[ { "uniprot_canonical_ac": "P32836-1", "uniprot_id": "GSP2_YEAST", "mass": 24991.0, "length": 220, "protein_name": "GTP-binding nuclear protein GSP2/CNR2", "gene_name": "GSP2", "organism": "Yeast", "refseq_name": "Ran GTPase GSP2", "refseq_ac": "NP_014828", "gene_names_uniprotkb": "GSP2; CNR2", "gene_names_refseq": "CNR2; GSP2", "protein_names_uniprotkb": "GTP-binding nuclear protein GSP2/CNR2", "protein_names_refseq": "Ran GTPase GSP2", "tax_id": 559292, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (sce:YOR185C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17322287;21126336;24374639;33491328;7687541;8455603;9169874", "class_list": "", "function": "GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Not essential for cell viability., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2P1", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0000054 ribosomal subunit export from nucleus;GO:0006997 nucleus organization;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32836-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32837-1", "uniprot_id": "UGA4_YEAST", "mass": 61873.0, "length": 571, "protein_name": "GABA-specific permease", "gene_name": "UGA4", "organism": "Yeast", "refseq_name": "Uga4p", "refseq_ac": "NP_010071", "gene_names_uniprotkb": "UGA4; D1037", "gene_names_refseq": "UGA4", "protein_names_uniprotkb": "GABA-specific permease; GABA-specific transport protein", "protein_names_refseq": "Uga4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL210W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14985124;16847258;24374639;34965436;8455553;9169867", "class_list": "", "function": "Required for high-affinity, high-specificity GABA transport. Also transports putrescine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRE4", "ec_number_list": "", "go_molecular_function": "GO:0015495 gamma-aminobutyric acid:proton symporter activity;GO:0015489 putrescine transmembrane transporter activity;GO:0015185 gamma-aminobutyric acid transmembrane transporter activity", "go_cellular_component": "GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015812 gamma-aminobutyric acid transport;GO:0015847 putrescine transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32837-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32843-1", "uniprot_id": "YME2_YEAST", "mass": 96689.0, "length": 850, "protein_name": "Mitochondrial escape protein 2", "gene_name": "YME2", "organism": "Yeast", "refseq_name": "Yme2p", "refseq_ac": "NP_014031", "gene_names_uniprotkb": "YME2; PRP12; RNA12; YM9952.04C", "gene_names_refseq": "PRP12; RNA12; YME2", "protein_names_uniprotkb": "Mitochondrial escape protein 2; Protein RNA12", "protein_names_refseq": "Yme2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR302C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11737636;14562095;14562106;14576278;1557037;16850347;24374639;32597660;8514129;8649384;9169872;9933355", "class_list": "", "function": "Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0C9", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006397 mRNA processing;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32875-1", "uniprot_id": "LIPA_YEAST", "mass": 46247.0, "length": 414, "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "LIP5", "organism": "Yeast", "refseq_name": "lipoate synthase", "refseq_ac": "NP_014839", "gene_names_uniprotkb": "LIP5", "gene_names_refseq": "LIP5", "protein_names_uniprotkb": "Lipoyl synthase, mitochondrial; 2.8.1.8; LS; Lip-syn; Lipoate synthase; Lipoic acid synthase", "protein_names_refseq": "lipoate synthase", "tax_id": 559292, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)", "pathway": " (sce:YOR196C); (R-SCE-9857492)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562095;14562106;14576278;17322287;19570983;19779198;24374639;8349643;9169874", "class_list": "", "function": "Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Q5", "ec_number_list": "2.8.1.8", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016992 lipoate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009249 protein lipoylation;GO:0009107 lipoate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P32875-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32896-1", "uniprot_id": "PDC2_YEAST", "mass": 103944.0, "length": 925, "protein_name": "Protein PDC2", "gene_name": "PDC2", "organism": "Yeast", "refseq_name": "Pdc2p", "refseq_ac": "NP_010366", "gene_names_uniprotkb": "PDC2; D4451", "gene_names_refseq": "PDC2", "protein_names_uniprotkb": "Protein PDC2", "protein_names_refseq": "Pdc2p", "tax_id": 559292, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); inner ear disease (Disease Ontology:DOID:2952)", "pathway": " (sce:YDR081C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;18407956;19779198;22814378;23749301;24374639;33481703;33491328;33502312;7483840;8264540;9169867", "class_list": "", "function": "Essential for the synthesis of pyruvate decarboxylase. May be important for a high basal level of PDC gene expression or play a positive role in the autoregulation control of PDC1 and PDC5., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS68;E9PAG9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0090180 positive regulation of thiamine biosynthetic process;GO:2001172 positive regulation of glycolytic fermentation to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32903-1", "uniprot_id": "PMP1_YEAST", "mass": 4501.0, "length": 40, "protein_name": "Plasma membrane ATPase proteolipid 1", "gene_name": "PMP1", "organism": "Yeast", "refseq_name": "proteolipid ATPase", "refseq_ac": "NP_058137", "gene_names_uniprotkb": "PMP1; YCR24C-A", "gene_names_refseq": "PMP1", "protein_names_uniprotkb": "Plasma membrane ATPase proteolipid 1", "protein_names_refseq": "proteolipid ATPase", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR024C-A)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;1532582;1574125;24374639", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR35;Q76PA9", "ec_number_list": "", "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032781 positive regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P32903-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32904-1", "uniprot_id": "RM06_YEAST", "mass": 23889.0, "length": 214, "protein_name": "Large ribosomal subunit protein uL6m", "gene_name": "MRPL6", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL6m MRPL6", "refseq_ac": "NP_012017", "gene_names_uniprotkb": "MRPL6", "gene_names_refseq": "MRPL6; uL6m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL6m; 54S ribosomal protein L6, mitochondrial; YmL16", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL6m MRPL6", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR147C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12392552;14562106;14576278;24374639;24675956;25609543;33491328;8091229;8358820;9151978", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL96", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32904-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32907-1", "uniprot_id": "ATO2_YEAST", "mass": 30701.0, "length": 282, "protein_name": "Ammonia transport outward protein 2", "gene_name": "ATO2", "organism": "Yeast", "refseq_name": "putative ammonium permease ATO2", "refseq_ac": "NP_014399", "gene_names_uniprotkb": "ATO2; FUN34; N2029", "gene_names_refseq": "ATO2; FUN34", "protein_names_uniprotkb": "Ammonia transport outward protein 2", "protein_names_refseq": "putative ammonium permease ATO2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR002C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12429834;1400451;16847258;17233767;17395151;17761666;24374639;33481703;33491328;7900425;7941739;9169873", "class_list": "", "function": "Transporter protein required for ammonia export. Involved in acetate resistance., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1H8", "ec_number_list": "", "go_molecular_function": "GO:0008519 ammonium channel activity;GO:0015123 acetate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0072488 ammonium transmembrane transport;GO:0019740 nitrogen utilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P32907-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32909-1", "uniprot_id": "SMY2_YEAST", "mass": 81397.0, "length": 740, "protein_name": "Protein SMY2", "gene_name": "SMY2", "organism": "Yeast", "refseq_name": "Smy2p", "refseq_ac": "NP_009731", "gene_names_uniprotkb": "SMY2; YBR1233", "gene_names_refseq": "SMY2", "protein_names_uniprotkb": "Protein SMY2; Suppressor of MYO2-66 protein", "protein_names_refseq": "Smy2p", "tax_id": 559292, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Parkinson's disease (Disease Ontology:DOID:14330); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YBR172C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11875433;12748633;14562095;14562106;15665377;16120600;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23273919;23749301;24374639;30516470;32597660;33229814;33481703;33491328;7813418;8212898", "class_list": "", "function": "Suppressor of the MYO2 gene., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 22, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 22, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 22, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "D6VQG8", "ec_number_list": "", "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0045947 negative regulation of translational initiation;GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system;GO:0032984 protein-containing complex disassembly", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P32909-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33122-1", "uniprot_id": "TYE7_YEAST", "mass": 32689.0, "length": 291, "protein_name": "Transcription factor TYE7", "gene_name": "TYE7", "organism": "Yeast", "refseq_name": "Tye7p", "refseq_ac": "NP_014989", "gene_names_uniprotkb": "TYE7; O6233; SGC1", "gene_names_refseq": "SGC1; TYE7", "protein_names_uniprotkb": "Transcription factor TYE7; Basic-helix-loop-helix protein SGC1; Ty1-mediated expression protein 7", "protein_names_refseq": "Tye7p", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); prostate cancer (Disease Ontology:DOID:10283); sarcoma (Disease Ontology:DOID:1115); alcoholic hepatitis (Disease Ontology:DOID:12351); cardiovascular system disease (Disease Ontology:DOID:1287); alcohol use disorder (Disease Ontology:DOID:1574); nephrosis (Disease Ontology:DOID:2527); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); lipid storage disease (Disease Ontology:DOID:9455); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YOR344C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10606743;14562106;16157877;16381908;17241460;17330950;17563356;18315882;18407956;19779198;19795423;19823750;21177495;21703335;22379133;23749301;24374639;32597660;33481703;33491328;33502312;34605438;34965436;7739544;7900422;8948102;9169874", "class_list": "", "function": "Transcriptional activator of glycolytic gene expression, such as enolase genes (ENO1 and ENO2), glyceraldehyde-3-phosphate dehydrogenase gene (TDH), phosphoglycerate kinase (PGK1), phosphoglycerate mutase (PGM1), pyruvate kinase (PYK1) and triosephosphate isomerase (TPI1) genes (PubMed:10606743, PubMed:7739544). Binds DNA on E-box motifs: 5'-CANNTG-3' (PubMed:10606743). In response to adenylic nucleotide reduction, activates Ty1 mRNA transcription, possibly by controlling Ty1 antisense transcription (PubMed:22379133, PubMed:7900422). Acts as a cell cycle transcription factor (PubMed:16157877, PubMed:16381908, PubMed:18315882, PubMed:21703335). Its function may also be linked to sulfur metabolism and the cross-regulation between phosphate and sulfate metabolism (PubMed:17241460)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W340", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001216 DNA-binding transcription activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045821 positive regulation of glycolytic process;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P33122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33200-1", "uniprot_id": "PDR3_YEAST", "mass": 112571.0, "length": 976, "protein_name": "Transcription factor PDR3", "gene_name": "PDR3", "organism": "Yeast", "refseq_name": "drug-responsive transcription factor PDR3", "refseq_ac": "NP_009548", "gene_names_uniprotkb": "PDR3; YBL0323", "gene_names_refseq": "AMY2; PDR3; TPE2", "protein_names_uniprotkb": "Transcription factor PDR3; Pleiotropic drug resistance protein 3", "protein_names_refseq": "drug-responsive transcription factor PDR3", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL005W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "1441753;14562106;17322287;18407956;21177495;24374639;32597660;33481703;33491328;7813418;8078477", "class_list": "", "function": "PDR1 and PDR3 jointly control the transcription level of both SNQ2 and PDR5., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPZ5;E9P920", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071466 cellular response to xenobiotic stimulus;GO:2001040 positive regulation of cellular response to drug", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P33200-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33311-1", "uniprot_id": "MDL2_YEAST", "mass": 85137.0, "length": 773, "protein_name": "ATP-dependent permease MDL2, mitochondrial", "gene_name": "MDL2", "organism": "Yeast", "refseq_name": "ATP-binding cassette permease MDL2", "refseq_ac": "NP_015053", "gene_names_uniprotkb": "MDL2; SSH1", "gene_names_refseq": "MDL2", "protein_names_uniprotkb": "ATP-dependent permease MDL2, mitochondrial; Multidrug resistance-like protein 2", "protein_names_refseq": "ATP-binding cassette permease MDL2", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL270W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11251115;12748633;14562095;14562106;14576278;17322287;24374639;7912468;9169875", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3A0;Q08983", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015421 ABC-type oligopeptide transporter activity;GO:1904680 peptide transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0090374 oligopeptide export from mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P33311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33312-1", "uniprot_id": "RIB7_YEAST", "mass": 27116.0, "length": 244, "protein_name": "2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase", "gene_name": "RIB7", "organism": "Yeast", "refseq_name": "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase", "refseq_ac": "NP_009711", "gene_names_uniprotkb": "RIB7; YBR1203", "gene_names_refseq": "RIB7", "protein_names_uniprotkb": "2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase; 1.1.1.302; 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase; 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase; DARIPP synthase; DAROPP reductase; DARP reductase", "protein_names_refseq": "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR153W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17322287;24374639;4555411;7813418;8488729", "class_list": "", "function": "Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQE8", "ec_number_list": "1.1.1.302", "go_molecular_function": "GO:0050661 NADP binding;GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity", "go_cellular_component": "", "go_biological_process": "GO:0009231 riboflavin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P33312-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33330-1", "uniprot_id": "SERC_YEAST", "mass": 43416.0, "length": 395, "protein_name": "Phosphoserine aminotransferase", "gene_name": "SER1", "organism": "Yeast", "refseq_name": "O-phospho-L-serine:2-oxoglutarate transaminase", "refseq_ac": "NP_014827", "gene_names_uniprotkb": "SER1; ADE9; SERC", "gene_names_refseq": "ADE9; SER1", "protein_names_uniprotkb": "Phosphoserine aminotransferase; 2.6.1.52; PSAT; Phosphohydroxythreonine aminotransferase; Serine requiring protein 1", "protein_names_refseq": "O-phospho-L-serine:2-oxoglutarate transaminase", "tax_id": 559292, "disease": "PSAT deficiency (Disease Ontology:DOID:0050723); Neu-Laxova syndrome 2 (Disease Ontology:DOID:0080075)", "pathway": " (sce:YOR184W); (R-SCE-977347)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10509016;1326413;14562106;18407956;19779198;21126336;22842922;23749301;24374639;30516470;32597660;33481703;33491328;7553933;8017107;9169874", "class_list": "", "function": "Phosphoserine aminotransferase (PSAT) is a pyridoxal 5'-phosphate-dependent enzyme involved in the second step of the phosphorylated pathway of serine biosynthesis (PubMed:1326413). Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (PubMed:1326413). Plays an indirect role in purine biosynthesis (PubMed:10509016)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2P0", "ec_number_list": "2.6.1.52", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009113 purine nucleobase biosynthetic process;GO:0006564 L-serine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P33330-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33336-1", "uniprot_id": "SKN1_YEAST", "mass": 86241.0, "length": 771, "protein_name": "Beta-glucan synthesis-associated protein SKN1", "gene_name": "SKN1", "organism": "Yeast", "refseq_name": "beta-glucan synthesis-associated protein SKN1", "refseq_ac": "NP_011659", "gene_names_uniprotkb": "SKN1", "gene_names_refseq": "SKN1", "protein_names_uniprotkb": "Beta-glucan synthesis-associated protein SKN1", "protein_names_refseq": "beta-glucan synthesis-associated protein SKN1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR143W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;17287358;17563356;18407956;19684113;19779198;19795423;19823750;22106047;23749301;24374639;33481703;33491328;7929594;8321211;9169869", "class_list": "", "function": "Required for synthesis of the major beta-glucans of the yeast cell wall., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VUS3", "ec_number_list": "", "go_molecular_function": "GO:0015926 glucosidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0010507 negative regulation of autophagy;GO:0006078 (1->6)-beta-D-glucan biosynthetic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P33336-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33411-1", "uniprot_id": "PRP18_YEAST", "mass": 28377.0, "length": 251, "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "PRP18", "organism": "Yeast", "refseq_name": "mRNA splicing protein PRP18", "refseq_ac": "NP_011520", "gene_names_uniprotkb": "PRP18", "gene_names_refseq": "PRP18", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 18", "protein_names_refseq": "mRNA splicing protein PRP18", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR006W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10449419;10737784;23749301;24374639;33491328;7995524;8474454;8982874;9169869", "class_list": "", "function": "Component of the U4/U5/U6 snRNP, binding principally to the u5 snRNP. It is not absolutely required for the second step of pre-mRNA splicing at low temperatures but is required at higher temperatures. It may stabilize a particular conformation of the U5 snRNP or orient the U5 snRNP within the U4/U5/U6 snRNP or within the spliceosome., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUE3;Q02459;Q05724", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005682 U5 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0071021 U2-type post-spliceosomal complex", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P33411-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33412-1", "uniprot_id": "ECT1_YEAST", "mass": 36863.0, "length": 323, "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "ECT1", "organism": "Yeast", "refseq_name": "ethanolamine-phosphate cytidylyltransferase", "refseq_ac": "NP_011521", "gene_names_uniprotkb": "ECT1; G3856; MUQ1", "gene_names_refseq": "ECT1; MUQ1", "protein_names_uniprotkb": "Ethanolamine-phosphate cytidylyltransferase; 2.7.7.14; CTP:phosphoethanolamine cytidylyltransferase; Phosphorylethanolamine transferase", "protein_names_refseq": "ethanolamine-phosphate cytidylyltransferase", "tax_id": 559292, "disease": "hereditary spastic paraplegia 82 (Disease Ontology:DOID:0112343)", "pathway": " (sce:YGR007W); (R-SCE-1483213)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11055939;14562095;14562106;17012796;17322287;17761681;18776695;24374639;33491328;8474454;8982874;9169869", "class_list": "", "function": "Ethanolamine-phosphate cytidylyltransferase which catalyzes the second step of phosphatidylethanolamine biosynthesis. Involved in the maintenance of plasma membrane and required for proper sporulation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUE4;Q05725", "ec_number_list": "2.7.7.14", "go_molecular_function": "GO:0004306 ethanolamine-phosphate cytidylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P33412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33417-1", "uniprot_id": "IXR1_YEAST", "mass": 67856.0, "length": 597, "protein_name": "Intrastrand cross-link recognition protein", "gene_name": "IXR1", "organism": "Yeast", "refseq_name": "DNA-binding transcription repressor IXR1", "refseq_ac": "NP_012893", "gene_names_uniprotkb": "IXR1; ORD1; YKL245", "gene_names_refseq": "IXR1; ORD1", "protein_names_uniprotkb": "Intrastrand cross-link recognition protein; SSRP; Structure-specific recognition protein", "protein_names_refseq": "DNA-binding transcription repressor IXR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL032C); (R-SCE-140342); (R-SCE-163282); (R-SCE-9837999)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "14562095;18407956;19795423;19823750;21573136;22218487;24374639;32597660;33481703;33491328;8041793;8196765;8203146;8342024", "class_list": "", "function": "Binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Activate the expression of the COX5B gene., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ4", "ec_number_list": "", "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:2000819 regulation of nucleotide-excision repair;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P33417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33448-1", "uniprot_id": "TOM6_YEAST", "mass": 6408.0, "length": 61, "protein_name": "Mitochondrial import receptor subunit TOM6", "gene_name": "TOM6", "organism": "Yeast", "refseq_name": "Tom6p", "refseq_ac": "NP_014688", "gene_names_uniprotkb": "TOM6; ISP6", "gene_names_refseq": "ISP6; MOM8B; TOM6", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM6; Mitochondrial import site protein ISP6; Translocase of outer membrane 6 kDa subunit", "protein_names_refseq": "Tom6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR045W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11276259;17322287;20668160;21126336;22218487;22814378;24374639;31600774;31740857;33481703;33491328;34446444;37696957;38360717;8344244;9169874;9774667", "class_list": "", "function": "Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. TOM6 is involved in assembly and stability of the TOM complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2B1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0030150 protein import into mitochondrial matrix;GO:0070096 mitochondrial outer membrane translocase complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P33448-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33550-1", "uniprot_id": "KTR2_YEAST", "mass": 50651.0, "length": 425, "protein_name": "Probable mannosyltransferase KTR2", "gene_name": "KTR2", "organism": "Yeast", "refseq_name": "mannosyltransferase KTR2", "refseq_ac": "NP_012987", "gene_names_uniprotkb": "KTR2", "gene_names_refseq": "KTR2", "protein_names_uniprotkb": "Probable mannosyltransferase KTR2; 2.4.1.-", "protein_names_refseq": "mannosyltransferase KTR2", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR061W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "19779198;21177495;24374639;8196765;8256512", "class_list": "", "function": "Involved in N-linked glycosylation. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC2", "ec_number_list": "", "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0006493 protein O-linked glycosylation;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P33550-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33749-1", "uniprot_id": "MSN4_YEAST", "mass": 69723.0, "length": 630, "protein_name": "Zinc finger protein MSN4", "gene_name": "MSN4", "organism": "Yeast", "refseq_name": "stress-responsive transcriptional activator MSN4", "refseq_ac": "NP_012861", "gene_names_uniprotkb": "MSN4", "gene_names_refseq": "MSN4", "protein_names_uniprotkb": "Zinc finger protein MSN4; Multicopy suppressor of SNF1 protein 4", "protein_names_refseq": "stress-responsive transcriptional activator MSN4", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL062W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "12732613;15665377;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;22814378;23749301;24140345;24374639;27618436;30516470;32597660;33229814;33481703;33491328;34965436;8091862;8196765;8321194;8641288", "class_list": "", "function": "Positive transcriptional factor that acts as a component of the stress responsive system. Recognizes and binds to the stress response element (STRE) which is involved in the response to various forms of stress (heat, oxidative, osmotic, etc.). Involved in the regulation of the CTT1, DDR2, HSP12 genes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 58, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VXM5;P35726", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0070417 cellular response to cold;GO:0071469 cellular response to alkaline pH;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P33749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33750-1", "uniprot_id": "DCA13_YEAST", "mass": 56789.0, "length": 489, "protein_name": "Protein SOF1", "gene_name": "SOF1", "organism": "Yeast", "refseq_name": "rRNA-processing protein SOF1", "refseq_ac": "NP_013090", "gene_names_uniprotkb": "SOF1; L1339", "gene_names_refseq": "SOF1", "protein_names_uniprotkb": "Protein SOF1; U3 small nucleolar RNA-associated protein SOF1; U3 snoRNA-associated protein SOF1", "protein_names_refseq": "rRNA-processing protein SOF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL011W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12068309;14562106;21126336;22814378;24374639;32597660;33229814;33481703;33491328;8508778;8810043;9169871", "class_list": "", "function": "Required for ribosomal RNA processing., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VXZ1", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P33750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33759-1", "uniprot_id": "RT05_YEAST", "mass": 34883.0, "length": 307, "protein_name": "Small ribosomal subunit protein uS5m", "gene_name": "MRPS5", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein uS5m MRPS5", "refseq_ac": "NP_009810", "gene_names_uniprotkb": "MRPS5; YBR1704", "gene_names_refseq": "MRPS5; uS5m", "protein_names_uniprotkb": "Small ribosomal subunit protein uS5m; 37S ribosomal protein S5, mitochondrial", "protein_names_refseq": "mitochondrial 37S ribosomal protein uS5m MRPS5", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR251W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11278769;12392552;14562095;14562106;14576278;24374639;25609543;28154081;7813418;8256522", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQP7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P33759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33890-1", "uniprot_id": "TIR2_YEAST", "mass": 24628.0, "length": 251, "protein_name": "Cold shock-induced protein TIR2", "gene_name": "TIR2", "organism": "Yeast", "refseq_name": "putative GPI-anchored mannoprotein", "refseq_ac": "NP_014653", "gene_names_uniprotkb": "TIR2; O2553; SRP2; UND251", "gene_names_refseq": "SRP2; TIR2", "protein_names_uniprotkb": "Cold shock-induced protein TIR2; Serine-rich protein 2; TIP1-related protein 2", "protein_names_refseq": "putative GPI-anchored mannoprotein", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR010C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11292809;24374639;7746155;8896276;9169874", "class_list": "", "function": "Component of the cell wall., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W277", "ec_number_list": "", "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0071944 cell periphery;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0071497 cellular response to freezing;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P33890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33893-1", "uniprot_id": "GATB_YEAST", "mass": 61869.0, "length": 541, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "gene_name": "PET112", "organism": "Yeast", "refseq_name": "glutamyl-tRNA(Gln) amidotransferase subunit PET112", "refseq_ac": "NP_009473", "gene_names_uniprotkb": "PET112; YBL0724", "gene_names_refseq": "PET112", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; 6.3.5.-; Cytochrome c oxidase assembly factor PET112; Glu-AdT subunit B", "protein_names_refseq": "glutamyl-tRNA(Gln) amidotransferase subunit PET112", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); combined oxidative phosphorylation deficiency 41 (Disease Ontology:DOID:0112119)", "pathway": " (sce:YBL080C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;14576278;19417106;24374639;7502586;7813418;8082172", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, PubMed, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPS3", "ec_number_list": "6.3.5.-;6.3.5.7", "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P33893-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33894-1", "uniprot_id": "STE13_YEAST", "mass": 107200.0, "length": 931, "protein_name": "Dipeptidyl aminopeptidase A", "gene_name": "STE13", "organism": "Yeast", "refseq_name": "Ste13p", "refseq_ac": "NP_014862", "gene_names_uniprotkb": "STE13; YCI1; YOR50-9", "gene_names_refseq": "STE13; YCI1", "protein_names_uniprotkb": "Dipeptidyl aminopeptidase A; 3.4.14.-; DPAP A; YSCIV", "protein_names_refseq": "Ste13p", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 33 (Disease Ontology:DOID:0070063); spinal muscular atrophy (Disease Ontology:DOID:12377); asthma (Disease Ontology:DOID:2841); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YOR219C); (R-SCE-381771)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "15647379;17287358;19779198;24374639;32597660;33229814;33481703;33491328;7975897;8509444;8840505;9169874", "class_list": "", "function": "Responsible for the proteolytic maturation of the alpha-factor precursor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W2S4;Q9URF1", "ec_number_list": "3.4.14.-", "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005774 vacuolar membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006508 proteolysis;GO:0019236 response to pheromone;GO:0007323 peptide pheromone maturation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P33894-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34165-1", "uniprot_id": "MFA1_YEAST", "mass": 3927.0, "length": 36, "protein_name": "Mating hormone A-factor 1", "gene_name": "MFA1", "organism": "Yeast", "refseq_name": "mating pheromone a", "refseq_ac": "NP_010749", "gene_names_uniprotkb": "MFA1; D8035.5", "gene_names_refseq": "MFA1", "protein_names_uniprotkb": "Mating hormone A-factor 1", "protein_names_refseq": "mating pheromone a", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR461W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10022942;11581258;14562106;16963638;17322287;1764063;2046670;2050108;24374639;3056940;3285180;3542988;7569998;9015298;9169867", "class_list": "", "function": "The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). The secreted pheromone binds to a specific receptor STE3 on the surface of the opposite cell type to stimulate a G protein-coupled mating response pathway. It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A. The cells undergo cell-cell fusion and nuclear fusion to form a MATa/MATalpha diploid., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT85", "ec_number_list": "", "go_molecular_function": "GO:0000772 mating pheromone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P34165-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34166-1", "uniprot_id": "MFA2_YEAST", "mass": 4229.0, "length": 38, "protein_name": "Mating hormone A-factor 2", "gene_name": "MFA2", "organism": "Yeast", "refseq_name": "mating pheromone a", "refseq_ac": "NP_014254", "gene_names_uniprotkb": "MFA2; N1204; N1787", "gene_names_refseq": "MFA2", "protein_names_uniprotkb": "Mating hormone A-factor 2", "protein_names_refseq": "mating pheromone a", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL145W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11581258;1358757;17322287;2046670;24374639;3056940;3285180;3542988;8619318;8686380;9015298;9169873", "class_list": "", "function": "The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). The secreted pheromone binds to a specific receptor STE3 on the surface of the opposite cell type to stimulate a G protein-coupled mating response pathway. It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A. The cells undergo cell-cell fusion and nuclear fusion to form a MATa/MATalpha diploid., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W138", "ec_number_list": "", "go_molecular_function": "GO:0000772 mating pheromone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P34166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34220-1", "uniprot_id": "YBF5_YEAST", "mass": 47390.0, "length": 418, "protein_name": "Deoxyribonuclease Tat-D", "gene_name": "YBL0511; YBL0512", "organism": "Yeast", "refseq_name": "3'-5'-exodeoxyribonuclease", "refseq_ac": "NP_009498", "gene_names_uniprotkb": "YBL0511; YBL0512", "gene_names_refseq": "", "protein_names_uniprotkb": "Deoxyribonuclease Tat-D; 3.1.21.-", "protein_names_refseq": "3'-5'-exodeoxyribonuclease", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL055C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;15657035;17322287;24374639;33491328;7813418;8154187", "class_list": "", "function": "Has both endo- and exonuclease activities. Incises double-stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity. May have a role in apoptosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPU5;Q6B2V4", "ec_number_list": "", "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0046872 metal ion binding;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P34220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34232-1", "uniprot_id": "MTR2_YEAST", "mass": 20784.0, "length": 184, "protein_name": "mRNA transport regulator MTR2", "gene_name": "MTR2", "organism": "Yeast", "refseq_name": "Mtr2p", "refseq_ac": "NP_012735", "gene_names_uniprotkb": "MTR2", "gene_names_refseq": "MTR2", "protein_names_uniprotkb": "mRNA transport regulator MTR2", "protein_names_refseq": "Mtr2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL186C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12835756;17322287;18407956;19779198;21126336;21177495;23749301;24374639;33481703;33491328;7865887;8154185;8196765", "class_list": "", "function": "Affects mRNA transport from the nucleus to the cytoplasm., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX14", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0042272 nuclear RNA export factor complex;GO:0005634 nucleus;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006409 tRNA export from nucleus;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P34232-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34237-1", "uniprot_id": "CASP_YEAST", "mass": 77514.0, "length": 679, "protein_name": "Protein CASP", "gene_name": "COY1", "organism": "Yeast", "refseq_name": "CCAAT displacement transcription factor COY1", "refseq_ac": "NP_012742", "gene_names_uniprotkb": "COY1", "gene_names_refseq": "COY1", "protein_names_uniprotkb": "Protein CASP", "protein_names_refseq": "CCAAT displacement transcription factor COY1", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 67 (Disease Ontology:DOID:0112203); stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); hematologic cancer (Disease Ontology:DOID:2531); insulinoma (Disease Ontology:DOID:3892); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YKL179C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12429822;14562106;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;23749301;24374639;32597660;33481703;33491328;8154185;8196765;9332351", "class_list": "", "function": "May be involved in intra-Golgi transport., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX22;P34236", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0048193 Golgi vesicle transport;GO:0048211 Golgi vesicle docking;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P34237-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34239-1", "uniprot_id": "LST4_YEAST", "mass": 93359.0, "length": 828, "protein_name": "Protein LST4", "gene_name": "LST4", "organism": "Yeast", "refseq_name": "Lst4p", "refseq_ac": "NP_012745", "gene_names_uniprotkb": "LST4; YKL642", "gene_names_refseq": "LST4", "protein_names_uniprotkb": "Protein LST4; Lethal with SEC30 protein 4", "protein_names_refseq": "Lst4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL176C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11352928;16641373;17563356;18407956;19779198;21126336;23749301;24374639;32597660;32801125;33229814;33481703;33491328;8091858;8154185;8196765;9409822", "class_list": "", "function": "Involved in extracellular amino acid uptake. Required for the trafficking of the GAP1 nitrogen-regulated general amino acid permease from the Golgi to the plasma membrane., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VX24", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005774 vacuolar membrane;GO:1990877 FNIP-folliculin RagC/D GAP", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0015031 protein transport;GO:0006865 amino acid transport;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P34239-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34240-1", "uniprot_id": "ZRT3_YEAST", "mass": 55403.0, "length": 503, "protein_name": "Zinc-regulated transporter 3", "gene_name": "ZRT3", "organism": "Yeast", "refseq_name": "Zn(2+) transporter ZRT3", "refseq_ac": "NP_012746", "gene_names_uniprotkb": "ZRT3; YKL640", "gene_names_refseq": "ZRT3", "protein_names_uniprotkb": "Zinc-regulated transporter 3; Vacuolar membrane zinc transporter", "protein_names_refseq": "Zn(2+) transporter ZRT3", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL175W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10856230;15665377;17330950;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;24374639;32597660;33481703;33491328;8091858;8154185;8196765", "class_list": "", "function": "Transports zinc from storage in the vacuole to the cytoplasm., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX25", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P34240-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34243-1", "uniprot_id": "HCS1_YEAST", "mass": 78273.0, "length": 683, "protein_name": "DNA polymerase alpha-associated DNA helicase A", "gene_name": "HCS1", "organism": "Yeast", "refseq_name": "ATP-dependent 5'-3' DNA helicase HCS1", "refseq_ac": "NP_012908", "gene_names_uniprotkb": "HCS1; DIP1", "gene_names_refseq": "DIP1; HCS1", "protein_names_uniprotkb": "DNA polymerase alpha-associated DNA helicase A; 5.6.2.3; DNA 5'-3' helicase A", "protein_names_refseq": "ATP-dependent 5'-3' DNA helicase HCS1", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease axonal type 2S (Disease Ontology:DOID:0110171); autosomal recessive distal hereditary motor neuronopathy 1 (Disease Ontology:DOID:0111064)", "pathway": " (sce:YKL017C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10077188;14562095;14562106;24374639;33491328;7681325;8154185;8196765;8257676;8384485;9341217;9341218", "class_list": "", "function": "DNA polymerase alpha-associated 5'-3' DNA helicase which may be involved in DNA replication., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXR9", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0043139 5'-3' DNA helicase activity", "go_cellular_component": "GO:0043601 nuclear replisome;GO:0005737 cytoplasm;GO:0033203 DNA helicase A complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0006301 DNA damage tolerance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P34243-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P34253-1", "uniprot_id": "KTI12_YEAST", "mass": 35322.0, "length": 313, "protein_name": "Protein KTI12", "gene_name": "KTI12", "organism": "Yeast", "refseq_name": "Kti12p", "refseq_ac": "NP_012812", "gene_names_uniprotkb": "KTI12; YKL446; YKL500", "gene_names_refseq": "KTI12; TOT4", "protein_names_uniprotkb": "Protein KTI12; Gamma-toxin target protein 4; Killer toxin insensitivity protein 12", "protein_names_refseq": "Kti12p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL110C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11296232;11929532;12139626;12424236;14562095;14562106;14718557;1561835;15769872;15772087;18986986;19795423;19823750;24374639;2511628;25569479;33491328;8065362;8109175;8196765", "class_list": "", "function": "Elongator complex-associated factor that is not a structural subunit but rather transiently contacts the complex. Regulates elongator complex gamma-toxin target (TOT) activity, resulting in G1 block by Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin), probably through regulation of the ELP1/IKI3 subunit phosphorylation state. Required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXH7;Q05155", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P34253-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35127-1", "uniprot_id": "UBL1_YEAST", "mass": 26385.0, "length": 236, "protein_name": "Ubiquitin carboxyl-terminal hydrolase YUH1", "gene_name": "YUH1", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease YUH1", "refseq_ac": "NP_012633", "gene_names_uniprotkb": "YUH1; J1941", "gene_names_refseq": "YUH1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase YUH1; 3.4.19.12; UCH; Ubiquitin thioesterase", "protein_names_refseq": "ubiquitin-specific protease YUH1", "tax_id": 559292, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); hereditary spastic paraplegia 79A (Disease Ontology:DOID:0070455); hereditary spastic paraplegia 79B (Disease Ontology:DOID:0112344); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); retinal disease (Disease Ontology:DOID:5679); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YJR099W); (R-SCE-5689603); (R-SCE-8951664)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10406793;10527495;12455997;17709260;18407956;21762696;24374639;2555355;33491328;8641269", "class_list": "", "function": "Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or RUB1. Preferentially cleaves ubiquitin from peptides and small adducts., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWR8", "ec_number_list": "3.4.19.12", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0010992 ubiquitin recycling;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030163 protein catabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35176-1", "uniprot_id": "CYPD_YEAST", "mass": 25327.0, "length": 225, "protein_name": "Peptidyl-prolyl cis-trans isomerase D", "gene_name": "CPR5", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase family protein CPR5", "refseq_ac": "NP_010590", "gene_names_uniprotkb": "CPR5; CYP5; CYPD; D9740.14", "gene_names_refseq": "CPR5; CYP5", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase D; 5.2.1.8; Cyclophilin D; Cyclosporin-sensitive proline rotamase 5; PPIase D; Rotamase D", "protein_names_refseq": "peptidylprolyl isomerase family protein CPR5", "tax_id": 559292, "disease": "osteogenesis imperfecta type 9 (Disease Ontology:DOID:0110349)", "pathway": " (sce:YDR304C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17322287;17563356;24374639;29897761;33481703;33491328;8377189;9169867;9371805", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VST3", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35176-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35183-1", "uniprot_id": "AST1_YEAST", "mass": 48349.0, "length": 429, "protein_name": "Protein AST1", "gene_name": "AST1", "organism": "Yeast", "refseq_name": "Ast1p", "refseq_ac": "NP_009484", "gene_names_uniprotkb": "AST1; YBL06.04; YBL0617", "gene_names_refseq": "AST1", "protein_names_uniprotkb": "Protein AST1; ATPAse stabilizing protein 1", "protein_names_refseq": "Ast1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL069W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11739806;24374639;29897761;7813418;7822420;7992509", "class_list": "", "function": "Lipid raft-associated protein involved in the targeting of PMA1 from Golgi to the plasma membrane (PubMed:11739806, PubMed:7822420). May induce clustering of PMA1, which facilitates partition of PMA1 into lipid rafts after leaving the ER and its transport to the cell surface (PubMed:11739806)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPT2;P89492", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0032596 protein transport into membrane raft", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35183-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35184-1", "uniprot_id": "SQT1_YEAST", "mass": 47167.0, "length": 431, "protein_name": "Ribosome assembly protein SQT1", "gene_name": "SQT1", "organism": "Yeast", "refseq_name": "Sqt1p", "refseq_ac": "NP_012277", "gene_names_uniprotkb": "SQT1; YIB12W", "gene_names_refseq": "SQT1", "protein_names_uniprotkb": "Ribosome assembly protein SQT1", "protein_names_refseq": "Sqt1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR012W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;24374639;7762303;7925484;9169870;9271392", "class_list": "", "function": "May be involved in the late step of 60S ribosomal subunit assembly or modification in the cytoplasm., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVU2", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35202-1", "uniprot_id": "THI80_YEAST", "mass": 36616.0, "length": 319, "protein_name": "Thiamine pyrophosphokinase", "gene_name": "THI80", "organism": "Yeast", "refseq_name": "thiamine diphosphokinase", "refseq_ac": "NP_014786", "gene_names_uniprotkb": "THI80; YOR3373C", "gene_names_refseq": "THI80", "protein_names_uniprotkb": "Thiamine pyrophosphokinase; 2.7.6.2; TPK; Thiamine kinase", "protein_names_refseq": "thiamine diphosphokinase", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (sce:YOR143C); (R-SCE-196819)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11435118;14562106;22814378;24374639;8394343;9169874;9200815", "class_list": "", "function": "Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2K1", "ec_number_list": "2.7.6.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004788 thiamine diphosphokinase activity;GO:0030975 thiamine binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0006772 thiamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35202-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35210-1", "uniprot_id": "SPT23_YEAST", "mass": 121338.0, "length": 1082, "protein_name": "Protein SPT23", "gene_name": "SPT23", "organism": "Yeast", "refseq_name": "Spt23p", "refseq_ac": "NP_012905", "gene_names_uniprotkb": "SPT23", "gene_names_refseq": "SPT23", "protein_names_uniprotkb": "Protein SPT23", "protein_names_refseq": "Spt23p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL020C); (R-SCE-8948751)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562106;17563356;18407956;19779198;23749301;24374639;33481703;33491328;8196765;8203154", "class_list": "", "function": "Dosage-dependent suppressor of Ty-induced promoter mutations. May exert its suppression effect through protein-protein interactions since does not present any of the motifs generally found in transcriptional activators or DNA binding proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXR5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070417 cellular response to cold;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:2001280 positive regulation of unsaturated fatty acid biosynthetic process;GO:0030466 silent mating-type cassette heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P35210-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35497-1", "uniprot_id": "DHSO1_YEAST", "mass": 38166.0, "length": 357, "protein_name": "Sorbitol dehydrogenase 1", "gene_name": "SOR1", "organism": "Yeast", "refseq_name": "L-iditol 2-dehydrogenase SOR1", "refseq_ac": "NP_012693", "gene_names_uniprotkb": "SOR1; J2395; SDH1", "gene_names_refseq": "SDH1; SOR1", "protein_names_uniprotkb": "Sorbitol dehydrogenase 1; 1.1.1.-; 1.1.1.9; Polyol dehydrogenase; SDH 1; Xylitol dehydrogenase", "protein_names_refseq": "L-iditol 2-dehydrogenase SOR1", "tax_id": 559292, "disease": "autosomal recessive distal hereditary motor neuronopathy 8 (Disease Ontology:DOID:0081427); cataract (Disease Ontology:DOID:83); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (sce:YJR159W); (R-SCE-5652227); (R-SCE-5661270)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17322287;24374639;8125328;8641269", "class_list": "", "function": "Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) and xylitol as substrates, leading to the C2-oxidized product D-fructose and D-xylulose, respectively. Is likely involved in the utilization of D-sorbitol as a sole carbon source for growth. Has no activity on mannitol and primary alcohols such as ethanol., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWX7", "ec_number_list": "1.1.1.