "mass": 25733.0, "length": 229, "protein_name": "Bcl-2-like protein 1", "gene_name": "BCL2L1", "organism": "Chicken", "refseq_name": "bcl-2-like protein 1", "refseq_ac": "NP_001020475", "gene_names_uniprotkb": "BCL2L1; BCL-X; BCLX", "gene_names_refseq": "BCL2L1; BCL2L; BCLX; Bcl-xl; bcl-x", "protein_names_uniprotkb": "Bcl-2-like protein 1; Apoptosis regulator Bcl-X; Bcl2-L-1", "protein_names_refseq": "apoptosis regulator Bcl-X; bcl-2-like protein 1; bcl2-L-1", "tax_id": 9031, "disease": "", "pathway": " (gga:373954); (R-GGA-111453); (R-GGA-844455)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "24351749;8358789;9110311", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U26645.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA3109053 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U26645.1. On Jul 13, 2005 this sequence version replaced XP_417450.1., [RefSeq]; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity)., [UniProtKB]; MRNA expression was higher in Bax and Caspase-3, and lower in Bcl-2 of the 300, 600 and 900 mg/kg groups. SOD, CAT and GSH-Px activities, ability to inhibit hydroxyl radical, and GSH contents were decreased, and MDA contents were increased in all groups. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q98908", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0015267 channel activity;GO:0051434 BH3 domain binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051607 defense response to virus;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0051881 regulation of mitochondrial membrane potential;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q07816-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08156-1", "uniprot_id": "KIT_CHICK", "mass": 107312.0, "length": 960, "protein_name": "Mast/stem cell growth factor receptor Kit", "gene_name": "KIT", "organism": "Chicken", "refseq_name": "mast/stem cell growth factor receptor Kit precursor", "refseq_ac": "NP_989692", "gene_names_uniprotkb": "KIT", "gene_names_refseq": "KIT; SCFR", "protein_names_uniprotkb": "Mast/stem cell growth factor receptor Kit; 2.7.10.1; Proto-oncogene c-Kit; SCFR; Tyrosine-protein kinase Kit", "protein_names_refseq": "c-kit; mast/stem cell growth factor receptor Kit precursor; mast/stem cell growth factor receptor Kit; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:378783); (R-GGA-1257604); (R-GGA-1433557); (R-GGA-1433559); (R-GGA-5673001); (R-GGA-6811558); (R-GGA-9856649)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "22912461;7685729", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D13225.1, SRR13267655.50918.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D13225.1., [RefSeq]; Study reveals the distribution of interstitial cells of Cajal, quantifies the expression of c-Kit mRNA in the intestine of adult chicken, and also compares the c-Kit-positive cell types morphologically, [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. KIT promotes activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;6.1.1.15;6.1.1.17;2.7.10.2;3.1.3.48;2.7.10.1;2.7.11.17;2.7.12.1;6.1.1.19;2.8.2.-;6.1.1.6;3.6.5.2;2.7.11.1;2.7.11.23;6.1.1.4;6.1.1.18;2.3.2.27;2.7.11.24;6.1.1.5;2.7.1.153;2.7.1.137;2.7.1.154;2.7.10.4", "go_molecular_function": "GO:0002020 protease binding;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0038093 Fc receptor signaling pathway;GO:0006954 inflammatory response;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08156-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q0GGW5-1", "uniprot_id": "STK11_CHICK", "mass": 49793.0, "length": 440, "protein_name": "Serine/threonine-protein kinase STK11", "gene_name": "STK11", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase STK11", "refseq_ac": "NP_001039298", "gene_names_uniprotkb": "STK11", "gene_names_refseq": "LKB1; STK11", "protein_names_uniprotkb": "Serine/threonine-protein kinase STK11; 2.7.11.1; LKB1; Liver kinase B1 homolog", "protein_names_refseq": "liver kinase B1 homolog; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11", "tax_id": 9031, "disease": "", "pathway": " (gga:420105)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16343965;27527806", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ864976.1, SRR13267648.19355.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ864976.1. On or before Sep 5, 2006 this sequence version replaced XP_418226.1, XP_418227.1., [RefSeq]; Silencing of the LKB1 tumor suppressor affects the delamination of pre-migratory cephalic neural crest cells from the neural primordium as well as their polarization and survival, thus resulting in severe facial and brain defects, [RefSeq, PubMed]; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006974 DNA damage response;GO:0032147 activation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0GGW5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q10751-1", "uniprot_id": "ACE_CHICK", "mass": 147239.0, "length": 1281, "protein_name": "Angiotensin-converting enzyme", "gene_name": "ACE", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ACE; DCP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiotensin-converting enzyme; 3.4.15.1; ACE; Dipeptidyl carboxypeptidase I; Kininase II", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:419953)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;7811282", "class_list": "", "function": "Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity (By similarity). Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates (By similarity). Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin (By similarity). Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response (By similarity). Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins (By similarity). Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) (By similarity). Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "F1NYM0;J7GZN9", "ec_number_list": "3.4.24.11;3.4.-.-;3.4.15.1", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0008241 peptidyl-dipeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0060319 primitive erythrocyte differentiation;GO:0008283 cell population proliferation;GO:0001822 kidney development;GO:0002003 angiotensin maturation;GO:0003084 positive regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q10751-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q1PRL4-1", "uniprot_id": "LIN41_CHICK", "mass": 94188.0, "length": 876, "protein_name": "E3 ubiquitin-protein ligase TRIM71", "gene_name": "TRIM71", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TRIM71; LIN41", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM71; 2.3.2.27; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:428445)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16245339;16247770;16477647", "class_list": "", "function": "E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2QDD9;Q3LAF8", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0035198 miRNA binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0010608 post-transcriptional regulation of gene expression;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0021915 neural tube development;GO:0000082 G1/S transition of mitotic cell cycle;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q1PRL4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2AB83-1", "uniprot_id": "T2R40_CHICK", "mass": 35281.0, "length": 311, "protein_name": "Taste receptor type 2 member 40", "gene_name": "TAS2R40", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TAS2R40; TAS2R1", "gene_names_refseq": "", "protein_names_uniprotkb": "Taste receptor type 2 member 40; T2R1; T2R40; Taste receptor type 2 member 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:101749182)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15592404;16484289;25796330;26049797;28811548", "class_list": "", "function": "Bitter taste receptor (PubMed:25796330). Binds quinine, dextromethorphan, diphenhydramine, diphenidol, chlorpheniramine, diphenidol, chloramphenicol, chloroquine and coumarin, this latter being a weak agonist, as well as epiquinidine, ethylhydrocupreine and quinidine (PubMed:28811548)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0X9UE61", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus;GO:0097237 cellular response to toxic substance;GO:0080184 response to phenylpropanoid;GO:0071316 cellular response to nicotine;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q2AB83-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q2VRL0-1", "uniprot_id": "PLCZ1_CHICK", "mass": 72533.0, "length": 637, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "gene_name": "PLCZ1", "organism": "Chicken", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "refseq_ac": "NP_001034362", "gene_names_uniprotkb": "PLCZ1", "gene_names_refseq": "PLCZ1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; 3.1.4.11; PLC-zeta-1; Phosphoinositide phospholipase C-zeta-1; Phospholipase C-zeta-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; phosphoinositide phospholipase C-zeta-1", "tax_id": 9031, "disease": "", "pathway": " (gga:418182); (R-GGA-1855204)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16049153;18448841", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY843531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Jan 31, 2006 this sequence version replaced XP_416413.1., [RefSeq]; The expression of chicken PLCZ1 transcript was strongly detected in the cytoplasm of secondary spermatocytes, round spermatids, and elongated spermatids at adult age., [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.11", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0060470 positive regulation of cytosolic calcium ion concentration involved in egg activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2VRL0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3V6R6-1", "uniprot_id": "CETP_CHICK", "mass": 56716.0, "length": 505, "protein_name": "Cholesteryl ester transfer protein", "gene_name": "CETP", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CETP", "gene_names_refseq": "", "protein_names_uniprotkb": "Cholesteryl ester transfer protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17574888", "class_list": "", "function": "Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:17574888). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005548 phospholipid transporter activity;GO:0015485 cholesterol binding;GO:0031210 phosphatidylcholine binding;GO:0017129 triglyceride binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0034374 low-density lipoprotein particle remodeling;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3V6R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4JIM4-1", "uniprot_id": "PSN1_CHICK", "mass": 52831.0, "length": 468, "protein_name": "Presenilin-1", "gene_name": "PSEN1", "organism": "Chicken", "refseq_name": "presenilin-1", "refseq_ac": "NP_989494", "gene_names_uniprotkb": "PSEN1", "gene_names_refseq": "PS-1; PSEN1; presenilin-1", "protein_names_uniprotkb": "Presenilin-1; 3.4.23.-; PS-1", "protein_names_refseq": "presenilin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:373977)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11987239;16046145;16430960", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY043492.1, ERR7564025.14731.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Jul 10, 2015 this sequence version replaced NP_989494.1., [RefSeq]; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins., [UniProtKB, UniProtKB]; Changes in the molecular composition of the N-cadherin complex (represented by the uncoupling of p120-catenin and association with PS1) may correspond to distinct functional states of the complex involved in synaptic maturation Erratum:[Mol Cell Neurosci. 2005 Dec;30(4):559], [RefSeq, PubMed]; The authors use expression of presenilin 1 to demonstrate that granulocytes complete functional maturation in gut, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90X08", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007155 cell adhesion;GO:0007219 Notch signaling pathway;GO:0016485 protein processing;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4JIM4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q4W5Z4-1", "uniprot_id": "DNM3A_CHICK", "mass": 98944.0, "length": 877, "protein_name": "DNA (cytosine-5)-methyltransferase 3A", "gene_name": "DNMT3A", "organism": "Chicken", "refseq_name": "DNA (cytosine-5)-methyltransferase 3A", "refseq_ac": "NP_001020003", "gene_names_uniprotkb": "DNMT3A", "gene_names_refseq": "DNMT3A", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 3A; 2.1.1.-; 2.1.1.37; Cysteine methyltransferase DNMT3A; Dnmt3a", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 3A; DNA methyltransferase 3A; cysteine methyltransferase DNMT3A", "tax_id": 9031, "disease": "", "pathway": " (gga:421991)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16575165;18648519;21559294;23124063;26826496", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB214886.1, LC381635.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000070.1. On Sep 23, 2021 this sequence version replaced NP_001020003.1., [RefSeq]; Analysis of expression patterns and miRNA regulation of DNA methyltransferases in chicken primordial germ cells Publication Status: Online-Only, [RefSeq, PubMed]; Analysis of the potential of epigenetic alterations in DNMT1 and DNMT3a, as well as the DNA mutations in DNMT3b, as epigenetic and genetic factors to neoplastic diseases of chickens Publication Status: Online-Only, [RefSeq, PubMed]; DNMT3A functions as a molecular switch, repressing neural to favor neural crest cell fate, [RefSeq, PubMed]; DNMT3A is important for enabling the activation of Gbx2 expression, necessary for normal development of the inner ear, [RefSeq, PubMed]; Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. Also has weak auto-methylation activity on some Cys residue in absence of DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.37;2.1.1.364;2.1.1.-", "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0008270 zinc ion binding;GO:0001046 core promoter sequence-specific DNA binding;GO:0106363 protein-cysteine methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0000791 euchromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0009408 response to heat;GO:0032259 methylation;GO:0071774 response to fibroblast growth factor", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4W5Z4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F356-1", "uniprot_id": "PI42A_CHICK", "mass": 46092.0, "length": 405, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha", "gene_name": "PIP4K2A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PIP4K2A; PIP5K2A; RCJMB04_33l24", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 2.7.1.149; Diphosphoinositide kinase 2-alpha; PI(5)P 4-kinase type II alpha; PIP4KII-alpha; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PtdIns(5)P-4-kinase isoform 2-alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420504)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.149", "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0090119 vesicle-mediated cholesterol transport;GO:0061909 autophagosome-lysosome fusion;GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F356-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F364-1", "uniprot_id": "MRP1_CHICK", "mass": 170972.0, "length": 1525, "protein_name": "Multidrug resistance-associated protein 1", "gene_name": "ABCC1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ABCC1; MRP1; RCJMB04_32d20", "gene_names_refseq": "", "protein_names_uniprotkb": "Multidrug resistance-associated protein 1; 7.6.2.2; 7.6.2.3; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; LTC4 transporter; Leukotriene C(4) transporter", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395416)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide and other xenobiotics. Hydrolyzes ATP with low efficiency. Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (By similarity). Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "7.6.2.2;7.6.2.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0046943 carboxylic acid transmembrane transporter activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0034775 glutathione transmembrane transport;GO:0042908 xenobiotic transport;GO:0070729 cyclic nucleotide transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F364-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F3L9-1", "uniprot_id": "RIPR2_CHICK", "mass": 66897.0, "length": 602, "protein_name": "Rho family-interacting cell polarization regulator 2", "gene_name": "RIPOR2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RIPOR2; FAM65B; MYONAP; RCJMB04_13m20", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho family-interacting cell polarization regulator 2; Myogenesis-related and NCAM-associated protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421003)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0016324 apical plasma membrane;GO:0030175 filopodium;GO:0032420 stereocilium", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F3W6-1", "uniprot_id": "1433G_CHICK", "mass": 28231.0, "length": 247, "protein_name": "14-3-3 protein gamma", "gene_name": "YWHAG", "organism": "Chicken", "refseq_name": "14-3-3 protein gamma", "refseq_ac": "NP_001026648", "gene_names_uniprotkb": "YWHAG; RCJMB04_5e12", "gene_names_refseq": "YWHAG", "protein_names_uniprotkb": "14-3-3 protein gamma", "protein_names_refseq": "14-3-3 protein gamma; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide", "tax_id": 9031, "disease": "", "pathway": " (gga:427820)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851534.1, SRR13267660.25754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1. On Sep 23, 2021 this sequence version replaced NP_001026648.1., [RefSeq]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0140031 phosphorylation-dependent protein binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F3X0-1", "uniprot_id": "LCLT1_CHICK", "mass": 44448.0, "length": 378, "protein_name": "Lysocardiolipin acyltransferase 1", "gene_name": "LCLAT1", "organism": "Chicken", "refseq_name": "lysocardiolipin acyltransferase 1", "refseq_ac": "NP_001026210", "gene_names_uniprotkb": "LCLAT1; AGPAT8; LYCAT; RCJMB04_5b22", "gene_names_refseq": "1-AGPAT 8; AGPAT8; LCLAT1; LYCAT", "protein_names_uniprotkb": "Lysocardiolipin acyltransferase 1; 1-AGP acyltransferase 8; 1-AGPAT 8; 1-acylglycerol-3-phosphate O-acyltransferase 8; 2.3.1.-; 2.3.1.51; Acyl-CoA:lysocardiolipin acyltransferase 1", "protein_names_refseq": "1-AGP acyltransferase 8; 1-acylglycerol-3-phosphate O-acyltransferase 8; acyl-CoA:lysocardiolipin acyltransferase 1; lysocardiolipin acyltransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:421303)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267652.8104.1, SRR13267655.117063.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000061.1. On or before Dec 9, 2020 this sequence version replaced XP_025004425.1, XP_419368.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (By similarity). Required for establishment of the hematopoietic and endothelial lineages (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.51;2.3.1.15;2.3.1.-;2.3.1.23;2.3.1.n7", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0036149 phosphatidylinositol acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3X0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F407-1", "uniprot_id": "MGT4A_CHICK", "mass": 61566.0, "length": 535, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "organism": "Chicken", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "refseq_ac": "NP_001012842", "gene_names_uniprotkb": "MGAT4A; RCJMB04_3o8", "gene_names_refseq": "MGAT4A", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; 2.4.1.145; GlcNAc-T IVa; GnT-IVa; N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa", "protein_names_refseq": "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; glcNAc-T IVa; gnT-IVa; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A", "tax_id": 9031, "disease": "", "pathway": " (gga:418692)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851493.1, HAEK01018957.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000025.1. On Sep 23, 2021 this sequence version replaced NP_001012842.1., [RefSeq]; Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.145", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0008453 alanine-glyoxylate transaminase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack", "go_biological_process": "GO:0046487 glyoxylate metabolic process;GO:0006487 protein N-linked glycosylation;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F407-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F425-1", "uniprot_id": "LIN7C_CHICK", "mass": 21847.0, "length": 197, "protein_name": "Protein lin-7 homolog C", "gene_name": "LIN7C", "organism": "Chicken", "refseq_name": "protein lin-7 homolog C", "refseq_ac": "NP_001026238", "gene_names_uniprotkb": "LIN7C; RCJMB04_3l24", "gene_names_refseq": "LIN7B; LIN7C", "protein_names_uniprotkb": "Protein lin-7 homolog C; Lin-7C", "protein_names_refseq": "lin-7 homolog B; lin-7C; protein lin-7 homolog C", "tax_id": 9031, "disease": "", "pathway": " (gga:421608)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888503.42323.1, SRR12888505.140711.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000212.1. On or before Dec 17, 2020 this sequence version replaced XP_015141655.2, XP_419646.1., [RefSeq]; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains (By similarity). The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane;GO:0045202 synapse;GO:0098793 presynapse;GO:0097025 MPP7-DLG1-LIN7 complex", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0048489 synaptic vesicle transport;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F425-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F468-1", "uniprot_id": "S38A2_CHICK", "mass": 55531.0, "length": 501, "protein_name": "Sodium-coupled neutral amino acid symporter 2", "gene_name": "SLC38A2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC38A2; RCJMB04_2k20; SNAT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid symporter 2; Amino acid transporter A2; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane. The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005298 proline:sodium symporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0015824 proline transport;GO:0032328 alanine transport;GO:1904271 L-proline import across plasma membrane;GO:0006865 amino acid transport;GO:0006868 glutamine transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F468-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F470-1", "uniprot_id": "RAB8A_CHICK", "mass": 23522.0, "length": 207, "protein_name": "Ras-related protein Rab-8A", "gene_name": "RAB8A", "organism": "Chicken", "refseq_name": "ras-related protein Rab-8A", "refseq_ac": "NP_001384253", "gene_names_uniprotkb": "RAB8A; RCJMB04_2k8", "gene_names_refseq": "RAB8A", "protein_names_uniprotkb": "Ras-related protein Rab-8A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-8A", "tax_id": 9031, "disease": "", "pathway": " (gga:428352)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.81309.1, SRR13267659.30860.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000376.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Regulates the compacted morphology of the Golgi. Together with MYO5B and RAB11A participates in epithelial cell polarization. Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy. Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route. Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation. Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0007409 axonogenesis;GO:0060271 cilium assembly;GO:0006887 exocytosis;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F470-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5F499-1", "uniprot_id": "OPA1_CHICK", "mass": 113446.0, "length": 977, "protein_name": "Dynamin-like GTPase OPA1, mitochondrial", "gene_name": "OPA1", "organism": "Chicken", "refseq_name": "dynamin-like GTPase OPA1, mitochondrial isoform 1 precursor", "refseq_ac": "NP_001034398", "gene_names_uniprotkb": "OPA1; RCJMB04_1m16", "gene_names_refseq": "OPA1", "protein_names_uniprotkb": "Dynamin-like GTPase OPA1, mitochondrial; 3.6.5.5; Optic atrophy protein 1 homolog", "protein_names_refseq": "dynamin-like 120 kDa protein, mitochondrial; dynamin-like GTPase OPA1, mitochondrial isoform 1 precursor; dynamin-like GTPase OPA1, mitochondrial; optic atrophy 1 (autosomal dominant); optic atrophy protein 1 homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:424900)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851401.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. On Oct 1, 2021 this sequence version replaced NP_001034398.1., [RefSeq]; Constitutes the soluble short form (S-OPA1) generated by cleavage by OMA1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (By similarity). The transmembrane long form (L-OPA1) and the S-OPA1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (By similarity). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (By similarity). Excess levels of S-OPA1 produced by cleavage by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, thereby inhibiting mitochondrial fusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (By similarity). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Constitutes the transmembrane long form (L-OPA1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (By similarity). L-OPA1 and the soluble short form (S-OPA1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (By similarity). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (By similarity). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (By similarity). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space (By similarity). Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane (By similarity). The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (By similarity). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity). Its role in mitochondrial morphology is required for mitochondrial genome maintenance (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005874 microtubule;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0097749 membrane tubulation;GO:0032740 positive regulation of interleukin-17 production;GO:0016559 peroxisome fission;GO:0006915 apoptotic process;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F499-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZI51-1", "uniprot_id": "ADPRS_CHICK", "mass": 39909.0, "length": 367, "protein_name": "ADP-ribosylhydrolase ARH3", "gene_name": "ADPRS", "organism": "Chicken", "refseq_name": "ADP-ribosylhydrolase ARH3", "refseq_ac": "NP_001006312", "gene_names_uniprotkb": "ADPRS; ADPRHL2; ARH3; RCJMB04_30e5", "gene_names_refseq": "ADPRHL2; ADPRS; ARH3", "protein_names_uniprotkb": "ADP-ribosylhydrolase ARH3; 3.2.1.143; 3.2.2.-; 3.5.1.-; ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 3; O-acetyl-ADP-ribose deacetylase ARH3; Poly(ADP-ribose) glycohydrolase ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase", "protein_names_refseq": "ADP-ribose glycohydrolase ARH3; ADP-ribosylhydrolase 3; ADP-ribosylhydrolase ARH3; O-acetyl-ADP-ribose deacetylase ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein 2; [Protein ADP-ribosylserine] hydrolase; poly(ADP-ribose) glycohydrolase ARH3", "tax_id": 9031, "disease": "", "pathway": " (gga:419626)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720933.1, ERR7564045.10999.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000339.1. On Sep 23, 2021 this sequence version replaced NP_001006312.1., [RefSeq]; ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (By similarity). Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.143;3.5.1.-;3.2.2.-", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0004649 poly(ADP-ribose) glycohydrolase activity;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140292 ADP-ribosylserine hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006281 DNA repair;GO:0060546 negative regulation of necroptotic process;GO:0071451 cellular response to superoxide;GO:0140290 peptidyl-serine ADP-deribosylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZI51-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZIA0-1", "uniprot_id": "MET16_CHICK", "mass": 63386.0, "length": 558, "protein_name": "RNA N(6)-adenosine-methyltransferase METTL16", "gene_name": "METTL16", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "METTL16; METT10D; RCJMB04_28o5", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA N(6)-adenosine-methyltransferase METTL16; 2.1.1.346; 2.1.1.348; Methyltransferase 10 domain-containing protein; Methyltransferase-like protein 16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:431184)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A splicing and protein expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.348;2.1.1.346", "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003723 RNA binding;GO:0035613 RNA stem-loop binding;GO:0030629 U6 snRNA 3'-end binding;GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0010608 post-transcriptional regulation of gene expression;GO:0006402 mRNA catabolic process;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZID6-3", "uniprot_id": "5NT3A_CHICK", "mass": 37370.0, "length": 331, "protein_name": "Cytosolic 5'-nucleotidase 3A", "gene_name": "NT5C3A", "organism": "Chicken", "refseq_name": "cytosolic 5'-nucleotidase 3A", "refseq_ac": "NP_989767", "gene_names_uniprotkb": "NT5C3A; NT5C3; PYN1; RCJMB04_27l2", "gene_names_refseq": "NT5C3A; NT5C3; PYN1", "protein_names_uniprotkb": "Cytosolic 5'-nucleotidase 3A; 3.1.3.5; 3.1.3.91; 7-methylguanosine nucleotidase; 7-methylguanosine phosphate-specific 5'-nucleotidase; Cytosolic 5'-nucleotidase 3; Cytosolic 5'-nucleotidase III; P5'N-1; P5N-1; PN-I; Pyrimidine 5'-nucleotidase 1; cN-III", "protein_names_refseq": "5'-nucleotidase, cytosolic III; 7-methylguanosine nucleotidase; 7-methylguanosine phosphate-specific 5'-nucleotidase; P5'N-1; P5N-1; PN-I; cN-III; cytosolic 5'-nucleotidase 3A; cytosolic 5'-nucleotidase 3; cytosolic 5'-nucleotidase III; pyrimidine 5'-nucleotidase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395080); (R-GGA-73621)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12907448;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF548635.1, AJ496195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1., [RefSeq]; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q802T3", "ec_number_list": "3.1.3.5;2.7.1.77;3.1.3.99;3.1.3.91", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0000166 nucleotide binding;GO:0008253 5'-nucleotidase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZID6-3", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZIN0-1", "uniprot_id": "ABD12_CHICK", "mass": 43855.0, "length": 381, "protein_name": "Lysophosphatidylserine lipase ABHD12", "gene_name": "ABHD12", "organism": "Chicken", "refseq_name": "lysophosphatidylserine lipase ABHD12", "refseq_ac": "NP_001012889", "gene_names_uniprotkb": "ABHD12; RCJMB04_24m17", "gene_names_refseq": "ABHD12", "protein_names_uniprotkb": "Lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; 3.1.-.-; 3.1.1.-; 3.1.1.23; Abhydrolase domain-containing protein 12; Monoacylglycerol lipase ABHD12; Oxidized phosphatidylserine lipase ABHD12", "protein_names_refseq": "2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain-containing protein 12; lysophosphatidylserine lipase ABHD12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12", "tax_id": 9031, "disease": "", "pathway": " (gga:421249)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720754.1, HAEK01017228.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000060.1. On Mar 14, 2005 this sequence version replaced XP_419320.1., [RefSeq]; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Prefers as substrates lysophosphatidylserines having long and very long chain acyl chains (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.23;3.1.1.79;3.1.4.38;3.5.1.1;3.1.1.47;3.1.1.5;3.1.1.4;3.1.1.3;3.5.1.99;3.1.1.32;3.3.2.9;3.1.1.6;3.1.1.-;3.1.-.-", "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0120560 phosphatidylserine lysophospholipase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0046464 acylglycerol catabolic process;GO:0052651 monoacylglycerol catabolic process;GO:0006660 phosphatidylserine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIN0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZIT5-1", "uniprot_id": "RAB10_CHICK", "mass": 22549.0, "length": 200, "protein_name": "Ras-related protein Rab-10", "gene_name": "RAB10", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RAB10; RCJMB04_23k10", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rab-10; 3.6.5.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421994)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB10 is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Also plays a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. Finally, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (By similarity). May participate in the export of neosynthesized proteins through a Rab-dependent endosomal export route (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0031489 myosin V binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0007409 axonogenesis;GO:0032869 cellular response to insulin stimulus;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIT5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZIZ4-1", "uniprot_id": "5NTC_CHICK", "mass": 65894.0, "length": 569, "protein_name": "Cytosolic purine 5'-nucleotidase", "gene_name": "NT5C2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NT5C2; RCJMB04_22h21", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytosolic purine 5'-nucleotidase; 2.7.1.77; 3.1.3.5; 3.1.3.99; Cytosolic nucleoside phosphotransferase 5'N", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423871); (R-GGA-421178)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15642098;6060459;7852355", "class_list": "", "function": "Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:6060459). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (By similarity). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP (PubMed:6060459). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (By similarity). Through these activities regulates the purine nucleoside/nucleotide pools within the cell (PubMed:6060459)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.5;3.1.4.1;3.6.1.9;2.7.1.77;3.1.3.99;3.1.3.91", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0050146 nucleoside phosphotransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046054 dGMP metabolic process;GO:0046037 GMP metabolic process;GO:0046040 IMP metabolic process;GO:0046085 adenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZIZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJB4-1", "uniprot_id": "IKKA_CHICK", "mass": 86144.0, "length": 759, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit alpha", "gene_name": "CHUK", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHUK; IKKA; RCJMB04_19h23", "gene_names_refseq": "", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit alpha; 2.7.11.10; Conserved helix-loop-helix ubiquitous kinase; I kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423669); (R-GGA-1227739); (R-GGA-1227892); (R-GGA-434001); (R-GGA-434131)", "pathway_count": 5, "publication_count": 18, "publication_id_list": "11002417;11057907;12221085;15145317;15371334;15642098;16056267;16115877;16153868;17047224;17135271;17332413;17496917;18984593;19479062;19666475;20097753;9689078", "class_list": "", "function": "Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.10;2.3.2.27", "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008385 IkappaB kinase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0071356 cellular response to tumor necrosis factor;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q5ZJB4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJF4-1", "uniprot_id": "PRDX6_CHICK", "mass": 24977.0, "length": 224, "protein_name": "Peroxiredoxin-6", "gene_name": "PRDX6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PRDX6; RCJMB04_18k11", "gene_names_refseq": "", "protein_names_uniprotkb": "Peroxiredoxin-6; 1-Cys PRX; 1-Cys peroxiredoxin; 1.11.1.27; 2.3.1.23; 3.1.1.4; Acidic calcium-independent phospholipase A2; Glutathione-dependent peroxiredoxin; LPC acyltransferase 5; LPCAT-5; Lyso-PC acyltransferase 5; Lysophosphatidylcholine acyltransferase 5; NSGPx; Non-selenium glutathione peroxidase; aiPLA2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:429062)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;3.1.1.4;3.1.1.32;3.1.1.3;3.1.1.5;2.3.1.23;2.3.1.51;2.3.1.n7;2.3.1.-", "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0051920 peroxiredoxin activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJK4-1", "uniprot_id": "STK4_CHICK", "mass": 55337.0, "length": 486, "protein_name": "Serine/threonine-protein kinase 4", "gene_name": "STK4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "STK4; RCJMB04_17i1", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase 4; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:419187)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0051262 protein tetramerization;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJK4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJM7-1", "uniprot_id": "DCK2_CHICK", "mass": 31240.0, "length": 265, "protein_name": "Deoxycytidine kinase 2", "gene_name": "DCK2", "organism": "Chicken", "refseq_name": "deoxycytidine kinase 2", "refseq_ac": "NP_001072968", "gene_names_uniprotkb": "DCK2; DAK; RCJMB04_17b6", "gene_names_refseq": "DAK; DCK2; GgdCK2; MTDPS3; dGK", "protein_names_uniprotkb": "Deoxycytidine kinase 2; 2.7.1.113; 2.7.1.74; 2.7.1.76; Deoxyadenosine kinase 2; Deoxyguanosine kinase 2; GgdCK2", "protein_names_refseq": "deoxyadenosine kinase 2; deoxyadenosine kinase; deoxycytidine kinase 2; deoxycytidine kinase-like; deoxyguanosine kinase 2; dihydroxyacetone kinase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:770922)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15592404;15642098;27906638", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720407.1, HAEK01040905.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1. On Dec 9, 2006 this sequence version replaced XP_001233359.1., [RefSeq]; Phosphorylates the deoxyribonucleosides deoxyadenosine, deoxycytidine and deoxyguanosine (PubMed:27906638). Shows highest activity against deoxyguanosine followed by deoxycytidine and then deoxyadenosine (PubMed:27906638). Shows only very minor activity against deoxyuridine and deoxythymidine (PubMed:27906638)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6TYL4", "ec_number_list": "2.7.1.113;2.7.1.76;2.7.1.74", "go_molecular_function": "GO:0004138 deoxyguanosine kinase activity;GO:0005524 ATP binding;GO:0004137 deoxycytidine kinase activity;GO:0019136 deoxynucleoside kinase activity;GO:0004136 deoxyadenosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0009157 deoxyribonucleoside monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZJM7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJN2-1", "uniprot_id": "RB11A_CHICK", "mass": 24439.0, "length": 216, "protein_name": "Ras-related protein Rab-11A", "gene_name": "RAB11A", "organism": "Chicken", "refseq_name": "ras-related protein Rab-11A", "refseq_ac": "NP_001005827", "gene_names_uniprotkb": "RAB11A; RCJMB04_16p4", "gene_names_refseq": "RAB11A", "protein_names_uniprotkb": "Ras-related protein Rab-11A; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-11A", "tax_id": 9031, "disease": "", "pathway": " (gga:415544)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720402.1, HAEK01003122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000246.1. On Jan 13, 2005 this sequence version replaced XP_413914.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11A regulates endocytic recycling (By similarity). May also be involved in the regulation of preciliary trafficking and neosynthesized protein export (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0030666 endocytic vesicle membrane", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0006887 exocytosis;GO:0032402 melanosome transport;GO:0061512 protein localization to cilium;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJN2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJT0-1", "uniprot_id": "SUV3_CHICK", "mass": 88776.0, "length": 794, "protein_name": "ATP-dependent RNA helicase SUPV3L1, mitochondrial", "gene_name": "SUPV3L1", "organism": "Chicken", "refseq_name": "ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor", "refseq_ac": "NP_001006498", "gene_names_uniprotkb": "SUPV3L1; RCJMB04_16a1", "gene_names_refseq": "SUPV3L1", "protein_names_uniprotkb": "ATP-dependent RNA helicase SUPV3L1, mitochondrial; 3.6.4.13; SUV3-like protein 1; Suppressor of var1 3-like protein 1", "protein_names_refseq": "ATP-dependent RNA helicase SUPV3L1, mitochondrial precursor; ATP-dependent RNA helicase SUPV3L1, mitochondrial; SUV3-like protein 1; suppressor of var1 3-like protein 1; suppressor of var1, 3-like 1", "tax_id": 9031, "disease": "", "pathway": " (gga:423697)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720354.1, HAEL01006646.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ720354.1. On Jan 13, 2005 this sequence version replaced XP_421578.1., [RefSeq]; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0045025 mitochondrial degradosome", "go_biological_process": "GO:0006310 DNA recombination;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0007005 mitochondrion organization;GO:0000962 positive regulation of mitochondrial RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJT0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZJV9-1", "uniprot_id": "CNOT7_CHICK", "mass": 32745.0, "length": 285, "protein_name": "CCR4-NOT transcription complex subunit 7", "gene_name": "CNOT7", "organism": "Chicken", "refseq_name": "CCR4-NOT transcription complex subunit 7", "refseq_ac": "NP_001006454", "gene_names_uniprotkb": "CNOT7; CAF1; RCJMB04_15f9", "gene_names_refseq": "CAF1; CNOT7", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 7; 3.1.13.4; CAF-1; CCR4-associated factor 1", "protein_names_refseq": "CAF-1; CCR4-NOT transcription complex subunit 7; CCR4-associated factor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:422733); (R-GGA-429947); (R-GGA-6804115)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720325.1, SRR13267654.159339.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1. On Jan 13, 2005 this sequence version replaced XP_420688.1., [RefSeq]; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.13.4;2.3.2.27;3.6.4.13", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004532 RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0016607 nuclear speck;GO:0000932 P-body;GO:0030014 CCR4-NOT complex;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJV9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZKD1-1", "uniprot_id": "CEPT1_CHICK", "mass": 46097.0, "length": 416, "protein_name": "Choline/ethanolaminephosphotransferase 1", "gene_name": "CEPT1", "organism": "Chicken", "refseq_name": "choline/ethanolaminephosphotransferase 1", "refseq_ac": "NP_001006392", "gene_names_uniprotkb": "CEPT1; RCJMB04_11l7", "gene_names_refseq": "CEPT1", "protein_names_uniprotkb": "Choline/ethanolaminephosphotransferase 1; 1-alkenyl-2-acylglycerol choline phosphotransferase; 2.7.8.1; 2.7.8.22; 2.7.8.2", "protein_names_refseq": "1-alkenyl-2-acylglycerol choline phosphotransferase; choline/ethanolaminephosphotransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:421152)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720153.1, SRR13267649.221169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992544 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1. On Sep 23, 2021 this sequence version replaced NP_001006392.1., [RefSeq]; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.8.1;2.7.8.2;2.7.8.22", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity;GO:0004307 ethanolaminephosphotransferase activity;GO:0047359 1-alkenyl-2-acylglycerol choline phosphotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKD1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZKE7-1", "uniprot_id": "KCY_CHICK", "mass": 22172.0, "length": 196, "protein_name": "UMP-CMP kinase", "gene_name": "CMPK", "organism": "Chicken", "refseq_name": "UMP-CMP kinase", "refseq_ac": "NP_001026735", "gene_names_uniprotkb": "CMPK; CMPK1; RCJMB04_11f2", "gene_names_refseq": "CK; CMPK1; CMPK", "protein_names_uniprotkb": "UMP-CMP kinase; 2.7.4.14; 2.7.4.6; CK; Deoxycytidylate kinase; Nucleoside-diphosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate/cytidine monophosphate kinase; dCMP kinase", "protein_names_refseq": "UMP-CMP kinase; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; cytidine monophosphate kinase; cytidylate kinase; uridine monophosphate kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:429100)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720137.1, AJ453220.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000239.1. On Aug 8, 2005 this sequence version replaced XP_426656.1., [RefSeq]; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.4.6;2.7.4.3;2.7.4.10;2.7.4.4;2.7.4.14;2.7.4.9", "go_molecular_function": "GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity;GO:0036430 CMP kinase activity;GO:0036431 dCMP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006225 UDP biosynthetic process;GO:0046705 CDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKE7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZKG3-1", "uniprot_id": "DNA2_CHICK", "mass": 111679.0, "length": 992, "protein_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "gene_name": "DNA2", "organism": "Chicken", "refseq_name": "DNA replication ATP-dependent helicase/nuclease DNA2", "refseq_ac": "NP_001006497", "gene_names_uniprotkb": "DNA2; DNA2L; RCJMB04_11a16", "gene_names_refseq": "DNA2L; DNA2", "protein_names_uniprotkb": "DNA replication ATP-dependent helicase/nuclease DNA2; DNA 5'-3' helicase DNA2; DNA replication ATP-dependent helicase-like homolog", "protein_names_refseq": "DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA2-like helicase", "tax_id": 9031, "disease": "", "pathway": " (gga:423688)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15592404;15642098;18612635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720121.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ720121.1. On Jan 13, 2005 this sequence version replaced XP_421569.1., [RefSeq]; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is absent to weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1NWZ9", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006284 base-excision repair;GO:0006260 DNA replication;GO:0045740 positive regulation of DNA replication;GO:0000729 DNA double-strand break processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZKG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZKL6-1", "uniprot_id": "MBOA2_CHICK", "mass": 59552.0, "length": 518, "protein_name": "Membrane-bound glycerophospholipid O-acyltransferase 2", "gene_name": "mboat2", "organism": "Chicken", "refseq_name": "membrane-bound glycerophospholipid O-acyltransferase 2", "refseq_ac": "NP_001026261", "gene_names_uniprotkb": "mboat2; RCJMB04_10b24; oact2", "gene_names_refseq": "LPLAT 2; MBOAT2; OACT2", "protein_names_uniprotkb": "Membrane-bound glycerophospholipid O-acyltransferase 2; 1-acylglycerophosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 2.3.1.-; 2.3.1.23; 2.3.1.51; 2.3.1.n7; LPLAT 2; Lysophospholipid acyltransferase 2; Membrane-bound O-acyltransferase domain-containing protein 2; O-acyltransferase domain-containing protein 2", "protein_names_refseq": "1-acylglycerophosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; O-acyltransferase (membrane bound) domain containing 2; lysophospholipid acyltransferase 2; membrane-bound O-acyltransferase domain-containing protein 2; membrane-bound glycerophospholipid O-acyltransferase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:421925); (R-GGA-1482788); (R-GGA-1482839)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720068.1, SRR13267661.25856.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ445321.1, AJ721263.1, AJ720068.1, JAENSK010000066.1, CR524182.1, BU423428.1, CV862316.1 and HAEK01065227.1. On Aug 8, 2005 this sequence version replaced XP_419940.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. May catalyze preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Prefers oleoyl-CoA as the acyl donor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.11.1.27;2.3.1.51;2.3.1.23;2.3.1.n6;2.3.1.-;3.1.1.4;2.3.1.n7;2.3.1.15", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0016746 acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0032330 regulation of chondrocyte differentiation;GO:0008654 phospholipid biosynthetic process;GO:0036150 phosphatidylserine acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZKM0-1", "uniprot_id": "DTBP1_CHICK", "mass": 39593.0, "length": 351, "protein_name": "Dysbindin", "gene_name": "DTNBP1", "organism": "Chicken", "refseq_name": "dysbindin", "refseq_ac": "NP_001006372", "gene_names_uniprotkb": "DTNBP1; Bloc1s8; RCJMB04_10b8", "gene_names_refseq": "Bloc1s8; DTNBP1", "protein_names_uniprotkb": "Dysbindin; BLOC-1 subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1", "protein_names_refseq": "BLOC-1 subunit 8; biogenesis of lysosome-related organelles complex 1 subunit 8; dysbindin-1; dysbindin", "tax_id": 9031, "disease": "", "pathway": " (gga:420840)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720064.1, HAEK01022099.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000040.1. On Jan 13, 2005 this sequence version replaced XP_418931.1., [RefSeq]; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0031175 neuron projection development;GO:0048812 neuron projection morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0060155 platelet dense granule organization;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKM0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZL13-1", "uniprot_id": "NUD19_CHICK", "mass": 42122.0, "length": 378, "protein_name": "Acyl-coenzyme A diphosphatase NUDT19", "gene_name": "NUDT19", "organism": "Chicken", "refseq_name": "acyl-coenzyme A diphosphatase NUDT19 precursor", "refseq_ac": "NP_001026629", "gene_names_uniprotkb": "NUDT19; RCJMB04_8e7", "gene_names_refseq": "NUDT19", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase NUDT19; 3.6.1.-; 3.6.1.77; Nucleoside diphosphate-linked moiety X motif 19; Nudix motif 19", "protein_names_refseq": "acyl-coenzyme A diphosphatase NUDT19 precursor; acyl-coenzyme A diphosphatase NUDT19; nucleoside diphosphate-linked moiety X motif 19, mitochondrial; nudix (nucleoside diphosphate linked moiety X)-type motif 19; nudix motif 19", "tax_id": 9031, "disease": "", "pathway": " (gga:427548); (R-GGA-390918); (R-GGA-9033241)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719921.1, SRR13267651.665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000248.1. On Aug 8, 2005 this sequence version replaced XP_425120.1., [RefSeq]; Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;1.14.13.39;4.1.3.4;4.1.2.63;3.6.1.9;3.6.1.68;3.6.1.76;2.3.1.137;4.1.1.9;3.6.1.77;5.3.3.21;2.3.1.42;3.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.2.27;3.4.24.56;1.3.1.38;3.4.21.-;1.1.1.42;1.5.3.13;1.11.1.6;1.1.3.15;2.6.1.51;2.6.1.44;1.1.1.35;4.2.1.17;5.3.3.8;2.3.1.176;2.3.1.16;2.3.1.155;2.3.1.7;1.5.3.1;1.5.3.7;2.5.1.18;1.3.1.124;5.1.99.4;3.6.1.-;3.6.1.17", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0036114 medium-chain fatty-acyl-CoA catabolic process;GO:2001294 malonyl-CoA catabolic process;GO:0015938 coenzyme A catabolic process;GO:0044580 butyryl-CoA catabolic process;GO:1901289 succinyl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZL18-1", "uniprot_id": "P20D1_CHICK", "mass": 57162.0, "length": 517, "protein_name": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1", "gene_name": "PM20D1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PM20D1; RCJMB04_8d17", "gene_names_refseq": "", "protein_names_uniprotkb": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1; 3.5.1.114; 3.5.1.14; Peptidase M20 domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:419838)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.99;3.5.1.14;3.5.1.114", "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity;GO:0016829 lyase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0097009 energy homeostasis;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZL74-1", "uniprot_id": "VAMP7_CHICK", "mass": 24682.0, "length": 220, "protein_name": "Vesicle-associated membrane protein 7", "gene_name": "VAMP7", "organism": "Chicken", "refseq_name": "vesicle-associated membrane protein 7", "refseq_ac": "NP_001026292", "gene_names_uniprotkb": "VAMP7; RCJMB04_7f19; SYBL1", "gene_names_refseq": "SYBL1; VAMP7", "protein_names_uniprotkb": "Vesicle-associated membrane protein 7; Synaptobrevin-like protein 1", "protein_names_refseq": "synaptobrevin-like 1; synaptobrevin-like protein 1; vesicle-associated membrane protein 7", "tax_id": 9031, "disease": "", "pathway": " (gga:422297)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000071.1. On Aug 8, 2005 this sequence version replaced XP_420275.1., [RefSeq]; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0015031 protein transport;GO:0043312 neutrophil degranulation;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZLC7-1", "uniprot_id": "MARE1_CHICK", "mass": 29143.0, "length": 258, "protein_name": "Microtubule-associated protein RP/EB family member 1", "gene_name": "MAPRE1", "organism": "Chicken", "refseq_name": "microtubule-associated protein RP/EB family member 1", "refseq_ac": "NP_001026031", "gene_names_uniprotkb": "MAPRE1; RCJMB04_6l6", "gene_names_refseq": "MAPRE1", "protein_names_uniprotkb": "Microtubule-associated protein RP/EB family member 1", "protein_names_refseq": "microtubule-associated protein RP/EB family member 1", "tax_id": 9031, "disease": "", "pathway": " (gga:419288)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719807.1, HAEK01001101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. On Aug 8, 2005 this sequence version replaced XP_417461.1. Sequence Note: This sequence has been modified as follows: removed 23 bp suspected to be vector contamination from the 3' end., [RefSeq]; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0030981 cortical microtubule cytoskeleton;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005925 focal adhesion", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0016477 cell migration;GO:0051301 cell division;GO:0031116 positive regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZLC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZLF4-1", "uniprot_id": "ZNT5_CHICK", "mass": 84777.0, "length": 770, "protein_name": "Proton-coupled zinc antiporter SLC30A5", "gene_name": "SLC30A5", "organism": "Chicken", "refseq_name": "proton-coupled zinc antiporter SLC30A5", "refseq_ac": "NP_001026590", "gene_names_uniprotkb": "SLC30A5; RCJMB04_6h4; ZNT5", "gene_names_refseq": "SLC30A5; ZnT5", "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A5; Solute carrier family 30 member 5; Zinc transporter 5; ZnT-5", "protein_names_refseq": "proton-coupled zinc antiporter SLC30A5; solute carrier family 30 (zinc transporter), member 5; zinc transporter 5; znT-5", "tax_id": 9031, "disease": "", "pathway": " (gga:427173)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15525635;15642098;16636052", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719780.1, AY703476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000089.1. On Aug 14, 2005 this sequence version replaced NP_001026590.1., [RefSeq]; Contributes to the conversion of apo-alkaline phosphatase to holo-alkaline phosphatase, [RefSeq, PubMed]; Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15525635). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15525635)., [UniProtKB, PubMed]; ZnT5(-)ZnT7(-/-) cells showed exacerbation of the unfolded protein response as did the wild-type cells cultured under a zinc-deficient condition, revealing that both complexes play a role in homeostatic maintenance of secretory pathway function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5MNV7", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0140826 zinc:proton antiporter activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006882 intracellular zinc ion homeostasis;GO:0006506 GPI anchor biosynthetic process;GO:0062111 zinc ion import into organelle;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZLF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZLL8-1", "uniprot_id": "GPAT3_CHICK", "mass": 50112.0, "length": 446, "protein_name": "Glycerol-3-phosphate acyltransferase 3", "gene_name": "GPAT3", "organism": "Chicken", "refseq_name": "glycerol-3-phosphate acyltransferase 3", "refseq_ac": "NP_001026316", "gene_names_uniprotkb": "GPAT3; AGPAT9; RCJMB04_5j9", "gene_names_refseq": "AGPAT 10; AGPAT9; GPAT3; LPAAT-THETA", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 3; 1-AGP acyltransferase 9; 1-AGPAT 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 2.3.1.15; 2.3.1.51; AGPAT 10; GPAT-3; LPAAT-theta; Lysophosphatidic acid acyltransferase theta", "protein_names_refseq": "1-AGP acyltransferase 9; 1-AGPAT 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 1-acylglycerol-3-phosphate O-acyltransferase 9; GPAT-3; glycerol-3-phosphate acyltransferase 3; lysophosphatidic acid acyltransferase theta", "tax_id": 9031, "disease": "", "pathway": " (gga:422610)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719716.1, SRR13267654.215044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000073.1. On Sep 23, 2021 this sequence version replaced NP_001026316.1., [RefSeq]; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.51;2.3.1.15;2.3.1.-;2.3.1.23;2.3.1.n7", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZLL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZLN1-1", "uniprot_id": "PGAM1_CHICK", "mass": 28898.0, "length": 254, "protein_name": "Phosphoglycerate mutase 1", "gene_name": "PGAM1", "organism": "Chicken", "refseq_name": "phosphoglycerate mutase 1", "refseq_ac": "NP_001026727", "gene_names_uniprotkb": "PGAM1; RCJMB04_5g20", "gene_names_refseq": "PGAM1", "protein_names_uniprotkb": "Phosphoglycerate mutase 1; 5.4.2.11; 5.4.2.4; BPG-dependent PGAM 1", "protein_names_refseq": "BPG-dependent PGAM 1; phosphoglycerate mutase 1 (brain); phosphoglycerate mutase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:428969); (R-GGA-352875); (R-GGA-352882)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "15642098;1593633;16287166;2110163;2985560;3094011;3539098;3885220;4463937;499525;6303388;6345546;6574503;7629021;7768978;7916593;8182283;9434147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01001087.1, HAEL01000018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000232.1. On Aug 8, 2005 this sequence version replaced XP_426526.1., [RefSeq]; Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate, a crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P84174", "ec_number_list": "5.4.2.11;5.4.2.4", "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q5ZLN1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZLV4-1", "uniprot_id": "NSUN2_CHICK", "mass": 90845.0, "length": 796, "protein_name": "RNA cytosine-C(5)-methyltransferase NSUN2", "gene_name": "NSUN2", "organism": "Chicken", "refseq_name": "RNA cytosine-C(5)-methyltransferase NSUN2", "refseq_ac": "NP_001026175", "gene_names_uniprotkb": "NSUN2; RCJMB04_4l11", "gene_names_refseq": "NSUN2", "protein_names_uniprotkb": "RNA cytosine-C(5)-methyltransferase NSUN2; 2.1.1.-; 2.1.1.203; NOL1/NOP2/Sun domain family member 2; mRNA cytosine C(5)-methyltransferase; tRNA cytosine C(5)-methyltransferase", "protein_names_refseq": "NOL1/NOP2/Sun domain family, member 2; RNA cytosine-C(5)-methyltransferase NSUN2; mRNA cytosine C(5)-methyltransferase; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:420938)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719630.1, SRR13267655.132630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000041.1. On Oct 25, 2021 this sequence version replaced NP_001026175.1., [RefSeq]; RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs). Also mediates C(5)-methylation of mitochondrial tRNAs. Catalyzes cytosine C(5)-methylation of mRNAs, leading to stabilize them and prevent mRNA decay. Cytosine C(5)-methylation of mRNAs also regulates mRNA export. Also mediates cytosine C(5)-methylation of non-coding RNAs, such as vault RNAs (vtRNAs), promoting their processing into regulatory small RNAs. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.203;2.1.1.-", "go_molecular_function": "GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0000049 tRNA binding;GO:0062152 mRNA (cytidine-5-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005819 spindle", "go_biological_process": "GO:0010793 regulation of mRNA export from nucleus;GO:0030488 tRNA methylation;GO:2000736 regulation of stem cell differentiation;GO:0036416 tRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZLV4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZM14-1", "uniprot_id": "NHRF1_CHICK", "mass": 35805.0, "length": 333, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "gene_name": "NHERF1", "organism": "Chicken", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "refseq_ac": "NP_001006424", "gene_names_uniprotkb": "NHERF1; NHERF; RCJMB04_3g21; SLC9A3R1", "gene_names_refseq": "EBP50; NHERF-1; NHERF1; NHERF; SLC9A3R1", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1; EBP50; Ezrin-radixin-moesin-binding phosphoprotein 50; NHERF-1; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1", "protein_names_refseq": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1; ezrin-radixin-moesin-binding phosphoprotein 50; regulatory cofactor of Na(+)/H(+) exchanger; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1", "tax_id": 9031, "disease": "", "pathway": " (gga:422108)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719570.1, SRR13267654.166910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000317.1. On Sep 23, 2021 this sequence version replaced NP_001006424.1., [RefSeq]; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0017081 chloride channel regulator activity;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0012505 endomembrane system;GO:0016324 apical plasma membrane;GO:0030175 filopodium;GO:0071944 cell periphery", "go_biological_process": "GO:0034635 glutathione transport;GO:0072659 protein localization to plasma membrane;GO:0016055 Wnt signaling pathway;GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZM14-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZM39-1", "uniprot_id": "BCL6_CHICK", "mass": 79587.0, "length": 708, "protein_name": "B-cell lymphoma 6 protein homolog", "gene_name": "BCL6", "organism": "Chicken", "refseq_name": "B-cell lymphoma 6 protein homolog", "refseq_ac": "NP_001012948", "gene_names_uniprotkb": "BCL6; RCJMB04_3d20", "gene_names_refseq": "BCL6; Bcl-6", "protein_names_uniprotkb": "B-cell lymphoma 6 protein homolog", "protein_names_refseq": "B-cell CLL/lymphoma 6 (zinc finger protein 51); B-cell lymphoma 6 protein homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:424912)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;21674482", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719545.1, SRR13267655.119125.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719545.1. On Mar 14, 2005 this sequence version replaced XP_422722.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Findings reveal a complex regulatory network in which Bcl6 acts as a key element dictating the transition of DT40 B cells to plasma cells., [RefSeq, PubMed]; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunoglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZM39-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZM44-1", "uniprot_id": "CHP1_CHICK", "mass": 22447.0, "length": 195, "protein_name": "Calcineurin B homologous protein 1", "gene_name": "CHP1", "organism": "Chicken", "refseq_name": "calcineurin B homologous protein 1", "refseq_ac": "NP_001007931", "gene_names_uniprotkb": "CHP1; CHP; RCJMB04_3d7", "gene_names_refseq": "CHP1; CHP", "protein_names_uniprotkb": "Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein p22; calcineurin B homologous protein 1; calcineurin B-like protein; calcineurin homologous protein; calcium binding protein P22; calcium-binding protein CHP; calcium-binding protein p22", "tax_id": 9031, "disease": "", "pathway": " (gga:423211)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;17392381", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719540.1, CR406197.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719540.1. On Dec 15, 2004 this sequence version replaced XP_421135.1., [RefSeq]; Calcineurin homologous protein plays an essential role in stabilizing NHE-1 (Na+/K+ exhanger isoform 1)., [RefSeq, PubMed]; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription. Acts as a negative regulator of the calcineurin/NFAT signaling pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0006469 negative regulation of protein kinase activity;GO:0061024 membrane organization;GO:0050821 protein stabilization;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZM44-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZMA3-1", "uniprot_id": "RBM24_CHICK", "mass": 23892.0, "length": 225, "protein_name": "RNA-binding protein 24", "gene_name": "RBM24", "organism": "Chicken", "refseq_name": "RNA-binding protein 24", "refseq_ac": "NP_001012881", "gene_names_uniprotkb": "RBM24; RCJMB04_2l21", "gene_names_refseq": "RBM24", "protein_names_uniprotkb": "RNA-binding protein 24; RNA-binding motif protein 24", "protein_names_refseq": "RNA-binding protein 24", "tax_id": 9031, "disease": "", "pathway": " (gga:420846)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;25217815", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719481.1, BX933592.