-;1.1.1.9", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity;GO:0046526 D-xylulose reductase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019318 hexose metabolic process;GO:0046370 fructose biosynthetic process;GO:0006062 sorbitol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35497-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35723-1", "uniprot_id": "YET1_YEAST", "mass": 23459.0, "length": 206, "protein_name": "Endoplasmic reticulum transmembrane protein 1", "gene_name": "YET1", "organism": "Yeast", "refseq_name": "Yet1p", "refseq_ac": "NP_012858", "gene_names_uniprotkb": "YET1; YKL331", "gene_names_refseq": "YET1", "protein_names_uniprotkb": "Endoplasmic reticulum transmembrane protein 1", "protein_names_refseq": "Yet1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL065C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14557538;14562095;14562106;16847258;17322287;23749301;24374639;32597660;33481703;33491328;8091862;8196765", "class_list": "", "function": "May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXM2;Q6Q5G9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0070973 protein localization to endoplasmic reticulum exit site", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P35723-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35727-1", "uniprot_id": "BLI1_YEAST", "mass": 13521.0, "length": 113, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit BLI1", "gene_name": "BLI1", "organism": "Yeast", "refseq_name": "Bli1p", "refseq_ac": "NP_012862", "gene_names_uniprotkb": "BLI1; YKL321", "gene_names_refseq": "BLI1", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit BLI1; BLOC-1 interactor 1; BLOC-1 subunit BLI1", "protein_names_refseq": "Bli1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL061W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;17322287;21159114;24374639;8091862;8196765", "class_list": "", "function": "Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXM6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35727-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35731-1", "uniprot_id": "FABG_YEAST", "mass": 31184.0, "length": 278, "protein_name": "3-oxoacyl-[acyl-carrier-protein] reductase", "gene_name": "OAR1", "organism": "Yeast", "refseq_name": "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)", "refseq_ac": "NP_012868", "gene_names_uniprotkb": "OAR1", "gene_names_refseq": "OAR1", "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] reductase; 1.1.1.100; 3-ketoacyl-acyl carrier protein reductase", "protein_names_refseq": "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)", "tax_id": 559292, "disease": "mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YKL055C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;24374639;8091862;8196765;9388293", "class_list": "", "function": "Involved in biosynthesis of fatty acids in mitochondria., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXN2", "ec_number_list": "1.1.1.100;2.3.1.41;2.3.1.86", "go_molecular_function": "GO:0048038 quinone binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35735-1", "uniprot_id": "SFK1_YEAST", "mass": 40463.0, "length": 353, "protein_name": "Protein SFK1", "gene_name": "SFK1", "organism": "Yeast", "refseq_name": "Sfk1p", "refseq_ac": "NP_012873", "gene_names_uniprotkb": "SFK1; YKL303", "gene_names_refseq": "SFK1", "protein_names_uniprotkb": "Protein SFK1; Suppressor of four kinase protein 1", "protein_names_refseq": "Sfk1p", "tax_id": 559292, "disease": "cone-rod dystrophy 21 (Disease Ontology:DOID:0081447); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (sce:YKL051W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12015967;14562095;16847258;19779198;19823750;23749301;24374639;33481703;33491328;8091862;8196765", "class_list": "", "function": "May control the production of phosphatidylinositol 4-phosphate (PI4P) by the STT4 PI 4-kinase. Mediates proper localization of STT4 to the plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXN6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0030036 actin cytoskeleton organization;GO:0007033 vacuole organization;GO:0061093 negative regulation of phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35842-1", "uniprot_id": "PPAB_YEAST", "mass": 52758.0, "length": 467, "protein_name": "Acid phosphatase PHO11", "gene_name": "PHO11", "organism": "Yeast", "refseq_name": "acid phosphatase PHO11", "refseq_ac": "NP_009434", "gene_names_uniprotkb": "PHO11", "gene_names_refseq": "PHO11", "protein_names_uniprotkb": "Acid phosphatase PHO11; 3.1.3.2; P56", "protein_names_refseq": "acid phosphatase PHO11", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 16 (Disease Ontology:DOID:0112333); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (sce:YAR071W)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14562106;24374639;7731988", "class_list": "", "function": "", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6VPP1", "ec_number_list": "3.1.3.2;3.1.3.1;3.1.3.54;3.1.7.6;3.1.3.48", "go_molecular_function": "GO:0003993 acid phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0071944 cell periphery;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35842-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35996-1", "uniprot_id": "RM38_YEAST", "mass": 14905.0, "length": 138, "protein_name": "Large ribosomal subunit protein uL14m", "gene_name": "MRPL38", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL14m MRPL38", "refseq_ac": "NP_012751", "gene_names_uniprotkb": "MRPL38; MRPL34; YKL634", "gene_names_refseq": "MRPL38; uL14m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL14m; 54S ribosomal protein L38, mitochondrial; YmL34; YmL38", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL14m MRPL38", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL170W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12392552;14562095;14562106;16823961;17322287;2060626;23749301;24374639;24675956;25609543;8091858;8196765;9151978", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX30;P36529", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P35996-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36001-1", "uniprot_id": "FOLC_YEAST", "mass": 48143.0, "length": 430, "protein_name": "Probable folylpolyglutamate synthase", "gene_name": "RMA1", "organism": "Yeast", "refseq_name": "putative tetrahydrofolate synthase", "refseq_ac": "NP_012790", "gene_names_uniprotkb": "RMA1", "gene_names_refseq": "RMA1", "protein_names_uniprotkb": "Probable folylpolyglutamate synthase; 6.3.2.17; FPGS; Folylpoly-gamma-glutamate synthetase; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase", "protein_names_refseq": "putative tetrahydrofolate synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL132C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14576278;22218487;24374639;8196765", "class_list": "", "function": "Conversion of folates to polyglutamate derivatives., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX64", "ec_number_list": "6.3.2.17", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016881 acid-amino acid ligase activity;GO:0004326 tetrahydrofolylpolyglutamate synthase activity;GO:0008841 dihydrofolate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0009396 folic acid-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P36001-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36002-1", "uniprot_id": "PTK1_YEAST", "mass": 73502.0, "length": 662, "protein_name": "Serine/threonine-protein kinase PTK1/STK1", "gene_name": "PTK1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase PTK1", "refseq_ac": "NP_012723", "gene_names_uniprotkb": "PTK1; POT1; STK1; YKL199C", "gene_names_refseq": "KKT8; POT1; PTK1; STK1; YKL199C; YKT9", "protein_names_uniprotkb": "Serine/threonine-protein kinase PTK1/STK1; 2.7.11.1", "protein_names_refseq": "putative serine/threonine protein kinase PTK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL198C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19779198;23749301;24374639;32597660;33481703;33491328;7488221;8196765;9154797", "class_list": "", "function": "Essential determinant for low-affinity spermidine transport., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VX02;P36045;Q06941", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000296 spermine transport;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P36002-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36004-1", "uniprot_id": "KKQ8_YEAST", "mass": 82590.0, "length": 724, "protein_name": "Probable serine/threonine-protein kinase KKQ8", "gene_name": "KKQ8", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase KKQ8", "refseq_ac": "NP_012753", "gene_names_uniprotkb": "KKQ8; YKL632", "gene_names_refseq": "KKQ8", "protein_names_uniprotkb": "Probable serine/threonine-protein kinase KKQ8; 2.7.11.1", "protein_names_refseq": "putative serine/threonine protein kinase KKQ8", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL168C); (R-SCE-176187); (R-SCE-5693616); (R-SCE-69601)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "12748633;12775844;14562095;14562106;15665377;17287358;17330950;17563356;18407956;19779198;20489023;20702584;21126336;21177495;23749301;24374639;24909858;30516470;32597660;33481703;33491328;8091858;8196765", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX31", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.48;2.7.11.13;3.6.4.-;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P36004-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36019-1", "uniprot_id": "YPT53_YEAST", "mass": 24648.0, "length": 220, "protein_name": "GTP-binding protein YPT53", "gene_name": "YPT53", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT53", "refseq_ac": "NP_014306", "gene_names_uniprotkb": "YPT53; N2223", "gene_names_refseq": "YPT53", "protein_names_uniprotkb": "GTP-binding protein YPT53", "protein_names_refseq": "Rab family GTPase YPT53", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (sce:YNL093W); (R-SCE-6798695); (R-SCE-8873719); (R-SCE-8876198); (R-SCE-983231)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "11907579;14562106;16273108;17322287;24374639;32391792;33481703;33491328;8163546;8771715;9169873", "class_list": "", "function": "Required for transport in the endocytic pathway and for correct sorting of the vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway. May be involved in recruiting the MON1-CCZ1 complex to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns[3]P) or other charged lipids, leading to recruitment of YPT7 (PubMed:32391792)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W187;Q45TZ5", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0005770 late endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0006895 Golgi to endosome transport;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36019-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36023-1", "uniprot_id": "OAF3_YEAST", "mass": 101825.0, "length": 863, "protein_name": "Oleate activated transcription factor 3", "gene_name": "OAF3", "organism": "Yeast", "refseq_name": "Oaf3p", "refseq_ac": "NP_012990", "gene_names_uniprotkb": "OAF3", "gene_names_refseq": "OAF3", "protein_names_uniprotkb": "Oleate activated transcription factor 3", "protein_names_refseq": "Oaf3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR064W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14576278;16959962;17551510;18621837;24374639;32597660;33481703;33491328;8196765", "class_list": "", "function": "Transcriptional inhibitor with a significantly increased number of target genes in response to oleate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36023-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36036-1", "uniprot_id": "YRA2_YEAST", "mass": 23778.0, "length": 203, "protein_name": "RNA annealing protein YRA2", "gene_name": "YRA2", "organism": "Yeast", "refseq_name": "Yra2p", "refseq_ac": "NP_012708", "gene_names_uniprotkb": "YRA2", "gene_names_refseq": "YRA2", "protein_names_uniprotkb": "RNA annealing protein YRA2", "protein_names_refseq": "Yra2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL214C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11390651;14562106;15584090;17922018;18407956;19376128;19795423;19823750;22814378;24374639;32597660;33491328;7941750;8196765", "class_list": "", "function": "Involved in export of poly(A) mRNAs from the nucleus. Recruited to the coding sequences as well as poly-A sites of active genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWY9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P36036-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36039-1", "uniprot_id": "EMC3_YEAST", "mass": 28352.0, "length": 253, "protein_name": "ER membrane protein complex subunit 3", "gene_name": "EMC3", "organism": "Yeast", "refseq_name": "ER membrane complex subunit EMC3", "refseq_ac": "NP_012715", "gene_names_uniprotkb": "EMC3; AIM27", "gene_names_refseq": "AIM27; EMC3", "protein_names_uniprotkb": "ER membrane protein complex subunit 3; Altered inheritance rate of mitochondria protein 27", "protein_names_refseq": "ER membrane complex subunit EMC3", "tax_id": 559292, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (sce:YKL207W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12748633;12775844;12844361;19325107;24374639;29809151;8196765", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWZ6;Q86ZT1", "ec_number_list": "", "go_molecular_function": "GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0072546 EMC complex", "go_biological_process": "GO:0015914 phospholipid transport;GO:0006644 phospholipid metabolic process;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0034975 protein folding in endoplasmic reticulum;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36040-1", "uniprot_id": "POC2_YEAST", "mass": 30739.0, "length": 267, "protein_name": "Proteasome assembly chaperone 2", "gene_name": "ADD66", "organism": "Yeast", "refseq_name": "Add66p", "refseq_ac": "NP_012716", "gene_names_uniprotkb": "ADD66; PBA2; POC2", "gene_names_refseq": "ADD66; PBA2; POC2", "protein_names_uniprotkb": "Proteasome assembly chaperone 2; Alpha-1-proteinase inhibitor-degradation deficient protein 66; Proteasome biogenesis-associated protein 2", "protein_names_refseq": "Add66p", "tax_id": 559292, "disease": "proteosome-associated autoinflammatory syndrome 4 (Disease Ontology:DOID:0060915)", "pathway": " (sce:YKL206C); (R-SCE-9907900)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12711700;14562106;17322287;17431397;17634286;17707236;23749301;24374639;33481703;33491328;8196765", "class_list": "", "function": "Involved in 20S proteasome assembly. Required for maximal proteasome activity. Affects the chymotrypsin-like activity of the proteasome. Can be degraded by the proteasome. Involved in the endoplasmic reticulum-associated degradation (ERAD)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWZ7", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043248 proteasome assembly;GO:0080129 proteasome core complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36040-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36053-1", "uniprot_id": "ELF1_YEAST", "mass": 16157.0, "length": 145, "protein_name": "Transcription elongation factor 1", "gene_name": "ELF1", "organism": "Yeast", "refseq_name": "Elf1p", "refseq_ac": "NP_012762", "gene_names_uniprotkb": "ELF1; YKL614", "gene_names_refseq": "ELF1", "protein_names_uniprotkb": "Transcription elongation factor 1", "protein_names_refseq": "Elf1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL160W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14562095;14562106;15665377;16260625;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;8091859;8196765", "class_list": "", "function": "Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX39", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P36053-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36056-1", "uniprot_id": "RT22_YEAST", "mass": 72190.0, "length": 628, "protein_name": "Ribosome assembly protein RSM22, mitochondrial", "gene_name": "RSM22", "organism": "Yeast", "refseq_name": "tRNA methyltransferase RSM22", "refseq_ac": "NP_012767", "gene_names_uniprotkb": "RSM22; YKL610", "gene_names_refseq": "RSM22", "protein_names_uniprotkb": "Ribosome assembly protein RSM22, mitochondrial", "protein_names_refseq": "tRNA methyltransferase RSM22", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL155C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11278769;12392552;14562095;14562106;16823961;19779198;22689777;24374639;24651469;28154081;33491328;36482135;38199006;8091859;8196765", "class_list": "", "function": "Mitochondrial ribosome (mitoribosome) assembly factor (PubMed:36482135, PubMed:38199006). Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body (PubMed:36482135). Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX43", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0008168 methyltransferase activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36056-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36059-1", "uniprot_id": "NNRD_YEAST", "mass": 37357.0, "length": 337, "protein_name": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase", "gene_name": "NNR2", "organism": "Yeast", "refseq_name": "NADHX dehydratase", "refseq_ac": "NP_012771", "gene_names_uniprotkb": "NNR2; YKL606", "gene_names_refseq": "NNR2", "protein_names_uniprotkb": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase; 4.2.1.93; ATP-dependent NAD(P)HX dehydratase; Nicotinamide nucleotide repair protein 2", "protein_names_refseq": "NADHX dehydratase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL151C); (R-SCE-196807)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "13331940;14562095;14562106;17322287;18407956;21126336;21994945;22814378;24374639;3061454;33491328;8091859;8196765", "class_list": "", "function": "Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX46;Q6Q5N3", "ec_number_list": "4.2.1.93", "go_molecular_function": "GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046496 nicotinamide nucleotide metabolic process;GO:0110051 metabolite repair", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P36059-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36062-1", "uniprot_id": "AVT3_YEAST", "mass": 75459.0, "length": 692, "protein_name": "Vacuolar amino acid transporter 3", "gene_name": "AVT3", "organism": "Yeast", "refseq_name": "Avt3p", "refseq_ac": "NP_012776", "gene_names_uniprotkb": "AVT3; YKL600", "gene_names_refseq": "AVT3", "protein_names_uniprotkb": "Vacuolar amino acid transporter 3", "protein_names_refseq": "Avt3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL146W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11274162;17330950;17563356;18407956;19779198;19795423;19823750;21126336;21177495;22218487;22814378;23749301;24374639;24909858;32597660;33481703;33491328;8091859;8196765", "class_list": "", "function": "Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX50", "ec_number_list": "", "go_molecular_function": "GO:0015188 L-isoleucine transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0005302 L-tyrosine transmembrane transporter activity", "go_cellular_component": "GO:0005774 vacuolar membrane;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015824 proline transport;GO:0003333 amino acid transmembrane transport;GO:0032974 amino acid transmembrane export from vacuole", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P36062-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36064-1", "uniprot_id": "COXM1_YEAST", "mass": 13007.0, "length": 111, "protein_name": "COX assembly mitochondrial protein", "gene_name": "CMC1", "organism": "Yeast", "refseq_name": "Cmc1p", "refseq_ac": "NP_012785", "gene_names_uniprotkb": "CMC1", "gene_names_refseq": "CMC1", "protein_names_uniprotkb": "COX assembly mitochondrial protein; COX biogenesis factor CMC1; Cx9C mitochondrial COX assembly protein 1; Mitochondrial metallochaperone-like protein CMC1", "protein_names_refseq": "Cmc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL137W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12748633;14562106;18443040;19703468;20220131;22984289;24374639;8196765", "class_list": "", "function": "Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. Binds copper. May be involved in copper trafficking and distribution to mitochondrial COX and SOD1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX60", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P36064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36070-1", "uniprot_id": "RRN3_YEAST", "mass": 72388.0, "length": 627, "protein_name": "RNA polymerase I-specific transcription initiation factor RRN3", "gene_name": "RRN3", "organism": "Yeast", "refseq_name": "rDNA-binding RNA polymerase I transcriptional factor", "refseq_ac": "NP_012797", "gene_names_uniprotkb": "RRN3", "gene_names_refseq": "RRN3", "protein_names_uniprotkb": "RNA polymerase I-specific transcription initiation factor RRN3", "protein_names_refseq": "rDNA-binding RNA polymerase I transcriptional factor", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YKL125W); (R-SCE-73762); (R-SCE-73772)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "14562106;18631361;24374639;33229814;8196765;8670901", "class_list": "", "function": "Required for efficient transcription initiation by RNA polymerase I. Interacts with Pol I in the absence of template DNA and stimulates recruitment of Pol I, but does not remain as part of stable preinitiation complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VX70", "ec_number_list": "", "go_molecular_function": "GO:0000182 rDNA binding;GO:0001179 RNA polymerase I general transcription initiation factor binding;GO:0001181 RNA polymerase I general transcription initiation factor activity;GO:0001042 RNA polymerase I core binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006361 transcription initiation at RNA polymerase I promoter", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P36070-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36091-1", "uniprot_id": "DCW1_YEAST", "mass": 49565.0, "length": 449, "protein_name": "Mannan endo-1,6-alpha-mannosidase DCW1", "gene_name": "DCW1", "organism": "Yeast", "refseq_name": "putative mannan endo-1,6-alpha-mannosidase", "refseq_ac": "NP_012878", "gene_names_uniprotkb": "DCW1; YKL259", "gene_names_refseq": "DCW1", "protein_names_uniprotkb": "Mannan endo-1,6-alpha-mannosidase DCW1; 3.2.1.101; Defective cell wall 1; Endo-alpha-1->6-D-mannanase DCW1", "protein_names_refseq": "putative mannan endo-1,6-alpha-mannosidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL046C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12421307;14562106;17322287;24374639;8154189;8196765", "class_list": "", "function": "Required for normal synthesis of the cell wall., [UniProtKB, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "D6VXP1;Q66R60", "ec_number_list": "", "go_molecular_function": "GO:0008496 mannan endo-1,6-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005933 cellular bud;GO:0098552 side of membrane", "go_biological_process": "GO:0016052 carbohydrate catabolic process;GO:0007117 budding cell bud growth;GO:0009272 fungal-type cell wall biogenesis;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36091-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36093-1", "uniprot_id": "PHD1_YEAST", "mass": 40646.0, "length": 366, "protein_name": "Putative transcription factor PHD1", "gene_name": "PHD1", "organism": "Yeast", "refseq_name": "Phd1p", "refseq_ac": "NP_012881", "gene_names_uniprotkb": "PHD1; YKL256", "gene_names_refseq": "PHD1", "protein_names_uniprotkb": "Putative transcription factor PHD1", "protein_names_refseq": "Phd1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL043W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;17322287;22124158;23749301;24374639;32597660;33481703;33491328;8114741;8154189;8196765", "class_list": "", "function": "Putative transcription factor that functions in pseudohyphal growth., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXP3;Q2VQ88", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:2000222 positive regulation of pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36093-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36101-1", "uniprot_id": "TCD2_YEAST", "mass": 50266.0, "length": 447, "protein_name": "tRNA threonylcarbamoyladenosine dehydratase 2", "gene_name": "TCD2", "organism": "Yeast", "refseq_name": "tRNA threonylcarbamoyladenosine dehydratase", "refseq_ac": "NP_012898", "gene_names_uniprotkb": "TCD2", "gene_names_refseq": "TCD2", "protein_names_uniprotkb": "tRNA threonylcarbamoyladenosine dehydratase 2; 6.1.-.-; t(6)A37 dehydratase 2", "protein_names_refseq": "tRNA threonylcarbamoyladenosine dehydratase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL027W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;14576278;16407407;17322287;17330950;19779198;23242255;24374639;32597660;33491328;8196765", "class_list": "", "function": "Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ7;Q6B2N9", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008641 ubiquitin-like modifier activating enzyme activity;GO:0061503 tRNA threonylcarbamoyladenosine dehydratase", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0061504 cyclic threonylcarbamoyladenosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36101-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36106-1", "uniprot_id": "BYE1_YEAST", "mass": 67901.0, "length": 594, "protein_name": "Transcription factor BYE1", "gene_name": "BYE1", "organism": "Yeast", "refseq_name": "Bye1p", "refseq_ac": "NP_012921", "gene_names_uniprotkb": "BYE1; YKL150", "gene_names_refseq": "BYE1", "protein_names_uniprotkb": "Transcription factor BYE1; Bypass of ESS1 protein 1", "protein_names_refseq": "Bye1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL005C); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "14562106;14704159;17142463;19779198;21177495;24374639;33481703;33491328;8196765;8488728", "class_list": "", "function": "Negative regulator of transcription elongation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXT2", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P36106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36110-1", "uniprot_id": "PRY2_YEAST", "mass": 33780.0, "length": 329, "protein_name": "Protein PRY2", "gene_name": "PRY2", "organism": "Yeast", "refseq_name": "sterol-binding protein", "refseq_ac": "NP_012938", "gene_names_uniprotkb": "PRY2; YK111", "gene_names_refseq": "PRY2; YFW12", "protein_names_uniprotkb": "Protein PRY2; Pathogenesis-related protein 2", "protein_names_refseq": "sterol-binding protein", "tax_id": 559292, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (sce:YKR013W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11935221;23027975;24374639;8196765", "class_list": "", "function": "Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VX78", "ec_number_list": "", "go_molecular_function": "GO:0032934 sterol binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015908 fatty acid transport;GO:0015918 sterol transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P36110-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36118-1", "uniprot_id": "NTR2_YEAST", "mass": 36647.0, "length": 322, "protein_name": "Pre-mRNA-splicing factor NTR2", "gene_name": "NTR2", "organism": "Yeast", "refseq_name": "Ntr2p", "refseq_ac": "NP_012947", "gene_names_uniprotkb": "NTR2", "gene_names_refseq": "NTR2", "protein_names_uniprotkb": "Pre-mRNA-splicing factor NTR2; NTC-related protein 2; Nineteen complex-related protein 2", "protein_names_refseq": "Ntr2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR022C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;14690591;16357217;16880513;18407956;19779198;19795423;19823750;23749301;24374639;32597660;33481703;33491328;8196765", "class_list": "", "function": "Involved in pre-mRNA splicing and spliceosome disassembly. Promotes release of excised lariat intron from the spliceosome by acting as a receptor for PRP43. This targeting of PRP43 leads to disassembly of the spliceosome with the separation of the U2, U5, U6 snRNPs and the NTC complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX87", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005681 spliceosomal complex;GO:0071008 U2-type post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36118-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36120-1", "uniprot_id": "DBP7_YEAST", "mass": 83308.0, "length": 742, "protein_name": "ATP-dependent RNA helicase DBP7", "gene_name": "DBP7", "organism": "Yeast", "refseq_name": "putative ATP-dependent RNA helicase", "refseq_ac": "NP_012949", "gene_names_uniprotkb": "DBP7", "gene_names_refseq": "DBP7", "protein_names_uniprotkb": "ATP-dependent RNA helicase DBP7; 3.6.4.13; DEAD box protein 7", "protein_names_refseq": "putative ATP-dependent RNA helicase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR024C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14562106;17563356;18407956;21126336;23749301;24374639;32597660;33229814;33481703;33491328;8196765;9582098", "class_list": "", "function": "ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VX89", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P36120-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36121-1", "uniprot_id": "RPC5_YEAST", "mass": 32142.0, "length": 282, "protein_name": "DNA-directed RNA polymerase III subunit RPC5", "gene_name": "RPC37", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase III subunit C37", "refseq_ac": "NP_012950", "gene_names_uniprotkb": "RPC37", "gene_names_refseq": "RPC37", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC5; DNA-directed RNA polymerase III 37 kDa polypeptide; RNA polymerase III subunit C37; RNA polymerase III subunit C5", "protein_names_refseq": "DNA-directed RNA polymerase III subunit C37", "tax_id": 559292, "disease": "chromosome 16p12.1 deletion syndrome (Disease Ontology:DOID:0060399)", "pathway": " (sce:YKR025W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10384303;10393904;14562095;14562106;16362040;17322287;17563356;18407956;19779198;19795423;19823750;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;8196765", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX90", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P36121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36144-1", "uniprot_id": "RL1D1_YEAST", "mass": 31616.0, "length": 274, "protein_name": "Ribosome biogenesis protein UTP30", "gene_name": "UTP30", "organism": "Yeast", "refseq_name": "Utp30p", "refseq_ac": "NP_012986", "gene_names_uniprotkb": "UTP30", "gene_names_refseq": "UTP30", "protein_names_uniprotkb": "Ribosome biogenesis protein UTP30; U3 snoRNP-associated protein UTP30", "protein_names_refseq": "Utp30p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR060W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12150911;14562095;14562106;16544271;16762320;17322287;17563356;19779198;19795423;19823750;23749301;24374639;33481703;33491328;8196765", "class_list": "", "function": "Involved in rRNA-processing and ribosome biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36144-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36145-1", "uniprot_id": "T2EB_YEAST", "mass": 36985.0, "length": 328, "protein_name": "Transcription initiation factor IIE subunit beta", "gene_name": "TFA2", "organism": "Yeast", "refseq_name": "transcription factor TFIIE subunit TFA2", "refseq_ac": "NP_012988", "gene_names_uniprotkb": "TFA2", "gene_names_refseq": "TFA2", "protein_names_uniprotkb": "Transcription initiation factor IIE subunit beta; Factor A 43 kDa subunit; TFIIE-beta; Transcription factor A small subunit", "protein_names_refseq": "transcription factor TFIIE subunit TFA2", "tax_id": 559292, "disease": "nonphotosensitive trichothiodystrophy 6 (Disease Ontology:DOID:0111872)", "pathway": " (sce:YKR062W); (R-SCE-674695); (R-SCE-6807505); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "14562106;17287358;17563356;18407956;19779198;19795423;19823750;20702584;21177495;23749301;24374639;30516470;32597660;33481703;33491328;7961670;8196765", "class_list": "", "function": "Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC3;P42569", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005673 transcription factor TFIIE complex;GO:0005634 nucleus", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P36145-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36147-1", "uniprot_id": "PAM17_YEAST", "mass": 21968.0, "length": 197, "protein_name": "Presequence translocated-associated motor subunit PAM17, mitochondrial", "gene_name": "PAM17", "organism": "Yeast", "refseq_name": "Pam17p", "refseq_ac": "NP_012991", "gene_names_uniprotkb": "PAM17; FMP18", "gene_names_refseq": "FMP18; PAM17", "protein_names_uniprotkb": "Presequence translocated-associated motor subunit PAM17, mitochondrial", "protein_names_refseq": "Pam17p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR065C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562095;14562106;16107694;24374639;8196765", "class_list": "", "function": "Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to organize PAM16-PAM18 (TIM16-TIM14) heterodimer., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXC6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P36147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36166-1", "uniprot_id": "PXL1_YEAST", "mass": 79434.0, "length": 706, "protein_name": "Paxillin-like protein 1", "gene_name": "PXL1", "organism": "Yeast", "refseq_name": "Pxl1p", "refseq_ac": "NP_013016", "gene_names_uniprotkb": "PXL1", "gene_names_refseq": "PXL1", "protein_names_uniprotkb": "Paxillin-like protein 1", "protein_names_refseq": "Pxl1p", "tax_id": 559292, "disease": "combined pituitary hormone deficiency 4 (Disease Ontology:DOID:0061017)", "pathway": " (sce:YKR090W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562106;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8196765", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 43, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VXF0", "ec_number_list": "", "go_molecular_function": "GO:0005094 Rho GDP-dissociation inhibitor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030427 site of polarized growth;GO:0000131 incipient cellular bud site;GO:0005933 cellular bud;GO:0005934 cellular bud tip", "go_biological_process": "GO:0035023 regulation of Rho protein signal transduction;GO:0030011 maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P36166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36167-1", "uniprot_id": "SRL3_YEAST", "mass": 27466.0, "length": 246, "protein_name": "Protein SRL3", "gene_name": "SRL3", "organism": "Yeast", "refseq_name": "DNA-binding protein SRL3", "refseq_ac": "NP_013017", "gene_names_uniprotkb": "SRL3; YKR411", "gene_names_refseq": "SRL3; WHI7", "protein_names_uniprotkb": "Protein SRL3; RAD53 lethality suppressor protein 3", "protein_names_refseq": "DNA-binding protein SRL3", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR091W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11914276;12748633;14574415;15200949;17322287;18407956;19779198;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;38233717;8154186;8196765", "class_list": "", "function": "Weakly suppresses a RAD53 null mutation when overexpressed., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VXF1", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0033309 SBF transcription complex", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P36167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36168-1", "uniprot_id": "ESL2_YEAST", "mass": 137491.0, "length": 1195, "protein_name": "EST/SMG-like protein 2", "gene_name": "ESL2", "organism": "Yeast", "refseq_name": "Esl2p", "refseq_ac": "NP_013022", "gene_names_uniprotkb": "ESL2", "gene_names_refseq": "ESL2", "protein_names_uniprotkb": "EST/SMG-like protein 2", "protein_names_refseq": "Esl2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR096W); (R-SCE-975957)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562095;14562106;17563356;18407956;22375831;23749301;23893744;24374639;32597660;33481703;33491328;8196765", "class_list": "", "function": "May be involved in the regulation of gene expression responses of environment-sensing pathways., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXF7", "ec_number_list": "", "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P36168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36169-1", "uniprot_id": "SKG1_YEAST", "mass": 39830.0, "length": 355, "protein_name": "Suppressor of lethality of KEX2 GAS1 double null mutant protein 1", "gene_name": "SKG1", "organism": "Yeast", "refseq_name": "Skg1p", "refseq_ac": "NP_013026", "gene_names_uniprotkb": "SKG1; YKR099C-A", "gene_names_refseq": "SKG1; YKR099C-A", "protein_names_uniprotkb": "Suppressor of lethality of KEX2 GAS1 double null mutant protein 1", "protein_names_refseq": "Skg1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR100C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12844361;14562095;15645486;15665377;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;8196765", "class_list": "", "function": "Plays a role in cell wall integrity. Affects the cell wall polymer composition in the growing region of the cell., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXG1;Q86ZT0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000131 incipient cellular bud site;GO:0005933 cellular bud;GO:0005934 cellular bud tip;GO:0033101 cellular bud membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P36169-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36173-1", "uniprot_id": "GEX2_YEAST", "mass": 68954.0, "length": 615, "protein_name": "Glutathione exchanger 2", "gene_name": "GEX2", "organism": "Yeast", "refseq_name": "glutathione exchanger", "refseq_ac": "NP_013032", "gene_names_uniprotkb": "GEX2", "gene_names_refseq": "GEX2", "protein_names_uniprotkb": "Glutathione exchanger 2", "protein_names_refseq": "glutathione exchanger", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR106W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16847258;21490148;24374639;8196765", "class_list": "", "function": "Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXG7", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0015078 proton transmembrane transporter activity;GO:0015343 siderophore-iron transmembrane transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0034775 glutathione transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P36173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36516-1", "uniprot_id": "RM03_YEAST", "mass": 44000.0, "length": 390, "protein_name": "Large ribosomal subunit protein mL44", "gene_name": "MRPL3", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein mL44 MRPL3", "refseq_ac": "NP_013737", "gene_names_uniprotkb": "MRPL3; YM9711.14", "gene_names_refseq": "MRPL3; mL44", "protein_names_uniprotkb": "Large ribosomal subunit protein mL44; 54S ribosomal protein L3, mitochondrial; YmL3", "protein_names_refseq": "mitochondrial 54S ribosomal protein mL44 MRPL3", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 16 (Disease Ontology:DOID:0111469)", "pathway": " (sce:YMR024W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12392552;12426313;14562095;14562106;14576278;17322287;24374639;24675956;25609543;3060376;9169872", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZJ8", "ec_number_list": "", "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0004525 ribonuclease III activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006396 RNA processing;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36519-1", "uniprot_id": "RM07_YEAST", "mass": 33099.0, "length": 292, "protein_name": "Large ribosomal subunit protein uL5m", "gene_name": "MRPL7", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL5m MRPL7", "refseq_ac": "NP_010523", "gene_names_uniprotkb": "MRPL7; YD8419.04", "gene_names_refseq": "MRPL7; uL5m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL5m; 54S ribosomal protein L7, mitochondrial; YmL5; YmL7", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL5m MRPL7", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR237W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14576278;17322287;2060626;24374639;24675956;25609543;9169867", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. 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The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0U1", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P36528-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36532-1", "uniprot_id": "RM37_YEAST", "mass": 11949.0, "length": 105, "protein_name": "Large ribosomal subunit protein mL54", "gene_name": "MRPL37", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein mL54 MRPL37", "refseq_ac": "NP_009827", "gene_names_uniprotkb": "MRPL37; YBR1736A", "gene_names_refseq": "MRPL37; mL54", "protein_names_uniprotkb": "Large ribosomal subunit protein mL54; 54S ribosomal protein L37, mitochondrial; YmL37", "protein_names_refseq": "mitochondrial 54S ribosomal protein mL54 MRPL37", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR268W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14576278;15543521;17322287;2060626;24374639;24675956;25609543;7813418;8465606", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543). mL54 may have a meiosis-specific role as it accumulates during the middle stage of sporulation (PubMed:15543521)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQR4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0030435 sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P36532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36533-1", "uniprot_id": "RM39_YEAST", "mass": 7973.0, "length": 70, "protein_name": "Large ribosomal subunit protein bL33m", "gene_name": "MRPL39", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein bL33m MRPL39", "refseq_ac": "NP_013705", "gene_names_uniprotkb": "MRPL39; YM9571.09C", "gene_names_refseq": "MRPL39; bL33m", "protein_names_uniprotkb": "Large ribosomal subunit protein bL33m; 54S ribosomal protein L39, mitochondrial; YmL39", "protein_names_refseq": "mitochondrial 54S ribosomal protein bL33m MRPL39", "tax_id": 559292, "disease": "", "pathway": " (sce:YML009C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;16823961;2060626;24374639;24675956;25609543;9169872", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZG5", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P36533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36534-1", "uniprot_id": "RM40_YEAST", "mass": 33751.0, "length": 297, "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "MRPL40", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL24m MRPL40", "refseq_ac": "NP_015152", "gene_names_uniprotkb": "MRPL40", "gene_names_refseq": "MRPL40; uL24m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24m; 54S ribosomal protein L40, mitochondrial; YmL40", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL24m MRPL40", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL173W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12392552;12426313;14576278;17322287;2060626;22814378;24374639;24675956;25609543;9169875", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3J5;Q6B277", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P36534-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37262-1", "uniprot_id": "SOL2_YEAST", "mass": 34501.0, "length": 315, "protein_name": "6-phosphogluconolactonase-like protein 2", "gene_name": "SOL2", "organism": "Yeast", "refseq_name": "Sol2p", "refseq_ac": "NP_009999", "gene_names_uniprotkb": "SOL2; YCRX13W", "gene_names_refseq": "SOL2; YCRX13W", "protein_names_uniprotkb": "6-phosphogluconolactonase-like protein 2; Suppressor of LOS1", "protein_names_refseq": "Sol2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCR073W-A)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11875433;14562095;14562106;15454531;1574125;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;23749301;24374639;32597660;33491328;8313894;8725220", "class_list": "", "function": "May be involved in regulation of tRNA subcellular distribution., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR76", "ec_number_list": "", "go_molecular_function": "GO:0017057 6-phosphogluconolactonase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006409 tRNA export from nucleus;GO:0005975 carbohydrate metabolic process;GO:0009051 pentose-phosphate shunt, oxidative branch", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P37262-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37302-1", "uniprot_id": "APE3_YEAST", "mass": 60137.0, "length": 537, "protein_name": "Aminopeptidase Y", "gene_name": "APE3", "organism": "Yeast", "refseq_name": "aminopeptidase Y", "refseq_ac": "NP_009845", "gene_names_uniprotkb": "APE3; YBR2024", "gene_names_refseq": "APE3; APY1", "protein_names_uniprotkb": "Aminopeptidase Y; 3.4.11.15", "protein_names_refseq": "aminopeptidase Y", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR286W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;24374639;33481703;33491328;7813418;8091861;8175799;8175800", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VQT1;P38154", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity", "go_cellular_component": "GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006508 proteolysis;GO:0007039 protein catabolic process in the vacuole", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P37302-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P37898-1", "uniprot_id": "AAP1_YEAST", "mass": 97663.0, "length": 856, "protein_name": "Alanine/arginine aminopeptidase", "gene_name": "AAP1", "organism": "Yeast", "refseq_name": "arginine/alanine aminopeptidase", "refseq_ac": "NP_011913", "gene_names_uniprotkb": "AAP1", "gene_names_refseq": "AAP1'; AAP1", "protein_names_uniprotkb": "Alanine/arginine aminopeptidase; 3.4.11.-", "protein_names_refseq": "arginine/alanine aminopeptidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR047C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;18407956;23749301;24374639;33481703;8091229;8100228", "class_list": "", "function": "Positive effector of glycogen accumulation. May be involved in nutrient-sensing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKZ5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0005977 glycogen metabolic process;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P37898-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38064-1", "uniprot_id": "RM16_YEAST", "mass": 26518.0, "length": 232, "protein_name": "Large ribosomal subunit protein uL16m", "gene_name": "MRPL16", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein uL16m MRPL16", "refseq_ac": "NP_009515", "gene_names_uniprotkb": "MRPL16; RML16; YBL0411", "gene_names_refseq": "MRPL16; RML16; uL16m", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16m; 54S ribosomal protein L16, mitochondrial; YmL47", "protein_names_refseq": "mitochondrial 54S ribosomal protein uL16m MRPL16", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL038W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;14576278;24374639;24675956;25609543;7478995;7813418;7871888;9151978", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPW1;Q07216", "ec_number_list": "", "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38065-1", "uniprot_id": "AP2A_YEAST", "mass": 115012.0, "length": 1025, "protein_name": "AP-2 complex subunit alpha", "gene_name": "APL3", "organism": "Yeast", "refseq_name": "Apl3p", "refseq_ac": "NP_009516", "gene_names_uniprotkb": "APL3; YBL0412", "gene_names_refseq": "APL3", "protein_names_uniprotkb": "AP-2 complex subunit alpha; Alpha-adaptin; Clathrin assembly protein complex 2 alpha large chain; Clathrin assembly protein large alpha chain", "protein_names_refseq": "Apl3p", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (sce:YBL037W); (R-SCE-437239); (R-SCE-6798695); (R-SCE-8856825); (R-SCE-8856828); (R-SCE-8866427); (R-SCE-8964038)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10564262;14562106;17563356;18407956;19779198;19795423;19823750;20702584;21126336;23749301;24374639;24909858;32597660;33229814;33481703;33491328;7813418;7871888", "class_list": "", "function": "Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adaptor. Facilitates interaction between APL1 and APS2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPW2", "ec_number_list": "", "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0030122 AP-2 adaptor complex;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P38065-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38066-1", "uniprot_id": "RIB1_YEAST", "mass": 38332.0, "length": 345, "protein_name": "GTP cyclohydrolase-2", "gene_name": "RIB1", "organism": "Yeast", "refseq_name": "GTP cyclohydrolase II", "refseq_ac": "NP_009520", "gene_names_uniprotkb": "RIB1; YBL0417", "gene_names_refseq": "RIB1", "protein_names_uniprotkb": "GTP cyclohydrolase-2; 3.5.4.25; GTP cyclohydrolase II", "protein_names_refseq": "GTP cyclohydrolase II", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL033C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;18407956;23749301;24374639;33229814;33491328;7813418;8091857", "class_list": "", "function": "Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPW6", "ec_number_list": "3.5.4.25", "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003935 GTP cyclohydrolase II activity;GO:0019238 cyclohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009231 riboflavin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38067-1", "uniprot_id": "SSDH_YEAST", "mass": 54189.0, "length": 497, "protein_name": "Succinate-semialdehyde dehydrogenase [NADP(+)]", "gene_name": "UGA2", "organism": "Yeast", "refseq_name": "succinate-semialdehyde dehydrogenase (NAD(P)(+))", "refseq_ac": "NP_009560", "gene_names_uniprotkb": "UGA2; UGA5; YBR0112", "gene_names_refseq": "UGA2; UGA5", "protein_names_uniprotkb": "Succinate-semialdehyde dehydrogenase [NADP(+)]; 1.2.1.16; SSA dehydrogenase; SSADH; SSDH", "protein_names_refseq": "succinate-semialdehyde dehydrogenase (NAD(P)(+))", "tax_id": 559292, "disease": "succinic semialdehyde dehydrogenase deficiency (Disease Ontology:DOID:0060175); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (sce:YBR006W); (R-SCE-916853)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562095;22814378;24374639;25092794;33491328;3888627;7813418", "class_list": "", "function": "Catalyzes the oxidation of succinate semialdehyde to succinate. Can utilize both NAD(+) or NADP(+) as a coenzyme, but has a 2.5-fold lower activity with NADP(+) than with NAD(+) (PubMed:25092794). Functions in a gamma-aminobutyrate (GABA) degradation pathway that allows growth utilizing GABA as a nitrogen source (PubMed:3888627). Functions in the GABA shunt, which allows to bypass 2 reactions in the TCA cycle by removing alpha-ketoglutarate from the cycle and feeding succinate and NADH back into the cycle (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ07;E9PAD1", "ec_number_list": "1.2.1.16", "go_molecular_function": "GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity;GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity;GO:0036243 succinate-semialdehyde dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0006540 gamma-aminobutyrate shunt;GO:0009450 gamma-aminobutyric acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38068-1", "uniprot_id": "GLRX7_YEAST", "mass": 22565.0, "length": 203, "protein_name": "Monothiol glutaredoxin-7", "gene_name": "GRX7", "organism": "Yeast", "refseq_name": "glutathione-disulfide reductase GRX7", "refseq_ac": "NP_009570", "gene_names_uniprotkb": "GRX7; GRX6; YBR0219", "gene_names_refseq": "GRX7", "protein_names_uniprotkb": "Monothiol glutaredoxin-7", "protein_names_refseq": "glutathione-disulfide reductase GRX7", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR014C)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22814378;24374639;7813418", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ16;Q1P9U2", "ec_number_list": "", "go_molecular_function": "GO:0015038 glutathione disulfide oxidoreductase activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0004362 glutathione-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0016020 membrane", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P38068-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38072-1", "uniprot_id": "SCO2_YEAST", "mass": 34889.0, "length": 301, "protein_name": "Cytochrome c oxidase assembly factor SCO2", "gene_name": "SCO2", "organism": "Yeast", "refseq_name": "putative thioredoxin peroxidase SCO2", "refseq_ac": "NP_009580", "gene_names_uniprotkb": "SCO2; YBR0308", "gene_names_refseq": "SCO2", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor SCO2", "protein_names_refseq": "putative thioredoxin peroxidase SCO2", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); mitochondrial complex IV deficiency nuclear type 4 (Disease Ontology:DOID:0070493); neurodegenerative disease (Disease Ontology:DOID:1289); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial metabolism disease (Disease Ontology:DOID:700); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (sce:YBR024W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;24374639;7813418;8091864", "class_list": "", "function": "Acts as a copper chaperone, delivering copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ26", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0034599 cellular response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38072-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38082-1", "uniprot_id": "NRG2_YEAST", "mass": 25009.0, "length": 220, "protein_name": "Probable transcriptional regulator NRG2", "gene_name": "NRG2", "organism": "Yeast", "refseq_name": "Nrg2p", "refseq_ac": "NP_009622", "gene_names_uniprotkb": "NRG2; YBR0616", "gene_names_refseq": "NRG2", "protein_names_uniprotkb": "Probable transcriptional regulator NRG2", "protein_names_refseq": "Nrg2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR066C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17322287;23749301;24374639;27821475;32597660;33491328;7813418", "class_list": "", "function": "Transcriptional repressor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ65", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043709 cell adhesion involved in single-species biofilm formation;GO:2000218 negative regulation of invasive growth in response to glucose limitation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38113-1", "uniprot_id": "ADH5_YEAST", "mass": 37648.0, "length": 351, "protein_name": "Alcohol dehydrogenase 5", "gene_name": "ADH5", "organism": "Yeast", "refseq_name": "alcohol dehydrogenase ADH5", "refseq_ac": "NP_009703", "gene_names_uniprotkb": "ADH5; YBR1122", "gene_names_refseq": "ADH5", "protein_names_uniprotkb": "Alcohol dehydrogenase 5; 1.1.1.1; Alcohol dehydrogenase V", "protein_names_refseq": "alcohol dehydrogenase ADH5", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR145W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14562106;15082781;17563356;18407956;19779198;22094012;23749301;24374639;32597660;33491328;34965436;7813418", "class_list": "", "function": "Can reduces acetaldehyde to ethanol (Probable). The role of ADH5 in yeast metabolism is not yet known, but ADH5 is not responsible for the production of ethanol during growth on glucose nor responsible for the oxidation of ethanol to acetaldehyde (PubMed:22094012)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQE0", "ec_number_list": "1.1.1.1;1.1.1.54;1.1.1.78;1.1.1.