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000040.1. On Mar 10, 2015 this sequence version replaced NP_001012881.1. Transcript Variant: This variant (1) encodes the functional protein., [RefSeq]; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating MYOG levels. Binds to a huge amount of mRNAs (By similarity). Involved in embryonic heart development and myogenic differentiation of somitic muscle progenitors (PubMed:25217815)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Using morpholino knockdown approach, we further show that Rbm24 is required for somitic myogenic progenitor cells to differentiate into muscle cells during chick somitic myogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0097157 pre-mRNA intronic binding;GO:0003730 mRNA 3'-UTR binding;GO:1990715 mRNA CDS binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0010830 regulation of myotube differentiation;GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZMA3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZMK5-1", "uniprot_id": "JMJD6_CHICK", "mass": 47760.0, "length": 414, "protein_name": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "gene_name": "JMJD6", "organism": "Chicken", "refseq_name": "bifunctional arginine demethylase and lysyl-hydroxylase JMJD6", "refseq_ac": "NP_001025874", "gene_names_uniprotkb": "JMJD6; PTDSR; RCJMB04_1m8", "gene_names_refseq": "JMJD6; PTDSR", "protein_names_uniprotkb": "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; Jumonji domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptor; Protein PTDSR", "protein_names_refseq": "Protein PTDSR; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; histone arginine demethylase JMJD6; jmjC domain-containing protein 6; jumonji domain-containing protein 6; lysyl-hydroxylase JMJD6; peptide-lysine 5-dioxygenase JMJD6; phosphatidylserine receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:417355)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719379.1, SRR13267652.22971.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000316.1. On Sep 23, 2021 this sequence version replaced NP_001025874.1., [RefSeq]; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity (By similarity). Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.-", "go_molecular_function": "GO:0033746 histone H3R2 demethylase activity;GO:0033749 histone H4R3 demethylase activity;GO:0070815 peptidyl-lysine 5-dioxygenase activity;GO:0046872 metal ion binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0030154 cell differentiation;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q5ZQU2-1", "uniprot_id": "NPAS2_CHICK", "mass": 91178.0, "length": 815, "protein_name": "Neuronal PAS domain-containing protein 2", "gene_name": "NPAS2", "organism": "Chicken", "refseq_name": "neuronal PAS domain-containing protein 2", "refseq_ac": "NP_001025713", "gene_names_uniprotkb": "NPAS2; MOP4", "gene_names_refseq": "MOP4; NPAS2", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 2; MOP4; Member of PAS protein 4; Neuronal PAS2", "protein_names_refseq": "bHLH-PAS clock protein; bHLH-PAS transcription factor MOP4; member of PAS protein 4; neuronal PAS domain-containing protein 2; neuronal PAS2", "tax_id": 9031, "disease": "", "pathway": " (gga:395433)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10931848;20345751", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF396828.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000025.1. On Dec 3, 2021 this sequence version replaced NP_001025713.1. The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Feb 2014]., [RefSeq]; CLOCK plays the predominant role in the chicken photoreceptor circadian clockwork mechanism, including the regulation of NPAS2 expression, [RefSeq, PubMed]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. NPAS2 positively regulates the circadian expression of AANAT in the retinal photoreceptor cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DG34", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051775 response to redox state;GO:0006974 DNA damage response;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZQU2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q65Z91-1", "uniprot_id": "TSK_CHICK", "mass": 40710.0, "length": 369, "protein_name": "Tsukushi", "gene_name": "TSKU", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TSKU; LRRC54; TSK", "gene_names_refseq": "", "protein_names_uniprotkb": "Tsukushi; C-TSK; Leucine-rich repeat-containing protein 54", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:419088)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15363410;16319115;16943268;21856951;26299926", "class_list": "", "function": "Contributes to various developmental events through its interactions with multiple signaling pathways (PubMed:15363410, PubMed:16943268, PubMed:21856951). Dorsalizing factor involved in the induction of Hensen's node by inhibiting bone morphogenetic proteins during gastrulation and by enhancing DVR1/VG1 activity (PubMed:15363410, PubMed:16943268). Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye (PubMed:21856951)., [UniProtKB, PubMed, PubMed, PubMed]; Shows strong bone morphogenetic protein antagonistic activity., [UniProtKB, PubMed]; Shows weak bone morphogenetic protein antagonistic activity., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4W6V7", "ec_number_list": "", "go_molecular_function": "GO:0019955 cytokine binding;GO:0036122 BMP binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0097009 energy homeostasis;GO:0090009 primitive streak formation;GO:0003431 growth plate cartilage chondrocyte development;GO:0098868 bone growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q65Z91-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q66PG3-1", "uniprot_id": "LARG1_CHICK", "mass": 88046.0, "length": 756, "protein_name": "Xylosyl- and glucuronyltransferase LARGE1", "gene_name": "LARGE1", "organism": "Chicken", "refseq_name": "xylosyl- and glucuronyltransferase LARGE1", "refseq_ac": "NP_001004383", "gene_names_uniprotkb": "LARGE1; LARGE", "gene_names_refseq": "LARGE1; LARGE", "protein_names_uniprotkb": "Xylosyl- and glucuronyltransferase LARGE1; 2.4.-.-; Acetylglucosaminyltransferase-like 1A; Glycosyltransferase-like protein", "protein_names_refseq": "acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; glycosyltransferase-like 1A; glycosyltransferase-like protein LARGE1; like-glycosyltransferase; xylosyl- and glucuronyltransferase LARGE1", "tax_id": 9031, "disease": "", "pathway": " (gga:418062)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15958417", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY662337.1, SRR13267655.255000.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY662337.1. On Sep 17, 2004 this sequence version replaced XP_416298.1., [RefSeq]; Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer (By similarity). Plays a key role in skeletal muscle function and regeneration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.-;2.4.1.-;2.4.-.-", "go_molecular_function": "GO:0042285 xylosyltransferase activity;GO:0030145 manganese ion binding;GO:0015020 glucuronosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060538 skeletal muscle organ development;GO:0009101 glycoprotein biosynthetic process;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66PG3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q679P3-1", "uniprot_id": "PDLI7_CHICK", "mass": 45724.0, "length": 416, "protein_name": "PDZ and LIM domain protein 7", "gene_name": "PDLIM7", "organism": "Chicken", "refseq_name": "PDZ and LIM domain protein 7 isoform 1", "refseq_ac": "NP_001005345", "gene_names_uniprotkb": "PDLIM7; LMP; RCJMB04_14g20", "gene_names_refseq": "LMP-4; LMP; PDLIM7", "protein_names_uniprotkb": "PDZ and LIM domain protein 7; LIM mineralization protein; LMP", "protein_names_refseq": "Enigma 90kDa large protein; Enigma LIM-domain loss protein; Enigma protein alpha; Enigma protein beta; Enigma protein gamma; LIM mineralization protein; LIM mineralizing protein; PDZ and LIM domain 7 (enigma); PDZ and LIM domain protein 7 isoform 1; PDZ and LIM domain protein 7", "tax_id": 9031, "disease": "", "pathway": " (gga:416362)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15302601;15642098;16880269", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY376690.1, SRR13267659.53159.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000256.1. On Dec 8, 2020 this sequence version replaced NP_001005345.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; LMP4 acts as a repressor of Tbx5 activity., [RefSeq, PubMed]; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. May be involved in bone formation (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZJY4", "ec_number_list": "", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0008134 transcription factor binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0030036 actin cytoskeleton organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q679P3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6A2H4-1", "uniprot_id": "IL10_CHICK", "mass": 20514.0, "length": 175, "protein_name": "Interleukin-10", "gene_name": "IL10", "organism": "Chicken", "refseq_name": "interleukin-10 precursor", "refseq_ac": "NP_001004414", "gene_names_uniprotkb": "IL10", "gene_names_refseq": "IL-10; IL10; interleukin-10", "protein_names_uniprotkb": "Interleukin-10; IL-10", "protein_names_refseq": "interleukin-10 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:428264); (R-GGA-6783783)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15294985;15932414;16996141;17045659;17575181;22113479;22270623;31520870", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF554720.1, AJ621254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2812694 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000356.1. On Jun 3, 2007 this sequence version replaced NP_001004414.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Data show that IL-10, IFN-gamma and TNF-alpha contents in the cecal tonsil were significantly decreased in the 30, 45 and 60 mg/kg groups, while IL-6 content in the cecal tonsil was only decreased in 60 mg/kg at 14 and 28 days of age., [RefSeq, PubMed]; Differences in spatial regulation of IL-10 and IFNgamma may indicate Eimeria species induce slightly different cytokine responses., [RefSeq, PubMed]; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Vitiligo in Smyth line chickens appears to be a Th1-polarized autoimmune disease, whereby IFN-gamma expression is strongly associated with parallel increases in IL-10 and IL-21, particularly during the early and active stages of vitiligo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6A2H5", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:1903034 regulation of response to wounding;GO:1903672 positive regulation of sprouting angiogenesis;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6A2H4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6DV79-1", "uniprot_id": "STAT3_CHICK", "mass": 88171.0, "length": 771, "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "organism": "Chicken", "refseq_name": "signal transducer and activator of transcription 3 isoform 1", "refseq_ac": "NP_001026102", "gene_names_uniprotkb": "STAT3; RCJMB04_38l20", "gene_names_refseq": "STAT3", "protein_names_uniprotkb": "Signal transducer and activator of transcription 3", "protein_names_refseq": "signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3 isoform 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420027)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15642098;15910996;21279516;22417645;23942241;24858374;27868312;28597334;30787154;38387235", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851819.1, SRR13267654.23796.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000365.1. On or before Jan 20, 2018 this sequence version replaced XP_015155085.1, NP_001026102.1., [RefSeq]; Avian blood contains a leptin-like molecule that specifically binds to leptin receptor, suggesting that the leptin system is conserved across all vertebrate classes., [RefSeq, PubMed]; C3a induces retina regeneration via STAT3 activation, which activates the injury- and inflammation-responsive factors, IL-6, IL-8 and TNF-alpha and sets forth regulation of Wnt2b, Six3 and Sox2, genes associated with retina stem and progenitor cells., [RefSeq, PubMed]; It is a gene related to signal transduction., [RefSeq, PubMed]; Our results suggested that JAK-STAT effectively promoted the formation of primordial germ cells in the genital ridge during early embryogenesis in vivo and played a positive role in the regulation of embryonic stem cells to spermatogonial stem cells differentiation in vitro, with JAK2 and STAT3 functioning as pivotal factors for intracellular signal transduction, [RefSeq, PubMed]; STAT3 could play in the protection of cardiovascular function in a developing organism, [RefSeq, PubMed]; These data suggest that in ovo leptin administration affects angiogenesis and embryo growth in female chicken embryos, probably through STAT3-mediated VEGF/nitric oxide pathways., [RefSeq, PubMed]; These results suggest that MDV disables the ATR-Chk1 pathway through STAT3 activation to benefit its replication. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes., [UniProtKB, PubMed]; UBE2J1 promotes ALV-A proviral DNA synthesis through the STAT3/IRF1 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5F331", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response;GO:0040014 regulation of multicellular organism growth;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6DV79-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6JHU7-1", "uniprot_id": "P3H2_CHICK", "mass": 78430.0, "length": 694, "protein_name": "Prolyl 3-hydroxylase 2", "gene_name": "P3H2", "organism": "Chicken", "refseq_name": "prolyl 3-hydroxylase 2 isoform 1 precursor", "refseq_ac": "NP_001001530", "gene_names_uniprotkb": "P3H2; LEPREL1", "gene_names_refseq": "LEPREL1; P3H2", "protein_names_uniprotkb": "Prolyl 3-hydroxylase 2; 1.14.11.7; Leprecan-like protein 1", "protein_names_refseq": "leprecan-like 1; leprecan-like protein 1; prolyl 3-hydroxylase 2 isoform 1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:414143); (R-GGA-1650814)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15044469", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY463529.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. On Dec 16, 2021 this sequence version replaced NP_001001530.1., [RefSeq]; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (By similarity). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.7;5.2.1.8", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0019797 procollagen-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005604 basement membrane;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0019511 peptidyl-proline hydroxylation;GO:0032963 collagen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6JHU7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6JHU8-1", "uniprot_id": "P3H1_CHICK", "mass": 81676.0, "length": 725, "protein_name": "Prolyl 3-hydroxylase 1", "gene_name": "P3H1", "organism": "Chicken", "refseq_name": "prolyl 3-hydroxylase 1 precursor", "refseq_ac": "NP_001001529", "gene_names_uniprotkb": "P3H1; LEPRE1", "gene_names_refseq": "LEPRE1; P3H1", "protein_names_uniprotkb": "Prolyl 3-hydroxylase 1; 1.14.11.7; Leprecan-1 homolog; Leucine- and proline-enriched proteoglycan 1 homolog", "protein_names_refseq": "leprecan 1; leprecan-1 homolog; leucine proline-enriched proteoglycan (leprecan) 1; leucine- and proline-enriched proteoglycan 1 homolog; prolyl 3-hydroxylase 1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:414142); (R-GGA-1650814)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15044469;24043621", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY463528.1, SRR13267659.45659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000329.1. On Aug 30, 2004 this sequence version replaced XP_417657.1., [RefSeq]; An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro., [RefSeq, PubMed]; Has prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen trimers. May be involved in the secretoty pathway of cells. Has growth suppressive activity in fibroblasts., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.7;5.2.1.8", "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0019797 procollagen-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0032991 protein-containing complex", "go_biological_process": "GO:1901874 negative regulation of post-translational protein modification;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0050708 regulation of protein secretion;GO:0060348 bone development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6JHU8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6PZ02-1", "uniprot_id": "ATG4B_CHICK", "mass": 44531.0, "length": 393, "protein_name": "Cysteine protease ATG4B", "gene_name": "ATG4B", "organism": "Chicken", "refseq_name": "cysteine protease ATG4B isoform 1", "refseq_ac": "NP_998738", "gene_names_uniprotkb": "ATG4B; APG4B; AUT2B; RCJMB04_12m14", "gene_names_refseq": "APG4B; ATG4B", "protein_names_uniprotkb": "Cysteine protease ATG4B; 3.4.22.-; Autophagin-2B; Autophagy-related cysteine endopeptidase 2B; Autophagy-related protein 4 homolog B; cAut2B", "protein_names_refseq": "APG4 autophagy 4 homolog B; ATG4 autophagy related 4 homolog B; AUT2B; autophagin-2B; autophagy-related cysteine endopeptidase 2B; autophagy-related protein 4 homolog B; cAut2B; cysteine protease ATG4B isoform 1; cysteine protease ATG4B", "tax_id": 9031, "disease": "", "pathway": " (gga:404750)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15140988;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01017042.1, SRR13267659.254046.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1., [RefSeq]; Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:15140988). Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Protease activity is also required to counteract formation of high-molecular weight conjugates of ATG8 proteins (ATG8ylation): acts as a deubiquitinating-like enzyme that removes ATG8 conjugated to other proteins, such as ATG3. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZK72", "ec_number_list": "3.4.22.-", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0016485 protein processing;GO:0006914 autophagy;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PZ02-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6XUX0-1", "uniprot_id": "DUSTY_CHICK", "mass": 105410.0, "length": 930, "protein_name": "Dual serine/threonine and tyrosine protein kinase", "gene_name": "DSTYK", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DSTYK; RIPK5", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual serine/threonine and tyrosine protein kinase; 2.7.12.1; Dusty PK; Dusty protein kinase; Receptor-interacting serine/threonine-protein kinase 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395171)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17123648", "class_list": "", "function": "Involved in normal skeletal segmentation and spine formation, via positively regulating late-stage endosomal trafficking in notochord cells (By similarity). May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. Required for normal spatial learning and memory, independent of normal brain development (By similarity). May be required for normal urinary tract and kidney formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.10.2;2.7.10.1;2.7.11.22;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.10.4;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0044344 cellular response to fibroblast growth factor stimulus;GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6XUX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q75R65-1", "uniprot_id": "JAK2_CHICK", "mass": 129847.0, "length": 1129, "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "JAK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase JAK2; 2.7.10.2; JAK-2; Janus kinase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Functionnally, plays a pivotal role in signal transduction and is involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin. Up-regulates the potassium voltage-gated channel activity of KCNA3. Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking proteins for STAT3 (By similarity). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0020037 heme binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0043687 post-translational protein modification;GO:0050867 positive regulation of cell activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q75R65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q76I90-1", "uniprot_id": "NUF2_CHICK", "mass": 55127.0, "length": 469, "protein_name": "Kinetochore protein Nuf2", "gene_name": "NUF2", "organism": "Chicken", "refseq_name": "kinetochore protein Nuf2", "refseq_ac": "NP_989809", "gene_names_uniprotkb": "NUF2; CDCA1; RCJMB04_29i8", "gene_names_refseq": "CDCA1; NUF2", "protein_names_uniprotkb": "Kinetochore protein Nuf2; Cell division cycle-associated protein 1", "protein_names_refseq": "NUF2, NDC80 kinetochore complex component, homolog; cell division cycle associated 1; cell division cycle-associated protein 1; kinetochore protein Nuf2", "tax_id": 9031, "disease": "", "pathway": " (gga:395135)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12829748;15642098;15713649;15870271", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720907.1, SRR13267653.17817.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000237.1. On or before Oct 5, 2021 this sequence version replaced XP_040560418.1, NP_989809.1., [RefSeq]; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12829748). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZI77", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0051301 cell division;GO:0045132 meiotic chromosome segregation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q76I90-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7T2T1-1", "uniprot_id": "CELF2_CHICK", "mass": 51581.0, "length": 484, "protein_name": "CUGBP Elav-like family member 2", "gene_name": "CELF2", "organism": "Chicken", "refseq_name": "CUGBP Elav-like family member 2", "refseq_ac": "NP_989591", "gene_names_uniprotkb": "CELF2; CUGBP2", "gene_names_refseq": "CELF2; CUGBP2", "protein_names_uniprotkb": "CUGBP Elav-like family member 2; Bruno-like protein 3; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; ELAV-type RNA-binding protein 3; ETR-3; RNA-binding protein BRUNOL-3", "protein_names_refseq": "CELF-2; CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; CUGBP Elav-like family member 2; ELAV-type RNA-binding protein 3; RNA-binding protein BRUNOL-3; bruno-like protein 3", "tax_id": 9031, "disease": "", "pathway": " (gga:374111)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15226369;15830352;23468433", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: AY288985.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ452898.1, AY288985.1 and BU297367.1. On Dec 12, 2014 this sequence version replaced NP_989591.1., [RefSeq]; CELF1 and CELF2 may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos, [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation repression and stability. Mediates exon inclusion in TNNT2 pre-mRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T2T0", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0042835 BRE binding;GO:0003723 RNA binding;GO:0000166 nucleotide binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006376 mRNA splice site recognition;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7T2T1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7ZT11-1", "uniprot_id": "ANKR1_CHICK", "mass": 36273.0, "length": 319, "protein_name": "Ankyrin repeat domain-containing protein 1", "gene_name": "ANKRD1", "organism": "Chicken", "refseq_name": "ankyrin repeat domain-containing protein 1", "refseq_ac": "NP_989736", "gene_names_uniprotkb": "ANKRD1; CARP", "gene_names_refseq": "ALRP; ANKRD1; CARP", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 1; Cardiac ankyrin repeat protein", "protein_names_refseq": "ankyrin repeat domain 1 (cardiac muscle); ankyrin repeat domain-containing protein 1; ankyrin-like repeat protein; cardiac ankyrin repeat protein", "tax_id": 9031, "disease": "", "pathway": " (gga:378926)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB082935.1, AB082934.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992323, SAMEA103992415 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000231.1. On Sep 29, 2021 this sequence version replaced NP_989736.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7ZT11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AWC3-1", "uniprot_id": "ARC_CHICK", "mass": 46307.0, "length": 404, "protein_name": "Activity-regulated cytoskeleton-associated protein", "gene_name": "ARC", "organism": "Chicken", "refseq_name": "activity-regulated cytoskeleton-associated protein", "refseq_ac": "NP_989763", "gene_names_uniprotkb": "ARC", "gene_names_refseq": "ARC; ARG3.1", "protein_names_uniprotkb": "Activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog; Arg3.1", "protein_names_refseq": "ARC/ARG3.1; activity-regulated cytoskeleton-associated protein; activity-regulated gene 3.1 protein homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:395075)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15908132", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AJ272062.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ272062.1., [RefSeq]; Both the Arc/arg3.1 and zenk genes are induced by auditory imprinting, they are significantly up-regulated in different learning-relevant brain regions, [RefSeq, PubMed]; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0110077 vesicle-mediated intercellular transport;GO:0006897 endocytosis;GO:0051260 protein homooligomerization;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AWC3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AXY6-1", "uniprot_id": "MUSK_CHICK", "mass": 105589.0, "length": 947, "protein_name": "Muscle, skeletal receptor tyrosine protein kinase", "gene_name": "MUSK", "organism": "Chicken", "refseq_name": "muscle, skeletal receptor tyrosine protein kinase precursor", "refseq_ac": "NP_989439", "gene_names_uniprotkb": "MUSK", "gene_names_refseq": "MUSK", "protein_names_uniprotkb": "Muscle, skeletal receptor tyrosine protein kinase; 2.7.10.1; MuSK; Muscle-specific kinase receptor; Muscle-specific tyrosine protein kinase receptor", "protein_names_refseq": "muscle, skeletal receptor tyrosine protein kinase precursor; muscle, skeletal receptor tyrosine protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific tyrosine protein kinase receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:373897)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11083926", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY143173.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000095.1. On Dec 7, 2021 this sequence version replaced NP_989439.1., [RefSeq]; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May also play a role in acetylcholinesterase (AChE) localization at the neuromuscular junctions (NMJ) via its interaction wit COLQ (By similarity). May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0017147 Wnt-protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007528 neuromuscular junction development;GO:0030154 cell differentiation;GO:0010604 positive regulation of macromolecule metabolic process;GO:0008582 regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AXY6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8AYS8-1", "uniprot_id": "KCMA1_CHICK", "mass": 127647.0, "length": 1137, "protein_name": "Calcium-activated potassium channel subunit alpha-1", "gene_name": "KCNMA1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KCNMA1; KCNMA", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog; cSlo", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374065)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10362660;8755483;9178544;9390519;9543635;9880252", "class_list": "", "function": "Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O12942;O13110;O93569;Q98951;Q9PS76", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015269 calcium-activated potassium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0060072 large conductance calcium-activated potassium channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8AYS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYC7-1", "uniprot_id": "A0A8V0XYC7_CHICK", "mass": 68504.0, "length": 591, "protein_name": "Intraflagellar transport 74", "gene_name": "IFT74", "organism": "Chicken", "refseq_name": "intraflagellar transport protein 74 homolog", "refseq_ac": "XP_003643118", "gene_names_uniprotkb": "IFT74", "gene_names_refseq": "IFT74", "protein_names_uniprotkb": "Intraflagellar transport 74", "protein_names_refseq": "intraflagellar transport protein 74 homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:427367); (R-GGA-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_003643118.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048487 beta-tubulin binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005929 cilium;GO:0030992 intraciliary transport particle B;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0034451 centriolar satellite", "go_biological_process": "GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0035735 intraciliary transport involved in cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYC7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYE4-1", "uniprot_id": "A0A8V0XYE4_CHICK", "mass": 157381.0, "length": 1388, "protein_name": "MIA SH3 domain ER export factor 2", "gene_name": "MIA2", "organism": "Chicken", "refseq_name": "melanoma inhibitory activity protein 2 isoform X1", "refseq_ac": "XP_004941833", "gene_names_uniprotkb": "MIA2", "gene_names_refseq": "MIA2", "protein_names_uniprotkb": "MIA SH3 domain ER export factor 2", "protein_names_refseq": "melanoma inhibitory activity protein 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:423339); (R-GGA-5694530)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004941833.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0035459 vesicle cargo loading", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYE4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYJ9-1", "uniprot_id": "A0A8V0XYJ9_CHICK", "mass": 49965.0, "length": 449, "protein_name": "SPARC related modular calcium binding 2", "gene_name": "SMOC2", "organism": "Chicken", "refseq_name": "SPARC-related modular calcium-binding protein 2 isoform X3", "refseq_ac": "XP_004935572", "gene_names_uniprotkb": "SMOC2", "gene_names_refseq": "SMOC2", "protein_names_uniprotkb": "SPARC related modular calcium binding 2", "protein_names_refseq": "SPARC-related modular calcium-binding protein 2 isoform X3", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004935572.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008201 heparin binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005604 basement membrane", "go_biological_process": "GO:0035470 positive regulation of vascular wound healing;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0030198 extracellular matrix organization;GO:0045931 positive regulation of mitotic cell cycle;GO:2000573 positive regulation of DNA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYP0-1", "uniprot_id": "A0A8V0XYP0_CHICK", "mass": 56395.0, "length": 498, "protein_name": "Tetratricopeptide repeat protein 29", "gene_name": "TTC29", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TTC29", "gene_names_refseq": "", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 29", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Axonemal protein which is implicated in axonemal and/or peri-axonemal structure assembly and regulates flagellum assembly and beating and therefore sperm motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece", "go_biological_process": "GO:0003341 cilium movement;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYP0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZG4-1", "uniprot_id": "A0A8V0XZG4_CHICK", "mass": 28957.0, "length": 257, "protein_name": "Carbonic anhydrase", "gene_name": "CA7", "organism": "Chicken", "refseq_name": "carbonic anhydrase 7 isoform X2", "refseq_ac": "XP_040501875", "gene_names_uniprotkb": "CA7", "gene_names_refseq": "CA7", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 7 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1475029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.1;4.2.1.69", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZG4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XX04-1", "uniprot_id": "A0A8V0XX04_CHICK", "mass": 48556.0, "length": 434, "protein_name": "Glutaminyl-peptide cyclotransferase", "gene_name": "QPCT", "organism": "Chicken", "refseq_name": "glutaminyl-peptide cyclotransferase isoform X1", "refseq_ac": "XP_025005069", "gene_names_uniprotkb": "QPCT", "gene_names_refseq": "QPCT", "protein_names_uniprotkb": "Glutaminyl-peptide cyclotransferase; 2.3.2.5; Glutaminyl cyclase; Glutaminyl-tRNA cyclotransferase", "protein_names_refseq": "glutaminyl-peptide cyclotransferase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6798695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_025005069.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.186;2.7.11.24;1.11.1.24;3.4.21.4;2.3.3.8;3.2.1.31;3.1.3.48;4.1.2.13;3.4.19.9;3.2.1.166;3.4.22.52;3.6.4.13;3.5.1.3;2.3.2.5;5.3.1.9;1.8.3.2;3.4.22.1;2.7.1.1;3.3.2.6;4.2.99.18;5.6.2.4;2.7.1.35;2.3.2.27;3.6.4.6;4.1.2.4;2.7.10.2;3.4.24.35;5.2.1.8;3.2.1.23;2.4.1.1;5.4.2.11;5.4.2.4;3.5.4.5;2.7.1.40;3.6.5.2;3.4.21.41;1.1.1.42;2.4.1.25;3.2.1.33;3.1.1.47;2.7.1.11;1.11.1.6;1.13.11.34;3.4.19.1;5.3.2.1;5.3.3.12;1.4.3.-;4.2.1.24;3.6.1.6;3.4.24.7;3.5.4.6;3.1.6.14;5.4.2.2;2.7.4.6;3.2.1.17;1.16.3.1;3.4.23.5;5.3.99.2;3.6.5.-;3.5.1.23", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016603 glutaminyl-peptide cyclotransferase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XX04-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y081-1", "uniprot_id": "A0A8V0Y081_CHICK", "mass": 87275.0, "length": 789, "protein_name": "Cadherin 11", "gene_name": "CDH11", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CDH11", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin 11", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-418990); (R-GGA-9762292); (R-GGA-9958825)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016477 cell migration;GO:0030336 negative regulation of cell migration;GO:0000902 cell morphogenesis;GO:0048041 focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y081-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0C4-1", "uniprot_id": "A0A8V0Y0C4_CHICK", "mass": 77977.0, "length": 693, "protein_name": "Cell cycle checkpoint protein RAD17", "gene_name": "RAD17", "organism": "Chicken", "refseq_name": "cell cycle checkpoint protein RAD17 isoform X1", "refseq_ac": "XP_015136086", "gene_names_uniprotkb": "RAD17", "gene_names_refseq": "RAD17", "protein_names_uniprotkb": "Cell cycle checkpoint protein RAD17", "protein_names_refseq": "cell cycle checkpoint protein RAD17 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-176187); (R-GGA-5685938); (R-GGA-5693607)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015136086.1. COMPLETENESS: full length., [RefSeq]; Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation. Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites. May also serve as a sensor of DNA replication progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0003689 DNA clamp loader activity;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031389 Rad17 RFC-like complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0000077 DNA damage checkpoint signaling;GO:1990166 protein localization to site of double-strand break;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0008156 negative regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0C4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXE0-1", "uniprot_id": "A0A8V0XXE0_CHICK", "mass": 33014.0, "length": 286, "protein_name": "Inhibitor of growth protein", "gene_name": "ING2", "organism": "Chicken", "refseq_name": "inhibitor of growth protein 2", "refseq_ac": "XP_015132033", "gene_names_uniprotkb": "ING2", "gene_names_refseq": "ING2", "protein_names_uniprotkb": "Inhibitor of growth protein", "protein_names_refseq": "inhibitor of growth protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:422553); (R-GGA-3899300); (R-GGA-6811555)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015132033.1. COMPLETENESS: full length., [RefSeq]; Component of an histone acetyltransferase complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003677 DNA binding;GO:0044877 protein-containing complex binding;GO:0035091 phosphatidylinositol binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0070822 Sin3-type complex;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0006325 chromatin organization;GO:0048133 male germ-line stem cell asymmetric division;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXS0-1", "uniprot_id": "A0A8V0XXS0_CHICK", "mass": 131906.0, "length": 1168, "protein_name": "Transcriptional repressor NF-X1", "gene_name": "NFX1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NFX1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcriptional repressor NF-X1; Nuclear transcription factor, X box-binding protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0016740 transferase activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXS0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXT6-1", "uniprot_id": "A0A8V0XXT6_CHICK", "mass": 29343.0, "length": 265, "protein_name": "Ras-related protein Rab", "gene_name": "RAB38", "organism": "Chicken", "refseq_name": "ras-related protein Rab-38", "refseq_ac": "XP_015135839", "gene_names_uniprotkb": "RAB38", "gene_names_refseq": "RAB38", "protein_names_uniprotkb": "Ras-related protein Rab", "protein_names_refseq": "ras-related protein Rab-38", "tax_id": 9031, "disease": "", "pathway": " (gga:428095)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015135839.2. COMPLETENESS: full length., [RefSeq]; The small GTPases Rab are key regulators in vesicle trafficking., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0035651 AP-3 adaptor complex binding;GO:0036461 BLOC-2 complex binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0016020 membrane;GO:0031982 vesicle;GO:0005802 trans-Golgi network;GO:0005739 mitochondrion;GO:0005769 early endosome", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:1903232 melanosome assembly;GO:0090383 phagosome acidification;GO:0008333 endosome to lysosome transport;GO:0035646 endosome to melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXT6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y128-1", "uniprot_id": "A0A8V0Y128_CHICK", "mass": 48923.0, "length": 431, "protein_name": "Pachytene checkpoint protein 2 homolog", "gene_name": "TRIP13", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TRIP13", "gene_names_refseq": "", "protein_names_uniprotkb": "Pachytene checkpoint protein 2 homolog; TR-interacting protein 13; TRIP-13; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001673 male germ cell nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0048477 oogenesis;GO:0007131 reciprocal meiotic recombination;GO:0051598 meiotic recombination checkpoint signaling;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y128-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXJ4-1", "uniprot_id": "A0A8V0XXJ4_CHICK", "mass": 62085.0, "length": 539, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3", "gene_name": "PFKFB3", "organism": "Chicken", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X2", "refseq_ac": "XP_046765114", "gene_names_uniprotkb": "PFKFB3", "gene_names_refseq": "PFKFB3", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3", "protein_names_refseq": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9634600)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003873 6-phosphofructo-2-kinase activity;GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXJ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZB0-1", "uniprot_id": "A0A8V0XZB0_CHICK", "mass": 508033.0, "length": 4612, "protein_name": "Protocadherin Fat 3", "gene_name": "FAT3", "organism": "Chicken", "refseq_name": "protocadherin Fat 3 isoform X1", "refseq_ac": "XP_015135313", "gene_names_uniprotkb": "FAT3", "gene_names_refseq": "FAT3", "protein_names_uniprotkb": "Protocadherin Fat 3; FAT tumor suppressor homolog 3", "protein_names_refseq": "protocadherin Fat 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015135313.1. COMPLETENESS: full length., [RefSeq]; May play a role in the interactions between neurites derived from specific subsets of neurons during development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0005912 adherens junction;GO:0030425 dendrite", "go_biological_process": "GO:0016358 dendrite development;GO:0001764 neuron migration;GO:0009887 animal organ morphogenesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048646 anatomical structure formation involved in morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZX7-1", "uniprot_id": "A0A8V0XZX7_CHICK", "mass": 92809.0, "length": 835, "protein_name": "Phosphatidylinositol-glycan-specific phospholipase D", "gene_name": "GPLD1", "organism": "Chicken", "refseq_name": "phosphatidylinositol-glycan-specific phospholipase D", "refseq_ac": "XP_418910", "gene_names_uniprotkb": "GPLD1", "gene_names_refseq": "GPLD1", "protein_names_uniprotkb": "Phosphatidylinositol-glycan-specific phospholipase D; 3.1.4.50; Glycosyl-phosphatidylinositol-specific phospholipase D", "protein_names_refseq": "phosphatidylinositol-glycan-specific phospholipase D", "tax_id": 9031, "disease": "", "pathway": " (gga:420819); (R-GGA-163125)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_418910.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.31;3.1.4.50;3.2.2.6;3.4.11.9;3.1.3.1;2.7.11.1", "go_molecular_function": "GO:0004621 glycosylphosphatidylinositol phospholipase D activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0071401 cellular response to triglyceride;GO:1900076 regulation of cellular response to insulin stimulus;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZX7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYT1-1", "uniprot_id": "A0A8V0XYT1_CHICK", "mass": 80883.0, "length": 712, "protein_name": "GRAM domain containing 1C", "gene_name": "GRAMD1C", "organism": "Chicken", "refseq_name": "protein Aster-C isoform X1", "refseq_ac": "XP_015150859", "gene_names_uniprotkb": "GRAMD1C", "gene_names_refseq": "GRAMD1C", "protein_names_uniprotkb": "GRAM domain containing 1C", "protein_names_refseq": "protein Aster-C isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418354)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015150859.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane;GO:0005886 plasma membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0071397 cellular response to cholesterol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYT1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ11-1", "uniprot_id": "A0A8V0XZ11_CHICK", "mass": 57398.0, "length": 520, "protein_name": "Signal recognition particle 54 kDa protein", "gene_name": "SRP54", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SRP54", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal recognition particle 54 kDa protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1799339)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008312 7S RNA binding;GO:0030942 endoplasmic reticulum signal peptide binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005783 endoplasmic reticulum;GO:0016607 nuclear speck;GO:0005829 cytosol", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0030851 granulocyte differentiation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ11-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ74-1", "uniprot_id": "A0A8V0XZ74_CHICK", "mass": 13319.0, "length": 121, "protein_name": "Protein kish-A", "gene_name": "TMEM167A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TMEM167A", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein kish-A; Transmembrane protein 167A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the early part of the secretory pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ74-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZF4-1", "uniprot_id": "A0A8V0XZF4_CHICK", "mass": 226799.0, "length": 2119, "protein_name": "Kinesin family member 26B", "gene_name": "KIF26B", "organism": "Chicken", "refseq_name": "kinesin-like protein KIF26B", "refseq_ac": "XP_003641032", "gene_names_uniprotkb": "KIF26B", "gene_names_refseq": "KIF26B", "protein_names_uniprotkb": "Kinesin family member 26B", "protein_names_refseq": "kinesin-like protein KIF26B", "tax_id": 9031, "disease": "", "pathway": " (gga:100859813); (R-GGA-6811434); (R-GGA-983189)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_003641032.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:0048731 system development;GO:0007018 microtubule-based movement;GO:0072092 ureteric bud invasion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XY25-1", "uniprot_id": "A0A8V0XY25_CHICK", "mass": 161419.0, "length": 1410, "protein_name": "Cell division cycle 5 like", "gene_name": "CDC5L", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CDC5L", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell division cycle 5 like", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-72163)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0000974 Prp19 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006355 regulation of DNA-templated transcription;GO:0000398 mRNA splicing, via spliceosome;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XY25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XY40-1", "uniprot_id": "A0A8V0XY40_CHICK", "mass": 77390.0, "length": 679, "protein_name": "Arginine--tRNA ligase, cytoplasmic", "gene_name": "RARS", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RARS", "gene_names_refseq": "", "protein_names_uniprotkb": "Arginine--tRNA ligase, cytoplasmic; 6.1.1.19; Arginyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9856649)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.15;6.1.1.17;6.1.1.19;2.8.2.-;6.1.1.6;6.1.1.4;6.1.1.18;2.7.11.24;6.1.1.5;2.7.10.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0004814 arginine-tRNA ligase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex;GO:0005634 nucleus", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XY40-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XWS3-1", "uniprot_id": "A0A8V0XWS3_CHICK", "mass": 81082.0, "length": 792, "protein_name": "POU domain protein", "gene_name": "POU2F1", "organism": "Chicken", "refseq_name": "POU domain, class 2, transcription factor 1 isoform X1", "refseq_ac": "XP_040526415", "gene_names_uniprotkb": "POU2F1", "gene_names_refseq": "Oct-1; POU2F1; chOCT-1", "protein_names_uniprotkb": "POU domain protein", "protein_names_refseq": "POU domain, class 2, transcription factor 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6807505); (R-GGA-76071); (R-GGA-9018519)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XWS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0Q7-1", "uniprot_id": "A0A8V0Y0Q7_CHICK", "mass": 35309.0, "length": 317, "protein_name": "E3 ubiquitin-protein ligase RNF144B", "gene_name": "RNF144B", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RNF144B", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF144B; 2.3.2.31; RING finger protein 144B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420827); (R-GGA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.23;2.3.2.27;2.3.2.26;2.3.2.24;2.3.2.31;2.7.11.1;6.2.1.45;2.3.2.34", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006915 apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0Q7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ75-1", "uniprot_id": "A0A8V0XZ75_CHICK", "mass": 47839.0, "length": 417, "protein_name": "m7GpppN-mRNA hydrolase", "gene_name": "DCP2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DCP2", "gene_names_refseq": "", "protein_names_uniprotkb": "m7GpppN-mRNA hydrolase; 3.6.1.62; mRNA-decapping enzyme 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-430039); (R-GGA-450385)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.1.62;3.6.4.13", "go_molecular_function": "GO:0003723 RNA binding;GO:0030145 manganese ion binding;GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity;GO:0004534 5'-3' RNA exonuclease activity;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0005737 cytoplasm;GO:0016442 RISC complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0071044 histone mRNA catabolic process;GO:1904872 regulation of telomerase RNA localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZF6-1", "uniprot_id": "A0A8V0XZF6_CHICK", "mass": 68494.0, "length": 634, "protein_name": "Solute carrier family 23 member 1", "gene_name": "SLC23A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC23A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 23 member 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:416188); (R-GGA-196836)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0008520 L-ascorbate:sodium symporter activity;GO:0015229 L-ascorbic acid transmembrane transporter activity;GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015882 L-ascorbic acid transmembrane transport;GO:0030324 lung development;GO:0007420 brain development;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XY23-1", "uniprot_id": "A0A8V0XY23_CHICK", "mass": 59802.0, "length": 526, "protein_name": "Lysophosphatidylcholine acyltransferase 1", "gene_name": "LPCAT1", "organism": "Chicken", "refseq_name": "lysophosphatidylcholine acyltransferase 1 isoform X2", "refseq_ac": "XP_040519252", "gene_names_uniprotkb": "LPCAT1", "gene_names_refseq": "LPCAT1", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 1", "protein_names_refseq": "lysophosphatidylcholine acyltransferase 1 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:420974); (R-GGA-1482788); (R-GGA-1482925); (R-GGA-1483166); (R-GGA-6798695)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0047159 plasmalogen synthase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0036151 phosphatidylcholine acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XY23-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZM3-1", "uniprot_id": "A0A8V0XZM3_CHICK", "mass": 85427.0, "length": 746, "protein_name": "Histone-lysine N-methyltransferase EZH2", "gene_name": "EZH2", "organism": "Chicken", "refseq_name": "histone-lysine N-methyltransferase EZH2 isoform X5", "refseq_ac": "XP_004935119", "gene_names_uniprotkb": "EZH2", "gene_names_refseq": "EZH2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase EZH2; 2.1.1.356", "protein_names_refseq": "histone-lysine N-methyltransferase EZH2 isoform X5", "tax_id": 9031, "disease": "", "pathway": " (gga:420784); (R-GGA-212300); (R-GGA-2559580); (R-GGA-8943724); (R-GGA-8953750); (R-GGA-9764725); (R-GGA-9909649)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;2.1.1.367;2.1.1.356;2.1.1.37", "go_molecular_function": "GO:0140951 histone H3K27 trimethyltransferase activity;GO:0003682 chromatin binding;GO:0043021 ribonucleoprotein complex binding;GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0005677 chromatin silencing complex;GO:0045120 pronucleus;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0048511 rhythmic process;GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZA9-1", "uniprot_id": "A0A8V0XZA9_CHICK", "mass": 95600.0, "length": 852, "protein_name": "Heat shock protein 105 kDa", "gene_name": "HSPH1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSPH1", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock protein 105 kDa; Heat shock 110 kDa protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043014 alpha-tubulin binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051135 positive regulation of NK T cell activation;GO:0006986 response to unfolded protein;GO:0045345 positive regulation of MHC class I biosynthetic process;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1J6-1", "uniprot_id": "A0A8V0Y1J6_CHICK", "mass": 81160.0, "length": 728, "protein_name": "Zinc transporter ZIP6", "gene_name": "SLC39A6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC39A6", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc transporter ZIP6; Solute carrier family 39 member 6; Zrt- and Irt-like protein 6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420984); (R-GGA-442380)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0046873 metal ion transmembrane transporter activity;GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0046649 lymphocyte activation;GO:0050852 T cell receptor signaling pathway;GO:0001837 epithelial to mesenchymal transition;GO:0006882 intracellular zinc ion homeostasis;GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1J6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYH3-1", "uniprot_id": "A0A8V0XYH3_CHICK", "mass": 56674.0, "length": 513, "protein_name": "Angiotensinogen", "gene_name": "AGT", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AGT", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiotensinogen; Serpin A8", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2022377); (R-GGA-375276); (R-GGA-416476); (R-GGA-418594)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stimulates aldosterone release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031702 type 1 angiotensin receptor binding;GO:0031703 type 2 angiotensin receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin;GO:0042310 vasoconstriction;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001822 kidney development;GO:0010595 positive regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYH3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y064-1", "uniprot_id": "A0A8V0Y064_CHICK", "mass": 32963.0, "length": 299, "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "IGFBP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-381426); (R-GGA-8957275)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding;GO:0005520 insulin-like growth factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XX25-1", "uniprot_id": "A0A8V0XX25_CHICK", "mass": 74509.0, "length": 666, "protein_name": "Zinc transporter ZIP12", "gene_name": "SLC39A12", "organism": "Chicken", "refseq_name": "zinc transporter ZIP12 isoform X4", "refseq_ac": "XP_046793863", "gene_names_uniprotkb": "SLC39A12", "gene_names_refseq": "SLC39A12", "protein_names_uniprotkb": "Zinc transporter ZIP12; Solute carrier family 39 member 12; Zrt- and Irt-like protein 12", "protein_names_refseq": "zinc transporter ZIP12 isoform X4", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0046873 metal ion transmembrane transporter activity;GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030003 intracellular monoatomic cation homeostasis;GO:0071578 zinc ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XX25-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYS4-1", "uniprot_id": "A0A8V0XYS4_CHICK", "mass": 132098.0, "length": 1167, "protein_name": "CWF19-like protein 1", "gene_name": "CWF19L1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CWF19L1", "gene_names_refseq": "", "protein_names_uniprotkb": "CWF19-like protein 1; 2.7.11.10; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Nuclear factor NF-kappa-B inhibitor kinase alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1169091); (R-GGA-1810476); (R-GGA-198323); (R-GGA-202424); (R-GGA-2871837); (R-GGA-445989); (R-GGA-5357905); (R-GGA-5607761); (R-GGA-5607764); (R-GGA-5676590); (R-GGA-5684264); (R-GGA-933542); (R-GGA-937041); (R-GGA-9758274); (R-GGA-9833482); (R-GGA-9860276); (R-GGA-9860927); (R-GGA-9909505)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.13;3.4.19.12;2.7.11.10;5.2.1.8;2.3.2.27", "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0005524 ATP binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0008385 IkappaB kinase complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYS4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYS9-1", "uniprot_id": "A0A8V0XYS9_CHICK", "mass": 15685.0, "length": 140, "protein_name": "Histone H2B", "gene_name": "HIST1H2B5L", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HIST1H2B5L", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H2B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:429558); (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-3214847); (R-GGA-427413); (R-GGA-5250924); (R-GGA-5689880); (R-GGA-5693565); (R-GGA-5693571); (R-GGA-5693607); (R-GGA-606279); (R-GGA-68616); (R-GGA-69473); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 27, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYS9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XX93-1", "uniprot_id": "A0A8V0XX93_CHICK", "mass": 218736.0, "length": 1922, "protein_name": "Coagulation factor V", "gene_name": "F5", "organism": "Chicken", "refseq_name": "coagulation factor V isoform X1", "refseq_ac": "XP_001231901", "gene_names_uniprotkb": "F5", "gene_names_refseq": "F5", "protein_names_uniprotkb": "Coagulation factor V", "protein_names_refseq": "coagulation factor V isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:374052); (R-GGA-114608); (R-GGA-204005); (R-GGA-381426); (R-GGA-5694530); (R-GGA-8957275); (R-GGA-9769735); (R-GGA-9769739); (R-GGA-9769743)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_001231901.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0007596 blood coagulation;GO:0008015 blood circulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XX93-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y099-1", "uniprot_id": "A0A8V0Y099_CHICK", "mass": 46678.0, "length": 416, "protein_name": "Regulator of microtubule dynamics protein 2", "gene_name": "RMDN2", "organism": "Chicken", "refseq_name": "regulator of microtubule dynamics protein 2 isoform X2", "refseq_ac": "XP_015139238", "gene_names_uniprotkb": "RMDN2", "gene_names_refseq": "RMDN2", "protein_names_uniprotkb": "Regulator of microtubule dynamics protein 2; Protein FAM82A1", "protein_names_refseq": "regulator of microtubule dynamics protein 2 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:421465)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015139238.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0005876 spindle microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0T3-1", "uniprot_id": "A0A8V0Y0T3_CHICK", "mass": 37447.0, "length": 334, "protein_name": "GDP-L-fucose synthase", "gene_name": "TSTA3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TSTA3", "gene_names_refseq": "", "protein_names_uniprotkb": "GDP-L-fucose synthase; 1.1.1.271; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; Protein FX; Red cell NADP(H)-binding protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6787639)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.271", "go_molecular_function": "GO:0050577 GDP-L-fucose synthase activity;GO:0047918 GDP-mannose 3,5-epimerase activity;GO:0042802 identical protein binding;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0010595 positive regulation of endothelial cell migration;GO:1904906 positive regulation of endothelial cell-matrix adhesion via fibronectin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0T3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYW7-1", "uniprot_id": "A0A8V0XYW7_CHICK", "mass": 59707.0, "length": 527, "protein_name": "Eva-1 homolog A, regulator of programmed cell death", "gene_name": "EVA1A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EVA1A", "gene_names_refseq": "", "protein_names_uniprotkb": "Eva-1 homolog A, regulator of programmed cell death", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422065)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006914 autophagy;GO:0031929 TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y121-1", "uniprot_id": "A0A8V0Y121_CHICK", "mass": 78049.0, "length": 678, "protein_name": "Lysine--tRNA ligase", "gene_name": "CHST4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHST4", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine--tRNA ligase; 6.1.1.6; Lysyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:427567); (R-GGA-9856649)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.15;6.1.1.17;6.1.1.19;2.8.2.-;6.1.1.6;6.1.1.4;6.1.1.18;2.7.11.24;6.1.1.5;2.7.10.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0003676 nucleic acid binding;GO:0016740 transferase activity;GO:0004824 lysine-tRNA ligase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0006430 lysyl-tRNA aminoacylation;GO:0043032 positive regulation of macrophage activation;GO:0015966 diadenosine tetraphosphate biosynthetic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0070371 ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZG0-1", "uniprot_id": "A0A8V0XZG0_CHICK", "mass": 81188.0, "length": 701, "protein_name": "1,4-alpha-glucan branching enzyme", "gene_name": "GBE1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GBE1", "gene_names_refseq": "", "protein_names_uniprotkb": "1,4-alpha-glucan branching enzyme; 2.4.1.18", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3322077)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.186;2.4.1.18;2.4.1.11", "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0003844 1,4-alpha-glucan branching enzyme activity;GO:0043169 cation binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZG0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0R2-1", "uniprot_id": "A0A8V0Y0R2_CHICK", "mass": 87889.0, "length": 800, "protein_name": "Striatin", "gene_name": "STRN", "organism": "Chicken", "refseq_name": "striatin isoform X3", "refseq_ac": "XP_419519", "gene_names_uniprotkb": "STRN", "gene_names_refseq": "STRN", "protein_names_uniprotkb": "Striatin", "protein_names_refseq": "striatin isoform X3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1257604); (R-GGA-6811558); (R-GGA-9009391)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_419519.4. COMPLETENESS: full length., [RefSeq]; Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051721 protein phosphatase 2A binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0043197 dendritic spine;GO:0032991 protein-containing complex;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0016055 Wnt signaling pathway;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1W6-1", "uniprot_id": "A0A8V0Y1W6_CHICK", "mass": 109727.0, "length": 958, "protein_name": "Aminopeptidase", "gene_name": "LVRN", "organism": "Chicken", "refseq_name": "aminopeptidase Q isoform X2", "refseq_ac": "XP_046793181", "gene_names_uniprotkb": "LVRN", "gene_names_refseq": "LVRN", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "aminopeptidase Q isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:431649)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_059536) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1W6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y070-1", "uniprot_id": "A0A8V0Y070_CHICK", "mass": 119532.0, "length": 1049, "protein_name": "Metalloendopeptidase", "gene_name": "TLL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TLL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Metalloendopeptidase; 3.4.24.-", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395441)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y070-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0C2-1", "uniprot_id": "A0A8V0Y0C2_CHICK", "mass": 33590.0, "length": 298, "protein_name": "Endoplasmic reticulum-Golgi intermediate compartment protein", "gene_name": "ERGIC1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ERGIC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Endoplasmic reticulum-Golgi intermediate compartment protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:416205)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in transport between endoplasmic reticulum and Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0C2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYR4-1", "uniprot_id": "A0A8V0XYR4_CHICK", "mass": 80499.0, "length": 710, "protein_name": "Guanylate cyclase soluble subunit alpha-1", "gene_name": "GUCY1A3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GUCY1A3", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit alpha-1; 4.6.1.2; Soluble guanylate cyclase large subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-445355)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.2", "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0008074 guanylate cyclase complex, soluble", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006182 cGMP biosynthetic process;GO:0038060 nitric oxide-cGMP-mediated signaling;GO:0098925 retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYR4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XY10-1", "uniprot_id": "A0A8V0XY10_CHICK", "mass": 29632.0, "length": 289, "protein_name": "hydroxyisourate hydrolase", "gene_name": "URAH", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "URAH", "gene_names_refseq": "", "protein_names_uniprotkb": "hydroxyisourate hydrolase; 3.5.2.17", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.2.17", "go_molecular_function": "GO:0033971 hydroxyisourate hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006144 purine nucleobase metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XY10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZA0-1", "uniprot_id": "A0A8V0XZA0_CHICK", "mass": 44331.0, "length": 385, "protein_name": "Neuropeptide Y receptor type 1", "gene_name": "NPY1R", "organism": "Chicken", "refseq_name": "neuropeptide Y receptor type 1", "refseq_ac": "NP_001026706", "gene_names_uniprotkb": "NPY1R", "gene_names_refseq": "NPY1R", "protein_names_uniprotkb": "Neuropeptide Y receptor type 1", "protein_names_refseq": "G-protein coupled receptor; neuropeptide Y receptor type 1", "tax_id": 9031, "disease": "", "pathway": " (gga:428727); (R-GGA-375276); (R-GGA-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "30444128", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: ERR2286007.67323.1, SRR12888496.187485.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1. On or before Dec 15, 2021 this sequence version replaced XP_015140792.2, NP_001026706.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; The results of the present study indicated that somatostatin-induced hyperphagia may be modulated by the NPY1 receptor (not the NPY2 and NPY5 receptors) in neonatal chicks., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004983 neuropeptide Y receptor activity;GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0003151 outflow tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8V0XZA0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZK8-1", "uniprot_id": "A0A8V0XZK8_CHICK", "mass": 39620.0, "length": 345, "protein_name": "Centromere protein U", "gene_name": "CENPU", "organism": "Chicken", "refseq_name": "centromere protein U", "refseq_ac": "NP_001034388", "gene_names_uniprotkb": "CENPU", "gene_names_refseq": "CENP-50; CENPU; MLF1IP", "protein_names_uniprotkb": "Centromere protein U; MLF1-interacting protein", "protein_names_refseq": "CENP-U; KSHV latent nuclear antigen interacting protein 1; MLF1-interacting protein; centromere protein U; centromere protein of 50 kDa; centromere protein p50", "tax_id": 9031, "disease": "", "pathway": " (gga:422548); (R-GGA-141430); (R-GGA-141444); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-5663220); (R-GGA-606279); (R-GGA-9648025)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01074632.1, AB233421.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000073.1. On Sep 23, 2021 this sequence version replaced NP_001034388.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZK8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYC1-1", "uniprot_id": "A0A8V0XYC1_CHICK", "mass": 26079.0, "length": 240, "protein_name": "Thioredoxin like 4A", "gene_name": "TXNL4A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TXNL4A", "gene_names_refseq": "", "protein_names_uniprotkb": "Thioredoxin like 4A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420811)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)., [UniProtKB, UniProtKB]; Plays role in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005682 U5 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYP2-1", "uniprot_id": "A0A8V0XYP2_CHICK", "mass": 41769.0, "length": 367, "protein_name": "DNA-directed RNA polymerases I and III subunit RPAC1", "gene_name": "POLR1C", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "POLR1C", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-directed RNA polymerases I and III subunit RPAC1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5250924); (R-GGA-73772); (R-GGA-73863)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000428 DNA-directed RNA polymerase complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006362 transcription elongation by RNA polymerase I;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYP2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXA9-1", "uniprot_id": "A0A8V0XXA9_CHICK", "mass": 62301.0, "length": 556, "protein_name": "Glucose-6-phosphate isomerase", "gene_name": "GPI", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GPI", "gene_names_refseq": "", "protein_names_uniprotkb": "Glucose-6-phosphate isomerase; 5.3.1.9", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:415783); (R-GGA-5628897); (R-GGA-6798695); (R-GGA-70171); (R-GGA-70263)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm. Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P. In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. Released by lectin-stimulated T-cells to induce immunoglobulin secretion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.186;2.7.11.24;1.11.1.24;2.3.3.8;3.2.1.31;4.1.2.13;3.4.22.52;3.6.4.13;2.4.2.7;2.3.2.5;5.3.1.9;3.4.22.1;2.7.1.1;3.3.2.6;4.2.99.18;5.6.2.4;2.7.1.35;2.3.2.27;3.6.4.6;4.1.2.4;3.4.24.35;5.2.1.8;3.2.1.23;2.4.1.1;5.4.2.11;5.4.2.4;3.5.4.5;2.7.1.40;1.1.1.42;2.4.1.25;3.2.1.33;3.1.1.47;2.7.1.11;1.11.1.6;1.13.11.34;3.4.19.1;5.3.2.1;5.3.3.12;4.2.1.24;3.6.1.6;3.5.4.6;3.1.6.14;5.4.2.2;2.7.4.6;1.16.3.1;2.7.10.2;3.4.23.5;3.6.5.-;3.5.1.23", "go_molecular_function": "GO:0004347 glucose-6-phosphate isomerase activity;GO:0097367 carbohydrate derivative binding;GO:0031625 ubiquitin protein ligase binding;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0051156 glucose 6-phosphate metabolic process;GO:0010595 positive regulation of endothelial cell migration;GO:0002639 positive regulation of immunoglobulin production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXA9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ08-1", "uniprot_id": "A0A8V0XZ08_CHICK", "mass": 21959.0, "length": 197, "protein_name": "Calcipressin-2", "gene_name": "RCAN2", "organism": "Chicken", "refseq_name": "calcipressin-2 isoform X2", "refseq_ac": "XP_004935981", "gene_names_uniprotkb": "RCAN2", "gene_names_refseq": "RCAN2", "protein_names_uniprotkb": "Calcipressin-2; Regulator of calcineurin 2", "protein_names_refseq": "calcipressin-2 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:422057)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ08-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1Z1-1", "uniprot_id": "A0A8V0Y1Z1_CHICK", "mass": 15868.0, "length": 142, "protein_name": "Signal recognition particle 19 kDa protein", "gene_name": "SRP19", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SRP19", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal recognition particle 19 kDa protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:770061); (R-GGA-1799339)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0006614 SRP-dependent cotranslational protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1Z1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1Q3-1", "uniprot_id": "A0A8V0Y1Q3_CHICK", "mass": 27654.0, "length": 242, "protein_name": "Peroxisomal coenzyme A diphosphatase NUDT7", "gene_name": "NUDT7", "organism": "Chicken", "refseq_name": "peroxisomal coenzyme A diphosphatase NUDT7", "refseq_ac": "NP_001238995", "gene_names_uniprotkb": "NUDT7", "gene_names_refseq": "NUDT7", "protein_names_uniprotkb": "Peroxisomal coenzyme A diphosphatase NUDT7; 3.6.1.77; Nucleoside diphosphate-linked moiety X motif 7", "protein_names_refseq": "nudix (nucleoside diphosphate linked moiety X)-type motif 7; peroxisomal coenzyme A diphosphatase NUDT7", "tax_id": 9031, "disease": "", "pathway": " (gga:415800); (R-GGA-9033241)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000698.1, BX934832.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Sep 23, 2021 this sequence version replaced NP_001238995.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene.The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;1.14.13.39;4.1.3.4;4.1.2.63;3.6.1.9;3.6.1.68;3.6.1.76;2.3.1.137;4.1.1.9;3.6.1.77;5.3.3.21;2.3.1.42;3.1.2.2;3.1.2.27;3.1.2.1;3.1.2.11;3.1.2.3;3.1.2.5;2.3.2.27;3.4.24.56;1.3.1.38;3.4.21.-;1.1.1.42;1.5.3.13;1.11.1.6;1.1.3.15;2.6.1.51;2.6.1.44;1.1.1.35;4.2.1.17;5.3.3.8;2.3.1.176;2.3.1.16;2.3.1.155;2.3.1.7;1.5.3.1;1.5.3.7;2.5.1.18;1.3.1.124;5.1.99.4;3.6.1.-;3.6.1.17", "go_molecular_function": "GO:0046872 metal ion binding;GO:0010945 coenzyme A diphosphatase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0036114 medium-chain fatty-acyl-CoA catabolic process;GO:2001294 malonyl-CoA catabolic process;GO:0009132 nucleoside diphosphate metabolic process;GO:0015938 coenzyme A catabolic process;GO:0044580 butyryl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZZ4-1", "uniprot_id": "A0A8V0XZZ4_CHICK", "mass": 52896.0, "length": 476, "protein_name": "glutathione-disulfide reductase", "gene_name": "GSR", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GSR", "gene_names_refseq": "", "protein_names_uniprotkb": "glutathione-disulfide reductase; 1.8.1.7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:771783); (R-GGA-3299685); (R-GGA-499943); (R-GGA-5628897)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.1.7;1.8.1.9", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004362 glutathione-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045454 cell redox homeostasis;GO:0006749 glutathione metabolic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZZ4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYE0-1", "uniprot_id": "A0A8V0XYE0_CHICK", "mass": 65168.0, "length": 570, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "GALNT2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GALNT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6811436); (R-GGA-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;3.6.5.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0030145 manganese ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0051604 protein maturation;GO:0002639 positive regulation of immunoglobulin production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYE0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXH1-1", "uniprot_id": "A0A8V0XXH1_CHICK", "mass": 92570.0, "length": 826, "protein_name": "Ribosome biogenesis protein BOP1", "gene_name": "BOP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BOP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosome biogenesis protein BOP1; Block of proliferation 1 protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0005694 chromosome;GO:0070545 PeBoW complex", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0008283 cell population proliferation;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXH1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90694-1", "uniprot_id": "CDC42_CHICK", "mass": 21273.0, "length": 191, "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "organism": "Chicken", "refseq_name": "cell division control protein 42 homolog", "refseq_ac": "NP_990379", "gene_names_uniprotkb": "CDC42", "gene_names_refseq": "CDC42", "protein_names_uniprotkb": "Cell division control protein 42 homolog; 3.6.5.2; G25K GTP-binding protein", "protein_names_refseq": "G25K GTP-binding protein; cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa)", "tax_id": 9031, "disease": "", "pathway": " (gga:395917); (R-GGA-114604); (R-GGA-182971); (R-GGA-2029482); (R-GGA-389359); (R-GGA-3928662); (R-GGA-4420097); (R-GGA-525793); (R-GGA-5625970); (R-GGA-5626467); (R-GGA-5627123); (R-GGA-5663213); (R-GGA-5663220); (R-GGA-5687128); (R-GGA-8964616); (R-GGA-9013148); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013406); (R-GGA-9013408); (R-GGA-9013420); (R-GGA-9013423); (R-GGA-9013424); (R-GGA-983231); (R-GGA-9958810); (R-GGA-9958825)", "pathway_count": 26, "publication_count": 1, "publication_id_list": "9224952", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U40848.1, SRR12888524.149381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000329.1., [RefSeq]; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;2.7.11.24;3.6.5.5;2.7.11.1;2.7.10.2;7.6.2.2;7.6.2.3;2.7.10.1;2.3.2.26;2.3.2.27;3.6.5.-;3.1.3.16;3.6.5.3;3.1.4.4;3.6.4.12;1.3.1.70;3.6.1.5;2.7.11.13;3.4.19.12;2.7.11.21;3.6.4.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0034191 apolipoprotein A-I receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0006897 endocytosis;GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90694-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90623-1", "uniprot_id": "MYPT1_CHICK", "mass": 111606.0, "length": 1004, "protein_name": "Protein phosphatase 1 regulatory subunit 12A", "gene_name": "PPP1R12A", "organism": "Chicken", "refseq_name": "protein phosphatase 1 regulatory subunit 12A", "refseq_ac": "NP_990454", "gene_names_uniprotkb": "PPP1R12A; MBS; MYPT1", "gene_names_refseq": "MBSP; MBS; MYPT1; PPP1R12A", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 12A; 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase; Myosin phosphatase target subunit 1; Myosin phosphatase-targeting subunit 1; PP1M subunit M110; Protein phosphatase myosin-binding subunit", "protein_names_refseq": "130 kDa myosin-binding subunit of smooth muscle myosin phophatase; 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase; 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133); PP1M subunit M110; myosin phosphatase target subunit 1; myosin phosphatase-targeting subunit 1; protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase myosin-binding subunit; smooth muscle myosin phosphatase myosin-binding subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:396020); (R-GGA-2565942); (R-GGA-5627123)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10601309;11287000;11976330;12220642;15164081;15581619;16081075;16297917;18840611;7982954;7988720", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D37985.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Crystal structure at 2.7 A resolution of the complex between PP1 and a 34-kDa N-terminal domain of the myosin phosphatase targeting subunit MYPT1., [RefSeq, PubMed]; Phosphorylation of both Thr695 and Thr850 by Rho-kinase inhibited activity of the MYPT1 subunit M133. Rates of phosphorylation of the two sites were similar and efficacy of inhibition following phosphorylation was equivalent for each site., [RefSeq, PubMed]; Regulates myosin phosphatase activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q10727;Q90624", "ec_number_list": "", "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019901 protein kinase binding;GO:0071889 14-3-3 protein binding;GO:0019208 phosphatase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001725 stress fiber;GO:0030018 Z disc;GO:0031672 A band;GO:0072357 PTW/PP1 phosphatase complex", "go_biological_process": "GO:0007165 signal transduction;GO:0030155 regulation of cell adhesion;GO:0048812 neuron projection morphogenesis;GO:0000278 mitotic cell cycle;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q90623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90999-1", "uniprot_id": "TGFR2_CHICK", "mass": 63308.0, "length": 557, "protein_name": "TGF-beta receptor type-2", "gene_name": "TGFBR2", "organism": "Chicken", "refseq_name": "TGF-beta receptor type-2 precursor", "refseq_ac": "NP_990759", "gene_names_uniprotkb": "TGFBR2", "gene_names_refseq": "TGFBR2", "protein_names_uniprotkb": "TGF-beta receptor type-2; 2.7.11.30; TGF-beta receptor type II; TGF-beta type II receptor; TGFR-2; TbetaR-II; Transforming growth factor-beta receptor type II", "protein_names_refseq": "TGF-beta receptor type II; TGF-beta receptor type-2 precursor; TGF-beta receptor type-2; TGF-beta type II receptor; TGFR-2; TGFbeta type II receptor; tbetaR-II; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor-beta receptor type II; transforming growth factor-beta type II receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:396399); (R-GGA-2173788); (R-GGA-2173789); (R-GGA-2173791); (R-GGA-9839389)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "12589747;24166734;24286074;8167376", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L18784.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; MRNA expression of genes of the TGF beta family and endothelin 1 in lung samples from 4-week-old chickens with pulmonary hypertension, were determined., [RefSeq, PubMed]; TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures, [RefSeq, PubMed]; Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.30;2.3.2.26;2.3.2.27;2.7.11.13", "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity;GO:0005024 transforming growth factor beta receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0043235 receptor complex;GO:0045121 membrane raft", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007399 nervous system development;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90999-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JG64-1", "uniprot_id": "PDIA3_CHICK", "mass": 56182.0, "length": 505, "protein_name": "Protein disulfide-isomerase A3", "gene_name": "PDIA3", "organism": "Chicken", "refseq_name": "protein disulfide-isomerase A3 precursor", "refseq_ac": "NP_989441", "gene_names_uniprotkb": "PDIA3; ERP57; GRP58", "gene_names_refseq": "25D3-membrane-associated; 58kDa; ERp57; GRP58; PDIA3", "protein_names_uniprotkb": "Protein disulfide-isomerase A3; 5.3.4.1; ER protein 57; ERp57; Endoplasmic reticulum resident protein 57; Glucose-regulated thiol oxidoreductase 58 kDa protein", "protein_names_refseq": "1,25D3-MARRS protein; 1,25D3-membrane-associated, rapid-response steroid-binding protein; ER protein 57; endoplasmic reticulum resident protein 57; glucose regulated protein, 58kDa; glucose regulated thiol oxidoreductase protein; glucose-regulated thiol oxidoreductase 58 kDa protein; protein disulfide-isomerase A3 precursor; protein disulfide-isomerase A3", "tax_id": 9031, "disease": "", "pathway": " (gga:373899); (R-GGA-1236974); (R-GGA-901042); (R-GGA-983170)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "15123837;15225786;15862830", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000271.1, BX936044.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000246.1., [RefSeq]; 1,25D3-MARRS has a role in steroid stimulated calcium uptake [review] Review article, [RefSeq, PubMed]; Determination of link phosphate transport in the chick duodenum with the 1,25D(3)-MARRS protein and point to a previously uncharacterized role for this multifunctional protein class GeneRIF: 1,25D3-MARRS protein acts as an apparent membrane receptor for the steroid hormone 1,25-dihydroxyvitamin D3. Binding of ligand to 1,25D3-MARRS protein initiates signal transduction events leading to phosphate uptake and transport in intestine., [RefSeq, PubMed]; Identification and characterization of open coding region, signal peptides and translation product, [RefSeq, PubMed]; Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.4.1;3.6.4.10", "go_molecular_function": "GO:0042802 identical protein binding;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity;GO:0044183 protein folding chaperone;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0042470 melanosome", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress;GO:0002502 peptide antigen assembly with MHC class I protein complex", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JG64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DF58-1", "uniprot_id": "ILK_CHICK", "mass": 51518.0, "length": 452, "protein_name": "Scaffold protein ILK", "gene_name": "ILK", "organism": "Chicken", "refseq_name": "scaffold protein ILK", "refseq_ac": "NP_989525", "gene_names_uniprotkb": "ILK; ILK1; ILK2", "gene_names_refseq": "ILK-1; ILK-2; ILK1; ILK2; ILK; p59ILK", "protein_names_uniprotkb": "Scaffold protein ILK; ILK-1; ILK-2; Inactive integrin-linked kinase; p59ILK", "protein_names_refseq": "59 kDa serine/threonine-protein kinase; beta-integrin-linked kinase; inactive integrin-linked kinase; integrin-linked protein kinase; scaffold protein ILK", "tax_id": 9031, "disease": "", "pathway": " (gga:374018)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11278951;15592404;15735674;15817463;22521536;34359835", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF296130.1, HAEL01000441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000032.1., [RefSeq]; ILK regulates both integrin-associated rearrangements of actin filaments and cell migration and invasion at the integrin receptor-proximal region, [RefSeq, PubMed]; ILK with the PKCalpha phosphorylation sites mutated disrupts RGC axon pathfinding at the optic chiasm., [RefSeq, PubMed]; Integrin-Linked Kinase (ILK) Plays an Important Role in the Laminin-Dependent Development of Dorsal Root Ganglia during Chicken Embryogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0005178 integrin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072697 protein localization to cell cortex;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0051017 actin filament bundle assembly;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DF58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90972-1", "uniprot_id": "RNF13_CHICK", "mass": 42820.0, "length": 381, "protein_name": "E3 ubiquitin-protein ligase RNF13", "gene_name": "RNF13", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase RNF13 precursor", "refseq_ac": "NP_990686", "gene_names_uniprotkb": "RNF13; RZF", "gene_names_refseq": "RNF13; RZF", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF13; 2.3.2.27; C-RZF; RING finger protein 13", "protein_names_refseq": "C-RZF; E3 ubiquitin-protein ligase RNF13 precursor; E3 ubiquitin-protein ligase RNF13; RING zinc finger protein; RING-type E3 ubiquitin transferase RNF13", "tax_id": 9031, "disease": "", "pathway": " (gga:396303)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20015074;8610176", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01044517.1, X95455.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1., [RefSeq]; E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:20015074). Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity)., [UniProtKB, PubMed, UniProtKB]; Mutations disrupting the RING finger abolish the growth-suppressive activity of RNF13, indicating that its E3 ligase activity is required for the inhibition of cell proliferation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q533M4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90972-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YH18-1", "uniprot_id": "QKI_CHICK", "mass": 37570.0, "length": 340, "protein_name": "KH domain-containing RNA-binding protein QKI", "gene_name": "QKI", "organism": "Chicken", "refseq_name": "KH domain-containing RNA-binding protein QKI", "refseq_ac": "NP_989641", "gene_names_uniprotkb": "QKI", "gene_names_refseq": "QKI", "protein_names_uniprotkb": "KH domain-containing RNA-binding protein QKI; Protein quaking", "protein_names_refseq": "KH domain-containing RNA-binding protein QKI; RNA binding/signal transduction protein QkI-2; homolog of mouse quaking QKI (KH domain RNA binding protein); protein quaking; quaking homolog, KH domain RNA binding", "tax_id": 9031, "disease": "", "pathway": " (gga:374204)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9547512", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.300323.1, SRR13267655.172155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1. On Feb 15, 2008 this sequence version replaced NP_989641.1., [RefSeq]; RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (By similarity). Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (By similarity). Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) (By similarity). Promotes the formation of circular RNAs (circRNAs): acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation (By similarity). Acts as an important regulator of muscle development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9PST2;Q9YH19;Q9YH20", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0003730 mRNA 3'-UTR binding;GO:0160089 internal N(7)-methylguanine-containing RNA reader activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0017148 negative regulation of translation;GO:0045650 negative regulation of macrophage differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9YH18-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YH06-1", "uniprot_id": "HMGB1_CHICK", "mass": 24909.0, "length": 215, "protein_name": "High mobility group protein B1", "gene_name": "HMGB1", "organism": "Chicken", "refseq_name": "high mobility group protein B1", "refseq_ac": "NP_990233", "gene_names_uniprotkb": "HMGB1; HMG1; RCJMB04_15a21", "gene_names_refseq": "HMG-1; HMG1; HMGB1", "protein_names_uniprotkb": "High mobility group protein B1; HMG-1; High mobility group protein 1", "protein_names_refseq": "high mobility group 1 protein; high mobility group protein 1; high mobility group protein B1; high mobility group protein HMG1", "tax_id": 9031, "disease": "", "pathway": " (gga:395724); (R-GGA-140342); (R-GGA-3000471); (R-GGA-5620971); (R-GGA-5686938); (R-GGA-6798695)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10978508;15592404;15642098;18241198;19102706;9931456", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851648.1, Y17968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ851648.1., [RefSeq]; Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucleic acids. May promote inflammatory response to sterile and infectious signals and may be involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm may function as sensor and/or chaperone for immunogenic nucleic acids, and mediate autophagy. May act as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Specific regions of the acidic tail participate in intramolecular interactions with Lys2 of HMGB1 and in intermolecular interactions with Lys36 and Lys37 of histone H3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H9BNX0;Q9PUK9", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0000400 four-way junction DNA binding;GO:0000405 bubble DNA binding;GO:0044378 non-sequence-specific DNA binding, bending;GO:0097100 supercoiled DNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0005615 extracellular space", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0032392 DNA geometric change;GO:0002270 plasmacytoid dendritic cell activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9YH06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IA05-1", "uniprot_id": "FZD4_CHICK", "mass": 58766.0, "length": 525, "protein_name": "Frizzled-4", "gene_name": "FZD4", "organism": "Chicken", "refseq_name": "frizzled-4 precursor", "refseq_ac": "NP_989430", "gene_names_uniprotkb": "FZD4; FZ4", "gene_names_refseq": "FZ-4; FZ4; FZD4", "protein_names_uniprotkb": "Frizzled-4; Fz-4; cFz-4", "protein_names_refseq": "cFz-4; frizzled family receptor 4; frizzled homolog 4; frizzled-4 precursor; frizzled-4", "tax_id": 9031, "disease": "", "pathway": " (gga:373887); (R-GGA-4086398); (R-GGA-4608870); (R-GGA-4641263); (R-GGA-5099900)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10512196;10781956;21856951", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF224316.1, SRR13267652.216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000027.1., [RefSeq]; Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase (By similarity). Both pathways seem to involve interactions with G proteins (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9PTW2", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0001540 amyloid-beta binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0001570 vasculogenesis;GO:0030335 positive regulation of cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9IA05-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90845-1", "uniprot_id": "GBRA6_CHICK", "mass": 51718.0, "length": 465, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-6", "gene_name": "GABRA6", "organism": "Chicken", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-6 precursor", "refseq_ac": "NP_990389", "gene_names_uniprotkb": "GABRA6", "gene_names_refseq": "GABRA6", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-6; GABA(A) receptor subunit alpha-6; GABAAR subunit alpha-6", "protein_names_refseq": "GABA(A) receptor subunit alpha-6; GABA-A receptor a6 subunit; GABAAR subunit alpha-6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid receptor subunit alpha-6 precursor; gamma-aminobutyric acid receptor subunit alpha-6", "tax_id": 9031, "disease": "", "pathway": " (gga:395931); (R-GGA-977443)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8780005", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X94343.1, SRR12888496.52845.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1., [RefSeq]; Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6", "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0005254 chloride channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90845-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90669-1", "uniprot_id": "AVR2A_CHICK", "mass": 58092.0, "length": 513, "protein_name": "Activin receptor type-2A", "gene_name": "ACVR2A", "organism": "Chicken", "refseq_name": "activin receptor type-2A precursor", "refseq_ac": "NP_990698", "gene_names_uniprotkb": "ACVR2A", "gene_names_refseq": "ACVR2A", "protein_names_uniprotkb": "Activin receptor type-2A; 2.7.11.30; ACTR-IIA; ACTRIIA; Activin receptor type IIA", "protein_names_refseq": "ACTR-IIA; ACTRIIA; activin A receptor, type IIA; activin receptor IIA; activin receptor type 2A; activin receptor type IIA; activin receptor type-2A precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396324); (R-GGA-1502540); (R-GGA-201451); (R-GGA-9839406)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11291100;1318847;16039645;16135664;16461550;27635666;31127166;7589799", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U31222.1, SRR13267659.257754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000236.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Between broiler and layer lines, there were no significant changes in expression of the ACVR2A gene during embryonic stages but it varied significantly during the post-hatch period. The shRNA showed silencing of the ACVR2A gene under an in vitro cell culture system., [RefSeq, PubMed]; Chicken ACVR2A & ACVR2B cause formation of ectopic axial structures in amphibian embryos. Authors conclude that ACVR2 receptors affect axial patterning (GO:0009798 axis specification), [RefSeq, PubMed]; Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Publication Status: Online-Only, [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q90745", "ec_number_list": "2.7.11.30;2.3.2.26", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0048185 activin binding;GO:0017002 activin receptor activity;GO:0015026 coreceptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048179 activin receptor complex;GO:0009986 cell surface", "go_biological_process": "GO:0009798 axis specification;GO:0008283 cell population proliferation;GO:0071363 cellular response to growth factor stimulus;GO:0032924 activin receptor signaling pathway;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q90669-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IA95-1", "uniprot_id": "SFRP3_CHICK", "mass": 35004.0, "length": 315, "protein_name": "Secreted frizzled-related protein 3", "gene_name": "FRZB", "organism": "Chicken", "refseq_name": "secreted frizzled-related protein 3 precursor", "refseq_ac": "NP_990103", "gene_names_uniprotkb": "FRZB; SFRP3", "gene_names_refseq": "FRZB; Frzb-1", "protein_names_uniprotkb": "Secreted frizzled-related protein 3; Frizzled-related protein 1; FrzB-1; sFRP-3", "protein_names_refseq": "frizzled-related protein 1; sFRP-3; secreted frizzled-related protein 3 precursor; secreted frizzled-related protein 3", "tax_id": 9031, "disease": "", "pathway": " (gga:395545)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10656762;12413904;15649459;16425220", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ017062.1, AF218057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000235.1., [RefSeq]; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Wnt-9a and Frzb regulate mesenchymal cell proliferation leading to proper AV canal cushion outgrowth and remodeling in the developing heart., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4U3E3", "ec_number_list": "", "go_molecular_function": "GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0048731 system development;GO:0008285 negative regulation of cell population proliferation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0014033 neural crest cell differentiation;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9IA95-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90ZF9-1", "uniprot_id": "CENPH_CHICK", "mass": 26800.0, "length": 235, "protein_name": "Centromere protein H", "gene_name": "CENPH", "organism": "Chicken", "refseq_name": "centromere protein H", "refseq_ac": "NP_989942", "gene_names_uniprotkb": "CENPH", "gene_names_refseq": "CENP-H; CENPH", "protein_names_uniprotkb": "Centromere protein H; CENP-H", "protein_names_refseq": "centromere protein H", "tax_id": 9031, "disease": "", "pathway": " (gga:395316); (R-GGA-141430); (R-GGA-141444); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-5663220); (R-GGA-606279); (R-GGA-9648025)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "11500386;15713649;16622420;19625449;30396998", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB055783.1, HAEL01004271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000089.1., [RefSeq]; CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1., [RefSeq, PubMed]; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex., [UniProtKB, PubMed]; The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres., [RefSeq, PubMed]; The functional region of chicken CENP-H necessary for centromere targeting and cell viability was identified., [RefSeq, PubMed]; The occurrence of centromere-heterochromatin associations depends on CENP-H, but not CENP-C., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043515 kinetochore binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90ZF9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92172-1", "uniprot_id": "TEF_CHICK", "mass": 34954.0, "length": 319, "protein_name": "Transcription factor VBP", "gene_name": "TEF", "organism": "Chicken", "refseq_name": "transcription factor VBP isoform 2", "refseq_ac": "NP_990713", "gene_names_uniprotkb": "TEF; VBP", "gene_names_refseq": "TEF; VBP", "protein_names_uniprotkb": "Transcription factor VBP; Thyrotroph embryonic factor homolog; Vitellogenin gene-binding protein", "protein_names_refseq": "thyrotroph embryonic factor homolog; thyrotrophic embryonic factor; transcription factor VBP isoform 2; transcription factor VBP; vitellogenin gene-binding protein, alpha/alpha isoform", "tax_id": 9031, "disease": "", "pathway": " (gga:396342)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1922023;7984425", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888486.299859.1, U09221.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Aug 30, 2004 this sequence version replaced XP_429304.1., [RefSeq]; Transcription factor that binds to and transactivates the vitellogenin II (VTG2) promoter. Binds to the palindromic sequence 5'-GTTTACATAAAC-3'., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q788X3;Q92057", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q92172-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W719-1", "uniprot_id": "HPRT_CHICK", "mass": 24609.0, "length": 218, "protein_name": "Hypoxanthine-guanine phosphoribosyltransferase", "gene_name": "HPRT1", "organism": "Chicken", "refseq_name": "hypoxanthine-guanine phosphoribosyltransferase", "refseq_ac": "NP_990179", "gene_names_uniprotkb": "HPRT1; HPRT", "gene_names_refseq": "HPRT1; HPRT", "protein_names_uniprotkb": "Hypoxanthine-guanine phosphoribosyltransferase; 2.4.2.8; HGPRTase; HGPRT", "protein_names_refseq": "HGPRTase; HGPRT; hypoxanthine guanine phosphoribosyl transferase; hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome); hypoxanthine-guanine phosphoribosyltransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:395653)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10198428", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01092994.1, SRR13267648.14931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1., [RefSeq]; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.2.8", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0002060 purine nucleobase binding;GO:0004422 hypoxanthine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0005829 cytosol", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0043103 hypoxanthine salvage;GO:0032264 IMP salvage;GO:0045964 positive regulation of dopamine metabolic process;GO:0006166 purine ribonucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W719-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PV94-1", "uniprot_id": "RSMB_CHICK", "mass": 24588.0, "length": 240, "protein_name": "Small nuclear ribonucleoprotein-associated protein B'", "gene_name": "SNRPB; SNRPN", "organism": "Chicken", "refseq_name": "small nuclear ribonucleoprotein-associated protein B'", "refseq_ac": "NP_989930", "gene_names_uniprotkb": "SNRPB; SNRPN", "gene_names_refseq": "SNRB'; SNRPB'; SNRPB; SNRPL; SNRPN", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein B'; Sm protein B'; Sm-B'; SmB'; snRNP-B'; snRPB'", "protein_names_refseq": "sm protein B'; sm-B'; smB'; small nuclear ribonucleoprotein B'; small nuclear ribonucleoprotein B; small nuclear ribonucleoprotein polypeptide B/B'; small nuclear ribonucleoprotein polypeptide-like; small nuclear ribonucleoprotein polypeptides B and B1; small nuclear ribonucleoprotein-associated protein B'; snRNP-B'", "tax_id": 9031, "disease": "", "pathway": " (gga:395298); (R-GGA-111367); (R-GGA-191859); (R-GGA-72163); (R-GGA-72165); (R-GGA-73856); (R-GGA-77588); (R-GGA-9770562)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "10556313", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01010428.1, HAEK01037998.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000328.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0070990 snRNP binding;GO:0070034 telomerase RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9PV94-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PW72-1", "uniprot_id": "PDLI4_CHICK", "mass": 35839.0, "length": 330, "protein_name": "PDZ and LIM domain protein 4", "gene_name": "PDLIM4", "organism": "Chicken", "refseq_name": "PDZ and LIM domain protein 4", "refseq_ac": "NP_990170", "gene_names_uniprotkb": "PDLIM4; RIL", "gene_names_refseq": "PDLIM4; RIL", "protein_names_uniprotkb": "PDZ and LIM domain protein 4; LIM protein RIL; Reversion-induced LIM protein", "protein_names_refseq": "LIM protein RIL; PDZ and LIM domain protein 4; reversion-induced LIM protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395643)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10918612;14729062", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF167295.1, HAEK01093245.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1., [RefSeq]; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0034777 recycling endosome lumen;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0030027 lamellipodium", "go_biological_process": "GO:0098976 excitatory chemical synaptic transmission;GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0060173 limb development;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9PW72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90674-1", "uniprot_id": "LSHR_CHICK", "mass": 81092.0, "length": 728, "protein_name": "Lutropin-choriogonadotropic hormone receptor", "gene_name": "LHCGR", "organism": "Chicken", "refseq_name": "lutropin-choriogonadotropic hormone receptor precursor", "refseq_ac": "NP_990267", "gene_names_uniprotkb": "LHCGR", "gene_names_refseq": "LHCGR; cLH-R", "protein_names_uniprotkb": "Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor; cLH-R", "protein_names_refseq": "LH receptor; LH/CG-R; LSH-R; luteinizing hormone receptor; lutropin-choriogonadotropic hormone receptor precursor; lutropin-choriogonadotropic hormone receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:395776)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15592404;19710202;22805579;24190488;26899318;8828833;9545511", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB009283.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992527 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000061.1., [RefSeq]; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Testosterone (10 or 100 ng/ml) increased STAR, P450scc, and LHCGR mRNAs, when added to 3 h cultures of F1 granulosa cells., [RefSeq, PubMed]; The associations between LHCGR polymorphisms and six reproductive traits, were estimated., [RefSeq, PubMed]; The expression profile of luteinizing hormone receptor in the reproductive tract of hens during forced molting is reported., [RefSeq, PubMed]; These results suggest that dietary supplementation with Se improved development of the seminiferous tubules at the cellular level and that SelW, GPx4, LHCGR, and ACE are involved., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1NGD6;Q76N37", "ec_number_list": "", "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0004964 luteinizing hormone receptor activity;GO:0035472 choriogonadotropin hormone receptor activity;GO:0038106 choriogonadotropin hormone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050890 cognition;GO:0008584 male gonad development;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q90674-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UW76-1", "uniprot_id": "TBX20_CHICK", "mass": 48687.0, "length": 440, "protein_name": "T-box transcription factor TBX20", "gene_name": "TBX20", "organism": "Chicken", "refseq_name": "T-box transcription factor TBX20", "refseq_ac": "NP_989475", "gene_names_uniprotkb": "TBX20", "gene_names_refseq": "TBX20", "protein_names_uniprotkb": "T-box transcription factor TBX20; T-box protein 20; cTbx20", "protein_names_refseq": "T-box protein 20; T-box transcription factor TBX20; cTbx20", "tax_id": 9031, "disease": "", "pathway": " (gga:373943)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11862462;14978031;17064679;28842809", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB070554.1, SRR13267655.126509.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1., [RefSeq]; Acts as a transcriptional regulator involved in heart developmental processes., [UniProtKB]; Tbx20 is cardiomyocyte lineage-specific marker gene and is expressed in proepicardial organ during chick cardiogenesis., [RefSeq, PubMed]; Tbx20 plays in repressing extracellular matrix remodeling and promoting cell proliferation in mesenchymal valve precursor populations in endocardial cushions during embryonic development., [RefSeq, PubMed]; To elucidate upstream signaling pathways that regulate Tbx5 and Tbx20 expression, recombinant bone morphogenetic protein-2 was added to cardiogenic explants from chick embryos. Tbx20, but not Tbx5, is induced by bone morphogenetic protein-2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0036302 atrioventricular canal development;GO:0060577 pulmonary vein morphogenesis;GO:0003175 tricuspid valve development;GO:0036306 embryonic heart tube elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8UW76-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I8T7-1", "uniprot_id": "BMAL1_CHICK", "mass": 69437.0, "length": 633, "protein_name": "Basic helix-loop-helix ARNT-like protein 1", "gene_name": "ARNTL; BMAL1", "organism": "Chicken", "refseq_name": "basic helix-loop-helix ARNT-like protein 1 isoform 1", "refseq_ac": "NP_001001463", "gene_names_uniprotkb": "ARNTL; BMAL1; ARNTL", "gene_names_refseq": "ARNTL; BMAL1", "protein_names_uniprotkb": "Basic helix-loop-helix ARNT-like protein 1; Aryl hydrocarbon receptor nuclear translocator-like protein 1; BMAL1b'; Brain and muscle ARNT-like 1; cBMAL1", "protein_names_refseq": "BMAL1b'; aryl hydrocarbon receptor nuclear translocator-like protein 1; bHLH-PAS transcription factor BMAL1; basic helix-loop-helix ARNT-like protein 1 isoform 1; basic helix-loop-helix ARNT-like protein 1; brain and muscle ARNT-like 1; cBMAL1; clock protein", "tax_id": 9031, "disease": "", "pathway": " (gga:374115)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10931848;11554928;15891043;16679554;20345751;22700438;27021352", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: ERR7563977.28154.1, ERR7563976.736.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Aug 30, 2004 this sequence version replaced XP_420961.1. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. [provided by RefSeq, Jan 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Expression of Bmal1 gene is detected in chicken pineal gland as a functional component of circadian rhythm., [RefSeq, PubMed]; NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages., [RefSeq, PubMed]; The phase of the rhythms of retinal cBmal1 and cAANAT mRNAs suggests a link between retinal cBmal1 and cAANAT expressions similar to the regulation of pineal cAANAT transcription., [RefSeq, PubMed]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively (By similarity). The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (By similarity). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3'. Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (By similarity). Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; VIP signaling may regulate BMAL1 expression and, thus, a daily rhythmicity within granulosa cells of preovulatory follicles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034751 aryl hydrocarbon receptor complex;GO:0005667 transcription regulator complex;GO:0016605 PML body", "go_biological_process": "GO:1901985 positive regulation of protein acetylation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051775 response to redox state;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9I8T7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90WR8-1", "uniprot_id": "SP3_CHICK", "mass": 80950.0, "length": 771, "protein_name": "Transcription factor Sp3", "gene_name": "SP3", "organism": "Chicken", "refseq_name": "transcription factor Sp3", "refseq_ac": "NP_989934", "gene_names_uniprotkb": "SP3", "gene_names_refseq": "SP3", "protein_names_uniprotkb": "Transcription factor Sp3", "protein_names_refseq": "transcription factor Sp3", "tax_id": 9031, "disease": "", "pathway": " (gga:395302); (R-GGA-3232118)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12821939;15849196;18557703;20153453", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ317961.1, SRR13267656.5013.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000236.1., [RefSeq]; Localized the GAS41 promoter close to the 3' end of the lysozyme gene and found that Sp1 and Sp3 bind to this promoter, [RefSeq, PubMed]; The SP3/SP1 ratio and Dlx5 are important regulators of the proximal Col10a1 promoter in hypertrophic cartilage, [RefSeq, PubMed]; These results demonstrate a dual role of SP3 in regulating the expression of the Grin1 gene, by repressing transcription in the 5'-UTR in undifferentiated cells as well as acting as a transcription factor, increasing Grin1 gene transcription in neurons., [RefSeq, PubMed]; Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90WR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DDT2-1", "uniprot_id": "BCAP_CHICK", "mass": 90156.0, "length": 800, "protein_name": "Phosphoinositide 3-kinase adapter protein 1", "gene_name": "PIK3AP1", "organism": "Chicken", "refseq_name": "phosphoinositide 3-kinase adapter protein 1", "refseq_ac": "NP_989681", "gene_names_uniprotkb": "PIK3AP1; BCAP", "gene_names_refseq": "BCAP; PIK3AP1", "protein_names_uniprotkb": "Phosphoinositide 3-kinase adapter protein 1; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1", "protein_names_refseq": "B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1; phosphoinositide 3-kinase adapter protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:374268); (R-GGA-1257604); (R-GGA-6811558); (R-GGA-983695)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11163197;11781242;12627965", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF293805.1, SRR13267654.214939.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000231.1., [RefSeq]; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DDL3", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0050727 regulation of inflammatory response;GO:0031929 TOR signaling;GO:0034134 toll-like receptor 2 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DDT2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90670-1", "uniprot_id": "AVR2B_CHICK", "mass": 57776.0, "length": 512, "protein_name": "Activin receptor type-2B", "gene_name": "ACVR2B", "organism": "Chicken", "refseq_name": "activin receptor type-2B precursor", "refseq_ac": "NP_989648", "gene_names_uniprotkb": "ACVR2B", "gene_names_refseq": "ACTR-IIB; ACVR2B; ActRIIB", "protein_names_uniprotkb": "Activin receptor type-2B; 2.7.11.30; ACTR-IIB; Activin receptor type IIB", "protein_names_refseq": "activin A receptor, type IIB; activin receptor type 2B; activin receptor type IIB; activin receptor type-2B precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:374213); (R-GGA-1502540); (R-GGA-201451)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11291100;16039645;16135664;16461550;25660516;31127166;31491670;7589799", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U31223.1, KX865073.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000035.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; And formed a sub cluster with in avian cluster. The current research provides insights about structural and functional aspects of the receptor and also aids in understanding the evolutionary history of ACTRIIB., [RefSeq, PubMed]; Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Publication Status: Online-Only, [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; This study demonstrated that the role of ACVR2B expression in ciliary ganglion neuronal development, investigating its function in neuronal differentiation and ontogenetic cell death., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.30;2.3.2.26", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0048185 activin binding;GO:0017002 activin receptor activity;GO:0019209 kinase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045178 basal part of cell;GO:0048179 activin receptor complex;GO:0005737 cytoplasm;GO:0043235 receptor complex", "go_biological_process": "GO:0009798 axis specification;GO:0008283 cell population proliferation;GO:0071363 cellular response to growth factor stimulus;GO:0032924 activin receptor signaling pathway;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q90670-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90611-1", "uniprot_id": "MMP2_CHICK", "mass": 74941.0, "length": 663, "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "organism": "Chicken", "refseq_name": "72 kDa type IV collagenase preproprotein", "refseq_ac": "NP_989751", "gene_names_uniprotkb": "MMP2", "gene_names_refseq": "MMP2", "protein_names_uniprotkb": "72 kDa type IV collagenase; 3.4.24.24; 72 kDa gelatinase; Gelatinase A; MMP-2; Matrix metalloproteinase-2", "protein_names_refseq": "72 kDa gelatinase; 72 kDa type IV collagenase preproprotein; 72 kDa type IV collagenase; MMP-2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2", "tax_id": 9031, "disease": "", "pathway": " (gga:386583); (R-GGA-1442490); (R-GGA-1474228); (R-GGA-1592389); (R-GGA-3928665); (R-GGA-9009391)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "15497141;1848240;24879699;26395636;27342592;28916318;8010954", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U07775.1, HAEK01041188.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Enhanced MMP-2, MMP-9 and TNF-alpha production in progressive phase correlated with sciatic nerve pathology in C. jejuni-induced Guillain-Barre syndrome in chicken model., [RefSeq, PubMed]; Matrix metalloproteinase 2 (MMP2) was identified in chicken bile. Chickens fed gelatin supplements showed higher levels of bile MMP expression. Bile MMP may be associated with digestion of collagens and other extracellular matrix proteins in avian diets., [RefSeq, PubMed]; Protein level of MMP-9 was diminished, while MMP-7 and TIMP-3 were elevated in the oviduct of growing birds. MMP-2 and TIMP-2 protein levels remained constant, with a slight increase in MMP-2 concentration just before reaching maturity., [RefSeq, PubMed]; Real-time polymerase chain reaction and western blot revealed different expression of MMP-2, -7, -9 and TIMP-2 and -3 on mRNA and protein levels, respectively, as well as activity of MMP-2 and -9 by activity assay in the oviduct parts., [RefSeq, PubMed]; TIMP-2 expression by cardiac neural crest cells initiates proMMP-2 activation important for their migration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.10.1;3.4.24.35;3.4.24.7;3.4.24.24", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0030017 sarcomere;GO:0005604 basement membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016477 cell migration;GO:0030198 extracellular matrix organization;GO:0001666 response to hypoxia;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q90611-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QFP8-1", "uniprot_id": "LIMK1_CHICK", "mass": 74445.0, "length": 662, "protein_name": "LIM domain kinase 1", "gene_name": "LIMK1", "organism": "Chicken", "refseq_name": "LIM domain kinase 1", "refseq_ac": "NP_989462", "gene_names_uniprotkb": "LIMK1", "gene_names_refseq": "LIMK1", "protein_names_uniprotkb": "LIM domain kinase 1; 2.7.11.1; LIMK-1; chLIMK1", "protein_names_refseq": "LIM domain kinase 1; LIMK-1; chLIMK1", "tax_id": 9031, "disease": "", "pathway": " (gga:373922); (R-GGA-2029482); (R-GGA-399954); (R-GGA-5627123)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12684437", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB073752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1., [RefSeq]; Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Required for motility of the axon growth cone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.10.2;2.7.11.22;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;3.6.5.2;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030054 cell junction;GO:0030426 growth cone", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0032233 positive regulation of actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8QFP8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91049-1", "uniprot_id": "OCLN_CHICK", "mass": 55864.0, "length": 504, "protein_name": "Occludin", "gene_name": "OCLN", "organism": "Chicken", "refseq_name": "occludin", "refseq_ac": "NP_990459", "gene_names_uniprotkb": "OCLN", "gene_names_refseq": "OCLN", "protein_names_uniprotkb": "Occludin", "protein_names_refseq": "occludin", "tax_id": 9031, "disease": "", "pathway": " (gga:396026)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19017651;22834550;28238709;8276896", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D21837.1, SRR13267649.10767.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D21837.1., [RefSeq]; A unique motif in the occludin sequence that is involved in the regulation of ZO-1 binding by reversible phosphorylation of specific Tyr residues., [RefSeq, PubMed]; Dietary Zn supplementation appeared to alleviate the loss of intestinal mucosal barrier function induced by S. Typhimurium challenge and the partial mechanism might be related to the increased expression of occludin and claudin-1 in broiler chickens., [RefSeq, PubMed]; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier., [UniProtKB, UniProtKB, UniProtKB]; The level of feed intake is related to or may directly regulate OCLN mRNA expression or may have an indirect effect through paracrine or autocrine factors in the ovary., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0008023 transcription elongation factor complex;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0070830 bicellular tight junction assembly;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0042795 snRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91049-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PTR5-1", "uniprot_id": "LIS1_CHICK", "mass": 46664.0, "length": 410, "protein_name": "Lissencephaly-1 homolog", "gene_name": "PAFAH1B1", "organism": "Chicken", "refseq_name": "lissencephaly-1 homolog", "refseq_ac": "NP_989655", "gene_names_uniprotkb": "PAFAH1B1; LIS1", "gene_names_refseq": "LIS1; PAFAH1B1", "protein_names_uniprotkb": "Lissencephaly-1 homolog", "protein_names_refseq": "LIS-1; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; chLIS1; lissencephaly-1 homolog; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); platelet-activating factor acetylhydrolase IB subunit alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:374224); (R-GGA-141430); (R-GGA-141444); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-2565942); (R-GGA-380259); (R-GGA-380270); (R-GGA-380284); (R-GGA-380320); (R-GGA-5620912); (R-GGA-5663220); (R-GGA-6811436); (R-GGA-8854518); (R-GGA-9648025)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "10603088;17522326", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF113946.1, HAEL01004968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1., [RefSeq]; LIS1/PAFAH1B1 plays a prominent role in microtubule advance during growth cone remodeling associated with axonogenesis., [RefSeq, PubMed]; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration., [UniProtKB, HAMAP]; Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0051219 phosphoprotein binding;GO:0051010 microtubule plus-end binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000235 astral microtubule;GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005938 cell cortex", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0008344 adult locomotory behavior;GO:0050885 neuromuscular process controlling balance;GO:0051301 cell division;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9PTR5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JG30-1", "uniprot_id": "ST1B1_CHICK", "mass": 34074.0, "length": 296, "protein_name": "Sulfotransferase 1B1", "gene_name": "SULT1B1", "organism": "Chicken", "refseq_name": "sulfotransferase 1B1", "refseq_ac": "NP_989876", "gene_names_uniprotkb": "SULT1B1; SULT1B", "gene_names_refseq": "ST1B1; SULT1B1; SULT1B", "protein_names_uniprotkb": "Sulfotransferase 1B1; 2.8.2.1; ST1B1; Sulfotransferase family cytosolic 1B member 1", "protein_names_refseq": "sulfotransferase 1B1; sulfotransferase 1B; sulfotransferase family cytosolic 1B member 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395227)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15234270", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000879.1, HAEK01125740.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1., [RefSeq]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.1", "go_molecular_function": "GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8JG30-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JH64-1", "uniprot_id": "BTK_CHICK", "mass": 75879.0, "length": 657, "protein_name": "Tyrosine-protein kinase BTK", "gene_name": "BTK", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BTK", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase BTK; 2.7.10.2; Bruton tyrosine kinase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "10339589;10811866;12912915;19290921;8691147;9751072", "class_list": "", "function": "Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:12912915, PubMed:8691147). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (By similarity). PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (By similarity). BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (By similarity). Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (By similarity). The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (By similarity). Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (By similarity). Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (By similarity). BTK also plays a critical role in transcription regulation (By similarity). Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (PubMed:10811866). BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (By similarity). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (By similarity). GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (By similarity). ARID3A and NFAT are other transcriptional target of BTK (By similarity). BTK is required for the formation of functional ARID3A DNA-binding complexes (By similarity). There is however no evidence that BTK itself binds directly to DNA (By similarity). BTK has a dual role in the regulation of apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8JH64-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8JIS3-1", "uniprot_id": "DER_CHICK", "mass": 26167.0, "length": 246, "protein_name": "D-erythrulose reductase", "gene_name": "DER", "organism": "Chicken", "refseq_name": "D-erythrulose reductase", "refseq_ac": "NP_989556", "gene_names_uniprotkb": "DER", "gene_names_refseq": "DCXR; DER; XR", "protein_names_uniprotkb": "D-erythrulose reductase; 1.1.1.10; 1.1.1.162; Probable L-xylulose reductase; XR", "protein_names_refseq": "D-erythrulose reductase; dicarbonyl/L-xylulose reductase; probable L-xylulose reductase", "tax_id": 9031, "disease": "", "pathway": " (gga:374066); (R-GGA-5661270)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12200544;7358641", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU128557.1, AB049356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000316.1. On Sep 23, 2021 this sequence version replaced NP_989556.1., [RefSeq]; Catalyzes the reduction of D-erythrulose to D-threitol with the concomitant oxidation of NAD(P)H to NAD(P)(+). NADH is less effective than NADPH. May also catalyze the reduction of L-xylulose., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.1.10;1.1.1.162", "go_molecular_function": "GO:0050038 L-xylulose reductase (NADPH) activity;GO:0004090 carbonyl reductase (NADPH) activity;GO:0047880 erythrulose reductase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005997 xylulose metabolic process;GO:0042732 D-xylose metabolic process;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JIS3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QG61-1", "uniprot_id": "CRY1_CHICK", "mass": 69672.0, "length": 621, "protein_name": "Cryptochrome-1", "gene_name": "CRY1", "organism": "Chicken", "refseq_name": "cryptochrome-1", "refseq_ac": "NP_989576", "gene_names_uniprotkb": "CRY1", "gene_names_refseq": "CRY1", "protein_names_uniprotkb": "Cryptochrome-1", "protein_names_refseq": "cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1; cryptochrome-1", "tax_id": 9031, "disease": "", "pathway": " (gga:374093)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11684328;15459395;17324421;23966619;30350127", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY034432.1, SRR13267659.301255.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]., [RefSeq]; Activated Cry1a is thus found at all those wavelengths at which birds can orient using their magnetic inclination compass, supporting the role of Cry1a as receptor molecule. Publication Status: Online-Only, [RefSeq, PubMed]; Cry1a was present under 565 nm green light of medium and high intensity, and hardly any under high intensity 502 nm turquoise, whereas we found activated Cry1a at all three tested intensities of 373 nm UV and 424 nm blue light. Activated Cry1a also was found when 590 nm yellow light was added to low-intensity light of the four colors; yet these light combinations result in impaired magnetic orientation., [RefSeq, PubMed]; Data characterize a non-opsin photoreception mechanism in the chick iris and suggest a conserved photoreceptive role for cryptochromes in vertebrates, [RefSeq, PubMed]; Environmental illumination activates a complex regulatory cascade that includes both up- and down-regulation of the Cry1 gene which inverses the 24h pattern of Cry1 mRNA expression within one period, [RefSeq, PubMed]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus (By similarity). Interacts with CLOCK-BMAL1 independently of PER proteins and is found at CLOCK-BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-BMAL1 in a poised and repressed state until the proper time for transcriptional activation (By similarity). Represses CLOCK-BMAL1-mediated transcriptional activation (PubMed:11684328)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0071949 FAD binding;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097381 photoreceptor disc membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0007623 circadian rhythm;GO:0031398 positive regulation of protein ubiquitination;GO:0045721 negative regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8QG61-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QGQ6-1", "uniprot_id": "CLOCK_CHICK", "mass": 98659.0, "length": 875, "protein_name": "Circadian locomoter output cycles protein kaput", "gene_name": "CLOCK", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CLOCK", "gene_names_refseq": "", "protein_names_uniprotkb": "Circadian locomoter output cycles protein kaput", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:373991)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10407173;10931848;11554928;20345751", "class_list": "", "function": "Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CLOCK regulates the circadian expression of AANAT in the retinal photoreceptor cells. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence (By similarity). CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9W6Q2;Q9W7C3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051775 response to redox state;GO:0006974 DNA damage response;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8QGQ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QGX4-1", "uniprot_id": "PRKDC_CHICK", "mass": 472657.0, "length": 4134, "protein_name": "DNA-dependent protein kinase catalytic subunit", "gene_name": "PRKDC", "organism": "Chicken", "refseq_name": "DNA-dependent protein kinase catalytic subunit", "refseq_ac": "NP_989989", "gene_names_uniprotkb": "PRKDC; XRCC7", "gene_names_refseq": "DNA-PKCS; PRKDC; dnapkcs", "protein_names_uniprotkb": "DNA-dependent protein kinase catalytic subunit; 2.7.11.1; DNA-PK catalytic subunit; DNA-PKcs", "protein_names_refseq": "DNA-PK catalytic subunit; DNA-dependent protein kinase catalytic subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:395376); (R-GGA-351433); (R-GGA-353423)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10757784;11003390;11839092;12422221;12509254;14561766;15059890;15800615;17123873;17515904;18046455;18674614;22529269;9008167;9736627", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB016240.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000043.1. On Sep 23, 2021 this sequence version replaced NP_989989.3., [RefSeq]; KU70 and DNA-PKcs unexpectedly function together during the induction of apoptosis., [RefSeq, PubMed]; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. Acts as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (By similarity). Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P79791;Q9DEI2", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;4.2.99.18;5.6.2.4;6.5.1.1;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004677 DNA-dependent protein kinase activity;GO:0106310 protein serine kinase activity;GO:0035979 histone H2AXS139 kinase activity", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000723 telomere maintenance;GO:0042254 ribosome biogenesis;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8QGX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8QHL3-1", "uniprot_id": "VGFR1_CHICK", "mass": 149426.0, "length": 1327, "protein_name": "Vascular endothelial growth factor receptor 1", "gene_name": "FLT1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FLT1; VEGFR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 1; 2.7.10.1; VEGFR-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374100)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11855824", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the regulation of angiogenesis, cell survival, cell migration, macrophage function, and chemotaxis. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates PLCG1. Promotes phosphorylation of AKT1 and CBL (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q8QHL2", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0005021 vascular endothelial growth factor receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0006935 chemotaxis;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8QHL3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UUW7-1", "uniprot_id": "KHDR1_CHICK", "mass": 46504.0, "length": 433, "protein_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "gene_name": "KHDRBS1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KHDRBS1; SAM68", "gene_names_refseq": "", "protein_names_uniprotkb": "KH domain-containing, RNA-binding, signal transduction-associated protein 1; Sam68; Src-associated in mitosis 68 kDa protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374071)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12163178", "class_list": "", "function": "Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:1990782 protein tyrosine kinase binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0046831 regulation of RNA export from nucleus;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8UUW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UVD9-1", "uniprot_id": "FUBP2_CHICK", "mass": 80644.0, "length": 769, "protein_name": "Far upstream element-binding protein 2", "gene_name": "KHSRP", "organism": "Chicken", "refseq_name": "far upstream element-binding protein 2", "refseq_ac": "NP_989608", "gene_names_uniprotkb": "KHSRP; FUBP2; ZPB2", "gene_names_refseq": "KHSRP", "protein_names_uniprotkb": "Far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; Zipcode-binding protein 2", "protein_names_refseq": "FUSE-binding protein 2; KH-type splicing regulatory protein (FUSE binding protein 2); KSRP; far upstream element-binding protein 2; zipcode-binding protein 2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11781334", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF461020.