-;1.1.1.284", "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway;GO:0019655 glycolytic fermentation to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P38113-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38114-1", "uniprot_id": "TBS1_YEAST", "mass": 126904.0, "length": 1094, "protein_name": "Uncharacterized transcriptional regulatory protein TBS1", "gene_name": "TBS1", "organism": "Yeast", "refseq_name": "Tbs1p", "refseq_ac": "NP_009708", "gene_names_uniprotkb": "TBS1; YBR1133", "gene_names_refseq": "TBS1", "protein_names_uniprotkb": "Uncharacterized transcriptional regulatory protein TBS1; Thiabendazole sensitive protein 1", "protein_names_refseq": "Tbs1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR150C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10628851;14562095;14562106;14576278;18407956;19779198;23749301;24374639;33481703;33491328;7813418", "class_list": "", "function": "Involved in tolerance to thiabendazole., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQE5;E9PAD3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031965 nuclear membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38122-1", "uniprot_id": "PANB_YEAST", "mass": 34465.0, "length": 312, "protein_name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "gene_name": "ECM31", "organism": "Yeast", "refseq_name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "refseq_ac": "NP_009735", "gene_names_uniprotkb": "ECM31; YBR1238", "gene_names_refseq": "ECM31", "protein_names_uniprotkb": "3-methyl-2-oxobutanoate hydroxymethyltransferase; 2.1.2.11; Extracellular matrix protein 31; Ketopantoate hydroxymethyltransferase", "protein_names_refseq": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR176W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11154694;14562106;24374639;7813418", "class_list": "", "function": "Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase required for pantothenic acid biosynthesis (PubMed:11154694). Acts downstream in the pantothenic acid pathway (PubMed:11154694)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQH1", "ec_number_list": "2.1.2.11", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0015940 pantothenate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38122-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38125-1", "uniprot_id": "DTR1_YEAST", "mass": 63407.0, "length": 572, "protein_name": "Dityrosine transporter 1", "gene_name": "DTR1", "organism": "Yeast", "refseq_name": "Dtr1p", "refseq_ac": "NP_009739", "gene_names_uniprotkb": "DTR1; YBR1242", "gene_names_refseq": "DTR1", "protein_names_uniprotkb": "Dityrosine transporter 1", "protein_names_refseq": "Dtr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR180W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12455697;15755916;16554438;16847258;17645731;18676951;24374639;7813418", "class_list": "", "function": "Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQH4", "ec_number_list": "", "go_molecular_function": "GO:0005275 amine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0005628 prospore membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015837 amine transport;GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38126-1", "uniprot_id": "PCH2_YEAST", "mass": 63460.0, "length": 564, "protein_name": "Pachytene checkpoint protein 2", "gene_name": "PCH2", "organism": "Yeast", "refseq_name": "Pch2p", "refseq_ac": "NP_009745", "gene_names_uniprotkb": "PCH2; YBR1308", "gene_names_refseq": "PCH2", "protein_names_uniprotkb": "Pachytene checkpoint protein 2", "protein_names_refseq": "Pch2p", "tax_id": 559292, "disease": "mosaic variegated aneuploidy syndrome 3 (Disease Ontology:DOID:0080689); infertility (Disease Ontology:DOID:5223)", "pathway": " (sce:YBR186W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10319812;10734188;11502169;24374639;7813418;7871891", "class_list": "", "function": "Required for the pachytene checkpoint, the meiotic checkpoint that prevents chromosome segregation when defects in recombination and synaptonemal complex formation occurred. Represses meiotic recombination in the rDNA, probably by excluding the meiosis-specific protein HOP1 from the nucleolar region., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQI1", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0042138 meiotic DNA double-strand break formation;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38126-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38127-1", "uniprot_id": "RIM2_YEAST", "mass": 42102.0, "length": 377, "protein_name": "Mitochondrial pyrimidine nucleotide transporter RIM2", "gene_name": "RIM2", "organism": "Yeast", "refseq_name": "Rim2p", "refseq_ac": "NP_009751", "gene_names_uniprotkb": "RIM2; YBR1402", "gene_names_refseq": "PYT1; RIM2", "protein_names_uniprotkb": "Mitochondrial pyrimidine nucleotide transporter RIM2; Replication in mitochondria protein 2", "protein_names_refseq": "Rim2p", "tax_id": 559292, "disease": "familial hyperinsulinemic hypoglycemia 8 (Disease Ontology:DOID:0081328)", "pathway": " (sce:YBR192W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16194150;16823961;17322287;23800229;24374639;25320081;7813418;7891656;8346681", "class_list": "", "function": "Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:16194150). Also transports, with lower efficiency, uridine, thymidine, and cytosine (deoxy)nucleoside monophosphates as well as guanosine (deoxy)nucleoside di- and triphosphate (PubMed:16194150). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside monophosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (PubMed:16194150). Mediates the transport of iron and other divalent metal ions like copper and zinc across the mitochondrial inner membrane in a pyrimidine nucleotide-dependent fashion. Catalyzes the co-import of pyrimidine nucleotides and divalent metal ions including ferrous iron (PubMed:23800229). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:25320081)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQI6", "ec_number_list": "", "go_molecular_function": "GO:0015218 pyrimidine nucleotide transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0030001 metal ion transport;GO:0006864 pyrimidine nucleotide transport;GO:1990519 pyrimidine nucleotide import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38131-1", "uniprot_id": "KTR4_YEAST", "mass": 54556.0, "length": 464, "protein_name": "Probable mannosyltransferase KTR4", "gene_name": "KTR4", "organism": "Yeast", "refseq_name": "putative mannosyltransferase", "refseq_ac": "NP_009758", "gene_names_uniprotkb": "KTR4; YBR1411", "gene_names_refseq": "KTR4", "protein_names_uniprotkb": "Probable mannosyltransferase KTR4; 2.4.1.-", "protein_names_refseq": "putative mannosyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR199W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17322287;19779198;21126336;24374639;33491328;7813418;7975899", "class_list": "", "function": "Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQJ5;P89506", "ec_number_list": "", "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0006493 protein O-linked glycosylation;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38131-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38147-1", "uniprot_id": "CHK1_YEAST", "mass": 60017.0, "length": 527, "protein_name": "Serine/threonine-protein kinase CHK1", "gene_name": "CHK1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase CHK1", "refseq_ac": "NP_009833", "gene_names_uniprotkb": "CHK1; YBR1742", "gene_names_refseq": "CHK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase CHK1; 2.7.11.1; Checkpoint kinase 1", "protein_names_refseq": "serine/threonine protein kinase CHK1", "tax_id": 559292, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (sce:YBR274W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10550056;14562106;18407956;18984588;19411848;20489023;23749301;24374639;33491328;7813418", "class_list": "", "function": "Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Controls phosphorylation and abundance of PDS1 to prevent anaphase entry. Also helps prevent mitotic exit., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQS0", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000077 DNA damage checkpoint signaling;GO:0007095 mitotic G2 DNA damage checkpoint signaling;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38148-1", "uniprot_id": "PPS1_YEAST", "mass": 91685.0, "length": 807, "protein_name": "Dual specificity protein phosphatase PPS1", "gene_name": "PPS1", "organism": "Yeast", "refseq_name": "tyrosine/serine/threonine protein phosphatase PPS1", "refseq_ac": "NP_009835", "gene_names_uniprotkb": "PPS1; YBR2013", "gene_names_refseq": "PPS1", "protein_names_uniprotkb": "Dual specificity protein phosphatase PPS1; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "tyrosine/serine/threonine protein phosphatase PPS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR276C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17287358;21126336;23749301;24374639;32597660;33481703;33491328;7813418;8091861;9083070", "class_list": "", "function": "Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQS2", "ec_number_list": "3.1.3.16;3.1.3.48;3.1.3.43;3.1.3.2", "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0033260 nuclear DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38148-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38158-1", "uniprot_id": "MAL32_YEAST", "mass": 68142.0, "length": 584, "protein_name": "Alpha-glucosidase MAL32", "gene_name": "MAL32", "organism": "Yeast", "refseq_name": "alpha-glucosidase MAL32", "refseq_ac": "NP_009858", "gene_names_uniprotkb": "MAL32; MAL3S; YBR2117", "gene_names_refseq": "MAL32", "protein_names_uniprotkb": "Alpha-glucosidase MAL32; 3.2.1.20; Maltase", "protein_names_refseq": "alpha-glucosidase MAL32", "tax_id": 559292, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (sce:YBR299W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;24374639;7483839;7813418", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQU5", "ec_number_list": "", "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity;GO:0004556 alpha-amylase activity;GO:0004574 oligo-1,6-glucosidase activity;GO:0004575 sucrose alpha-glucosidase activity;GO:0033934 glucan 1,4-alpha-maltotriohydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0000025 maltose catabolic process;GO:0005987 sucrose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38158-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38162-1", "uniprot_id": "MIX23_YEAST", "mass": 22966.0, "length": 196, "protein_name": "Mitochondrial intermembrane space cysteine motif-containing protein MIX23", "gene_name": "MIX23", "organism": "Yeast", "refseq_name": "Mix23p", "refseq_ac": "NP_009443", "gene_names_uniprotkb": "MIX23; MIC23; YBL0805", "gene_names_refseq": "MIC23; MIX23", "protein_names_uniprotkb": "Mitochondrial intermembrane space cysteine motif-containing protein MIX23; Mitochondrial intermembrane space CX(n)C motif protein of 23 kDa", "protein_names_refseq": "Mix23p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL107C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;22984289;24374639;24687277;32826315;7502586;7813418", "class_list": "", "function": "Regulator of the mitochondrial protein import machinery that is localized in the mitochondrial intermembrane space (IMS) and facilitates the transport of proteins from the cytosol into the mitochondrial matrix (PubMed:32826315). Not essential for mitochondrial protein import but induced and required when mitochondrial import is compromised (PubMed:32826315). Stimulates or stabilizes the translocation into the mitochondria of proteins such as OXA1, ATP1 and COX12 (PubMed:32826315)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPP6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015031 protein transport;GO:1903955 positive regulation of protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38162-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38163-1", "uniprot_id": "SRO77_YEAST", "mass": 111623.0, "length": 1010, "protein_name": "Exocytosis protein SRO77", "gene_name": "SRO77", "organism": "Yeast", "refseq_name": "putative Rab GTPase-binding protein SRO77", "refseq_ac": "NP_009444", "gene_names_uniprotkb": "SRO77; SNI2; SOP2; YBL0806", "gene_names_refseq": "SNI2; SOP2; SRO77", "protein_names_uniprotkb": "Exocytosis protein SRO77; Lethal(2) giant larvae protein homolog SRO77; Sodium protection protein 2; Suppressor of RHO3 protein 77", "protein_names_refseq": "putative Rab GTPase-binding protein SRO77", "tax_id": 559292, "disease": "brain cancer (Disease Ontology:DOID:1319); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (sce:YBL106C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10402465;18407956;19779198;24374639;33481703;33491328;7502586;7813418;9691031;9837945", "class_list": "", "function": "Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPP7", "ec_number_list": "", "go_molecular_function": "GO:0045159 myosin II binding;GO:0005096 GTPase activator activity;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38163-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38175-1", "uniprot_id": "RT21_YEAST", "mass": 20395.0, "length": 177, "protein_name": "Small ribosomal subunit protein bS21m", "gene_name": "MRP21", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein bS21m MRP21", "refseq_ac": "NP_009463", "gene_names_uniprotkb": "MRP21; MRP50; YBL0702", "gene_names_refseq": "MRP21; MRP50; bS21m", "protein_names_uniprotkb": "Small ribosomal subunit protein bS21m; 37S ribosomal protein MRP21, mitochondrial", "protein_names_refseq": "mitochondrial 37S ribosomal protein bS21m MRP21", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL090W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12392552;14562095;14562106;14576278;17322287;24374639;25609543;28154081;7502586;7813418;9528754", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPR4", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070124 mitochondrial translational initiation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38175-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38179-1", "uniprot_id": "ALG3_YEAST", "mass": 52861.0, "length": 458, "protein_name": "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase", "gene_name": "ALG3", "organism": "Yeast", "refseq_name": "dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase", "refseq_ac": "NP_009471", "gene_names_uniprotkb": "ALG3; RHK1; YBL0720", "gene_names_refseq": "ALG3; RHK1", "protein_names_uniprotkb": "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; 2.4.1.258; Asparagine-linked glycosylation protein 3; Dol-P-Man-dependent alpha(1-3)-mannosyltransferase; Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase; HM-1 killer toxin resistance protein", "protein_names_refseq": "dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase", "tax_id": 559292, "disease": "congenital disorder of glycosylation Id (Disease Ontology:DOID:0080556); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (sce:YBL082C); (R-SCE-446193)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11308030;16847258;22814378;24374639;33481703;33491328;7502586;7754714;7813418;8842708;9108275", "class_list": "", "function": "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPS1", "ec_number_list": "2.4.1.258", "go_molecular_function": "GO:0052925 dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006488 dolichol-linked oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38179-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38187-1", "uniprot_id": "UBP13_YEAST", "mass": 83856.0, "length": 747, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 13", "gene_name": "UBP13", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP13", "refseq_ac": "NP_009486", "gene_names_uniprotkb": "UBP13; YBL0621", "gene_names_refseq": "UBP13", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 13; 3.4.19.12; Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13", "protein_names_refseq": "ubiquitin-specific protease UBP13", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL067C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12748633;14562106;17287358;17563356;18407956;19779198;20702584;21177495;23749301;24374639;31208443;32597660;33481703;33491328;34965436;7813418", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPT4", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0010995 free ubiquitin chain depolymerization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38187-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38196-1", "uniprot_id": "FUI1_YEAST", "mass": 72165.0, "length": 639, "protein_name": "Uridine permease", "gene_name": "FUI1", "organism": "Yeast", "refseq_name": "uridine permease", "refseq_ac": "NP_009511", "gene_names_uniprotkb": "FUI1; YBL0406", "gene_names_refseq": "FUI1", "protein_names_uniprotkb": "Uridine permease", "protein_names_refseq": "uridine permease", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL042C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10827169;16847258;17330950;18407956;19779198;19795423;19823750;20702584;22106047;23749301;24374639;32597660;33481703;33491328;7813418;7871888;9485596", "class_list": "", "function": "High-affinity transport of uridine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPV6", "ec_number_list": "", "go_molecular_function": "GO:0015205 nucleobase transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0015851 nucleobase transport;GO:0015862 uridine transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38196-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38200-1", "uniprot_id": "SHE1_YEAST", "mass": 38015.0, "length": 338, "protein_name": "Mitotic spindle-associated protein SHE1", "gene_name": "SHE1", "organism": "Yeast", "refseq_name": "She1p", "refseq_ac": "NP_009522", "gene_names_uniprotkb": "SHE1; YBL0420", "gene_names_refseq": "SHE1", "protein_names_uniprotkb": "Mitotic spindle-associated protein SHE1; Sensitive to high expression protein 1", "protein_names_refseq": "She1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL031W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;17287358;17322287;17634282;19779198;21177495;23749301;24374639;32597660;33481703;33491328;7725803;7762298;7813418", "class_list": "", "function": "May have a role related to the spindle integrity function of the DAM1 complex, which is essential for proper chromosome segregation. Causes growth arrest when highly overexpressed., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPW8", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0070840 dynein complex binding;GO:0140661 cytoskeletal motor inhibitor activity", "go_cellular_component": "GO:0015630 microtubule cytoskeleton;GO:0072686 mitotic spindle;GO:0005880 nuclear microtubule;GO:0005935 cellular bud neck", "go_biological_process": "GO:0051301 cell division;GO:0040001 establishment of mitotic spindle localization;GO:0000022 mitotic spindle elongation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38200-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38204-1", "uniprot_id": "RRN10_YEAST", "mass": 16505.0, "length": 145, "protein_name": "RNA polymerase I-specific transcription initiation factor RRN10", "gene_name": "RRN10", "organism": "Yeast", "refseq_name": "Rrn10p", "refseq_ac": "NP_009528", "gene_names_uniprotkb": "RRN10; YBL0426", "gene_names_refseq": "RRN10", "protein_names_uniprotkb": "RNA polymerase I-specific transcription initiation factor RRN10", "protein_names_refseq": "Rrn10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL025W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;17322287;24374639;7725803;7813418;8846924;9837969", "class_list": "", "function": "Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPX5", "ec_number_list": "", "go_molecular_function": "GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000500 RNA polymerase I upstream activating factor complex", "go_biological_process": "GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38204-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38218-1", "uniprot_id": "POA1_YEAST", "mass": 19938.0, "length": 177, "protein_name": "ADP-ribose 1''-phosphate phosphatase", "gene_name": "POA1", "organism": "Yeast", "refseq_name": "ADP-ribose 1''-phosphate phosphatase", "refseq_ac": "NP_009578", "gene_names_uniprotkb": "POA1; YBR0304", "gene_names_refseq": "POA1", "protein_names_uniprotkb": "ADP-ribose 1''-phosphate phosphatase; 3.1.3.84; 3.2.2.-; [Protein ADP-ribosylglutamate] hydrolase", "protein_names_refseq": "ADP-ribose 1''-phosphate phosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR022W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10550052;14562106;15684411;15902274;17322287;18407956;23474712;24374639;33491328;7813418;8091864", "class_list": "", "function": "Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ24", "ec_number_list": "3.2.2.-;3.1.3.84", "go_molecular_function": "GO:0016791 phosphatase activity;GO:0047407 ADP-ribosyl-[dinitrogen reductase] hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0042278 purine nucleoside metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38219-1", "uniprot_id": "OLA1_YEAST", "mass": 44174.0, "length": 394, "protein_name": "Obg-like ATPase 1", "gene_name": "OLA1", "organism": "Yeast", "refseq_name": "Obg-like ATPase", "refseq_ac": "NP_009581", "gene_names_uniprotkb": "OLA1; YBR0309", "gene_names_refseq": "OLA1", "protein_names_uniprotkb": "Obg-like ATPase 1", "protein_names_refseq": "Obg-like ATPase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR025C); (R-SCE-114608)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10684247;14562095;14562106;15665377;16284124;17430889;18407956;19779198;20702584;21126336;22106047;22842922;23749301;24374639;32597660;33481703;33491328;7813418;8091864;9712873", "class_list": "", "function": "Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ27", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:1900036 positive regulation of cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38219-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38222-1", "uniprot_id": "RKM3_YEAST", "mass": 62594.0, "length": 552, "protein_name": "Ribosomal lysine N-methyltransferase 3", "gene_name": "RKM3", "organism": "Yeast", "refseq_name": "protein-lysine N-methyltransferase", "refseq_ac": "NP_009586", "gene_names_uniprotkb": "RKM3; YBR0314", "gene_names_refseq": "RKM3", "protein_names_uniprotkb": "Ribosomal lysine N-methyltransferase 3; 2.1.1.-", "protein_names_refseq": "protein-lysine N-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR030W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;18957409;24374639;24517342;33491328;7813418;8091864", "class_list": "", "function": "S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-40'., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ31", "ec_number_list": "", "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0018026 peptidyl-lysine monomethylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38222-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38224-1", "uniprot_id": "FIG1_YEAST", "mass": 33776.0, "length": 298, "protein_name": "Factor-induced gene 1 protein", "gene_name": "FIG1", "organism": "Yeast", "refseq_name": "Fig1p", "refseq_ac": "NP_009596", "gene_names_uniprotkb": "FIG1; YBR0410", "gene_names_refseq": "FIG1", "protein_names_uniprotkb": "Factor-induced gene 1 protein", "protein_names_refseq": "Fig1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR040W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15087486;17322287;17330950;24374639;33481703;33491328;7813418", "class_list": "", "function": "Required for efficient mating., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ40;Q70DD9;Q70DE0;Q70DE1;Q70DE3;Q70DE4;Q70DE5;Q70DE6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall;GO:0043332 mating projection tip", "go_biological_process": "GO:0000747 conjugation with cellular fusion;GO:0000753 cell morphogenesis involved in conjugation with cellular fusion;GO:0000755 cytogamy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38224-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38226-1", "uniprot_id": "CST26_YEAST", "mass": 45515.0, "length": 397, "protein_name": "2-acyl-1-lysophosphatidylinositol acyltransferase", "gene_name": "CST26", "organism": "Yeast", "refseq_name": "putative acyltransferase", "refseq_ac": "NP_009598", "gene_names_uniprotkb": "CST26; PSI1; YBR0412", "gene_names_refseq": "CST26; PSI1", "protein_names_uniprotkb": "2-acyl-1-lysophosphatidylinositol acyltransferase; 2.3.-.-; Acyl-CoA:lyso-PI acyltransferase; Chromosome stability protein 26; Phosphatidylinositol stearoyl incorporating protein 1", "protein_names_refseq": "putative acyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR042C); (R-SCE-1482798); (R-SCE-1482925); (R-SCE-1483166)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10454593;14562095;14562106;15716577;19796168;20694142;22323296;24374639;26711260;27462707;33491328;7813418", "class_list": "", "function": "Acyltransferase with lysophosphatidic acid acyltransferase (LPAAT) activity. Fatty acyl substrates include 18:0-acyl-CoA, 16:0-acyl-CoA, 17:0-acyl-CoA and 14:0-acyl-CoA (PubMed:20694142). Responsible for the acyl-CoA-dependent introduction of saturated very long chain fatty acids (VLCFAs) into phosphatidylinositol, transferring saturated FAs with 18 to 26 carbon atoms (PubMed:27462707). Responsible for the incorporation of stearate into phosphatidylinositol (PubMed:19796168, PubMed:26711260). Overexpression has an effect on chromosome stability (PubMed:10454593). Regulates phosphorylation and expression of glycerol-3-phosphate acyltransferase SCT1 (PubMed:22323296)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ42", "ec_number_list": "2.3.1.51;2.3.1.23;2.3.1.n7;2.3.-.-", "go_molecular_function": "GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0012505 endomembrane system", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0036149 phosphatidylinositol acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38226-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38227-1", "uniprot_id": "QDR3_YEAST", "mass": 77287.0, "length": 689, "protein_name": "Quinidine resistance protein 3", "gene_name": "QDR3", "organism": "Yeast", "refseq_name": "Qdr3p", "refseq_ac": "NP_009599", "gene_names_uniprotkb": "QDR3; AQR2; YBR0413", "gene_names_refseq": "AQR2; QDR3", "protein_names_uniprotkb": "Quinidine resistance protein 3; Acids quinidine resistance protein 2", "protein_names_refseq": "Qdr3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR043C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;15649438;16847258;18407956;19779198;21126336;21177495;22218487;22814378;23749301;24374639;24440502;32597660;33481703;33491328;7813418", "class_list": "", "function": "Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ43", "ec_number_list": "", "go_molecular_function": "GO:0015562 efflux transmembrane transporter activity;GO:0015203 polyamine transmembrane transporter activity;GO:0015565 threonine efflux transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0055085 transmembrane transport;GO:0010509 intracellular polyamine homeostasis;GO:0032973 amino acid export across plasma membrane;GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38227-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38241-1", "uniprot_id": "SLT11_YEAST", "mass": 40925.0, "length": 364, "protein_name": "Pre-mRNA-splicing factor SLT11", "gene_name": "ECM2", "organism": "Yeast", "refseq_name": "Pre-mRNA-splicing factor ECM2", "refseq_ac": "NP_009621", "gene_names_uniprotkb": "ECM2; SLT11; YBR0614", "gene_names_refseq": "ECM2; SLT11", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SLT11; Extracellular mutant protein 2; Synthetic lethality with U2 protein 11", "protein_names_refseq": "Pre-mRNA-splicing factor ECM2", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR065C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11158289;11884590;14562095;14562106;14690591;17287358;18407956;21126336;24374639;33491328;7813418;9528778", "class_list": "", "function": "Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ64;P89497", "ec_number_list": "", "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0000974 Prp19 complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38241-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38254-1", "uniprot_id": "TTL_YEAST", "mass": 86353.0, "length": 753, "protein_name": "Probable tubulin--tyrosine ligase PBY1", "gene_name": "PBY1", "organism": "Yeast", "refseq_name": "putative tubulin tyrosine ligase", "refseq_ac": "NP_009652", "gene_names_uniprotkb": "PBY1; YBR0821", "gene_names_refseq": "PBY1", "protein_names_uniprotkb": "Probable tubulin--tyrosine ligase PBY1; 6.3.2.25; P-body-associated protein 1", "protein_names_refseq": "putative tubulin tyrosine ligase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR094W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;17307817;18407956;21126336;23749301;24374639;33481703;33491328;7813418;7900426", "class_list": "", "function": "Probable P-body-associated tubulin--tyrosine ligase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ95", "ec_number_list": "6.3.2.25", "go_molecular_function": "GO:0004835 tubulin-tyrosine ligase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38254-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38278-1", "uniprot_id": "BMT2_YEAST", "mass": 38550.0, "length": 337, "protein_name": "25S rRNA (adenine(2142)-N(1))-methyltransferase", "gene_name": "BMT2", "organism": "Yeast", "refseq_name": "25S rRNA (adenine2142-N1)-methyltransferase", "refseq_ac": "NP_009699", "gene_names_uniprotkb": "BMT2; YBR1118", "gene_names_refseq": "BMT2", "protein_names_uniprotkb": "25S rRNA (adenine(2142)-N(1))-methyltransferase; 2.1.1.286; Base MethylTransferase of 25S RNA", "protein_names_refseq": "25S rRNA (adenine2142-N1)-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR141C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;23558746;24374639;7754712;7813418", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQD7", "ec_number_list": "2.1.1.286", "go_molecular_function": "GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0016433 rRNA (adenine) methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38278-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38279-1", "uniprot_id": "YPQ3_YEAST", "mass": 33497.0, "length": 296, "protein_name": "Vacuolar histidine transporter YPQ3", "gene_name": "RTC2", "organism": "Yeast", "refseq_name": "cationic amino acid transporter", "refseq_ac": "NP_009705", "gene_names_uniprotkb": "RTC2; YBR1124; YPQ3", "gene_names_refseq": "RRT11; RTC2; YPQ3", "protein_names_uniprotkb": "Vacuolar histidine transporter YPQ3; PQ-loop repeat-containing protein 3; Protein RTC2; Restriction of telomere capping protein 2", "protein_names_refseq": "cationic amino acid transporter", "tax_id": 559292, "disease": "lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (sce:YBR147W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12702675;15388447;16823961;16847258;17986253;18845848;23169667;24374639;26928127;32776922;7813418", "class_list": "", "function": "Amino acid transporter that moves histidine into the vacuole (PubMed:26928127). May also contribute to low affinity arginine import into the vacuole (PubMed:32776922). May function as an amino acid/proton antiporter (PubMed:26928127)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQE2", "ec_number_list": "", "go_molecular_function": "GO:0015174 basic amino acid transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0034488 basic amino acid transmembrane export from vacuole;GO:0090513 L-histidine transmembrane import into vacuole", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38279-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38282-1", "uniprot_id": "SP381_YEAST", "mass": 33772.0, "length": 291, "protein_name": "Pre-mRNA-splicing factor SPP381", "gene_name": "SPP381", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit SPP381", "refseq_ac": "NP_009710", "gene_names_uniprotkb": "SPP381; YBR1202", "gene_names_refseq": "SPP381", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SPP381; Suppressor of PRP38-1 mutation", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit SPP381", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR152W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10449419;11804584;14562095;14562106;17322287;18407956;23749301;24374639;33491328;7813418;9858581", "class_list": "", "function": "Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQE7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38282-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38293-1", "uniprot_id": "UMP1_YEAST", "mass": 16760.0, "length": 148, "protein_name": "Proteasome maturation factor UMP1", "gene_name": "UMP1", "organism": "Yeast", "refseq_name": "Ump1p", "refseq_ac": "NP_009732", "gene_names_uniprotkb": "UMP1; YBR1234", "gene_names_refseq": "RNS2; UMP1", "protein_names_uniprotkb": "Proteasome maturation factor UMP1", "protein_names_refseq": "Ump1p", "tax_id": 559292, "disease": "proteosome-associated autoinflammatory syndrome 2 (Disease Ontology:DOID:0060914)", "pathway": " (sce:YBR173C); (R-SCE-9907900)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;17322287;18407956;24374639;33481703;33491328;7813418;9491890", "class_list": "", "function": "Short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. Required for the correct assembly and enzymatic activation of the proteasome. Also prevents premature processing of the PRE2 propeptide., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQG9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38293-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38300-1", "uniprot_id": "MBA1_YEAST", "mass": 31811.0, "length": 278, "protein_name": "Inner membrane mitoribosome receptor MBA1, mitochondrial", "gene_name": "MBA1", "organism": "Yeast", "refseq_name": "Mba1p", "refseq_ac": "NP_009744", "gene_names_uniprotkb": "MBA1; YBR1307", "gene_names_refseq": "MBA1", "protein_names_uniprotkb": "Inner membrane mitoribosome receptor MBA1, mitochondrial; Multi-copy bypass of AFG3 protein", "protein_names_refseq": "Mba1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR185C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11381092;14562106;16601683;17322287;18727146;20404317;20427570;24374639;25609543;7813418;7871891;8690083", "class_list": "", "function": "Mitochondrial inner membrane-associated mitoribosome receptor that spatially aligns the mitoribosome exit tunnel with the membrane insertion machinery and allows cotranslational protein membrane insertion., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQI0", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding;GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070131 positive regulation of mitochondrial translation;GO:0007007 inner mitochondrial membrane organization;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38300-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38324-1", "uniprot_id": "SLX1_YEAST", "mass": 35857.0, "length": 304, "protein_name": "Structure-specific endonuclease subunit SLX1", "gene_name": "SLX1", "organism": "Yeast", "refseq_name": "endonuclease", "refseq_ac": "NP_009787", "gene_names_uniprotkb": "SLX1; YBR1525", "gene_names_refseq": "SLX1", "protein_names_uniprotkb": "Structure-specific endonuclease subunit SLX1; 3.1.-.-; Synthetic lethal of unknown function protein 1", "protein_names_refseq": "endonuclease", "tax_id": 559292, "disease": "Fanconi-like syndrome (Disease Ontology:DOID:0090066)", "pathway": " (sce:YBR228W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11139495;12832395;24374639;7813418", "class_list": "", "function": "Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQM3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0017108 5'-flap endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000228 nuclear chromosome;GO:0033557 Slx1-Slx4 complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0000724 double-strand break repair via homologous recombination;GO:0006261 DNA-templated DNA replication;GO:1902681 regulation of replication fork arrest at rDNA repeats", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38326-1", "uniprot_id": "SWC5_YEAST", "mass": 34344.0, "length": 303, "protein_name": "SWR1-complex protein 5", "gene_name": "SWC5", "organism": "Yeast", "refseq_name": "Swc5p", "refseq_ac": "NP_009790", "gene_names_uniprotkb": "SWC5; AOR1; YBR1529", "gene_names_refseq": "AOR1; SWC5", "protein_names_uniprotkb": "SWR1-complex protein 5", "protein_names_refseq": "Swc5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR231C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;14645854;14690608;15045029;17287358;19779198;19795423;19823750;23749301;24374639;33481703;33491328;7813418", "class_list": "", "function": "Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQM7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38326-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38331-1", "uniprot_id": "YB92_YEAST", "mass": 27577.0, "length": 238, "protein_name": "5'-deoxynucleotidase YBR242W", "gene_name": "YBR1627", "organism": "Yeast", "refseq_name": "5'-deoxynucleotidase", "refseq_ac": "NP_009801", "gene_names_uniprotkb": "YBR1627", "gene_names_refseq": "", "protein_names_uniprotkb": "5'-deoxynucleotidase YBR242W; 3.1.3.89", "protein_names_refseq": "5'-deoxynucleotidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR242W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;17322287;24374639;29752939;33491328;7813418", "class_list": "", "function": "Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQN8", "ec_number_list": "3.1.3.89", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0002953 5'-deoxynucleotidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009159 deoxyribonucleoside monophosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38331-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38347-1", "uniprot_id": "EFM2_YEAST", "mass": 47977.0, "length": 419, "protein_name": "Protein-lysine N-methyltransferase EFM2", "gene_name": "EFM2", "organism": "Yeast", "refseq_name": "S-adenosylmethionine-dependent methyltransferase", "refseq_ac": "NP_009830", "gene_names_uniprotkb": "EFM2; YBR1739", "gene_names_refseq": "EFM2", "protein_names_uniprotkb": "Protein-lysine N-methyltransferase EFM2; 2.1.1.-; Elongation factor methyltransferase 2", "protein_names_refseq": "S-adenosylmethionine-dependent methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR271W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;17322287;19779198;21858014;22522802;24374639;24517342;25086354;25231983;33491328;7813418", "class_list": "", "function": "S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 2 (EFT1/EFT2) at 'Lys-613' and methylates elongation factor 3A (YEF3)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQR7", "ec_number_list": "", "go_molecular_function": "GO:0008276 protein methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation;GO:0045905 positive regulation of translational termination", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38359-1", "uniprot_id": "SUL1_YEAST", "mass": 95951.0, "length": 859, "protein_name": "Sulfate permease 1", "gene_name": "SUL1", "organism": "Yeast", "refseq_name": "sulfate permease", "refseq_ac": "NP_009853", "gene_names_uniprotkb": "SUL1; SFP2; YBR2110", "gene_names_refseq": "SFP2; SUL1", "protein_names_uniprotkb": "Sulfate permease 1; High-affinity sulfate transporter 1", "protein_names_refseq": "sulfate permease", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR294W); (R-SCE-174362); (R-SCE-427601)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17322287;24374639;7616962;7677785;7813418;9055073", "class_list": "", "function": "High affinity uptake of sulfate into the cell., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VQT8", "ec_number_list": "", "go_molecular_function": "GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38616-1", "uniprot_id": "YGP1_YEAST", "mass": 37328.0, "length": 354, "protein_name": "Protein YGP1", "gene_name": "YGP1", "organism": "Yeast", "refseq_name": "Ygp1p", "refseq_ac": "NP_014239", "gene_names_uniprotkb": "YGP1; N1731", "gene_names_refseq": "YGP1", "protein_names_uniprotkb": "Protein YGP1; GP38", "protein_names_refseq": "Ygp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL160W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10234784;18434410;19795423;19823750;24374639;33491328;8139573;8686380;9169873", "class_list": "", "function": "May be involved in cellular adaptations prior to stationary phase., [UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6W123", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0070726 cell wall assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38616-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38622-1", "uniprot_id": "RCK1_YEAST", "mass": 57981.0, "length": 512, "protein_name": "Serine/threonine-protein kinase RCK1", "gene_name": "RCK1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase RCK1", "refseq_ac": "NP_011357", "gene_names_uniprotkb": "RCK1; G1854", "gene_names_refseq": "RCK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase RCK1; 2.7.11.1", "protein_names_refseq": "putative serine/threonine protein kinase RCK1", "tax_id": 559292, "disease": "dyslexia (Disease Ontology:DOID:4428)", "pathway": " (sce:YGL158W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17322287;20489023;24374639;33491328;8112585;8585324;9169869", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTZ3", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0034599 cellular response to oxidative stress;GO:0040020 regulation of meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38622-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38625-1", "uniprot_id": "GUAA_YEAST", "mass": 58482.0, "length": 525, "protein_name": "GMP synthase [glutamine-hydrolyzing]", "gene_name": "GUA1", "organism": "Yeast", "refseq_name": "GMP synthase (glutamine-hydrolyzing)", "refseq_ac": "NP_013944", "gene_names_uniprotkb": "GUA1; YM8261.11", "gene_names_refseq": "GUA1", "protein_names_uniprotkb": "GMP synthase [glutamine-hydrolyzing]; 6.3.5.2; GMP synthetase; Glutamine amidotransferase", "protein_names_refseq": "GMP synthase (glutamine-hydrolyzing)", "tax_id": 559292, "disease": "acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YMR217W); (R-SCE-73817); (R-SCE-9748787)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "18407956;21126336;22106047;23749301;24374639;32597660;33481703;33491328;7483834;8112582;9169872", "class_list": "", "function": "Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W042", "ec_number_list": "6.3.5.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0003921 GMP synthase activity;GO:0003922 GMP synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006177 GMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38625-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38636-1", "uniprot_id": "ATX1_YEAST", "mass": 8221.0, "length": 73, "protein_name": "Copper chaperone ATX1", "gene_name": "ATX1", "organism": "Yeast", "refseq_name": "copper metallochaperone ATX1", "refseq_ac": "NP_014140", "gene_names_uniprotkb": "ATX1; N0840", "gene_names_refseq": "ATX1", "protein_names_uniprotkb": "Copper chaperone ATX1; Antioxidant protein 1; Metal homeostasis protein ATX1", "protein_names_refseq": "copper metallochaperone ATX1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL259C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10404590;11327811;16732294;17322287;19965379;24374639;28865724;7731983;9083054;9169873;9234673;9346482", "class_list": "", "function": "Copper homeostasis factor that specifically transports copper to the secretory pathway for incorporation into copper enzymes destined for the cell surface or extracellular milieu (PubMed:9346482). Shuttles copper to the transport ATPase CCC2 on a post-Golgi vesicle for eventual targeting to the cell-surface high-affinity iron uptake protein FET3 (PubMed:11327811, PubMed:16732294, PubMed:9083054, PubMed:9346482). Protects against oxygen toxicity (PubMed:7731983)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0T4;E9P8W0", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0034599 cellular response to oxidative stress;GO:0006825 copper ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38636-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38682-1", "uniprot_id": "GLO3_YEAST", "mass": 55094.0, "length": 493, "protein_name": "ADP-ribosylation factor GTPase-activating protein GLO3", "gene_name": "GLO3", "organism": "Yeast", "refseq_name": "ADP-ribosylation factor GTPase-activating protein", "refseq_ac": "NP_011048", "gene_names_uniprotkb": "GLO3", "gene_names_refseq": "GLO3", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein GLO3; ARF GAP GLO3", "protein_names_refseq": "ADP-ribosylation factor GTPase-activating protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YER122C); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 25, "publication_id_list": "14562095;14562106;15665377;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;30516470;31331965;32597660;33481703;33491328;8070409;9169868;9927415", "class_list": "", "function": "GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM28", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030137 COPI-coated vesicle;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38682-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38687-1", "uniprot_id": "SRP68_YEAST", "mass": 69006.0, "length": 599, "protein_name": "Signal recognition particle subunit SRP68", "gene_name": "SRP68", "organism": "Yeast", "refseq_name": "signal recognition particle subunit SRP68", "refseq_ac": "NP_015081", "gene_names_uniprotkb": "SRP68", "gene_names_refseq": "SRP68", "protein_names_uniprotkb": "Signal recognition particle subunit SRP68; Signal recognition particle 68 kDa protein homolog", "protein_names_refseq": "signal recognition particle subunit SRP68", "tax_id": 559292, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590)", "pathway": " (sce:YPL243W); (R-SCE-1799339)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11352936;14562106;19779198;21177495;22814378;23749301;24374639;33481703;33491328;7925282;9169875", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:7925282). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (PubMed:7925282)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3C8", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0030942 endoplasmic reticulum signal peptide binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0034399 nuclear periphery", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38688-1", "uniprot_id": "SRP72_YEAST", "mass": 73541.0, "length": 640, "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "SRP72", "organism": "Yeast", "refseq_name": "signal recognition particle subunit SRP72", "refseq_ac": "NP_015114", "gene_names_uniprotkb": "SRP72", "gene_names_refseq": "SRP72", "protein_names_uniprotkb": "Signal recognition particle subunit SRP72; Signal recognition particle 72 kDa protein homolog", "protein_names_refseq": "signal recognition particle subunit SRP72", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL210C); (R-SCE-1799339)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10921896;11352936;12748633;14562095;14562106;18407956;24374639;33481703;33491328;7925282;9169875", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:10921896, PubMed:7925282). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:10921896, PubMed:7925282). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds signal recognition particle RNA (7SL RNA) in presence of SRP68 (By similarity). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (PubMed:10921896)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3G0", "ec_number_list": "", "go_molecular_function": "GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005730 nucleolus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38688-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38698-1", "uniprot_id": "PPX1_YEAST", "mass": 45051.0, "length": 397, "protein_name": "Polyphosphatase", "gene_name": "PPX1", "organism": "Yeast", "refseq_name": "exopolyphosphatase", "refseq_ac": "NP_012071", "gene_names_uniprotkb": "PPX1", "gene_names_refseq": "PPX1", "protein_names_uniprotkb": "Polyphosphatase; 3.6.1.11; Exopolyphosphatase; Metaphosphatase; PolyPase", "protein_names_refseq": "exopolyphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR201C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;17599355;24374639;31175919;33491328;7860598;8091229", "class_list": "", "function": "Polyphosphatase (polyPase) involved in the degradation of inorganic polyphosphates (polyP) that is able to degrade a range of chains from three to several hundreds of residues in a highly processive manner (PubMed:7860598). Exclusively shows exopolyphosphatase activity, cleaving inside the polyP chain (PubMed:31175919)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLF0", "ec_number_list": "3.6.1.11;3.6.1.-;3.6.1.10", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004309 exopolyphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006798 polyphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38698-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38699-1", "uniprot_id": "STB5_YEAST", "mass": 83473.0, "length": 743, "protein_name": "Protein STB5", "gene_name": "STB5", "organism": "Yeast", "refseq_name": "Stb5p", "refseq_ac": "NP_012048", "gene_names_uniprotkb": "STB5", "gene_names_refseq": "STB5", "protein_names_uniprotkb": "Protein STB5", "protein_names_refseq": "Stb5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR178W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;18407956;23749301;24374639;32597660;33481703;33491328;8091229;9393435", "class_list": "", "function": "Binds to SIN3., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLC7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034599 cellular response to oxidative stress;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38699-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38705-1", "uniprot_id": "SYSM_YEAST", "mass": 50390.0, "length": 446, "protein_name": "Serine--tRNA ligase, mitochondrial", "gene_name": "DIA4", "organism": "Yeast", "refseq_name": "putative serine--tRNA ligase DIA4", "refseq_ac": "NP_011875", "gene_names_uniprotkb": "DIA4", "gene_names_refseq": "DIA4", "protein_names_uniprotkb": "Serine--tRNA ligase, mitochondrial; 6.1.1.11; Digs into agar protein 4; SerRS; Seryl-tRNA synthetase; Seryl-tRNA(Ser) synthetase", "protein_names_refseq": "putative serine--tRNA ligase DIA4", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR011W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562095;14562106;17322287;24374639;8091229", "class_list": "", "function": "Catalyzes the attachment of serine to tRNA(Ser) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV6", "ec_number_list": "6.1.1.11", "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004828 serine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070158 mitochondrial seryl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P38705-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38724-1", "uniprot_id": "ARN2_YEAST", "mass": 69566.0, "length": 620, "protein_name": "Siderophore iron transporter ARN2", "gene_name": "ARN2", "organism": "Yeast", "refseq_name": "siderophore transporter", "refseq_ac": "NP_011816", "gene_names_uniprotkb": "ARN2; TAF1", "gene_names_refseq": "ARN2; TAF1", "protein_names_uniprotkb": "Siderophore iron transporter ARN2; Triacetylfusarinine C permease; Triacetylfusarinine C transporter 1", "protein_names_refseq": "siderophore transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL047C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10744769;10816729;24374639;8091229", "class_list": "", "function": "Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKS4", "ec_number_list": "", "go_molecular_function": "GO:0015343 siderophore-iron transmembrane transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0005774 vacuolar membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0015891 siderophore transport;GO:0009237 siderophore metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38724-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38727-1", "uniprot_id": "YHE4_YEAST", "mass": 26972.0, "length": 235, "protein_name": "DUP240 protein DFP4", "gene_name": "DFP4", "organism": "Yeast", "refseq_name": "DUP240 family protein", "refseq_ac": "NP_011819", "gene_names_uniprotkb": "DFP4", "gene_names_refseq": "DFP4", "protein_names_uniprotkb": "DUP240 protein DFP4", "protein_names_refseq": "DUP240 family protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL044W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11283351;12101299;15087486;16847258;24374639;8091229", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKS6;Q70D60;Q70DF5;Q70DF7;Q70DF9;Q70DG3;Q70DG4;Q70DG5;Q70DG6;Q70DG7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38727-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38735-1", "uniprot_id": "VMR1_YEAST", "mass": 180926.0, "length": 1592, "protein_name": "ABC transporter ATP-binding protein/permease VMR1", "gene_name": "VMR1", "organism": "Yeast", "refseq_name": "putative ATP-binding cassette multidrug transporter VMR1", "refseq_ac": "NP_011828", "gene_names_uniprotkb": "VMR1", "gene_names_refseq": "VMR1", "protein_names_uniprotkb": "ABC transporter ATP-binding protein/permease VMR1; Vacuolar multidrug resistance protein 1", "protein_names_refseq": "putative ATP-binding cassette multidrug transporter VMR1", "tax_id": 559292, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); stroke (Disease Ontology:DOID:0051061); hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); transient neonatal diabetes mellitus 2 (Disease Ontology:DOID:0061174); familial hyperinsulinemic hypoglycemia 1 (Disease Ontology:DOID:0070219); intellectual disability and myopathy syndrome (Disease Ontology:DOID:0070600); dilated cardiomyopathy 1O (Disease Ontology:DOID:0110451); leucine-sensitive hypoglycemia of infancy (Disease Ontology:DOID:0112262); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YHL035C); (R-SCE-382556); (R-SCE-8856825)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12756250;15886332;15942929;24374639;33491328;8091229;9020838", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DKT3", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0010038 response to metal ion;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38737-1", "uniprot_id": "ECM29_YEAST", "mass": 210431.0, "length": 1868, "protein_name": "Proteasome component ECM29", "gene_name": "ECM29", "organism": "Yeast", "refseq_name": "Ecm29p", "refseq_ac": "NP_011833", "gene_names_uniprotkb": "ECM29", "gene_names_refseq": "ECM29", "protein_names_uniprotkb": "Proteasome component ECM29; Extracellular mutant protein 29", "protein_names_refseq": "Ecm29p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL030W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12408819;14562095;14562106;18407956;21126336;22814378;24374639;33481703;33491328;8091229;9335584", "class_list": "", "function": "Stabilizes the proteasome holoenzyme, probably by tethering the 20S proteolytic core particle and the 19S regulatory particle. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKT8", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000502 proteasome complex", "go_biological_process": "GO:0036503 ERAD pathway;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38737-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38748-1", "uniprot_id": "ETP1_YEAST", "mass": 67503.0, "length": 585, "protein_name": "RING finger protein ETP1", "gene_name": "ETP1", "organism": "Yeast", "refseq_name": "Etp1p", "refseq_ac": "NP_011853", "gene_names_uniprotkb": "ETP1", "gene_names_refseq": "ETP1", "protein_names_uniprotkb": "RING finger protein ETP1; BRAP2 homolog; Ethanol tolerance protein 1", "protein_names_refseq": "Etp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL010C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12872131;14557538;17322287;19416103;19779198;22106047;23749301;24374639;33491328;8091229", "class_list": "", "function": "May act as a cytoplasmic retention protein with a role in regulating nuclear transport. Binds nuclear localization sequences in vitro. Needed to adapt efficiently to ethanol, either as sole carbon source or as cell stressor. Involved in ethanol-dependent transcriptional activation of several genes and ethanol-induced protein turnover of some proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKQ3;Q6Q5F9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043130 ubiquitin binding;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045471 response to ethanol;GO:0007265 Ras protein signal transduction;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38748-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38749-1", "uniprot_id": "YAP3_YEAST", "mass": 37955.0, "length": 330, "protein_name": "AP-1-like transcription factor YAP3", "gene_name": "YAP3", "organism": "Yeast", "refseq_name": "Yap3p", "refseq_ac": "NP_011854", "gene_names_uniprotkb": "YAP3", "gene_names_refseq": "YAP3", "protein_names_uniprotkb": "AP-1-like transcription factor YAP3", "protein_names_refseq": "Yap3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL009C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11561289;11957110;14562095;14562106;18407956;19779198;19795423;19823750;20702584;21177495;23749301;24374639;32597660;33481703;33491328;8091229;9372930;9864335", "class_list": "", "function": "Transcription activator involved in the regulation of genes expressed in response to environmental changes. When overexpressed it activates transcription of the multidrug resistance ABC transporter PDR5, thus conferring resistance to the fungicide fluconazole (FCZ) and cycloheximide. When overexpressed, it also confers, independent of PDR5, increased resistance to 4-nitroquinoline-N-oxide (4-NQO) (By similarity). Preferentially binds 5'-TTACTAA-3'., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKQ4", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P38749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38819-1", "uniprot_id": "ERP5_YEAST", "mass": 24249.0, "length": 212, "protein_name": "Protein ERP5", "gene_name": "ERP5", "organism": "Yeast", "refseq_name": "Erp5p", "refseq_ac": "NP_011978", "gene_names_uniprotkb": "ERP5", "gene_names_refseq": "ERP5", "protein_names_uniprotkb": "Protein ERP5", "protein_names_refseq": "Erp5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR110W); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10359606;16847258;24374639;8091229", "class_list": "", "function": "Involved in vesicular protein trafficking., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL60", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38871-1", "uniprot_id": "SSP1_YEAST", "mass": 65815.0, "length": 571, "protein_name": "Sporulation-specific protein 1", "gene_name": "SSP1", "organism": "Yeast", "refseq_name": "Ssp1p", "refseq_ac": "NP_012054", "gene_names_uniprotkb": "SSP1", "gene_names_refseq": "SPO3; SSP1", "protein_names_uniprotkb": "Sporulation-specific protein 1", "protein_names_refseq": "Ssp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR184W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11742972;24374639;8091229;9372934", "class_list": "", "function": "Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May be required for the formation of ADY3 and DON1-containing protein coats at the leading edge of the PSMs during meiosis II., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLD2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005628 prospore membrane;GO:0070056 prospore membrane leading edge", "go_biological_process": "GO:0051301 cell division;GO:0030476 ascospore wall assembly;GO:0032120 ascospore-type prospore membrane formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38871-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38985-1", "uniprot_id": "SRP14_YEAST", "mass": 16430.0, "length": 146, "protein_name": "Signal recognition particle subunit SRP14", "gene_name": "SRP14", "organism": "Yeast", "refseq_name": "RNA-binding signal recognition particle subunit SRP14", "refseq_ac": "NP_010191", "gene_names_uniprotkb": "SRP14; D2404", "gene_names_refseq": "SRP14", "protein_names_uniprotkb": "Signal recognition particle subunit SRP14; Signal recognition particle 14 kDa protein homolog", "protein_names_refseq": "RNA-binding signal recognition particle subunit SRP14", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL092W); (R-SCE-1799339); (R-SCE-6798695)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10573124;11352936;14562106;17322287;18407956;19795423;19823750;21126336;24374639;32597660;33481703;33491328;7925282;8923743;9169867", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:10573124, PubMed:7925282). The SRP complex is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences (PubMed:10573124). It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting (PubMed:10573124). SRP14 binds scR1 RNA to form the probable Alu domain of SRP responsible for elongation arrest (PubMed:10573124)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRQ6", "ec_number_list": "", "go_molecular_function": "GO:0030942 endoplasmic reticulum signal peptide binding;GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005634 nucleus", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39927-1", "uniprot_id": "PTI1_YEAST", "mass": 46983.0, "length": 425, "protein_name": "Protein PTI1", "gene_name": "PTI1", "organism": "Yeast", "refseq_name": "cleavage polyadenylation factor subunit PTI1", "refseq_ac": "NP_011672", "gene_names_uniprotkb": "PTI1; G6670", "gene_names_refseq": "PTI1", "protein_names_uniprotkb": "Protein PTI1", "protein_names_refseq": "cleavage polyadenylation factor subunit PTI1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR156W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12773397;12819204;14562106;15665377;17322287;17330950;18407956;19684113;19779198;19795423;19823750;20702584;21177495;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8585325;9169869", "class_list": "", "function": "Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation. PTI1 is required for 3'-end formation of snoRNAs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VUT6", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0031124 mRNA 3'-end processing;GO:0031126 sno(s)RNA 3'-end processing;GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled;GO:0030847 termination of RNA polymerase II transcription, exosome-dependent", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P39927-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40060-1", "uniprot_id": "IES5_YEAST", "mass": 14312.0, "length": 125, "protein_name": "Ino eighty subunit 5", "gene_name": "IES5", "organism": "Yeast", "refseq_name": "Ies5p", "refseq_ac": "NP_011017", "gene_names_uniprotkb": "IES5", "gene_names_refseq": "IES5", "protein_names_uniprotkb": "Ino eighty subunit 5", "protein_names_refseq": "Ies5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER092W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12887900;14562095;14562106;17563356;18407956;19779198;19795423;19823750;21126336;22814378;23749301;24374639;32597660;33481703;33491328;9169868", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLZ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031011 Ino80 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40060-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40079-1", "uniprot_id": "LCP5_YEAST", "mass": 40794.0, "length": 357, "protein_name": "U3 small nucleolar ribonucleoprotein protein LCP5", "gene_name": "LCP5", "organism": "Yeast", "refseq_name": "small subunit rRNA maturation protein LCP5", "refseq_ac": "NP_011053", "gene_names_uniprotkb": "LCP5; SYGP-ORF43", "gene_names_refseq": "LCP5", "protein_names_uniprotkb": "U3 small nucleolar ribonucleoprotein protein LCP5", "protein_names_refseq": "small subunit rRNA maturation protein LCP5", "tax_id": 559292, "disease": "", "pathway": " (sce:YER127W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;14690591;17563356;18407956;19779198;19795423;19823750;21126336;22218487;22814378;23749301;24374639;32597660;33481703;33491328;9169868;9814757", "class_list": "", "function": "Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 of the pre-ribosomal RNA. Participates in ribosome biogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM33", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030532 small nuclear ribonucleoprotein complex;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P40079-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40342-1", "uniprot_id": "SWM2_YEAST", "mass": 17097.0, "length": 146, "protein_name": "Nucleolar protein SWM2", "gene_name": "SWM2", "organism": "Yeast", "refseq_name": "Swm2p", "refseq_ac": "NP_014401", "gene_names_uniprotkb": "SWM2; N2033", "gene_names_refseq": "SWM2", "protein_names_uniprotkb": "Nucleolar protein SWM2; Synthetic With MUD2-delta protein 2", "protein_names_refseq": "Swm2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR004W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12489128;14562095;14562106;14654430;17322287;19466415;20360394;24374639;7900425;9169873", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1I0;Q540B3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40342-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40366-1", "uniprot_id": "DLS1_YEAST", "mass": 18793.0, "length": 167, "protein_name": "Protein DLS1", "gene_name": "DLS1", "organism": "Yeast", "refseq_name": "Dls1p", "refseq_ac": "NP_012470", "gene_names_uniprotkb": "DLS1; HRD167; J1115", "gene_names_refseq": "DLS1", "protein_names_uniprotkb": "Protein DLS1; DPB3-like subunit of ISW2 complex 1", "protein_names_refseq": "Dls1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL065C); (R-SCE-6782135); (R-SCE-68952); (R-SCE-68962)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "11081629;11238944;11489850;11533234;14562095;14562106;14673157;15024052;17322287;18407956;19795423;19823750;20702584;23749301;24374639;32597660;33481703;33491328;7762302;8641269", "class_list": "", "function": "Functions as a component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. DLS1 is partially required for the ISW2 complex chromatin remodeling activity and is not required for its interaction with chromatin., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWB7", "ec_number_list": "", "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0008623 CHRAC;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40366-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40468-1", "uniprot_id": "TAO3_YEAST", "mass": 269858.0, "length": 2376, "protein_name": "Cell morphogenesis protein PAG1", "gene_name": "TAO3", "organism": "Yeast", "refseq_name": "Tao3p", "refseq_ac": "NP_012137", "gene_names_uniprotkb": "TAO3; PAG1", "gene_names_refseq": "PAG1; TAO3", "protein_names_uniprotkb": "Cell morphogenesis protein PAG1; Protein TAO3", "protein_names_refseq": "Tao3p", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); Pan-Chung-Bellen syndrome (Disease Ontology:DOID:0061146)", "pathway": " (sce:YIL129C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11854408;14562106;16273108;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169870", "class_list": "", "function": "Seems to play a role in cell morphogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVF8;Q45T93", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005938 cell cortex;GO:0030427 site of polarized growth;GO:0000131 incipient cellular bud site;GO:0005933 cellular bud", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0007114 cell budding;GO:0007118 budding cell apical bud growth", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40468-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40483-1", "uniprot_id": "YIK8_YEAST", "mass": 77414.0, "length": 696, "protein_name": "Putative zinc metalloproteinase YIL108W", "gene_name": "", "organism": "Yeast", "refseq_name": "putative metalloendopeptidase", "refseq_ac": "NP_012158", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative zinc metalloproteinase YIL108W; 3.4.24.-", "protein_names_refseq": "putative metalloendopeptidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL108W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;17322287;18407956;21126336;22106047;22814378;24374639;32597660;33481703;33491328;9169870", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVH9;Q6B2N8", "ec_number_list": "", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P40483-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40560-1", "uniprot_id": "YIA1_YEAST", "mass": 59732.0, "length": 513, "protein_name": "Ankyrin repeat-containing protein YIL001W", "gene_name": "YIA1W", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_012265", "gene_names_uniprotkb": "YIA1W", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat-containing protein YIL001W", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL001W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;19795423;19823750;24374639;33491328;7762303;9169870", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVT0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40576-1", "uniprot_id": "INA22_YEAST", "mass": 24597.0, "length": 216, "protein_name": "Inner membrane assembly complex subunit 22", "gene_name": "INA22", "organism": "Yeast", "refseq_name": "Ina22p", "refseq_ac": "NP_012290", "gene_names_uniprotkb": "INA22", "gene_names_refseq": "INA22", "protein_names_uniprotkb": "Inner membrane assembly complex subunit 22; INA complex 22 kDa subunit", "protein_names_refseq": "Ina22p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR024C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;14576278;24374639;24942160;9169870", "class_list": "", "function": "Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVV5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1990524 INA complex", "go_biological_process": "GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40576-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41912-1", "uniprot_id": "ERFD_YEAST", "mass": 26542.0, "length": 237, "protein_name": "Ras modification protein ERF4", "gene_name": "SHR5", "organism": "Yeast", "refseq_name": "Shr5p", "refseq_ac": "NP_014531", "gene_names_uniprotkb": "SHR5; ERF4; HRC237", "gene_names_refseq": "ERF4; SHR5", "protein_names_uniprotkb": "Ras modification protein ERF4; Hyperactive Ras suppressor protein 5", "protein_names_refseq": "Shr5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL110W); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12193598;12379641;14562106;24374639;33491328;7502582;7532279;9169874", "class_list": "", "function": "The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins (PubMed:12193598, PubMed:12379641, PubMed:7532279). Palmitoylates RAS2, which is required for its proper plasma membrane localization (PubMed:12193598, PubMed:12379641, PubMed:7532279)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1V7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0031211 endoplasmic reticulum palmitoyltransferase complex", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P41912-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P42900-1", "uniprot_id": "SLS1_YEAST", "mass": 73257.0, "length": 643, "protein_name": "Sigma-like sequence protein 1, mitochondrial", "gene_name": "SLS1", "organism": "Yeast", "refseq_name": "Sls1p", "refseq_ac": "NP_013240", "gene_names_uniprotkb": "SLS1; L3162", "gene_names_refseq": "SLS1", "protein_names_uniprotkb": "Sigma-like sequence protein 1, mitochondrial; Protein SLS1", "protein_names_refseq": "Sls1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR139C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11805046;14562106;17322287;24374639;8917313;9169871", "class_list": "", "function": "Involved in aerobic respiration where it is required for assembly of respiratory chain enzyme complexes III and IV. Also has a role in mitochondrial gene expression. May be part of a mitochondrial membrane-associated RNA-shuttling system, delivering NAM1-associated transcripts to the translation machinery., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYD4;Q6B228", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0070124 mitochondrial translational initiation;GO:0009060 aerobic respiration;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P42900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43124-1", "uniprot_id": "NSE4_YEAST", "mass": 46121.0, "length": 402, "protein_name": "Non-structural maintenance of chromosome element 4", "gene_name": "NSE4", "organism": "Yeast", "refseq_name": "Smc5-Smc6 complex subunit NSE4", "refseq_ac": "NP_010178", "gene_names_uniprotkb": "NSE4; D2354; QRI2", "gene_names_refseq": "NSE4; QRI2", "protein_names_uniprotkb": "Non-structural maintenance of chromosome element 4; Non-SMC element 4; Protein QRI2", "protein_names_refseq": "Smc5-Smc6 complex subunit NSE4", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL105W); (R-SCE-3108214)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "14562095;14690591;15738391;15752197;17287358;17563356;18407956;19779198;20702584;23749301;24374639;32597660;33481703;33491328;33502312;7725801;8896274;9169867", "class_list": "", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRP5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0140588 chromatin looping", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P43124-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P43579-1", "uniprot_id": "IES1_YEAST", "mass": 78753.0, "length": 692, "protein_name": "Ino eighty subunit 1", "gene_name": "IES1", "organism": "Yeast", "refseq_name": "Ies1p", "refseq_ac": "NP_116641", "gene_names_uniprotkb": "IES1", "gene_names_refseq": "IES1", "protein_names_uniprotkb": "Ino eighty subunit 1", "protein_names_refseq": "Ies1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YFL013C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "12887900;14562095;14562106;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20190278;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33481703;33491328;7670463", "class_list": "", "function": "Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTL6;E9P952", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031011 Ino80 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P43579-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46671-1", "uniprot_id": "FAR3_YEAST", "mass": 24032.0, "length": 204, "protein_name": "Factor arrest protein 3", "gene_name": "FAR3", "organism": "Yeast", "refseq_name": "Far3p", "refseq_ac": "NP_013767", "gene_names_uniprotkb": "FAR3; YM9796.05", "gene_names_refseq": "FAR3", "protein_names_uniprotkb": "Factor arrest protein 3", "protein_names_refseq": "Far3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR052W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12588993;14562095;14562106;23749301;24374639;33491328;7483842;9169872", "class_list": "", "function": "Participates in the control of the reentry into the cell cycle following pheromone treatment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZM7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0071444 cellular response to pheromone;GO:0000321 re-entry into mitotic cell cycle after pheromone arrest;GO:1903939 regulation of TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46671-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47019-1", "uniprot_id": "ALB1_YEAST", "mass": 19287.0, "length": 175, "protein_name": "Ribosome biogenesis protein ALB1", "gene_name": "ALB1", "organism": "Yeast", "refseq_name": "Alb1p", "refseq_ac": "NP_012413", "gene_names_uniprotkb": "ALB1; J0723", "gene_names_refseq": "ALB1", "protein_names_uniprotkb": "Ribosome biogenesis protein ALB1", "protein_names_refseq": "Alb1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL122W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562095;14562106;16544271;16651379;16702403;17242366;17652132;19779198;23749301;24374639;30377154;32597660;33481703;33491328;8641269;8948101", "class_list": "", "function": "With ARX1, involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW64", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P47019-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47118-1", "uniprot_id": "YAE1_YEAST", "mass": 16076.0, "length": 141, "protein_name": "Protein YAE1", "gene_name": "YAE1", "organism": "Yeast", "refseq_name": "Yae1p", "refseq_ac": "NP_012601", "gene_names_uniprotkb": "YAE1; J1805", "gene_names_refseq": "YAE1", "protein_names_uniprotkb": "Protein YAE1", "protein_names_refseq": "Yae1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR067C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;14690591;17322287;23318452;24374639;26182403;33491328;8641269;8840504", "class_list": "", "function": "The complex LTO1:YAE1 functions as a target specific adapter that recruits apo-RLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWN8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0062092 Yae1-Lto1 complex", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47118-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47123-1", "uniprot_id": "MOG1_YEAST", "mass": 24307.0, "length": 218, "protein_name": "Nuclear import protein MOG1", "gene_name": "MOG1", "organism": "Yeast", "refseq_name": "Ran GTPase-binding protein MOG1", "refseq_ac": "NP_012608", "gene_names_uniprotkb": "MOG1; J1827", "gene_names_refseq": "MOG1", "protein_names_uniprotkb": "Nuclear import protein MOG1; Multicopy suppressor of GSP1", "protein_names_refseq": "Ran GTPase-binding protein MOG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR074W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10860733;11509570;14562106;24374639;8641269;8840504;9860978", "class_list": "", "function": "Involved in the Ran-GTPase system for nuclear protein import and poly(A)+ mRNA export., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWP4", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0051028 mRNA transport;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47130-1", "uniprot_id": "CSN12_YEAST", "mass": 49482.0, "length": 423, "protein_name": "Cop9 signalosome complex subunit 12", "gene_name": "CSN12", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_012617", "gene_names_uniprotkb": "CSN12; J1860", "gene_names_refseq": "CSN12", "protein_names_uniprotkb": "Cop9 signalosome complex subunit 12", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR084W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12446563;12672462;14562095;14562106;19061648;19289793;21149575;24374639;33491328;8641269;8840504", "class_list": "", "function": "Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response. CSN12 forms a complex with THP3 that is recruited to transcribed genes and required for transcription elongation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWQ3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000791 euchromatin;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000398 mRNA splicing, via spliceosome;GO:0071444 cellular response to pheromone;GO:2000434 regulation of protein neddylation;GO:0000747 conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P47130-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47133-1", "uniprot_id": "EMC2_YEAST", "mass": 33855.0, "length": 292, "protein_name": "ER membrane protein complex subunit 2", "gene_name": "EMC2", "organism": "Yeast", "refseq_name": "Emc2p", "refseq_ac": "NP_012621", "gene_names_uniprotkb": "EMC2; J1875", "gene_names_refseq": "EMC2", "protein_names_uniprotkb": "ER membrane protein complex subunit 2", "protein_names_refseq": "Emc2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR088C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;17322287;19325107;22814378;24374639;29809151;8641269;8840504", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWQ6;Q66R61", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0072546 EMC complex;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0015914 phospholipid transport;GO:0006644 phospholipid metabolic process;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0034975 protein folding in endoplasmic reticulum;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P47133-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P47167-1", "uniprot_id": "CENPK_YEAST", "mass": 27568.0, "length": 239, "protein_name": "Inner kinetochore subunit MCM22", "gene_name": "MCM22", "organism": "Yeast", "refseq_name": "Mcm22p", "refseq_ac": "NP_012669", "gene_names_uniprotkb": "MCM22; J2122", "gene_names_refseq": "MCM22", "protein_names_uniprotkb": "Inner kinetochore subunit MCM22; CENP-K homolog; Constitutive centromere-associated network protein MCM22; Minichromosome maintenance protein 22", "protein_names_refseq": "Mcm22p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR135C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11782448;12408861;14562095;14562106;14690591;22561346;24374639;33229814;8641269;9987135", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VWV3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P47167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P48232-1", "uniprot_id": "SNAPN_YEAST", "mass": 11461.0, "length": 102, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit SNN1", "gene_name": "SNN1", "organism": "Yeast", "refseq_name": "Snn1p", "refseq_ac": "NP_014313", "gene_names_uniprotkb": "SNN1; N2254", "gene_names_refseq": "SNN1", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit SNN1; BLOC-1 subunit SNN1; SNAPIN-like protein 1", "protein_names_refseq": "Snn1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL086W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;17322287;21159114;24374639;33491328;8740422;9169873", "class_list": "", "function": "Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W193", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P48232-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P50946-1", "uniprot_id": "OCA1_YEAST", "mass": 27205.0, "length": 238, "protein_name": "Putative tyrosine-protein phosphatase OCA1", "gene_name": "OCA1", "organism": "Yeast", "refseq_name": "putative tyrosine protein phosphatase OCA1", "refseq_ac": "NP_014300", "gene_names_uniprotkb": "OCA1; N2194", "gene_names_refseq": "OCA1", "protein_names_uniprotkb": "Putative tyrosine-protein phosphatase OCA1; 3.1.3.48; Oxidant-induced cell-cycle arrest protein 1", "protein_names_refseq": "putative tyrosine protein phosphatase OCA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL099C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11408586;12912987;14562095;14562106;16273108;16429126;18205808;19779198;19823750;20489023;22814378;24374639;24909858;32597660;33481703;33491328;8701612;9169873;9757831", "class_list": "", "function": "Putative tyrosine-protein phosphatase required for protection against superoxide stress. Involved in cell-cycle delay in response to linoleic acid hydroperoxide (LoaOOH)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W180;Q45U02", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.2", "go_molecular_function": "GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P50946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P51533-1", "uniprot_id": "PDR10_YEAST", "mass": 176461.0, "length": 1564, "protein_name": "ATP-dependent permease PDR10", "gene_name": "PDR10", "organism": "Yeast", "refseq_name": "ATP-binding cassette multidrug transporter PDR10", "refseq_ac": "NP_014973", "gene_names_uniprotkb": "PDR10", "gene_names_refseq": "PDR10", "protein_names_uniprotkb": "ATP-dependent permease PDR10", "protein_names_refseq": "ATP-binding cassette multidrug transporter PDR10", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR328W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24374639;33481703;8896263;9169874", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W325", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:1990414 replication-born double-strand break repair via sister chromatid exchange;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52868-1", "uniprot_id": "CWC23_YEAST", "mass": 33237.0, "length": 283, "protein_name": "Pre-mRNA-splicing factor CWC23", "gene_name": "CWC23", "organism": "Yeast", "refseq_name": "U2-type spliceosomal complex subunit CWC23", "refseq_ac": "NP_011387", "gene_names_uniprotkb": "CWC23; G2861", "gene_names_refseq": "CWC23", "protein_names_uniprotkb": "Pre-mRNA-splicing factor CWC23; Complexed with CEF1 protein 23", "protein_names_refseq": "U2-type spliceosomal complex subunit CWC23", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL128C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10029993;11884590;12748633;12847107;14562095;14690591;15170475;17322287;22814378;24374639;33491328;8686378;9169869", "class_list": "", "function": "Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU20;Q6B1S2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000390 spliceosomal complex disassembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P52868-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53121-1", "uniprot_id": "FLC3_YEAST", "mass": 90761.0, "length": 802, "protein_name": "Putative flavin carrier protein 3", "gene_name": "FLC3", "organism": "Yeast", "refseq_name": "putative flavin adenine dinucleotide transporter", "refseq_ac": "NP_011376", "gene_names_uniprotkb": "FLC3; G2812", "gene_names_refseq": "FLC3", "protein_names_uniprotkb": "Putative flavin carrier protein 3; FAD transporter 3; TRP-like ion channel FLC3", "protein_names_refseq": "putative flavin adenine dinucleotide transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL139W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "16717099;16847258;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;8840506;9046099;9169869", "class_list": "", "function": "May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VU10", "ec_number_list": "", "go_molecular_function": "GO:0015230 FAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0030148 sphingolipid biosynthetic process;GO:0015883 FAD transport;GO:0009272 fungal-type cell wall biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P53121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53125-1", "uniprot_id": "ITC1_YEAST", "mass": 145643.0, "length": 1264, "protein_name": "Imitation switch two complex protein 1", "gene_name": "ITC1", "organism": "Yeast", "refseq_name": "Itc1p", "refseq_ac": "NP_011382", "gene_names_uniprotkb": "ITC1; G2842", "gene_names_refseq": "ITC1", "protein_names_uniprotkb": "Imitation switch two complex protein 1", "protein_names_refseq": "Itc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL133W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11081629;11238944;11489850;11533234;12624196;14562106;14673157;15024052;17287358;17563356;18407956;19795423;19823750;21126336;23749301;24374639;32597660;33229814;33481703;33491328;8840506;9169869", "class_list": "", "function": "Functions as a component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex. ITC1 is required for nucleosome-stimulated ATPase activity and chromatin-remodeling activity of the complex. Required for the repression of MATa a-specific genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VU16", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0008623 CHRAC;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P53125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53136-1", "uniprot_id": "NSA1_YEAST", "mass": 51907.0, "length": 463, "protein_name": "Ribosome biogenesis protein NSA1", "gene_name": "NSA1", "organism": "Yeast", "refseq_name": "ribosome biosynthesis protein NSA1", "refseq_ac": "NP_011404", "gene_names_uniprotkb": "NSA1; G2990", "gene_names_refseq": "NSA1", "protein_names_uniprotkb": "Ribosome biogenesis protein NSA1; NOP7-associated protein 1", "protein_names_refseq": "ribosome biosynthesis protein NSA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL111W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11583614;14562095;14562106;15100437;15769876;16544271;17443350;24374639;28416111;33481703;33491328;9046090;9169869", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU36", "ec_number_list": "", "go_molecular_function": "GO:1990275 preribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53136-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53150-1", "uniprot_id": "XRCC4_YEAST", "mass": 48259.0, "length": 421, "protein_name": "Non-homologous end-joining factor LIF1", "gene_name": "LIF1", "organism": "Yeast", "refseq_name": "Lif1p", "refseq_ac": "NP_011425", "gene_names_uniprotkb": "LIF1", "gene_names_refseq": "LIF1", "protein_names_uniprotkb": "Non-homologous end-joining factor LIF1; Ligase-interacting factor 1", "protein_names_refseq": "Lif1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL090W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11711435;12235149;14562095;14562106;16388993;17322287;17563356;17567543;19779198;20489023;22563681;23749301;24374639;29778533;32597660;33481703;33491328;9169869;9290212;9670033", "class_list": "", "function": "Involved in non-homologous repair of DNA double-strand breaks (PubMed:9670033). Stabilizes DNL4 (PubMed:9670033)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU55;E9P953", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0032807 DNA ligase IV complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P53150-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53295-1", "uniprot_id": "RBG2_YEAST", "mass": 41006.0, "length": 368, "protein_name": "Ribosome-interacting GTPase 2", "gene_name": "RBG2", "organism": "Yeast", "refseq_name": "Rbg2p", "refseq_ac": "NP_011689", "gene_names_uniprotkb": "RBG2; GIR1", "gene_names_refseq": "GIR1; RBG2", "protein_names_uniprotkb": "Ribosome-interacting GTPase 2; GTP-binding protein RBG2", "protein_names_refseq": "Rbg2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR173W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;18407956;19448108;19779198;22814378;23749301;24374639;33481703;33491328;9169869", "class_list": "", "function": "Involved in ribosomal function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUV7", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:1903833 positive regulation of cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53295-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53720-1", "uniprot_id": "DUS2_YEAST", "mass": 42816.0, "length": 384, "protein_name": "tRNA-dihydrouridine(20) synthase [NAD(P)+]", "gene_name": "SMM1", "organism": "Yeast", "refseq_name": "tRNA-dihydrouridine(20) synthase (NAD(+))", "refseq_ac": "NP_014412", "gene_names_uniprotkb": "SMM1; DUS2; N2065", "gene_names_refseq": "DUS2; SMM1", "protein_names_uniprotkb": "tRNA-dihydrouridine(20) synthase [NAD(P)+]; 1.3.1.-; 1.3.1.91; mRNA-dihydrouridine synthase DUS2; tRNA-dihydrouridine synthase 2", "protein_names_refseq": "tRNA-dihydrouridine(20) synthase (NAD(+))", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR015W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12003496;14562095;14562106;14970222;19756047;19795423;19823750;24374639;33491328;9169873", "class_list": "", "function": "Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:12003496, PubMed:14970222). Specifically modifies U20 in cytoplasmic tRNAs (PubMed:12003496, PubMed:14970222). Also able to mediate dihydrouridylation of some mRNAs, thereby affecting their translation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1J0", "ec_number_list": "1.3.1.-;1.3.1.91;1.3.1.88;1.3.1.89;1.3.1.90", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0106414 mRNA dihydrouridine synthase activity;GO:0102264 tRNA-dihydrouridine20 synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0008033 tRNA processing;GO:0006400 tRNA modification;GO:0002943 tRNA dihydrouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P53720-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53721-1", "uniprot_id": "RCF2_YEAST", "mass": 25344.0, "length": 224, "protein_name": "Respiratory supercomplex factor 2, mitochondrial", "gene_name": "RCF2", "organism": "Yeast", "refseq_name": "Rcf2p", "refseq_ac": "NP_014415", "gene_names_uniprotkb": "RCF2; AIM38; N3185", "gene_names_refseq": "AIM38; RCF2", "protein_names_uniprotkb": "Respiratory supercomplex factor 2, mitochondrial; Altered inheritance of mitochondria protein 38", "protein_names_refseq": "Rcf2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR018W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;14576278;19300474;19750512;22310663;22342701;22814378;24374639;29240987;30598554;30683696;31591265;33491328;9169873", "class_list": "", "function": "Assembly factor that plays a role in the assembly of the respiratory chain supercomplexes (SCs) composed of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV). May be required for late-stage assembly of the COX12 and COX13 subunits (PubMed:22310663, PubMed:22342701). Required for the generation and maintenance of a normal proton motive force (PMF) across the inner mitochondrial membrane (IMM) by preventing proton leakage through an inactive population of CIV that accumulates when RCF1 and/or RCF2 proteins are absent (PubMed:30683696, PubMed:31591265)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1J3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0031334 positive regulation of protein-containing complex assembly;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53721-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53725-1", "uniprot_id": "MPP6_YEAST", "mass": 21142.0, "length": 186, "protein_name": "M-phase phosphoprotein 6 homolog", "gene_name": "MPP6", "organism": "Yeast", "refseq_name": "Mpp6p", "refseq_ac": "NP_014421", "gene_names_uniprotkb": "MPP6; N3230", "gene_names_refseq": "MPP6", "protein_names_uniprotkb": "M-phase phosphoprotein 6 homolog; Exosome-associated RNA-binding protein MPP6", "protein_names_refseq": "Mpp6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR024W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14562095;14562106;16702403;17330950;17563356;18407956;18591258;19046973;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;24909858;32597660;33481703;33491328;9169873", "class_list": "", "function": "RNA-binding protein that associates with the RNA exosome complex (By similarity). Involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA) derived from intergenic regions and the ribosomal DNA spacer heterochromatin (PubMed:18591258)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1J9", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process;GO:0071039 nuclear polyadenylation-dependent CUT catabolic process;GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing;GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P53725-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53735-1", "uniprot_id": "ZRG17_YEAST", "mass": 67461.0, "length": 605, "protein_name": "Protein ZRG17", "gene_name": "ZRG17", "organism": "Yeast", "refseq_name": "Zn(2+) transporter ZRG17", "refseq_ac": "NP_014437", "gene_names_uniprotkb": "ZRG17; N3403", "gene_names_refseq": "ZRG17", "protein_names_uniprotkb": "Protein ZRG17; Zinc-regulated gene 17 protein", "protein_names_refseq": "Zn(2+) transporter ZRG17", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR039C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562095;16847258;17287358;17322287;17330950;18407956;19684113;19779198;21126336;21177495;22218487;23749301;24374639;24909858;32597660;33229814;33481703;33491328;9169873", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W1L5;E9P919", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006829 zinc ion transport", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P53735-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53740-1", "uniprot_id": "YN8S_YEAST", "mass": 44542.0, "length": 393, "protein_name": "Phospholipid-transporting ATPase accessory subunit CRF1", "gene_name": "N3453", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "N3453", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipid-transporting ATPase accessory subunit CRF1; CDC50/ROS3 family protein 1; CRF1", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR048W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;15090616;16847258;17093059;19411703;22791719;24374639;9169873", "class_list": "", "function": "Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine and small amounts of phosphatidylethanolamine from the lumen to the cytosolic leaflet of the trans-Golgi network and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:22791719). May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6W1M3", "ec_number_list": "", "go_molecular_function": "GO:0015247 aminophospholipid flippase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53740-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53742-1", "uniprot_id": "NOG2_YEAST", "mass": 55489.0, "length": 486, "protein_name": "Nucleolar GTP-binding protein 2", "gene_name": "NOG2", "organism": "Yeast", "refseq_name": "putative GTPase NOG2", "refseq_ac": "NP_014451", "gene_names_uniprotkb": "NOG2; N3484", "gene_names_refseq": "NOG2; NUG2", "protein_names_uniprotkb": "Nucleolar GTP-binding protein 2", "protein_names_refseq": "putative GTPase NOG2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR053C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11707418;14562106;18407956;19779198;20702584;21126336;21177495;23749301;24374639;32597660;33481703;33491328;9169873", "class_list": "", "function": "GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1M8", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:2000200 regulation of ribosomal subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53742-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53746-1", "uniprot_id": "FRE4_YEAST", "mass": 82015.0, "length": 719, "protein_name": "Ferric reductase transmembrane component 4", "gene_name": "FRE4", "organism": "Yeast", "refseq_name": "ferric-chelate reductase", "refseq_ac": "NP_014458", "gene_names_uniprotkb": "FRE4; N3518", "gene_names_refseq": "FRE4", "protein_names_uniprotkb": "Ferric reductase transmembrane component 4; 1.16.1.9; Ferric-chelate reductase 4", "protein_names_refseq": "ferric-chelate reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR060W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10341420;11120744;17563356;24374639;32597660;33481703;9169873;9726978", "class_list": "", "function": "Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to dihydroxamate rhodotorulic acid. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W1N5", "ec_number_list": "1.16.1.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0052851 ferric-chelate reductase (NADPH) activity;GO:0000293 ferric-chelate reductase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0015677 copper ion import;GO:0006826 iron ion transport;GO:0015891 siderophore transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53746-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53753-1", "uniprot_id": "ENG1_YEAST", "mass": 121064.0, "length": 1117, "protein_name": "Glucan endo-1,3-beta-D-glucosidase 1", "gene_name": "DSE4", "organism": "Yeast", "refseq_name": "endo-1,3(4)-beta-glucanase", "refseq_ac": "NP_014465", "gene_names_uniprotkb": "DSE4; ENG1; N3547", "gene_names_refseq": "DSE4; ENG1", "protein_names_uniprotkb": "Glucan endo-1,3-beta-D-glucosidase 1; 3.2.1.39; Daughter specific expression protein 4; Endo-1,3-beta-glucanase 1; Laminarinase-1", "protein_names_refseq": "endo-1,3(4)-beta-glucanase", "tax_id": 559292, "disease": "", "pathway": " (sce:YNR067C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12455695;14562106;24374639;9169873", "class_list": "", "function": "Cleaves internal linkages in 1,3-beta-glucan (PubMed:12455695). Involved in the dissolution of the mother-daughter septum during cell separation (PubMed:12455695)., [UniProtKB, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6W1P2", "ec_number_list": "", "go_molecular_function": "GO:0042973 glucan endo-1,3-beta-D-glucosidase activity;GO:0052861 endo-1,3(4)-beta-glucanase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0030428 cell septum;GO:0005621 cellular bud scar;GO:0005935 cellular bud neck;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0000272 polysaccharide catabolic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P53753-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53769-1", "uniprot_id": "CWC24_YEAST", "mass": 29741.0, "length": 259, "protein_name": "Pre-mRNA-splicing factor CWC24", "gene_name": "CWC24", "organism": "Yeast", "refseq_name": "U2-type spliceosomal complex subunit CWC24", "refseq_ac": "NP_013427", "gene_names_uniprotkb": "CWC24; L8543.3", "gene_names_refseq": "CWC24", "protein_names_uniprotkb": "Pre-mRNA-splicing factor CWC24; Complexed with CEF1 protein 24", "protein_names_refseq": "U2-type spliceosomal complex subunit CWC24", "tax_id": 559292, "disease": "nonphotosensitive trichothiodystrophy 5 (Disease Ontology:DOID:0111868)", "pathway": " (sce:YLR323C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11884590;14562095;14562106;15665377;17287358;17330950;18407956;19779198;19795423;19823750;20702584;21177495;23749301;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Involved in pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYW5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0034247 snoRNA splicing;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P53769-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53832-1", "uniprot_id": "WSC2_YEAST", "mass": 52292.0, "length": 503, "protein_name": "Cell wall integrity and stress response component 2", "gene_name": "WSC2", "organism": "Yeast", "refseq_name": "Wsc2p", "refseq_ac": "NP_014116", "gene_names_uniprotkb": "WSC2; N0583", "gene_names_refseq": "STA3; WSC2", "protein_names_uniprotkb": "Cell wall integrity and stress response component 2", "protein_names_refseq": "Wsc2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL283C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "15665377;17330950;18407956;19756047;19779198;20702584;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169873", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0R1", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030427 site of polarized growth;GO:0000324 fungal-type vacuole;GO:0005933 cellular bud", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0009408 response to heat;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53832-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53838-1", "uniprot_id": "BOR1_YEAST", "mass": 65028.0, "length": 576, "protein_name": "Boron transporter 1", "gene_name": "BOR1", "organism": "Yeast", "refseq_name": "Bor1p", "refseq_ac": "NP_014124", "gene_names_uniprotkb": "BOR1; N0626", "gene_names_refseq": "BOR1", "protein_names_uniprotkb": "Boron transporter 1", "protein_names_refseq": "Bor1p", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); metabolic acidosis (Disease Ontology:DOID:0050758); short QT syndrome (Disease Ontology:DOID:0050793); congenital hereditary endothelial dystrophy of cornea (Disease Ontology:DOID:0060649); proximal renal tubular acidosis-ocular anomaly syndrome (Disease Ontology:DOID:0061195); Usher syndrome type 2C (Disease Ontology:DOID:0110839); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hereditary spherocytosis type 4 (Disease Ontology:DOID:0110919); corneal dystrophy-perceptive deafness syndrome (Disease Ontology:DOID:0111620); hypertension (Disease Ontology:DOID:10763); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); prediabetes syndrome (Disease Ontology:DOID:11716); iron deficiency anemia (Disease Ontology:DOID:11758); malaria (Disease Ontology:DOID:12365); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); hereditary spherocytosis (Disease Ontology:DOID:12971); osteopetrosis (Disease Ontology:DOID:13533); renal tubular acidosis (Disease Ontology:DOID:14219); anemia (Disease Ontology:DOID:2355); hereditary elliptocytosis (Disease Ontology:DOID:2373); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); cholangiocarcinoma (Disease Ontology:DOID:4947); congenital hemolytic anemia (Disease Ontology:DOID:589)", "pathway": " (sce:YNL275W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11401825;14562106;16565073;16847258;16923078;17166224;17459946;21126336;23749301;24374639;33481703;33491328;9169873", "class_list": "", "function": "Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0R9", "ec_number_list": "", "go_molecular_function": "GO:0005452 solute:inorganic anion antiporter activity;GO:0080139 borate efflux transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0005774 vacuolar membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006820 monoatomic anion transport;GO:0050801 monoatomic ion homeostasis;GO:0046713 borate transport;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P53838-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53839-1", "uniprot_id": "GOR1_YEAST", "mass": 38831.0, "length": 350, "protein_name": "Glyoxylate reductase 1", "gene_name": "GOR1", "organism": "Yeast", "refseq_name": "glyoxylate reductase", "refseq_ac": "NP_014125", "gene_names_uniprotkb": "GOR1; N0631", "gene_names_refseq": "GOR1", "protein_names_uniprotkb": "Glyoxylate reductase 1; 1.1.1.26; 1.1.1.79; 1.1.1.81", "protein_names_refseq": "glyoxylate reductase", "tax_id": 559292, "disease": "primary hyperoxaluria type 2 (Disease Ontology:DOID:0111671); primary hyperoxaluria (Disease Ontology:DOID:2977)", "pathway": " (sce:YNL274C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;14576278;17173333;17322287;18407956;21126336;23749301;24374639;33481703;33491328;9169873", "class_list": "", "function": "Glyoxylate reductase that reversibly reduces glyoxylate to glycolate, or alternatively hydroxypyruvate to D-glycerate, using either NADPH or NADH as a cosubstrate (PubMed:17173333). Does not act as a hydroxyisocaproate dehydrogenase even though it also has minor activity on alpha-ketoisocaproate (PubMed:17173333)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0S0", "ec_number_list": "1.1.1.79;1.1.1.81;1.1.1.26", "go_molecular_function": "GO:0008465 hydroxypyruvate reductase (NADH) activity;GO:0016618 hydroxypyruvate reductase [NAD(P)H] activity;GO:0030267 glyoxylate reductase (NADPH) activity;GO:0051287 NAD binding;GO:0047964 glyoxylate reductase (NADH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009436 glyoxylate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53839-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53843-1", "uniprot_id": "IST1_YEAST", "mass": 34496.0, "length": 298, "protein_name": "Vacuolar protein sorting-associated protein IST1", "gene_name": "IST1", "organism": "Yeast", "refseq_name": "Ist1p", "refseq_ac": "NP_014134", "gene_names_uniprotkb": "IST1; N0809", "gene_names_refseq": "IST1", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein IST1; Increased sodium tolerance protein 1", "protein_names_refseq": "Ist1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL265C); (R-SCE-6798695); (R-SCE-9668328)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "14562106;15665377;17563356;18032582;18032584;19684113;19795423;19823750;21177495;23749301;24374639;32597660;33481703;33491328;8740425;9169873", "class_list": "", "function": "Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole. Regulates the recruitment of VPS4 to the ESCRT-III complex, probably in conjunction with DID2, and VPS4 catalyzes the disassembly of the ESCRT-III complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0S8", "ec_number_list": "", "go_molecular_function": "GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0099638 endosome to plasma membrane protein transport;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P53843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53846-1", "uniprot_id": "LTO1_YEAST", "mass": 18896.0, "length": 162, "protein_name": "Protein LTO1", "gene_name": "LTO1", "organism": "Yeast", "refseq_name": "ribosome biosynthesis protein LTO1", "refseq_ac": "NP_014139", "gene_names_uniprotkb": "LTO1; N0838", "gene_names_refseq": "LTO1", "protein_names_uniprotkb": "Protein LTO1; LTO1 family protein YNL260C", "protein_names_refseq": "ribosome biosynthesis protein LTO1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL260C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;14690591;23318452;23749301;24374639;26182403;9169873;9234673", "class_list": "", "function": "Essential for life in oxygen, but nonessential under anaerobic conditions. Required for biogenesis of the large ribosomal subunit and initiation of translation in oxygen (PubMed:23318452). The complex LTO1:YAE1 functions as a target specific adapter that recruits apo-RLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0T3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0062092 Yae1-Lto1 complex", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53846-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53848-1", "uniprot_id": "FOL1_YEAST", "mass": 93120.0, "length": 824, "protein_name": "Folic acid synthesis protein FOL1", "gene_name": "FOL1", "organism": "Yeast", "refseq_name": "trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1", "refseq_ac": "NP_014143", "gene_names_uniprotkb": "FOL1; N0848", "gene_names_refseq": "FOL1", "protein_names_uniprotkb": "Folic acid synthesis protein FOL1; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; 7,8-dihydroneopterin aldolase; Dihydropteroate pyrophosphorylase; FASA; FASB; FASC; FASD; PPPK", "protein_names_refseq": "trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL256W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12748633;14562106;14576278;15169867;15826662;15905473;18086883;18407956;19684113;19779198;21177495;22814378;23749301;24374639;33229814;33481703;33491328;9169873;9234673", "class_list": "", "function": "Catalyzes three sequential steps of tetrahydrofolate biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W0T7;Q2VQX0", "ec_number_list": "2.5.1.15;2.7.6.3;4.1.2.25", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity;GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity;GO:0004150 dihydroneopterin aldolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0046656 folic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P53848-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53853-1", "uniprot_id": "VPS75_YEAST", "mass": 30615.0, "length": 264, "protein_name": "Vacuolar protein sorting-associated protein 75", "gene_name": "VPS75", "organism": "Yeast", "refseq_name": "Vps75p", "refseq_ac": "NP_014153", "gene_names_uniprotkb": "VPS75; N0890", "gene_names_refseq": "VPS75", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 75", "protein_names_refseq": "Vps75p", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 58 (Disease Ontology:DOID:0061032); prostate cancer (Disease Ontology:DOID:10283); gonadal dysgenesis (Disease Ontology:DOID:14447); seminoma (Disease Ontology:DOID:4440); hepatocellular carcinoma (Disease Ontology:DOID:684); sudden infant death syndrome (Disease Ontology:DOID:9007)", "pathway": " (sce:YNL246W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "12134085;14562095;14562106;17272723;17320445;17563356;18407956;18719104;19172748;19779198;19795423;19823750;20560668;20702584;21256037;21454705;22218487;23749301;24374639;27036862;29300933;31387991;32597660;33481703;33491328;9169873;9234673", "class_list": "", "function": "Histone chaperone which acts as a cofactor stimulating histone H3 acetylation by RTT109 (PubMed:17320445, PubMed:19172748, PubMed:21256037, PubMed:29300933, PubMed:31387991). Preferentially stimulates histone H3 'Lys-9' acetylation by RTT109 (PubMed:21256037, PubMed:29300933, PubMed:31387991). May also stimulate histone H3 'Lys-56' acetylation by RTT109 (PubMed:17320445). Assembles nucleosomes (in vitro) (PubMed:19172748)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0U7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0042393 histone binding;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0070775 H3 histone acetyltransferase complex", "go_biological_process": "GO:0015031 protein transport;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P53853-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53860-1", "uniprot_id": "PDR16_YEAST", "mass": 40714.0, "length": 351, "protein_name": "Phosphatidylinositol transfer protein PDR16", "gene_name": "PDR16", "organism": "Yeast", "refseq_name": "phosphatidylinositol transporter", "refseq_ac": "NP_014168", "gene_names_uniprotkb": "PDR16; N1158; SFH3", "gene_names_refseq": "PDR16; SFH3", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein PDR16; PITP; Pleiotropic drug resistance protein 16; SEC14 homolog 3", "protein_names_refseq": "phosphatidylinositol transporter", "tax_id": 559292, "disease": "Bothnia retinal dystrophy (Disease Ontology:DOID:0050683); Newfoundland cone-rod dystrophy (Disease Ontology:DOID:0111015); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); night blindness (Disease Ontology:DOID:8499)", "pathway": " (sce:YNL231C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10848624;12869188;14562095;14562106;17322287;17330950;18407956;19684113;19779198;19795423;19823750;20702584;21126336;23519406;23603387;23749301;24374639;24403601;27821475;32597660;33481703;33491328;8896273;9169873;9890948", "class_list": "", "function": "Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover. Regulates the release of fatty acids from lipid droplets (PubMed:24403601)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0W1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0032934 sterol binding;GO:0008526 phosphatidylinositol transfer activity", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0015914 phospholipid transport;GO:0009410 response to xenobiotic stimulus;GO:0008654 phospholipid biosynthetic process;GO:0043942 negative regulation of sexual sporulation resulting in formation of a cellular spore", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P53860-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53861-1", "uniprot_id": "ELOA1_YEAST", "mass": 43981.0, "length": 379, "protein_name": "Elongin-A", "gene_name": "ELA1", "organism": "Yeast", "refseq_name": "elongin A", "refseq_ac": "NP_014169", "gene_names_uniprotkb": "ELA1; N1161", "gene_names_refseq": "ELA1", "protein_names_uniprotkb": "Elongin-A", "protein_names_refseq": "elongin A", "tax_id": 559292, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (sce:YNL230C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10430890;10753924;14562106;17287358;17296727;19779198;23993092;24374639;32597660;33229814;33481703;33491328;8896273;9169873", "class_list": "", "function": "As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W0W2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070449 elongin complex;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53861-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53868-1", "uniprot_id": "ALG9_YEAST", "mass": 63777.0, "length": 555, "protein_name": "Alpha-1,2-mannosyltransferase ALG9", "gene_name": "ALG9", "organism": "Yeast", "refseq_name": "dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase", "refseq_ac": "NP_014180", "gene_names_uniprotkb": "ALG9; N1295", "gene_names_refseq": "ALG9", "protein_names_uniprotkb": "Alpha-1,2-mannosyltransferase ALG9; 2.4.1.259; 2.4.1.261; Asparagine-linked glycosylation protein 9; Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase", "protein_names_refseq": "dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase", "tax_id": 559292, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Il (Disease Ontology:DOID:0080564); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (sce:YNL219C); (R-SCE-446193)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15987956;16847258;24374639;8692962;9169873", "class_list": "", "function": "Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, catalyzes the addition of the seventh and ninth alpha-1,2-linked mannose residues to Man(6)GlcNAc(2)-PP-dolichol and Man(8)GlcNAc(2)-PP-dolichol respectively., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0X1", "ec_number_list": "2.4.1.259;2.4.1.261", "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0000030 mannosyltransferase activity;GO:0052918 dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity;GO:0052926 dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P53868-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53872-1", "uniprot_id": "PGA14_YEAST", "mass": 21966.0, "length": 204, "protein_name": "Hydrophilin YNL190W", "gene_name": "N1415", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_014209", "gene_names_uniprotkb": "N1415", "gene_names_refseq": "", "protein_names_uniprotkb": "Hydrophilin YNL190W", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL190W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10383953;10681550;14562106;22442684;24374639;9169873;9613572", "class_list": "", "function": "Hydrophilin which is essential to overcome the simple stress of the desiccation-rehydration process., [UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Z7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0042631 cellular response to water deprivation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53872-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53874-1", "uniprot_id": "UBP10_YEAST", "mass": 88531.0, "length": 792, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 10", "gene_name": "UBP10", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP10", "refseq_ac": "NP_014213", "gene_names_uniprotkb": "UBP10; DOT4; N1619", "gene_names_refseq": "DOT4; UBP10", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 10; 3.4.19.12; Deubiquitinating enzyme 10; Disrupter of telomere silencing protein 4; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10", "protein_names_refseq": "ubiquitin-specific protease UBP10", "tax_id": 559292, "disease": "autosomal dominant nonsyndromic deafness 85 (Disease Ontology:DOID:0070605); congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (sce:YNL186W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10490600;11352638;14623890;15721261;15988024;17028327;19779198;19795423;19823750;20702584;21126336;21725298;22031224;22056669;22829782;22902402;24374639;26149687;32597660;33481703;33491328;9169873;9755194", "class_list": "", "function": "Deubiquitinating enzyme involved in telomere and HM loci silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes (PubMed:10490600, PubMed:14623890, PubMed:9755194). Targets histone H2B for deubiquitination, thus helping to localize SIR2 to the telomere (PubMed:15721261, PubMed:17028327, PubMed:22056669). At silent chromatin, including telomeres and the rDNA locus, not only maintains low H2B 'Lys-123' ubiquitination (H2BK123Ub), but also low H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively) (PubMed:15721261, PubMed:15988024). Controls the proliferating-cell nuclear antigen PCNA/POL30 deubiquitination which is crucial for keeping TLS polymerases in check as well as for down-regulating the error-free bypass (PubMed:22829782). Deubiquitinates and stabilizes RPA190, the largest subunit of RNA polymerase I, to achieve optimal levels of ribosomes and cell growth (PubMed:22902402). Also protects nutrient transporters such as GAP1 from ubiquitin-dependent endocytosis (PubMed:11352638)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W101", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0033567 DNA replication, Okazaki fragment processing", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P53874-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53890-1", "uniprot_id": "BNI5_YEAST", "mass": 49694.0, "length": 448, "protein_name": "Bud neck protein 5", "gene_name": "BNI5", "organism": "Yeast", "refseq_name": "Bni5p", "refseq_ac": "NP_014233", "gene_names_uniprotkb": "BNI5; N1706", "gene_names_refseq": "BNI5", "protein_names_uniprotkb": "Bud neck protein 5", "protein_names_refseq": "Bni5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL166C)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "11875433;12058072;12215547;14562095;15665377;17287358;17330950;17342053;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;24909858;25971666;30516470;32597660;33229814;33481703;33491328;8686380;9169873", "class_list": "", "function": "Required for normal septin function and cytokinesis (PubMed:12215547). Its recruitment to the bud neck by CDCd11 and SHS1 ensures efficient localization at the bud neck of MYO1, the type II myosin of the actomyosin contractile ring (PubMed:25971666)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6W116", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0032035 myosin II tail binding", "go_cellular_component": "GO:0000144 cellular bud neck septin ring;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0000921 septin ring assembly;GO:0072741 protein localization to cell division site", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P53890-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53893-1", "uniprot_id": "RIA1_YEAST", "mass": 124464.0, "length": 1110, "protein_name": "Ribosome assembly protein 1", "gene_name": "RIA1", "organism": "Yeast", "refseq_name": "GTPase RIA1", "refseq_ac": "NP_014236", "gene_names_uniprotkb": "RIA1; EFL1; N1718", "gene_names_refseq": "EFL1; RIA1", "protein_names_uniprotkb": "Ribosome assembly protein 1; 3.6.5.-; EF-2-like GTPase; Elongation factor-like 1", "protein_names_refseq": "GTPase RIA1", "tax_id": 559292, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (sce:YNL163C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11713675;11779510;14562095;14562106;16095611;17563356;18407956;19779198;20702584;21126336;22218487;23749301;24374639;32597660;33481703;33491328;8686380;9169873", "class_list": "", "function": "GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SDO1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W119", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0042256 cytosolic ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P53893-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53895-1", "uniprot_id": "ASI2_YEAST", "mass": 32986.0, "length": 289, "protein_name": "Protein ASI2", "gene_name": "ASI2", "organism": "Yeast", "refseq_name": "Asi2p", "refseq_ac": "NP_014240", "gene_names_uniprotkb": "ASI2; N1735", "gene_names_refseq": "ASI2", "protein_names_uniprotkb": "Protein ASI2; Amino acid sensor-independent protein 2", "protein_names_refseq": "Asi2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL159C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11454748;16847258;17085444;23749301;24374639;25236469;33481703;33491328;8686380;9169873", "class_list": "", "function": "Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation (PubMed:25236469). Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444). Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W124", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005637 nuclear inner membrane;GO:0097658 Asi complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P53895-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53896-1", "uniprot_id": "PGA1_YEAST", "mass": 22383.0, "length": 198, "protein_name": "GPI mannosyltransferase 2 subunit PGA1", "gene_name": "PGA1", "organism": "Yeast", "refseq_name": "Pga1p", "refseq_ac": "NP_014241", "gene_names_uniprotkb": "PGA1; N1739", "gene_names_refseq": "PGA1", "protein_names_uniprotkb": "GPI mannosyltransferase 2 subunit PGA1; Processing of GAS1 and ALP protein 1", "protein_names_refseq": "Pga1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL158W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;16847258;17615295;24374639;8686380;9169873", "class_list": "", "function": "Essential component of the GPI mannosyltransferase 2 complex. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W125", "ec_number_list": "", "go_molecular_function": "GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0031501 mannosyltransferase complex;GO:0005635 nuclear envelope;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53897-1", "uniprot_id": "IGO1_YEAST", "mass": 18051.0, "length": 168, "protein_name": "mRNA stability protein IGO1", "gene_name": "IGO1", "organism": "Yeast", "refseq_name": "phosphatase regulator", "refseq_ac": "NP_014242", "gene_names_uniprotkb": "IGO1; N1743", "gene_names_refseq": "IGO1", "protein_names_uniprotkb": "mRNA stability protein IGO1; Initiation of G zero protein 1", "protein_names_refseq": "phosphatase regulator", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL157W); (R-SCE-2465910)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "17322287;17330950;18407956;19779198;19795423;19823750;20471941;20702584;21126336;21177495;22218487;23749301;23861665;24374639;24909858;24968058;26447709;28600888;31765390;32597660;33481703;33491328;34965436;8686380;9169873", "class_list": "", "function": "Required for TORC1 to properly control gene expression and chronological life span. Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W126", "ec_number_list": "", "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0048255 mRNA stabilization;GO:1903452 positive regulation of G1 to G0 transition;GO:1901992 positive regulation of mitotic cell cycle phase transition;GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P53897-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53899-1", "uniprot_id": "CUZ1_YEAST", "mass": 31517.0, "length": 274, "protein_name": "CDC48-associated ubiquitin-like/zinc finger protein 1", "gene_name": "CUZ1", "organism": "Yeast", "refseq_name": "Cuz1p", "refseq_ac": "NP_014244", "gene_names_uniprotkb": "CUZ1; N1751", "gene_names_refseq": "CUZ1", "protein_names_uniprotkb": "CDC48-associated ubiquitin-like/zinc finger protein 1; CDC48-associated UBL/Zn-finger protein 1", "protein_names_refseq": "Cuz1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL155W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562095;14562106;17322287;17563356;18407956;19684113;19779198;20702584;23749301;24121501;24297164;24374639;29804830;32597660;33481703;33491328;8686380;9169873", "class_list": "", "function": "Promotes efficient arsenite-induced clearance of stress granules (SGs) (PubMed:29804830). May have a role in the ubiquitin-proteasome system (UPS) protecting cells from metalloid-induced proteotoxicity (PubMed:24121501, PubMed:24297164)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W128", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0071243 cellular response to arsenic-containing substance;GO:0035617 stress granule disassembly;GO:1903843 cellular response to arsenite ion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P53899-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53904-1", "uniprot_id": "TBCB_YEAST", "mass": 28354.0, "length": 254, "protein_name": "Tubulin-specific chaperone B", "gene_name": "ALF1", "organism": "Yeast", "refseq_name": "Alf1p", "refseq_ac": "NP_014251", "gene_names_uniprotkb": "ALF1; N1201; N1777", "gene_names_refseq": "ALF1", "protein_names_uniprotkb": "Tubulin-specific chaperone B; Alpha-tubulin formation protein 1; Tubulin-folding cofactor B", "protein_names_refseq": "Alf1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL148C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;24374639;33481703;33491328;8619318;8686380;9169873;9885248", "class_list": "", "function": "Acts to sequester alpha-tubulin from interaction with beta-tubulin, raising the possibility that it plays a regulatory role in the formation of the tubulin heterodimer., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W134", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0006457 protein folding;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53904-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53911-1", "uniprot_id": "EAF7_YEAST", "mass": 49391.0, "length": 425, "protein_name": "Chromatin modification-related protein EAF7", "gene_name": "EAF7", "organism": "Yeast", "refseq_name": "Eaf7p", "refseq_ac": "NP_014263", "gene_names_uniprotkb": "EAF7; N1212; N1843", "gene_names_refseq": "EAF7", "protein_names_uniprotkb": "Chromatin modification-related protein EAF7; ESA1-associated factor 7", "protein_names_refseq": "Eaf7p", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (sce:YNL136W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11875433;14562095;14562106;15353583;17287358;17563356;18407956;19795423;19823750;20489023;21177495;23749301;24374639;32597660;33481703;33491328;8619318;9169873", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W146", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006335 DNA replication-dependent chromatin assembly;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P53911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53915-1", "uniprot_id": "NRK1_YEAST", "mass": 27690.0, "length": 240, "protein_name": "Nicotinamide riboside kinase", "gene_name": "NRK1", "organism": "Yeast", "refseq_name": "ribosylnicotinamide kinase", "refseq_ac": "NP_014270", "gene_names_uniprotkb": "NRK1; N1219; N1870", "gene_names_refseq": "NRK1", "protein_names_uniprotkb": "Nicotinamide riboside kinase; 2.7.1.173; 2.7.1.22; NRK; Nicotinic acid riboside kinase; NmR-K; RNK; Ribosylnicotinamide kinase; Ribosylnicotinic acid kinase", "protein_names_refseq": "ribosylnicotinamide kinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL129W); (R-SCE-196807)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "14562106;15137942;17322287;24374639;8619318;9169873", "class_list": "", "function": "Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W154", "ec_number_list": "2.7.1.173;2.7.1.22", "go_molecular_function": "GO:0050262 ribosylnicotinamide kinase activity;GO:0061769 nicotinate riboside kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:0046495 nicotinamide riboside metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53917-1", "uniprot_id": "FAR11_YEAST", "mass": 109793.0, "length": 953, "protein_name": "Factor arrest protein 11", "gene_name": "FAR11", "organism": "Yeast", "refseq_name": "Far11p", "refseq_ac": "NP_014272", "gene_names_uniprotkb": "FAR11; N1221; N1875", "gene_names_refseq": "FAR11", "protein_names_uniprotkb": "Factor arrest protein 11", "protein_names_refseq": "Far11p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL127W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12588993;14562106;15665377;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;32597660;33481703;33491328;8619318;8913737;9090055;9169873", "class_list": "", "function": "Participates in the control of the reentry into the cell cycle following pheromone treatment., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W156", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0000138 Golgi trans cisterna", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0007010 cytoskeleton organization;GO:0016239 positive regulation of macroautophagy;GO:0035331 negative regulation of hippo signaling;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P53917-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53920-1", "uniprot_id": "NM111_YEAST", "mass": 110881.0, "length": 997, "protein_name": "Pro-apoptotic serine protease NMA111", "gene_name": "NMA111", "organism": "Yeast", "refseq_name": "Nma111p", "refseq_ac": "NP_014276", "gene_names_uniprotkb": "NMA111; N1897; YNM3", "gene_names_refseq": "NMA111; YNM3", "protein_names_uniprotkb": "Pro-apoptotic serine protease NMA111; 111 kDa nuclear mediator of apoptosis; 3.4.21.-", "protein_names_refseq": "Nma111p", "tax_id": 559292, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); patterned macular dystrophy (Disease Ontology:DOID:0060863); autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0061228); 3-methylglutaconic aciduria type 8 (Disease Ontology:DOID:0070000); age related macular degeneration 7 (Disease Ontology:DOID:0110019); autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0111036); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); esophageal carcinoma (Disease Ontology:DOID:1107); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (sce:YNL123W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562095;14562106;14645503;14657274;16608876;18407956;18780730;19779198;20190278;21126336;22814378;23749301;24374639;32597660;33481703;33491328;8962070;9090055;9169873", "class_list": "", "function": "Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0KZR3;B0KZU0;B0KZX6;B0L003;B0L021;D6W160", "ec_number_list": "", "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0034605 cellular response to heat;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P53920-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53924-1", "uniprot_id": "DMA2_YEAST", "mass": 57584.0, "length": 522, "protein_name": "E3 ubiquitin-protein ligase DMA2", "gene_name": "DMA2", "organism": "Yeast", "refseq_name": "ubiquitin-conjugating protein DMA2", "refseq_ac": "NP_014283", "gene_names_uniprotkb": "DMA2; CHF2; N1925", "gene_names_refseq": "CHF2; DMA2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DMA2; 2.3.2.27; Checkpoint forkhead associated with RING domains-containing protein 1; Defective in mitotic arrest protein 2; RING-type E3 ubiquitin transferase DMA2", "protein_names_refseq": "ubiquitin-conjugating protein DMA2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL116W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;15146058;15319434;18202552;18407956;18780730;23749301;24374639;32597660;33229814;33481703;33491328;9090055;9169873", "class_list": "", "function": "E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes. Involved in nutritional control of the cell cycle. Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "B0KZS8;B0KZU6;B0KZW4;B0L009;D6W166;Q66GT0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex;GO:0032153 cell division site;GO:0005934 cellular bud tip", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0000921 septin ring assembly;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P53924-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53935-1", "uniprot_id": "NST1_YEAST", "mass": 141514.0, "length": 1240, "protein_name": "Stress response protein NST1", "gene_name": "NST1", "organism": "Yeast", "refseq_name": "Nst1p", "refseq_ac": "NP_014308", "gene_names_uniprotkb": "NST1; N2231", "gene_names_refseq": "NST1", "protein_names_uniprotkb": "Stress response protein NST1; Negatively-affecting salt tolerance protein 1", "protein_names_refseq": "Nst1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL091W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11816027;14562095;14562106;16273108;17330950;18407956;19779198;19795423;19823750;22814378;23749301;24374639;30516470;33229814;33481703;33491328;8771715;9169873", "class_list": "", "function": "With MSL1, acts as a negative regulator of salt tolerance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W189;Q45TZ3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0009651 response to salt stress", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P53935-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53942-1", "uniprot_id": "RNH2A_YEAST", "mass": 34875.0, "length": 307, "protein_name": "Ribonuclease H2 subunit A", "gene_name": "RNH201", "organism": "Yeast", "refseq_name": "ribonuclease H2 catalytic subunit RNH201", "refseq_ac": "NP_014327", "gene_names_uniprotkb": "RNH201; N2369; RNH35", "gene_names_refseq": "RNH201; RNH35", "protein_names_uniprotkb": "Ribonuclease H2 subunit A; 3.1.26.4; RNase H(201); RNase H(35); RNase H2 subunit A; RNase HI large subunit; Ribonuclease HI large subunit; Ribonuclease HI subunit A", "protein_names_refseq": "ribonuclease H2 catalytic subunit RNH201", "tax_id": 559292, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (sce:YNL072W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;14734815;24374639;33491328;8701611;9169873;9462832", "class_list": "", "function": "Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1A7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0043137 DNA replication, removal of RNA primer", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53942-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53949-1", "uniprot_id": "OCA2_YEAST", "mass": 22472.0, "length": 197, "protein_name": "Tyrosine-protein phosphatase-like protein OCA2", "gene_name": "OCA2", "organism": "Yeast", "refseq_name": "Oca2p", "refseq_ac": "NP_014342", "gene_names_uniprotkb": "OCA2; N2439; YNL2439W", "gene_names_refseq": "OCA2", "protein_names_uniprotkb": "Tyrosine-protein phosphatase-like protein OCA2; Oxidant-induced cell-cycle arrest protein 2", "protein_names_refseq": "Oca2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL056W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;17322287;17330950;18407956;19684113;19779198;19795423;24374639;33491328;8533472;9169873", "class_list": "", "function": "Required for normal growth in the presence of linoleic acid hydroperoxide (LoaOOH)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1C2;Q6B2U7", "ec_number_list": "", "go_molecular_function": "GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53949-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53950-1", "uniprot_id": "VAC7_YEAST", "mass": 128140.0, "length": 1165, "protein_name": "Vacuolar segregation protein 7", "gene_name": "VAC7", "organism": "Yeast", "refseq_name": "Vac7p", "refseq_ac": "NP_014344", "gene_names_uniprotkb": "VAC7; N2467; YNL2467W", "gene_names_refseq": "VAC7", "protein_names_uniprotkb": "Vacuolar segregation protein 7", "protein_names_refseq": "Vac7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL054W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11950935;16492811;17563356;18407956;19037259;19756047;19779198;19795423;19823750;23749301;24374639;28637746;32597660;33229814;33481703;33491328;8533472;9169873;9372916", "class_list": "", "function": "The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Positively regulates FAB1 kinase activity. Major activator of FAB1 during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of VAC14 and FIG4. Directly involved in vacuolar membrane scission. Required for normal vacuole acidification, inheritance and morphology., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6W1C5", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005774 vacuolar membrane;GO:0070772 PAS complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0010513 positive regulation of phosphatidylinositol biosynthetic process;GO:1903778 protein localization to vacuolar membrane;GO:0000011 vacuole inheritance;GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process;GO:0010511 regulation of phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P53950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53965-1", "uniprot_id": "SIW14_YEAST", "mass": 32755.0, "length": 281, "protein_name": "Inositol diphosphatase SIW14", "gene_name": "SIW14", "organism": "Yeast", "refseq_name": "putative tyrosine protein phosphatase SIW14", "refseq_ac": "NP_014366", "gene_names_uniprotkb": "SIW14; N2746; OCA3", "gene_names_refseq": "OCA3; SIW14", "protein_names_uniprotkb": "Inositol diphosphatase SIW14; 3.6.1.52; 5-PP-InsP phosphatase; Inositol pyrophosphate phosphatase SIW14; Oxidant-induced cell-cycle arrest protein 3; Synthetic interaction with WHI2 protein 14", "protein_names_refseq": "putative tyrosine protein phosphatase SIW14", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL032W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562095;14562106;15020461;17330950;17563356;18407956;19779198;21409566;24374639;26828065;28923943;29540476;30548067;32597660;33481703;33491328;35640071;9169873", "class_list": "", "function": "Selectively cleaves the beta-phosphate at the 5-position of soluble inositol pyrophosphates. Converts 5-diphosphoinositol tetrakisphosphate (5-PP-InsP(4)) into inositol pentakisphosphate (InsP(5)), 5-diphosphoinositol pentakisphosphate (5-PP-IP(5) or 5-InsP(7)) into inositol hexakisphosphate (IP(6) or InsP(6)), and 1,5-bisdiphosphoinositol tetrakisphosphate (1,5-PP-IP(5) or InsP(8)) into 1-diphosphoinositol pentakisphosphate (1-PP-IP(5) or 1-InsP(7)) (PubMed:26828065, PubMed:29540476, PubMed:35640071). Also has activity on 1,5-bis-diphosphoinositol 2,3,4,6-tetrakisphosphate (1,5-InsP(8)) and 3,5-InsP(8) (PubMed:35640071). Modulates inositol pyrophosphate metabolism that may have an influence in stress response (PubMed:26828065). Plays a role in actin filament organization and endocytosis (PubMed:15020461). Functions as a prion suppressing factor possibly due to its phosphatase activity against inositol pyrophosphates, which are signal transduction molecules involved in prion propagation (PubMed:28923943)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1E7", "ec_number_list": "3.6.1.52", "go_molecular_function": "GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity;GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity;GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P53965-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53968-1", "uniprot_id": "CRZ1_YEAST", "mass": 76301.0, "length": 678, "protein_name": "Transcriptional regulator CRZ1", "gene_name": "CRZ1", "organism": "Yeast", "refseq_name": "DNA-binding transcription factor CRZ1", "refseq_ac": "NP_014371", "gene_names_uniprotkb": "CRZ1; HAL8; N2760; TCN1", "gene_names_refseq": "CRZ1; HAL8; TCN1", "protein_names_uniprotkb": "Transcriptional regulator CRZ1", "protein_names_refseq": "DNA-binding transcription factor CRZ1", "tax_id": 559292, "disease": "patent ductus arteriosus (Disease Ontology:DOID:13832)", "pathway": " (sce:YNL027W); (R-SCE-3232118); (R-SCE-6807505)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10197980;14562106;15470242;16455487;17287358;17563356;18407956;19779198;20489023;21177495;23749301;24374639;32597660;33481703;33491328;34965436;9169873;9407036", "class_list": "", "function": "Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates PMC1, PMR1, PMR2A and FKS2., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 33, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1F1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071469 cellular response to alkaline pH;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P53968-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53972-1", "uniprot_id": "RCM1_YEAST", "mass": 56177.0, "length": 490, "protein_name": "25S rRNA (cytosine(2278)-C(5))-methyltransferase", "gene_name": "RCM1", "organism": "Yeast", "refseq_name": "rRNA (cytosine-C5-)-methyltransferase RCM1", "refseq_ac": "NP_014376", "gene_names_uniprotkb": "RCM1; N2815", "gene_names_refseq": "RCM1", "protein_names_uniprotkb": "25S rRNA (cytosine(2278)-C(5))-methyltransferase; 2.1.1.311; rRNA m(5)C methyltransferase 1", "protein_names_refseq": "rRNA (cytosine-C5-)-methyltransferase RCM1", "tax_id": 559292, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (sce:YNL022C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10649453;14562106;22956767;23913415;24374639;25125595;25635753;33491328;9169873", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2278 (m5C2278) in 25S rRNA (PubMed:23913415, PubMed:25125595, PubMed:25635753). Loss of m5C2278 in 25S rRNA results in anisomycin hypersensitivity (PubMed:23913415)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1F7", "ec_number_list": "2.1.1.311", "go_molecular_function": "GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0070475 rRNA base methylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53972-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53973-1", "uniprot_id": "HDA1_YEAST", "mass": 80070.0, "length": 706, "protein_name": "Histone deacetylase HDA1", "gene_name": "HDA1", "organism": "Yeast", "refseq_name": "histone deacetylase HDA1", "refseq_ac": "NP_014377", "gene_names_uniprotkb": "HDA1; N2819", "gene_names_refseq": "HDA1", "protein_names_uniprotkb": "Histone deacetylase HDA1; 3.5.1.98", "protein_names_refseq": "histone deacetylase HDA1", "tax_id": 559292, "disease": "polycystic liver disease 1 (Disease Ontology:DOID:0060980); polycystic kidney disease (Disease Ontology:DOID:0080322); chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (Disease Ontology:DOID:0112106); hypertension (Disease Ontology:DOID:10763); ataxia telangiectasia (Disease Ontology:DOID:12704); Parkinson's disease (Disease Ontology:DOID:14330); impotence (Disease Ontology:DOID:1875); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); aortic aneurysm (Disease Ontology:DOID:3627); cholangiocarcinoma (Disease Ontology:DOID:4947); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466); eating disorder (Disease Ontology:DOID:8670); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YNL021W); (R-SCE-3371511)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562106;21177495;23749301;24374639;32597660;33481703;33491328;8962081;9169873", "class_list": "", "function": "Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1F8", "ec_number_list": "3.6.4.6;3.5.1.98", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0141221 histone deacetylase activity, hydrolytic mechanism", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000118 histone deacetylase complex;GO:0070823 HDA1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53973-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53978-1", "uniprot_id": "EF3B_YEAST", "mass": 115869.0, "length": 1044, "protein_name": "Elongation factor 3B", "gene_name": "HEF3", "organism": "Yeast", "refseq_name": "translation elongation factor EF-3", "refseq_ac": "NP_014384", "gene_names_uniprotkb": "HEF3; N2846; YEF3B; ZRG7", "gene_names_refseq": "HEF3; ZRG7", "protein_names_uniprotkb": "Elongation factor 3B; 3.6.4.-; EF-3B; Eukaryotic elongation factor 3B; Homolog of EF-3; Translation elongation factor 3B; eEF3", "protein_names_refseq": "translation elongation factor EF-3", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL014W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;17287358;20702584;24374639;33260587;33491328;9169873;9544245;9778796", "class_list": "", "function": "Ribosome-dependent ATPase that promotes the translation of proteins required for detoxification of reactive oxygen species (PubMed:33260587). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity). Assists translation termination by stimulating the release of nascent protein from the ribosome by release factors (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1G4", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0006414 translational elongation;GO:0002182 cytoplasmic translational elongation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53978-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53981-1", "uniprot_id": "PYP1_YEAST", "mass": 27481.0, "length": 241, "protein_name": "Polyol phosphate phosphatase PYP1", "gene_name": "PYP1", "organism": "Yeast", "refseq_name": "putative phosphoric monoester hydrolase", "refseq_ac": "NP_014388", "gene_names_uniprotkb": "PYP1; N2866", "gene_names_refseq": "PYP1", "protein_names_uniprotkb": "Polyol phosphate phosphatase PYP1; 3.1.3.50", "protein_names_refseq": "putative phosphoric monoester hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL010W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;23749301;24374639;30240188;33491328;9169873", "class_list": "", "function": "Hydrolyzes sugar alcohol (polyol) phosphates (PubMed:30240188). Dephosphorylates a variety of substrates, including: sn-glycerol 1-phosphate (D-glycerol 3-phosphate), D-ribitol 5-phosphate, D-sorbitol 6-phosphate (D-glucitol 6-phosphate), and D-erythrose 4-phosphate (PubMed:30240188). Prevents accumulation of toxic levels of polyol phosphates, which can impair glycolysis by inhibiting glucose-6-phosphate isomerase (PubMed:30240188)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1G7", "ec_number_list": "3.1.3.21;3.1.3.50", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0000121 sn-glycerol 1-phosphatase activity;GO:0043136 sn-glycerol 3-phosphatase activity;GO:0050286 sorbitol-6-phosphatase activity;GO:0110130 ribitol-5-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0052646 alditol phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P53981-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53983-1", "uniprot_id": "ASI3_YEAST", "mass": 77649.0, "length": 676, "protein_name": "Probable ERAD-associated E3 ubiquitin-protein ligase ASI1", "gene_name": "ASI3", "organism": "Yeast", "refseq_name": "putative ubiquitin-protein ligase ASI3", "refseq_ac": "NP_014390", "gene_names_uniprotkb": "ASI3; N2874", "gene_names_refseq": "ASI3", "protein_names_uniprotkb": "Probable ERAD-associated E3 ubiquitin-protein ligase ASI1; 2.3.2.27; Amino acid sensor-independent protein 3", "protein_names_refseq": "putative ubiquitin-protein ligase ASI3", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL008C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11454748;14562095;16847258;17085444;24374639;25236469;33481703;33491328;9169873", "class_list": "", "function": "Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation (PubMed:25236469). Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444). Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W1G9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0034399 nuclear periphery;GO:0005637 nuclear inner membrane;GO:0097658 Asi complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P53983-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54003-1", "uniprot_id": "SUR7_YEAST", "mass": 33830.0, "length": 302, "protein_name": "Protein SUR7", "gene_name": "SUR7", "organism": "Yeast", "refseq_name": "Sur7p", "refseq_ac": "NP_013660", "gene_names_uniprotkb": "SUR7; YM9958.11", "gene_names_refseq": "SUR7", "protein_names_uniprotkb": "Protein SUR7", "protein_names_refseq": "Sur7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML052W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "11784867;11875433;12469340;14562095;14562106;15536122;16496001;16847258;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169872;9219339", "class_list": "", "function": "Involved in sporulation and affects the sphingolipid composition of the plasma membrane. Probably involved in endocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZC3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0045121 membrane raft;GO:0071944 cell periphery", "go_biological_process": "GO:0006897 endocytosis;GO:0030866 cortical actin cytoskeleton organization;GO:0032185 septin cytoskeleton organization;GO:0030437 ascospore formation;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P54003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54070-1", "uniprot_id": "KTR6_YEAST", "mass": 52128.0, "length": 446, "protein_name": "Mannosyltransferase KTR6", "gene_name": "KTR6", "organism": "Yeast", "refseq_name": "putative mannosyltransferase", "refseq_ac": "NP_015272", "gene_names_uniprotkb": "KTR6; LPE19C; MNN6", "gene_names_refseq": "KTR6; MNN6", "protein_names_uniprotkb": "Mannosyltransferase KTR6; 2.4.1.-; Mannosylphosphate transferase MNN6", "protein_names_refseq": "putative mannosyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL053C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;24374639;9090056;9169875;9218445", "class_list": "", "function": "Glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. Required for addition of mannosylphosphate in yeast mannan. Recognizes any oligosaccharides with at least one alpha-1,2-linked mannobiose unit., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W3W1", "ec_number_list": "", "go_molecular_function": "GO:0000026 alpha-1,2-mannosyltransferase activity;GO:0000031 mannosylphosphate transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0006493 protein O-linked glycosylation;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006487 protein N-linked glycosylation;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54070-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54074-1", "uniprot_id": "ASI1_YEAST", "mass": 71444.0, "length": 624, "protein_name": "ERAD-associated E3 ubiquitin-protein ligase ASI1", "gene_name": "ASI1", "organism": "Yeast", "refseq_name": "putative ubiquitin-protein ligase ASI1", "refseq_ac": "NP_013837", "gene_names_uniprotkb": "ASI1; YM8564.01; YM9718.18", "gene_names_refseq": "ASI1", "protein_names_uniprotkb": "ERAD-associated E3 ubiquitin-protein ligase ASI1; 2.3.2.27; Amino acid sensor-independent protein 1", "protein_names_refseq": "putative ubiquitin-protein ligase ASI1", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR119W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11454748;14562095;16735580;16847258;17085444;24374639;25236469;27831485;9169872", "class_list": "", "function": "E3 ubiquitin-protein ligase which transfers ubiquitin to substrates promoting their degradation. Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain. Required for ERG11 degradation (PubMed:25236469). Negative regulator of SPS-sensor signaling. Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:16735580, PubMed:17085444). Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VZU2", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0034399 nuclear periphery;GO:0005637 nuclear inner membrane;GO:0097658 Asi complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P54074-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54115-1", "uniprot_id": "ALDH6_YEAST", "mass": 54414.0, "length": 500, "protein_name": "Magnesium-activated aldehyde dehydrogenase, cytosolic", "gene_name": "ALD6", "organism": "Yeast", "refseq_name": "aldehyde dehydrogenase (NADP(+)) ALD6", "refseq_ac": "NP_015264", "gene_names_uniprotkb": "ALD6; ALDH1; LPE9", "gene_names_refseq": "ALD1; ALD6", "protein_names_uniprotkb": "Magnesium-activated aldehyde dehydrogenase, cytosolic; 1.2.1.4; Mg(2+)-ACDH; Mg(2+)-activated acetaldehyde dehydrogenase", "protein_names_refseq": "aldehyde dehydrogenase (NADP(+)) ALD6", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); isolated microphthalmia 8 (Disease Ontology:DOID:0060841); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); DiGeorge syndrome (Disease Ontology:DOID:11198); heart disease (Disease Ontology:DOID:114); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic cancer (Disease Ontology:DOID:1793); brain infarction (Disease Ontology:DOID:3454); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); liver disease (Disease Ontology:DOID:409); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (sce:YPL061W); (R-SCE-380612); (R-SCE-5365859); (R-SCE-70350); (R-SCE-71384); (R-SCE-9837999)", "pathway_count": 6, "publication_count": 23, "publication_id_list": "12872131;14562106;17287358;17330950;18407956;19779198;19795423;19823750;21126336;21177495;22106047;22218487;23749301;24374639;30516470;32597660;33481703;33491328;34965436;9038161;9169875;9392076;9473035", "class_list": "", "function": "Cytosolic aldehyde dehydrogenase which utilizes NADP(+) as the preferred coenzyme. Performs the conversion of acetaldehyde to acetate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3V3;Q02782", "ec_number_list": "3.5.3.1;7.1.2.2;2.3.3.1;4.2.1.2;3.6.4.10;4.98.1.1;4.2.1.3;1.2.4.2;1.1.1.37;1.2.4.1;3.4.21.53;2.3.1.41;1.2.1.4;1.2.1.5;6.1.1.5;2.3.3.10", "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0140088 acetaldehyde dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006068 ethanol catabolic process;GO:0009651 response to salt stress;GO:0019413 acetate biosynthetic process;GO:0006740 NADPH regeneration", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P54115-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54780-1", "uniprot_id": "RL15B_YEAST", "mass": 24422.0, "length": 204, "protein_name": "Large ribosomal subunit protein eL15B", "gene_name": "RPL15B", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL15 RPL15B", "refseq_ac": "NP_013840", "gene_names_uniprotkb": "RPL15B; RPL10B; RPL13B; YL10B; YM8564.03C", "gene_names_refseq": "RPL15B", "protein_names_uniprotkb": "Large ribosomal subunit protein eL15B; 60S ribosomal protein L15-B; L13; RP15R; YL10; YP18", "protein_names_refseq": "60S ribosomal protein eL15 RPL15B", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 12 (Disease Ontology:DOID:0111882)", "pathway": " (sce:YMR121C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 9, "publication_id_list": "14562106;1544921;22096102;22814378;24374639;24524803;6814480;9169872;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZU4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0016236 macroautophagy;GO:0002181 cytoplasmic translation;GO:0000470 maturation of LSU-rRNA;GO:0180023 cytosolic large ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P54780-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54781-1", "uniprot_id": "ERG5_YEAST", "mass": 61334.0, "length": 538, "protein_name": "C-22 sterol desaturase ERG5", "gene_name": "ERG5", "organism": "Yeast", "refseq_name": "C-22 sterol desaturase", "refseq_ac": "NP_013728", "gene_names_uniprotkb": "ERG5; CYP61; YM9711.02C", "gene_names_refseq": "CYP61; ERG5", "protein_names_uniprotkb": "C-22 sterol desaturase ERG5; 1.14.19.41; Cytochrome P450 61; Ergosterol biosynthetic protein 5", "protein_names_refseq": "C-22 sterol desaturase", "tax_id": 559292, "disease": "osteochondrodysplasia (Disease Ontology:DOID:2256); craniosynostosis (Disease Ontology:DOID:2340); holoprosencephaly (Disease Ontology:DOID:4621); hepatocellular carcinoma (Disease Ontology:DOID:684); Barrett's adenocarcinoma (Disease Ontology:DOID:7941); actinic keratosis (Disease Ontology:DOID:8866)", "pathway": " (sce:YMR015C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12872131;14562106;15995173;17322287;23749301;24374639;32679672;33481703;33491328;37604855;8543054;8635732;9169872", "class_list": "", "function": "C-22 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:8543054, PubMed:8635732). ERG5 converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain (PubMed:8543054, PubMed:8635732). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZI9;E9P965", "ec_number_list": "1.14.19.41", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0000249 C-22 sterol desaturase (NADPH) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P54781-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54783-1", "uniprot_id": "ALO_YEAST", "mass": 59494.0, "length": 526, "protein_name": "D-arabinono-1,4-lactone oxidase", "gene_name": "ALO1", "organism": "Yeast", "refseq_name": "D-arabinono-1,4-lactone oxidase", "refseq_ac": "NP_013624", "gene_names_uniprotkb": "ALO1", "gene_names_refseq": "ALO1", "protein_names_uniprotkb": "D-arabinono-1,4-lactone oxidase; 1.1.3.37; ALO; L-galactono-gamma-lactone oxidase", "protein_names_refseq": "D-arabinono-1,4-lactone oxidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YML086C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10094636;14562106;17322287;19795423;19823750;21126336;23749301;24374639;33481703;33491328;9169872", "class_list": "", "function": "Can oxidize L-gulono-1,4-lactone as well as D-arabinono-1,4-lactone and L-galactono-1,4-lactone., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0J7;O42618", "ec_number_list": "1.1.3.37", "go_molecular_function": "GO:0071949 FAD binding;GO:0031489 myosin V binding;GO:0003885 D-arabinono-1,4-lactone oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0032473 cytoplasmic side of mitochondrial outer membrane", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0070485 dehydro-D-arabinono-1,4-lactone biosynthetic process;GO:0000001 mitochondrion inheritance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P54783-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54785-1", "uniprot_id": "MOT3_YEAST", "mass": 54382.0, "length": 490, "protein_name": "Transcriptional activator/repressor MOT3", "gene_name": "MOT3", "organism": "Yeast", "refseq_name": "Mot3p", "refseq_ac": "NP_013786", "gene_names_uniprotkb": "MOT3; ROX7; YM9916.09", "gene_names_refseq": "MOT3; ROX7", "protein_names_uniprotkb": "Transcriptional activator/repressor MOT3; Hypoxic gene repressor protein 7; Modulator of transcription protein 3", "protein_names_refseq": "Mot3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR070W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10982825;12145211;14530431;14562106;15821125;17322287;19345193;22814378;24374639;9169872;9528759;9611199", "class_list": "", "function": "Transcription factor that affects the expression of a large set of genes. Recognizes and binds to the consensus sequence 5'-[CAT]AGG[TC]A-3' in the promoter region. Plays a major role in the repression of a specific subset of hypoxic genes (e.g. ANB1, DAN1 and HEM13) under aerobic conditions. Acts synergistically with the transcription factor ROX1 to recruit the general repression complex SSN6-TUP1 to the promoter of hypoxic genes. Represses transcription of ergosterol biosynthetic genes. Negatively regulates pheromone-induced gene expression. Can act as a transcriptional activator (e.g. of genes like CYC1, SUC2 and the Ty long terminal repeat delta promoter)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZP4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071474 cellular hyperosmotic response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P54785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54787-1", "uniprot_id": "VPS9_YEAST", "mass": 52483.0, "length": 451, "protein_name": "Vacuolar protein sorting-associated protein 9", "gene_name": "VPS9", "organism": "Yeast", "refseq_name": "guanine nucleotide exchange factor VPS9", "refseq_ac": "NP_013612", "gene_names_uniprotkb": "VPS9; VPT9", "gene_names_refseq": "VPL31; VPS9; VPT9", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 9; Vacuolar protein-targeting protein 9", "protein_names_refseq": "guanine nucleotide exchange factor VPS9", "tax_id": 559292, "disease": "", "pathway": " (sce:YML097C); (R-SCE-8876198)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12628920;12787502;14562106;18407956;19795423;19823750;21126336;23749301;24374639;28270554;31208443;33481703;33491328;8628304;9169872", "class_list": "", "function": "Required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors. May bind a Rab GTPase such as VPS21., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0I8", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0036010 protein localization to endosome;GO:0006895 Golgi to endosome transport;GO:0000011 vacuole inheritance;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P54787-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54854-1", "uniprot_id": "HXT15_YEAST", "mass": 62931.0, "length": 567, "protein_name": "Hexose transporter HXT15", "gene_name": "HXT15", "organism": "Yeast", "refseq_name": "hexose transporter HXT15", "refseq_ac": "NP_010036", "gene_names_uniprotkb": "HXT15", "gene_names_refseq": "HLT2; HXT15", "protein_names_uniprotkb": "Hexose transporter HXT15", "protein_names_refseq": "hexose transporter HXT15", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL245C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16847258;19779198;24374639;8896264;9169867", "class_list": "", "function": "Probable glucose transporter., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRB2", "ec_number_list": "", "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0015797 mannitol transmembrane transport;GO:0008643 carbohydrate transport;GO:0008645 hexose transmembrane transport;GO:0015795 sorbitol transmembrane transport;GO:1902341 xylitol transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54854-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54857-1", "uniprot_id": "TGL2_YEAST", "mass": 37500.0, "length": 326, "protein_name": "Triacylglycerol lipase 2", "gene_name": "TGL2", "organism": "Yeast", "refseq_name": "triglyceride lipase", "refseq_ac": "NP_010343", "gene_names_uniprotkb": "TGL2; D4225; YD9609.12C", "gene_names_refseq": "TGL2", "protein_names_uniprotkb": "Triacylglycerol lipase 2; 3.1.1.3; Lipase 2; Neutral lipid hydrolase", "protein_names_refseq": "triglyceride lipase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR058C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17322287;19959834;24374639;28119444;31483742;33491328;8789263;9169867;9544243", "class_list": "", "function": "Mitochondrial triacylglycerol (TAG) lipase with activity toward long-chain diacylglycerols (DAGs) and triacylglycerols (TAGs) (PubMed:19959834, PubMed:9544243). Involved in mitochondrial lipid metabolism (PubMed:31483742)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS44;E9P8S6", "ec_number_list": "3.1.1.3;1.1.1.101", "go_molecular_function": "GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P54857-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54861-1", "uniprot_id": "DNM1_YEAST", "mass": 84972.0, "length": 757, "protein_name": "Dynamin-related protein DNM1", "gene_name": "DNM1", "organism": "Yeast", "refseq_name": "dynamin-related GTPase DNM1", "refseq_ac": "NP_013100", "gene_names_uniprotkb": "DNM1; L1381", "gene_names_refseq": "DNM1; DRP1", "protein_names_uniprotkb": "Dynamin-related protein DNM1; 3.6.5.5", "protein_names_refseq": "dynamin-related GTPase DNM1", "tax_id": 559292, "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 1 (Disease Ontology:DOID:0070347); optic atrophy 5 (Disease Ontology:DOID:0111438); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); dental fluorosis (Disease Ontology:DOID:13711); Parkinson's disease (Disease Ontology:DOID:14330); pulmonary fibrosis (Disease Ontology:DOID:3770); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YLL001W); (R-SCE-169911); (R-SCE-75153)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10559943;11038182;11553714;14517324;14562095;14562106;18407956;19779198;20702584;21126336;23530241;23749301;24374639;33481703;33491328;7622557;8810043;9169871", "class_list": "", "function": "Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY02", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;3.6.5.5;3.4.24.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0097753 membrane bending;GO:0016559 peroxisome fission;GO:0051260 protein homooligomerization;GO:0007031 peroxisome organization;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P54861-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54862-1", "uniprot_id": "HXT11_YEAST", "mass": 62733.0, "length": 567, "protein_name": "Hexose transporter HXT11", "gene_name": "HXT11", "organism": "Yeast", "refseq_name": "hexose transporter HXT11", "refseq_ac": "NP_014486", "gene_names_uniprotkb": "HXT11; AOB567; LGT3; O0414", "gene_names_refseq": "HXT11; LGT3", "protein_names_uniprotkb": "Hexose transporter HXT11; Low-affinity glucose transporter LGT3", "protein_names_refseq": "hexose transporter HXT11", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL156W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16847258;24374639;8810044;9169874", "class_list": "", "function": "Probable glucose transporter., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W1R4", "ec_number_list": "", "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0008643 carbohydrate transport;GO:0008645 hexose transmembrane transport;GO:1902341 xylitol transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54862-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54867-1", "uniprot_id": "SLG1_YEAST", "mass": 39270.0, "length": 378, "protein_name": "Protein SLG1", "gene_name": "SLG1", "organism": "Yeast", "refseq_name": "Slg1p", "refseq_ac": "NP_014650", "gene_names_uniprotkb": "SLG1; UNF378; WSC1", "gene_names_refseq": "HCS77; SLG1; WSC1", "protein_names_uniprotkb": "Protein SLG1; Cell wall integrity and stress response component 1; Synthetic lethal with GAP protein 1", "protein_names_refseq": "Slg1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR008C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10430578;10660075;11113201;12399379;14562106;15470108;15484288;15665377;17088254;17330950;17563356;18407956;19684113;19779198;19795423;19823750;22218487;23749301;24374639;32597660;33481703;33491328;8896276;9169874;9613583", "class_list": "", "function": "Plays a role during G1 to regulate entering or exiting the cell cycle. Involved in stress responses. Has a role in cell wall integrity signaling. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1. Important regulator of the actin cytoskeleton rearrangements in conditions of cell wall expansion and membrane stretching. Specifically required for the actin reorganization induced by hypo-osmotic shock. Multicopy suppressor of 1,3-beta-glucan synthase (GS). Activates GS upstream of RHO1. Acts positively on the PKC1-MAPK pathway. Activates transiently SLT2 during alkaline stress, which leads to an increase in the expression of several specific genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W274", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole;GO:0005933 cellular bud;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006897 endocytosis;GO:0006970 response to osmotic stress;GO:0007165 signal transduction;GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P54867-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P54999-1", "uniprot_id": "RUXF_YEAST", "mass": 9660.0, "length": 86, "protein_name": "Small nuclear ribonucleoprotein F", "gene_name": "SMX3", "organism": "Yeast", "refseq_name": "mRNA splicing protein SMX3", "refseq_ac": "NP_015508", "gene_names_uniprotkb": "SMX3; P9705.4", "gene_names_refseq": "SMX3", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein F; Sm protein F; Sm-F; SmF; snRNP-F", "protein_names_refseq": "mRNA splicing protein SMX3", "tax_id": 559292, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (sce:YPR182W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10369684;10449419;11302706;11804584;11884590;12618433;14562106;14690591;17322287;24374639;33491328;7744014;9012791;9169875;9528767", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4I2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008266 poly(U) RNA binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P54999-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P61829-1", "uniprot_id": "ATP9_YEAST", "mass": 7759.0, "length": 76, "protein_name": "ATP synthase subunit 9, mitochondrial", "gene_name": "OLI1", "organism": "Yeast", "refseq_name": "F0 ATP synthase subunit c", "refseq_ac": "NP_009319", "gene_names_uniprotkb": "OLI1; ATP9; OLI3; PHO2", "gene_names_refseq": "ATP9; OLI1; OLI3", "protein_names_uniprotkb": "ATP synthase subunit 9, mitochondrial; Lipid-binding protein; Oligomycin resistance protein 1", "protein_names_refseq": "F0 ATP synthase subunit c", "tax_id": 559292, "disease": "early-onset dystonia and/or spastic paraplegia (Disease Ontology:DOID:0070445); mitochondrial complex V (ATP synthase) deficiency (Disease Ontology:DOID:0111143); urinary bladder cancer (Disease Ontology:DOID:11054); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (sce:Q0130)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10576729;155696;156363;24374639;2860638;2894987;9872396", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7P075;P00841;Q37750", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P61829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P62651-1", "uniprot_id": "ERI1_YEAST", "mass": 8039.0, "length": 68, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase ERI1 subunit", "gene_name": "ERI1", "organism": "Yeast", "refseq_name": "Eri1p", "refseq_ac": "NP_690846", "gene_names_uniprotkb": "ERI1; RIN1", "gene_names_refseq": "ERI1; RIN1", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase ERI1 subunit; Endoplasmic reticulum-associated Ras inhibitor protein 1; GPI-GlcNAc transferase complex subunit ERI1; GPI-GnT subunit ERI1", "protein_names_refseq": "Eri1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL096C-A)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12832483;15163411;24374639;9169875", "class_list": "", "function": "Probable component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. Ras may inhibit the enzyme activity of the GPI-GnT complex via the association between ERI1 and RAS2., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3S0", "ec_number_list": "", "go_molecular_function": "GO:0005095 GTPase inhibitor activity", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0006506 GPI anchor biosynthetic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P69850-1", "uniprot_id": "DAD3_YEAST", "mass": 10848.0, "length": 94, "protein_name": "DASH complex subunit DAD3", "gene_name": "DAD3", "organism": "Yeast", "refseq_name": "Dad3p", "refseq_ac": "NP_631876", "gene_names_uniprotkb": "DAD3", "gene_names_refseq": "DAD3", "protein_names_uniprotkb": "DASH complex subunit DAD3; DUO1 and DAM1-interacting protein 3; Outer kinetochore protein DAD3", "protein_names_refseq": "Dad3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR233W-A)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "12408861;14562095;14562106;15640796;15664196;16415853;16715078;16777964;17460120;17643123;18079178;19779198;20190278;23749301;24374639;24930965;25236177;32597660;33491328;36701236;7813418", "class_list": "", "function": "Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerization to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (PubMed:15664196, PubMed:16415853, PubMed:16777964, PubMed:17460120, PubMed:17643123). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (PubMed:15664196, PubMed:25236177). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle (PubMed:12408861). During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex (PubMed:25236177). When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation (PubMed:15640796, PubMed:15664196, PubMed:25236177). Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids (PubMed:16415853, PubMed:16777964). Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components (PubMed:12408861). Links the microtubule cytoskeleton to chromosomes during interphase (PubMed:36701236). Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase (PubMed:18079178)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQM9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005874 microtubule;GO:0072686 mitotic spindle;GO:0042729 DASH complex", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0031116 positive regulation of microtubule polymerization;GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore;GO:1990758 mitotic sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P69850-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P69851-1", "uniprot_id": "DAD4_YEAST", "mass": 8155.0, "length": 72, "protein_name": "DASH complex subunit DAD4", "gene_name": "DAD4", "organism": "Yeast", "refseq_name": "Dad4p", "refseq_ac": "NP_710144", "gene_names_uniprotkb": "DAD4; HSK2", "gene_names_refseq": "DAD4; HSK2", "protein_names_uniprotkb": "DASH complex subunit DAD4; DUO1 and DAM1-interacting protein 4; Helper of ASK1 protein 2; Outer kinetochore protein DAD4", "protein_names_refseq": "Dad4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR320C-A)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12408861;14562095;14562106;15632076;15640796;15664196;16415853;16715078;16777964;17460120;17643123;18079178;22814378;24374639;24930965;25236177;36651597;36701236;9169867", "class_list": "", "function": "Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerization to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (PubMed:15664196, PubMed:16415853, PubMed:16777964, PubMed:17460120, PubMed:17643123). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (PubMed:15664196, PubMed:25236177). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle (PubMed:12408861). During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex (PubMed:25236177). When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation (PubMed:15640796, PubMed:15664196, PubMed:25236177). Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids (PubMed:16415853, PubMed:16777964). Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components (PubMed:12408861). Links the microtubule cytoskeleton to chromosomes during interphase (PubMed:36701236). Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase (PubMed:18079178)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSV2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005874 microtubule;GO:0072686 mitotic spindle;GO:0042729 DASH complex", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0031116 positive regulation of microtubule polymerization;GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore;GO:1990758 mitotic sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P69851-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P69852-1", "uniprot_id": "HSK3_YEAST", "mass": 8088.0, "length": 69, "protein_name": "DASH complex subunit HSK3", "gene_name": "HSK3", "organism": "Yeast", "refseq_name": "Hsk3p", "refseq_ac": "NP_690844", "gene_names_uniprotkb": "HSK3", "gene_names_refseq": "HSK3", "protein_names_uniprotkb": "DASH complex subunit HSK3; Helper of ASK1 protein 3; Outer kinetochore protein HSK3", "protein_names_refseq": "Hsk3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL138C-A)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12408861;15632076;15640796;15664196;16415853;16715078;16777964;17460120;17643123;18079178;22814378;24374639;25236177;36701236;8196765", "class_list": "", "function": "Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerization to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase (PubMed:15664196, PubMed:16415853, PubMed:16777964, PubMed:17460120, PubMed:17643123). Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules (PubMed:15664196, PubMed:16415853, PubMed:16777964, PubMed:17460120). Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle (PubMed:12408861). During spindle-kinetochore attachment, kinetochores first attach to the lateral surface of spindle microtubules, which supports the congression of chromosomes toward the middle of the dividing cell; they then slide along towards the spindle pole, a process independent of the DASH complex but requiring the NDC80 complex (PubMed:25236177). When the end of a disassembling microtubule reaches the laterally attached kinetochore, the DASH complex together with the NDC80 complex and STU2 convert lateral attachment to end-on capture to produce a structure that can track with microtubule shortening and sustain attachment when tension is applied across sister kinetochores upon their biorientation (PubMed:15640796, PubMed:15664196, PubMed:25236177). Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached DASH complex to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids (PubMed:16415853, PubMed:16777964). Incorrect microtubule attachments are corrected by releasing microubules from the kinetochore through phosphorylation by IPL1 of kinetochore components (PubMed:12408861). Links the microtubule cytoskeleton to chromosomes during interphase (PubMed:36701236). Also contributes to the poleward transport of kinetochores on microtubules following centromeric DNA replication in S-phase (PubMed:18079178)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX58", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005874 microtubule;GO:0072686 mitotic spindle;GO:0042729 DASH complex", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0031116 positive regulation of microtubule polymerization;GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore;GO:1990758 mitotic sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P69852-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P80428-1", "uniprot_id": "ARP4_YEAST", "mass": 54832.0, "length": 489, "protein_name": "Actin-related protein 4", "gene_name": "ARP4", "organism": "Yeast", "refseq_name": "Arp4p", "refseq_ac": "NP_012454", "gene_names_uniprotkb": "ARP4; ACT3; J1012", "gene_names_refseq": "ACT3; ARP4", "protein_names_uniprotkb": "Actin-related protein 4; Actin-like protein 4; Actin-like protein ARP4", "protein_names_refseq": "Arp4p", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 76 (Disease Ontology:DOID:0112212); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (sce:YJL081C)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10911987;10952318;11937627;12353039;12887900;14562106;14622406;14645854;14690591;14690608;15045029;15610740;17330950;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;23749301;24374639;32597660;33481703;33491328;7483841;8058791;8573785;8641269;9290209", "class_list": "", "function": "Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. ARP4 recognizes H2AS128ph (gamma-H2A) and is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes. Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates. The INO80 complex is involved in DNA repair by associating to gamma-H2A as a response to DNA damage., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWA2", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0031011 Ino80 complex;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000785 chromatin", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P80428-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81449-1", "uniprot_id": "ATPJ_YEAST", "mass": 10876.0, "length": 96, "protein_name": "ATP synthase subunit e, mitochondrial", "gene_name": "TIM11", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit e", "refseq_ac": "NP_010609", "gene_names_uniprotkb": "TIM11; ATP21; YDR322BC", "gene_names_refseq": "ATP21; TIM11", "protein_names_uniprotkb": "ATP synthase subunit e, mitochondrial; ATPase subunit e; Translocase of the inner membrane protein 11", "protein_names_refseq": "F1F0 ATP synthase subunit e", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR322C-A)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;17322287;24374639;33481703;9169867;9271204;9857174", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSV5", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042407 cristae formation;GO:0015986 proton motive force-driven ATP synthesis;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81449-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P81450-1", "uniprot_id": "ATP18_YEAST", "mass": 6688.0, "length": 59, "protein_name": "ATP synthase subunit J, mitochondrial", "gene_name": "ATP18", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit i", "refseq_ac": "NP_013629", "gene_names_uniprotkb": "ATP18; YML081BC", "gene_names_refseq": "ATP18", "protein_names_uniprotkb": "ATP synthase subunit J, mitochondrial; ATPase synthase I subunit", "protein_names_refseq": "F1F0 ATP synthase subunit i", "tax_id": 559292, "disease": "", "pathway": " (sce:YML081C-A)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;16823961;17322287;24374639;9169872;9867807;9867878", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0K1", "ec_number_list": "", "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81450-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P89114-1", "uniprot_id": "SAE3_YEAST", "mass": 10827.0, "length": 91, "protein_name": "Pachytene arrest protein SAE3", "gene_name": "SAE3", "organism": "Yeast", "refseq_name": "Sae3p", "refseq_ac": "NP_011947", "gene_names_uniprotkb": "SAE3", "gene_names_refseq": "SAE3; YHR079C-B", "protein_names_uniprotkb": "Pachytene arrest protein SAE3; Sporulation in the absence of SPO11 protein 3", "protein_names_refseq": "Sae3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR079C-A)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15238514;15579681;15620352;16341884;21126336;24374639;8091229;9215889", "class_list": "", "function": "Involved in meiotic DNA-break repair. Required for the recruitment of DCM1 to meiosis recombination hot spots., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL30", "ec_number_list": "", "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0000707 meiotic DNA recombinase assembly;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P89114-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00055-1", "uniprot_id": "GPD1_YEAST", "mass": 42869.0, "length": 391, "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)] 1", "gene_name": "GPD1", "organism": "Yeast", "refseq_name": "glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1", "refseq_ac": "NP_010262", "gene_names_uniprotkb": "GPD1; D2830; DAR1; HOR1; OSG1", "gene_names_refseq": "DAR1; GPD1; HOR1; OSG1; OSR5", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase [NAD(+)] 1; 1.1.1.8", "protein_names_refseq": "glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1", "tax_id": 559292, "disease": "Brugada syndrome 2 (Disease Ontology:DOID:0110219)", "pathway": " (sce:YDL022W); (R-SCE-1483166)", "pathway_count": 2, "publication_count": 31, "publication_id_list": "11875433;14562095;14562106;15210723;15665377;15773992;1676389;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20026609;20702584;21126336;21177495;22218487;23149688;23749301;24374639;32597660;33229814;33481703;33491328;7934860;7961476;8196651;8935650;9169867", "class_list": "", "function": "Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as an osmoregulator that prevents loss of water and turgor of the cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A5YWB0;D6VRW8;Q6J5J2;Q6J5J5", "ec_number_list": "1.1.1.8", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051287 NAD binding;GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity;GO:0141152 glycerol-3-phosphate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006072 glycerol-3-phosphate metabolic process;GO:0016558 protein import into peroxisome matrix;GO:0046168 glycerol-3-phosphate catabolic process;GO:0006973 intracellular accumulation of glycerol", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q00055-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00246-1", "uniprot_id": "RHO4_YEAST", "mass": 32186.0, "length": 291, "protein_name": "GTP-binding protein RHO4", "gene_name": "RHO4", "organism": "Yeast", "refseq_name": "Rho family GTPase RHO4", "refseq_ac": "NP_012981", "gene_names_uniprotkb": "RHO4", "gene_names_refseq": "RHO4", "protein_names_uniprotkb": "GTP-binding protein RHO4; 3.6.5.2", "protein_names_refseq": "Rho family GTPase RHO4", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR055W); (R-SCE-198203); (R-SCE-392451); (R-SCE-416482); (R-SCE-5625740); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013106); (R-SCE-9035034); (R-SCE-9696264); (R-SCE-9696270); (R-SCE-9696273)", "pathway_count": 12, "publication_count": 16, "publication_id_list": "1408836;1448099;1587484;17322287;18407956;19779198;20702584;21126336;23749301;24374639;30516470;33481703;33491328;8196765;8256523;8754839", "class_list": "", "function": "Plays an important role in cell growth. Required to keep the uninucleated state. May be involved in the organization of the cytoskeleton which affects microtubule functions. Most likely RHO3 and RHO4 of S.cerevisiae regulate partially overlapping but different pathways., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB6;P30618", "ec_number_list": "3.6.5.2;3.6.5.3;3.6.5.-;3.6.5.4;2.7.11.13;3.1.3.48;3.6.5.5;1.3.1.70;3.1.4.4;3.4.11.-;3.4.-.-;3.6.4.-;1.2.1.3;1.2.1.64;2.7.11.1", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000131 incipient cellular bud site", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0030011 maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q00246-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00362-1", "uniprot_id": "2ABA_YEAST", "mass": 59662.0, "length": 526, "protein_name": "Protein phosphatase PP2A regulatory subunit B", "gene_name": "CDC55", "organism": "Yeast", "refseq_name": "protein phosphatase 2A regulatory subunit CDC55", "refseq_ac": "NP_011325", "gene_names_uniprotkb": "CDC55; G1345", "gene_names_refseq": "CDC55; TMR4", "protein_names_uniprotkb": "Protein phosphatase PP2A regulatory subunit B; Cell division control protein 55; PR55", "protein_names_refseq": "protein phosphatase 2A regulatory subunit CDC55", "tax_id": 559292, "disease": "spinocerebellar ataxia 12 (Disease Ontology:DOID:0050962); Alzheimer's disease (Disease Ontology:DOID:10652); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); breast cancer (Disease Ontology:DOID:1612); systemic lupus erythematosus (Disease Ontology:DOID:9074); brain disease (Disease Ontology:DOID:936)", "pathway": " (sce:YGL190C); (R-SCE-69273); (R-SCE-975957)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "14562106;16227198;1656238;18407956;19779198;20702584;21126336;23749301;24374639;24909858;30927017;32597660;33481703;33491328;9046087;9169869", "class_list": "", "function": "Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTW4", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint;GO:1900182 positive regulation of protein localization to nucleus;GO:0001100 negative regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q00362-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00381-1", "uniprot_id": "AP2S_YEAST", "mass": 17373.0, "length": 147, "protein_name": "AP-2 complex subunit sigma", "gene_name": "APS2", "organism": "Yeast", "refseq_name": "Aps2p", "refseq_ac": "NP_012592", "gene_names_uniprotkb": "APS2; J1720; YAP17", "gene_names_refseq": "APS2; YAP17", "protein_names_uniprotkb": "AP-2 complex subunit sigma; Adaptin small chain; Clathrin assembly protein 2 sigma small chain; Clathrin coat assembly protein AP17; Clathrin coat-associated protein AP17; Plasma membrane adaptor AP-2 17 kDa protein; Sigma2-adaptin", "protein_names_refseq": "Aps2p", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); familial hypocalciuric hypercalcemia 3 (Disease Ontology:DOID:0060702)", "pathway": " (sce:YJR058C); (R-SCE-437239); (R-SCE-8856825); (R-SCE-8856828); (R-SCE-8866427); (R-SCE-8964038)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10564262;14562106;17322287;2040623;24374639;8641269;8840504", "class_list": "", "function": "Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWM9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0030136 clathrin-coated vesicle;GO:0030122 AP-2 adaptor complex;GO:0005628 prospore membrane;GO:0005935 cellular bud neck", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q00381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00539-1", "uniprot_id": "NAM8_YEAST", "mass": 56972.0, "length": 523, "protein_name": "Protein NAM8", "gene_name": "NAM8", "organism": "Yeast", "refseq_name": "Nam8p", "refseq_ac": "NP_011954", "gene_names_uniprotkb": "NAM8; MRE2; MUD15", "gene_names_refseq": "MRE2; MUD15; NAM8", "protein_names_uniprotkb": "Protein NAM8; Nuclear accommodation of mitochondria protein 8; U1 snRNP component NAM8", "protein_names_refseq": "Nam8p", "tax_id": 559292, "disease": "amyotrophic lateral sclerosis type 26 (Disease Ontology:DOID:0081380)", "pathway": " (sce:YHR086W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10072385;10983980;14562106;1603056;18407956;21126336;21208980;21788335;23749301;24374639;2651895;29051543;29794219;29995849;31485080;33481703;33491328;34349264;7625279;8091229;9112441;9630245", "class_list": "", "function": "Component of the U1 small nuclear ribonucleoprotein complex (U1 snRNP) involved in the initiation of meiotic recombination (PubMed:1603056, PubMed:7625279). Involved in the formation of DSBs at recombination hot-spots through meiosis-specific splicing of REC107 pre-mRNA (PubMed:21788335, PubMed:7625279, PubMed:9112441). Collaborates with MER1 to promote splicing of essential meiotic mRNAs REC10, AMA1, MER3, HFM1, SPO22 and PCH2 (PubMed:10983980, PubMed:21208980, PubMed:21788335). NAM8 interacts with the pre-mRNA downstream of the 5' splice site, in a region of non-conserved sequence and is required for efficient splicing of uncapped RNA precursor (PubMed:10072385)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL37", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000243 commitment complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0000398 mRNA splicing, via spliceosome;GO:0006376 mRNA splice site recognition;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q00539-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00578-1", "uniprot_id": "RAD25_YEAST", "mass": 95341.0, "length": 843, "protein_name": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2", "gene_name": "SSL2", "organism": "Yeast", "refseq_name": "TFIIH/NER complex ATPase/helicase subunit SSL2", "refseq_ac": "NP_012123", "gene_names_uniprotkb": "SSL2; LOM3; RAD25; UVS112", "gene_names_refseq": "LOM3; RAD25; SSL2", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2; 5.6.2.4; DNA 3'-5' helicase/translocase XPB/SSL2; DNA repair helicase RAD25/SSL2; RNA polymerase II transcription factor B subunit SSL2; Suppressor of stem-loop mutation 2; TFB subunit SSL2; TFIIH subunit XPB/SSL2", "protein_names_refseq": "TFIIH/NER complex ATPase/helicase subunit SSL2", "tax_id": 559292, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group B (Disease Ontology:DOID:0110850); trichothiodystrophy (Disease Ontology:DOID:0111866); photosensitive trichothiodystrophy 2 (Disease Ontology:DOID:0111869); Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); Down syndrome (Disease Ontology:DOID:14250); Cockayne syndrome (Disease Ontology:DOID:2962); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YIL143C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 14, "publication_count": 21, "publication_id_list": "1318786;1333609;14500720;14562106;17322287;17330950;22411836;23749301;24374639;25775526;26483468;27610567;33481703;33491328;7693549;7813015;7961739;8202161;8269516;8631896;9169870", "class_list": "", "function": "ATP-dependent DNA translocase (PubMed:25775526). Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II (PubMed:14500720, PubMed:7693549, PubMed:7813015, PubMed:7961739, PubMed:8202161, PubMed:8269516, PubMed:8631896). May have 3'-5' helicase activity alone, the TFIIH core however has no 3'-5' helicase activity (PubMed:25775526). Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA (PubMed:7693549, PubMed:7813015, PubMed:8202161, PubMed:8269516, PubMed:8631896). In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape. XPB/SSL2 acts as a double-stranded DNA translocase, promoting DNA opening by tracking in a 5'-3' dirction along the nontemplate promoter strand, rotating and inserting DNA into the Pol II active site cleft, leading to DNA unwinding (PubMed:25775526). A dsDNA-stimulated ATPase, dATP and ATP are equally good substrates (PubMed:25775526). May also use this translocase mechanism during DNA repair rather than physically wedging open damaged DNA (PubMed:25775526)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVE4", "ec_number_list": "2.7.7.6;2.7.11.23;3.6.4.13;5.6.2.3;3.1.-.-;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;2.7.7.7;3.1.11.-;2.7.11.22;3.6.4.12;3.6.4.6;5.6.2.5;2.3.2.27;2.1.1.56;3.6.1.-;3.4.24.-;3.6.5.-;2.3.1.48;3.4.19.12;5.2.1.8;2.7.7.50;3.1.3.16;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005675 transcription factor TFIIH holo complex;GO:0000112 nucleotide-excision repair factor 3 complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair;GO:0001111 RNA polymerase II promoter clearance", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q00578-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00711-1", "uniprot_id": "SDHA_YEAST", "mass": 70229.0, "length": 640, "protein_name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "gene_name": "SDH1", "organism": "Yeast", "refseq_name": "succinate dehydrogenase flavoprotein subunit SDH1", "refseq_ac": "NP_012774", "gene_names_uniprotkb": "SDH1; SDHA; YKL602", "gene_names_refseq": "SDH1", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; 1.3.5.1; FP; Flavoprotein subunit of complex II", "protein_names_refseq": "succinate dehydrogenase flavoprotein subunit SDH1", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pheochromocytoma (Disease Ontology:DOID:0050771); paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 5 (Disease Ontology:DOID:0061220); dilated cardiomyopathy 1GG (Disease Ontology:DOID:0110435); leukodystrophy (Disease Ontology:DOID:10579); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); Leigh disease (Disease Ontology:DOID:3652); pituitary adenoma (Disease Ontology:DOID:3829); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)", "pathway": " (sce:YKL148C); (R-SCE-71403); (R-SCE-9854311)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11502169;11803020;14562106;14672929;1511876;1518827;1577780;19628817;24374639;33491328;8026509;8091859;8120006;8196765", "class_list": "", "function": "Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX49", "ec_number_list": "1.3.5.1", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0008177 succinate dehydrogenase (quinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q00711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00873-1", "uniprot_id": "CYT2_YEAST", "mass": 26076.0, "length": 224, "protein_name": "Holocytochrome-c1 synthase", "gene_name": "CYT2", "organism": "Yeast", "refseq_name": "cytochrome c1 heme lyase CYT2", "refseq_ac": "NP_012836", "gene_names_uniprotkb": "CYT2", "gene_names_refseq": "CYT2", "protein_names_uniprotkb": "Holocytochrome-c1 synthase; 4.4.1.17; CC1HL; Cytochrome c1 heme lyase", "protein_names_refseq": "cytochrome c1 heme lyase CYT2", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL087C); (R-SCE-611105)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1499554;23749301;24374639;33491328;8196765", "class_list": "", "function": "Lyase that catalyzes the covalent linking of the heme group to the cytochrome C1 apoprotein to produce the mature functional cytochrome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXK1", "ec_number_list": "4.4.1.17", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004408 holocytochrome-c synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0018063 cytochrome c-heme linkage", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q00873-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q00947-1", "uniprot_id": "STP1_YEAST", "mass": 58088.0, "length": 519, "protein_name": "Transcription factor STP1", "gene_name": "STP1", "organism": "Yeast", "refseq_name": "Stp1p", "refseq_ac": "NP_010751", "gene_names_uniprotkb": "STP1; BAP1; D8035.7; SSY2", "gene_names_refseq": "BAP1; SSY2; STP1", "protein_names_uniprotkb": "Transcription factor STP1", "protein_names_refseq": "Stp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR463W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10648791;11212916;12502738;12748633;12775844;14562095;14562106;15126393;15197729;15314160;15509782;1588961;16400180;16735580;16778074;16977312;17085444;17563356;17603098;1803818;18407956;19795423;19823750;23749301;24374639;3072476;33481703;33491328;9065387;9169867;9171100", "class_list": "", "function": "Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases AGP1, BAP2, BAP3 and GNP1. Binding to promoters is facilitated by DAL81. Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes. May be involved in pre-tRNA splicing., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT88", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008033 tRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q00947-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01080-1", "uniprot_id": "RPA49_YEAST", "mass": 46651.0, "length": 415, "protein_name": "DNA-directed RNA polymerase I subunit RPA49", "gene_name": "RPA49", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase I subunit RPA49", "refseq_ac": "NP_014151", "gene_names_uniprotkb": "RPA49; N0880; RRN13", "gene_names_refseq": "RPA49", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA49; A49; DNA-directed RNA polymerase I 49 kDa polypeptide", "protein_names_refseq": "DNA-directed RNA polymerase I subunit RPA49", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL248C); (R-SCE-73762); (R-SCE-73772)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "11717393;12145213;12407181;1409638;14562095;17322287;18160037;18407956;19779198;19795423;19823750;20797630;23749301;24153182;24153184;24374639;32597660;33481703;33491328;9169873;9234673", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I. Subunit RPA49 can bind both single-stranded and double-stranded DNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0U5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042254 ribosome biogenesis;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q01080-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01217-1", "uniprot_id": "ARG56_YEAST", "mass": 94869.0, "length": 863, "protein_name": "Protein ARG5,6, mitochondrial", "gene_name": "ARG5,6", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "ARG5,6", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein ARG5,6, mitochondrial; AGK; N-acetyl-L-glutamate 5-phosphotransferase; N-acetyl-glutamate semialdehyde dehydrogenase; NAG kinase; NAGSA dehydrogenase", "protein_names_refseq": "", "tax_id": 559292, "disease": "N-acetylglutamate synthase deficiency (Disease Ontology:DOID:0112258); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YER069W); (R-SCE-70635)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14562106;1649049;17330950;17563356;18407956;1851947;19795423;19823750;20702584;24374639;33481703;33491328;9169868", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLX4", "ec_number_list": "1.2.1.38;2.7.2.8", "go_molecular_function": "GO:0005524 ATP binding;GO:0051287 NAD binding;GO:0070401 NADP+ binding;GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity;GO:0003991 acetylglutamate kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006526 L-arginine biosynthetic process;GO:0006592 ornithine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q01217-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01476-1", "uniprot_id": "UBP2_YEAST", "mass": 146355.0, "length": 1272, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 2", "gene_name": "UBP2", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP2", "refseq_ac": "NP_014767", "gene_names_uniprotkb": "UBP2; O3281; YOR3281C", "gene_names_refseq": "UBP2", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 2; 3.4.19.12; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2", "protein_names_refseq": "ubiquitin-specific protease UBP2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR124C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "1429680;14562106;15933713;17330950;17563356;18407956;19779198;19795423;19823750;19920177;21126336;21177495;23317502;23749301;24374639;32597660;33481703;33491328;8904341;9169874;9200815", "class_list": "", "function": "Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety in natural or engineered linear fusion proteins, irrespective of their size or the presence of an N-terminal extension to ubiquitin (PubMed:15933713). Hydrolyzes polyubiquitinated 'Lys-63' polyubiquitin chains in RPO21, producing mono-ubiquitinated RNA polymerase II (PubMed:19920177). Removes ubiquitin chains that initiate proteolysis of FZO1 and inhibit mitochondrial fusion (PubMed:23317502)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2I2;Q99357", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0010992 ubiquitin recycling;GO:0016579 protein deubiquitination;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q01476-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01532-1", "uniprot_id": "BLH1_YEAST", "mass": 55483.0, "length": 483, "protein_name": "Cysteine proteinase 1, mitochondrial", "gene_name": "LAP3", "organism": "Yeast", "refseq_name": "bleomycin hydrolase", "refseq_ac": "NP_014160", "gene_names_uniprotkb": "LAP3; BLH1; GAL6; N1118; YCP1", "gene_names_refseq": "BLH1; GAL6; LAP3; YCP1", "protein_names_uniprotkb": "Cysteine proteinase 1, mitochondrial; 3.4.22.40; BLM hydrolase; Bleomycin hydrolase; HTLase; Hcy-thiolactonase; Homocysteine-thiolactonase; Leucine aminopeptidase 3; Y3", "protein_names_refseq": "bleomycin hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL239W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "12555812;1400467;14562095;14562106;14576278;16769724;17101987;18407956;1882548;19779198;24374639;33491328;7638617;8063738;8424954;8463237;8896273;9169873;9374524;9546396;9584198", "class_list": "", "function": "The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0V4", "ec_number_list": "3.4.11.-;3.4.22.40", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004177 aminopeptidase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0009636 response to toxic substance;GO:0046677 response to antibiotic;GO:0043418 homocysteine catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q01532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01574-1", "uniprot_id": "ACS1_YEAST", "mass": 79141.0, "length": 713, "protein_name": "Acetyl-coenzyme A synthetase 1", "gene_name": "ACS1", "organism": "Yeast", "refseq_name": "acetate--CoA ligase 1", "refseq_ac": "NP_009347", "gene_names_uniprotkb": "ACS1; FUN44", "gene_names_refseq": "ACS1; FUN44", "protein_names_uniprotkb": "Acetyl-coenzyme A synthetase 1; 6.2.1.1; Acetate--CoA ligase 1; Acyl-activating enzyme 1", "protein_names_refseq": "acetate--CoA ligase 1", "tax_id": 559292, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); morbid obesity (Disease Ontology:DOID:11981); alcohol use disorder (Disease Ontology:DOID:1574); lymphangioleiomyomatosis (Disease Ontology:DOID:3319)", "pathway": " (sce:YAL054C); (R-SCE-71384)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11914276;1363452;14562095;14562106;14576278;14769018;16857587;17322287;24374639;33491328;7642141;7731988;8910545;9252575", "class_list": "", "function": "Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. 'Aerobic' isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPG4;Q66RJ0", "ec_number_list": "6.2.1.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0016208 AMP binding;GO:0003987 acetate-CoA ligase activity;GO:0016880 acid-ammonia (or amide) ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006085 acetyl-CoA biosynthetic process;GO:0019427 acetyl-CoA biosynthetic process from acetate;GO:0019654 acetate fermentation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q01574-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01589-1", "uniprot_id": "SED1_YEAST", "mass": 34431.0, "length": 338, "protein_name": "Cell wall protein SED1", "gene_name": "SED1", "organism": "Yeast", "refseq_name": "Sed1p", "refseq_ac": "NP_010362", "gene_names_uniprotkb": "SED1; D4431", "gene_names_refseq": "SED1", "protein_names_uniprotkb": "Cell wall protein SED1; Glycoprotein GP260", "protein_names_refseq": "Sed1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR077W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12406735;1327759;14562106;15093776;15165243;16086015;17322287;24374639;7483840;8980634;9023939;9169867;9642191", "class_list": "", "function": "Component of the cell wall. Major cell wall protein in stationary phase cells. Required to stabilize the cell wall in the absence of multiple GPI-anchored mannoproteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VS63;Q6Q5U8;Q8J057;Q8J270;Q8J271;Q8J272;Q8J273;Q8J274;Q8J275", "ec_number_list": "", "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0005739 mitochondrion;GO:0071944 cell periphery;GO:0005840 ribosome;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q01589-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01649-1", "uniprot_id": "CIK1_YEAST", "mass": 69070.0, "length": 594, "protein_name": "Spindle pole body-associated protein CIK1", "gene_name": "CIK1", "organism": "Yeast", "refseq_name": "Cik1p", "refseq_ac": "NP_013925", "gene_names_uniprotkb": "CIK1; YM9646.11", "gene_names_refseq": "CIK1", "protein_names_uniprotkb": "Spindle pole body-associated protein CIK1; Chromosome instability and karyogamy protein 1", "protein_names_refseq": "Cik1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR198W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10087265;11729143;14562106;1644287;17382884;19779198;24374639;25313961;33481703;33491328;8106549;9169872", "class_list": "", "function": "Together with the minus end-directed microtubule motor KAR3, involved in spindle midzone assembly, karyogamy (nuclear fusion) during mating, and with an essential function in meiosis I (PubMed:17382884, PubMed:25313961, PubMed:8106549). To contribute to spindle midzone assembly during mitotic metaphase, the KAR3-CIK1 motor cross-links anti-parallel microtubules to align them on the spindle axis; as the motor travels polewards splayed microtubules are pulled into alignment (PubMed:25313961). During the karyogamy (nuclear fusion) step of mating, KAR3-CIK1 cross-links antiparallel cytoplasmic microtubules emanating from the spindle pole bodies of mating partners; the motor activity of KAR3 creates the force that pulls the nuclei together by sliding cross-linked microtubules past one another (PubMed:10087265, PubMed:8106549). KAR3-CIK1 promotes microtubule shortening predominantly from the microtubule plus-end (PubMed:17382884). Required for interhomolog recombination, synapsis of homologous chromosomes and establishment of a meiosis I spindle (PubMed:11729143)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W023", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0008093 cytoskeletal anchor activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0005871 kinesin complex;GO:0005881 cytoplasmic microtubule;GO:0005816 spindle pole body", "go_biological_process": "GO:0060236 regulation of mitotic spindle organization;GO:0051256 mitotic spindle midzone assembly;GO:0051321 meiotic cell cycle;GO:0000742 karyogamy involved in conjugation with cellular fusion;GO:0000743 nuclear migration involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q01649-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01662-1", "uniprot_id": "MAP1_YEAST", "mass": 43373.0, "length": 387, "protein_name": "Methionine aminopeptidase 1", "gene_name": "MAP1", "organism": "Yeast", "refseq_name": "methionine aminopeptidase MAP1", "refseq_ac": "NP_013345", "gene_names_uniprotkb": "MAP1; L9672.12", "gene_names_refseq": "MAP1", "protein_names_uniprotkb": "Methionine aminopeptidase 1; 3.4.11.18; MAP 1; MetAP 1; Peptidase M 1", "protein_names_refseq": "methionine aminopeptidase MAP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR244C); (R-SCE-2514859)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10075912;11811952;11968008;12874831;14562106;1569059;21126336;22814378;24374639;32597660;33481703;33491328;35584675;7862096;9169871;9177176;9367524;9865965", "class_list": "", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays the major role in N-terminal methionine removal. Less efficient when the second residue is Val., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYP2", "ec_number_list": "3.4.11.18", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q01662-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01722-1", "uniprot_id": "GCR2_YEAST", "mass": 58062.0, "length": 534, "protein_name": "Glycolytic genes transcriptional activator GCR2", "gene_name": "GCR2", "organism": "Yeast", "refseq_name": "Gcr2p", "refseq_ac": "NP_014200", "gene_names_uniprotkb": "GCR2; N1374", "gene_names_refseq": "GCR2", "protein_names_uniprotkb": "Glycolytic genes transcriptional activator GCR2", "protein_names_refseq": "Gcr2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL199C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11333224;1508187;18407956;19779198;19823750;23749301;24374639;32597660;33491328;7725799;9169873;9335588", "class_list": "", "function": "Transcriptional activator required for the expression of glycolytic genes. Enhances the CT box-dependent transcriptional activation of a RAP1-GCR1 complex. Required for GCR1 phosphorylation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Y9", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006110 regulation of glycolytic process;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060196 positive regulation of antisense RNA transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q01722-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01855-1", "uniprot_id": "RS15_YEAST", "mass": 16002.0, "length": 142, "protein_name": "Small ribosomal subunit protein uS19", "gene_name": "RPS15", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS19 RPS15", "refseq_ac": "NP_014602", "gene_names_uniprotkb": "RPS15; RPS21", "gene_names_refseq": "RPS15; RPS21", "protein_names_uniprotkb": "Small ribosomal subunit protein uS19; 40S ribosomal protein S15; RIG protein; RP52; S21; YS21", "protein_names_refseq": "40S ribosomal protein uS19 RPS15", "tax_id": 559292, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040); insulinoma (Disease Ontology:DOID:3892)", "pathway": " (sce:YOL040C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 20, "publication_id_list": "10601260;11701127;14976550;15167894;1644188;17287358;17322287;18407956;21109664;21126336;22096102;22106047;22814378;23749301;24374639;24524803;33481703;33491328;9169874;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS19 is involved in the nuclear export of the small ribosomal subunit precursor. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm (PubMed:15167894)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W226", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q01855-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01896-1", "uniprot_id": "ATN2_YEAST", "mass": 120317.0, "length": 1091, "protein_name": "Sodium/potassium exporting P-type ATPase 2", "gene_name": "ENA2", "organism": "Yeast", "refseq_name": "Na(+)-exporting P-type ATPase ENA2", "refseq_ac": "NP_010324", "gene_names_uniprotkb": "ENA2; PMR2B", "gene_names_refseq": "ENA2", "protein_names_uniprotkb": "Sodium/potassium exporting P-type ATPase 2; 7.2.2.3", "protein_names_refseq": "Na(+)-exporting P-type ATPase ENA2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR039C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;16847258;22329368;23749301;24374639;32597660;7664728;8437581;9169867", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the export of sodium and potassium from the cell (PubMed:7664728, PubMed:8437581). May export potassium less efficiently (PubMed:22329368). May transport other cations such as lithium (PubMed:7664728, PubMed:8437581). Sodium/potassium efflux ATPases are involved in salt tolerance and maintaining the membrane potential across the plasma membrane in high salinity (Na+) or alkaline (K+) environments (PubMed:22329368, PubMed:7664728, PubMed:8437581)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS27", "ec_number_list": "7.2.2.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008554 P-type sodium transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015662 P-type ion transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0034220 monoatomic ion transmembrane transport;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q01896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01919-1", "uniprot_id": "KIN4_YEAST", "mass": 90088.0, "length": 800, "protein_name": "Serine/threonine-protein kinase KIN4", "gene_name": "KIN4", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase KIN4", "refseq_ac": "NP_014876", "gene_names_uniprotkb": "KIN4; KIN31; KIN3; O5220", "gene_names_refseq": "KIN31; KIN3; KIN4", "protein_names_uniprotkb": "Serine/threonine-protein kinase KIN4; 2.7.11.1", "protein_names_refseq": "putative serine/threonine protein kinase KIN4", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR233W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20855503;21041444;21177495;22570619;23749301;24374639;32597660;33481703;33491328;8465601;8972580;9169874", "class_list": "", "function": "This protein is probably a serine/threonine protein kinase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 48, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2T7", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005938 cell cortex;GO:0005816 spindle pole body;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000011 vacuole inheritance;GO:0031578 mitotic spindle orientation checkpoint signaling;GO:0045033 peroxisome inheritance;GO:0071988 protein localization to spindle pole body", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q01919-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q01926-1", "uniprot_id": "MRS2_YEAST", "mass": 54203.0, "length": 470, "protein_name": "Magnesium transporter MRS2, mitochondrial", "gene_name": "MRS2", "organism": "Yeast", "refseq_name": "Mrs2p", "refseq_ac": "NP_014979", "gene_names_uniprotkb": "MRS2", "gene_names_refseq": "MRS2", "protein_names_uniprotkb": "Magnesium transporter MRS2, mitochondrial; RNA-splicing protein MRS2", "protein_names_refseq": "Mrs2p", "tax_id": 559292, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (sce:YOR334W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11544180;11932259;12628916;14562095;14562106;1551905;17827224;20653776;23999289;24374639;8252639;8896263;9169874", "class_list": "", "function": "High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix (PubMed:12628916, PubMed:17827224, PubMed:20653776, PubMed:23999289). Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes (PubMed:11544180)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W329", "ec_number_list": "", "go_molecular_function": "GO:1901612 cardiolipin binding;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045016 mitochondrial magnesium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q01926-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02046-1", "uniprot_id": "MTD1_YEAST", "mass": 36240.0, "length": 320, "protein_name": "Methylenetetrahydrofolate dehydrogenase [NAD(+)]", "gene_name": "MTD1", "organism": "Yeast", "refseq_name": "methylenetetrahydrofolate dehydrogenase (NAD(+))", "refseq_ac": "NP_013006", "gene_names_uniprotkb": "MTD1; YKR400", "gene_names_refseq": "MTD1", "protein_names_uniprotkb": "Methylenetetrahydrofolate dehydrogenase [NAD(+)]; 1.5.1.15", "protein_names_refseq": "methylenetetrahydrofolate dehydrogenase (NAD(+))", "tax_id": 559292, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YKR080W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10933503;14562095;14562106;2223762;24374639;33491328;8196765;8203164;8416923", "class_list": "", "function": "Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXE0", "ec_number_list": "1.5.1.15", "go_molecular_function": "GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0009113 purine nucleobase biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0009396 folic acid-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q02046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02100-1", "uniprot_id": "SKO1_YEAST", "mass": 70192.0, "length": 647, "protein_name": "CRE-binding bZIP protein SKO1", "gene_name": "SKO1", "organism": "Yeast", "refseq_name": "Sko1p", "refseq_ac": "NP_014232", "gene_names_uniprotkb": "SKO1; ACR1; N1702", "gene_names_refseq": "ACR1; SKO1", "protein_names_uniprotkb": "CRE-binding bZIP protein SKO1", "protein_names_refseq": "Sko1p", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); meconium aspiration syndrome (Disease Ontology:DOID:11049); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); osteochondrodysplasia (Disease Ontology:DOID:2256); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YNL167C); (R-SCE-3214847); (R-SCE-450341)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "11230135;1437546;1448073;14562106;17563356;18407956;19779198;19795423;19823750;22218487;23749301;24374639;28265048;28270554;30516470;31208443;32597660;33229814;33481703;33491328;8686380;9169873", "class_list": "", "function": "Binds to the CRE motif 5'-TGACGTCA-3' and acts as a repressor of transcription of the SUC2 gene and most probably other genes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6W115", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0051019 mitogen-activated protein kinase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071470 cellular response to osmotic stress", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q02100-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02159-1", "uniprot_id": "UBC7_YEAST", "mass": 18520.0, "length": 165, "protein_name": "Ubiquitin-conjugating enzyme E2 7", "gene_name": "UBC7", "organism": "Yeast", "refseq_name": "E2 ubiquitin-conjugating protein UBC7", "refseq_ac": "NP_013735", "gene_names_uniprotkb": "UBC7; QRI8; YM9711.12", "gene_names_refseq": "DER2; QRI8; UBC7", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 7; 2.3.2.23; E2 ubiquitin-conjugating enzyme 7; Ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-protein ligase", "protein_names_refseq": "E2 ubiquitin-conjugating protein UBC7", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR022W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11146622;11390656;11641273;1327148;14562106;16179953;16873066;17310239;17322287;24374639;8381213;8393731;9048545;9169872;9172777;9388185;9695950", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Involved in resistance to cadmium poisoning., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZJ6", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex;GO:0000837 Doa10p ubiquitin ligase complex", "go_biological_process": "GO:0046686 response to cadmium ion;GO:0006325 chromatin organization;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q02159-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02196-1", "uniprot_id": "KAPS_YEAST", "mass": 23060.0, "length": 202, "protein_name": "Adenylyl-sulfate kinase", "gene_name": "MET14", "organism": "Yeast", "refseq_name": "adenylyl-sulfate kinase", "refseq_ac": "NP_012925", "gene_names_uniprotkb": "MET14", "gene_names_refseq": "MET14", "protein_names_uniprotkb": "Adenylyl-sulfate kinase; 2.7.1.25; APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase", "protein_names_refseq": "adenylyl-sulfate kinase", "tax_id": 559292, "disease": "spondyloepimetaphyseal dysplasia, Pakistani type (Disease Ontology:DOID:0050812)", "pathway": " (sce:YKL001C); (R-SCE-174362)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1441752;14562106;1654509;17322287;24374639;33491328;8196765", "class_list": "", "function": "Catalyzes the synthesis of activated sulfate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXT6", "ec_number_list": "2.7.1.25", "go_molecular_function": "GO:0005524 ATP binding;GO:0004020 adenylylsulfate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009086 methionine biosynthetic process;GO:0000096 sulfur amino acid metabolic process;GO:0019344 cysteine biosynthetic process;GO:0070814 hydrogen sulfide biosynthetic process;GO:0000103 sulfate assimilation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q02196-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02197-1", "uniprot_id": "NAA35_YEAST", "mass": 84302.0, "length": 733, "protein_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "gene_name": "MAK10", "organism": "Yeast", "refseq_name": "Mak10p", "refseq_ac": "NP_010861", "gene_names_uniprotkb": "MAK10; NAA35", "gene_names_refseq": "MAK10; NAA35", "protein_names_uniprotkb": "N-alpha-acetyltransferase 35, NatC auxiliary subunit; Glucose repressible protein MAK10; L-A virus GAG protein N-acetyltransferase subunit MAK10; Maintenance of killer protein 10; N-terminal acetyltransferase C complex subunit MAK10; NatC complex subunit MAK10", "protein_names_refseq": "Mak10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL053C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11274203;1398065;14562095;14562106;24374639;33491328;9169868", "class_list": "", "function": "Component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein. MAK10 has a role in the propagation of L-A and M viruses, perhaps in the viral assembly. It is apparently directly needed for optimum respiration., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLJ7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031417 NatC complex", "go_biological_process": "GO:0016236 macroautophagy;GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q02197-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02206-1", "uniprot_id": "RSC4_YEAST", "mass": 72291.0, "length": 625, "protein_name": "Chromatin structure-remodeling complex subunit RSC4", "gene_name": "RSC4", "organism": "Yeast", "refseq_name": "Rsc4p", "refseq_ac": "NP_012933", "gene_names_uniprotkb": "RSC4; YK107", "gene_names_refseq": "RSC4", "protein_names_uniprotkb": "Chromatin structure-remodeling complex subunit RSC4; RSC complex subunit RSC4; Remodel the structure of chromatin complex subunit 4", "protein_names_refseq": "Rsc4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR008W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10025404;10329629;10619019;12072455;12183366;12697820;1441752;14562095;14562106;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20190278;21126336;23749301;24374639;30516470;32597660;33481703;33491328;8196765;8980231", "class_list": "", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX74;Q6B1F7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0140008 histone H4 reader activity;GO:0140006 histone H3 reader activity", "go_cellular_component": "GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006368 transcription elongation by RNA polymerase II;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q02206-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02207-1", "uniprot_id": "FOX2_YEAST", "mass": 98703.0, "length": 900, "protein_name": "Peroxisomal hydratase-dehydrogenase-epimerase", "gene_name": "FOX2", "organism": "Yeast", "refseq_name": "bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2", "refseq_ac": "NP_012934", "gene_names_uniprotkb": "FOX2; YK108", "gene_names_refseq": "FOX2; POX2", "protein_names_uniprotkb": "Peroxisomal hydratase-dehydrogenase-epimerase; HDE; MFP; Multifunctional beta-oxidation protein", "protein_names_refseq": "bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2", "tax_id": 559292, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); D-bifunctional protein deficiency (Disease Ontology:DOID:0090031); hypertension (Disease Ontology:DOID:10763); Stiff-Person syndrome (Disease Ontology:DOID:13366); lipid metabolism disorder (Disease Ontology:DOID:3146); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YKR009C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1441752;1551874;24374639;8196765", "class_list": "", "function": "Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX75", "ec_number_list": "1.1.1.n12;4.2.1.119", "go_molecular_function": "GO:0004300 enoyl-CoA hydratase activity;GO:0016853 isomerase activity;GO:0080023 (2E)-enoyl-CoA hydratase activity;GO:0003857 (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity;GO:0106386 (3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02260-1", "uniprot_id": "SMD1_YEAST", "mass": 16275.0, "length": 146, "protein_name": "Small nuclear ribonucleoprotein Sm D1", "gene_name": "SMD1", "organism": "Yeast", "refseq_name": "mRNA splicing protein SMD1", "refseq_ac": "NP_011588", "gene_names_uniprotkb": "SMD1", "gene_names_refseq": "SMD1; SPP92", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D1; Sm-D1; snRNP core protein D1", "protein_names_refseq": "mRNA splicing protein SMD1", "tax_id": 559292, "disease": "nephritis (Disease Ontology:DOID:10952); proteinuria (Disease Ontology:DOID:576); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (sce:YGR074W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10369684;10449419;10490028;11027265;11302706;11804584;11884590;14562106;14690591;17322287;24374639;33491328;8430095;9012791;9169869;9528767", "class_list": "", "function": "lays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:8430095). Also binds telomerase RNA and is required for its accumulation (PubMed:10490028)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUK6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q02260-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02457-1", "uniprot_id": "TBF1_YEAST", "mass": 62824.0, "length": 562, "protein_name": "Protein TBF1", "gene_name": "TBF1", "organism": "Yeast", "refseq_name": "Tbf1p", "refseq_ac": "NP_015197", "gene_names_uniprotkb": "TBF1; LPI16C", "gene_names_refseq": "LPI16; TBF1", "protein_names_uniprotkb": "Protein TBF1; TBF-alpha; TTAGGG repeat-binding factor 1", "protein_names_refseq": "Tbf1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL128C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10871401;11258704;12200417;14562106;18407956;22814378;23749301;24374639;33481703;33491328;8423796;8614633;9169875", "class_list": "", "function": "Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. 52 binding sites have been identified, distributed over 15 chromosomes. A member of the general regulatory factors (GRFs) which act as genome partitioners. Acts as a chromatin insulator which are known as STARs (Subtelomeric anti-silencing region). STARs prevent negative or positive transcription influence by extending across chromatin to a promoter., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3N9", "ec_number_list": "", "go_molecular_function": "GO:0043035 chromatin insulator sequence binding;GO:0042803 protein homodimerization activity;GO:0042162 telomeric DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0006338 chromatin remodeling;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0001015 snoRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q02457-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02486-1", "uniprot_id": "ABF2_YEAST", "mass": 21562.0, "length": 183, "protein_name": "ARS-binding factor 2, mitochondrial", "gene_name": "ABF2", "organism": "Yeast", "refseq_name": "DNA-binding protein ABF2", "refseq_ac": "NP_013788", "gene_names_uniprotkb": "ABF2; HIM1; YM9916.11", "gene_names_refseq": "ABF2", "protein_names_uniprotkb": "ARS-binding factor 2, mitochondrial", "protein_names_refseq": "DNA-binding protein ABF2", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); childhood-onset neurodegeneration with brain atrophy (Disease Ontology:DOID:0070474); mitochondrial DNA depletion syndrome 15 (Disease Ontology:DOID:0080337); syndromic microphthalmia 13 (Disease Ontology:DOID:0111811); hydrocephalus (Disease Ontology:DOID:10908); sciatic neuropathy (Disease Ontology:DOID:11446); Kawasaki disease (Disease Ontology:DOID:13378); obstructive jaundice (Disease Ontology:DOID:13603); alcohol use disorder (Disease Ontology:DOID:1574); atherosclerosis (Disease Ontology:DOID:1936); colon adenocarcinoma (Disease Ontology:DOID:234); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); periodontitis (Disease Ontology:DOID:824)", "pathway": " (sce:YMR072W); (R-SCE-140342); (R-SCE-163282); (R-SCE-9837999)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "14562106;17322287;1881919;22814378;24374639;33481703;33491328;9169872;9742088", "class_list": "", "function": "Specific binding to the autonomously replicating sequence 1 (ARS1). Interaction with regulatory regions: probably involved in compacting the mitochondrial genome. It might play a positive role in gene expression and replication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZP6;Q712M5", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0000262 mitochondrial chromosome", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0000001 mitochondrion inheritance;GO:0090139 mitochondrial chromosome packaging", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q02486-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02555-1", "uniprot_id": "RNT1_YEAST", "mass": 54071.0, "length": 471, "protein_name": "Ribonuclease 3", "gene_name": "RNT1", "organism": "Yeast", "refseq_name": "ribonuclease III", "refseq_ac": "NP_013966", "gene_names_uniprotkb": "RNT1; YM9408.01C; YM9959.21", "gene_names_refseq": "RNT1", "protein_names_uniprotkb": "Ribonuclease 3; 3.1.26.3; RNase III; Ribonuclease III", "protein_names_refseq": "ribonuclease III", "tax_id": 559292, "disease": "brain disease (Disease Ontology:DOID:936)", "pathway": " (sce:YMR239C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;23749301;24374639;33491328;8620530;9169872", "class_list": "", "function": "DsRNA-specific nuclease that cleaves eukaryotic pre-ribosomal RNA at the U3 snoRNP-dependent A0 site in the 5'-external transcribed spacer (ETS) and in the 3'-ETS. In vitro, cleaves synthetic 5'-ETS RNA A0 site in the absence of snoRNA or other factors. Has an essential growth function in addition to pre-rRNA processing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W065;Q04008;Q05038", "ec_number_list": "", "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0004525 ribonuclease III activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0006325 chromatin organization;GO:0009303 rRNA transcription;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02647-1", "uniprot_id": "DYL1_YEAST", "mass": 10441.0, "length": 92, "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "DYN2", "organism": "Yeast", "refseq_name": "dynein light chain", "refseq_ac": "NP_010712", "gene_names_uniprotkb": "DYN2; SLC1", "gene_names_refseq": "DYN2; SLC1", "protein_names_uniprotkb": "Dynein light chain 1, cytoplasmic", "protein_names_refseq": "dynein light chain", "tax_id": 559292, "disease": "cardiac arrest (Disease Ontology:DOID:0060319); hypertension (Disease Ontology:DOID:10763); impotence (Disease Ontology:DOID:1875); middle cerebral artery infarction (Disease Ontology:DOID:3525); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (sce:YDR424C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;17546040;23223634;24374639;25646085;33491328;8628245;9169867", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Also a component of the nuclear pore complex where it may contribute to the stable association of the Nup82 subcomplex with the NPC (PubMed:17546040, PubMed:23223634, PubMed:25646085)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT54", "ec_number_list": "", "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0000132 establishment of mitotic spindle orientation;GO:0040001 establishment of mitotic spindle localization;GO:0051292 nuclear pore complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q02647-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02724-1", "uniprot_id": "ULP1_YEAST", "mass": 72378.0, "length": 621, "protein_name": "Ubiquitin-like-specific protease 1", "gene_name": "ULP1", "organism": "Yeast", "refseq_name": "SUMO protease ULP1", "refseq_ac": "NP_015305", "gene_names_uniprotkb": "ULP1; LPB11C", "gene_names_refseq": "NIB1; ULP1", "protein_names_uniprotkb": "Ubiquitin-like-specific protease 1; 3.4.22.68", "protein_names_refseq": "SUMO protease ULP1", "tax_id": 559292, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (sce:YPL020C); (R-SCE-3065679); (R-SCE-6791226)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10094048;10882122;14562106;15665377;17330950;17563356;18407956;19779198;20702584;21126336;22814378;23749301;24374639;30516470;32597660;33481703;33491328;9169875", "class_list": "", "function": "Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SMT3 to its mature form and deconjugation of SMT3 from targeted proteins. Has an essential role in the G2/M phase of the cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Z2", "ec_number_list": "3.4.22.-;3.4.22.68;2.7.1.-", "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005730 nucleolus", "go_biological_process": "GO:0006508 proteolysis;GO:0000086 G2/M transition of mitotic cell cycle;GO:0016926 protein desumoylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q02724-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02733-1", "uniprot_id": "IRC15_YEAST", "mass": 54156.0, "length": 499, "protein_name": "Increased recombination centers protein 15", "gene_name": "IRC15", "organism": "Yeast", "refseq_name": "Irc15p", "refseq_ac": "NP_015308", "gene_names_uniprotkb": "IRC15", "gene_names_refseq": "IRC15", "protein_names_uniprotkb": "Increased recombination centers protein 15", "protein_names_refseq": "Irc15p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL017C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562095;14562106;24374639;9169875", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Z5", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016651 oxidoreductase activity, acting on NAD(P)H;GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006312 mitotic recombination;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0006103 2-oxoglutarate metabolic process;GO:0045931 positive regulation of mitotic cell cycle;GO:0007020 microtubule nucleation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02733-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02773-1", "uniprot_id": "RPM2_YEAST", "mass": 139348.0, "length": 1202, "protein_name": "Ribonuclease P protein component, mitochondrial", "gene_name": "RPM2", "organism": "Yeast", "refseq_name": "ribonuclease P", "refseq_ac": "NP_013619", "gene_names_uniprotkb": "RPM2", "gene_names_refseq": "RPM2", "protein_names_uniprotkb": "Ribonuclease P protein component, mitochondrial; 3.1.26.5; RNase P", "protein_names_refseq": "ribonuclease P", "tax_id": 559292, "disease": "", "pathway": " (sce:YML091C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1409716;14562106;19684113;21177495;24374639;9169872", "class_list": "", "function": "Ribonuclease P generates mature tRNA molecules by cleaving their 5'-ends., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0J4", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030677 ribonuclease P complex;GO:0030678 mitochondrial ribonuclease P complex", "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007005 mitochondrion organization;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02775-1", "uniprot_id": "SLU7_YEAST", "mass": 44637.0, "length": 382, "protein_name": "Pre-mRNA-splicing factor SLU7", "gene_name": "SLU7", "organism": "Yeast", "refseq_name": "mRNA splicing protein SLU7", "refseq_ac": "NP_010373", "gene_names_uniprotkb": "SLU7; D4483; SLT17", "gene_names_refseq": "SLT17; SLU7", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SLU7; Synthetic lethal with U2 snRNA protein 17; Synthetic lethal with U5 snRNA protein 7", "protein_names_refseq": "mRNA splicing protein SLU7", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR088C)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10737784;11158289;11290703;11884590;12212850;12403466;1406691;1427075;14562095;14562106;17322287;17330950;17563356;18407956;19756047;19779198;19795423;19823750;20702584;22218487;24374639;30516470;33481703;33491328;7489518;7568198;7664739;8756413;9153314;9169867;9528778", "class_list": "", "function": "Essential protein involved in the second catalytic step of pre-mRNA splicing. Involved in the selection of 3'-type splice sites; this selection could be done via a 3'-splice site-binding factor, PRP16., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS75;P89902;Q6Q5U3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030628 pre-mRNA 3'-splice site binding", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0071021 U2-type post-spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000350 generation of catalytic spliceosome for second transesterification step", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "Q02775-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02783-1", "uniprot_id": "LPE10_YEAST", "mass": 47083.0, "length": 413, "protein_name": "Mitochondrial inner membrane magnesium transporter MFM1", "gene_name": "MFM1", "organism": "Yeast", "refseq_name": "Mfm1p", "refseq_ac": "NP_015265", "gene_names_uniprotkb": "MFM1; LPE10", "gene_names_refseq": "LPE10; MFM1", "protein_names_uniprotkb": "Mitochondrial inner membrane magnesium transporter MFM1; MRS2 function modulating factor 1", "protein_names_refseq": "Mfm1p", "tax_id": 559292, "disease": "demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (sce:YPL060W); (R-SCE-5223345)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11254124;14562095;14562106;17322287;17827224;19756047;20653776;24374639;9169875", "class_list": "", "function": "Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3V4;Q6B1B1", "ec_number_list": "", "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0045016 mitochondrial magnesium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q02783-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02784-1", "uniprot_id": "GLRX5_YEAST", "mass": 16931.0, "length": 150, "protein_name": "Monothiol glutaredoxin-5, mitochondrial", "gene_name": "GRX5", "organism": "Yeast", "refseq_name": "monothiol glutaredoxin GRX5", "refseq_ac": "NP_015266", "gene_names_uniprotkb": "GRX5; LPE13W", "gene_names_refseq": "GRX5", "protein_names_uniprotkb": "Monothiol glutaredoxin-5, mitochondrial", "protein_names_refseq": "monothiol glutaredoxin GRX5", "tax_id": 559292, "disease": "autosomal recessive pyridoxine-refractory sideroblastic anemia 3 (Disease Ontology:DOID:0080343)", "pathway": " (sce:YPL059W); (R-SCE-1362409)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11950925;12730244;14562106;23615440;24374639;27532773;9169875", "class_list": "", "function": "Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:11950925, PubMed:12730244, PubMed:23615440). Receives 2Fe/2S clusters from scaffold protein ISU1 and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:23615440, PubMed:27532773)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3V5", "ec_number_list": "", "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006970 response to osmotic stress;GO:0006879 intracellular iron ion homeostasis;GO:0034599 cellular response to oxidative stress;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q02784-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02804-1", "uniprot_id": "ARL3_YEAST", "mass": 22782.0, "length": 198, "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "ARL3", "organism": "Yeast", "refseq_name": "Arf family GTPase ARL3", "refseq_ac": "NP_015274", "gene_names_uniprotkb": "ARL3; ARP1", "gene_names_refseq": "ARL3", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 3; Arf-like GTPase 3", "protein_names_refseq": "Arf family GTPase ARL3", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL051W); (R-SCE-6811440)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12620188;12620189;14562106;15077113;15077114;17322287;22106047;24374639;9169875;9920936", "class_list": "", "function": "Involved in the targeting of ARL1 to the Golgi. Can bind and hydrolyze GTP., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3W3", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043001 Golgi to plasma membrane protein transport;GO:0034067 protein localization to Golgi apparatus;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q02804-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02887-1", "uniprot_id": "ATG21_YEAST", "mass": 55188.0, "length": 496, "protein_name": "Autophagy-related protein 21", "gene_name": "ATG21", "organism": "Yeast", "refseq_name": "Atg21p", "refseq_ac": "NP_015225", "gene_names_uniprotkb": "ATG21; CVT21; HSV1; MAI1", "gene_names_refseq": "ATG21; HSV1; MAI1", "protein_names_uniprotkb": "Autophagy-related protein 21; Cytoplasm to vacuole transport protein 21; Homologous with SVP1 protein 1; Maturation of proaminopeptidase I protein 1", "protein_names_refseq": "Atg21p", "tax_id": 559292, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (sce:YPL100W); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "11536337;11852075;14536056;14562095;14562106;15103325;15155809;15194695;16876790;17287358;17563356;18407956;18769150;19779198;19793921;20154084;21126336;22108003;23749301;24374639;33481703;33491328;34965436;9169875", "class_list": "", "function": "Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage. Essential for maturation of proaminopeptidase I., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3R6", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0016236 macroautophagy;GO:0006497 protein lipidation;GO:0034497 protein localization to phagophore assembly site;GO:0016050 vesicle organization;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q02887-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02896-1", "uniprot_id": "YDC1_YEAST", "mass": 37231.0, "length": 317, "protein_name": "Alkaline ceramidase YDC1", "gene_name": "YDC1", "organism": "Yeast", "refseq_name": "alkaline dihydroceramidase", "refseq_ac": "NP_015238", "gene_names_uniprotkb": "YDC1; LPG21W", "gene_names_refseq": "YDC1", "protein_names_uniprotkb": "Alkaline ceramidase YDC1; 3.5.1.-; Acyl-CoA-independent ceramide synthase", "protein_names_refseq": "alkaline dihydroceramidase", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); leukodystrophy (Disease Ontology:DOID:10579); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YPL087W); (R-SCE-9845614)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10900202;11694577;16847258;17322287;24374639;24866405;9169875", "class_list": "", "function": "Acyl-CoA-independent ceramide synthase that catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3T0", "ec_number_list": "3.5.1.-", "go_molecular_function": "GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0046514 ceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q02896-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02933-1", "uniprot_id": "RNY1_YEAST", "mass": 50171.0, "length": 434, "protein_name": "Ribonuclease T2-like", "gene_name": "RNY1", "organism": "Yeast", "refseq_name": "ribonuclease T2", "refseq_ac": "NP_015202", "gene_names_uniprotkb": "RNY1", "gene_names_refseq": "RNY1", "protein_names_uniprotkb": "Ribonuclease T2-like; 4.6.1.19; RNase T2-like", "protein_names_refseq": "ribonuclease T2", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); RNASET2-deficient cystic leukoencephalopathy (Disease Ontology:DOID:0081007); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); gastric adenocarcinoma (Disease Ontology:DOID:3717); Lynch syndrome (Disease Ontology:DOID:3883); pulmonary neuroendocrine tumor (Disease Ontology:DOID:5410)", "pathway": " (sce:YPL123C); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11158587;14562106;17322287;19332891;24102742;24374639;9169875", "class_list": "", "function": "Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 4, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W3P4", "ec_number_list": "3.5.3.1;2.4.1.1;2.7.11.13;3.6.4.6;1.11.1.27;1.11.1.25;1.1.1.205;4.6.1.19;3.-.-.