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF461020.1., [RefSeq]; Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Binds to a 54-nucleotide localization signal (the 'zipcode') found in the 3'-UTR of beta-actin mRNA and may play a role in its localization., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0043488 regulation of mRNA stability;GO:0010586 miRNA metabolic process;GO:0071345 cellular response to cytokine stimulus;GO:0045019 negative regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8UVD9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q8UW59-1", "uniprot_id": "PARK7_CHICK", "mass": 19943.0, "length": 189, "protein_name": "Protein/nucleic acid deglycase DJ-1", "gene_name": "PARK7", "organism": "Chicken", "refseq_name": "protein/nucleic acid deglycase DJ-1", "refseq_ac": "NP_989916", "gene_names_uniprotkb": "PARK7", "gene_names_refseq": "DJ-1; PARK7", "protein_names_uniprotkb": "Protein/nucleic acid deglycase DJ-1; 3.1.2.-; 3.5.1.-; 3.5.1.124; DJ-1; Maillard deglycase; Parkinson disease protein 7 homolog; Parkinsonism-associated deglycase; Protein DJ-1", "protein_names_refseq": "Parkinson disease 7; maillard deglycase; parkinson disease protein 7 homolog; parkinsonism-associated deglycase; protein DJ-1; protein deglycase DJ-1; protein/nucleic acid deglycase DJ-1", "tax_id": 9031, "disease": "", "pathway": " (gga:395277)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15976810", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB076264.1, SRR12888552.89524.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992531, SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB076264.1., [RefSeq]; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease. It is involved in neuroprotective mechanisms as well as cell growth and transformation. Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.1.124;3.1.2.-;3.5.1.-", "go_molecular_function": "GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0008233 peptidase activity;GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0036524 protein deglycase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8UW59-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90582-1", "uniprot_id": "Q90582_CHICK", "mass": 35674.0, "length": 324, "protein_name": "CCAAT/enhancer-binding protein", "gene_name": "CEBPA", "organism": "Chicken", "refseq_name": "CCAAT/enhancer-binding protein alpha", "refseq_ac": "NP_001026630", "gene_names_uniprotkb": "CEBPA", "gene_names_refseq": "CEBPA; cC/EBP", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein", "protein_names_refseq": "CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:427549); (R-GGA-9616222)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "20398782;24100085;24418194;25037819;26156393", "class_list": "", "function": "CEBPA involved in lipid metabolism in Beijing-You chickens., [RefSeq, PubMed]; CEBPA promoter is methylated in adipose tissue and may regulate chicken early adipose development, [RefSeq, PubMed]; Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase., [RefSeq, PubMed]; The result showed C-EBP alpha was sufficient to trigger the adipogenic program in chicken embryo fibroblasts, as demonstrated by accumulation of cytoplasmic lipid droplets and expression of the adipocyte marker gene., [RefSeq, PubMed]; The results of overexpressing C/EBPalpha and HNF4alpha in cultured cells confirmed that both C/EBPalpha and HNF4alpha contribute significantly to sustaining a high level of CYP2D49 transcription., [RefSeq, PubMed]; VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Aug 8, 2005 this sequence version replaced XP_425121.1., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "R4GLL1", "ec_number_list": "", "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0043032 positive regulation of macrophage activation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90582-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90584-1", "uniprot_id": "COHA1_CHICK", "mass": 151204.0, "length": 1495, "protein_name": "Collagen alpha-1(XVII) chain", "gene_name": "COL17A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "COL17A1; BP180; BPAG2", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(XVII) chain; 180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396503)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;1705041", "class_list": "", "function": "May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane., [UniProtKB]; The 120 kDa linear IgA disease antigen homolog is an anchoring filament component involved in dermal-epidermal cohesion., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0030056 hemidesmosome", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90584-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90593-1", "uniprot_id": "BIP_CHICK", "mass": 72019.0, "length": 652, "protein_name": "Endoplasmic reticulum chaperone BiP", "gene_name": "HSPA5", "organism": "Chicken", "refseq_name": "endoplasmic reticulum chaperone BiP precursor", "refseq_ac": "NP_990822", "gene_names_uniprotkb": "HSPA5; GRP78", "gene_names_refseq": "GRP78; HSPA5; Hsc70", "protein_names_uniprotkb": "Endoplasmic reticulum chaperone BiP; 3.6.4.10; 78 kDa glucose-regulated protein; BiP; Binding-immunoglobulin protein; GRP-78; HSP70 family protein 5; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein", "protein_names_refseq": "78 kDa glucose-regulated protein; GRP-78; HSP70 family protein 5; biP; binding-immunoglobulin protein; endoplasmic reticulum chaperone BiP precursor; endoplasmic reticulum chaperone BiP; heat shock 70 kDa protein 5; heat shock protein 70 family protein 5; heat shock protein family A member 5; immunoglobulin heavy chain-binding protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396487); (R-GGA-983170); (R-GGA-9909505)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "25576194;26125812;26944959;27599847;2841586", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01008906.1, M27260.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06140852, SAMN06140853 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000308.1., [RefSeq]; BiP/GRP78 played critical roles and works upstream of JNK-Bim in response to the ARV S1133-mediated apoptosis process., [RefSeq, PubMed]; Data indicate that mRNA expression level of GRP78 gene increased gradually under heat stress then decreased after a certain time suggesting that GRP78 mRNA expression is time- and tissue-dependent. Publication Status: Online-Only, [RefSeq, PubMed]; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Also binds and inactivates EIF2AK3/PERK in unstressed cells (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (By similarity). May also play a role in apoptosis and cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Helps subgroup J avian leucosis virus enter cells Publication Status: Online-Only, [RefSeq, PubMed]; These findings have important implications for the maintenance of chicken fibroblast cells through the inhibition of apoptosis and may lead to the development of new treatments for avian disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-;5.3.4.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0036498 IRE1-mediated unfolded protein response;GO:0043066 negative regulation of apoptotic process;GO:0031398 positive regulation of protein ubiquitination;GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90593-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90597-1", "uniprot_id": "MX_CHICK", "mass": 79493.0, "length": 705, "protein_name": "Interferon-induced GTP-binding protein Mx", "gene_name": "MX", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MX", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein Mx; Interferon-inducible Mx protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395313)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7648434", "class_list": "", "function": "Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KKN7;Q0PMS3;Q0PMS4;Q0PMS5;Q0PMS6;Q8JFB6;Q8JIF6;Q8JIF7", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0051607 defense response to virus;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90597-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90617-1", "uniprot_id": "LAMP2_CHICK", "mass": 46715.0, "length": 425, "protein_name": "Lysosome-associated membrane glycoprotein 2", "gene_name": "LAMP2", "organism": "Chicken", "refseq_name": "lysosome-associated membrane glycoprotein 2 isoform 3 precursor", "refseq_ac": "NP_001001749", "gene_names_uniprotkb": "LAMP2", "gene_names_refseq": "LAMP2", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 2; LAMP-2; Lysosome-associated membrane protein 2", "protein_names_refseq": "lysosome-associated membrane glycoprotein 2 isoform 3 precursor; lysosome-associated membrane glycoprotein 2; lysosome-associated membrane glycoprotein LAMP-2; lysosome-associated membrane protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:414800)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7546292", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01075184.1, U10547.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1. On or before Nov 18, 2025 this sequence version replaced NP_001384687.1, NP_001001749.1., [RefSeq]; Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (By similarity). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 20, "predicted_n_glycosites": 20, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q90616;Q90618", "ec_number_list": "", "go_molecular_function": "GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0061684 chaperone-mediated autophagy;GO:0006605 protein targeting;GO:0009267 cellular response to starvation;GO:0007042 lysosomal lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90617-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90640-1", "uniprot_id": "KIF4_CHICK", "mass": 138924.0, "length": 1225, "protein_name": "Chromosome-associated kinesin KIF4", "gene_name": "KIF4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KIF4; KIF4A", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromosome-associated kinesin KIF4; Chromokinesin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395823)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7876303;8108415", "class_list": "", "function": "Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Required for mitotic chromosomal positioning and bipolar spindle stabilization., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q90608", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005875 microtubule associated complex;GO:0005694 chromosome", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0007052 mitotic spindle organization;GO:0051231 spindle elongation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90640-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90688-1", "uniprot_id": "MYPC3_CHICK", "mass": 142288.0, "length": 1272, "protein_name": "Myosin-binding protein C, cardiac-type", "gene_name": "MYBPC3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MYBPC3", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform; Cardiac MyBP-C", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8576942;9784245", "class_list": "", "function": "Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle A bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. May be involved in the early phase of myofibrillogenesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q90907", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008307 structural constituent of muscle;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0032982 myosin filament;GO:0031430 M band", "go_biological_process": "GO:0007155 cell adhesion;GO:0045214 sarcomere organization;GO:0086004 regulation of cardiac muscle cell contraction;GO:0055010 ventricular cardiac muscle tissue morphogenesis;GO:0032971 regulation of muscle filament sliding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90691-1", "uniprot_id": "HAND1_CHICK", "mass": 22679.0, "length": 202, "protein_name": "Heart- and neural crest derivatives-expressed protein 1", "gene_name": "HAND1", "organism": "Chicken", "refseq_name": "heart- and neural crest derivatives-expressed protein 1", "refseq_ac": "NP_990296", "gene_names_uniprotkb": "HAND1; EHAND", "gene_names_refseq": "HAND1; eHAND", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 1; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND", "protein_names_refseq": "extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; heart- and neural crest derivatives-expressed protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395812)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8533092", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U40041.1, SRR13267662.37806.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1., [RefSeq]; Transcription factor (By similarity). Plays an essential role in cardiac morphogenesis (PubMed:8533092)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0003218 cardiac left ventricle formation;GO:0003219 cardiac right ventricle formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90691-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90703-1", "uniprot_id": "NOS2_CHICK", "mass": 129649.0, "length": 1136, "protein_name": "Nitric oxide synthase, inducible", "gene_name": "NOS2", "organism": "Chicken", "refseq_name": "nitric oxide synthase, inducible", "refseq_ac": "NP_990292", "gene_names_uniprotkb": "NOS2", "gene_names_refseq": "INOS; NOS2A; NOS2", "protein_names_uniprotkb": "Nitric oxide synthase, inducible; 1.14.13.39; Inducible NO synthase; Inducible NOS; Macrophage NOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2; iNOS", "protein_names_refseq": "NOS type II; inducible NO synthase; inducible NOS; inducible nitric oxide synthase; macrophage NOS; nitric oxide synthase 2, inducible; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase, inducible; peptidyl-cysteine S-nitrosylase NOS2", "tax_id": 9031, "disease": "", "pathway": " (gga:395807)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15050530;15108309;19586893;21607608;25336270;8662618;8707887;9709401", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U46504.1, ERR2365565.150611.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On Oct 27, 2021 this sequence version replaced NP_990292.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; CAT-1 isoform plays a role in L-Arg uptake, and L-Arg-mediated elevation of NO via iNOS promotes the growth of chick intestinal epithelial cells., [RefSeq, PubMed]; Data concluded that the mutation of iNOS and hypoxic increase of its expression were important base for adaptability to hypoxia in Tibetan chicken., [RefSeq, PubMed]; INOS gene polymorphism analyzed by PCR-RFLP method revealed difference in allele frequency. Kadaknath breed males had higher allele B frequency (0.81) than Aseel breed males (0.56)., [RefSeq, PubMed]; In the embryonic cardiovascular system, KLF-2 is expressed in regions of highest shear stress, and ET-1 and NOS-3 expression is related to shear stress, [RefSeq, PubMed]; Palmitate causes an increase in cellular eNOS and iNOS with the resultant NO production serving to protect cardiomyocytes from palmitate-induced cell death., [RefSeq, PubMed]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO may serve as both a paracrine and autocrine signal for modulating osteoclast bone resorption. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90677;Q90934", "ec_number_list": "1.14.13.39", "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide;GO:0032755 positive regulation of interleukin-6 production;GO:0045776 negative regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q90703-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90722-1", "uniprot_id": "FGF8_CHICK", "mass": 24807.0, "length": 214, "protein_name": "Fibroblast growth factor 8", "gene_name": "FGF8", "organism": "Chicken", "refseq_name": "fibroblast growth factor 8 precursor", "refseq_ac": "NP_001012785", "gene_names_uniprotkb": "FGF8", "gene_names_refseq": "FGF-8; FGF8", "protein_names_uniprotkb": "Fibroblast growth factor 8; FGF-8; HBGF-8; Heparin-binding growth factor 8", "protein_names_refseq": "HBGF-8; fibroblast growth factor 8 (androgen-induced); fibroblast growth factor 8 precursor; heparin-binding growth factor 8", "tax_id": 9031, "disease": "", "pathway": " (gga:396313)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11290326;22898776;23201021;26130757;28648799;8674413", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U55189.1, FJ882410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000232.1. On Sep 23, 2021 this sequence version replaced NP_001012785.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A precise and dynamic expression pattern of fibroblast growth factor 8 (Fgf8) was found in the high acuity area anlage, which was regulated by enzymes that degrade retinoic acid (RA)., [RefSeq, PubMed]; Also enhances FGF8 activity while inhibiting BMP5 and WNT3a signaling, [RefSeq, PubMed]; FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation., [RefSeq, PubMed]; FGF8 regulates embryonic limb development via WNT/b-catenin signaling, [RefSeq, PubMed]; Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules, [RefSeq, PubMed]; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q90722-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90733-1", "uniprot_id": "COT2_CHICK", "mass": 45427.0, "length": 410, "protein_name": "COUP transcription factor 2", "gene_name": "NR2F2", "organism": "Chicken", "refseq_name": "COUP transcription factor 2 isoform 1", "refseq_ac": "NP_989752", "gene_names_uniprotkb": "NR2F2; TFCOUP2", "gene_names_refseq": "COUP-TFII; NR2F2; TFCOUP2", "protein_names_uniprotkb": "COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; Nuclear receptor subfamily 2 group F member 2", "protein_names_refseq": "COUP transcription factor 2 isoform 1; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2", "tax_id": 9031, "disease": "", "pathway": " (gga:386585); (R-GGA-9940951)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "28859090;8119130", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U00697.1, SRR13267660.23982.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000245.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; In this study, we have shown that ENG inhibition and at the same time up-regulation of COUP-TFII expression promotes intussusceptive angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro) (By similarity). May be involved in motor neuron development., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90733-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90738-1", "uniprot_id": "AFAP1_CHICK", "mass": 81160.0, "length": 729, "protein_name": "Actin filament-associated protein 1", "gene_name": "AFAP1", "organism": "Chicken", "refseq_name": "actin filament-associated protein 1 isoform a", "refseq_ac": "NP_989536", "gene_names_uniprotkb": "AFAP1", "gene_names_refseq": "AFAP1; AFAP", "protein_names_uniprotkb": "Actin filament-associated protein 1; 110 kDa actin filament-associated protein; AFAP-110; Neural actin filament protein; pp110", "protein_names_refseq": "110 kDa actin filament-associated protein; AFAP-110; actin filament-associated protein 1 isoform a; neural actin filament protein; pp110", "tax_id": 9031, "disease": "", "pathway": " (gga:374034)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10666339;12134071;21236256;21984596;2476666;7876134;8247004;9350057;9619827;9655255", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Sep 29, 2021 this sequence version replaced NP_989536.1. Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a), also known as AFAP-120., [RefSeq]; AFAP-120, a variant form of the Src SH2/SH3-binding partner AFAP-110, is detected in brain and contains a novel internal sequence which binds to a 67-kDa protein., [RefSeq, PubMed]; Data indicate that in addition to its role in the regulation of cytoskeletal structures, AFAP may also be involved in c-Src mediated SRE/AP-1 transactivation., [RefSeq, PubMed]; Functions as an adapter molecule that links other proteins to the actin cytoskeleton. May function in facilitating interactions between SRC and actin filaments. May modulate changes in actin filament integrity and induce lamellipodia formation. Can cross-link actin filaments into both network and bundle structures., [UniProtKB]; Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate, [RefSeq, PubMed]; Results indicate that the association of AFAP with F-actin through actin-binding domain is crucial for AFAP to regulate cytoskeletal structures, [RefSeq, PubMed]; The integrity of the SH3 binding motif of AFAP-110 is required to facilitate tyrosine phosphorylation by, and stable complex formation with, Src, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90917", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0001725 stress fiber", "go_biological_process": "GO:0018108 peptidyl-tyrosine phosphorylation;GO:0009966 regulation of signal transduction;GO:0018109 peptidyl-arginine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q90738-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90744-1", "uniprot_id": "NAGAB_CHICK", "mass": 45615.0, "length": 405, "protein_name": "Alpha-N-acetylgalactosaminidase", "gene_name": "NAGA", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NAGA", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminidase; 3.2.1.49; Alpha-galactosidase B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12005440;8241271", "class_list": "", "function": "Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.-;3.2.1.49", "go_molecular_function": "GO:0004557 alpha-galactosidase activity;GO:0008456 alpha-N-acetylgalactosaminidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0019377 glycolipid catabolic process;GO:0009311 oligosaccharide metabolic process;GO:0016139 glycoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90752-1", "uniprot_id": "BMP4_CHICK", "mass": 46057.0, "length": 405, "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BMP4; BMP-4", "gene_names_refseq": "", "protein_names_uniprotkb": "Bone morphogenetic protein 4; BMP-4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "15363410;16943268;8119128;9927590", "class_list": "", "function": "Negatively regulates the structure and function of the limb apical ectodermal ridge., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0003007 heart morphogenesis;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90752-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90763-1", "uniprot_id": "CADH7_CHICK", "mass": 87172.0, "length": 785, "protein_name": "Cadherin-7", "gene_name": "CDH7", "organism": "Chicken", "refseq_name": "cadherin-7 precursor", "refseq_ac": "NP_989518", "gene_names_uniprotkb": "CDH7", "gene_names_refseq": "CDH7; cadherin-7", "protein_names_uniprotkb": "Cadherin-7", "protein_names_refseq": "cadherin 7, type 2; cadherin-7 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:374007)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15312902;16253998;26287727;29263249;30461190;36128560;7540531", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D42150.1, SRR13267655.86443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992528, SAMEA103992533 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000042.1. On Sep 23, 2021 this sequence version replaced NP_989518.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cadherin-7 is required for proper neural crest cell-placodal neuron interactions during trigeminal ganglion assembly., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]; Cdh7 functions as a receptor for Shh and enhances Shh signaling during neural tube patterning., [RefSeq, PubMed]; Expression of cadherin-7 at the synaptic level on the somata and the proximal neurites of identified neuron populations has been traced selectively in the developing chicken visual system., [RefSeq, PubMed]; Neural crest cell-placodal neuron interactions are mediated by Cadherin-7 and N-cadherin during early chick trigeminal ganglion assembly. Publication Status: Online-Only, [RefSeq, PubMed]; The endogenous expression of cadherin-7 in developing spinal cord is repressed through overexpression of Pax3 and Pax7., [RefSeq, PubMed]; The extracellular domain exerts by far the dominant effect on cell adhesivity, that of E-cadherin conferring high adhesivity, and that of cadherin-7 conferring low adhesivity, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q90763-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90788-1", "uniprot_id": "NKX25_CHICK", "mass": 33073.0, "length": 294, "protein_name": "Homeobox protein Nkx-2.5", "gene_name": "NKX-2.5", "organism": "Chicken", "refseq_name": "homeobox protein Nkx-2.5", "refseq_ac": "NP_990495", "gene_names_uniprotkb": "NKX-2.5; NKX2E", "gene_names_refseq": "CNKX-2.5; NKX-2.5; NKX2-5; NKX2E", "protein_names_uniprotkb": "Homeobox protein Nkx-2.5; Homeobox protein NK-2 homolog E; cNKx-2.5", "protein_names_refseq": "NK2 transcription factor related, locus 5; homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5", "tax_id": 9031, "disease": "", "pathway": " (gga:396073)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15329343;16245335;23165293;25752780;8575320", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X91838.1, SRR13267653.17320.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1., [RefSeq]; Characterized the cis-regulatory elements of the tinman homolog Nkx2.5, [RefSeq, PubMed]; Data indicate that myocardial markers ISL1, TNNI2 and NKX2-5 and HCN4 were studied in sequential stages of chick embryo development., [RefSeq, PubMed]; Nkx2.5 autoregulation is evolutionarily conserved in the second heart field, [RefSeq, PubMed]; Overexpression of Nkx2-5 causes inhibition of slow tonic myosin heavy chain protein, a late Purkinje fiber marker, but does not affect Cx40 levels, [RefSeq, PubMed]; Transcription factor required for the development of the heart and the spleen. Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0003285 septum secundum development;GO:0051891 positive regulation of cardioblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90788-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90830-1", "uniprot_id": "CRTAP_CHICK", "mass": 31494.0, "length": 271, "protein_name": "Cartilage-associated protein", "gene_name": "CRTAP", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CRTAP; CASP", "gene_names_refseq": "", "protein_names_uniprotkb": "Cartilage-associated protein; Dualin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395992)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9217321", "class_list": "", "function": "Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0006457 protein folding;GO:1904027 negative regulation of collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90830-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90844-1", "uniprot_id": "FST_CHICK", "mass": 38193.0, "length": 343, "protein_name": "Follistatin", "gene_name": "FST", "organism": "Chicken", "refseq_name": "follistatin precursor", "refseq_ac": "NP_990531", "gene_names_uniprotkb": "FST", "gene_names_refseq": "FST", "protein_names_uniprotkb": "Follistatin; Activin-binding protein; FS", "protein_names_refseq": "FS; activin-binding protein; follistatin precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396119)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17549728;33214222;7554497;7576634;8625798", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X87609.1, SRR12888548.50797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000089.1., [RefSeq]; Binds directly to activin and functions as an activin antagonist. Inhibits activin A signaling in the iris and regulates somatostatin phenotype in ciliary ganglion neurons. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)., [UniProtKB]; Suggest role for Follistatin in cardiac valvulogenesis in chick embryo., [RefSeq, PubMed]; The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q90680;Q9PS97", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0048185 activin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:1902870 negative regulation of amacrine cell differentiation;GO:0046670 positive regulation of retinal cell programmed cell death;GO:0010977 negative regulation of neuron projection development;GO:0032926 negative regulation of activin receptor signaling pathway;GO:1902864 negative regulation of embryonic camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90844-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90891-1", "uniprot_id": "MP2K2_CHICK", "mass": 44078.0, "length": 398, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 2", "gene_name": "MAP2K2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MAP2K2; MEK2; MKK2; PRKMK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 2; 2.7.12.2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396349); (R-GGA-451478)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9398267", "class_list": "", "function": "Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.10.2;2.7.10.1;2.7.11.22;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.10.4;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0005770 late endosome", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0000165 MAPK cascade;GO:0032872 regulation of stress-activated MAPK cascade;GO:0090170 regulation of Golgi inheritance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90891-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90953-1", "uniprot_id": "CSPG2_CHICK", "mass": 388083.0, "length": 3562, "protein_name": "Versican core protein", "gene_name": "VCAN", "organism": "Chicken", "refseq_name": "versican core protein precursor", "refseq_ac": "NP_990118", "gene_names_uniprotkb": "VCAN; CSPG2", "gene_names_refseq": "PG-M; VCAN", "protein_names_uniprotkb": "Versican core protein; Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; Large fibroblast proteoglycan; PG-M", "protein_names_refseq": "chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan core protein 2; large fibroblast proteoglycan; proteoglycan; versican core protein precursor; versican core protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395565)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17219410;18390636;21471361;22190409;8314802", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D13542.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D13542.1. On Jan 18, 2005 this sequence version replaced XP_429249.1., [RefSeq]; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid., [UniProtKB]; The ability of versican in regulating gap junction implied a potential role of versican in coordinating functions., [RefSeq, PubMed]; This newly clarified fibrillin-versican-hyaluronan (FiVerHy) complex and its cleavage products may be indispensable for the physiological properties important to the ciliary body and vitreous., [RefSeq, PubMed]; Versican V0 and V1 direct the growth of peripheral axons in the developing chick hindlimb, [RefSeq, PubMed]; Versican functions interactively with other matrix/cell surface molecules to facilitate establishment or maintenance of early joint interzone structure., [RefSeq, PubMed]", "predicted_glycosites": 31, "predicted_n_glycosites": 24, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 31, "binding_glycan_count": 0, "secondary_ac_list": "Q90945", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0005615 extracellular space;GO:0045202 synapse;GO:0001750 photoreceptor outer segment;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90953-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90955-1", "uniprot_id": "TEBP_CHICK", "mass": 16869.0, "length": 146, "protein_name": "Prostaglandin E synthase 3", "gene_name": "PTGES3", "organism": "Chicken", "refseq_name": "prostaglandin E synthase 3", "refseq_ac": "NP_001263235", "gene_names_uniprotkb": "PTGES3; TEBP", "gene_names_refseq": "CPGES; PTGES3; TEBP", "protein_names_uniprotkb": "Prostaglandin E synthase 3; 5.3.99.3; Cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23; cPGES", "protein_names_refseq": "cytosolic prostaglandin E2 synthase; hsp90 co-chaperone; progesterone receptor complex p23; prostaglandin E synthase 3; telomerase-binding protein p23", "tax_id": 9031, "disease": "", "pathway": " (gga:100859133)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8114727", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267657.16099.1, SRR12888490.252480.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000490.1. On Jan 30, 2013 this sequence version replaced XP_003643174.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Molecular chaperone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.3.99.3", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0033142 nuclear progesterone receptor binding;GO:0051879 Hsp90 protein binding;GO:0050220 prostaglandin-E synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:0001516 prostaglandin biosynthetic process;GO:0007004 telomere maintenance via telomerase;GO:1905323 telomerase holoenzyme complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90955-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90964-1", "uniprot_id": "FOXG1_CHICK", "mass": 48857.0, "length": 451, "protein_name": "Forkhead box protein G1", "gene_name": "FOXG1", "organism": "Chicken", "refseq_name": "forkhead box protein G1", "refseq_ac": "NP_990524", "gene_names_uniprotkb": "FOXG1; FKHL1; FOXG1B; QIN", "gene_names_refseq": "CBF-1; FKHL1; FOXG1B; FOXG1; Qin", "protein_names_uniprotkb": "Forkhead box protein G1; BF-1; BF1; Brain factor 1; CEQ 3-1; Forkhead-related protein FKHL1; FoxG1; N-62-5; Proto-oncogene C-QIN; cBF-1", "protein_names_refseq": "BF-1; BF1; CEQ 3-1; N-62-5; brain factor-1; forkhead box protein G1; forkhead-related protein FKHL1; proto-oncogene C-QIN", "tax_id": 9031, "disease": "", "pathway": " (gga:396110); (R-GGA-9617828)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "24917504;29774577;7831308;8757134", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: U47275.1, L36814.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U47275.1. On Aug 30, 2004 this sequence version replaced XP_429289.1., [RefSeq]; FOXG1 is the main candidate gene for hypoxia adaptability in Tibetan chicken, [RefSeq, PubMed]; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes., [UniProtKB]; Smad1 regulates Foxg1 expression in a pathway that affects fore- and midbrain patterning in the facial neural crest, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q90964-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90966-1", "uniprot_id": "RARA_CHICK", "mass": 50728.0, "length": 460, "protein_name": "Retinoic acid receptor alpha", "gene_name": "RARA", "organism": "Chicken", "refseq_name": "retinoic acid receptor alpha", "refseq_ac": "NP_989867", "gene_names_uniprotkb": "RARA; NR1B1", "gene_names_refseq": "NR1B1; RAR-ALPHA1; RARA", "protein_names_uniprotkb": "Retinoic acid receptor alpha; Nuclear receptor subfamily 1 group B member 1; RAR-alpha", "protein_names_refseq": "RAR-alpha; nuclear receptor subfamily 1 group B member 1; retinoic acid receptor alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:395213); (R-GGA-383280); (R-GGA-4090294); (R-GGA-5362517); (R-GGA-9616222)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "11493540;8619957", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: X73972.1 [ECO:0000331] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X73972.1. On Aug 30, 2004 this sequence version replaced XP_423040.1., [RefSeq]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning and appears to be required for skin development., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q90967", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90966-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90997-1", "uniprot_id": "TFR1_CHICK", "mass": 85659.0, "length": 776, "protein_name": "Transferrin receptor protein 1", "gene_name": "TFRC", "organism": "Chicken", "refseq_name": "transferrin receptor protein 1", "refseq_ac": "NP_990587", "gene_names_uniprotkb": "TFRC", "gene_names_refseq": "TFR2; TFRC", "protein_names_uniprotkb": "Transferrin receptor protein 1; TR; TfR1; TfR; Trfr", "protein_names_refseq": "TR; tfR1; tfR; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; trfr", "tax_id": 9031, "disease": "", "pathway": " (gga:396191)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18201558;1874449", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X55348.1, SRR13267649.207969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X55348.1 and JAENSK010000240.1. On Feb 19, 2015 this sequence version replaced NP_990587.1., [RefSeq]; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The simultaneous induction of multiple death signals from a stimulus via the TfR is of great interest to those researching cell death, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004998 transferrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0042470 melanosome", "go_biological_process": "GO:0031623 receptor internalization;GO:0006879 intracellular iron ion homeostasis;GO:0030890 positive regulation of B cell proliferation;GO:0042102 positive regulation of T cell proliferation;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90WU3-1", "uniprot_id": "DDX1_CHICK", "mass": 82484.0, "length": 740, "protein_name": "ATP-dependent RNA helicase DDX1", "gene_name": "DDX1", "organism": "Chicken", "refseq_name": "ATP-dependent RNA helicase DDX1", "refseq_ac": "NP_989894", "gene_names_uniprotkb": "DDX1", "gene_names_refseq": "DDX1", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX1; 3.6.4.13; DEAD box protein 1", "protein_names_refseq": "ATP-dependent RNA helicase DDX1; DEAD (Asp-Glu-Ala-Asp) box helicase 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD box protein DDX1", "tax_id": 9031, "disease": "", "pathway": " (gga:395249)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11955614", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY057383.1, HAEK01000388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000066.1. On Sep 23, 2021 this sequence version replaced NP_989894.1., [RefSeq]; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Acts as a positive regulator of transcription. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. Binds DNA and RNA. It is also an accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. Cooperates with ZBTB8OS (also known as archease) for the guanylylation of RTCB, a key intermediate step in activation of the tRNA ligase (By similarity). Binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006302 double-strand break repair;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90WU3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90X07-1", "uniprot_id": "PSN2_CHICK", "mass": 50500.0, "length": 451, "protein_name": "Presenilin-2", "gene_name": "PSEN2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PSEN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Presenilin-2; 3.4.23.-; PS-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11987239", "class_list": "", "function": "Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0070765 gamma-secretase complex", "go_biological_process": "GO:0035333 Notch receptor processing, ligand-dependent;GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0016485 protein processing;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90X07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90YI0-1", "uniprot_id": "IL6_CHICK", "mass": 26790.0, "length": 241, "protein_name": "Interleukin-6", "gene_name": "IL6", "organism": "Chicken", "refseq_name": "interleukin-6 precursor", "refseq_ac": "NP_989959", "gene_names_uniprotkb": "IL6", "gene_names_refseq": "CHIL-6; IL-6; IL6; interleukin-6", "protein_names_uniprotkb": "Interleukin-6; ChIL-6; IL-6", "protein_names_refseq": "interleukin 6 (interferon, beta 2); interleukin-6 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395337); (R-GGA-1059683); (R-GGA-381426); (R-GGA-8957275); (R-GGA-9958825)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "11101679;11488913;17495100;18612836;26276563;26872625;27852059;30365012", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ309540.1, HM179640.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440, SAMEA103992648 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000036.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Avian leukosis virus subgroup J induces VEGF expression via NF-kappaB/PI3K-dependent IL-6 production to promoter tumorigenesis., [RefSeq, PubMed]; Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells., [UniProtKB, UniProtKB]; IL-6 is involved in the progression of chicken arthritis induced by Staph. aureus, and it contributes to disease incidence and mortality, [RefSeq, PubMed]; RNA sequencing results revealed that the chicken IL6 was more downregulated in the intestinal mucosal layer of Necrotic enteritis induced chicken lines that are resistant and sensitive to avian leukosis and Marek's disease., [RefSeq, PubMed]; The expression of interleukin(IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha in amyoidosis arthropathy in chickens was studied., [RefSeq, PubMed]; The results of the current study indicate that thermal manipulation enhanced the heat tolerance through improving the protective immunological response to heat stress by enhancing the expression of interleukin-6 (IL-6) and modulating the expression of genes important in its induction pathways., [RefSeq, PubMed]; The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12beta, and IL-1beta were decreased in the experiment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005138 interleukin-6 receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:0070417 cellular response to cold;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q90YI0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90YK5-1", "uniprot_id": "HPSE_CHICK", "mass": 58386.0, "length": 523, "protein_name": "Heparanase", "gene_name": "HPSE", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HPSE; HPA", "gene_names_refseq": "", "protein_names_uniprotkb": "Heparanase; 3.2.1.166", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:373981)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11387326;12773484", "class_list": "", "function": "Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety (By similarity). Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030305 heparanase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0030200 heparan sulfate proteoglycan catabolic process;GO:0060055 angiogenesis involved in wound healing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90YK5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90Z16-1", "uniprot_id": "OPTN_CHICK", "mass": 64087.0, "length": 556, "protein_name": "Optineurin", "gene_name": "OPTN", "organism": "Chicken", "refseq_name": "optineurin isoform X1", "refseq_ac": "XP_046762287", "gene_names_uniprotkb": "OPTN", "gene_names_refseq": "OPTN", "protein_names_uniprotkb": "Optineurin; Ag9-C5; FIP-2", "protein_names_refseq": "optineurin isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:374079)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11777338;12169269", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052573.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Probably part of the TNF signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0006914 autophagy;GO:0090161 Golgi ribbon formation;GO:0034067 protein localization to Golgi apparatus;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90Z16-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90Z72-1", "uniprot_id": "NFIL3_CHICK", "mass": 51351.0, "length": 458, "protein_name": "Nuclear factor interleukin-3-regulated protein", "gene_name": "NFIL3", "organism": "Chicken", "refseq_name": "nuclear factor interleukin-3-regulated protein", "refseq_ac": "NP_989949", "gene_names_uniprotkb": "NFIL3; E4BP4", "gene_names_refseq": "NFIL3", "protein_names_uniprotkb": "Nuclear factor interleukin-3-regulated protein; E4 promoter-binding protein 4; bZIP protein E4BP4; cE4BP4 protein", "protein_names_refseq": "E4 promoter-binding protein 4; bZIP protein E4BP4; cE4BP4 protein; nuclear factor interleukin-3-regulated protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395326)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11427718;15182670;15306565", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267658.19316.1, SRR13267655.61710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000094.1. On Oct 17, 2021 this sequence version replaced XP_040511278.1. The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]., [RefSeq]; Acts as a transcriptional regulator (By similarity). Represses PER2 transcription through a recognition sequence in the promoter (PubMed:11427718, PubMed:15182670). Component of the circadian clock that may contribute to the rhythmic expression of PER2 gene in a light-dependent and time-of-day-dependent manner (PubMed:11427718, PubMed:15182670)., [UniProtKB, PubMed, UniProtKB, PubMed]; Pathways regulated by E4BP4 are of potential interest both for understanding neuromuscular development and for promoting neuronal survival and regeneration in pathological situations, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0006955 immune response;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90Z72-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q90ZK6-1", "uniprot_id": "ACVR1_CHICK", "mass": 56225.0, "length": 504, "protein_name": "Activin receptor type-1", "gene_name": "ACVR1", "organism": "Chicken", "refseq_name": "activin receptor type-1 isoform X7", "refseq_ac": "XP_015145616", "gene_names_uniprotkb": "ACVR1", "gene_names_refseq": "ACVR1; ALK2; ATVR1", "protein_names_uniprotkb": "Activin receptor type-1; 2.7.11.30; Activin receptor type I; Type I TGF B receptor", "protein_names_refseq": "activin receptor type-1 isoform X7", "tax_id": 9031, "disease": "", "pathway": " (gga:395246)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9YH45", "ec_number_list": "2.7.11.30", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045177 apical part of cell;GO:0048179 activin receptor complex;GO:0070724 BMP receptor complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007507 heart development;GO:0016477 cell migration;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q90ZK6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91009-1", "uniprot_id": "NTRK1_CHICK", "mass": 87339.0, "length": 778, "protein_name": "High affinity nerve growth factor receptor", "gene_name": "NTRK1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NTRK1; TRKA", "gene_names_refseq": "", "protein_names_uniprotkb": "High affinity nerve growth factor receptor; 2.7.10.1; Neurotrophic tyrosine kinase receptor type 1; Trk-A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "17967490;8892107", "class_list": "", "function": "Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors., [UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0043121 neurotrophin binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0006468 protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91018-1", "uniprot_id": "PROX1_CHICK", "mass": 83141.0, "length": 736, "protein_name": "Prospero homeobox protein 1", "gene_name": "PROX1", "organism": "Chicken", "refseq_name": "prospero homeobox protein 1", "refseq_ac": "NP_001005616", "gene_names_uniprotkb": "PROX1", "gene_names_refseq": "PROX1", "protein_names_uniprotkb": "Prospero homeobox protein 1; Homeobox prospero-like protein PROX1; PROX-1", "protein_names_refseq": "PROX-1; homeobox prospero-like protein PROX1; prospero homeobox protein 1; prospero-related homeobox 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395802)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25788138;27664768;8853985", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U46563.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U46563.1. On Dec 23, 2004 this sequence version replaced XP_419421.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Results define the neurogenesis period in the chick paravertebral sympathetic ganglia including an initial cell cycle withdrawal and identify Prox1 as a marker and regulator of proliferating sympathetic neuroblasts, [RefSeq, PubMed]; Transcription factor which may be involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. May be essential in the development and function of the eye. May play a role in the regulation of the circadian rhythm by repressing the expression of clock genes., [UniProtKB, UniProtKB, PubMed]; We show that b-catenin is expressed during the pre-patterning of the epithelium prior to papilla induction and second that b-catenin, Ednrb and Inhba are expressed during the induction and patterning of the conjunctival papillae. Furthermore, we identified two genes, b-catenin and Prox1, that may be involved in the induction of the underlying scleral bones, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0021516 dorsal spinal cord development;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91018-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91035-1", "uniprot_id": "SHH_CHICK", "mass": 46474.0, "length": 425, "protein_name": "Sonic hedgehog protein", "gene_name": "SHH", "organism": "Chicken", "refseq_name": "sonic hedgehog protein precursor", "refseq_ac": "NP_990152", "gene_names_uniprotkb": "SHH", "gene_names_refseq": "SHH; ShhNC", "protein_names_uniprotkb": "Sonic hedgehog protein; 3.1.-.-; SHH; Shh N-terminal processed signaling domains; Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; ShhNp", "protein_names_refseq": "shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; sonic hedgehog homolog; sonic hedgehog protein precursor; sonic hedgehog protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395615)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "30449599;30834718;31305241;32391617;37196093;7736596;7891723;8269518", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L28099.1, SRR13267655.175472.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN08016664 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L28099.1. Sequence Note: This sequence has been modified as follows: removed 16/16 bp suspected to be vector contamination from the 5'/3' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; AKT stimulates the Shh activity to induce lateral motor columnar motor neurons through the stabilization of ARHGAP36 proteins. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-199 family contributes to regulation of sonic hedgehog expression during craniofacial development., [RefSeq, PubMed]; Precursor of sonic hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (PubMed:7736596). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, Sonic hedgehog protein N-product and C-product (ShhN and ShhC, respectively) and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated ShhN (PubMed:7736596). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum. Following additional lipidation, ShhN acts as a morphogen, while ShhC is degraded in the endoplasmic reticulum (By similarity)., [UniProtKB, PubMed, UniProtKB]; The correct location of sonic hedgehog protein (SHH) expression is vital to the formation of the motor column., [RefSeq, PubMed]; The dually lipidated sonic hedgehog protein N-product (ShhN) is a morphogen that activates the smoothened signaling pathway, and which is essential for a variety of patterning events during development (PubMed:7736596). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (By similarity). In the absence of SHH, patched represses the constitutive signaling activity of SMO (By similarity). ShhN is widely expressed and plays a key role in the patterning of the central nervous system and limb development (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The effects of recombinant Shh and the distribution of Gli-1 during in vitro and in situ embryonic chick skeletal muscle differentiation at later stages of development., [RefSeq, PubMed]; Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.-.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0016015 morphogen activity;GO:0005113 patched binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0021508 floor plate formation;GO:0021513 spinal cord dorsal/ventral patterning", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91035-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q91987-1", "uniprot_id": "NTRK2_CHICK", "mass": 91737.0, "length": 818, "protein_name": "BDNF/NT-3 growth factors receptor", "gene_name": "NTRK2", "organism": "Chicken", "refseq_name": "BDNF/NT-3 growth factors receptor precursor", "refseq_ac": "NP_990562", "gene_names_uniprotkb": "NTRK2; TRKB", "gene_names_refseq": "NTRK2; TRKB", "protein_names_uniprotkb": "BDNF/NT-3 growth factors receptor; 2.7.10.1; Neurotrophic tyrosine kinase receptor type 2; Trk-B; TrkB tyrosine kinase", "protein_names_refseq": "BDNF/NT-3 growth factors receptor precursor; BDNF/NT-3 growth factors receptor; neurotrophic tyrosine kinase, receptor, type 2; trk-B; trkB tyrosine kinase; tyrosine kinase receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:396157)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15128848;17309801;23035107;23094873;26404565;7959025;8287802;8670834;8774442", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X77251.1, X74109.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000094.1. On Sep 23, 2021 this sequence version replaced NP_990562.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system. Publication Status: Online-Only, [RefSeq, PubMed]; Cessation of TrkB expression is essential for dendrite retraction and functional maturation of nucleus magnocellularis neurons., [RefSeq, PubMed]; Elevated BDNF expression above basal levels and signaling through TrkB in sympathoblasts may be a mechanism that contributes to the onset of neuroblastoma Publication Status: Online-Only, [RefSeq, PubMed]; Findings demonstrate roles for BDNF-induced, trk-dependent signaling in ciliary ganglion neurons, both in regulating expression of alpha7-nAChRs and in enhancing transmission at alpha3*-nAChR-mediated synapses, [RefSeq, PubMed]; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4 (PubMed:8287802, PubMed:8670834). Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:8670834). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; These results suggest that BDNF promotes the induction of imprinting through TrkB exclusively during the critical period., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q91010", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0043121 neurotrophin binding;GO:0060175 brain-derived neurotrophic factor receptor activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0005244 voltage-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030425 dendrite;GO:0043197 dendritic spine", "go_biological_process": "GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007612 learning;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91987-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92058-1", "uniprot_id": "PPBT_CHICK", "mass": 56760.0, "length": 519, "protein_name": "Alkaline phosphatase, tissue-nonspecific isozyme", "gene_name": "ALPL", "organism": "Chicken", "refseq_name": "alkaline phosphatase, tissue-nonspecific isozyme precursor", "refseq_ac": "NP_990691", "gene_names_uniprotkb": "ALPL", "gene_names_refseq": "ALPL", "protein_names_uniprotkb": "Alkaline phosphatase, tissue-nonspecific isozyme; 3.1.3.1; AP-TNAP; Phosphoamidase; TNSALP", "protein_names_refseq": "AP-TNAP; TNSALP; alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme precursor; alkaline phosphatase, tissue-nonspecific isozyme; phosphoamidase; tissue-nonspecific alkaline phosphatase", "tax_id": 9031, "disease": "", "pathway": " (gga:396317)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19543559;20026305;24204829;8563025", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.3423.1, SRR13267654.75947.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000329.1. On Oct 17, 2021 this sequence version replaced NP_990691.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (By similarity). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi) and pyridoxal 5'-phosphate (PLP) are natural substrates (By similarity). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (By similarity). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (By similarity). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Involved in the establishment and growth of feather germs (PubMed:8563025)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Tissue-nonspecific alkaline phosphatase (in matrix vesicles of chick embryos) is inhibited by lansoprazole (a noncompetitive inhibitor)., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;3.6.1.1;5.6.1.6;5.6.2.4;3.1.3.2;3.6.4.10;3.6.4.12;5.6.2.3;3.6.1.6;3.1.4.1;3.6.1.9;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.1.3.1;3.6.5.-;3.6.4.-;3.1.3.75;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.74;3.1.3.16;3.6.1.15;3.6.1.-;3.1.3.48", "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0033883 pyridoxal phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0004035 alkaline phosphatase activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0030282 bone mineralization;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q92058-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92072-1", "uniprot_id": "DNMT1_CHICK", "mass": 172907.0, "length": 1537, "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "DNMT1", "organism": "Chicken", "refseq_name": "DNA (cytosine-5)-methyltransferase 1", "refseq_ac": "NP_996835", "gene_names_uniprotkb": "DNMT1; AIM; DNMT", "gene_names_refseq": "DNMT1", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 1; 2.1.1.37; DNA MTase GgaI; DNA methyltransferase GgaI; Dnmt1; M.GgaI; MCMT", "protein_names_refseq": "DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1; DNA MTase GgaI; DNA MeTase; DNA methyltransferase GgaI; MCMT; m.GgaI", "tax_id": 9031, "disease": "", "pathway": " (gga:396011)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18648519;21559294;32504030;8586618;9302295", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D43920.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D43920.1. On Aug 30, 2004 this sequence version replaced XP_424167.1., [RefSeq]; Analysis of expression patterns and miRNA regulation of DNA methyltransferases in chicken primordial germ cells Publication Status: Online-Only, [RefSeq, PubMed]; Analysis of the potential of epigenetic alterations in DNMT1 and DNMT3a, as well as the DNA mutations in DNMT3b, as epigenetic and genetic factors to neoplastic diseases of chickens Publication Status: Online-Only, [RefSeq, PubMed]; DNA methyltransferase that methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones., [UniProtKB, UniProtKB]; In developing limbs, Dnmt1 exhibits well-defined gene expression patterns in regions destined to degenerate, such as interdigital tissues and prospective joint regions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.37;2.1.1.-", "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding;GO:0140254 histone H3K18ub reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000792 heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation;GO:0141119 chromosomal DNA methylation maintenance following DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q92072-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92075-1", "uniprot_id": "SCNNA_CHICK", "mass": 73236.0, "length": 637, "protein_name": "Epithelial sodium channel subunit alpha", "gene_name": "SCNN1A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SCNN1A; ENAC", "gene_names_refseq": "", "protein_names_uniprotkb": "Epithelial sodium channel subunit alpha; Alpha-ENaC; Alpha-NaCH; Amiloride-sensitive sodium channel subunit alpha; Epithelial Na(+) channel subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396050)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9003454", "class_list": "", "function": "This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70095;Q98941", "ec_number_list": "", "go_molecular_function": "GO:0015280 ligand-gated sodium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031514 motile cilium;GO:0016324 apical plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0055078 sodium ion homeostasis;GO:0050891 multicellular organismal-level water homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92075-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92108-1", "uniprot_id": "ANXA1_CHICK", "mass": 14398.0, "length": 130, "protein_name": "Annexin A1", "gene_name": "ANXA1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ANXA1; ANX1", "gene_names_refseq": "", "protein_names_uniprotkb": "Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8365470", "class_list": "", "function": "Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (By similarity). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0019834 phospholipase A2 inhibitor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0046883 regulation of hormone secretion;GO:0006909 phagocytosis;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92108-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92177-1", "uniprot_id": "CAN3_CHICK", "mass": 93561.0, "length": 810, "protein_name": "Calpain-3", "gene_name": "CAPN3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CAPN3", "gene_names_refseq": "", "protein_names_uniprotkb": "Calpain-3; 3.4.22.54; CANP 3; Calcium-activated neutral proteinase 3; Calpain L3; Calpain p94; Muscle-specific calcium-activated neutral protease 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7742367", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0003824 catalytic activity;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0051592 response to calcium ion;GO:0045892 negative regulation of DNA-templated transcription;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92177-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92178-1", "uniprot_id": "CAN2_CHICK", "mass": 79229.0, "length": 700, "protein_name": "Calpain-2 catalytic subunit", "gene_name": "CAPN2", "organism": "Chicken", "refseq_name": "calpain-2 catalytic subunit", "refseq_ac": "NP_990411", "gene_names_uniprotkb": "CAPN2", "gene_names_refseq": "CAPN2", "protein_names_uniprotkb": "Calpain-2 catalytic subunit; 3.4.22.53; CANP 2; Calcium-activated neutral proteinase 2; Calpain M-type; Calpain-2 large subunit; M-calpain; Millimolar-calpain", "protein_names_refseq": "CANP 2; M-calpain; calcium-activated neutral proteinase 2; calpain 2, (m/II) large subunit; calpain M-type; calpain-2 catalytic subunit; calpain-2 large subunit; calpain-2 subunit; mCL; millimolar-calpain", "tax_id": 9031, "disease": "", "pathway": " (gga:395963)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7742367", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FJ232590.1, D38026.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000062.1. On Sep 23, 2021 this sequence version replaced NP_990411.1., [RefSeq]; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006508 proteolysis;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92182-1", "uniprot_id": "SIAT1_CHICK", "mass": 47393.0, "length": 413, "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 1", "gene_name": "ST6GAL1", "organism": "Chicken", "refseq_name": "beta-galactoside alpha-2,6-sialyltransferase 1", "refseq_ac": "NP_990572", "gene_names_uniprotkb": "ST6GAL1; SIAT1", "gene_names_refseq": "ST6GAL1", "protein_names_uniprotkb": "Beta-galactoside alpha-2,6-sialyltransferase 1; 2.4.3.1; Alpha 2,6-ST 1; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 1; Gal beta 1,4 GlcNAc alpha 2,6-sialyltransferase; ST6 beta-galactosamide alpha-2,6-sialyltranferase 1; ST6 beta-galactosamide alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; alpha 2,6-ST 1; beta-galactoside alpha-2,6-sialyltransferase 1; sialyltransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396169); (R-GGA-4085001); (R-GGA-975577); (R-GGA-977068)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8307003", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X75558.1, SRR13267649.118162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ452802.1, BU358904.1, AJ452678.1, X75558.1, BU116026.1, BI392819.1 and HAEK01001982.1. Transcript Variant: This variant (1) has the short first intron., [RefSeq]; Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.3.1", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0006487 protein N-linked glycosylation;GO:0097503 sialylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92182-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92183-1", "uniprot_id": "SIA7A_CHICK", "mass": 64781.0, "length": 566, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1", "gene_name": "ST6GALNAC1", "organism": "Chicken", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1", "refseq_ac": "NP_990571", "gene_names_uniprotkb": "ST6GALNAC1; SIAT7A", "gene_names_refseq": "SIAT7A; ST6GALNAC1", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; 2.4.3.3; GalNAc alpha-2,6-sialyltransferase I; SIAT7-A; ST6GalNAc I; ST6GalNAcI; Sialyltransferase 7A", "protein_names_refseq": "SIAT7-A; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc I; ST6GalNAcI; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; alpha-N-acetylgalactosaminidealpha-2, 6-sialyltransferase; galNAc alpha-2,6-sialyltransferase I; sialyltransferase 7A", "tax_id": 9031, "disease": "", "pathway": " (gga:396168)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12010048;8288607", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X74946.1, SRR12888501.587263.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000316.1. On Sep 23, 2021 this sequence version replaced NP_990571.1., [RefSeq]; Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (By similarity). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:8288607). Generates sialylated T and Tn antigens.., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.3.3", "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0048874 host-mediated modulation of intestinal microbiota composition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q92183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98917-1", "uniprot_id": "PMEL_CHICK", "mass": 77038.0, "length": 763, "protein_name": "Melanocyte protein PMEL", "gene_name": "PMEL", "organism": "Chicken", "refseq_name": "melanocyte protein PMEL precursor", "refseq_ac": "NP_990443", "gene_names_uniprotkb": "PMEL; MMP115; PMEL17; SILV", "gene_names_refseq": "MMP115; PMEL; SILV", "protein_names_uniprotkb": "Melanocyte protein PMEL; 115 kDa melanosomal matrix protein; Melanocyte protein Pmel 17; Premelanosome protein; Silver locus protein homolog", "protein_names_refseq": "115 kDa melanosomal matrix protein; PMEL17 protein; melanocyte protein PMEL precursor; melanocyte protein Pmel 17; silver homolog; silver locus protein homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:396007)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15579702;17106652;17436332;1924173;19679373;19751488;20461577;3409326", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D88348.2, SRR13267649.72924.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02738217, SAMN02738218 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000490.1. On Sep 23, 2021 this sequence version replaced NP_990443.2., [RefSeq]; Dominant white is exclusively associated with a 9-bp insertion in exon 10, Dun is associated with a deletion of 15-bp in exon 10, and Smoky has the same 9-bp insertion as Dominant white as well as a 12-bp deletion in exon 6 of PMEL17., [RefSeq, PubMed]; Dominant white mutation does not cause visual impairment, [RefSeq, PubMed]; Genotype of PMEL17 affects plumage color and feather pecking behavior., [RefSeq, PubMed]; In addition to the 9-bp insertion, WLs and KOCs have unique bases in single nucleotide polymorphisms (SNPs) at the 1,777th and 3,118th bases in the PMEL17 gene., [RefSeq, PubMed]; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymatic function of tyrosinase., [UniProtKB]; The study strongly suggests a correlated effect between plumage colour and behaviour, and we conclude that PMEL17 may have a pleiotropic effect on social and explorative behaviour in chickens., [RefSeq, PubMed]; The transmembrane region may contribute to the structural integrity of Silver/Pmel17 oligomers or influence toxic, amyloidogenic properties, [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 5, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q6DW60;Q6DW61;Q6DW62;Q6DW63;Q6DW64;Q6DW65", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042470 melanosome;GO:0034493 melanosome lumen", "go_biological_process": "GO:0032438 melanosome organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q98917-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98930-1", "uniprot_id": "SORL_CHICK", "mass": 178411.0, "length": 1592, "protein_name": "Sortilin-related receptor", "gene_name": "SORL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SORL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sortilin-related receptor; LDLR relative with 11 ligand-binding repeats; LR11; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; SorLA-1; SorLA; Sorting protein-related receptor containing LDLR class A repeats", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9157966", "class_list": "", "function": "Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (By similarity). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (By similarity). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling (By similarity). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (By similarity). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (By similarity). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue (By similarity). Plays a role in renal ion homeostasis, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR, hence facilitating the proteolysis of the extracellular matrix (By similarity). May also stimulate the proliferation, adhesion and migration of monocytes/macrophages (By similarity). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet (By similarity). Sorting receptor that may regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (By similarity). May regulate IL6 signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0006897 endocytosis;GO:0006605 protein targeting;GO:0006622 protein targeting to lysosome;GO:0006892 post-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q98930-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98938-1", "uniprot_id": "IHH_CHICK", "mass": 44829.0, "length": 408, "protein_name": "Indian hedgehog protein", "gene_name": "IHH", "organism": "Chicken", "refseq_name": "indian hedgehog protein precursor", "refseq_ac": "NP_990288", "gene_names_uniprotkb": "IHH", "gene_names_refseq": "IHH", "protein_names_uniprotkb": "Indian hedgehog protein; 3.1.-.-; IHH", "protein_names_refseq": "indian hedgehog protein precursor; indian hedgehog protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395801); (R-GGA-5358346); (R-GGA-5362798); (R-GGA-5632681)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12968668;14991716;21683695;23928032;8662546", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U58511.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000236.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; BMPs are integrated into the Ihh/PTHrP signaling loop, and a fine balance of BMP signaling is essential for normal chondrocyte maturation and skeletal development., [RefSeq, PubMed]; Based on these results, the Ihh signal is essential for balancing chicken chondrocyte proliferation and hypertrophy, and the regulatory function of PTHrP acts in an Ihh-dependent manner., [RefSeq, PubMed]; Indian hedgehog and syndecan-3 have roles in chondrocyte proliferation and limb skeletogenesis, [RefSeq, PubMed]; Precursor of indian hedgehog, a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (PubMed:8662546). The C-terminal part of the precursor displays an autoproteolysis and a cholesterol transferase activity, resulting (1) in the cleavage of the full-length protein into two parts, indian hedgehog protein N-product and C-product and (2) covalent attachment of a cholesterol moiety to the C-terminus of the newly generated N-product (By similarity). Both autoproteolysis and a cholesterol transferase activities occur in the endoplasmic reticulum. Following additional lipidation, N-product acts as a morphogen, while C-product is degraded in the endoplasmic reticulum (By similarity)., [UniProtKB, PubMed, UniProtKB]; Reduction of Ihh in chicken embryo hindlimbs reduced skeletal muscle mass similar to that seen in Ihh(-/-) mouse embryos, [RefSeq, PubMed]; The dually lipidated indian hedgehog protein N-product is a morphogen that activates the smoothened signaling pathway, and which is essential for bone and cartilage development (PubMed:8662546). Acts by binding to the patched receptor (PTCH1 or PTCH2), relieving smoothened (SMO) inhibition by patched, activating the smoothened signaling pathway and transcription of target genes (By similarity). In the absence of IHH, patched represses the constitutive signaling activity of SMO (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (PubMed:8662546). Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy (PubMed:8662546). In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (PubMed:8662546)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;3.6.4.6;5.3.4.1;3.1.-.-", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0005113 patched binding;GO:0034189 very-low-density lipoprotein particle binding;GO:0140853 cholesterol-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0046639 negative regulation of alpha-beta T cell differentiation;GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q98938-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98943-1", "uniprot_id": "CASP2_CHICK", "mass": 47960.0, "length": 424, "protein_name": "Caspase-2", "gene_name": "CASP2", "organism": "Chicken", "refseq_name": "caspase-2", "refseq_ac": "NP_001161173", "gene_names_uniprotkb": "CASP2; ICH1", "gene_names_refseq": "CASP-2; CASP2; ICH-1L/1S; ICH1L1S; ICH1", "protein_names_uniprotkb": "Caspase-2; 3.4.22.55; CASP-2; ICH-1L/1S; Protease ICH-1", "protein_names_refseq": "ICH1 protease; caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2); caspase 2, apoptosis-related cysteine protease; caspase-2; cysteine protease caspase-2; protease ICH-1", "tax_id": 9031, "disease": "", "pathway": " (gga:395857)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14975933;9224894", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.269521.1, SRR13267652.26450.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000015.1. On Sep 23, 2021 this sequence version replaced NP_001161173.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Active caspase-2 initiates cytochrome c release after reperfusion and that it is critical for myocardial ischemia reperfusion-induced apoptosis, [RefSeq, PubMed]; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0016485 protein processing;GO:0006915 apoptotic process;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0043525 positive regulation of neuron apoptotic process;GO:0071260 cellular response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q98943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98949-1", "uniprot_id": "TYRO3_CHICK", "mass": 96402.0, "length": 873, "protein_name": "Tyrosine-protein kinase receptor TYRO3", "gene_name": "TYRO3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TYRO3; REK", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor TYRO3; 2.7.10.1; Rek; Retina-expressed kinase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395336)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8910558", "class_list": "", "function": "Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, enhances PI3-kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q98949-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q98UI9-1", "uniprot_id": "MUC5B_CHICK", "mass": 233553.0, "length": 2108, "protein_name": "Mucin-5B", "gene_name": "MUC5B", "organism": "Chicken", "refseq_name": "ovomucin precursor", "refseq_ac": "NP_989992", "gene_names_uniprotkb": "MUC5B", "gene_names_refseq": "MUC5B; OVOA; alpha-ovomucin; alpha-subunit", "protein_names_uniprotkb": "Mucin-5B; Ovomucin, alpha-subunit", "protein_names_refseq": "mucin-5B oligomeric mucus/gel-forming; ovomucin precursor; ovomucin, alpha subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:395381)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15620212;21484392;2705776;5119791;6749856", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB046524.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB046524.1., [RefSeq]; Authors measure the kinetics of ovomucin mRNA binding to microsomes during translation & nascent chain elongation rates., [RefSeq, PubMed]; Dissociates the ovomucin complex into its constituent alpha & beta proteins and determine the composition of sugars for each protein, [RefSeq, PubMed]; Identified 18 potential N-glycosylation sites in alpha-ovomucin; glycans from alpha-ovomucin glycopeptides had a pentasaccaride core of GlcNAc2Man3, which is characteristic to N-linked glycans, and a bisecting GlcNAc common to other egg white proteins, [RefSeq, PubMed]; Investigated the physical properties of mucin gel formation., [RefSeq, PubMed]; Ovomucin, the glycoprotein responsible for the gel properties of egg white, is composed for 2 subunits, alpha-ovomucin/MUC5B and beta-ovomucin/MUC6., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 16, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 16, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 16, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0046790 virion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0030299 intestinal cholesterol absorption;GO:0042632 cholesterol homeostasis;GO:0002281 macrophage activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q98UI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DD78-1", "uniprot_id": "TLR21_CHICK", "mass": 90767.0, "length": 793, "protein_name": "Toll-like receptor 2 type-1", "gene_name": "TLR2-1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TLR2-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Toll-like receptor 2 type-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374141); (R-GGA-433822); (R-GGA-451514); (R-GGA-517856)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "11460167;11590137;11923871;11960013;12447442;12855817;14625308;14633987;16260493;17135271;17496917;17513760;17878161;18070982;18438411;18582498;19224918;19675569", "class_list": "", "function": "Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042497 triacyl lipopeptide binding;GO:0004888 transmembrane signaling receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9DD78-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DDD0-1", "uniprot_id": "NRX1A_CHICK", "mass": 150076.0, "length": 1363, "protein_name": "Neurexin-1", "gene_name": "NRXN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NRXN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurexin-1; Neurexin I-alpha; Neurexin-1-alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10860582", "class_list": "", "function": "Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0097109 neuroligin family protein binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0098820 trans-synaptic protein complex", "go_biological_process": "GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DDD0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DER5-1", "uniprot_id": "TEN2_CHICK", "mass": 310749.0, "length": 2802, "protein_name": "Teneurin-2", "gene_name": "TENM2", "organism": "Chicken", "refseq_name": "teneurin-2 isoform 1", "refseq_ac": "NP_989428", "gene_names_uniprotkb": "TENM2; ODZ2; TNM2", "gene_names_refseq": "ODZ2; TEN2; TENM2", "protein_names_uniprotkb": "Teneurin-2; Neurestin; Protein Odd Oz/ten-m homolog 2; Ten-2; Ten-m2; Tenascin-M2; Teneurin transmembrane protein 2", "protein_names_refseq": "neurestin; odd Oz/ten-m homolog 2; odz, odd Oz/ten-m homolog 2; protein Odd Oz/ten-m homolog 2; ten-2; ten-m2; tenascin-M2; teneurin-2 isoform 1; teneurin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:373854)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10588872;11146505;12361962;12783990;18366734", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ279031.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ279031.1, BU119898.1, BU114356.1 and BU346611.1. On or before Aug 30, 2004 this sequence version replaced XP_414498.1, NP_989428.1. Transcript Variant: This variant (1) encodes the longer isoform (1)., [RefSeq]; Induces gene transcription inhibition., [UniProtKB, PubMed]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system (PubMed:10588872, PubMed:12361962). Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells (By similarity). Promotes the formation of filopodia and enlarged growth cone in neuronal cells (PubMed:10588872, PubMed:12361962). Mediates axon guidance and homophilic and heterophilic cell-cell adhesion (PubMed:10588872, PubMed:12361962). May function as a cellular signal transducer (PubMed:10588872, PubMed:12361962)., [UniProtKB, PubMed, PubMed, UniProtKB]; Teneurin-1 and -2 are expressed by distinct interconnected populations of neurons in the developing central nervous system Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q9PU49", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0098609 cell-cell adhesion;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9DER5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DF69-1", "uniprot_id": "CSPG5_CHICK", "mass": 61376.0, "length": 594, "protein_name": "Chondroitin sulfate proteoglycan 5", "gene_name": "CSPG5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CSPG5; CALEB", "gene_names_refseq": "", "protein_names_uniprotkb": "Chondroitin sulfate proteoglycan 5; Acidic leucine-rich EGF-like domain-containing brain protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395466)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11069908;14622101;15848802;9049254", "class_list": "", "function": "May function as a growth and differentiation factor involved in neuritogenesis and more particularly in neurite extension., [UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 4, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O13003", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0031103 axon regeneration;GO:0106091 glial cell projection elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DF69-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9DGG6-1", "uniprot_id": "ADCY9_CHICK", "mass": 149292.0, "length": 1334, "protein_name": "Adenylate cyclase type 9", "gene_name": "ADCY9", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADCY9", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylate cyclase type 9; 4.6.1.1; ATP pyrophosphate-lyase 9; Adenylate cyclase type IX; Adenylyl cyclase 9", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11322775", "class_list": "", "function": "Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.6.1.1", "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DGG6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I920-1", "uniprot_id": "BLM_CHICK", "mass": 130294.0, "length": 1183, "protein_name": "RecQ-like DNA helicase BLM", "gene_name": "BLM", "organism": "Chicken", "refseq_name": "recQ-like DNA helicase BLM", "refseq_ac": "NP_001007088", "gene_names_uniprotkb": "BLM", "gene_names_refseq": "BLM; ORF1", "protein_names_uniprotkb": "RecQ-like DNA helicase BLM; 5.6.2.4; Bloom syndrome protein homolog; DNA 3'-5' helicase BLM; RecQ helicase homolog", "protein_names_refseq": "BLM helicase; Bloom syndrome, RecQ helicase-like; DNA 3'-5' helicase BLM; Gd BLM; recQ helicase homolog; recQ-like DNA helicase BLM", "tax_id": 9031, "disease": "", "pathway": " (gga:415577)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10880455;14985700;15642098;16880537;17283053;19661064;28228481;28338731", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720413.1, AB032092.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000246.1. On Sep 23, 2021 this sequence version replaced NP_001007088.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:28228481). Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA (PubMed:28228481). Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity)., [UniProtKB, UniProtKB, PubMed]; BLM is assembled from dimer into hexamer, and also, the stable DHBN dimer can be dissociated upon ATP hydrolysis. Thus, the structural and biochemical characterizations of N-terminal domains will provide new insights into how the N-terminal domain affects the structural and functional organization of the full BLM molecule., [RefSeq, PubMed]; Disruption of the BLM gene in ATM-null DT40 cells (a B-lymphocyte cell line)does not exacerbate either phenotype., [RefSeq, PubMed]; First enzymatic characterization of chicken BLM and its N-terminal domain, [RefSeq, PubMed]; Results show that Blm promotes HR between diverged sequences through a novel ATPase-independent mechanism., [RefSeq, PubMed]; These data indicate that BLM and Top3alpha execute the dissolution of sister chromatids., [RefSeq, PubMed]; These data suggest that Fbh1 acts in parallel with Bloom helicase to control recombination-mediated double-strand-break repair at replication blocks and to reduce the frequency of crossover., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZJM1", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0051260 protein homooligomerization;GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9I920-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I993-1", "uniprot_id": "BCDO1_CHICK", "mass": 60385.0, "length": 526, "protein_name": "Beta,beta-carotene 15,15'-dioxygenase", "gene_name": "BCO1", "organism": "Chicken", "refseq_name": "beta,beta-carotene 15,15'-dioxygenase", "refseq_ac": "NP_001351831", "gene_names_uniprotkb": "BCO1; BCDO; BCMO1", "gene_names_refseq": "BCDO; BCMO1; BCO1", "protein_names_uniprotkb": "Beta,beta-carotene 15,15'-dioxygenase; 1.13.11.63; Beta-carotene dioxygenase 1; Beta-carotene oxygenase 1", "protein_names_refseq": "beta,beta-carotene 15,15'-dioxygenase; beta,beta-carotene 15,15'-monooxygenase; beta-carotene 15,15'-dioxygenase; beta-carotene 15,15'-monooxygenase 1; beta-carotene dioxygenase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395346); (R-GGA-975634)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10799297;11237856;17890117;21750696;23125440;24642187;28625776", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267656.27063.1, ERR2365565.153133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Jul 13, 2018 this sequence version replaced XP_015148005.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Data indicate taht two fully-linked single nucleotide polymorphisms (SNP) located within the proximal promoter of BCMO1 gene were identified. Erratum:[PLoS One. 2011;6(9). doi: 10.1371/annotation/17f0c1e7-7cca-4886-9f0b-3891ab2dc128], [RefSeq, PubMed]; Genetic association study in domestic chickens in France: Data suggest that two SNPs in BCMO1 promoter are associated with higher absorption of dietary beta-carotene in duodenum and reduced absorption of xanthophylls/liposoluble vitamins/cholesterol., [RefSeq, PubMed]; Observed that in myoblast showing decreased BCO1 expression consecutive to a natural mutation or to a siRNA treatment, [RefSeq, PubMed]; Postnatal induction of BCMO1 gene expression in the chick duodenum may be caused by the elevation of serum hydrocortisone levels and may contribute to the RALDH1-mediated retinoic acid synthetic pathway., [RefSeq, PubMed]; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism., [UniProtKB, PubMed]; These results indicated that a genetic variant of BCMO1 specifically changes lutein and zeaxanthin content in the chicken plasma and breast muscle without impairing vitamin A and E metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.13.11.63", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0010436 carotenoid dioxygenase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0032526 response to retinoic acid;GO:0042574 retinal metabolic process;GO:1901810 beta-carotene metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9I993-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9I9E0-1", "uniprot_id": "TAOK3_CHICK", "mass": 105459.0, "length": 898, "protein_name": "Serine/threonine-protein kinase TAO3", "gene_name": "TAOK3", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase TAO3 isoform 1", "refseq_ac": "NP_001012541", "gene_names_uniprotkb": "TAOK3; KFC; RCJMB04_21d18", "gene_names_refseq": "TAOK3", "protein_names_uniprotkb": "Serine/threonine-protein kinase TAO3; 2.7.11.1; Kinase from chicken; Thousand and one amino acid protein 3", "protein_names_refseq": "KFC; kinase from chicken; serine/threonine-protein kinase TAO3 isoform 1; serine/threonine-protein kinase TAO3; thousand and one amino acid protein 3", "tax_id": 9031, "disease": "", "pathway": " (gga:395499)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10698516;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851723.1, SRR13267659.195183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1. On Oct 5, 2021 this sequence version replaced NP_001012541.1., [RefSeq]; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP kinase kinases. Inhibits basal activity of the MAPK8/JNK cascade (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5F3C7", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016740 transferase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006281 DNA repair;GO:0046330 positive regulation of JNK cascade;GO:0000165 MAPK cascade;GO:0048812 neuron projection morphogenesis;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I9E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IA88-1", "uniprot_id": "SIK2_CHICK", "mass": 88866.0, "length": 798, "protein_name": "Serine/threonine-protein kinase SIK2", "gene_name": "SIK2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SIK2; QIK; SNF1LK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase SIK2; 2.7.11.1; Qin-induced kinase; SIK-2; Salt-inducible kinase 2; Serine/threonine-protein kinase SNF1-like kinase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395417)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11027514", "class_list": "", "function": "Phosphorylates IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization;GO:0046626 regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9IA88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IAL7-1", "uniprot_id": "NCKX2_CHICK", "mass": 72696.0, "length": 651, "protein_name": "Sodium/potassium/calcium exchanger 2", "gene_name": "SLC24A2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC24A2; NCKX2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 2; Na(+)/K(+)/Ca(2+)-exchange protein 2; Retinal cone Na-Ca+K exchanger; Solute carrier family 24 member 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:414891)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10662833", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10662833). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9IAL6", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060292 long-term synaptic depression;GO:0070588 calcium ion transmembrane transport;GO:0060291 long-term synaptic potentiation;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9IAL7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IAL8-1", "uniprot_id": "NCKX1_CHICK", "mass": 73772.0, "length": 663, "protein_name": "Sodium/potassium/calcium exchanger 1", "gene_name": "SLC24A1", "organism": "Chicken", "refseq_name": "sodium/potassium/calcium exchanger 1", "refseq_ac": "NP_001001773", "gene_names_uniprotkb": "SLC24A1; NCKX1", "gene_names_refseq": "NCKX1; SLC24A1", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; Retinal rod Na-Ca+K exchanger; Solute carrier family 24 member 1", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 1; potassium-dependent socium-calcium exchanger; retinal rod Na-Ca+K exchanger; sodium/potassium/calcium exchanger 1; solute carrier family 24 (sodium/potassium/calcium exchanger), member 1", "tax_id": 9031, "disease": "", "pathway": " (gga:414892)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10662833", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF177984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000246.1. On Oct 1, 2021 this sequence version replaced NP_001001773.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10662833). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060292 long-term synaptic depression;GO:0007601 visual perception;GO:0070588 calcium ion transmembrane transport;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9IAL8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9IAX2-1", "uniprot_id": "IOD2_CHICK", "mass": 31033.0, "length": 279, "protein_name": "Type II iodothyronine deiodinase", "gene_name": "DIO2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DIO2", "gene_names_refseq": "", "protein_names_uniprotkb": "Type II iodothyronine deiodinase; 1.21.99.4; 5DII; DIOII; Type 2 DI; Type-II 5'-deiodinase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10318780", "class_list": "", "function": "Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:10318780). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via outer-ring deiodination (ORD) (PubMed:10318780). Catalyzes the deiodination of 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via ORD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.21.99.3;1.21.99.4", "go_molecular_function": "GO:0004800 thyroxine 5'-deiodinase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0042446 hormone biosynthetic process;GO:0006590 thyroid hormone generation;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9IAX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PRS8-1", "uniprot_id": "OC17_CHICK", "mass": 15300.0, "length": 142, "protein_name": "Ovocleidin-17", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ovocleidin-17; OC-17", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10410246;12144522;7648490", "class_list": "", "function": "May form proteinaceous networks during the construction of the eggshell which then may control the deposition of the mineral phase., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0042834 peptidoglycan binding;GO:0030246 carbohydrate binding;GO:0001530 lipopolysaccharide binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:1990377 organomineral extracellular matrix", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0031214 biomineral tissue development;GO:0019730 antimicrobial humoral response;GO:0031215 shell calcification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9PRS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PSW9-1", "uniprot_id": "H2B8_CHICK", "mass": 13964.0, "length": 126, "protein_name": "Histone H2B 8", "gene_name": "H2B-VIII", "organism": "Chicken", "refseq_name": "histone H2B 8", "refseq_ac": "NP_001026652", "gene_names_uniprotkb": "H2B-VIII", "gene_names_refseq": "H2B-VIII; H2BC38; HIST1H2B8; HIST1H2BO", "protein_names_uniprotkb": "Histone H2B 8; H2B VIII", "protein_names_refseq": "H2B VIII; histone H2B 8; histone cluster 1, H2B-VIII; histone cluster 1, H2bo", "tax_id": 9031, "disease": "", "pathway": " (gga:427886); (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-3214847); (R-GGA-427413); (R-GGA-5250924); (R-GGA-5689880); (R-GGA-5693565); (R-GGA-5693571); (R-GGA-5693607); (R-GGA-606279); (R-GGA-68616); (R-GGA-69473); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 27, "publication_count": 5, "publication_id_list": "12757711;12865423;2471062;2713375;8804862", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: HAEK01143865.1, HAEL01012304.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Aug 8, 2005 this sequence version replaced XP_425460.1., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9PSW9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PU47-1", "uniprot_id": "PDLI3_CHICK", "mass": 34365.0, "length": 315, "protein_name": "PDZ and LIM domain protein 3", "gene_name": "PDLIM3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PDLIM3; ALP", "gene_names_refseq": "", "protein_names_uniprotkb": "PDZ and LIM domain protein 3; Alpha-actinin-associated LIM protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:414873)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10506181", "class_list": "", "function": "May play a role in the organization of actin filament arrays within muscle cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9PU46", "ec_number_list": "", "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0001725 stress fiber", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9PU47-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PU53-1", "uniprot_id": "TERF2_CHICK", "mass": 80163.0, "length": 718, "protein_name": "Telomeric repeat-binding factor 2", "gene_name": "TERF2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TERF2; TRF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395598); (R-GGA-418124)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10338214;10571037;14659874;14966288;15383534;16943437;18587156", "class_list": "", "function": "Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes (By similarity). In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo (By similarity). Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection (By similarity). Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (By similarity). Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair (By similarity). Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo (By similarity). Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology (By similarity). Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0042803 protein homodimerization activity;GO:0042162 telomeric DNA binding;GO:0003691 double-stranded telomeric DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0070187 shelterin complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006278 RNA-templated DNA biosynthetic process;GO:0000723 telomere maintenance;GO:0031848 protection from non-homologous end joining at telomere;GO:0070198 protein localization to chromosome, telomeric region;GO:0061820 telomeric D-loop disassembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9PU53-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PUF6-1", "uniprot_id": "PGFRA_CHICK", "mass": 122941.0, "length": 1087, "protein_name": "Platelet-derived growth factor receptor alpha", "gene_name": "PDGFRA", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PDGFRA", "gene_names_refseq": "", "protein_names_uniprotkb": "Platelet-derived growth factor receptor alpha; 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; PDGF-R-alpha; PDGFR-alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10842055;18192285", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;2.7.11.1;2.7.10.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0005018 platelet-derived growth factor alpha-receptor activity;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043235 receptor complex", "go_biological_process": "GO:0006935 chemotaxis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9PUF6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PW38-1", "uniprot_id": "GEPH_CHICK", "mass": 79721.0, "length": 736, "protein_name": "Gephyrin", "gene_name": "GPHN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GPHN", "gene_names_refseq": "", "protein_names_uniprotkb": "Gephyrin; Domain E; Domain G; Mo insertase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10649567", "class_list": "", "function": "Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB]; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (Probable). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.10.1.1;2.7.7.75", "go_molecular_function": "GO:0061598 molybdopterin adenylyltransferase activity;GO:0061599 molybdopterin molybdotransferase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0072579 glycine receptor clustering;GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9PW38-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PWB0-1", "uniprot_id": "CER1_CHICK", "mass": 31225.0, "length": 272, "protein_name": "Cerberus", "gene_name": "CER1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CER1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cerberus", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-201451)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10508582", "class_list": "", "function": "Cytokine that acts as a regulator of the activity of Nodal/BMP pathways during the establishment of bilateral asymmetry in the head and trunk of the embryo., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0016015 morphogen activity;GO:0036122 BMP binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0003140 determination of left/right asymmetry in lateral mesoderm;GO:1900108 negative regulation of nodal signaling pathway;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9PWB0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PWE8-1", "uniprot_id": "TBX5_CHICK", "mass": 58402.0, "length": 521, "protein_name": "T-box transcription factor TBX5", "gene_name": "TBX5", "organism": "Chicken", "refseq_name": "T-box transcription factor TBX5", "refseq_ac": "NP_989504", "gene_names_uniprotkb": "TBX5", "gene_names_refseq": "TBX5", "protein_names_uniprotkb": "T-box transcription factor TBX5; T-box protein 5", "protein_names_refseq": "T-box protein 5; T-box transcription factor TBX5", "tax_id": 9031, "disease": "", "pathway": " (gga:373988)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10373308;24651482;26212321;32344429;32344431;9550719", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF069396.2, SRR13267649.189113.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF069396.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. May bind to the core DNA motif of promoters., [UniProtKB, UniProtKB]; Forelimb-restricted expression of Tbx5 and ultimately forelimb formation is therefore achieved through co-option of two characteristics of Hox genes; their colinear expression along the body axis and the functional specificity of different paralogs. Publication Status: Online-Only, [RefSeq, PubMed]; Mutations Upstream of the TBX5 and PITX1 Transcription Factor Genes Are Associated with Feathered Legs in the Domestic Chicken., [RefSeq, PubMed]; Parallel Genetic Origin of Foot Feathering in Birds., [RefSeq, PubMed]; Tbx5 and Tbx4 expression in forelimb and hindlimb, respectively, are not sufficient for limb outgrowth and that input from RA is required., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O73719", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0051087 protein-folding chaperone binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0001708 cell fate specification;GO:0051891 positive regulation of cardioblast differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9PWE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9PWH2-1", "uniprot_id": "FZD10_CHICK", "mass": 65945.0, "length": 585, "protein_name": "Frizzled-10", "gene_name": "FZD10", "organism": "Chicken", "refseq_name": "frizzled-10 precursor", "refseq_ac": "NP_989429", "gene_names_uniprotkb": "FZD10; FZ10", "gene_names_refseq": "FZD10; cFz-10", "protein_names_uniprotkb": "Frizzled-10; Fz-10; cFz-10", "protein_names_refseq": "frizzled 10, seven transmembrane spanning receptor; frizzled family receptor 10; frizzled homolog 10; frizzled-10 precursor; frizzled-10; fz-10", "tax_id": 9031, "disease": "", "pathway": " (gga:373885)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10704868;10781956;11142678;24599775;32531778", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AF224320.1, AB023806.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF224320.1., [RefSeq]; Expressed in the dorsal neural tube and dorsal limb bud, overlapping with Wnt7a expression, and functionally interacting with Wnt7a, but not with Wnt3a, [RefSeq, PubMed]; FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cord. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. Activation by WNT7A induces expression of beta-catenin target genes (PubMed:11142678). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:11142678). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)., [UniProtKB, PubMed]; Results identify FZD10 as a receptor for WNT1 and WNT3A in the developing chick spinal cord., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0060070 canonical Wnt signaling pathway;GO:0035567 non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9PWH2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6V5-1", "uniprot_id": "PTPRJ_CHICK", "mass": 154214.0, "length": 1406, "protein_name": "Receptor-type tyrosine-protein phosphatase eta", "gene_name": "PTPRJ", "organism": "Chicken", "refseq_name": "receptor-type tyrosine-protein phosphatase eta precursor", "refseq_ac": "NP_989952", "gene_names_uniprotkb": "PTPRJ", "gene_names_refseq": "PTPRJ", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase eta; 3.1.3.48; HPTP eta; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; R-PTP-eta; Supporting-cell antigen", "protein_names_refseq": "HPTP eta; R-PTP-J; R-PTP-eta; protein-tyrosine phosphatase eta; receptor-type tyrosine-protein phosphatase eta precursor; receptor-type tyrosine-protein phosphatase eta; supporting-cell antigen", "tax_id": 9031, "disease": "", "pathway": " (gga:395330)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10366616", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Sep 23, 2021 this sequence version replaced NP_989952.1., [RefSeq]; Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of several substrates (By similarity). Plays a role in cell adhesion, migration, proliferation and differentiation (By similarity). Has a role in megakaryocytes and platelet formation. May influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells (PubMed:10366616)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 37, "predicted_n_glycosites": 37, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 37, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.67;3.1.3.21;3.1.3.18;3.1.3.2", "go_molecular_function": "GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0032587 ruffle membrane", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0051894 positive regulation of focal adhesion assembly;GO:0030220 platelet formation;GO:0043407 negative regulation of MAP kinase activity;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W6V5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W6V6-1", "uniprot_id": "TEN1_CHICK", "mass": 302388.0, "length": 2705, "protein_name": "Teneurin-1", "gene_name": "TENM1", "organism": "Chicken", "refseq_name": "teneurin-1", "refseq_ac": "NP_990193", "gene_names_uniprotkb": "TENM1; ODZ1; TNM1", "gene_names_refseq": "ODZ1; TEN-1; TENM1; ten-m1", "protein_names_uniprotkb": "Teneurin-1; Protein Odd Oz/ten-m homolog 1; Ten-1 ECD; Ten-1 extracellular domain; Ten-1; Ten-m1; Tenascin-M1; Teneurin transmembrane protein 1", "protein_names_refseq": "odz, odd Oz/ten-m homolog 1(Drosophila); protein Odd Oz/ten-m homolog 1; tenascin-M1; teneurin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:395668)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10341219;15777793;18366734", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: AJ238613.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1. On or before Dec 8, 2021 this sequence version replaced XP_015133677.1, NP_990193.1., [RefSeq]; Induces gene transcription activation., [UniProtKB, PubMed]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity)., [UniProtKB]; Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade (By similarity)., [UniProtKB]; Teneurin-1 and -2 are expressed by distinct interconnected populations of neurons in the developing central nervous system Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 13, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007218 neuropeptide signaling pathway;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0090316 positive regulation of intracellular protein transport;GO:0043406 positive regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W6V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W734-1", "uniprot_id": "SMAD6_CHICK", "mass": 47824.0, "length": 431, "protein_name": "SMAD family member 6", "gene_name": "SMAD6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SMAD6; MADH6", "gene_names_refseq": "", "protein_names_uniprotkb": "SMAD family member 6; MAD homolog 6; Mothers against DPP homolog 6; Mothers against decapentaplegic homolog 6; SMAD 6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10525349", "class_list": "", "function": "Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of pro-inflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0070411 I-SMAD binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005768 endosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W734-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9W7C5-1", "uniprot_id": "HBEGF_CHICK", "mass": 22541.0, "length": 212, "protein_name": "Proheparin-binding EGF-like growth factor", "gene_name": "HBEGF", "organism": "Chicken", "refseq_name": "proheparin-binding EGF-like growth factor precursor", "refseq_ac": "NP_990180", "gene_names_uniprotkb": "HBEGF; HEGFL", "gene_names_refseq": "HB-EGF; HBEGF; HEGFL", "protein_names_uniprotkb": "Proheparin-binding EGF-like growth factor", "protein_names_refseq": "proheparin-binding EGF-like growth factor precursor; proheparin-binding EGF-like growth factor", "tax_id": 9031, "disease": "", "pathway": " (gga:395654); (R-GGA-1227986); (R-GGA-1236394); (R-GGA-1250196); (R-GGA-1250342); (R-GGA-1250347); (R-GGA-1257604); (R-GGA-177929); (R-GGA-179812); (R-GGA-180292); (R-GGA-180336); (R-GGA-182971); (R-GGA-1963640); (R-GGA-1963642); (R-GGA-212718); (R-GGA-2179392); (R-GGA-5673001); (R-GGA-6785631); (R-GGA-6811558); (R-GGA-8856825); (R-GGA-8856828); (R-GGA-8857538); (R-GGA-8863795); (R-GGA-9009391)", "pathway_count": 24, "publication_count": 2, "publication_id_list": "10318950;17229890", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF131224.1, BU465155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000254.1., [RefSeq]; CNIH2 gene facilitated the secretion of HB-EGF in the developing chick brain, [RefSeq, PubMed]; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic transformation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008201 heparin binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0021545 cranial nerve development;GO:0008284 positive regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051549 positive regulation of keratinocyte migration;GO:0048661 positive regulation of smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W7C5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YGC1-1", "uniprot_id": "BLNK_CHICK", "mass": 61823.0, "length": 552, "protein_name": "B-cell linker protein", "gene_name": "BLNK", "organism": "Chicken", "refseq_name": "B-cell linker protein", "refseq_ac": "NP_990239", "gene_names_uniprotkb": "BLNK; BASH", "gene_names_refseq": "BASH; BLNK; SH2D6", "protein_names_uniprotkb": "B-cell linker protein; B-cell adapter SH2 domain-containing protein; Cytoplasmic adapter protein; SLP-65; Src homology 2 domain-containing leukocyte protein of 65 kDa", "protein_names_refseq": "B cell linker protein BLNK; B-cell adapter SH2 domain-containing protein; B-cell linker protein; SLP-65; cytoplasmic adapter protein; src homology 2 domain-containing leukocyte protein of 65 kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:395733)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10023776;11434777;12456653;16912232;17681949;19218240;19945479;9834055", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF089727.1, AB015289.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000232.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; BLNK recruits active H-Ras to the BCR complex, which is essential for sustained surface expression of BCR in the form of the cap and for the signal leading to functional ERK activation, [RefSeq, PubMed]; Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays a critical role in B-cell development in the bursa. Plays an important role in BCR-induced apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; In hydrogen peroxide-stimulated DT40 cells, BLNK is phosphorylated by Syk and not by Btk., [RefSeq, PubMed]; Microarray analysis of SCA-2 induced bursal cells showed BLNK to be among the under-expressed genes and this was validated with qRT-PCR., [RefSeq, PubMed]; Short SLP-65 isoform promotes BCR-induced B-cell apoptosis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0035473 lipase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction;GO:0050853 B cell receptor signaling pathway;GO:0030183 B cell differentiation;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9YGC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YGL6-1", "uniprot_id": "PALM_CHICK", "mass": 42125.0, "length": 386, "protein_name": "Paralemmin-1", "gene_name": "PALM", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PALM", "gene_names_refseq": "", "protein_names_uniprotkb": "Paralemmin-1; Paralemmin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12874826;9813098", "class_list": "", "function": "Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9YGL4;Q9YGL5", "ec_number_list": "", "go_molecular_function": "GO:0031750 D3 dopamine receptor binding", "go_cellular_component": "GO:0005622 intracellular anatomical structure;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity;GO:0072659 protein localization to plasma membrane;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9YGL6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YGX2-1", "uniprot_id": "RPE65_CHICK", "mass": 60930.0, "length": 533, "protein_name": "Retinoid isomerohydrolase", "gene_name": "RPE65", "organism": "Chicken", "refseq_name": "retinoid isomerohydrolase", "refseq_ac": "NP_990215", "gene_names_uniprotkb": "RPE65", "gene_names_refseq": "RPE65", "protein_names_uniprotkb": "Retinoid isomerohydrolase; 3.1.1.64; 5.3.3.22; All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; Retinal pigment epithelium-specific 65 kDa protein; Retinol isomerase", "protein_names_refseq": "all-trans-retinyl-palmitate hydrolase; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65kDa; retinoid isomerohydrolase; retinol isomerase", "tax_id": 9031, "disease": "", "pathway": " (gga:395700)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18216020;19490105;19892706;21446919;25112876;28874556", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB017594.1, ERR2368565.205717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992531 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1., [RefSeq]; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:19490105). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (By similarity). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; RPE65 from the cone-dominant chicken RPE possesses significantly higher specific retinol isomerohydrolase activity, when compared with RPE65 from rod-dominant species, [RefSeq, PubMed]; RPE65 undergoes conformational changes in secondary and tertiary structures upon binding with the phospholipid membrane. These conformational rearrangements facilitate restoration of a catalytically active state of RPE65., [RefSeq, PubMed]; Results provide conclusive evidence that RPE65 is the isomerohydrolase of the visual cycle., [RefSeq, PubMed]; Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.64;5.3.3.22", "go_molecular_function": "GO:0046872 metal ion binding;GO:0031210 phosphatidylcholine binding;GO:0001786 phosphatidylserine binding;GO:0016853 isomerase activity;GO:0052884 all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0007601 visual perception;GO:1901827 zeaxanthin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9YGX2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YH58-1", "uniprot_id": "FTCD_CHICK", "mass": 59154.0, "length": 541, "protein_name": "Formimidoyltransferase-cyclodeaminase", "gene_name": "FTCD", "organism": "Chicken", "refseq_name": "formimidoyltransferase-cyclodeaminase", "refseq_ac": "NP_990234", "gene_names_uniprotkb": "FTCD", "gene_names_refseq": "FTCD; formimidoyltransferase-cyclodeaminase", "protein_names_uniprotkb": "Formimidoyltransferase-cyclodeaminase; FTCD; Formiminotetrahydrofolate cyclodeaminase; Formiminotransferase-cyclodeaminase; Glutamate formiminotransferase; Glutamate formyltransferase; p60", "protein_names_refseq": "formimidoyltransferase-cyclodeaminase; formiminotransferase-cyclodeaminase; p60", "tax_id": 9031, "disease": "", "pathway": " (gga:395726)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9677386", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ224473.1, SRR12888532.203750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03376184 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ224473.1., [RefSeq]; Binds and promotes bundling of vimentin filaments originating from the Golgi., [UniProtKB, UniProtKB]; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.2.5;4.3.1.4", "go_molecular_function": "GO:0005542 folic acid binding;GO:0030409 glutamate formimidoyltransferase activity;GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005814 centriole", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9YH58-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9YH85-1", "uniprot_id": "TECTA_CHICK", "mass": 233965.0, "length": 2120, "protein_name": "Alpha-tectorin", "gene_name": "TECTA", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TECTA", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-tectorin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10320099;1490898;9079715", "class_list": "", "function": "One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals., [UniProtKB, PubMed]", "predicted_glycosites": 29, "predicted_n_glycosites": 28, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 29, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0098552 side of membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9YH85-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1Y3-1", "uniprot_id": "A0A8V0Y1Y3_CHICK", "mass": 54330.0, "length": 493, "protein_name": "Ciliary neurotrophic factor receptor subunit alpha", "gene_name": "CNTFR", "organism": "Chicken", "refseq_name": "ciliary neurotrophic factor receptor subunit alpha isoform X1", "refseq_ac": "XP_015132729", "gene_names_uniprotkb": "CNTFR", "gene_names_refseq": "CNTFR", "protein_names_uniprotkb": "Ciliary neurotrophic factor receptor subunit alpha", "protein_names_refseq": "ciliary neurotrophic factor receptor subunit alpha isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6788467)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 1, 2022 this sequence version replaced XP_015132729.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004897 ciliary neurotrophic factor receptor activity;GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding;GO:0005125 cytokine activity;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane;GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZV1-1", "uniprot_id": "A0A8V0XZV1_CHICK", "mass": 30891.0, "length": 272, "protein_name": "Transmembrane protein 192", "gene_name": "TMEM192", "organism": "Chicken", "refseq_name": "transmembrane protein 192 isoform X1", "refseq_ac": "XP_015140799", "gene_names_uniprotkb": "TMEM192", "gene_names_refseq": "TMEM192", "protein_names_uniprotkb": "Transmembrane protein 192", "protein_names_refseq": "transmembrane protein 192 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:107053202)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane;GO:0005770 late endosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZV1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y061-1", "uniprot_id": "A0A8V0Y061_CHICK", "mass": 75617.0, "length": 686, "protein_name": "Adhesion G protein-coupled receptor F4", "gene_name": "ADGRF4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADGRF4", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:107053171)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, 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"protein_names_uniprotkb": "ERCC excision repair 6 like 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZD2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYR8-1", "uniprot_id": "A0A8V0XYR8_CHICK", "mass": 107119.0, "length": 978, "protein_name": "DNA damage induced apoptosis suppressor", "gene_name": "DDIAS", "organism": "Chicken", "refseq_name": "DNA damage-induced apoptosis suppressor protein isoform X1", "refseq_ac": "XP_004938944", "gene_names_uniprotkb": "DDIAS", "gene_names_refseq": "DDIAS", "protein_names_uniprotkb": "DNA damage induced apoptosis suppressor", "protein_names_refseq": "DNA damage-induced apoptosis suppressor protein isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:101750305)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004938944.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYR8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XY00-1", "uniprot_id": "A0A8V0XY00_CHICK", "mass": 40606.0, "length": 362, "protein_name": "NOP2/Sun RNA methyltransferase 3", "gene_name": "NSUN3", "organism": "Chicken", "refseq_name": "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X1", "refseq_ac": "XP_416643", "gene_names_uniprotkb": "NSUN3", "gene_names_refseq": "NSUN3", "protein_names_uniprotkb": "NOP2/Sun RNA methyltransferase 3", "protein_names_refseq": "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_416643.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008173 RNA methyltransferase activity;GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006396 RNA processing;GO:0001510 RNA methylation;GO:0031167 rRNA methylation;GO:0070129 regulation of mitochondrial translation;GO:0002127 tRNA wobble base cytosine methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XY00-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYF4-1", "uniprot_id": "A0A8V0XYF4_CHICK", "mass": 40737.0, "length": 357, "protein_name": "Muscle-restricted coiled-coil protein", "gene_name": "MURC", "organism": "Chicken", "refseq_name": "caveolae-associated protein 4", "refseq_ac": "XP_040521757", "gene_names_uniprotkb": "MURC", "gene_names_refseq": "MURC", "protein_names_uniprotkb": "Muscle-restricted coiled-coil protein", "protein_names_refseq": "caveolae-associated protein 4", "tax_id": 9031, "disease": "", "pathway": " (gga:420986)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0030017 sarcomere;GO:0005901 caveola;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYF4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYH6-1", "uniprot_id": "A0A8V0XYH6_CHICK", "mass": 74472.0, "length": 686, "protein_name": "Phosphatidylinositol-binding clathrin assembly protein", "gene_name": "PICALM", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PICALM", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol-binding clathrin assembly protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-432722); (R-GGA-8856825); (R-GGA-8856828); (R-GGA-9696264)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005545 1-phosphatidylinositol binding;GO:0030276 clathrin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0048156 tau protein binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle;GO:0005634 nucleus;GO:0005769 early endosome", "go_biological_process": "GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0046579 positive regulation of Ras protein signal transduction;GO:0097753 membrane bending;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYH6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XWP5-1", "uniprot_id": "A0A8V0XWP5_CHICK", "mass": 41985.0, "length": 395, "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "MPV17", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MPV17", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial inner membrane protein Mpv17; Protein Mpv17", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9033241)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XWP5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XWR3-1", "uniprot_id": "A0A8V0XWR3_CHICK", "mass": 49941.0, "length": 447, "protein_name": "vesicle-fusing ATPase", "gene_name": "VPS4A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "VPS4A", "gene_names_refseq": "", "protein_names_uniprotkb": "vesicle-fusing ATPase; 3.6.4.6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-917729); (R-GGA-9668328)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;5.6.1.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0140545 ATP-dependent protein disaggregase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:0061738 late endosomal microautophagy;GO:1903774 positive regulation of viral budding via host ESCRT complex;GO:0032367 intracellular cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XWR3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XWV7-1", "uniprot_id": "A0A8V0XWV7_CHICK", "mass": 73266.0, "length": 658, "protein_name": "ribonuclease H", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "ribonuclease H; 3.1.26.4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003964 RNA-directed DNA polymerase activity;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XWV7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYX4-1", "uniprot_id": "A0A8V0XYX4_CHICK", "mass": 39945.0, "length": 369, "protein_name": "Dual specificity protein phosphatase", "gene_name": "DUSP1", "organism": "Chicken", "refseq_name": "dual specificity protein phosphatase 1", "refseq_ac": "NP_001078828", "gene_names_uniprotkb": "DUSP1", "gene_names_refseq": "DUSP1", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:374192); (R-GGA-112409); (R-GGA-5675221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01012004.1, HAEK01084938.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992484, SAMEA103992604 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1. On Sep 23, 2021 this sequence version replaced NP_001078828.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.67;3.1.3.27;2.7.11.24;3.1.3.21;3.1.3.74;3.1.3.53;3.1.3.18;3.1.3.2", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0051019 mitogen-activated protein kinase binding;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043409 negative regulation of MAPK cascade;GO:1990869 cellular response to chemokine;GO:0090027 negative regulation of monocyte chemotaxis;GO:0007162 negative regulation of cell adhesion;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYX4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XX07-1", "uniprot_id": "A0A8V0XX07_CHICK", "mass": 46341.0, "length": 440, "protein_name": "hypoxia-inducible factor-proline dioxygenase", "gene_name": "EGLN1", "organism": "Chicken", "refseq_name": "egl nine homolog 1", "refseq_ac": "XP_015139879", "gene_names_uniprotkb": "EGLN1", "gene_names_refseq": "EGLN1", "protein_names_uniprotkb": "hypoxia-inducible factor-proline dioxygenase; 1.14.11.29", "protein_names_refseq": "egl nine homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:768374); (R-GGA-1234176)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015139879.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.11.29;2.3.2.23", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0031545 peptidyl-proline 4-dioxygenase activity;GO:0160082 hypoxia-inducible factor-proline dioxygenase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0071456 cellular response to hypoxia;GO:0045765 regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XX07-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XX13-1", "uniprot_id": "A0A8V0XX13_CHICK", "mass": 187405.0, "length": 1719, "protein_name": "ATP-dependent DNA helicase Q4", "gene_name": "LOC101748706", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC101748706", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent DNA helicase Q4; 5.6.2.4; DNA 3'-5' helicase RecQ4; DNA helicase, RecQ-like type 4; RecQ protein-like 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0032357 oxidized purine DNA binding;GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0061820 telomeric D-loop disassembly;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XX13-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XX15-1", "uniprot_id": "A0A8V0XX15_CHICK", "mass": 177136.0, "length": 1555, "protein_name": "RNA uridylyltransferase", "gene_name": "ZCCHC6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ZCCHC6", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA uridylyltransferase; 2.7.7.52", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.52", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035198 miRNA binding;GO:0050265 RNA uridylyltransferase activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0010586 miRNA metabolic process;GO:0031054 pre-miRNA processing;GO:0031123 RNA 3'-end processing;GO:0141008 transposable element silencing by mRNA destabilization;GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XX15-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1L6-1", "uniprot_id": "A0A8V0Y1L6_CHICK", "mass": 26996.0, "length": 244, "protein_name": "Thiamine pyrophosphokinase", "gene_name": "TPK1", "organism": "Chicken", "refseq_name": "thiamin pyrophosphokinase 1 isoform X7", "refseq_ac": "XP_015131384", "gene_names_uniprotkb": "TPK1", "gene_names_refseq": "TPK1", "protein_names_uniprotkb": "Thiamine pyrophosphokinase; 2.7.6.2", "protein_names_refseq": "thiamin pyrophosphokinase 1 isoform X7", "tax_id": 9031, "disease": "", "pathway": " (gga:420780); (R-GGA-196819)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015131384.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.6.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004788 thiamine diphosphokinase activity;GO:0030975 thiamine binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0006772 thiamine metabolic process;GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XX75-1", "uniprot_id": "A0A8V0XX75_CHICK", "mass": 51409.0, "length": 481, "protein_name": "Mothers against decapentaplegic homolog", "gene_name": "LOC121108244", "organism": "Chicken", "refseq_name": "mothers against decapentaplegic homolog 4-like", "refseq_ac": "XP_040511598", "gene_names_uniprotkb": "LOC121108244", "gene_names_refseq": "LOC121108244", "protein_names_uniprotkb": "Mothers against decapentaplegic homolog; MAD homolog; Mothers against DPP homolog; SMAD family member", "protein_names_refseq": "mothers against decapentaplegic homolog 4-like", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1181150); (R-GGA-1502540); (R-GGA-201451); (R-GGA-2173789); (R-GGA-2173795); (R-GGA-2173796); (R-GGA-5689880); (R-GGA-8941326); (R-GGA-8941855); (R-GGA-9617828)", "pathway_count": 10, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XX75-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ56-1", "uniprot_id": "A0A8V0XZ56_CHICK", "mass": 147634.0, "length": 1327, "protein_name": "Contactin associated protein 2", "gene_name": "CNTNAP2", "organism": "Chicken", "refseq_name": "contactin-associated protein-like 2 isoform X1", "refseq_ac": "XP_025003363", "gene_names_uniprotkb": "CNTNAP2", "gene_names_refseq": "CNTNAP2", "protein_names_uniprotkb": "Contactin associated protein 2", "protein_names_refseq": "contactin-associated protein-like 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:768456)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_025003363.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0007612 learning;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ56-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XX88-1", "uniprot_id": "A0A8V0XX88_CHICK", "mass": 128741.0, "length": 1137, "protein_name": "Trafficking protein particle complex subunit 11", "gene_name": "TRAPPC11", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TRAPPC11", "gene_names_refseq": "", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 11", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030008 TRAPP complex", "go_biological_process": "GO:0045054 constitutive secretory pathway;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0061635 regulation of protein complex stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XX88-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXB7-1", "uniprot_id": "A0A8V0XXB7_CHICK", "mass": 25146.0, "length": 237, "protein_name": "3-ketoacyl-[acyl-carrier-protein] reductase beta subunit", "gene_name": "CBR4", "organism": "Chicken", "refseq_name": "3-oxoacyl-[acyl-carrier-protein] reductase isoform X1", "refseq_ac": "XP_004940989", "gene_names_uniprotkb": "CBR4", "gene_names_refseq": "CBR4", "protein_names_uniprotkb": "3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; Quinone reductase CBR4", "protein_names_refseq": "3-oxoacyl-[acyl-carrier-protein] reductase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422435); (R-GGA-75105)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004940989.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0048038 quinone binding;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0070402 NADPH binding;GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:1990204 oxidoreductase complex", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0051289 protein homotetramerization;GO:0051290 protein heterotetramerization;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXB7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXB8-1", "uniprot_id": "A0A8V0XXB8_CHICK", "mass": 65606.0, "length": 588, "protein_name": "Mitogen-activated protein kinase 15", "gene_name": "MAPK15", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MAPK15", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 15; 2.7.11.24", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005911 cell-cell junction;GO:0005776 autophagosome", "go_biological_process": "GO:1905832 positive regulation of spindle assembly;GO:0008284 positive regulation of cell population proliferation;GO:0010506 regulation of autophagy;GO:0035556 intracellular signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXC1-1", "uniprot_id": "A0A8V0XXC1_CHICK", "mass": 47119.0, "length": 425, "protein_name": "Queuine tRNA-ribosyltransferase accessory subunit 2", "gene_name": "QTRT2", "organism": "Chicken", "refseq_name": "queuine tRNA-ribosyltransferase accessory subunit 2", "refseq_ac": "NP_001025952", "gene_names_uniprotkb": "QTRT2", "gene_names_refseq": "QTRT2", "protein_names_uniprotkb": "Queuine tRNA-ribosyltransferase accessory subunit 2; Queuine tRNA-ribosyltransferase domain-containing protein 1", "protein_names_refseq": "queuine tRNA-ribosyltransferase accessory subunit 2; queuine tRNA-ribosyltransferase domain containing 1; queuine tRNA-ribosyltransferase subunit QTRTD1", "tax_id": 9031, "disease": "", "pathway": " (gga:418351)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719488.1, SRR13267653.12184.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000017.1. On Sep 23, 2021 this sequence version replaced NP_001025952.1., [RefSeq]; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0032473 cytoplasmic side of mitochondrial outer membrane;GO:0120507 tRNA-guanine transglycosylase complex", "go_biological_process": "GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXC1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXE8-1", "uniprot_id": "A0A8V0XXE8_CHICK", "mass": 33263.0, "length": 302, "protein_name": "Receptor expression-enhancing protein", "gene_name": "REEP5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "REEP5", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor expression-enhancing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXE8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXF0-1", "uniprot_id": "A0A8V0XXF0_CHICK", "mass": 49184.0, "length": 432, "protein_name": "Magnesium transporter", "gene_name": "MRS2", "organism": "Chicken", "refseq_name": "magnesium transporter MRS2 homolog, mitochondrial isoform X1", "refseq_ac": "XP_418911", "gene_names_uniprotkb": "MRS2", "gene_names_refseq": "MRS2", "protein_names_uniprotkb": "Magnesium transporter", "protein_names_refseq": "magnesium transporter MRS2 homolog, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420820); (R-GGA-5223345)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_418911.2. COMPLETENESS: full length., [RefSeq]; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix and regulates magnesium metabolism. Also permeable to calcium, sodium and potassium ions. Required for normal expression of the mitochondrial respiratory complex I subunits. May play a role in maintaining the inner mitochondrial membrane potential., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045016 mitochondrial magnesium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXF0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1V4-1", "uniprot_id": "A0A8V0Y1V4_CHICK", "mass": 47003.0, "length": 422, "protein_name": "Platelet-activating factor acetylhydrolase", "gene_name": "PLA2G7", "organism": "Chicken", "refseq_name": "platelet-activating factor acetylhydrolase precursor", "refseq_ac": "NP_990300", "gene_names_uniprotkb": "PLA2G7", "gene_names_refseq": "PLA2G7", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase; 3.1.1.47", "protein_names_refseq": "1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; LDL-PLA(2); LDL-associated phospholipase A2; PAF 2-acylhydrolase; PAF acetylhydrolase; phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma); platelet-activating factor acetylhydrolase precursor; platelet-activating factor acetylhydrolase", "tax_id": 9031, "disease": "", "pathway": " (gga:395816); (R-GGA-422085)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U34278.1, SRR13267654.62856.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000070.1. On Sep 23, 2021 this sequence version replaced NP_990300.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.47;3.5.1.1;3.1.1.5", "go_molecular_function": "GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0005543 phospholipid binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0034364 high-density lipoprotein particle;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0034440 lipid oxidation;GO:0034441 plasma lipoprotein particle oxidation;GO:0090026 positive regulation of monocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1V4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXK7-1", "uniprot_id": "A0A8V0XXK7_CHICK", "mass": 9535.0, "length": 82, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXK7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXN4-1", "uniprot_id": "A0A8V0XXN4_CHICK", "mass": 35723.0, "length": 331, "protein_name": "Paired box protein Pax-6", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Paired box protein Pax-6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0007420 brain development;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXN4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXN7-1", "uniprot_id": "A0A8V0XXN7_CHICK", "mass": 46745.0, "length": 441, "protein_name": "B9 domain-containing protein 2", "gene_name": "B9D2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "B9D2", "gene_names_refseq": "", "protein_names_uniprotkb": "B9 domain-containing protein 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes., [UniProtKB, UniProtKB, UniProtKB]; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005929 cilium;GO:0005615 extracellular space", "go_biological_process": "GO:0030030 cell projection organization;GO:0051781 positive regulation of cell division;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXN7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZR2-1", "uniprot_id": "A0A8V0XZR2_CHICK", "mass": 72436.0, "length": 662, "protein_name": "Tumor necrosis factor receptor superfamily member 21", "gene_name": "TNFRSF21", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TNFRSF21", "gene_names_refseq": "", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 21; Death receptor 6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422062)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0002250 adaptive immune response;GO:0032693 negative regulation of interleukin-10 production;GO:0032714 negative regulation of interleukin-5 production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0I6-1", "uniprot_id": "A0A8V0Y0I6_CHICK", "mass": 78454.0, "length": 706, "protein_name": "Spire type actin nucleation factor 2", "gene_name": "SPIRE2", "organism": "Chicken", "refseq_name": "protein spire homolog 2 isoform X1", "refseq_ac": "XP_414215", "gene_names_uniprotkb": "SPIRE2", "gene_names_refseq": "SPIRE2", "protein_names_uniprotkb": "Spire type actin nucleation factor 2", "protein_names_refseq": "protein spire homolog 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_414215.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005938 cell cortex;GO:0032154 cleavage furrow", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0045010 actin nucleation;GO:0051639 actin filament network formation;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0I6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXX0-1", "uniprot_id": "A0A8V0XXX0_CHICK", "mass": 33697.0, "length": 294, "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "RPS3A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RPS3A", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein eS1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006412 translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXX0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXX3-1", "uniprot_id": "A0A8V0XXX3_CHICK", "mass": 116351.0, "length": 1099, "protein_name": "Zinc finger protein ZFPM1", "gene_name": "ZFPM1", "organism": "Chicken", "refseq_name": "zinc finger protein ZFPM1 isoform X2", "refseq_ac": "XP_004944345", "gene_names_uniprotkb": "ZFPM1", "gene_names_refseq": "ZFPM1", "protein_names_uniprotkb": "Zinc finger protein ZFPM1; Friend of GATA protein 1", "protein_names_refseq": "zinc finger protein ZFPM1 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:415835); (R-GGA-8936459); (R-GGA-983231)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004944345.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0003192 mitral valve formation;GO:0003195 tricuspid valve formation;GO:0010724 regulation of definitive erythrocyte differentiation;GO:0035162 embryonic hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXX3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXZ0-1", "uniprot_id": "A0A8V0XXZ0_CHICK", "mass": 22364.0, "length": 200, "protein_name": "Receptor activity-modifying protein 3", "gene_name": "RAMP3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RAMP3", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor activity-modifying protein 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-418555); (R-GGA-419812)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015026 coreceptor activity;GO:0001605 adrenomedullin receptor activity;GO:0097643 amylin receptor activity;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0009986 cell surface;GO:0043235 receptor complex;GO:0005764 lysosome;GO:0150058 amylin receptor complex 3;GO:1903143 adrenomedullin receptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXZ0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XXZ6-1", "uniprot_id": "A0A8V0XXZ6_CHICK", "mass": 54094.0, "length": 487, "protein_name": "Mitochondrial-processing peptidase subunit beta", "gene_name": "PMPCB", "organism": "Chicken", "refseq_name": "mitochondrial-processing peptidase subunit beta isoform X1", "refseq_ac": "XP_015131213", "gene_names_uniprotkb": "PMPCB", "gene_names_refseq": "PMPCB", "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit beta; 3.4.24.64; Beta-MPP", "protein_names_refseq": "mitochondrial-processing peptidase subunit beta isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8949664)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015131213.1. COMPLETENESS: full length., [RefSeq]; Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.24.64", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0017087 mitochondrial processing peptidase complex;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006627 protein processing involved in protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XXZ6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XY06-1", "uniprot_id": "A0A8V0XY06_CHICK", "mass": 76102.0, "length": 705, "protein_name": "ATP-binding cassette sub-family B member 10, mitochondrial", "gene_name": "ABCB10", "organism": "Chicken", "refseq_name": "ATP-binding cassette sub-family B member 10, mitochondrial isoform X1", "refseq_ac": "XP_015139875", "gene_names_uniprotkb": "ABCB10", "gene_names_refseq": "ABCB10", "protein_names_uniprotkb": "ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ATP-binding cassette transporter 10", "protein_names_refseq": "ATP-binding cassette sub-family B member 10, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:421537)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0015421 ABC-type oligopeptide transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045648 positive regulation of erythrocyte differentiation;GO:0046985 positive regulation of hemoglobin biosynthetic process;GO:0048821 erythrocyte development;GO:0006783 heme biosynthetic process;GO:0090374 oligopeptide export from mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XY06-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XY92-1", "uniprot_id": "A0A8V0XY92_CHICK", "mass": 145658.0, "length": 1261, "protein_name": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4", "gene_name": "SMARCA4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SMARCA4", "gene_names_refseq": "", "protein_names_uniprotkb": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1266695); (R-GGA-201722); (R-GGA-3214858); (R-GGA-3247509); (R-GGA-8939243); (R-GGA-9764725); (R-GGA-9933937); (R-GGA-9933939); (R-GGA-9933946); (R-GGA-9933947); (R-GGA-9934037)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0001650 fibrillar center", "go_biological_process": "GO:1902661 positive regulation of glucose mediated signaling pathway;GO:0003407 neural retina development;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XY92-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y074-1", "uniprot_id": "A0A8V0Y074_CHICK", "mass": 140006.0, "length": 1233, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "NEK1", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase Nek1 isoform X1", "refseq_ac": "XP_040555476", "gene_names_uniprotkb": "NEK1", "gene_names_refseq": "NEK1", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase Nek1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9861718)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0034451 centriolar satellite;GO:0000242 pericentriolar material", "go_biological_process": "GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y074-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYM3-1", "uniprot_id": "A0A8V0XYM3_CHICK", "mass": 41954.0, "length": 404, "protein_name": "POU domain protein", "gene_name": "POU4F2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "POU4F2", "gene_names_refseq": "", "protein_names_uniprotkb": "POU domain protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0002039 p53 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex;GO:0000791 euchromatin", "go_biological_process": "GO:1902870 negative regulation of amacrine cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYM3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYR2-1", "uniprot_id": "A0A8V0XYR2_CHICK", "mass": 30650.0, "length": 279, "protein_name": "Endothelin-1", "gene_name": "EDN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EDN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Endothelin-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0019229 regulation of vasoconstriction;GO:0042310 vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYR2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYV8-1", "uniprot_id": "A0A8V0XYV8_CHICK", "mass": 105081.0, "length": 920, "protein_name": "HECT domain-containing protein", "gene_name": "LOC422513", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC422513", "gene_names_refseq": "", "protein_names_uniprotkb": "HECT domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYV8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XYX6-1", "uniprot_id": "A0A8V0XYX6_CHICK", "mass": 17983.0, "length": 164, "protein_name": "Glycine cleavage system H protein", "gene_name": "GCSH", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GCSH", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycine cleavage system H protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6783984); (R-GGA-9857492)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The H protein shuttles the methylamine group of glycine from the P protein to the T protein., [UniProtKB, UniProtKB]; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0019464 glycine decarboxylation via glycine cleavage system", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XYX6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ01-1", "uniprot_id": "A0A8V0XZ01_CHICK", "mass": 36733.0, "length": 341, "protein_name": "Protein YIF1", "gene_name": "YIF1B", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "YIF1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein YIF1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has a role in transport between endoplasmic reticulum and Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ01-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ10-1", "uniprot_id": "A0A8V0XZ10_CHICK", "mass": 83138.0, "length": 753, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "PJA2", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase Praja-2 isoform X1", "refseq_ac": "XP_046761729", "gene_names_uniprotkb": "PJA2", "gene_names_refseq": "PJA2", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase Praja-2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:415612)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ10-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ26-1", "uniprot_id": "A0A8V0XZ26_CHICK", "mass": 80142.0, "length": 718, "protein_name": "Telomeric repeat-binding factor 2", "gene_name": "TERF2", "organism": "Chicken", "refseq_name": "telomeric repeat-binding factor 2", "refseq_ac": "NP_001258821", "gene_names_uniprotkb": "TERF2", "gene_names_refseq": "TERF2; TRF2", "protein_names_uniprotkb": "Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein", "protein_names_refseq": "TTAGGG-repeat binding factor 2 TRF2; telomeric DNA-binding protein; telomeric repeat binding factor a; telomeric repeat-binding factor 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395598); (R-GGA-171319); (R-GGA-174411); (R-GGA-174414); (R-GGA-174417); (R-GGA-174430); (R-GGA-174437)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ133783.1, SRR13267658.3006.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Sep 23, 2021 this sequence version replaced NP_001258821.1. Sequence Note: This RefSeq record was created from transcripts of different breeds and genomic sequence data because no single transcript from the same breed was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0042803 protein homodimerization activity;GO:0003691 double-stranded telomeric DNA binding;GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0070187 shelterin complex;GO:0005634 nucleus;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006278 RNA-templated DNA biosynthetic process;GO:0031848 protection from non-homologous end joining at telomere;GO:0070198 protein localization to chromosome, telomeric region;GO:0061820 telomeric D-loop disassembly;GO:0032210 regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ26-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZ65-1", "uniprot_id": "A0A8V0XZ65_CHICK", "mass": 34696.0, "length": 301, "protein_name": "CD2 molecule", "gene_name": "CD2", "organism": "Chicken", "refseq_name": "T-cell surface antigen CD2 isoform X1", "refseq_ac": "XP_015153687", "gene_names_uniprotkb": "CD2", "gene_names_refseq": "CD2", "protein_names_uniprotkb": "CD2 molecule", "protein_names_refseq": "T-cell surface antigen CD2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:768858); (R-GGA-202733)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015153687.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0098609 cell-cell adhesion;GO:0030101 natural killer cell activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZ65-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y131-1", "uniprot_id": "A0A8V0Y131_CHICK", "mass": 68619.0, "length": 617, "protein_name": "Electron transfer flavoprotein-ubiquinone oxidoreductase", "gene_name": "ETFDH", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ETFDH", "gene_names_refseq": "", "protein_names_uniprotkb": "Electron transfer flavoprotein-ubiquinone oxidoreductase; 1.5.5.1; ETF-QO", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts electrons from ETF and reduces ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.5.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004174 electron-transferring-flavoprotein dehydrogenase activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZA7-1", "uniprot_id": "A0A8V0XZA7_CHICK", "mass": 90496.0, "length": 795, "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "gene_name": "PPARGC1A", "organism": "Chicken", "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "refseq_ac": "NP_001006457", "gene_names_uniprotkb": "PPARGC1A", "gene_names_refseq": "AVPGC-1ALPHA; PPARGC1A", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "protein_names_refseq": "peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome-proliferator-activated receptor-gamma co-activator-1", "tax_id": 9031, "disease": "", "pathway": " (gga:422815); (R-GGA-9841922)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "24615053;26400301;28439972;33624372", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.1745.1, AB170013.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1. On Sep 23, 2021 this sequence version replaced NP_001006457.1., [RefSeq]; Effects of dried natto diet on the transcript levels of the peroxisome proliferator-activated receptor-gamma, coactivator-1alpha and -1beta, and nuclear receptor corepressor 1 genes in laying hens., [RefSeq, PubMed]; The quantitative trait meat production loci in chickens were mapped to PPARGC1A and SLIT2. Publication Status: Online-Only, [RefSeq, PubMed]; These findings indicate that mitochondrial biogenesis and PGC-1alpha mRNA gene expression differ between male broiler chickens from ascites resistant and susceptible lines in a tissue-specific manner., [RefSeq, PubMed]; We concluded that polymorphisms of the PGC-1alpha gene and their haplotypes are associated with chicken skeletal myofiber type traits Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0003712 transcription coregulator activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0016605 PML body;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006094 gluconeogenesis;GO:0032502 developmental process;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8V0XZA7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZB8-1", "uniprot_id": "A0A8V0XZB8_CHICK", "mass": 123656.0, "length": 1099, "protein_name": "RNA helicase", "gene_name": "DHX34", "organism": "Chicken", "refseq_name": "probable ATP-dependent RNA helicase DHX34 isoform X1", "refseq_ac": "XP_040511037", "gene_names_uniprotkb": "DHX34", "gene_names_refseq": "DHX34", "protein_names_uniprotkb": "RNA helicase; 3.6.4.13", "protein_names_refseq": "probable ATP-dependent RNA helicase DHX34 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052569.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0004386 helicase activity", "go_cellular_component": "", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042327 positive regulation of phosphorylation;GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZB8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZG8-1", "uniprot_id": "A0A8V0XZG8_CHICK", "mass": 42722.0, "length": 381, "protein_name": "Hyaluronan binding protein 4", "gene_name": "HABP4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HABP4", "gene_names_refseq": "", "protein_names_uniprotkb": "Hyaluronan binding protein 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-114608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0030578 PML body organization;GO:0033120 positive regulation of RNA splicing;GO:0045948 positive regulation of translational initiation;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZG8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZI4-1", "uniprot_id": "A0A8V0XZI4_CHICK", "mass": 153306.0, "length": 1376, "protein_name": "Adhesion G protein-coupled receptor F5", "gene_name": "ADGRF5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADGRF5", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:101750527)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045177 apical part of cell;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZI4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZI9-1", "uniprot_id": "A0A8V0XZI9_CHICK", "mass": 30075.0, "length": 255, "protein_name": "Large ribosomal subunit protein bL19m", "gene_name": "MRPL19", "organism": "Chicken", "refseq_name": "39S ribosomal protein L19, mitochondrial isoform X1", "refseq_ac": "XP_420071", "gene_names_uniprotkb": "MRPL19", "gene_names_refseq": "MRPL19", "protein_names_uniprotkb": "Large ribosomal subunit protein bL19m; 39S ribosomal protein L19, mitochondrial", "protein_names_refseq": "39S ribosomal protein L19, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5389840); (R-GGA-5419276); (R-GGA-9937383)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_420071.5. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005634 nucleus", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZI9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZJ9-1", "uniprot_id": "A0A8V0XZJ9_CHICK", "mass": 18459.0, "length": 167, "protein_name": "LY6/PLAUR domain containing 2", "gene_name": "LYPD2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LYPD2", "gene_names_refseq": "", "protein_names_uniprotkb": "LY6/PLAUR domain containing 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:768929)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0030154 cell differentiation;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZJ9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZS8-1", "uniprot_id": "A0A8V0XZS8_CHICK", "mass": 65055.0, "length": 598, "protein_name": "RBR-type E3 ubiquitin transferase", "gene_name": "RNF19AL", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RNF19AL", "gene_names_refseq": "", "protein_names_uniprotkb": "RBR-type E3 ubiquitin transferase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZS8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZV2-1", "uniprot_id": "A0A8V0XZV2_CHICK", "mass": 167545.0, "length": 1495, "protein_name": "Rho GTPase-activating protein 35", "gene_name": "ARHGAP35", "organism": "Chicken", "refseq_name": "rho GTPase-activating protein 35 isoform X1", "refseq_ac": "XP_025000235", "gene_names_uniprotkb": "ARHGAP35", "gene_names_refseq": "ARHGAP35", "protein_names_uniprotkb": "Rho GTPase-activating protein 35", "protein_names_refseq": "rho GTPase-activating protein 35 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:425730); (R-GGA-416550); (R-GGA-8849471); (R-GGA-8980692); (R-GGA-9013026); (R-GGA-9013106); (R-GGA-9013148); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013406); (R-GGA-9013408); (R-GGA-9013409); (R-GGA-9013423); (R-GGA-9696264); (R-GGA-9696270)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052569.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_025000235.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0008289 lipid binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007165 signal transduction;GO:0050770 regulation of axonogenesis;GO:0008064 regulation of actin polymerization or depolymerization;GO:0010976 positive regulation of neuron projection development;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZV2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZX8-1", "uniprot_id": "A0A8V0XZX8_CHICK", "mass": 30015.0, "length": 262, "protein_name": "Transcription factor A, mitochondrial", "gene_name": "TFAM", "organism": "Chicken", "refseq_name": "transcription factor A, mitochondrial", "refseq_ac": "NP_989431", "gene_names_uniprotkb": "TFAM", "gene_names_refseq": "TFAM", "protein_names_uniprotkb": "Transcription factor A, mitochondrial", "protein_names_refseq": "transcription factor A, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:373888); (R-GGA-163282); (R-GGA-9837999)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "37742962", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB059657.1, AJ719978.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000227.1. On Sep 23, 2021 this sequence version replaced NP_989431.1., [RefSeq]; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA., [UniProtKB, UniProtKB, UniProtKB]; Mitochondrial DNA release mediated by TFAM deficiency promotes copper-induced mitochondrial innate immune response via cGAS-STING signalling in chicken hepatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0034246 mitochondrial transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006391 transcription initiation at mitochondrial promoter;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8V0XZX8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0XZZ5-1", "uniprot_id": "A0A8V0XZZ5_CHICK", "mass": 20117.0, "length": 177, "protein_name": "Insulin like growth factor 1", "gene_name": "IGF1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "IGF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin like growth factor 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-114608); (R-GGA-2404192); (R-GGA-2428928); (R-GGA-2428933); (R-GGA-381426); (R-GGA-422085)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005615 extracellular space;GO:0098794 postsynapse;GO:0042567 insulin-like growth factor ternary complex", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0014896 muscle hypertrophy;GO:0014904 myotube cell development;GO:0060283 negative regulation of oocyte development;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0XZZ5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y004-1", "uniprot_id": "A0A8V0Y004_CHICK", "mass": 25143.0, "length": 240, "protein_name": "Mediator of RNA polymerase II transcription subunit 29", "gene_name": "MED29", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MED29", "gene_names_refseq": "", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 29; Intersex-like protein; Mediator complex subunit 29", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y004-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y005-1", "uniprot_id": "A0A8V0Y005_CHICK", "mass": 74207.0, "length": 680, "protein_name": "Stress-70 protein, mitochondrial", "gene_name": "HSPA9", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSPA9", "gene_names_refseq": "", "protein_names_uniprotkb": "Stress-70 protein, mitochondrial; 3.6.4.10; 75 kDa glucose-regulated protein; Heat shock 70 kDa protein 9", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:416183); (R-GGA-6799198); (R-GGA-9837999); (R-GGA-9865881)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.4.1.3;3.6.4.6;3.4.21.53;1.2.4.1;3.6.4.13;7.1.1.2;3.6.1.5;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;5.6.1.6;1.3.8.1;1.3.8.5;2.3.1.9;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;5.3.3.21;4.98.1.1;4.2.1.2;4.2.99.18;2.7.11.1;7.2.2.-;2.3.3.10;2.7.1.23;1.16.3.1;5.3.3.8;3.6.5.-;1.2.4.2;3.5.3.1;3.6.4.-;2.8.1.7;3.1.-.-;7.1.1.8;5.6.2.-;6.4.1.3;2.3.1.-;2.7.7.7;2.7.7.49;7.1.2.2;1.2.1.3;2.3.2.27;1.1.1.37;2.7.11.-;3.1.3.1;3.6.1.15;3.6.1.-;6.1.1.5;5.6.1.7", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0030218 erythrocyte differentiation;GO:0042026 protein refolding;GO:0045647 negative regulation of erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y005-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y059-1", "uniprot_id": "A0A8V0Y059_CHICK", "mass": 16669.0, "length": 149, "protein_name": "Ubiquitin conjugating enzyme E2 D1", "gene_name": "UBE2D1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "UBE2D1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin conjugating enzyme E2 D1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1234176); (R-GGA-141430); (R-GGA-174048); (R-GGA-174084); (R-GGA-174154); (R-GGA-174178); (R-GGA-174184); (R-GGA-176407); (R-GGA-176408); (R-GGA-176409); (R-GGA-176412); (R-GGA-179409); (R-GGA-201451); (R-GGA-2173795); (R-GGA-2467813); (R-GGA-2559582); (R-GGA-5357905); (R-GGA-5689896); (R-GGA-68867); (R-GGA-69017); (R-GGA-8866652); (R-GGA-8866654); (R-GGA-8951664); (R-GGA-9033241); (R-GGA-937041); (R-GGA-983168); (R-GGA-9954709); (R-GGA-9954716)", "pathway_count": 28, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.23;2.3.2.27;2.1.1.367;2.3.2.26;3.4.19.12;6.2.1.45;2.3.2.24;1.14.11.29;2.3.2.31;2.7.11.1;6.2.1.64;3.4.22.61;2.7.11.22;2.7.11.21;4.2.99.18;2.3.2.34", "go_molecular_function": "GO:0005524 ATP binding;GO:0016740 transferase activity;GO:0061630 ubiquitin protein ligase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031398 positive regulation of protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y059-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y044-1", "uniprot_id": "A0A8V0Y044_CHICK", "mass": 21640.0, "length": 193, "protein_name": "Securin", "gene_name": "PTTG2", "organism": "Chicken", "refseq_name": "securin isoform 1", "refseq_ac": "NP_001264669", "gene_names_uniprotkb": "PTTG2", "gene_names_refseq": "PTTG1; PTTG2", "protein_names_uniprotkb": "Securin", "protein_names_refseq": "pituitary tumor-transforming 1; pituitary tumor-transforming protein 1; securin isoform 1", "tax_id": 9031, "disease": "", "pathway": " (gga:416158); (R-GGA-174154); (R-GGA-174178); (R-GGA-2467813)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ441614.1, HAEL01000099.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000256.1. On Sep 23, 2021 this sequence version replaced NP_001264669.1. Transcript Variant: This variant (1) encodes the longer isoform (1)., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005930 axoneme", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0051301 cell division;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y044-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y048-1", "uniprot_id": "A0A8V0Y048_CHICK", "mass": 34032.0, "length": 306, "protein_name": "CD200 receptor 1A", "gene_name": "CD200R1A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CD200R1A", "gene_names_refseq": "", "protein_names_uniprotkb": "CD200 receptor 1A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-198933)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y048-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y062-1", "uniprot_id": "A0A8V0Y062_CHICK", "mass": 60444.0, "length": 556, "protein_name": "b(0,+)-type amino acid transporter 1", "gene_name": "LOC421965", "organism": "Chicken", "refseq_name": "b(0,+)-type amino acid transporter 1 isoform X4", "refseq_ac": "XP_419976", "gene_names_uniprotkb": "LOC421965", "gene_names_refseq": "LOC421965", "protein_names_uniprotkb": "b(0,+)-type amino acid transporter 1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9", "protein_names_refseq": "b(0,+)-type amino acid transporter 1 isoform X4", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_419976.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y062-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y075-1", "uniprot_id": "A0A8V0Y075_CHICK", "mass": 67291.0, "length": 580, "protein_name": "Pre-mRNA-splicing factor SLU7", "gene_name": "SLU7", "organism": "Chicken", "refseq_name": "pre-mRNA-splicing factor SLU7 isoform X1", "refseq_ac": "XP_040502813", "gene_names_uniprotkb": "SLU7", "gene_names_refseq": "SLU7", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SLU7", "protein_names_refseq": "pre-mRNA-splicing factor SLU7 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:416157)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Involved in pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030628 pre-mRNA 3'-splice site binding;GO:0008270 zinc ion binding;GO:0000386 second spliceosomal transesterification activity", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome;GO:0030532 small nuclear ribonucleoprotein complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006886 intracellular protein transport;GO:0034605 cellular response to heat;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y075-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y068-1", "uniprot_id": "A0A8V0Y068_CHICK", "mass": 165420.0, "length": 1505, "protein_name": "Zinc finger FYVE domain-containing protein", "gene_name": "ZFYVE16", "organism": "Chicken", "refseq_name": "zinc finger FYVE domain-containing protein 16 isoform X1", "refseq_ac": "XP_004949521", "gene_names_uniprotkb": "ZFYVE16", "gene_names_refseq": "ZFYVE16", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein", "protein_names_refseq": "zinc finger FYVE domain-containing protein 16 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427315); (R-GGA-201451)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004949521.1. COMPLETENESS: full length., [RefSeq]; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005545 1-phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0016197 endosomal transport;GO:0006622 protein targeting to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y068-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0B5-1", "uniprot_id": "A0A8V0Y0B5_CHICK", "mass": 112779.0, "length": 1010, "protein_name": "Glutamate receptor", "gene_name": "GRID1", "organism": "Chicken", "refseq_name": "glutamate receptor ionotropic, delta-1 isoform X3", "refseq_ac": "XP_426488", "gene_names_uniprotkb": "GRID1", "gene_names_refseq": "GRID1", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, delta-1 isoform X3", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052537.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_426488.1. COMPLETENESS: full length., [RefSeq]; Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity;GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane;GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane", "go_biological_process": "GO:0051963 regulation of synapse assembly;GO:0035249 synaptic transmission, glutamatergic;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0035176 social behavior;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0B5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0D1-1", "uniprot_id": "A0A8V0Y0D1_CHICK", "mass": 36730.0, "length": 339, "protein_name": "Fructose-1,6-bisphosphatase 1", "gene_name": "FBP1", "organism": "Chicken", "refseq_name": "fructose-1,6-bisphosphatase 1", "refseq_ac": "NP_001264977", "gene_names_uniprotkb": "FBP1", "gene_names_refseq": "FBP1", "protein_names_uniprotkb": "Fructose-1,6-bisphosphatase 1; 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase", "protein_names_refseq": "fructose-1,6-bisphosphatase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395218); (R-GGA-70263)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX950458.2, HAEL01000213.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000094.1. On May 4, 2013 this sequence version replaced XP_425040.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.11", "go_molecular_function": "GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016208 AMP binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0071466 cellular response to xenobiotic stimulus;GO:0006094 gluconeogenesis;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0F1-1", "uniprot_id": "A0A8V0Y0F1_CHICK", "mass": 58630.0, "length": 528, "protein_name": "Opsin 4", "gene_name": "OPN4", "organism": "Chicken", "refseq_name": "melanopsin isoform X1", "refseq_ac": "XP_046798747", "gene_names_uniprotkb": "OPN4", "gene_names_refseq": "MOP; OPN4-2; OPN4m; OPN4; cOpn4L; melanopsin; opsin-4", "protein_names_uniprotkb": "Opsin 4", "protein_names_refseq": "melanopsin isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-416476); (R-GGA-419771)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052537.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:1990913 sperm head plasma membrane", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0H7-1", "uniprot_id": "A0A8V0Y0H7_CHICK", "mass": 141774.0, "length": 1298, "protein_name": "Zinc finger protein 532", "gene_name": "ZNF532", "organism": "Chicken", "refseq_name": "zinc finger protein 532 isoform X1", "refseq_ac": "XP_003642945", "gene_names_uniprotkb": "ZNF532", "gene_names_refseq": "ZNF532", "protein_names_uniprotkb": "Zinc finger protein 532", "protein_names_refseq": "zinc finger protein 532 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:100857356); (R-GGA-9940951)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_003642945.1. COMPLETENESS: full length., [RefSeq]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0H8-1", "uniprot_id": "A0A8V0Y0H8_CHICK", "mass": 24715.0, "length": 220, "protein_name": "Claudin", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0H8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0I9-1", "uniprot_id": "A0A8V0Y0I9_CHICK", "mass": 24988.0, "length": 241, "protein_name": "Mitochondria localized glutamic acid rich protein", "gene_name": "MGARP", "organism": "Chicken", "refseq_name": "protein MGARP", "refseq_ac": "NP_001392825", "gene_names_uniprotkb": "MGARP", "gene_names_refseq": "MGARP", "protein_names_uniprotkb": "Mitochondria localized glutamic acid rich protein", "protein_names_refseq": "protein MGARP", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01032105.1, SRR13267662.54712.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000073.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0I9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0J2-1", "uniprot_id": "A0A8V0Y0J2_CHICK", "mass": 57316.0, "length": 503, "protein_name": "Clusterin", "gene_name": "CLU", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CLU", "gene_names_refseq": "", "protein_names_uniprotkb": "Clusterin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-114608); (R-GGA-166665); (R-GGA-977606)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0002434 immune complex clearance;GO:0001774 microglial cell activation;GO:0042127 regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0J2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0J7-1", "uniprot_id": "A0A8V0Y0J7_CHICK", "mass": 40446.0, "length": 371, "protein_name": "Solute carrier family 35 member F6", "gene_name": "SLC35F6", "organism": "Chicken", "refseq_name": "solute carrier family 35 member F6", "refseq_ac": "XP_040554023", "gene_names_uniprotkb": "SLC35F6", "gene_names_refseq": "SLC35F6", "protein_names_uniprotkb": "Solute carrier family 35 member F6", "protein_names_refseq": "solute carrier family 35 member F6", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May play a role as a nucleotide-sugar transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0V2-1", "uniprot_id": "A0A8V0Y0V2_CHICK", "mass": 59363.0, "length": 544, "protein_name": "High affinity choline transporter 1", "gene_name": "LOC428094", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC428094", "gene_names_refseq": "", "protein_names_uniprotkb": "High affinity choline transporter 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005307 choline:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0008292 acetylcholine biosynthetic process;GO:0015871 choline transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0X5-1", "uniprot_id": "A0A8V0Y0X5_CHICK", "mass": 114130.0, "length": 1051, "protein_name": "Protocadherin 10", "gene_name": "PCDH10", "organism": "Chicken", "refseq_name": "protocadherin-10 isoform X1", "refseq_ac": "XP_015140849", "gene_names_uniprotkb": "PCDH10", "gene_names_refseq": "OLpcad; PCDH10", "protein_names_uniprotkb": "Protocadherin 10", "protein_names_refseq": "protocadherin-10 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0X5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y0Y6-1", "uniprot_id": "A0A8V0Y0Y6_CHICK", "mass": 59457.0, "length": 553, "protein_name": "Solute carrier family 7 member 5", "gene_name": "SLC7A5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC7A5", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 7 member 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015196 L-tryptophan transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015349 thyroid hormone transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0031528 microvillus membrane;GO:1990184 amino acid transport complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0015824 proline transport;GO:0032328 alanine transport;GO:1904556 L-tryptophan transmembrane transport;GO:1903801 L-leucine import across plasma membrane;GO:0015804 neutral amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y0Y6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y103-1", "uniprot_id": "A0A8V0Y103_CHICK", "mass": 126624.0, "length": 1142, "protein_name": "Protocadherin 18", "gene_name": "PCDH18", "organism": "Chicken", "refseq_name": "protocadherin-18 isoform X1", "refseq_ac": "XP_004940992", "gene_names_uniprotkb": "PCDH18", "gene_names_refseq": "PCDH18", "protein_names_uniprotkb": "Protocadherin 18", "protein_names_refseq": "protocadherin-18 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422438)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Potential calcium-dependent cell-adhesion protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007420 brain development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y105-1", "uniprot_id": "A0A8V0Y105_CHICK", "mass": 24863.0, "length": 217, "protein_name": "Stathmin-4", "gene_name": "STMN4", "organism": "Chicken", "refseq_name": "stathmin-4 isoform X1", "refseq_ac": "XP_004935927", "gene_names_uniprotkb": "STMN4", "gene_names_refseq": "STMN4", "protein_names_uniprotkb": "Stathmin-4", "protein_names_refseq": "stathmin-4 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422010)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_004935927.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043005 neuron projection", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031175 neuron projection development;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y122-1", "uniprot_id": "A0A8V0Y122_CHICK", "mass": 43593.0, "length": 380, "protein_name": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3", "gene_name": "ST8SIA3", "organism": "Chicken", "refseq_name": "sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase", "refseq_ac": "NP_001001746", "gene_names_uniprotkb": "ST8SIA3", "gene_names_refseq": "SIAT8C; ST8SIA3Z; ST8SIA3", "protein_names_uniprotkb": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3", "protein_names_refseq": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3-Z; alpha-2,8-sialyltransferase 8C; sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:414796); (R-GGA-4085001); (R-GGA-975577)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01052838.1, HAEK01000199.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992528 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000086.1. On Nov 20, 2021 this sequence version replaced NP_001001746.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y127-1", "uniprot_id": "A0A8V0Y127_CHICK", "mass": 53266.0, "length": 467, "protein_name": "thiol oxidase", "gene_name": "ERO1B", "organism": "Chicken", "refseq_name": "ERO1-like protein beta isoform X1", "refseq_ac": "XP_419554", "gene_names_uniprotkb": "ERO1B", "gene_names_refseq": "ERO1B", "protein_names_uniprotkb": "thiol oxidase; 1.8.3.2", "protein_names_refseq": "ERO1-like protein beta isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-264876)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_419554.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.8.3.2;5.3.4.1", "go_molecular_function": "GO:0071949 FAD binding;GO:0015035 protein-disulfide reductase activity;GO:0016972 thiol oxidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0034975 protein folding in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y132-1", "uniprot_id": "A0A8V0Y132_CHICK", "mass": 206380.0, "length": 1885, "protein_name": "von Willebrand factor D and EGF domain-containing protein", "gene_name": "LOC424300", "organism": "Chicken", "refseq_name": "von Willebrand factor D and EGF domain-containing protein-like isoform X1", "refseq_ac": "XP_040559747", "gene_names_uniprotkb": "LOC424300", "gene_names_refseq": "LOC424300", "protein_names_uniprotkb": "von Willebrand factor D and EGF domain-containing protein", "protein_names_refseq": "von Willebrand factor D and EGF domain-containing protein-like isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:424300)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y132-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1A4-1", "uniprot_id": "A0A8V0Y1A4_CHICK", "mass": 100416.0, "length": 922, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 1", "gene_name": "ADAMTS1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADAMTS1", "gene_names_refseq": "", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5173214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0031410 cytoplasmic vesicle;GO:0005604 basement membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:1904754 positive regulation of vascular associated smooth muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1C2-1", "uniprot_id": "A0A8V0Y1C2_CHICK", "mass": 169857.0, "length": 1539, "protein_name": "ATP-binding cassette sub-family C member 10", "gene_name": "ABCC10", "organism": "Chicken", "refseq_name": "ATP-binding cassette sub-family C member 10 isoform X2", "refseq_ac": "XP_015139257", "gene_names_uniprotkb": "ABCC10", "gene_names_refseq": "ABCC10", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 10; 7.6.2.2; 7.6.2.3; Multidrug resistance-associated protein 7", "protein_names_refseq": "ATP-binding cassette sub-family C member 10 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-382556)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015139257.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6;7.6.2.2;7.6.2.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0055085 transmembrane transport;GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1C2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1C8-1", "uniprot_id": "A0A8V0Y1C8_CHICK", "mass": 53970.0, "length": 508, "protein_name": "Dihydrolipoyl dehydrogenase", "gene_name": "DLD", "organism": "Chicken", "refseq_name": "dihydrolipoyl dehydrogenase, mitochondrial", "refseq_ac": "NP_001025898", "gene_names_uniprotkb": "DLD", "gene_names_refseq": "DLD", "protein_names_uniprotkb": "Dihydrolipoyl dehydrogenase; 1.8.1.4", "protein_names_refseq": "dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); dihydrolipoyl dehydrogenase, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:417699); (R-GGA-204174); (R-GGA-5362517); (R-GGA-6783984); (R-GGA-70895); (R-GGA-9853506); (R-GGA-9858328); (R-GGA-9859138); (R-GGA-9861559)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01027574.1, HAEL01008218.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Sep 23, 2021 this sequence version replaced NP_001025898.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.2.4.1;1.2.4.4;3.1.3.43;2.7.11.-;2.3.1.61;2.3.1.-;1.8.1.4;1.2.4.2;2.3.1.12;3.1.3.16", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0031514 motile cilium;GO:0043159 acrosomal matrix;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA;GO:0019474 L-lysine catabolic process to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1D0-1", "uniprot_id": "A0A8V0Y1D0_CHICK", "mass": 110197.0, "length": 994, "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase", "gene_name": "CTDP1", "organism": "Chicken", "refseq_name": "RNA polymerase II subunit A C-terminal domain phosphatase", "refseq_ac": "XP_040519153", "gene_names_uniprotkb": "CTDP1", "gene_names_refseq": "CTDP1", "protein_names_uniprotkb": "RNA polymerase II subunit A C-terminal domain phosphatase; 3.1.3.16", "protein_names_refseq": "RNA polymerase II subunit A C-terminal domain phosphatase", "tax_id": 9031, "disease": "", "pathway": " (gga:420813); (R-GGA-112382); (R-GGA-674695); (R-GGA-6796648); (R-GGA-75955)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation., [UniProtKB, UniProtKB]; This promotes the activity of RNA polymerase II., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;2.7.11.22;2.7.11.23;2.7.11.24;3.1.3.67;3.1.3.27;3.1.3.74;2.7.7.6;5.6.2.4;3.1.3.53", "go_molecular_function": "GO:0030957 Tat protein binding;GO:0001096 TFIIF-class transcription factor complex binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0051233 spindle midzone;GO:0030496 midbody", "go_biological_process": "GO:0051301 cell division;GO:0010458 exit from mitosis;GO:0043923 host-mediated activation of viral transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1D0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1D6-1", "uniprot_id": "A0A8V0Y1D6_CHICK", "mass": 32598.0, "length": 308, "protein_name": "Vasodilator stimulated phosphoprotein", "gene_name": "VASP", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "VASP", "gene_names_refseq": "", "protein_names_uniprotkb": "Vasodilator stimulated phosphoprotein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-446353)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030027 lamellipodium", "go_biological_process": "GO:0008154 actin polymerization or depolymerization;GO:0001843 neural tube closure;GO:0030838 positive regulation of actin filament polymerization;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1D6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1J8-1", "uniprot_id": "A0A8V0Y1J8_CHICK", "mass": 160995.0, "length": 1439, "protein_name": "3'-5' RNA helicase YTHDC2", "gene_name": "YTHDC2", "organism": "Chicken", "refseq_name": "3'-5' RNA helicase YTHDC2 isoform X2", "refseq_ac": "XP_025000689", "gene_names_uniprotkb": "YTHDC2", "gene_names_refseq": "YTHDC2", "protein_names_uniprotkb": "3'-5' RNA helicase YTHDC2; 3.6.4.13", "protein_names_refseq": "3'-5' RNA helicase YTHDC2 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9930044)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;2.7.7.19;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0070063 RNA polymerase binding;GO:0004386 helicase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0044829 host-mediated activation of viral genome replication;GO:0034612 response to tumor necrosis factor;GO:0007286 spermatid development;GO:0070555 response to interleukin-1;GO:0048599 oocyte development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1J8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1L5-1", "uniprot_id": "A0A8V0Y1L5_CHICK", "mass": 62805.0, "length": 552, "protein_name": "Sulfotransferase", "gene_name": "CHST6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CHST6", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase; 2.8.2.-", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:770257); (R-GGA-2022854)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.8.2.-", "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0045130 keratan sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006044 N-acetylglucosamine metabolic process;GO:0006790 sulfur compound metabolic process;GO:0018146 keratan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1P1-1", "uniprot_id": "A0A8V0Y1P1_CHICK", "mass": 54940.0, "length": 521, "protein_name": "Cone-rod homeobox", "gene_name": "CRX", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CRX", "gene_names_refseq": "", "protein_names_uniprotkb": "Cone-rod homeobox", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1P1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1Q0-1", "uniprot_id": "A0A8V0Y1Q0_CHICK", "mass": 80358.0, "length": 695, "protein_name": "Deuterosome assembly protein 1", "gene_name": "DEUP1", "organism": "Chicken", "refseq_name": "deuterosome assembly protein 1 isoform X4", "refseq_ac": "XP_040527862", "gene_names_uniprotkb": "DEUP1", "gene_names_refseq": "DEUP1", "protein_names_uniprotkb": "Deuterosome assembly protein 1; Coiled-coil domain-containing protein 67", "protein_names_refseq": "deuterosome assembly protein 1 isoform X4", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005814 centriole;GO:0098536 deuterosome", "go_biological_process": "GO:0030030 cell projection organization;GO:0007099 centriole replication;GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1R2-1", "uniprot_id": "A0A8V0Y1R2_CHICK", "mass": 13773.0, "length": 130, "protein_name": "H/ACA ribonucleoprotein complex subunit 2", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 2; Nucleolar protein family A member 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Common component of the spliceosome and rRNA processing machinery., [UniProtKB, UniProtKB]; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0031429 box H/ACA snoRNP complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0031120 snRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1R2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1W3-1", "uniprot_id": "A0A8V0Y1W3_CHICK", "mass": 39220.0, "length": 363, "protein_name": "HSF-type DNA-binding domain-containing protein", "gene_name": "HSFX6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HSFX6", "gene_names_refseq": "", "protein_names_uniprotkb": "HSF-type DNA-binding domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y1Y7-1", "uniprot_id": "A0A8V0Y1Y7_CHICK", "mass": 28377.0, "length": 247, "protein_name": "Protein ARV", "gene_name": "ARV1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ARV1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein ARV", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-191273)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0090181 regulation of cholesterol metabolic process;GO:0006665 sphingolipid metabolic process;GO:0032383 regulation of intracellular cholesterol transport;GO:0016125 sterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y1Y7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y204-1", "uniprot_id": "A0A8V0Y204_CHICK", "mass": 29969.0, "length": 275, "protein_name": "Survival of motor neuron", "gene_name": "SMN", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SMN", "gene_names_refseq": "", "protein_names_uniprotkb": "Survival of motor neuron", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030426 growth cone;GO:0043204 perikaryon;GO:0030018 Z disc;GO:0030137 COPI-coated vesicle", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y204-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y876-1", "uniprot_id": "A0A8V0Y876_CHICK", "mass": 37046.0, "length": 332, "protein_name": "Sidoreflexin", "gene_name": "SFXN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SFXN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sidoreflexin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015075 monoatomic ion transmembrane transporter activity;GO:0015180 L-alanine transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0006730 one-carbon metabolic process;GO:0140300 serine import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y876-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y528-1", "uniprot_id": "A0A8V0Y528_CHICK", "mass": 36593.0, "length": 333, "protein_name": "t-SNARE domain containing 1", "gene_name": "TSNARE1", "organism": "Chicken", "refseq_name": "t-SNARE domain-containing protein 1 isoform X1", "refseq_ac": "XP_025003957", "gene_names_uniprotkb": "TSNARE1", "gene_names_refseq": "TSNARE1", "protein_names_uniprotkb": "t-SNARE domain containing 1", "protein_names_refseq": "t-SNARE domain-containing protein 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420304)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_025003957.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0008021 synaptic vesicle;GO:0031201 SNARE complex", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0006886 intracellular protein transport;GO:0006906 vesicle fusion;GO:0048278 vesicle docking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y528-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y347-1", "uniprot_id": "A0A8V0Y347_CHICK", "mass": 127287.0, "length": 1126, "protein_name": "DNA-directed RNA polymerase subunit beta", "gene_name": "POLR3B", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "POLR3B", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-directed RNA polymerase subunit beta; 2.7.7.6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.48;2.7.7.6", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0032549 ribonucleoside binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000428 DNA-directed RNA polymerase complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5U0-1", "uniprot_id": "A0A8V0Y5U0_CHICK", "mass": 53656.0, "length": 477, "protein_name": "Mothers against decapentaplegic homolog", "gene_name": "SMAD2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SMAD2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mothers against decapentaplegic homolog; MAD homolog; Mothers against DPP homolog; SMAD family member", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1181150); (R-GGA-1502540); (R-GGA-2173788); (R-GGA-2173789); (R-GGA-2173795); (R-GGA-2173796); (R-GGA-5689880); (R-GGA-9617828)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0071144 heteromeric SMAD protein complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5U0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2U9-1", "uniprot_id": "A0A8V0Y2U9_CHICK", "mass": 87961.0, "length": 808, "protein_name": "Delta-like protein", "gene_name": "DLL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DLL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Delta-like protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0030957 Tat protein binding;GO:0097110 scaffold protein binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0016020 membrane;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045121 membrane raft", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0030182 neuron differentiation;GO:0009967 positive regulation of signal transduction;GO:0048468 cell development;GO:0048592 eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2U9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y327-1", "uniprot_id": "A0A8V0Y327_CHICK", "mass": 37615.0, "length": 327, "protein_name": "Translin-associated protein X", "gene_name": "TSNAX", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TSNAX", "gene_names_refseq": "", "protein_names_uniprotkb": "Translin-associated protein X; Translin-associated factor X", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-426486)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0043565 sequence-specific DNA binding;GO:0003723 RNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030422 siRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y327-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3A9-1", "uniprot_id": "A0A8V0Y3A9_CHICK", "mass": 186594.0, "length": 1690, "protein_name": "Pre-mRNA cleavage complex 2 protein Pcf11", "gene_name": "PCF11", "organism": "Chicken", "refseq_name": "pre-mRNA cleavage complex 2 protein Pcf11 isoform X1", "refseq_ac": "XP_004938948", "gene_names_uniprotkb": "PCF11", "gene_names_refseq": "PCF11", "protein_names_uniprotkb": "Pre-mRNA cleavage complex 2 protein Pcf11; Pre-mRNA cleavage complex II protein Pcf11", "protein_names_refseq": "pre-mRNA cleavage complex 2 protein Pcf11 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:419021); (R-GGA-6807505); (R-GGA-9770562)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004938948.3. COMPLETENESS: full length., [RefSeq]; Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005849 mRNA cleavage factor complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006369 termination of RNA polymerase II transcription;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4L6-1", "uniprot_id": "A0A8V0Y4L6_CHICK", "mass": 60548.0, "length": 523, "protein_name": "Lipid scramblase CLPTM1L", "gene_name": "CLPTM1L", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CLPTM1L", "gene_names_refseq": "", "protein_names_uniprotkb": "Lipid scramblase CLPTM1L; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1-like protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4L6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4N9-1", "uniprot_id": "A0A8V0Y4N9_CHICK", "mass": 35029.0, "length": 317, "protein_name": "Tomoregulin-1", "gene_name": "TMEFF1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TMEFF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tomoregulin-1; Transmembrane protein with EGF-like and one follistatin-like domain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0046597 host-mediated suppression of symbiont invasion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4N9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4T0-1", "uniprot_id": "A0A8V0Y4T0_CHICK", "mass": 187488.0, "length": 1671, "protein_name": "Kinesin family member 21A", "gene_name": "KIF21A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "KIF21A", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin family member 21A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6811434); (R-GGA-983189)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule;GO:0005938 cell cortex;GO:0030425 dendrite;GO:0030426 growth cone;GO:0005737 cytoplasm", "go_biological_process": "GO:0007018 microtubule-based movement;GO:1902667 regulation of axon guidance;GO:0031113 regulation of microtubule polymerization;GO:0043622 cortical microtubule organization;GO:0031114 regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4T0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6A5-1", "uniprot_id": "A0A8V0Y6A5_CHICK", "mass": 41439.0, "length": 369, "protein_name": "Histone PARylation factor 1", "gene_name": "HPF1", "organism": "Chicken", "refseq_name": "histone PARylation factor 1", "refseq_ac": "XP_420399", "gene_names_uniprotkb": "HPF1", "gene_names_refseq": "HPF1", "protein_names_uniprotkb": "Histone PARylation factor 1", "protein_names_refseq": "histone PARylation factor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:422431)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_420399.4. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0072572 poly-ADP-D-ribose binding;GO:0003682 chromatin binding;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0000785 chromatin;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6A5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6V0-1", "uniprot_id": "A0A8V0Y6V0_CHICK", "mass": 41464.0, "length": 365, "protein_name": "peptidylprolyl isomerase", "gene_name": "FKBP1B", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FKBP1B", "gene_names_refseq": "", "protein_names_uniprotkb": "peptidylprolyl isomerase; 5.2.1.8", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6V0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y744-1", "uniprot_id": "A0A8V0Y744_CHICK", "mass": 82267.0, "length": 746, "protein_name": "Elongation factor 1-delta", "gene_name": "EEF1D", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "EEF1D", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongation factor 1-delta", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-156842)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003746 translation elongation factor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005853 eukaryotic translation elongation factor 1 complex;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0071479 cellular response to ionizing radiation;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y744-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2E4-1", "uniprot_id": "A0A8V0Y2E4_CHICK", "mass": 49323.0, "length": 443, "protein_name": "Inositol oxygenase", "gene_name": "MIOX", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MIOX", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol oxygenase; 1.13.99.1; Myo-inositol oxygenase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1855183)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.13.99.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0050113 inositol oxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019310 inositol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2E4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7S3-1", "uniprot_id": "A0A8V0Y7S3_CHICK", "mass": 65731.0, "length": 572, "protein_name": "Zinc finger protein 512", "gene_name": "ZNF512", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ZNF512", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 512", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiates heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7S3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y8K1-1", "uniprot_id": "A0A8V0Y8K1_CHICK", "mass": 565067.0, "length": 4968, "protein_name": "Ryanodine receptor 2", "gene_name": "RYR2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RYR2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ryanodine receptor 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2672351); (R-GGA-5578775)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1", "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005509 calcium ion binding;GO:0005219 ryanodine-sensitive calcium-release channel activity;GO:0034236 protein kinase A catalytic subunit binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane;GO:0005790 smooth endoplasmic reticulum;GO:0042383 sarcolemma;GO:0030018 Z disc;GO:0034704 calcium channel complex", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0051775 response to redox state;GO:0001666 response to hypoxia;GO:0014850 response to muscle activity;GO:0035994 response to muscle stretch", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y8K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4D8-1", "uniprot_id": "A0A8V0Y4D8_CHICK", "mass": 59628.0, "length": 542, "protein_name": "Otoconin-90", "gene_name": "OC90", "organism": "Chicken", "refseq_name": "otoconin-90 isoform X1", "refseq_ac": "XP_015138610", "gene_names_uniprotkb": "OC90", "gene_names_refseq": "OC90", "protein_names_uniprotkb": "Otoconin-90", "protein_names_refseq": "otoconin-90 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420326)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015138610.1. COMPLETENESS: full length., [RefSeq]; Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0005543 phospholipid binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0006644 phospholipid metabolic process;GO:0046470 phosphatidylcholine metabolic process;GO:0046471 phosphatidylglycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4D8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4F4-1", "uniprot_id": "A0A8V0Y4F4_CHICK", "mass": 150307.0, "length": 1334, "protein_name": "Elongator complex protein 1", "gene_name": "IKBKAP", "organism": "Chicken", "refseq_name": "elongator complex protein 1", "refseq_ac": "XP_001231708", "gene_names_uniprotkb": "IKBKAP", "gene_names_refseq": "IKBKAP", "protein_names_uniprotkb": "Elongator complex protein 1", "protein_names_refseq": "elongator complex protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:427375)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_001231708.2. COMPLETENESS: full length., [RefSeq]; Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0033588 elongator holoenzyme complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4Q2-1", "uniprot_id": "A0A8V0Y4Q2_CHICK", "mass": 307809.0, "length": 2783, "protein_name": "Thyroglobulin", "gene_name": "TG", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TG", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyroglobulin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005179 hormone activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0042446 hormone biosynthetic process;GO:0030878 thyroid gland development;GO:0006590 thyroid hormone generation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4Q2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6E9-1", "uniprot_id": "A0A8V0Y6E9_CHICK", "mass": 90889.0, "length": 818, "protein_name": "Chloride channel protein", "gene_name": "CLCN3", "organism": "Chicken", "refseq_name": "H(+)/Cl(-) exchange transporter 3 isoform X3", "refseq_ac": "XP_004940988", "gene_names_uniprotkb": "CLCN3", "gene_names_refseq": "CLCN3", "protein_names_uniprotkb": "Chloride channel protein", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 3 isoform X3", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005254 chloride channel activity;GO:0062158 chloride:proton antiporter activity;GO:0072320 volume-sensitive chloride channel activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0045794 negative regulation of cell volume;GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6E9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y440-1", "uniprot_id": "A0A8V0Y440_CHICK", "mass": 53551.0, "length": 475, "protein_name": "Sorting nexin-17", "gene_name": "SNX17", "organism": "Chicken", "refseq_name": "sorting nexin-17 isoform X1", "refseq_ac": "XP_015140500", "gene_names_uniprotkb": "SNX17", "gene_names_refseq": "SNX17", "protein_names_uniprotkb": "Sorting nexin-17", "protein_names_refseq": "sorting nexin-17 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:421990)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0005769 early endosome;GO:0030659 cytoplasmic vesicle membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0006886 intracellular protein transport;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y440-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6U8-1", "uniprot_id": "A0A8V0Y6U8_CHICK", "mass": 60063.0, "length": 554, "protein_name": "ATP synthase subunit alpha", "gene_name": "ATP5F1AW", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATP5F1AW", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP synthase subunit alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:431564)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0043531 ADP binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6U8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3I0-1", "uniprot_id": "A0A8V0Y3I0_CHICK", "mass": 16911.0, "length": 152, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6", "gene_name": "NDUFA6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NDUFA6", "gene_names_refseq": "", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Complex I-B14; NADH-ubiquinone oxidoreductase B14 subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:427897)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain;GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3I0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6J4-1", "uniprot_id": "A0A8V0Y6J4_CHICK", "mass": 126622.0, "length": 1115, "protein_name": "PHD finger protein 20-like protein 1", "gene_name": "PHF20L1", "organism": "Chicken", "refseq_name": "PHD finger protein 20-like protein 1 isoform X3", "refseq_ac": "XP_040534799", "gene_names_uniprotkb": "PHF20L1", "gene_names_refseq": "PHF20L1", "protein_names_uniprotkb": "PHD finger protein 20-like protein 1", "protein_names_refseq": "PHD finger protein 20-like protein 1 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:420323)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140034 methylation-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0044545 NSL complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6J4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7S7-1", "uniprot_id": "A0A8V0Y7S7_CHICK", "mass": 48013.0, "length": 426, "protein_name": "Glutamine synthetase", "gene_name": "GLUL", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GLUL", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamine synthetase; 6.3.1.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396489); (R-GGA-210455); (R-GGA-8964539)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.3.1.2;4.1.1.15", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004356 glutamine synthetase activity;GO:0042802 identical protein binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0044297 cell body", "go_biological_process": "GO:0006542 glutamine biosynthetic process;GO:0008283 cell population proliferation;GO:0042254 ribosome biogenesis;GO:0045648 positive regulation of erythrocyte differentiation;GO:0097275 intracellular ammonium homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7S7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y646-1", "uniprot_id": "A0A8V0Y646_CHICK", "mass": 28068.0, "length": 255, "protein_name": "Clathrin light chain", "gene_name": "CLTB", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CLTB", "gene_names_refseq": "", "protein_names_uniprotkb": "Clathrin light chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-190873); (R-GGA-196025); (R-GGA-3928665); (R-GGA-432720); (R-GGA-5140745); (R-GGA-8856825); (R-GGA-8856828)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0030130 clathrin coat of trans-Golgi network vesicle;GO:0030132 clathrin coat of coated pit;GO:0030125 clathrin vesicle coat;GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y646-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3L9-1", "uniprot_id": "A0A8V0Y3L9_CHICK", "mass": 20145.0, "length": 188, "protein_name": "Transmembrane protein 14C", "gene_name": "TMEM14C", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TMEM14C", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 14C", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420851)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal heme biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y557-1", "uniprot_id": "A0A8V0Y557_CHICK", "mass": 132895.0, "length": 1191, "protein_name": "Nonsense-mediated mRNA decay factor", "gene_name": "SMG7", "organism": "Chicken", "refseq_name": "protein SMG7 isoform X1", "refseq_ac": "XP_015146031", "gene_names_uniprotkb": "SMG7", "gene_names_refseq": "SMG7", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor", "protein_names_refseq": "protein SMG7 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-975957)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052539.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a role in nonsense-mediated mRNA decay., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y557-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4W4-1", "uniprot_id": "A0A8V0Y4W4_CHICK", "mass": 141239.0, "length": 1242, "protein_name": "E3 ubiquitin-protein ligase NEDD4-like", "gene_name": "", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase NEDD4-like isoform X4", "refseq_ac": "XP_004949054", "gene_names_uniprotkb": "", "gene_names_refseq": "LOC124416941", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEDD4-like; 2.3.2.26; HECT-type E3 ubiquitin transferase NED4L", "protein_names_refseq": "E3 ubiquitin-protein ligase NEDD4-like isoform X4", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005771 multivesicular body;GO:0005737 cytoplasm", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0030154 cell differentiation;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0010766 negative regulation of sodium ion transport;GO:0048814 regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4W4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5C7-1", "uniprot_id": "A0A8V0Y5C7_CHICK", "mass": 54722.0, "length": 492, "protein_name": "E3 ubiquitin-protein ligase Hakai", "gene_name": "CBLL1", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase Hakai isoform 2", "refseq_ac": "NP_001384647", "gene_names_uniprotkb": "CBLL1", "gene_names_refseq": "CBLL1; HAKAI", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Hakai; 2.3.2.27; Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING-type E3 ubiquitin transferase Hakai", "protein_names_refseq": "Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; E3 ubiquitin-protein ligase Hakai isoform 2; E3 ubiquitin-protein ligase Hakai; RING-type E3 ubiquitin transferase Hakai; c-Cbl-like protein 1; casitas B-lineage lymphoma-transforming sequence-like protein 1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9766229); (R-GGA-983168); (R-GGA-9958810)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888539.147929.1, SRR12888496.290854.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1, BM485951.1, BI066854.1, BU379251.1, AJ394917.1 and AJ727912.1. On Nov 27, 2021 this sequence version replaced XP_015131197.1. Transcript Variant: This variant (2) has the short third exon. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.23;2.3.2.27;2.3.2.26;2.3.2.24;2.3.2.31;3.4.22.1;2.7.11.1;6.2.1.45;2.3.2.34", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5C7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6G8-1", "uniprot_id": "A0A8V0Y6G8_CHICK", "mass": 14742.0, "length": 138, "protein_name": "peptidyl-tRNA hydrolase", "gene_name": "PTRHD1", "organism": "Chicken", "refseq_name": "putative peptidyl-tRNA hydrolase PTRHD1 isoform X1", "refseq_ac": "XP_040524350", "gene_names_uniprotkb": "PTRHD1", "gene_names_refseq": "PTRHD1", "protein_names_uniprotkb": "peptidyl-tRNA hydrolase; 3.1.1.29", "protein_names_refseq": "putative peptidyl-tRNA hydrolase PTRHD1 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052575.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.1.29", "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y771-1", "uniprot_id": "A0A8V0Y771_CHICK", "mass": 17116.0, "length": 158, "protein_name": "Cysteine and tyrosine-rich protein 1", "gene_name": "CYYR1", "organism": "Chicken", "refseq_name": "cysteine and tyrosine-rich protein 1 isoform X2", "refseq_ac": "XP_040514720", "gene_names_uniprotkb": "CYYR1", "gene_names_refseq": "CYYR1", "protein_names_uniprotkb": "Cysteine and tyrosine-rich protein 1", "protein_names_refseq": "cysteine and tyrosine-rich protein 1 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052573.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y771-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y671-1", "uniprot_id": "A0A8V0Y671_CHICK", "mass": 24042.0, "length": 217, "protein_name": "RAB4A, member RAS onco family", "gene_name": "RAB4A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RAB4A", "gene_names_refseq": "", "protein_names_uniprotkb": "RAB4A, member RAS onco family", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421532); (R-GGA-8854214); (R-GGA-8875656)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.6.5.-;3.6.5.3;3.6.1.5", "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity;GO:0003924 GTPase activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031901 early endosome membrane;GO:0098978 glutamatergic synapse;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0015031 protein transport;GO:0032482 Rab protein signal transduction;GO:0030100 regulation of endocytosis;GO:0016192 vesicle-mediated transport;GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y671-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5I5-1", "uniprot_id": "A0A8V0Y5I5_CHICK", "mass": 50886.0, "length": 488, "protein_name": "Probable proton-coupled zinc antiporter SLC30A3", "gene_name": "SLC30A3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SLC30A3", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable proton-coupled zinc antiporter SLC30A3; Solute carrier family 30 member 3; Zinc transporter 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0010043 response to zinc ion;GO:0099180 zinc ion import into synaptic vesicle;GO:0140916 zinc ion import into lysosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y242-1", "uniprot_id": "A0A8V0Y242_CHICK", "mass": 68641.0, "length": 617, "protein_name": "Probable ATP-dependent RNA helicase DDX41", "gene_name": "DDX41", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DDX41", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX41; 3.6.4.13; DEAD box protein 41", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1834941); (R-GGA-3134975)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6;3.6.4.13;3.6.1.5;5.6.1.6;5.6.2.4;3.6.4.10;3.6.4.12;5.6.2.3;2.7.4.3;4.2.99.18;2.7.11.1;7.2.2.-;3.6.5.-;3.6.4.-;3.1.-.-;5.6.2.-;2.7.7.7;2.7.7.49;2.3.2.27;3.1.3.1;3.6.1.15;3.6.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0030154 cell differentiation;GO:0000398 mRNA splicing, via spliceosome;GO:0140896 cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y304-1", "uniprot_id": "A0A8V0Y304_CHICK", "mass": 104946.0, "length": 997, "protein_name": "Protocadherin alpha 7", "gene_name": "LOC121106708", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC121106708", "gene_names_refseq": "", "protein_names_uniprotkb": "Protocadherin alpha 7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y304-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4T8-1", "uniprot_id": "A0A8V0Y4T8_CHICK", "mass": 103539.0, "length": 930, "protein_name": "Cadherin related family member 3", "gene_name": "CDHR3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CDHR3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin related family member 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2E3-1", "uniprot_id": "A0A8V0Y2E3_CHICK", "mass": 132971.0, "length": 1192, "protein_name": "Multimerin-1", "gene_name": "MMRN1", "organism": "Chicken", "refseq_name": "multimerin-1 isoform X1", "refseq_ac": "XP_004941091", "gene_names_uniprotkb": "MMRN1", "gene_names_refseq": "MMRN1", "protein_names_uniprotkb": "Multimerin-1", "protein_names_refseq": "multimerin-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:428741); (R-GGA-114608); (R-GGA-5173105)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004941091.1. COMPLETENESS: full length., [RefSeq]; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0061045 negative regulation of wound healing;GO:1901731 positive regulation of platelet aggregation;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0033627 cell adhesion mediated by integrin;GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2E3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7C6-1", "uniprot_id": "A0A8V0Y7C6_CHICK", "mass": 148633.0, "length": 1418, "protein_name": "Latent transforming growth factor beta binding protein 4", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Latent transforming growth factor beta binding protein 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2129379); (R-GGA-2173789)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019838 growth factor binding;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2D1-1", "uniprot_id": "A0A8V0Y2D1_CHICK", "mass": 171138.0, "length": 1576, "protein_name": "GLI family zinc finger 3", "gene_name": "GLI3", "organism": "Chicken", "refseq_name": "transcriptional activator GLI3 isoform a", "refseq_ac": "NP_001258832", "gene_names_uniprotkb": "GLI3", "gene_names_refseq": "GLI3FL; GLI3", "protein_names_uniprotkb": "GLI family zinc finger 3", "protein_names_refseq": "GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome); GLI3 full length protein; transcriptional activator GLI3 isoform a; transcriptional activator GLI3", "tax_id": 9031, "disease": "", "pathway": " (gga:420769); (R-GGA-5610785); (R-GGA-5610787); (R-GGA-5632684)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "18590719;22373878;27720745", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.167909.1, SRR13267655.49773.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On or before Dec 14, 2021 this sequence version replaced XP_015137042.2, NP_001258832.1., [RefSeq]; CAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 processing., [RefSeq, PubMed]; Mutation has a destabilizing effect on GLI3R uncovering an unappreciated mechanism by which HOXD13 determines the patterning of the limb., [RefSeq, PubMed]; Results indicate that the Smo-induced Galpha(i) activity plays an insignificant role in the regulation of Gli3 processing and Shh-regulated neural tube patterning., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003682 chromatin binding;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0046639 negative regulation of alpha-beta T cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8V0Y2D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5A6-1", "uniprot_id": "A0A8V0Y5A6_CHICK", "mass": 104237.0, "length": 904, "protein_name": "Actinin, alpha 4", "gene_name": "ACTN4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ACTN4", "gene_names_refseq": "", "protein_names_uniprotkb": "Actinin, alpha 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-114608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005509 calcium ion binding;GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0120025 plasma membrane bounded cell projection;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0030036 actin cytoskeleton organization;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5A6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y343-1", "uniprot_id": "A0A8V0Y343_CHICK", "mass": 183251.0, "length": 1612, "protein_name": "Unc-13 homolog B", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unc-13 homolog B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-181429); (R-GGA-181430); (R-GGA-212676); (R-GGA-264642)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019992 diacylglycerol binding;GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0045202 synapse;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0016082 synaptic vesicle priming;GO:0016081 synaptic vesicle docking;GO:0061789 dense core granule priming", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y343-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y539-1", "uniprot_id": "A0A8V0Y539_CHICK", "mass": 51402.0, "length": 452, "protein_name": "bis(5'-adenosyl)-triphosphatase", "gene_name": "ENPP4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ENPP4", "gene_names_refseq": "", "protein_names_uniprotkb": "bis(5'-adenosyl)-triphosphatase; 3.6.1.29; AP3A hydrolase; Ectonucleotide pyrophosphatase/phosphodiesterase family member 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6798695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.16.2;3.1.4.1;3.6.1.9;3.6.1.29;3.6.5.2;2.7.7.51;3.6.2.1", "go_molecular_function": "GO:0046872 metal ion binding;GO:0047710 bis(5'-adenosyl)-triphosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0030194 positive regulation of blood coagulation;GO:0046130 purine ribonucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5K1-1", "uniprot_id": "A0A8V0Y5K1_CHICK", "mass": 104611.0, "length": 912, "protein_name": "Autotaxin", "gene_name": "ENPP2", "organism": "Chicken", "refseq_name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X8", "refseq_ac": "XP_015138516", "gene_names_uniprotkb": "ENPP2", "gene_names_refseq": "ENPP2", "protein_names_uniprotkb": "Autotaxin; 3.1.4.39; 3.1.4.4; Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Extracellular lysophospholipase D", "protein_names_refseq": "ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X8", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.39;3.1.4.4", "go_molecular_function": "GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0004630 phospholipase D activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0006935 chemotaxis;GO:0006955 immune response;GO:0030149 sphingolipid catabolic process;GO:2000394 positive regulation of lamellipodium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5K1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5Z2-1", "uniprot_id": "A0A8V0Y5Z2_CHICK", "mass": 120561.0, "length": 1038, "protein_name": "SNF2 related chromatin remodeling ATPase 5", "gene_name": "SMARCA5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SMARCA5", "gene_names_refseq": "", "protein_names_uniprotkb": "SNF2 related chromatin remodeling ATPase 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5250924); (R-GGA-5693565); (R-GGA-606279)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0031491 nucleosome binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0031010 ISWI-type complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006281 DNA repair;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006334 nucleosome assembly;GO:0045945 positive regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5Z2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y610-1", "uniprot_id": "A0A8V0Y610_CHICK", "mass": 56599.0, "length": 497, "protein_name": "Hexosyltransferase", "gene_name": "B3GALNT2", "organism": "Chicken", "refseq_name": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2 isoform X1", "refseq_ac": "XP_040554207", "gene_names_uniprotkb": "B3GALNT2", "gene_names_refseq": "B3GALNT2", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8932505)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. 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This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. 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This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y715-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y720-1", "uniprot_id": "A0A8V0Y720_CHICK", "mass": 89037.0, "length": 812, "protein_name": "Solute carrier family 26 member 5", "gene_name": "SLC26A5", "organism": "Chicken", "refseq_name": "prestin isoform X1", "refseq_ac": "XP_046763026", "gene_names_uniprotkb": "SLC26A5", "gene_names_refseq": "SLC26A5", "protein_names_uniprotkb": "Solute carrier family 26 member 5", "protein_names_refseq": "prestin isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052573.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0030507 spectrin binding;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016328 lateral plasma membrane;GO:0120249 lateral wall of outer hair cell", "go_biological_process": "GO:0055085 transmembrane transport;GO:0019532 oxalate transport;GO:0007605 sensory perception of sound;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y720-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y736-1", "uniprot_id": "A0A8V0Y736_CHICK", "mass": 39352.0, "length": 360, "protein_name": "Methionine adenosyltransferase 2 subunit beta", "gene_name": "MAT2B", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MAT2B", "gene_names_refseq": "", "protein_names_uniprotkb": "Methionine adenosyltransferase 2 subunit beta; Methionine adenosyltransferase II beta", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-156581); (R-GGA-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048269 methionine adenosyltransferase complex", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0006556 S-adenosylmethionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y736-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7K7-1", "uniprot_id": "A0A8V0Y7K7_CHICK", "mass": 37554.0, "length": 345, "protein_name": "SUMO-activating enzyme subunit 1", "gene_name": "CCDC9", "organism": "Chicken", "refseq_name": "SUMO-activating enzyme subunit 1 isoform X3", "refseq_ac": "XP_040550122", "gene_names_uniprotkb": "CCDC9", "gene_names_refseq": "CCDC9", "protein_names_uniprotkb": "SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A", "protein_names_refseq": "SUMO-activating enzyme subunit 1 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3065676); (R-GGA-3065678)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052610.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008641 ubiquitin-like modifier activating enzyme activity;GO:0019948 SUMO activating enzyme activity;GO:0046982 protein heterodimerization activity;GO:0043008 ATP-dependent protein binding;GO:0044388 small protein activating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031510 SUMO activating enzyme complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016925 protein sumoylation;GO:0033235 positive regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3R7-1", "uniprot_id": "A0A8V0Y3R7_CHICK", "mass": 31073.0, "length": 269, "protein_name": "E3 SUMO-protein ligase NSE2", "gene_name": "NSMCE2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NSMCE2", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; Non-structural maintenance of chromosomes element 2 homolog", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3108214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019789 SUMO transferase activity;GO:0008270 zinc ion binding;GO:0061665 SUMO ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030915 Smc5-Smc6 complex;GO:0016605 PML body;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0016925 protein sumoylation;GO:0045842 positive regulation of mitotic metaphase/anaphase transition;GO:0090398 cellular senescence;GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3R7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y8C9-1", "uniprot_id": "A0A8V0Y8C9_CHICK", "mass": 55074.0, "length": 480, "protein_name": "Phenylalanine-4-hydroxylase", "gene_name": "PAH", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PAH", "gene_names_refseq": "", "protein_names_uniprotkb": "Phenylalanine-4-hydroxylase; 1.14.16.1; Phe-4-monooxygenase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8964208)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.14.16.1", "go_molecular_function": "GO:0005506 iron ion binding;GO:0004505 phenylalanine 4-monooxygenase activity", "go_cellular_component": "", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006571 tyrosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y8C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3G4-1", "uniprot_id": "A0A8V0Y3G4_CHICK", "mass": 45812.0, "length": 413, "protein_name": "Sulfotransferase", "gene_name": "LOC415852", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC415852", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase; 2.8.2.-", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3G4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2F4-1", "uniprot_id": "A0A8V0Y2F4_CHICK", "mass": 55352.0, "length": 482, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC101750560", "organism": "Chicken", "refseq_name": "uncharacterized LOC101750560", "refseq_ac": "NP_001393659", "gene_names_uniprotkb": "LOC101750560", "gene_names_refseq": "AKT2; LOC101750560", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "AKT serine/threonine kinase 2; protein serine/threonine kinase; uncharacterized LOC101750560; v-akt murine thymoma viral oncogene homolog 2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.258718.1, SRR13267655.146148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000454.1. On or before May 20, 2022 this sequence version replaced XP_025000271.1, XP_040550905.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0050821 protein stabilization;GO:0008286 insulin receptor signaling pathway;GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6N9-1", "uniprot_id": "A0A8V0Y6N9_CHICK", "mass": 60138.0, "length": 551, "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "NAPRT", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NAPRT", "gene_names_refseq": "", "protein_names_uniprotkb": "Nicotinate phosphoribosyltransferase; 6.3.4.21", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-196807); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.6.4;3.4.21.4;2.3.3.8;2.7.11.13;3.2.1.31;3.4.19.9;3.4.14.1;3.1.6.8;6.3.4.21;5.3.4.1;3.6.4.6;1.11.1.27;3.2.1.51;3.2.1.-;2.7.10.2;3.2.1.23;1.6.5.5;2.7.11.24;3.4.14.2;5.3.99.3;2.4.1.1;3.1.6.14;3.5.4.4;3.5.1.26;3.2.1.52;3.2.1.17;3.1.27.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016740 transferase activity;GO:0004516 nicotinate phosphoribosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0006979 response to oxidative stress;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6N9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4K0-1", "uniprot_id": "A0A8V0Y4K0_CHICK", "mass": 40046.0, "length": 361, "protein_name": "Histone-lysine N-methyltransferase SETD7", "gene_name": "SETD7", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SETD7", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD7; 2.1.1.364; SET domain-containing protein 7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.1.1.354;2.1.1.364;2.1.1.361;2.1.1.-", "go_molecular_function": "GO:0140945 histone H3K4 monomethyltransferase activity;GO:0002039 p53 binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140938 histone H3 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0032259 methylation;GO:0045893 positive regulation of DNA-templated transcription;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4K0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6K9-1", "uniprot_id": "A0A8V0Y6K9_CHICK", "mass": 123552.0, "length": 1089, "protein_name": "Formin like 2", "gene_name": "FMNL2", "organism": "Chicken", "refseq_name": "formin-like protein 2 isoform X5", "refseq_ac": "XP_040560359", "gene_names_uniprotkb": "FMNL2", "gene_names_refseq": "FMNL2", "protein_names_uniprotkb": "Formin like 2", "protein_names_refseq": "formin-like protein 2 isoform X5", "tax_id": 9031, "disease": "", "pathway": " (gga:771739); (R-GGA-5663220); (R-GGA-9013106)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0022604 regulation of cell morphogenesis;GO:0016477 cell migration;GO:0008360 regulation of cell shape;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6K9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y523-1", "uniprot_id": "A0A8V0Y523_CHICK", "mass": 277418.0, "length": 2550, "protein_name": "Stabilin 2", "gene_name": "STAB2", "organism": "Chicken", "refseq_name": "stabilin-2 isoform X1", "refseq_ac": "XP_040514194", "gene_names_uniprotkb": "STAB2", "gene_names_refseq": "STAB2", "protein_names_uniprotkb": "Stabilin 2", "protein_names_refseq": "stabilin-2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2142845); (R-GGA-2160916); (R-GGA-3000497)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005540 hyaluronic acid binding;GO:0005044 scavenger receptor activity;GO:0005041 low-density lipoprotein particle receptor activity;GO:0030169 low-density lipoprotein particle binding", "go_cellular_component": "GO:0016020 membrane;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007155 cell adhesion;GO:0050830 defense response to Gram-positive bacterium;GO:0006898 receptor-mediated endocytosis;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y523-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2H7-1", "uniprot_id": "A0A8V0Y2H7_CHICK", "mass": 12785.0, "length": 118, "protein_name": "Cocaine- and amphetamine-regulated transcript protein", "gene_name": "CARTPT", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CARTPT", "gene_names_refseq": "", "protein_names_uniprotkb": "Cocaine- and amphetamine-regulated transcript protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:100858488)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0030141 secretory granule", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0007268 chemical synaptic transmission;GO:0008343 adult feeding behavior;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6Y5-1", "uniprot_id": "A0A8V0Y6Y5_CHICK", "mass": 63231.0, "length": 544, "protein_name": "Dynein regulatory complex subunit 4", "gene_name": "GAS8", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GAS8", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein regulatory complex subunit 4; Growth arrest-specific protein 8", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005874 microtubule;GO:0031514 motile cilium;GO:0097229 sperm end piece;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0048870 cell motility;GO:0045880 positive regulation of smoothened signaling pathway;GO:0030317 flagellated sperm motility;GO:0061512 protein localization to cilium;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6Y5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4Y4-1", "uniprot_id": "A0A8V0Y4Y4_CHICK", "mass": 99794.0, "length": 885, "protein_name": "Semaphorin-4D", "gene_name": "SEMA4D", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SEMA4D", "gene_names_refseq": "", "protein_names_uniprotkb": "Semaphorin-4D", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396331); (R-GGA-416550); (R-GGA-416572); (R-GGA-416700)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0004888 transmembrane signaling receptor activity;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098982 GABA-ergic synapse;GO:0002116 semaphorin receptor complex;GO:0005615 extracellular space", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4Y4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y743-1", "uniprot_id": "A0A8V0Y743_CHICK", "mass": 93381.0, "length": 817, "protein_name": "Dynein regulatory complex protein 1", "gene_name": "DRC1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DRC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein regulatory complex protein 1; Coiled-coil domain-containing protein 164", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422009)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005858 axonemal dynein complex;GO:0005930 axoneme", "go_biological_process": "GO:0070286 axonemal dynein complex assembly;GO:0060285 cilium-dependent cell motility;GO:0003352 regulation of cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y743-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y798-1", "uniprot_id": "A0A8V0Y798_CHICK", "mass": 175429.0, "length": 1583, "protein_name": "Synaptojanin-1", "gene_name": "SYNJ1", "organism": "Chicken", "refseq_name": "synaptojanin-1 isoform X8", "refseq_ac": "XP_015155337", "gene_names_uniprotkb": "SYNJ1", "gene_names_refseq": "SYNJ1", "protein_names_uniprotkb": "Synaptojanin-1; 3.1.3.36; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1", "protein_names_refseq": "synaptojanin-1 isoform X8", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1660499); (R-GGA-1855183); (R-GGA-1855204); (R-GGA-8856828)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 1, 2022 this sequence version replaced XP_015155337.2. COMPLETENESS: full length., [RefSeq]; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.95;5.6.1.6;3.1.3.36;2.7.10.1;3.1.3.86;3.1.3.56;2.7.11.1;3.6.5.5;2.3.2.27;3.6.4.-;2.7.1.134;2.7.1.159;3.6.5.2", "go_molecular_function": "GO:0003723 RNA binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006897 endocytosis;GO:0046856 phosphatidylinositol dephosphorylation;GO:0007612 learning;GO:0048488 synaptic vesicle endocytosis;GO:1904980 positive regulation of endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6Q6-1", "uniprot_id": "A0A8V0Y6Q6_CHICK", "mass": 526947.0, "length": 4724, "protein_name": "Ryanodine receptor 1", "gene_name": "LOC101748756", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC101748756", "gene_names_refseq": "", "protein_names_uniprotkb": "Ryanodine receptor 1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005219 ryanodine-sensitive calcium-release channel activity", "go_cellular_component": "GO:0033017 sarcoplasmic reticulum membrane;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0031674 I band", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0001666 response to hypoxia;GO:0051209 release of sequestered calcium ion into cytosol;GO:0071313 cellular response to caffeine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6Q6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7D3-1", "uniprot_id": "A0A8V0Y7D3_CHICK", "mass": 47733.0, "length": 426, "protein_name": "Proteinase-activated receptor 1", "gene_name": "F2RL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "F2RL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteinase-activated receptor 1; Thrombin receptor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-375276); (R-GGA-416476); (R-GGA-456926); (R-GGA-9769739)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0005102 signaling receptor binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031094 platelet dense tubular network;GO:0005769 early endosome;GO:0009986 cell surface;GO:0045202 synapse", "go_biological_process": "GO:0007596 blood coagulation;GO:1900134 negative regulation of renin secretion into blood stream;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008285 negative regulation of cell population proliferation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5B7-1", "uniprot_id": "A0A8V0Y5B7_CHICK", "mass": 42891.0, "length": 383, "protein_name": "Tripartite motif-containing protein 54", "gene_name": "TRIM54", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TRIM54", "gene_names_refseq": "", "protein_names_uniprotkb": "Tripartite motif-containing protein 54; 2.3.2.27", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May bind and stabilize microtubules during myotubes formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008017 microtubule binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005874 microtubule;GO:0030018 Z disc;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7W3-1", "uniprot_id": "A0A8V0Y7W3_CHICK", "mass": 55760.0, "length": 502, "protein_name": "tRNA-specific adenosine deaminase 1", "gene_name": "ADAT1", "organism": "Chicken", "refseq_name": "tRNA-specific adenosine deaminase 1 isoform X3", "refseq_ac": "XP_015148094", "gene_names_uniprotkb": "ADAT1", "gene_names_refseq": "ADAT1", "protein_names_uniprotkb": "tRNA-specific adenosine deaminase 1; 3.5.4.34; tRNA-specific adenosine-37 deaminase", "protein_names_refseq": "tRNA-specific adenosine deaminase 1 isoform X3", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015148094.1. COMPLETENESS: full length., [RefSeq]; Specifically deaminates adenosine-37 to inosine in tRNA-Ala., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.4.34", "go_molecular_function": "GO:0003723 RNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0043829 tRNA-specific adenosine-37 deaminase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7W3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3C6-1", "uniprot_id": "A0A8V0Y3C6_CHICK", "mass": 137643.0, "length": 1200, "protein_name": "Transcription initiation factor TFIID subunit 2", "gene_name": "TAF2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TAF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 2; TBP-associated factor 150 kDa; Transcription initiation factor TFIID 150 kDa subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:428389); (R-GGA-674695); (R-GGA-73776); (R-GGA-73779); (R-GGA-75953); (R-GGA-76042)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005669 transcription factor TFIID complex;GO:0033276 transcription factor TFTC complex", "go_biological_process": "GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0042789 mRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3C6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y824-1", "uniprot_id": "A0A8V0Y824_CHICK", "mass": 32460.0, "length": 288, "protein_name": "Galactose-1-phosphate uridylyltransferase", "gene_name": "GALT", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GALT", "gene_names_refseq": "", "protein_names_uniprotkb": "Galactose-1-phosphate uridylyltransferase; 2.7.7.12", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-70370)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.7.12", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006012 galactose metabolic process;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006011 UDP-alpha-D-glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y824-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6K7-1", "uniprot_id": "A0A8V0Y6K7_CHICK", "mass": 73334.0, "length": 627, "protein_name": "Protein Spindly", "gene_name": "SPDL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SPDL1; CCDC99", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-141430); (R-GGA-141444); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-5663220); (R-GGA-9648025)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0043515 kinetochore binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0000940 outer kinetochore;GO:0000922 spindle pole;GO:0005634 nucleus", "go_biological_process": "GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0034501 protein localization to kinetochore;GO:0016477 cell migration;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6K7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y218-1", "uniprot_id": "A0A8V0Y218_CHICK", "mass": 54508.0, "length": 487, "protein_name": "Ribitol-5-phosphate transferase", "gene_name": "LOC121108177", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC121108177", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribitol-5-phosphate transferase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9939291)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0043236 laminin binding;GO:0002162 dystroglycan binding;GO:0016780 phosphotransferase activity, for other substituted phosphate groups", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005791 rough endoplasmic reticulum;GO:0042383 sarcolemma;GO:0098723 skeletal muscle myofibril", "go_biological_process": "GO:0051262 protein tetramerization;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y237-1", "uniprot_id": "A0A8V0Y237_CHICK", "mass": 24330.0, "length": 222, "protein_name": "ATP synthase peripheral stalk subunit F6, mitochondrial", "gene_name": "ATP5J", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATP5J", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit F6, mitochondrial; ATP synthase peripheral stalk subunit F6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-163210); (R-GGA-8949613); (R-GGA-9837999)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit F6, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y237-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y248-1", "uniprot_id": "A0A8V0Y248_CHICK", "mass": 82995.0, "length": 741, "protein_name": "Sulfhydryl oxidase", "gene_name": "QSOX1", "organism": "Chicken", "refseq_name": "sulfhydryl oxidase 1 precursor", "refseq_ac": "NP_989456", "gene_names_uniprotkb": "QSOX1", "gene_names_refseq": "QSCN6; QSOX1; QSOX; SOX", "protein_names_uniprotkb": "Sulfhydryl oxidase; 1.8.3.2", "protein_names_refseq": "sulfhydryl oxidase 1 precursor; sulfhydryl oxidase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:373914); (R-GGA-114608); (R-GGA-381426); (R-GGA-6798695); (R-GGA-8957275)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY112666.1, SRR13267649.86117.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000237.1. On Oct 4, 2021 this sequence version replaced NP_989456.1., [RefSeq]; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.4.21.4;3.1.3.48;1.11.1.27;1.16.3.1;1.11.1.9;1.16.3.4;4.1.2.13;3.4.19.9;3.2.1.166;5.3.4.1;3.5.1.3;2.3.2.5;1.8.3.2;3.3.2.6;2.7.1.35;1.8.3.5;2.4.1.145;2.7.10.2;3.4.24.35;3.5.4.5;3.6.5.2;3.4.21.41;1.1.1.42;3.4.21.69;3.4.21.112;3.1.1.3;1.4.3.-;3.6.1.6;3.2.1.51;2.3.2.13;3.4.24.7;5.4.2.2;3.4.21.7;3.2.1.17;3.4.23.5;5.3.99.2;3.5.1.23", "go_molecular_function": "GO:0071949 FAD binding;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0070062 extracellular exosome", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0006457 protein folding;GO:0016242 negative regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6V2-1", "uniprot_id": "A0A8V0Y6V2_CHICK", "mass": 138015.0, "length": 1225, "protein_name": "Nucleolar protein 6", "gene_name": "NOL6", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NOL6", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleolar protein 6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:100858366); (R-GGA-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome;GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006409 tRNA export from nucleus;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6V2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y8G8-1", "uniprot_id": "A0A8V0Y8G8_CHICK", "mass": 459170.0, "length": 4004, "protein_name": "Dynein axonemal heavy chain 7", "gene_name": "DNAH7", "organism": "Chicken", "refseq_name": "dynein axonemal heavy chain 7 isoform X1", "refseq_ac": "XP_003641622", "gene_names_uniprotkb": "DNAH7", "gene_names_refseq": "DNAH7", "protein_names_uniprotkb": "Dynein axonemal heavy chain 7; Axonemal beta dynein heavy chain 7; Ciliary dynein heavy chain 7", "protein_names_refseq": "dynein axonemal heavy chain 7 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:424048)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_003641622.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097227 sperm annulus", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y8G8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y281-1", "uniprot_id": "A0A8V0Y281_CHICK", "mass": 75215.0, "length": 689, "protein_name": "Nuclear receptor subfamily 4 group A member 3", "gene_name": "NR4A3", "organism": "Chicken", "refseq_name": "nuclear receptor subfamily 4 group A member 3 isoform X1", "refseq_ac": "XP_015137891", "gene_names_uniprotkb": "NR4A3", "gene_names_refseq": "NR4A3", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 3", "protein_names_refseq": "nuclear receptor subfamily 4 group A member 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420996); (R-GGA-383280)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015137891.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0038097 positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y281-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y298-1", "uniprot_id": "A0A8V0Y298_CHICK", "mass": 51350.0, "length": 470, "protein_name": "N-acetyllactosamine synthase", "gene_name": "B4GALT1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "B4GALT1", "gene_names_refseq": "", "protein_names_uniprotkb": "N-acetyllactosamine synthase; 2.4.1.90; N-acetyllactosamine synthase; Nal synthase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2022854); (R-GGA-2534343); (R-GGA-5653890); (R-GGA-6798695); (R-GGA-975577)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-;3.4.16.2;7.6.2.1;3.4.23.-;3.6.5.2;3.4.24.11;2.4.1.90;3.1.3.48;2.5.1.18;3.4.11.-;3.2.1.25;3.1.3.2;3.2.1.17", "go_molecular_function": "GO:0030145 manganese ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity;GO:0004461 lactose synthase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane;GO:0009897 external side of plasma membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006487 protein N-linked glycosylation;GO:0009312 oligosaccharide biosynthetic process;GO:0061755 positive regulation of circulating fibrinogen levels;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y298-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2B8-1", "uniprot_id": "A0A8V0Y2B8_CHICK", "mass": 272156.0, "length": 2421, "protein_name": "Polycystin 1 like 2/pseudo", "gene_name": "PKD1L2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PKD1L2", "gene_names_refseq": "", "protein_names_uniprotkb": "Polycystin 1 like 2/pseudo", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050982 detection of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2B8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2D5-1", "uniprot_id": "A0A8V0Y2D5_CHICK", "mass": 56700.0, "length": 495, "protein_name": "Origin recognition complex subunit 4", "gene_name": "ORC4", "organism": "Chicken", "refseq_name": "origin recognition complex subunit 4 isoform X1", "refseq_ac": "XP_422152", "gene_names_uniprotkb": "ORC4", "gene_names_refseq": "ORC4", "protein_names_uniprotkb": "Origin recognition complex subunit 4", "protein_names_refseq": "origin recognition complex subunit 4 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-176187); (R-GGA-68616); (R-GGA-68689); (R-GGA-68949); (R-GGA-68962)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 1, 2022 this sequence version replaced XP_422152.6. COMPLETENESS: full length., [RefSeq]; Component of the origin recognition complex (ORC) that binds origins of replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0003688 DNA replication origin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000808 origin recognition complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006260 DNA replication;GO:0051258 protein polymerization;GO:0006270 DNA replication initiation;GO:0040038 polar body extrusion after meiotic divisions", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2D5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2E5-1", "uniprot_id": "A0A8V0Y2E5_CHICK", "mass": 65822.0, "length": 572, "protein_name": "Hyaluronan synthase 2", "gene_name": "HAS2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HAS2", "gene_names_refseq": "", "protein_names_uniprotkb": "Hyaluronan synthase 2; 2.4.1.212; Hyaluronate synthase 2; Hyaluronic acid synthase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2142845)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.212", "go_molecular_function": "GO:0042802 identical protein binding;GO:0050501 hyaluronan synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0044853 plasma membrane raft;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0001570 vasculogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2E5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6H1-1", "uniprot_id": "A0A8V0Y6H1_CHICK", "mass": 56405.0, "length": 505, "protein_name": "Nucleotide exchange factor SIL1", "gene_name": "SIL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SIL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleotide exchange factor SIL1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6H1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y778-1", "uniprot_id": "A0A8V0Y778_CHICK", "mass": 94537.0, "length": 837, "protein_name": "Anaphase-promoting complex subunit 4", "gene_name": "ANAPC4", "organism": "Chicken", "refseq_name": "anaphase-promoting complex subunit 4 isoform X1", "refseq_ac": "XP_040555231", "gene_names_uniprotkb": "ANAPC4", "gene_names_refseq": "ANAPC4", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 4; Cyclosome subunit 4", "protein_names_refseq": "anaphase-promoting complex subunit 4 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-141430); (R-GGA-174048); (R-GGA-174084); (R-GGA-174154); (R-GGA-174178); (R-GGA-174184); (R-GGA-176407); (R-GGA-176408); (R-GGA-176409); (R-GGA-176412); (R-GGA-179409); (R-GGA-2467813); (R-GGA-2559582); (R-GGA-68867); (R-GGA-69017); (R-GGA-983168)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005680 anaphase-promoting complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0030071 regulation of mitotic metaphase/anaphase transition;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y778-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2H3-1", "uniprot_id": "A0A8V0Y2H3_CHICK", "mass": 32712.0, "length": 297, "protein_name": "small monomeric GTPase", "gene_name": "RAB10", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RAB10", "gene_names_refseq": "", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6798695); (R-GGA-8876198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.5.2;3.6.5.5;3.4.24.11;2.4.1.90;3.6.5.-;3.1.3.48;3.6.5.3;3.4.11.-;3.6.1.5", "go_molecular_function": "GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0031489 myosin V binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0032869 cellular response to insulin stimulus;GO:0045055 regulated exocytosis;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2H3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2I5-1", "uniprot_id": "A0A8V0Y2I5_CHICK", "mass": 39977.0, "length": 354, "protein_name": "Cyclin-dependent kinase 7", "gene_name": "CDK7", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CDK7", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-dependent kinase 7; 2.7.11.22; 2.7.11.23; Cell division protein kinase 7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5696395); (R-GGA-674695); (R-GGA-6781823); (R-GGA-6782135); (R-GGA-6782210); (R-GGA-6796648); (R-GGA-6807505); (R-GGA-69200); (R-GGA-69202); (R-GGA-69231); (R-GGA-69273); (R-GGA-69656); (R-GGA-72086); (R-GGA-73772); (R-GGA-73776); (R-GGA-73779); (R-GGA-73863); (R-GGA-75953); (R-GGA-75955); (R-GGA-76042); (R-GGA-77075); (R-GGA-8939236)", "pathway_count": 22, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.3.2.27;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;3.6.4.13;6.5.1.1;2.7.11.38;2.7.11.23;3.1.3.16;2.7.7.7;2.7.11.26;5.2.1.8;3.4.19.12;2.4.2.-;2.4.2.30;2.7.7.6;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.3.1.48;5.6.2.4;2.7.11.11", "go_molecular_function": "GO:0005524 ATP binding;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0008094 ATP-dependent activity, acting on DNA;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0140836 RNA polymerase II CTD heptapeptide repeat S5 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0070985 transcription factor TFIIK complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0050821 protein stabilization;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2I5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2K8-1", "uniprot_id": "A0A8V0Y2K8_CHICK", "mass": 77391.0, "length": 692, "protein_name": "Centrosomal protein POC5", "gene_name": "POC5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "POC5", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein POC5; Protein of centriole 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for the assembly of the distal half of centrioles, required for centriole elongation. Acts as a negative regulator of centriole elongation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005814 centriole;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2L7-1", "uniprot_id": "A0A8V0Y2L7_CHICK", "mass": 57102.0, "length": 535, "protein_name": "Iroquois homeobox 2", "gene_name": "IRX2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "IRX2", "gene_names_refseq": "", "protein_names_uniprotkb": "Iroquois homeobox 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0072086 specification of loop of Henle identity;GO:0072272 proximal/distal pattern formation involved in metanephric nephron development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0048468 cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2L7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2M4-1", "uniprot_id": "A0A8V0Y2M4_CHICK", "mass": 146777.0, "length": 1322, "protein_name": "Adhesion G protein-coupled receptor A3", "gene_name": "ADGRA3", "organism": "Chicken", "refseq_name": "adhesion G protein-coupled receptor A3", "refseq_ac": "XP_420763", "gene_names_uniprotkb": "ADGRA3", "gene_names_refseq": "ADGRA3", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor A3; G-protein coupled receptor 125", "protein_names_refseq": "adhesion G protein-coupled receptor A3", "tax_id": 9031, "disease": "", "pathway": " (gga:422817)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_420763.4. COMPLETENESS: full length., [RefSeq]; Orphan receptor that may have a role in planar cell polarity pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2M4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2M7-1", "uniprot_id": "A0A8V0Y2M7_CHICK", "mass": 89353.0, "length": 800, "protein_name": "Exonuclease 1", "gene_name": "EXO1", "organism": "Chicken", "refseq_name": "exonuclease 1", "refseq_ac": "NP_001382916", "gene_names_uniprotkb": "EXO1", "gene_names_refseq": "EXO1", "protein_names_uniprotkb": "Exonuclease 1; 3.1.-.-", "protein_names_refseq": "exonuclease 1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5358565); (R-GGA-5685938); (R-GGA-5685942); (R-GGA-5693537); (R-GGA-5693568); (R-GGA-5693579); (R-GGA-5693607); (R-GGA-5693616)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "34228493", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267660.20267.1, SRR13267654.73081.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1, BU251015.1, AB084249.1, CV856730.1 and BU266643.1. On Sep 13, 2021 this sequence version replaced XP_419550.6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis., [UniProtKB, UniProtKB]; FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.1.48;2.7.11.1;6.5.1.1;5.6.2.4;3.1.-.-;2.7.7.7;5.6.2.1;3.6.4.12;2.3.2.27;3.6.4.-;5.6.2.3", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0006310 DNA recombination;GO:0006298 mismatch repair;GO:0051321 meiotic cell cycle;GO:0002376 immune system process;GO:0110025 DNA strand resection involved in replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8V0Y2M7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2R0-1", "uniprot_id": "A0A8V0Y2R0_CHICK", "mass": 27726.0, "length": 260, "protein_name": "Exosome complex component RRP40", "gene_name": "EXOSC3", "organism": "Chicken", "refseq_name": "exosome complex component RRP40", "refseq_ac": "NP_001186445", "gene_names_uniprotkb": "EXOSC3", "gene_names_refseq": "EXOSC3", "protein_names_uniprotkb": "Exosome complex component RRP40; Exosome component 3; Ribosomal RNA-processing protein 40", "protein_names_refseq": "exosome complex component RRP40; exosome complex exonuclease RRP40", "tax_id": 9031, "disease": "", "pathway": " (gga:423626); (R-GGA-429958); (R-GGA-450385); (R-GGA-6791226); (R-GGA-9930044)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU369066.1, BX930009.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000227.1. On Dec 1, 2021 this sequence version replaced NP_001186445.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000791 euchromatin;GO:0000176 nuclear exosome (RNase complex)", "go_biological_process": "GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0034475 U4 snRNA 3'-end processing;GO:0045006 DNA deamination;GO:0071034 CUT catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2R0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2S7-1", "uniprot_id": "A0A8V0Y2S7_CHICK", "mass": 174138.0, "length": 1587, "protein_name": "Tensin 3", "gene_name": "TNS3", "organism": "Chicken", "refseq_name": "tensin-3 isoform X1", "refseq_ac": "XP_015131337", "gene_names_uniprotkb": "TNS3", "gene_names_refseq": "TNS3", "protein_names_uniprotkb": "Tensin 3", "protein_names_refseq": "tensin-3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8875513)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015131337.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0042995 cell projection", "go_biological_process": "GO:0035022 positive regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2S7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2U3-1", "uniprot_id": "A0A8V0Y2U3_CHICK", "mass": 105127.0, "length": 934, "protein_name": "DNA polymerase kappa", "gene_name": "POLK", "organism": "Chicken", "refseq_name": "DNA polymerase kappa isoform X1", "refseq_ac": "XP_046761132", "gene_names_uniprotkb": "POLK", "gene_names_refseq": "POLK", "protein_names_uniprotkb": "DNA polymerase kappa; 2.7.7.7; DINB protein", "protein_names_refseq": "DNA polymerase kappa isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5655862); (R-GGA-5656169); (R-GGA-5685942); (R-GGA-5693537); (R-GGA-5696397); (R-GGA-5696400); (R-GGA-6782135); (R-GGA-6782210)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.3.2.27;2.7.7.7;2.7.7.102;2.3.1.48;3.6.4.13;2.7.11.1;6.5.1.1;3.4.19.12;5.6.2.4;2.7.7.49;2.7.11.22;2.7.11.23;2.7.11.24;3.1.-.-;5.2.1.8;2.4.2.-;2.4.2.30;5.6.2.1;3.6.4.12;2.3.2.23;2.7.7.6;2.7.7.31;3.6.4.-;5.6.2.3", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0034644 cellular response to UV;GO:0042276 error-prone translesion synthesis;GO:0006281 DNA repair;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2U3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y2U5-1", "uniprot_id": "A0A8V0Y2U5_CHICK", "mass": 39450.0, "length": 341, "protein_name": "Syntaxin-18", "gene_name": "STX18", "organism": "Chicken", "refseq_name": "syntaxin-18 isoform X1", "refseq_ac": "XP_015141247", "gene_names_uniprotkb": "STX18", "gene_names_refseq": "STX18", "protein_names_uniprotkb": "Syntaxin-18", "protein_names_refseq": "syntaxin-18 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6811434)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015141247.1. COMPLETENESS: full length., [RefSeq]; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031201 SNARE complex", "go_biological_process": "GO:1902117 positive regulation of organelle assembly;GO:0090158 endoplasmic reticulum membrane organization;GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y2U5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4L5-1", "uniprot_id": "A0A8V0Y4L5_CHICK", "mass": 44178.0, "length": 403, "protein_name": "Diphosphomevalonate decarboxylase", "gene_name": "MVD", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MVD", "gene_names_refseq": "", "protein_names_uniprotkb": "Diphosphomevalonate decarboxylase; 4.1.1.33", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-446199); (R-GGA-9969896)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.1.1.33", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0030544 Hsp70 protein binding;GO:0004163 diphosphomevalonate decarboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y300-1", "uniprot_id": "A0A8V0Y300_CHICK", "mass": 79969.0, "length": 700, "protein_name": "Double-strand break repair protein", "gene_name": "MRE11", "organism": "Chicken", "refseq_name": "double-strand break repair protein MRE11", "refseq_ac": "NP_001384815", "gene_names_uniprotkb": "MRE11", "gene_names_refseq": "MRE11A; MRE11", "protein_names_uniprotkb": "Double-strand break repair protein", "protein_names_refseq": "MRE11 homolog A, double strand break repair nuclease; MRE11 meiotic recombination 11 homolog A; double-strand break repair protein MRE11", "tax_id": 9031, "disease": "", "pathway": " (gga:395555); (R-GGA-1834949); (R-GGA-2559586); (R-GGA-5685938); (R-GGA-5685939); (R-GGA-5685942); (R-GGA-5693537); (R-GGA-5693548); (R-GGA-5693565); (R-GGA-5693568); (R-GGA-5693571); (R-GGA-5693579); (R-GGA-5693607); (R-GGA-5693616); (R-GGA-69473)", "pathway_count": 15, "publication_count": 2, "publication_id_list": "27311583;27814490", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267661.27938.1, SRR13267655.191340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000027.1. On Dec 3, 2021 this sequence version replaced XP_015135395.2., [RefSeq]; Although Mre11 is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines., [RefSeq, PubMed]; Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 nuclease activity is likely to remove the DNA lesions. Erratum:[Mol Cell. 2016 Dec 1;64(5):1010. doi: 10.1016/j.molcel.2016.11.028. PMID: 27912094], [RefSeq, PubMed]; Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016605 PML body;GO:0035861 site of double-strand break;GO:0005657 replication fork;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8V0Y300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y318-1", "uniprot_id": "A0A8V0Y318_CHICK", "mass": 42194.0, "length": 374, "protein_name": "Ferrochelatase", "gene_name": "FECH", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FECH", "gene_names_refseq": "", "protein_names_uniprotkb": "Ferrochelatase; 4.98.1.1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-189451); (R-GGA-9837999)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the ferrous insertion into protoporphyrin IX., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.4.1.3;3.4.21.53;1.2.4.1;1.1.1.35;1.1.1.62;1.1.1.239;1.1.1.178;1.1.1.53;1.1.1.159;1.3.8.1;1.3.8.5;2.3.1.9;3.6.4.10;5.3.3.21;4.98.1.1;4.2.1.2;2.3.3.10;2.7.1.23;5.3.3.8;5.6.2.3;1.2.4.2;3.5.3.1;6.4.1.3;2.3.1.-;7.1.2.2;1.2.1.3;1.1.1.37;2.7.11.-;6.1.1.5;5.6.1.7", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0030350 iron-responsive element binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0046501 protoporphyrinogen IX metabolic process;GO:0006784 heme A biosynthetic process;GO:0006785 heme B biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y318-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y323-1", "uniprot_id": "A0A8V0Y323_CHICK", "mass": 152142.0, "length": 1394, "protein_name": "Uromodulin like 1", "gene_name": "UMODL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "UMODL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Uromodulin like 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030414 peptidase inhibitor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005576 extracellular region;GO:0071944 cell periphery", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y323-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y326-1", "uniprot_id": "A0A8V0Y326_CHICK", "mass": 29922.0, "length": 285, "protein_name": "Pyrroline-5-carboxylate reductase", "gene_name": "PYCRL", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PYCRL", "gene_names_refseq": "", "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase; 1.5.1.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8964539)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.5.1.2", "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0055129 L-proline biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y357-1", "uniprot_id": "A0A8V0Y357_CHICK", "mass": 136567.0, "length": 1251, "protein_name": "Nidogen 1", "gene_name": "NID1", "organism": "Chicken", "refseq_name": "nidogen-1 isoform X1", "refseq_ac": "XP_040524442", "gene_names_uniprotkb": "NID1", "gene_names_refseq": "NID1", "protein_names_uniprotkb": "Nidogen 1", "protein_names_refseq": "nidogen-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052575.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005518 collagen binding;GO:0043394 proteoglycan binding;GO:0043237 laminin-1 binding", "go_cellular_component": "GO:0005604 basement membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y357-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7Y3-1", "uniprot_id": "A0A8V0Y7Y3_CHICK", "mass": 130345.0, "length": 1186, "protein_name": "Tyrosine-protein kinase", "gene_name": "ABL2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ABL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395410); (R-GGA-9013149); (R-GGA-9013423)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.12.2;2.7.11.1;2.7.10.2;2.7.10.1;2.7.12.1;2.7.11.23;3.1.4.4;3.6.5.2;2.7.11.13;2.7.10.4", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0001784 phosphotyrosine residue binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0030155 regulation of cell adhesion;GO:2000145 regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7Y3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3H5-1", "uniprot_id": "A0A8V0Y3H5_CHICK", "mass": 35311.0, "length": 314, "protein_name": "Melanocyte-stimulating hormone receptor", "gene_name": "MC1R", "organism": "Chicken", "refseq_name": "melanocyte-stimulating hormone receptor", "refseq_ac": "NP_001026633", "gene_names_uniprotkb": "MC1R", "gene_names_refseq": "MC1R", "protein_names_uniprotkb": "Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1", "protein_names_refseq": "MC1-R; MSH-R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocortin receptor 1; melanocyte-stimulating hormone receptor; mutant melanocortin 1 receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:427562); (R-GGA-375276); (R-GGA-418555)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20460655;21161779;24795300;24830563;28699279;29316344", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: KF379749.1, HQ699517.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Dec 14, 2021 this sequence version replaced NP_001026633.1., [RefSeq]; Exonic variants within the melanocortin 1 receptor (MC1R) gene are useful in distinguishing Black Silky, White Leghorn and Golden duckwing Araucana chicken., [RefSeq, PubMed]; G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein. Upon activation, MC1R couples with the G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway. This activation promotes melanogenesis, resulting in the production of eumelanin (black/brown) and pheomelanin (red/yellow) in melanocytes. MC1R interacts with G protein-coupled receptor opsin 3/OPN3, which couples to G(i) proteins and inhibits the alpha-MSH-induced cAMP response, thereby reducing melanin synthesis. Binding to Agouti/ASP precludes alpha-MSH-induced signaling, thereby downregulating melanogenesis. Additionally, interaction with MGRN1 displaces the G(s) protein, further suppressing MC1R signaling., [UniProtKB, UniProtKB, UniProtKB]; The co-segregation of plumage coloration and sequence polymorphism in TYR and MC1R genes were investigated using an intercross between black and white plumage color types of the Dongxiang blue-shelled chicken., [RefSeq, PubMed]; The ratio of the black and yellow phenotypes in the F1 offspring of the Chinese commercial line LA self-mating cross (LA x LA) is about 3:1 and in the F1 offspring of a test-cross with the yellow Line B (LB; Fig. 1b), the ratio is about 1:1, indicating that black is a dominant monogenic trait and that LA birds carry a heterozygous genotype., [RefSeq, PubMed]; The results indicate that there is abundant polymorphism in the MC1R gene, especially in Hebei chicken, which was associated with its rich plumage colour diversity., [RefSeq, PubMed]; There is a significant correlation between MC1R polymorphism and the presence of different alleles at the E locus. All but one of the populations carrying the E*E or E*R alleles had the G274A polymorphism., [RefSeq, PubMed]; These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0004978 corticotropin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032720 negative regulation of tumor necrosis factor production;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8V0Y3H5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3H9-1", "uniprot_id": "A0A8V0Y3H9_CHICK", "mass": 34747.0, "length": 302, "protein_name": "Serine/threonine-protein phosphatase", "gene_name": "PPP2CB", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PPP2CB", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase; 3.1.3.16", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-141430); (R-GGA-141444); (R-GGA-195253); (R-GGA-196299); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-389356); (R-GGA-389513); (R-GGA-5663220); (R-GGA-9648025); (R-GGA-975957); (R-GGA-9860927)", "pathway_count": 12, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.4.-;3.6.4.12;3.1.3.67;3.1.3.27;3.4.22.49;2.7.11.26;3.1.-.-;2.7.11.21;4.2.99.18;3.1.3.53;2.7.11.1;3.6.4.13;3.6.5.2", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3H9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3J1-1", "uniprot_id": "A0A8V0Y3J1_CHICK", "mass": 36600.0, "length": 337, "protein_name": "C5a anaphylatoxin chemotactic receptor 1", "gene_name": "C5AR1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "C5AR1", "gene_names_refseq": "", "protein_names_uniprotkb": "C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004875 complement receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3J1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3J7-1", "uniprot_id": "A0A8V0Y3J7_CHICK", "mass": 52547.0, "length": 484, "protein_name": "Protein BANP", "gene_name": "BANP", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BANP", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein BANP", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9766229)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3J7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3L3-1", "uniprot_id": "A0A8V0Y3L3_CHICK", "mass": 26351.0, "length": 238, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "SOD3", "organism": "Chicken", "refseq_name": "extracellular superoxide dismutase [Cu-Zn]", "refseq_ac": "XP_040555241", "gene_names_uniprotkb": "SOD3", "gene_names_refseq": "SOD3", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1", "protein_names_refseq": "extracellular superoxide dismutase [Cu-Zn]", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3299685)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB, UniProtKB]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.15.1.1;1.8.-.-", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005615 extracellular space", "go_biological_process": "GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3L3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3L8-1", "uniprot_id": "A0A8V0Y3L8_CHICK", "mass": 212781.0, "length": 1870, "protein_name": "Centrosomal protein 295", "gene_name": "CEP295", "organism": "Chicken", "refseq_name": "centrosomal protein of 295 kDa isoform X1", "refseq_ac": "XP_004938927", "gene_names_uniprotkb": "CEP295", "gene_names_refseq": "CEP295", "protein_names_uniprotkb": "Centrosomal protein 295", "protein_names_refseq": "centrosomal protein of 295 kDa isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:419003)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004938927.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005814 centriole", "go_biological_process": "GO:0046599 regulation of centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3L8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y8E0-1", "uniprot_id": "A0A8V0Y8E0_CHICK", "mass": 72307.0, "length": 655, "protein_name": "Anion exchange transporter", "gene_name": "SLC26A7", "organism": "Chicken", "refseq_name": "anion exchange transporter isoform X3", "refseq_ac": "XP_046793846", "gene_names_uniprotkb": "SLC26A7", "gene_names_refseq": "SLC26A7", "protein_names_uniprotkb": "Anion exchange transporter; Solute carrier family 26 member 7", "protein_names_refseq": "anion exchange transporter isoform X3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-427601)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.6.1.6", "go_molecular_function": "GO:0005254 chloride channel activity;GO:0140900 chloride:bicarbonate antiporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0055038 recycling endosome membrane;GO:0016328 lateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:0015705 iodide transport;GO:1902358 sulfate transmembrane transport;GO:1905039 carboxylic acid transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y8E0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3T6-1", "uniprot_id": "A0A8V0Y3T6_CHICK", "mass": 36353.0, "length": 313, "protein_name": "TBC1 domain family member 7", "gene_name": "TBC1D7", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TBC1D7", "gene_names_refseq": "", "protein_names_uniprotkb": "TBC1 domain family member 7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8854214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0062078 TSC1-TSC2 complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0031410 cytoplasmic vesicle;GO:0033596 TSC1-TSC2 complex;GO:0036064 ciliary basal body", "go_biological_process": "GO:0032007 negative regulation of TOR signaling;GO:1902018 negative regulation of cilium assembly;GO:0031398 positive regulation of protein ubiquitination;GO:0070848 response to growth factor;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3T6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3T8-1", "uniprot_id": "A0A8V0Y3T8_CHICK", "mass": 67113.0, "length": 589, "protein_name": "Phospholipase B domain containing 1", "gene_name": "PLBD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PLBD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipase B domain containing 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1482788); (R-GGA-1482839); (R-GGA-1482922); (R-GGA-1483115)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004620 phospholipase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0016042 lipid catabolic process;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3V6-1", "uniprot_id": "A0A8V0Y3V6_CHICK", "mass": 104590.0, "length": 934, "protein_name": "Receptor tyrosine kinase like orphan receptor 2", "gene_name": "ROR2", "organism": "Chicken", "refseq_name": "tyrosine-protein kinase transmembrane receptor ROR2 precursor", "refseq_ac": "NP_001074185", "gene_names_uniprotkb": "ROR2", "gene_names_refseq": "ROR2", "protein_names_uniprotkb": "Receptor tyrosine kinase like orphan receptor 2", "protein_names_refseq": "tyrosine-protein kinase transmembrane receptor ROR2 precursor; tyrosine-protein kinase transmembrane receptor ROR2", "tax_id": 9031, "disease": "", "pathway": " (gga:769516); (R-GGA-5140745)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17061261", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF017720.1, SRR13267652.17772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03579564 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000094.1. On Sep 23, 2021 this sequence version replaced NP_001074185.1., [RefSeq]; Overexpression of Ror2 mutants led to a disturbance of growth plate architecture and a severe block of chondrocyte differentiation, demonstrating the functional importance of Ror2 in skeletogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0017147 Wnt-protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0031435 mitogen-activated protein kinase kinase kinase binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030335 positive regulation of cell migration;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8V0Y3V6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3X8-1", "uniprot_id": "A0A8V0Y3X8_CHICK", "mass": 48198.0, "length": 425, "protein_name": "WD repeat domain 4", "gene_name": "WDR4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "WDR4", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat domain 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:418540)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex;GO:0106143 tRNA (m7G46) methyltransferase complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0006974 DNA damage response;GO:0106004 tRNA (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3X8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y864-1", "uniprot_id": "A0A8V0Y864_CHICK", "mass": 58270.0, "length": 536, "protein_name": "protein-serine/threonine phosphatase", "gene_name": "PPM1G", "organism": "Chicken", "refseq_name": "protein phosphatase 1G isoform X2", "refseq_ac": "XP_046770867", "gene_names_uniprotkb": "PPM1G", "gene_names_refseq": "PPM1G", "protein_names_uniprotkb": "protein-serine/threonine phosphatase; 3.1.3.16", "protein_names_refseq": "protein phosphatase 1G isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052575.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y864-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y3Y8-1", "uniprot_id": "A0A8V0Y3Y8_CHICK", "mass": 67982.0, "length": 608, "protein_name": "Cryptochrome-1", "gene_name": "CRY1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CRY1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cryptochrome-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0071949 FAD binding;GO:0003690 double-stranded DNA binding;GO:0016922 nuclear receptor binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097381 photoreceptor disc membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0032922 circadian regulation of gene expression;GO:0043153 entrainment of circadian clock by photoperiod", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y3Y8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y409-1", "uniprot_id": "A0A8V0Y409_CHICK", "mass": 46254.0, "length": 423, "protein_name": "D(1B) dopamine receptor", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "D(1B) dopamine receptor; 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2.7.11.1; PRP4 pre-mRNA-processing factor 4 homolog", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0000776 kinetochore;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0046827 positive regulation of protein export from nucleus;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint;GO:0035332 positive regulation of hippo signaling;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y457-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y464-1", "uniprot_id": "A0A8V0Y464_CHICK", "mass": 135045.0, "length": 1210, "protein_name": "Transcription elongation factor SPT5", "gene_name": "SUPT5H", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "SUPT5H", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription elongation factor SPT5; DRB sensitivity-inducing factor large subunit; Transcription elongation factor spt5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0032044 DSIF complex;GO:0005634 nucleus", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016239 positive regulation of macroautophagy;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y464-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y491-1", "uniprot_id": "A0A8V0Y491_CHICK", "mass": 104396.0, "length": 929, "protein_name": "Glutamate receptor", "gene_name": "GRID2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GRID2", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. In the presence of neurexins and cerebellins, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel activity can be triggered by GRM1 in Purkinje cells., [UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. 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This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_422154.3. 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"2.4.1.186;2.7.11.24;1.11.1.24;2.3.3.8;3.2.1.31;4.1.2.13;3.4.22.52;3.6.4.13;3.4.14.1;2.3.2.5;5.3.1.9;3.4.22.1;3.4.22.42;2.3.2.27;2.7.1.1;3.3.2.6;4.2.99.18;5.6.2.4;3.6.4.6;4.1.2.4;3.4.24.35;5.2.1.8;3.2.1.23;2.4.1.1;5.4.2.11;5.4.2.4;3.5.4.5;2.7.1.40;1.1.1.42;2.4.1.25;3.2.1.33;3.1.1.47;2.7.1.11;1.11.1.6;1.13.11.34;3.4.19.1;3.4.23.34;5.3.2.1;5.3.3.12;4.2.1.24;3.6.1.6;3.5.4.6;3.1.6.14;5.4.2.2;2.7.4.6;1.16.3.1;3.4.23.5;3.6.5.-;3.5.1.23", "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0005518 collagen binding;GO:0043394 proteoglycan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030855 epithelial cell differentiation;GO:0046718 symbiont entry into host cell;GO:0030574 collagen catabolic process;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 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"publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.1;2.7.11.25;2.7.11.21;2.7.12.2;2.7.11.13;2.7.11.17;2.7.11.24;2.7.11.22;2.7.10.2;2.7.11.12;2.7.12.1;2.7.11.39;2.7.11.38;2.7.11.23;2.7.11.26;2.7.1.150;2.1.1.-;2.7.11.31;2.7.1.153;2.7.1.137;2.7.1.154;2.7.11.11", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4L8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4N7-1", "uniprot_id": "A0A8V0Y4N7_CHICK", "mass": 13448.0, "length": 120, "protein_name": "Melanocortin-2 receptor accessory protein", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Melanocortin-2 receptor accessory protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4Q3-1", "uniprot_id": "A0A8V0Y4Q3_CHICK", "mass": 34094.0, "length": 303, "protein_name": "GTP-binding protein", "gene_name": "RRAD", "organism": "Chicken", "refseq_name": "GTP-binding protein RAD", "refseq_ac": "NP_001264535", "gene_names_uniprotkb": "RRAD", "gene_names_refseq": "RRAD; ZGC:63471", "protein_names_uniprotkb": "GTP-binding protein", "protein_names_refseq": "GTP-binding protein RAD; Ras-related associated with diabetes", "tax_id": 9031, "disease": "", "pathway": " (gga:415790)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX950258.2, BX934073.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Dec 3, 2021 this sequence version replaced NP_001264535.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains to make the sequence consistent with the transcript data. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4Q3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4S1-1", "uniprot_id": "A0A8V0Y4S1_CHICK", "mass": 30630.0, "length": 271, "protein_name": "UBC core domain-containing protein", "gene_name": "UBE2R2L", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "UBE2R2L", "gene_names_refseq": "", "protein_names_uniprotkb": "UBC core domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:427134)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0003676 nucleic acid binding;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4S1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4U4-1", "uniprot_id": "A0A8V0Y4U4_CHICK", "mass": 26444.0, "length": 234, "protein_name": "Dual specificity phosphatase 22", "gene_name": "DUSP22", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "DUSP22", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity phosphatase 22", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420887)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.67;3.1.3.27;3.1.3.21;3.1.3.74;3.1.3.53;3.1.3.18;3.1.3.2", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0030292 protein tyrosine kinase inhibitor activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0061851 leading edge of lamellipodium;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031941 filamentous actin;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0046330 positive regulation of JNK cascade;GO:0030336 negative regulation of cell migration;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0051895 negative regulation of focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4U4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6G9-1", "uniprot_id": "A0A8V0Y6G9_CHICK", "mass": 154370.0, "length": 1406, "protein_name": "Protein crumbs homolog 2", "gene_name": "CRB1", "organism": "Chicken", "refseq_name": "protein crumbs homolog 1 isoform X2", "refseq_ac": "XP_015145866", "gene_names_uniprotkb": "CRB1", "gene_names_refseq": "CRB1", "protein_names_uniprotkb": "Protein crumbs homolog 2; Crumbs-like protein 2", "protein_names_refseq": "protein crumbs homolog 1 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052539.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015145866.1. COMPLETENESS: full length., [RefSeq]; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005912 adherens junction;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0005886 plasma membrane", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0050877 nervous system process;GO:0007154 cell communication;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0023052 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y4X1-1", "uniprot_id": "A0A8V0Y4X1_CHICK", "mass": 64316.0, "length": 563, "protein_name": "NOP53 ribosome biogenesis factor", "gene_name": "GLTSCR2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GLTSCR2", "gene_names_refseq": "", "protein_names_uniprotkb": "NOP53 ribosome biogenesis factor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0002039 p53 binding;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:1903006 positive regulation of protein K63-linked deubiquitination;GO:1990173 protein localization to nucleoplasm;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y4X1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y516-1", "uniprot_id": "A0A8V0Y516_CHICK", "mass": 50913.0, "length": 459, "protein_name": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit", "gene_name": "PIGM", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "PIGM", "gene_names_refseq": "", "protein_names_uniprotkb": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit; 2.4.1.-; GPI mannosyltransferase I", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-162710)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) intermediate to generate 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0180041 dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y525-1", "uniprot_id": "A0A8V0Y525_CHICK", "mass": 11648.0, "length": 104, "protein_name": "Annexin", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Annexin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y525-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y574-1", "uniprot_id": "A0A8V0Y574_CHICK", "mass": 64107.0, "length": 563, "protein_name": "Fanconi anemia group C protein homolog", "gene_name": "FANCC", "organism": "Chicken", "refseq_name": "Fanconi anemia group C protein isoform X1", "refseq_ac": "XP_040511556", "gene_names_uniprotkb": "FANCC", "gene_names_refseq": "FANCC", "protein_names_uniprotkb": "Fanconi anemia group C protein homolog; Protein FACC", "protein_names_refseq": "Fanconi anemia group C protein isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427468); (R-GGA-6783310); (R-GGA-9833482)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0036297 interstrand cross-link repair;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y584-1", "uniprot_id": "A0A8V0Y584_CHICK", "mass": 121830.0, "length": 1088, "protein_name": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "gene_name": "PIGO", "organism": "Chicken", "refseq_name": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "refseq_ac": "NP_001376497", "gene_names_uniprotkb": "PIGO", "gene_names_refseq": "PIGO", "protein_names_uniprotkb": "GPI ethanolamine phosphate transferase 3, catalytic subunit; Phosphatidylinositol-glycan biosynthesis class O protein", "protein_names_refseq": "GPI ethanolamine phosphate transferase 3, catalytic subunit", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN02738224 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000087.1. On Sep 23, 2021 this sequence version replaced NP_001376497.1., [RefSeq]; Catalytic subunit of the ethanolamine phosphate transferase 3 complex that transfers an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the third alpha-1,2-linked mannose of the a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H7) and participates in the tenth step of the glycosylphosphatidylinositol-anchor biosynthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051377 mannose-ethanolamine phosphotransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y584-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5A9-1", "uniprot_id": "A0A8V0Y5A9_CHICK", "mass": 50512.0, "length": 448, "protein_name": "Glutathione S-transferase LANCL1", "gene_name": "LANCL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LANCL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutathione S-transferase LANCL1; 2.5.1.18; LanC-like protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.2.1.2;2.5.1.18;1.20.4.2;1.8.5.1;5.3.99.2", "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0031179 peptide modification;GO:1990748 cellular detoxification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5A9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5D3-1", "uniprot_id": "A0A8V0Y5D3_CHICK", "mass": 34166.0, "length": 307, "protein_name": "Nucleophosmin", "gene_name": "NPM1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NPM1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleophosmin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3899300); (R-GGA-606279); (R-GGA-6804115); (R-GGA-8869496); (R-GGA-9833482)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:0006338 chromatin remodeling;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5D3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5F4-1", "uniprot_id": "A0A8V0Y5F4_CHICK", "mass": 46114.0, "length": 406, "protein_name": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "gene_name": "PTCD2", "organism": "Chicken", "refseq_name": "pentatricopeptide repeat-containing protein 2, mitochondrial isoform X2", "refseq_ac": "XP_046791626", "gene_names_uniprotkb": "PTCD2", "gene_names_refseq": "PTCD2", "protein_names_uniprotkb": "Pentatricopeptide repeat-containing protein 2, mitochondrial", "protein_names_refseq": "pentatricopeptide repeat-containing protein 2, mitochondrial isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_059536) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006397 mRNA processing;GO:0007005 mitochondrion organization;GO:0050684 regulation of mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5F4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5G1-1", "uniprot_id": "A0A8V0Y5G1_CHICK", "mass": 59064.0, "length": 532, "protein_name": "Uridine-cytidine kinase", "gene_name": "LOC776992", "organism": "Chicken", "refseq_name": "uridine-cytidine kinase-like 1 isoform X1", "refseq_ac": "XP_025004922", "gene_names_uniprotkb": "LOC776992", "gene_names_refseq": "LOC776992", "protein_names_uniprotkb": "Uridine-cytidine kinase; 2.7.1.48", "protein_names_refseq": "uridine-cytidine kinase-like 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:776992)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; May contribute to UTP accumulation needed for blast transformation and proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.1.48", "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008655 pyrimidine-containing compound salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5G9-1", "uniprot_id": "A0A8V0Y5G9_CHICK", "mass": 48037.0, "length": 427, "protein_name": "Bone morphotic protein 6", "gene_name": "BMP6", "organism": "Chicken", "refseq_name": "bone morphogenetic protein 6", "refseq_ac": "XP_015131483", "gene_names_uniprotkb": "BMP6", "gene_names_refseq": "BMP6", "protein_names_uniprotkb": "Bone morphotic protein 6", "protein_names_refseq": "bone morphogenetic protein 6", "tax_id": 9031, "disease": "", "pathway": " (gga:420868)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007507 heart development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5G9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5J5-1", "uniprot_id": "A0A8V0Y5J5_CHICK", "mass": 117264.0, "length": 1009, "protein_name": "Anoctamin", "gene_name": "ANO4", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ANO4", "gene_names_refseq": "", "protein_names_uniprotkb": "Anoctamin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2672351)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5J5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5K4-1", "uniprot_id": "A0A8V0Y5K4_CHICK", "mass": 20392.0, "length": 179, "protein_name": "Interferon alpha", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-909733); (R-GGA-912694)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has antiviral activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5L9-1", "uniprot_id": "A0A8V0Y5L9_CHICK", "mass": 24703.0, "length": 212, "protein_name": "Interferon alpha", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-909733); (R-GGA-912694)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has antiviral activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5L9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5M6-1", "uniprot_id": "A0A8V0Y5M6_CHICK", "mass": 114112.0, "length": 1052, "protein_name": "hexokinase", "gene_name": "HK3", "organism": "Chicken", "refseq_name": "hexokinase-3 isoform X3", "refseq_ac": "XP_015149362", "gene_names_uniprotkb": "HK3", "gene_names_refseq": "HK3", "protein_names_uniprotkb": "hexokinase; 2.7.1.1", "protein_names_refseq": "hexokinase-3 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6798695); (R-GGA-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015149362.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.186;2.7.11.24;1.11.1.24;2.3.3.8;3.2.1.31;4.1.2.13;3.4.22.52;3.6.4.13;2.4.2.7;2.3.2.5;5.3.1.9;3.4.22.1;2.7.1.1;3.3.2.6;4.2.99.18;5.6.2.4;2.7.1.35;2.3.2.27;3.6.4.6;4.1.2.4;3.4.24.35;5.2.1.8;3.2.1.23;2.7.1.-;2.4.1.1;5.4.2.11;5.4.2.4;3.5.4.5;2.7.1.40;1.1.1.42;2.4.1.25;3.2.1.33;3.1.1.47;2.7.1.11;1.11.1.6;1.13.11.34;3.4.19.1;5.3.2.1;5.3.3.12;4.2.1.24;3.6.1.6;3.5.4.6;3.1.6.14;5.4.2.2;2.7.4.6;1.16.3.1;2.7.10.2;3.4.23.5;3.6.5.-;3.5.1.23", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5M6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5M8-1", "uniprot_id": "A0A8V0Y5M8_CHICK", "mass": 26263.0, "length": 250, "protein_name": "Avidin", "gene_name": "AVD", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AVD", "gene_names_refseq": "", "protein_names_uniprotkb": "Avidin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Forms a strong non-covalent specific complex with biotin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0009374 biotin binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5M8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5N7-1", "uniprot_id": "A0A8V0Y5N7_CHICK", "mass": 36621.0, "length": 327, "protein_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase", "gene_name": "BST1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "BST1", "gene_names_refseq": "", "protein_names_uniprotkb": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase; 3.2.2.6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422828); (R-GGA-163125); (R-GGA-196807); (R-GGA-6798695)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.2.1.3;7.6.2.1;3.6.5.2;2.4.2.31;3.1.4.50;3.2.2.6;3.1.3.48;3.1.4.4;3.4.11.9;1.14.14.18;3.1.3.1;2.7.11.1;2.3.1.51;3.4.21.73;1.14.19.17;5.2.1.-", "go_molecular_function": "GO:0016740 transferase activity;GO:0016849 phosphorus-oxygen lyase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001931 uropod;GO:0016020 membrane", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0030890 positive regulation of B cell proliferation;GO:0050727 regulation of inflammatory response;GO:0001952 regulation of cell-matrix adhesion;GO:0050848 regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5N7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5Q0-1", "uniprot_id": "A0A8V0Y5Q0_CHICK", "mass": 56048.0, "length": 507, "protein_name": "Wiskott-Aldrich syndrome protein family member", "gene_name": "WASF3L", "organism": "Chicken", "refseq_name": "wiskott-Aldrich syndrome protein family member 3 isoform X1", "refseq_ac": "XP_015134071", "gene_names_uniprotkb": "WASF3L", "gene_names_refseq": "WASF3L", "protein_names_uniprotkb": "Wiskott-Aldrich syndrome protein family member; WASP family protein member", "protein_names_refseq": "wiskott-Aldrich syndrome protein family member 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422323)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015134071.2. COMPLETENESS: full length., [RefSeq]; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0031209 SCAR complex", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5Q0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7C0-1", "uniprot_id": "A0A8V0Y7C0_CHICK", "mass": 80514.0, "length": 708, "protein_name": "F-box/LRR-repeat protein 5", "gene_name": "FBXL5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FBXL5", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/LRR-repeat protein 5; F-box and leucine-rich repeat protein 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051536 iron-sulfur cluster binding;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7C0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5U6-1", "uniprot_id": "A0A8V0Y5U6_CHICK", "mass": 56892.0, "length": 506, "protein_name": "MARVEL domain containing 2", "gene_name": "MARVELD2", "organism": "Chicken", "refseq_name": "MARVEL domain-containing protein 2", "refseq_ac": "XP_046793188", "gene_names_uniprotkb": "MARVELD2", "gene_names_refseq": "MARVELD2", "protein_names_uniprotkb": "MARVEL domain containing 2", "protein_names_refseq": "MARVEL domain-containing protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:427393)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_059536) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0043220 Schmidt-Lanterman incisure", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5U6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y5Y2-1", "uniprot_id": "A0A8V0Y5Y2_CHICK", "mass": 74650.0, "length": 656, "protein_name": "Pseudouridylate synthase 7 homolog", "gene_name": "PUS7", "organism": "Chicken", "refseq_name": "pseudouridylate synthase 7 homolog isoform X2", "refseq_ac": "XP_015131206", "gene_names_uniprotkb": "PUS7", "gene_names_refseq": "PUS7", "protein_names_uniprotkb": "Pseudouridylate synthase 7 homolog", "protein_names_refseq": "pseudouridylate synthase 7 homolog isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:417709)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "5.4.99.12;5.4.99.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0009982 pseudouridine synthase activity;GO:0160150 tRNA pseudouridine(13) synthase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:1902036 regulation of hematopoietic stem cell differentiation;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y5Y2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y608-1", "uniprot_id": "A0A8V0Y608_CHICK", "mass": 54791.0, "length": 479, "protein_name": "GDP-fucose protein O-fucosyltransferase 2", "gene_name": "POFUT2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "POFUT2", "gene_names_refseq": "", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 2; 2.4.1.221; Peptide-O-fucosyltransferase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5173214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.4.1.221;2.4.1.-;3.4.24.82", "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006004 fucose metabolic process;GO:1903334 positive regulation of protein folding;GO:0051046 regulation of secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y608-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y651-1", "uniprot_id": "A0A8V0Y651_CHICK", "mass": 88373.0, "length": 793, "protein_name": "Actin filament-associated protein 1-like 1", "gene_name": "AFAP1L1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AFAP1L1", "gene_names_refseq": "", "protein_names_uniprotkb": "Actin filament-associated protein 1-like 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in podosome and invadosome formation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0002102 podosome;GO:0042995 cell projection;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y665-1", "uniprot_id": "A0A8V0Y665_CHICK", "mass": 96246.0, "length": 882, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 5", "gene_name": "ADAMTS5", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ADAMTS5", "gene_names_refseq": "", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 5; ADMP-2; Aggrecanase-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:427971); (R-GGA-1474228); (R-GGA-5173214)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0007520 myoblast fusion;GO:0003203 endocardial cushion morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y665-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y8J0-1", "uniprot_id": "A0A8V0Y8J0_CHICK", "mass": 98247.0, "length": 875, "protein_name": "Phosphodiesterase", "gene_name": "PDE8B", "organism": "Chicken", "refseq_name": "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2", "refseq_ac": "XP_004937386", "gene_names_uniprotkb": "PDE8B", "gene_names_refseq": "PDE8B", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-418555)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004937386.1. COMPLETENESS: full length., [RefSeq]; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.4.-;3.1.4.53", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y8J0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6A4-1", "uniprot_id": "A0A8V0Y6A4_CHICK", "mass": 54426.0, "length": 488, "protein_name": "vesicle-fusing ATPase", "gene_name": "VPS4B", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "VPS4B", "gene_names_refseq": "", "protein_names_uniprotkb": "vesicle-fusing ATPase; 3.6.4.6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-917729)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.6.4.6", "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005813 centrosome", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:1904903 ESCRT III complex disassembly;GO:0061738 late endosomal microautophagy;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6A4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6C9-1", "uniprot_id": "A0A8V0Y6C9_CHICK", "mass": 64188.0, "length": 580, "protein_name": "Cystathionine beta-synthase", "gene_name": "CBS", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CBS", "gene_names_refseq": "", "protein_names_uniprotkb": "Cystathionine beta-synthase; 4.2.1.22", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:418545)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "4.2.1.22", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042262 DNA protection;GO:0043418 homocysteine catabolic process;GO:0006535 cysteine biosynthetic process from serine;GO:0006565 L-serine catabolic process;GO:0019343 cysteine biosynthetic process via cystathionine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6C9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6F1-1", "uniprot_id": "A0A8V0Y6F1_CHICK", "mass": 25959.0, "length": 238, "protein_name": "SOSS complex subunit B2", "gene_name": "NABP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NABP1", "gene_names_refseq": "", "protein_names_uniprotkb": "SOSS complex subunit B2; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6807505)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region;GO:0070876 SOSS complex", "go_biological_process": "GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6F1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6G1-1", "uniprot_id": "A0A8V0Y6G1_CHICK", "mass": 85482.0, "length": 749, "protein_name": "Kinesin-like protein", "gene_name": "KIF3C", "organism": "Chicken", "refseq_name": "kinesin-like protein KIF3C", "refseq_ac": "XP_426988", "gene_names_uniprotkb": "KIF3C", "gene_names_refseq": "KIF3C", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF3C", "tax_id": 9031, "disease": "", "pathway": " (gga:429432); (R-GGA-5620924); (R-GGA-6811434); (R-GGA-983189)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_426988.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0060271 cilium assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6G1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6H7-1", "uniprot_id": "A0A8V0Y6H7_CHICK", "mass": 51876.0, "length": 477, "protein_name": "Probable imidazolonepropionase", "gene_name": "AMDHD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "AMDHD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable imidazolonepropionase; 3.5.2.7; Amidohydrolase domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:417917); (R-GGA-70921)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.5.2.7", "go_molecular_function": "GO:0046872 metal ion binding;GO:0050480 imidazolonepropionase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6H7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6R0-1", "uniprot_id": "A0A8V0Y6R0_CHICK", "mass": 279029.0, "length": 2433, "protein_name": "GTPase, very large interferon inducible pseudo 1", "gene_name": "GVINP1", "organism": "Chicken", "refseq_name": "interferon-induced very large GTPase 1", "refseq_ac": "XP_015140713", "gene_names_uniprotkb": "GVINP1", "gene_names_refseq": "GVINP1", "protein_names_uniprotkb": "GTPase, very large interferon inducible pseudo 1", "protein_names_refseq": "interferon-induced very large GTPase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:428660)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015140713.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6R0-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6T8-1", "uniprot_id": "A0A8V0Y6T8_CHICK", "mass": 60324.0, "length": 531, "protein_name": "L-gulonolactone oxidase", "gene_name": "LOC770996", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC770996", "gene_names_refseq": "", "protein_names_uniprotkb": "L-gulonolactone oxidase; 1.1.3.8; LGO", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "1.1.3.8", "go_molecular_function": "GO:0003723 RNA binding;GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0003885 D-arabinono-1,4-lactone oxidase activity;GO:0050105 L-gulonolactone oxidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0019853 L-ascorbic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6T8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y6Z6-1", "uniprot_id": "A0A8V0Y6Z6_CHICK", "mass": 44966.0, "length": 389, "protein_name": "V-type proton ATPase subunit C", "gene_name": "ATP6V1C1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ATP6V1C1", "gene_names_refseq": "", "protein_names_uniprotkb": "V-type proton ATPase subunit C", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1222556); (R-GGA-77387); (R-GGA-917977); (R-GGA-9639288)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180 proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y6Z6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y717-1", "uniprot_id": "A0A8V0Y717_CHICK", "mass": 35964.0, "length": 331, "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "UTS2RL", "organism": "Chicken", "refseq_name": "urotensin-2 receptor", "refseq_ac": "XP_004937802", "gene_names_uniprotkb": "UTS2RL", "gene_names_refseq": "UTS2RL", "protein_names_uniprotkb": "G-protein coupled receptors family 1 profile domain-containing protein", "protein_names_refseq": "urotensin-2 receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:771154)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004937802.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001604 urotensin II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y717-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y726-1", "uniprot_id": "A0A8V0Y726_CHICK", "mass": 46426.0, "length": 414, "protein_name": "Thioredoxin domain-containing protein 5", "gene_name": "TXNDC5", "organism": "Chicken", "refseq_name": "thioredoxin domain-containing protein 5 precursor", "refseq_ac": "NP_001006374", "gene_names_uniprotkb": "TXNDC5", "gene_names_refseq": "TXNDC5", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 5; 5.3.4.1; Endoplasmic reticulum resident protein 46; Thioredoxin-like protein p46", "protein_names_refseq": "thioredoxin domain containing 5 (endoplasmic reticulum); thioredoxin domain-containing protein 5 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:420867); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720757.1, HAEK01102791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000040.1. On Sep 23, 2021 this sequence version replaced NP_001006374.1., [RefSeq]; Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.1.3.16;3.1.6.4;3.4.21.4;2.3.3.8;2.7.11.13;3.2.1.31;3.4.19.9;3.4.14.1;3.1.6.8;6.3.4.21;5.3.4.1;3.6.4.6;1.11.1.27;3.2.1.51;3.2.1.-;2.7.10.2;3.2.1.23;1.6.5.5;2.7.11.24;3.4.14.2;5.3.99.3;2.4.1.1;3.1.6.14;3.5.4.4;3.5.1.26;3.2.1.52;3.2.1.17;3.1.27.-", "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y726-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y727-1", "uniprot_id": "A0A8V0Y727_CHICK", "mass": 55960.0, "length": 509, "protein_name": "Torsin 1A interacting protein 2", "gene_name": "TOR1AIP2", "organism": "Chicken", "refseq_name": "torsin-1A-interacting protein 2 isoform X2", "refseq_ac": "XP_040533977", "gene_names_uniprotkb": "TOR1AIP2", "gene_names_refseq": "TOR1AIP2", "protein_names_uniprotkb": "Torsin 1A interacting protein 2", "protein_names_refseq": "torsin-1A-interacting protein 2 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052580.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0061024 membrane organization;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y727-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y747-1", "uniprot_id": "A0A8V0Y747_CHICK", "mass": 73066.0, "length": 681, "protein_name": "TNF receptor superfamily member 11a", "gene_name": "TNFRSF11A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TNFRSF11A", "gene_names_refseq": "", "protein_names_uniprotkb": "TNF receptor superfamily member 11a", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:769909); (R-GGA-5668541); (R-GGA-5676594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005031 tumor necrosis factor receptor activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0060086 circadian temperature homeostasis;GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion;GO:0032496 response to lipopolysaccharide;GO:0046330 positive regulation of JNK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y747-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y773-1", "uniprot_id": "A0A8V0Y773_CHICK", "mass": 57260.0, "length": 514, "protein_name": "histidine--tRNA ligase", "gene_name": "HARS2", "organism": "Chicken", "refseq_name": "histidine--tRNA ligase, cytoplasmic", "refseq_ac": "XP_001231932", "gene_names_uniprotkb": "HARS2", "gene_names_refseq": "HARS2", "protein_names_uniprotkb": "histidine--tRNA ligase; 6.1.1.21", "protein_names_refseq": "histidine--tRNA ligase, cytoplasmic", "tax_id": 9031, "disease": "", "pathway": " (gga:768802)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_001231932.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "6.1.1.21", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006427 histidyl-tRNA aminoacylation;GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y789-1", "uniprot_id": "A0A8V0Y789_CHICK", "mass": 95857.0, "length": 851, "protein_name": "Non-lysosomal glucosylceramidase", "gene_name": "GBA2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "GBA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Non-lysosomal glucosylceramidase; 3.2.1.45; NLGase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9840310)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.45", "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0046527 glucosyltransferase activity;GO:0004336 galactosylceramidase activity;GO:0050295 steryl-beta-glucosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0008203 cholesterol metabolic process;GO:0005975 carbohydrate metabolic process;GO:0007417 central nervous system development;GO:0009247 glycolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y789-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y793-1", "uniprot_id": "A0A8V0Y793_CHICK", "mass": 42501.0, "length": 380, "protein_name": "LIM homeobox transcription factor 1-alpha", "gene_name": "LMX1A", "organism": "Chicken", "refseq_name": "LIM homeobox transcription factor 1-alpha", "refseq_ac": "NP_001244317", "gene_names_uniprotkb": "LMX1A", "gene_names_refseq": "LMX1A", "protein_names_uniprotkb": "LIM homeobox transcription factor 1-alpha; LIM/homeobox protein LMX1A", "protein_names_refseq": "LIM homeobox transcription factor 1-alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:777133)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JAENSK010000237.1. On Sep 23, 2021 this sequence version replaced NP_001244317.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0050808 synapse organization;GO:0030182 neuron differentiation;GO:1904948 midbrain dopaminergic neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y793-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y794-1", "uniprot_id": "A0A8V0Y794_CHICK", "mass": 46731.0, "length": 417, "protein_name": "Pro-neuregulin-3, membrane-bound isoform", "gene_name": "NRG3", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "NRG3", "gene_names_refseq": "", "protein_names_uniprotkb": "Pro-neuregulin-3, membrane-bound isoform", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1227986); (R-GGA-1236394); (R-GGA-1250196); (R-GGA-1250342); (R-GGA-1250347); (R-GGA-1257604); (R-GGA-1963640); (R-GGA-1963642); (R-GGA-5673001); (R-GGA-6785631); (R-GGA-6811558); (R-GGA-8863795)", "pathway_count": 12, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008083 growth factor activity;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007416 synapse assembly;GO:0050804 modulation of chemical synaptic transmission;GO:0048513 animal organ development;GO:0038130 ERBB4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y794-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7B7-1", "uniprot_id": "A0A8V0Y7B7_CHICK", "mass": 83670.0, "length": 724, "protein_name": "Protein Hook homolog 3", "gene_name": "HOOK3", "organism": "Chicken", "refseq_name": "protein Hook homolog 3 isoform X1", "refseq_ac": "XP_003643087", "gene_names_uniprotkb": "HOOK3", "gene_names_refseq": "HOOK3", "protein_names_uniprotkb": "Protein Hook homolog 3", "protein_names_refseq": "protein Hook homolog 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427297)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_003643087.1. COMPLETENESS: full length., [RefSeq]; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0034452 dynactin binding;GO:0051959 dynein light intermediate chain binding;GO:0045503 dynein light chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030897 HOPS complex;GO:0005813 centrosome;GO:0005874 microtubule;GO:0070695 FHF complex", "go_biological_process": "GO:0030705 cytoskeleton-dependent intracellular transport;GO:0031122 cytoplasmic microtubule organization;GO:0015031 protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7B7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7A6-1", "uniprot_id": "A0A8V0Y7A6_CHICK", "mass": 28205.0, "length": 251, "protein_name": "Proopiomelanocortin", "gene_name": "POMC", "organism": "Chicken", "refseq_name": "pro-opiomelanocortin precursor", "refseq_ac": "NP_001385046", "gene_names_uniprotkb": "POMC", "gene_names_refseq": "ACTH; POMC", "protein_names_uniprotkb": "Proopiomelanocortin", "protein_names_refseq": "adrenocorticotropic hormone; pro-opiomelanocortin a-1; pro-opiomelanocortin a-2; pro-opiomelanocortin b-1; pro-opiomelanocortin b-2; pro-opiomelanocortin precursor; proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-111885); (R-GGA-193048); (R-GGA-202040); (R-GGA-209952); (R-GGA-375276); (R-GGA-418555); (R-GGA-418594)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "18809870;21177457;22399312;31635770;32475422", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01111525.1, HAEK01001718.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051, SAMN02738216 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HAEK01001718.1, BI389637.1, BX260696.2 and BX540524.3. On Dec 8, 2021 this sequence version replaced XP_015140589.2., [RefSeq]; Association analysis on the polymorphisms of the POMC gene and production traits showed that the c. C495T mutation in the POMC gene was linked to the pelvis breadth at 4 weeks of age, body weight at 2 weeks of age and chest depth at 12 weeks of age, [RefSeq, PubMed]; Endogenous opiate., [UniProtKB, UniProtKB]; POMC gene expression, polymorphism, and the association with reproduction traits in chickens., [RefSeq, PubMed]; POMC genes may play important roles and could be candidate loci for production traits such as feed conversion and body weight in commercial broiler breeding stock. Erratum:[Poult Sci. 2008 Oct;87(10):doi:10.3382/ps.2008-87-12-2689], [RefSeq, PubMed]; The present study suggests that parathyroid hormone-related peptide may act directly on the anterior pituitary and may enhance adrenocorticotropic hormone (ACTH) secretion from this tissue in hens., [RefSeq, PubMed]; These results indicate the expression of the POMC gene had significant genotype effects on the reproduction traits of Zhenning yellow chickens, and that the H2H3 diplotype could be used as a potential genetic marker to improve the reproduction traits in chicken breeding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity;GO:0031781 type 3 melanocortin receptor binding;GO:0031782 type 4 melanocortin receptor binding;GO:0070996 type 1 melanocortin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0007218 neuropeptide signaling pathway;GO:0007267 cell-cell signaling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032098 regulation of appetite", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8V0Y7A6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7B2-1", "uniprot_id": "A0A8V0Y7B2_CHICK", "mass": 83164.0, "length": 748, "protein_name": "WD repeat-containing protein 91", "gene_name": "WDR91", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "WDR91", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat-containing protein 91", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0045022 early endosome to late endosome transport;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7B2-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7B5-1", "uniprot_id": "A0A8V0Y7B5_CHICK", "mass": 55943.0, "length": 507, "protein_name": "Monocarboxylate transporter 9", "gene_name": "SLC16A9", "organism": "Chicken", "refseq_name": "monocarboxylate transporter 9 isoform X1", "refseq_ac": "XP_015143618", "gene_names_uniprotkb": "SLC16A9", "gene_names_refseq": "SLC16A9", "protein_names_uniprotkb": "Monocarboxylate transporter 9; Solute carrier family 16 member 9", "protein_names_refseq": "monocarboxylate transporter 9 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052537.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015143618.2. COMPLETENESS: full length., [RefSeq]; Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Also functions as a pH-independent carnitine efflux transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1905039 carboxylic acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7B5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7C8-1", "uniprot_id": "A0A8V0Y7C8_CHICK", "mass": 131939.0, "length": 1153, "protein_name": "Alpha-mannosidase", "gene_name": "MAN2A1", "organism": "Chicken", "refseq_name": "alpha-mannosidase 2 isoform X1", "refseq_ac": "XP_003643094", "gene_names_uniprotkb": "MAN2A1", "gene_names_refseq": "MAN2A1", "protein_names_uniprotkb": "Alpha-mannosidase; 3.2.1.-", "protein_names_refseq": "alpha-mannosidase 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:415611); (R-GGA-975578)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_003643094.1. COMPLETENESS: full length., [RefSeq]; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "3.2.1.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006491 N-glycan processing;GO:0006013 mannose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7C8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7D1-1", "uniprot_id": "A0A8V0Y7D1_CHICK", "mass": 109063.0, "length": 982, "protein_name": "Anion exchange protein", "gene_name": "SLC4A9", "organism": "Chicken", "refseq_name": "anion exchange protein 4 isoform X2", "refseq_ac": "XP_015149040", "gene_names_uniprotkb": "SLC4A9", "gene_names_refseq": "SLC4A9", "protein_names_uniprotkb": "Anion exchange protein", "protein_names_refseq": "anion exchange protein 4 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:769199); (R-GGA-425381)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0008510 sodium:bicarbonate symporter activity;GO:0140892 sodium,bicarbonate:chloride antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0046541 saliva secretion;GO:0055085 transmembrane transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7D1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7E8-1", "uniprot_id": "A0A8V0Y7E8_CHICK", "mass": 143059.0, "length": 1257, "protein_name": "Apoptotic protease-activating factor 1", "gene_name": "APAF1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "APAF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Apoptotic protease-activating factor 1; APAF-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-111458); (R-GGA-111459); (R-GGA-6798695); (R-GGA-9627069)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0043531 ADP binding;GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process", "go_cellular_component": "GO:0005634 nucleus;GO:0043293 apoptosome", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7E8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7F7-1", "uniprot_id": "A0A8V0Y7F7_CHICK", "mass": 104972.0, "length": 974, "protein_name": "SRCR domain-containing protein", "gene_name": "LOC107053766", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "LOC107053766", "gene_names_refseq": "", "protein_names_uniprotkb": "SRCR domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7F7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7K4-1", "uniprot_id": "A0A8V0Y7K4_CHICK", "mass": 21149.0, "length": 199, "protein_name": "High mobility group AT-hook 2", "gene_name": "HMGA2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "HMGA2", "gene_names_refseq": "", "protein_names_uniprotkb": "High mobility group AT-hook 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2559584)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0010557 positive regulation of macromolecule biosynthetic process;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7K4-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7K8-1", "uniprot_id": "A0A8V0Y7K8_CHICK", "mass": 68121.0, "length": 598, "protein_name": "Ceramide transfer protein", "gene_name": "CERT1", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "CERT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ceramide transfer protein; Collagen type IV alpha-3-binding protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:427209)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0016301 kinase activity;GO:0097001 ceramide binding;GO:0120017 ceramide transfer activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006672 ceramide metabolic process;GO:0035621 ER to Golgi ceramide transport;GO:0120012 intermembrane sphingolipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7K8-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7L5-1", "uniprot_id": "A0A8V0Y7L5_CHICK", "mass": 30876.0, "length": 279, "protein_name": "Homeobox domain-containing protein", "gene_name": "HOXCDX1L", "organism": "Chicken", "refseq_name": "homeobox protein CDX-1", "refseq_ac": "XP_420293", "gene_names_uniprotkb": "HOXCDX1L", "gene_names_refseq": "HOXCDX1L", "protein_names_uniprotkb": "Homeobox domain-containing protein", "protein_names_refseq": "homeobox protein CDX-1", "tax_id": 9031, "disease": "", "pathway": " (gga:422317)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_420293.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0048565 digestive tract development;GO:0009948 anterior/posterior axis specification;GO:0009880 embryonic pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7L5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7R6-1", "uniprot_id": "A0A8V0Y7R6_CHICK", "mass": 40204.0, "length": 361, "protein_name": "CBY1 interacting BAR domain containing 1", "gene_name": "FAM92A", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "FAM92A", "gene_names_refseq": "", "protein_names_uniprotkb": "CBY1 interacting BAR domain containing 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:428371)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031514 motile cilium;GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0097546 ciliary base", "go_biological_process": "GO:0097749 membrane tubulation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0060271 cilium assembly;GO:0035108 limb morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7R6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7X3-1", "uniprot_id": "A0A8V0Y7X3_CHICK", "mass": 29226.0, "length": 269, "protein_name": "Mannose binding lectin 2", "gene_name": "MBL2", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "MBL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mannose binding lectin 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374267)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7X3-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7Z7-1", "uniprot_id": "A0A8V0Y7Z7_CHICK", "mass": 50744.0, "length": 454, "protein_name": "Gastric inhibitory polypeptide receptor", "gene_name": "GIPR", "organism": "Chicken", "refseq_name": "gastric inhibitory polypeptide receptor", "refseq_ac": "XP_025000272", "gene_names_uniprotkb": "GIPR", "gene_names_refseq": "GIPR", "protein_names_uniprotkb": "Gastric inhibitory polypeptide receptor", "protein_names_refseq": "gastric inhibitory polypeptide receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:100858765); (R-GGA-418555); (R-GGA-420092)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052569.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_025000272.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0016519 gastric inhibitory peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7Z7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y7Z9-1", "uniprot_id": "A0A8V0Y7Z9_CHICK", "mass": 23928.0, "length": 224, "protein_name": "Histone H5", "gene_name": "H-10", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "H-10", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0031491 nucleosome binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0000791 euchromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y7Z9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y808-1", "uniprot_id": "A0A8V0Y808_CHICK", "mass": 74073.0, "length": 677, "protein_name": "Receptor activity-modifying protein 1", "gene_name": "RBM44", "organism": "Chicken", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "RBM44", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor activity-modifying protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-418555); (R-GGA-419812)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB. Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0015026 coreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007186 G protein-coupled receptor signaling pathway;GO:0015031 protein transport;GO:0031623 receptor internalization;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y808-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y840-1", "uniprot_id": "A0A8V0Y840_CHICK", "mass": 46617.0, "length": 426, "protein_name": "Urea transporter", "gene_name": "LOC107051909", "organism": "Chicken", "refseq_name": "urea transporter 2", "refseq_ac": "XP_015132910", "gene_names_uniprotkb": "LOC107051909", "gene_names_refseq": "LOC107051909", "protein_names_uniprotkb": "Urea transporter", "protein_names_refseq": "urea transporter 2", "tax_id": 9031, "disease": "", "pathway": " (gga:107051909); (R-GGA-549127)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015132910.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "A0A8V0Y841-1", "uniprot_id": "A0A8V0Y841_CHICK", "mass": 145643.0, "length": 1307, "protein_name": "Contactin associated protein family member 4", "gene_name": "CNTNAP4", "organism": "Chicken", "refseq_name": "contactin-associated protein-like 4", "refseq_ac": "XP_046792781", "gene_names_uniprotkb": "CNTNAP4", "gene_names_refseq": "CNTNAP4", "protein_names_uniprotkb": "Contactin associated protein family member 4", "protein_names_refseq": "contactin-associated protein-like 4", "tax_id": 9031, "disease": "", "pathway": " (gga:430532)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_059536) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8V0Y841-1", "record_type": "protein" } ]