-;5.3.4.1", "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity;GO:0033897 ribonuclease T2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005773 vacuole;GO:0005775 vacuolar lumen;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006915 apoptotic process;GO:0000902 cell morphogenesis;GO:0006402 mRNA catabolic process;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q02933-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02939-1", "uniprot_id": "TFB2_YEAST", "mass": 58535.0, "length": 513, "protein_name": "General transcription and DNA repair factor IIH subunit TFB2", "gene_name": "TFB2", "organism": "Yeast", "refseq_name": "TFIIH/NER complex subunit TFB2", "refseq_ac": "NP_015203", "gene_names_uniprotkb": "TFB2", "gene_names_refseq": "TFB2", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH subunit TFB2; RNA polymerase II transcription factor B 52 kDa subunit; RNA polymerase II transcription factor B p52 subunit; RNA polymerase II transcription factor B subunit 2; TFIIH subunit TFB2", "protein_names_refseq": "TFIIH/NER complex subunit TFB2", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL122C); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 14, "publication_count": 13, "publication_id_list": "14500720;14562106;19172752;21126336;22411836;24374639;26483468;27610567;33491328;7961739;8631896;9169875;9235928", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3P5;P87331", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005675 transcription factor TFIIH holo complex;GO:0000112 nucleotide-excision repair factor 3 complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q02939-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02950-1", "uniprot_id": "RT51_YEAST", "mass": 39445.0, "length": 344, "protein_name": "Small ribosomal subunit protein bS1m", "gene_name": "MRP51", "organism": "Yeast", "refseq_name": "mitochondrial 37S ribosomal protein bS1m MRP51", "refseq_ac": "NP_015207", "gene_names_uniprotkb": "MRP51", "gene_names_refseq": "MRP51; bS1m", "protein_names_uniprotkb": "Small ribosomal subunit protein bS1m; 37S ribosomal protein MRP51, mitochondrial", "protein_names_refseq": "mitochondrial 37S ribosomal protein bS1m MRP51", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL118W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11278769;12392552;14562095;14562106;14576278;17322287;17563356;19779198;22814378;23749301;24374639;25609543;28154081;32597660;33491328;9169875;9528754", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. bS1m functionally interacts with the 5'-UTR of mitochondrial mRNAs., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Q0", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070124 mitochondrial translational initiation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q02950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03010-1", "uniprot_id": "UME1_YEAST", "mass": 51022.0, "length": 460, "protein_name": "Transcriptional regulatory protein UME1", "gene_name": "UME1", "organism": "Yeast", "refseq_name": "Ume1p", "refseq_ac": "NP_015186", "gene_names_uniprotkb": "UME1; LPI7C; WTM3", "gene_names_refseq": "UME1; WTM3", "protein_names_uniprotkb": "Transcriptional regulatory protein UME1; WD repeat-containing transcriptional modulator 3", "protein_names_refseq": "Ume1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL139C); (R-SCE-3214815)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12954623;14562095;14562106;16286008;16314178;18407956;24374639;33491328;9169875;9234739", "class_list": "", "function": "Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3M9;P87330", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070210 Rpd3L-Expanded complex;GO:0032221 Rpd3S complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q03010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03034-1", "uniprot_id": "FDC1_YEAST", "mass": 56164.0, "length": 503, "protein_name": "Ferulic acid decarboxylase 1", "gene_name": "FDC1", "organism": "Yeast", "refseq_name": "putative phenylacrylic acid decarboxylase FDC1", "refseq_ac": "NP_010828", "gene_names_uniprotkb": "FDC1; D3703.2", "gene_names_refseq": "FDC1", "protein_names_uniprotkb": "Ferulic acid decarboxylase 1; 4.1.1.102; Phenacrylate decarboxylase", "protein_names_refseq": "putative phenylacrylic acid decarboxylase FDC1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR539W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;20471595;24374639;25647642;25862228;26083754;9169867", "class_list": "", "function": "Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites (PubMed:20471595, PubMed:25647642). Not essential for ubiquinone synthesis (PubMed:20471595)., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTF8", "ec_number_list": "4.1.1.102", "go_molecular_function": "GO:0046872 metal ion binding;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0033494 ferulate metabolic process;GO:0046281 cinnamic acid catabolic process;GO:1901067 ferulate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03034-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03067-1", "uniprot_id": "SGF11_YEAST", "mass": 11285.0, "length": 99, "protein_name": "SAGA complex subunit SGF11", "gene_name": "SGF11", "organism": "Yeast", "refseq_name": "SAGA histone acetyltransferase complex subunit SGF11", "refseq_ac": "NP_015278", "gene_names_uniprotkb": "SGF11", "gene_names_refseq": "SGF11", "protein_names_uniprotkb": "SAGA complex subunit SGF11; 11 kDa SAGA-associated factor; SAGA-associated factor 11", "protein_names_refseq": "SAGA histone acetyltransferase complex subunit SGF11", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL047W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562095;14562106;15260971;15282323;15506919;15657441;15657442;16611979;16855026;17322287;18488019;20007317;20395473;20434206;22771212;24374639;25216679;26912860;28918903;31969703;33864814;9169875", "class_list": "", "function": "Component of the transcription coactivator SAGA complex (PubMed:25216679, PubMed:28918903). SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:31969703). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:15657441). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK. The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). Within the DUB module, the correctly positioned zinc finger domains of SGF11 and SGF73 are both required to fully activate the ubiquitin hydrolase UBP8 (PubMed:15657442, PubMed:20434206). Deubiquitination of H2B is required for the maintenance of steady-state H3 methylation levels. SGF11 is required to recruit UBP8 and SUS1 into the SAGA complex (PubMed:15657441, PubMed:15657442)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3W7", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071819 DUBm complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q03067-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03081-1", "uniprot_id": "MET31_YEAST", "mass": 19557.0, "length": 177, "protein_name": "Transcriptional regulator MET31", "gene_name": "MET31", "organism": "Yeast", "refseq_name": "Met31p", "refseq_ac": "NP_015287", "gene_names_uniprotkb": "MET31; P7102.12", "gene_names_refseq": "MET31", "protein_names_uniprotkb": "Transcriptional regulator MET31; Methionine-requiring protein 31", "protein_names_refseq": "Met31p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL038W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;18407956;24374639;33481703;33491328;9169875;9799240", "class_list": "", "function": "Auxiliary transcriptional regulator of sulfur amino acid metabolism. Involved in the transcriptional activation of MET28., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3X6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042762 regulation of sulfur metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03081-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03096-1", "uniprot_id": "EST3_YEAST", "mass": 20555.0, "length": 181, "protein_name": "Telomere replication protein EST3", "gene_name": "EST3", "organism": "Yeast", "refseq_name": "telomerase subunit EST3", "refseq_ac": "NP_012256", "gene_names_uniprotkb": "EST3", "gene_names_refseq": "EST3", "protein_names_uniprotkb": "Telomere replication protein EST3; Ever shorter telomeres protein 3", "protein_names_refseq": "telomerase subunit EST3", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL009C-A)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10619426;10898986;16418502;16884717;17680761;19172754;24374639;8978029;9169870;9326584;9382847", "class_list": "", "function": "Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 31, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVS0", "ec_number_list": "", "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003924 GTPase activity;GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0007004 telomere maintenance via telomerase;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q03096-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03103-1", "uniprot_id": "ERO1_YEAST", "mass": 65033.0, "length": 563, "protein_name": "Endoplasmic oxidoreductin-1", "gene_name": "ERO1", "organism": "Yeast", "refseq_name": "ER oxidoreductin", "refseq_ac": "NP_013576", "gene_names_uniprotkb": "ERO1; YM4987.05C", "gene_names_refseq": "ERO1", "protein_names_uniprotkb": "Endoplasmic oxidoreductin-1; 1.8.3.2; Endoplasmic reticulum oxidoreductase protein 1", "protein_names_refseq": "ER oxidoreductin", "tax_id": 559292, "disease": "", "pathway": " (sce:YML130C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10549279;10982384;11090354;11707280;12453408;14757749;15163408;17322287;17448992;24374639;33491328;9169872;9659913;9659914", "class_list": "", "function": "Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Also able to oxidize directly the PDI related protein MPD2. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI1 and related proteins. Reoxidation of ERO1 probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6W0F5;E9P913", "ec_number_list": "1.8.3.2", "go_molecular_function": "GO:0071949 FAD binding;GO:0015035 protein-disulfide reductase activity;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0016972 thiol oxidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034975 protein folding in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q03103-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03124-1", "uniprot_id": "RSC9_YEAST", "mass": 65218.0, "length": 581, "protein_name": "Chromatin structure-remodeling complex subunit RSC9", "gene_name": "RSC9", "organism": "Yeast", "refseq_name": "Rsc9p", "refseq_ac": "NP_013579", "gene_names_uniprotkb": "RSC9; YM4987.08", "gene_names_refseq": "RSC9", "protein_names_uniprotkb": "Chromatin structure-remodeling complex subunit RSC9; RSC complex subunit RSC9; Remodel the structure of chromatin complex subunit 9", "protein_names_refseq": "Rsc9p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML127W)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10025404;10329629;10619019;11931764;12072455;12183366;12524530;12697820;14562106;17563356;18407956;19779198;19795423;19823750;23749301;24374639;32597660;33481703;33491328;8980231;9169872", "class_list": "", "function": "Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning (PubMed:10025404, PubMed:10329629, PubMed:11931764, PubMed:12072455, PubMed:8980231). RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA (PubMed:10025404, PubMed:10329629). The reaction requires ATP and involves an activated RSC-nucleosome intermediate (PubMed:12183366). Remodeling reaction also involves DNA translocation, DNA twist and conformational change (PubMed:12183366). As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton (PubMed:12072455, PubMed:12697820). This subunit plays a role in transcriptional response to stress (PubMed:11931764). It is involved in both repression and activation of mRNAs regulated by the target of rapamycin (TOR) kinases, and in the synthesis of rRNA (PubMed:10329629, PubMed:11931764)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0F8", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0009303 rRNA transcription;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q03124-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03125-1", "uniprot_id": "NRG1_YEAST", "mass": 26743.0, "length": 231, "protein_name": "Transcriptional regulator NRG1", "gene_name": "NRG1", "organism": "Yeast", "refseq_name": "transcriptional regulator NRG1", "refseq_ac": "NP_010328", "gene_names_uniprotkb": "NRG1; MSS1; YD5112.01C", "gene_names_refseq": "NRG1", "protein_names_uniprotkb": "Transcriptional regulator NRG1; Zinc finger protein MSS1", "protein_names_refseq": "transcriptional regulator NRG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR043C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;16607517;17322287;18407956;19684113;19779198;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Transcriptional repressor involved in regulation of glucose repression. Binds to UAS-1 in the STA1 promoter., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS31", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0031519 PcG protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043709 cell adhesion involved in single-species biofilm formation;GO:0090606 single-species surface biofilm formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q03125-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03144-1", "uniprot_id": "SNO1_YEAST", "mass": 24907.0, "length": 224, "protein_name": "Pyridoxal 5'-phosphate synthase subunit SNO1", "gene_name": "SNO1", "organism": "Yeast", "refseq_name": "putative pyridoxal 5'-phosphate synthase", "refseq_ac": "NP_013813", "gene_names_uniprotkb": "SNO1; YM6543.02C", "gene_names_refseq": "SNO1", "protein_names_uniprotkb": "Pyridoxal 5'-phosphate synthase subunit SNO1; 3.5.1.2; 4.3.3.6; PDX2 homolog 1; Pdx2.1; Pyridoxal 5'-phosphate synthase glutaminase subunit", "protein_names_refseq": "putative pyridoxal 5'-phosphate synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR095C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12271461;14764090;17322287;24374639;9169872", "class_list": "", "function": "Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZR8", "ec_number_list": "6.3.5.5;6.3.4.16;2.1.3.2;3.5.1.2;4.3.2.10;4.3.3.6", "go_molecular_function": "GO:0004359 glutaminase activity;GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1903600 glutaminase complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0008615 pyridoxine biosynthetic process;GO:0006543 L-glutamine catabolic process;GO:0042823 pyridoxal phosphate biosynthetic process;GO:0008614 pyridoxine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q03144-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03148-1", "uniprot_id": "SNZ1_YEAST", "mass": 31817.0, "length": 297, "protein_name": "Pyridoxal 5'-phosphate synthase subunit SNZ1", "gene_name": "SNZ1", "organism": "Yeast", "refseq_name": "pyridoxine biosynthesis protein SNZ1", "refseq_ac": "NP_013814", "gene_names_uniprotkb": "SNZ1; YM6543.03", "gene_names_refseq": "SNZ1", "protein_names_uniprotkb": "Pyridoxal 5'-phosphate synthase subunit SNZ1; 4.3.3.6; PDX1 homolog 1; PLP synthase subunit SNZ1; Pdx1.1; p35", "protein_names_refseq": "pyridoxine biosynthesis protein SNZ1", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR096W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12271461;12649274;14764090;19523954;20919991;24374639;33491328;8955308;9169872;9791124", "class_list": "", "function": "Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZR9", "ec_number_list": "3.5.1.2;4.3.3.6", "go_molecular_function": "GO:0016843 amine-lyase activity;GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity", "go_cellular_component": "GO:1903600 glutaminase complex", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0008615 pyridoxine biosynthetic process;GO:0006543 L-glutamine catabolic process;GO:0042823 pyridoxal phosphate biosynthetic process;GO:0042819 vitamin B6 biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q03148-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03162-1", "uniprot_id": "MUB1_YEAST", "mass": 72251.0, "length": 620, "protein_name": "MYND-type zinc finger protein MUB1", "gene_name": "MUB1", "organism": "Yeast", "refseq_name": "MYND-type zinc finger protein MUB1", "refseq_ac": "NP_013818", "gene_names_uniprotkb": "MUB1; YM6543.07", "gene_names_refseq": "MUB1", "protein_names_uniprotkb": "MYND-type zinc finger protein MUB1; Multi-budding protein", "protein_names_refseq": "MYND-type zinc finger protein MUB1", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR100W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;18070918;24374639;33481703;33491328;9169872;9427754", "class_list": "", "function": "Involved in the determination of the onset of polarized growth. Required for the ubiquitin-dependent degradation of RPN4. Cooperates with UBR2 to transfer ubiquitin from RAD6 to RPN4., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZS3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:1990304 MUB1-RAD6-UBR2 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0007163 establishment or maintenance of cell polarity;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q03162-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03178-1", "uniprot_id": "PIR1_YEAST", "mass": 34622.0, "length": 341, "protein_name": "Cell wall mannoprotein PIR1", "gene_name": "PIR1", "organism": "Yeast", "refseq_name": "beta-1,3-glucan linked protein", "refseq_ac": "NP_012757", "gene_names_uniprotkb": "PIR1; CCW6; YKL618", "gene_names_refseq": "CCW6; PIR1", "protein_names_uniprotkb": "Cell wall mannoprotein PIR1; Covalently-linked cell wall protein 6; Protein with internal repeats 1", "protein_names_refseq": "beta-1,3-glucan linked protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL164C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10407261;10594829;11309124;14562106;15116342;15470095;15781460;16086015;24374639;33481703;8091859;8196765;8322511;9192695;9301021", "class_list": "", "function": "Component of the outer cell wall layer. Required for stability of the cell wall and for optimal growth. Required for resistance against several antifungal and cell wall-perturbing agents and for tolerance to heat shock., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX35", "ec_number_list": "", "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0034399 nuclear periphery;GO:0005621 cellular bud scar;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q03178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03180-1", "uniprot_id": "PIR3_YEAST", "mass": 33004.0, "length": 325, "protein_name": "Cell wall mannoprotein PIR3", "gene_name": "PIR3", "organism": "Yeast", "refseq_name": "beta-1,3-glucan linked protein", "refseq_ac": "NP_012758", "gene_names_uniprotkb": "PIR3; CCW8; YKL617", "gene_names_refseq": "CCW8; PIR3", "protein_names_uniprotkb": "Cell wall mannoprotein PIR3; Covalently-linked cell wall protein 8; Protein with internal repeats 3", "protein_names_refseq": "beta-1,3-glucan linked protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL163W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10407261;10594829;11309124;15116342;15470095;15781460;16086015;17617218;24374639;8091859;8196765;8314797;8322511;9192695;9301021", "class_list": "", "function": "Component of the outer cell wall layer. Required for stability of the cell wall and for optimal growth. Required for resistance against several antifungal and cell wall-perturbing agents., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX36", "ec_number_list": "", "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q03180-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03262-1", "uniprot_id": "PGM3_YEAST", "mass": 71069.0, "length": 622, "protein_name": "Phosphoribomutase", "gene_name": "PRM15", "organism": "Yeast", "refseq_name": "phosphoribomutase PRM15", "refseq_ac": "NP_014005", "gene_names_uniprotkb": "PRM15; PGM3; YM8021.04", "gene_names_refseq": "PGM3; PRM15", "protein_names_uniprotkb": "Phosphoribomutase; 5.4.2.7; PGM 3; PRM; Phosphoglucomutase 3", "protein_names_refseq": "phosphoribomutase PRM15", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR278W); (R-SCE-6798695); (R-SCE-70171); (R-SCE-71336)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "14562095;14562106;15665377;17330950;18042468;18407956;19779198;19795423;19823750;23103740;23273919;23670538;24374639;27821475;32597660;33491328;9169872", "class_list": "", "function": "Major phosphoribomutase that converts ribose 1-phosphate to ribose 5-phosphate. Involved in ribose salvage via the pentose phosphate pathway., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0A5", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008973 phosphopentomutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0006166 purine ribonucleoside salvage;GO:0006148 inosine catabolic process;GO:0046115 guanosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03262-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03280-1", "uniprot_id": "TOM1_YEAST", "mass": 374185.0, "length": 3268, "protein_name": "E3 ubiquitin-protein ligase TOM1", "gene_name": "TOM1", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase TOM1", "refseq_ac": "NP_010745", "gene_names_uniprotkb": "TOM1; D8035.1; SSR2", "gene_names_refseq": "TOM1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TOM1; 2.3.2.26; HECT-type E3 ubiquitin transferase TOM1; Suppressor of snRNA protein 2; Temperature-dependent organization in mitotic nucleus protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase TOM1", "tax_id": 559292, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Turner type (Disease Ontology:DOID:0060811); non-syndromic X-linked intellectual disability 50 (Disease Ontology:DOID:0112029)", "pathway": " (sce:YDR457W); (R-SCE-6798695); (R-SCE-983168)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "10395901;10660055;10873801;11027267;11238398;14562095;14562106;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;23749301;24374639;30516470;32597660;33481703;33491328;9169867;9753545", "class_list": "", "function": "Probable ubiquitin ligase protein involved in many cellular processes, such as transcription regulation, maintenance of nuclear structure, cell cycle, mRNA export and rRNA maturation. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Involved in transcription regulation by interacting, and probably mediating, ubiquitination of some subunit of the SAGA complex. Required for SPT7 ubiquitination. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins. Required for the shuttling of hnRNP protein NAB2, probably by mediating ubiquitination of a protein associated with NAB2. Also required for full induction of the general stress and heat-shock responses. Involved in 18S rRNA maturation by affecting several early steps in the rRNA processing pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT81;Q7LIK7", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;2.3.2.23;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;2.3.2.27;1.1.1.42;6.2.1.45;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;2.3.2.-;2.3.2.26;5.4.2.2;1.11.1.24;2.7.4.6;2.3.2.31;2.4.1.186;1.1.1.205;2.7.1.35;1.14.11.27;3.4.19.12;2.4.2.7;2.3.2.34;5.4.2.7;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;6.3.2.-", "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0016567 protein ubiquitination;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q03280-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03290-1", "uniprot_id": "TFB3_YEAST", "mass": 38128.0, "length": 321, "protein_name": "RNA polymerase II transcription factor B subunit 3", "gene_name": "TFB3", "organism": "Yeast", "refseq_name": "TFIIH/NER complex subunit TFB3", "refseq_ac": "NP_010748", "gene_names_uniprotkb": "TFB3; RIG2", "gene_names_refseq": "RIG2; TFB3", "protein_names_uniprotkb": "RNA polymerase II transcription factor B subunit 3; RNA polymerase II transcription factor B 38 kDa subunit; RNA polymerase II transcription factor B p38 subunit", "protein_names_refseq": "TFIIH/NER complex subunit TFB3", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR460W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 14, "publication_count": 22, "publication_id_list": "11839796;14500720;14562106;15665377;17330950;17563356;17956857;18407956;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169867;9235928;9294030", "class_list": "", "function": "Acts as a component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT84;P89104", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005675 transcription factor TFIIH holo complex;GO:0070985 transcription factor TFIIK complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q03290-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03305-1", "uniprot_id": "RMT2_YEAST", "mass": 47469.0, "length": 412, "protein_name": "Protein arginine N-methyltransferase 2", "gene_name": "RMT2", "organism": "Yeast", "refseq_name": "protein-arginine N5-methyltransferase", "refseq_ac": "NP_010753", "gene_names_uniprotkb": "RMT2", "gene_names_refseq": "RMT2", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 2; 2.1.1.-; Protein-arginine N5-methyltransferase; Type IV PRMT; Type IV protein arginine N-methyltransferase", "protein_names_refseq": "protein-arginine N5-methyltransferase", "tax_id": 559292, "disease": "guanidinoacetate methyltransferase deficiency (Disease Ontology:DOID:0050799); pre-eclampsia (Disease Ontology:DOID:10591); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YDR465C); (R-SCE-71288)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "11856739;14562095;14562106;17330950;17448464;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169867;9873020", "class_list": "", "function": "S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins (PubMed:9873020). Monomethylates ribosomal protein L12 (RPL12A/RPL12B) at 'Arg-67' (PubMed:11856739)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT90", "ec_number_list": "2.1.1.-", "go_molecular_function": "GO:0019702 protein arginine N5-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0018216 peptidyl-arginine methylation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q03305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03306-1", "uniprot_id": "PKH3_YEAST", "mass": 100476.0, "length": 898, "protein_name": "Serine/threonine-protein kinase PKH3", "gene_name": "PKH3", "organism": "Yeast", "refseq_name": "protein kinase PKH3", "refseq_ac": "NP_010754", "gene_names_uniprotkb": "PKH3", "gene_names_refseq": "PKH3", "protein_names_uniprotkb": "Serine/threonine-protein kinase PKH3; 2.7.11.1; Pkb-activating kinase homolog 3", "protein_names_refseq": "protein kinase PKH3", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (sce:YDR466W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10567559;11062466;11875433;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;23749301;24374639;32597660;33229814;33481703;33491328;9169867", "class_list": "", "function": "Serine/threonine-protein kinase which may phosphorylate the same targets substrates as PKH1 and PKH2, 2 upstream activators of PKC1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "D6VT91", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000196 cell integrity MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q03306-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03323-1", "uniprot_id": "SDC1_YEAST", "mass": 19446.0, "length": 175, "protein_name": "COMPASS component SDC1", "gene_name": "SDC1", "organism": "Yeast", "refseq_name": "Sdc1p", "refseq_ac": "NP_010757", "gene_names_uniprotkb": "SDC1; CPS25; SAF19", "gene_names_refseq": "CPS25; SAF19; SDC1", "protein_names_uniprotkb": "COMPASS component SDC1; Complex proteins associated with SET1 protein SDC1; Set1C component SDC1; Suppressor of CDC25 protein 1", "protein_names_refseq": "Sdc1p", "tax_id": 559292, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YDR469W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11687631;11742990;11752412;11805083;14562095;14562106;18407956;21126336;23749301;24374639;25542209;29071121;30100186;31922488;33481703;33491328;9169867", "class_list": "", "function": "Component of the Set1C/COMPASS complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation (PubMed:11742990, PubMed:11805083). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (PubMed:31922488)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT93", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0048188 Set1C/COMPASS complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03323-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03330-1", "uniprot_id": "GCN5_YEAST", "mass": 51069.0, "length": 439, "protein_name": "Histone acetyltransferase GCN5", "gene_name": "GCN5", "organism": "Yeast", "refseq_name": "histone acetyltransferase GCN5", "refseq_ac": "NP_011768", "gene_names_uniprotkb": "GCN5; ADA4; SWI9", "gene_names_refseq": "AAS104; ADA4; GCN5; KAT2; SWI9", "protein_names_uniprotkb": "Histone acetyltransferase GCN5; 2.3.1.-; 2.3.1.48; Histone crotonyltransferase GCN5; SAGA complex subunit GCN5", "protein_names_refseq": "histone acetyltransferase GCN5", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); breast cancer (Disease Ontology:DOID:1612); familial nephrotic syndrome (Disease Ontology:DOID:2590); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (sce:YGR252W); (R-SCE-9018519)", "pathway_count": 2, "publication_count": 43, "publication_id_list": "10026213;10430873;10490601;10549298;10864329;10940244;11080160;11545749;12186975;12446794;1396595;14562106;15260971;15340070;15647753;16543222;16543223;17189264;17322287;18039853;18458063;19822662;19841091;20126658;21126336;22932476;24374639;25216679;28918903;30224453;31699900;32597660;33491328;33864814;7862114;7957049;9133741;9133742;9154821;9169869;9224714;9674426;9885573", "class_list": "", "function": "Histone acetyltransferase that acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K9ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac and H3K36ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation and elongation. Operates in concert with certain DNA-binding transcriptional activators such as GCN4 or HAP2/3/4. Its acetyltransferase activity seems to be dependent on the association in different multisubunit complexes (PubMed:10026213, PubMed:11545749, PubMed:16543222, PubMed:16543223, PubMed:17189264, PubMed:19822662). Component of the transcription coactivator SAGA complex. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription (PubMed:10864329, PubMed:25216679, PubMed:28918903). At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module) (PubMed:25216679). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B (PubMed:10026213, PubMed:18458063). SAGA interacts with DNA via upstream activating sequences (UASs) (PubMed:28918903). Also identified in a modified version of SAGA named SALSA or SLIK (PubMed:12186975, PubMed:12446794). The cleavage of SPT7 and the absence of the SPT8 subunit in SLIK neither drive any major conformational differences in its structure compared with SAGA, nor significantly affect HAT, DUB, or DNA-binding activities (PubMed:33864814). Component of the ADA histone acetyltransferase complex, which preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (PubMed:10026213, PubMed:9224714). In addition to histone acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and is able to mediate histone crotonylation (PubMed:31699900). Controls the metaphase-to-anaphase transition and is required for correct chromosome segregation and centromere/kinetochore function in mitosis (PubMed:18039853). May be involved in response to DNA damage by genotoxic agents (PubMed:15340070)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VV32;Q6B165", "ec_number_list": "3.6.4.13;2.3.1.48;2.1.1.319;2.3.1.-", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0140068 histone crotonyltransferase activity;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity;GO:0010484 histone H3 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000123 histone acetyltransferase complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q03330-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03338-1", "uniprot_id": "PRP3_YEAST", "mass": 55870.0, "length": 469, "protein_name": "U4/U6 small nuclear ribonucleoprotein PRP3", "gene_name": "PRP3", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit PRP3", "refseq_ac": "NP_010761", "gene_names_uniprotkb": "PRP3; D8035.16; RNA3", "gene_names_refseq": "PRP3; RNA3", "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein PRP3; Pre-mRNA-splicing factor 3", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit PRP3", "tax_id": 559292, "disease": "retinitis pigmentosa 18 (Disease Ontology:DOID:0110356); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (sce:YDR473C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10449419;14562106;17287358;18407956;18953335;24374639;32597660;33481703;33491328;9169867;9326489", "class_list": "", "function": "Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT97", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q03338-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03388-1", "uniprot_id": "VPS72_YEAST", "mass": 90580.0, "length": 795, "protein_name": "Vacuolar protein sorting-associated protein 72", "gene_name": "VPS72", "organism": "Yeast", "refseq_name": "Vps72p", "refseq_ac": "NP_010773", "gene_names_uniprotkb": "VPS72; SWC2", "gene_names_refseq": "SWC2; VPS72", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 72; SWR complex protein 2", "protein_names_refseq": "Vps72p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR485C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12134085;12748633;14562095;14562106;14645854;14690608;15045029;16299513;17322287;17563356;18407956;19779198;21126336;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Participates in the catalytic exchange of histone H2A for the H2A variant HTZ1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes. Indirectly involved in vacuolar protein sorting., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VTA8", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q03388-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03390-1", "uniprot_id": "VPS60_YEAST", "mass": 25862.0, "length": 229, "protein_name": "Vacuolar protein-sorting-associated protein 60", "gene_name": "VPS60", "organism": "Yeast", "refseq_name": "Vps60p", "refseq_ac": "NP_010774", "gene_names_uniprotkb": "VPS60; CHM5; MOS10", "gene_names_refseq": "CHM5; MOS10; VPS60", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 60; Charged multivesicular body protein 5", "protein_names_refseq": "Vps60p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR486C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11559748;12748633;14562095;14562106;14701806;17322287;18032584;18194652;19779198;23749301;24374639;33481703;33491328;9169867", "class_list": "", "function": "Has a role in a late stage of multivesicular body (MVB) formation. Can stimulate VPS4 ATPase activity via VTA1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTA9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005771 multivesicular body;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0006900 vesicle budding from membrane;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q03390-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03429-1", "uniprot_id": "MZM1_YEAST", "mass": 13927.0, "length": 123, "protein_name": "Mitochondrial zinc maintenance protein 1, mitochondrial", "gene_name": "MZM1", "organism": "Yeast", "refseq_name": "Mzm1p", "refseq_ac": "NP_010781", "gene_names_uniprotkb": "MZM1; AIM8; FMP36", "gene_names_refseq": "AIM8; FMP36; MZM1", "protein_names_uniprotkb": "Mitochondrial zinc maintenance protein 1, mitochondrial; Altered inheritance of mitochondria protein 8; Found in mitochondrial proteome protein 36", "protein_names_refseq": "Mzm1p", "tax_id": 559292, "disease": "mitochondrial complex III deficiency nuclear type 8 (Disease Ontology:DOID:0080117); mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (sce:YDR493W); (R-SCE-9865881)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562095;14562106;14576278;17322287;19300474;20404342;21807901;24374639;9169867", "class_list": "", "function": "Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTB5", "ec_number_list": "", "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03429-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03434-1", "uniprot_id": "YM12B_YEAST", "mass": 198572.0, "length": 1755, "protein_name": "Transposon Ty1-ML2 Gag-Pol polyprotein", "gene_name": "TY1B-ML2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_013672", "gene_names_uniprotkb": "TY1B-ML2; YM8054.04; YMLWTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-ML2 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YML039W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169872;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VZD5", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q03434-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03455-1", "uniprot_id": "MSC2_YEAST", "mass": 80578.0, "length": 724, "protein_name": "Probable zinc transporter MSC2", "gene_name": "MSC2", "organism": "Yeast", "refseq_name": "metal cation transporter MSC2", "refseq_ac": "NP_010491", "gene_names_uniprotkb": "MSC2; YD8142.02", "gene_names_refseq": "MSC2", "protein_names_uniprotkb": "Probable zinc transporter MSC2; Meiotic sister chromatid recombination protein 2", "protein_names_refseq": "metal cation transporter MSC2", "tax_id": 559292, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": " (sce:YDR205W); (R-SCE-264876); (R-SCE-435368)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10511544;11058603;12748633;14562095;14562106;16847258;24374639;33491328;9169867", "class_list": "", "function": "Probably act as a zinc ion transporter moving zinc from the nucleus/endoplasmic reticulum to the cytoplasm. Involved in zinc ion homeostasis and cellular distribution., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSI6", "ec_number_list": "", "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006829 zinc ion transport;GO:0055085 transmembrane transport;GO:0006882 intracellular zinc ion homeostasis;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03455-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03465-1", "uniprot_id": "RPN4_YEAST", "mass": 60153.0, "length": 531, "protein_name": "Protein RPN4", "gene_name": "RPN4", "organism": "Yeast", "refseq_name": "stress-regulated transcription factor RPN4", "refseq_ac": "NP_010264", "gene_names_uniprotkb": "RPN4; D2840; SON1; UFD5", "gene_names_refseq": "RPN4; SON1; UFD5", "protein_names_uniprotkb": "Protein RPN4; Nuclear protein SON1; Ubiquitin fusion degradation protein 5", "protein_names_refseq": "stress-regulated transcription factor RPN4", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL020C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10350051;11248031;15504724;17322287;17532487;18070918;19779198;23749301;24374639;33481703;7615550;8514125;9169867;9512348", "class_list": "", "function": "Acts as a transcriptional activator of a number of genes encoding proteasomal subunits. Binds to a PACE (proteasome-associated control element) DNA sequence 5'-GGTGGCAAA-3'. Its expression is in turn regulated by the 26S proteasome, thereby providing a negative feedback control mechanism. Required for normal growth at low temperatures., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRX0;E9P944", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033554 cellular response to stress;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q03465-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03466-1", "uniprot_id": "EBS1_YEAST", "mass": 100000.0, "length": 884, "protein_name": "Nonsense-mediated mRNA decay factor EBS1", "gene_name": "EBS1", "organism": "Yeast", "refseq_name": "Ebs1p", "refseq_ac": "NP_010492", "gene_names_uniprotkb": "EBS1; YD8142.03", "gene_names_refseq": "EBS1", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor EBS1; EST1-like BCY1 suppressor 1", "protein_names_refseq": "Ebs1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR206W); (R-SCE-975957)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10688642;16467471;17984081;23749301;24374639;29897761;33491328;9169867", "class_list": "", "function": "Plays a role in nonsense-mediated mRNA decay (NMD) (PubMed:16467471, PubMed:17984081). Recruits UPF1 to cytoplasmic mRNA decay bodies (P-bodies) (PubMed:17984081). Negative regulator of gene expression. Inhibits translation most likely through effects on eIF-4E (CDC33) (PubMed:16467471). Involved in telomere maintenance (PubMed:10688642)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSI7", "ec_number_list": "", "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006310 DNA recombination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03466-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03494-1", "uniprot_id": "YD22B_YEAST", "mass": 202095.0, "length": 1770, "protein_name": "Transposon Ty2-DR2 Gag-Pol polyprotein", "gene_name": "TY2B-DR2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058142", "gene_names_uniprotkb": "TY2B-DR2; YD8142A.09; YDRWTy2-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty2-DR2 Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR210W-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;17287358;24374639;9169867;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSJ1", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q03494-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03503-1", "uniprot_id": "NAA30_YEAST", "mass": 20457.0, "length": 176, "protein_name": "N-alpha-acetyltransferase 30", "gene_name": "MAK3", "organism": "Yeast", "refseq_name": "peptide alpha-N-acetyltransferase MAK3", "refseq_ac": "NP_015376", "gene_names_uniprotkb": "MAK3; NAA30; YP9499.08", "gene_names_refseq": "MAK3; NAA30", "protein_names_uniprotkb": "N-alpha-acetyltransferase 30; 2.3.1.256; L-A virus GAG protein N-acetyltransferase subunit MAK3; Maintenance of killer protein 3; N-terminal acetyltransferase C complex catalytic subunit MAK3; NatC catalytic subunit; NatC complex subunit MAK3", "protein_names_refseq": "peptide alpha-N-acetyltransferase MAK3", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR051W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11274203;1339437;1400344;14562095;14562106;17261844;22814378;24374639;9169875", "class_list": "", "function": "Catalytic component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus GAG protein and possibly GRH1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W458", "ec_number_list": "2.3.1.256;2.3.1.258", "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031417 NatC complex", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03503-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03533-1", "uniprot_id": "TDA1_YEAST", "mass": 66220.0, "length": 586, "protein_name": "Serine/threonine-protein kinase TDA1", "gene_name": "TDA1", "organism": "Yeast", "refseq_name": "protein kinase TDA1", "refseq_ac": "NP_014019", "gene_names_uniprotkb": "TDA1", "gene_names_refseq": "TDA1", "protein_names_uniprotkb": "Serine/threonine-protein kinase TDA1; 2.7.11.1; Topoisomerase I damage affected protein 1", "protein_names_refseq": "protein kinase TDA1", "tax_id": 559292, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); uterine fibroid (Disease Ontology:DOID:13223)", "pathway": " (sce:YMR291W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11062466;14562095;14562106;15665377;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21173034;21177495;21460040;22814378;23749301;24374639;30516470;32597660;33229814;33372657;33481703;33491328;9169872", "class_list": "", "function": "Serine/threonine protein kinase shown to have protein phosphorylation activity in vitro., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 17, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 17, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 17, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 51, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "D6W0B8", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0034599 cellular response to oxidative stress;GO:0018105 peptidyl-serine phosphorylation;GO:1904547 regulation of cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q03533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03554-1", "uniprot_id": "GOT1_YEAST", "mass": 15431.0, "length": 138, "protein_name": "Protein transport protein GOT1", "gene_name": "GOT1", "organism": "Yeast", "refseq_name": "Got1p", "refseq_ac": "NP_014020", "gene_names_uniprotkb": "GOT1", "gene_names_refseq": "GOT1", "protein_names_uniprotkb": "Protein transport protein GOT1; Golgi transport protein 1", "protein_names_refseq": "Got1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR292W)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10406798;24374639;9169872", "class_list": "", "function": "Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex. Can be replaced by SFT2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0B9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q03554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03557-1", "uniprot_id": "GATA_YEAST", "mass": 50919.0, "length": 464, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial", "gene_name": "HER2", "organism": "Yeast", "refseq_name": "glutamyl-tRNA(Gln) amidotransferase subunit HER2", "refseq_ac": "NP_014021", "gene_names_uniprotkb": "HER2; GEP6; LRC6", "gene_names_refseq": "GEP6; HER2; QRS1; RRG6", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; 6.3.5.7; Glu-AdT subunit A; HMG2-induced ER-remodeling protein 2; Loss of respiratory capacity protein 6", "protein_names_refseq": "glutamyl-tRNA(Gln) amidotransferase subunit HER2", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); combined oxidative phosphorylation deficiency 40 (Disease Ontology:DOID:0112117)", "pathway": " (sce:YMR293C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11914276;14562095;14562106;14576278;18667535;19417106;24374639;9169872", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling., [UniProtKB, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0C0", "ec_number_list": "6.3.5.-;6.3.5.7", "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0007029 endoplasmic reticulum organization;GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03557-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03612-1", "uniprot_id": "YE11B_YEAST", "mass": 198562.0, "length": 1755, "protein_name": "Transposon Ty1-ER1 Gag-Pol polyprotein", "gene_name": "TY1B-ER1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_011064", "gene_names_uniprotkb": "TY1B-ER1; YERCTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-ER1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YER138C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;16093680;17287358;24374639;9169868;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DM43", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q03612-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03619-1", "uniprot_id": "YE12B_YEAST", "mass": 198570.0, "length": 1755, "protein_name": "Transposon Ty1-ER2 Gag-Pol polyprotein", "gene_name": "TY1B-ER2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_011087", "gene_names_uniprotkb": "TY1B-ER2; YERCTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-ER2 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YER160C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16093660;16093680;17330950;18407956;19779198;24374639;9169868;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DM67", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03619-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03631-1", "uniprot_id": "WAR1_YEAST", "mass": 107561.0, "length": 944, "protein_name": "Weak acid resistance protein 1", "gene_name": "WAR1", "organism": "Yeast", "refseq_name": "War1p", "refseq_ac": "NP_013635", "gene_names_uniprotkb": "WAR1", "gene_names_refseq": "WAR1", "protein_names_uniprotkb": "Weak acid resistance protein 1", "protein_names_refseq": "War1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML076C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12588995;14562095;14562106;14617816;16911515;17509074;18407956;18621731;19684113;19779198;19795423;19823750;20702584;23749301;24374639;32597660;33229814;33481703;33491328;9169872", "class_list": "", "function": "transcription factor which binds to a weak acid response element (WARE) to mediate stress induction of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6W0K7", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071468 cellular response to acidic pH;GO:0009074 aromatic amino acid family catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q03631-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03640-1", "uniprot_id": "TCB3_YEAST", "mass": 171076.0, "length": 1545, "protein_name": "Tricalbin-3", "gene_name": "TCB3", "organism": "Yeast", "refseq_name": "Tcb3p", "refseq_ac": "NP_013639", "gene_names_uniprotkb": "TCB3", "gene_names_refseq": "TCB3", "protein_names_uniprotkb": "Tricalbin-3", "protein_names_refseq": "Tcb3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML072C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11875433;14562095;14562106;15049706;15141306;15665377;17330950;17563356;17761666;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22250200;23749301;24374639;24909858;32597660;33229814;33481703;33491328;34965436;9169872", "class_list": "", "function": "May play a role in membrane trafficking., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 49, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6VZA1", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0046872 metal ion binding;GO:0008289 lipid binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization;GO:0055091 phospholipid homeostasis;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0035621 ER to Golgi ceramide transport;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q03640-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03649-1", "uniprot_id": "MGL2_YEAST", "mass": 51438.0, "length": 449, "protein_name": "Monoacylglycerol lipase", "gene_name": "MGL2", "organism": "Yeast", "refseq_name": "putative carboxylic ester hydrolase", "refseq_ac": "NP_013937", "gene_names_uniprotkb": "MGL2; YM8261.04", "gene_names_refseq": "MGL2", "protein_names_uniprotkb": "Monoacylglycerol lipase; 3.1.1.23; MAG lipase", "protein_names_refseq": "putative carboxylic ester hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR210W); (R-SCE-1483191)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16361250;22106047;24374639;26991558;29225428;33491328;9169872", "class_list": "", "function": "Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Has a preference for palmitoyl-MAG (PubMed:26991558). Does not play a significant role in ethyl ester biosynthesis (PubMed:16361250). Also possesses ester hydrolase and low but persistent TAG lipase activity (PubMed:29225428)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W035", "ec_number_list": "3.1.1.23;3.1.1.-;2.3.1.84", "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity;GO:0016746 acyltransferase activity;GO:0008126 acetylesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0051793 medium-chain fatty acid catabolic process;GO:0051792 medium-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q03649-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03655-1", "uniprot_id": "GAS3_YEAST", "mass": 56794.0, "length": 524, "protein_name": "Probable 1,3-beta-glucanosyltransferase GAS3", "gene_name": "GAS3", "organism": "Yeast", "refseq_name": "putative 1,3-beta-glucanosyltransferase", "refseq_ac": "NP_013942", "gene_names_uniprotkb": "GAS3; YM8261.09", "gene_names_refseq": "GAS3", "protein_names_uniprotkb": "Probable 1,3-beta-glucanosyltransferase GAS3; 2.4.1.-; Glycolipid-anchored surface protein 3", "protein_names_refseq": "putative 1,3-beta-glucanosyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR215W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11079560;14562106;15781460;17322287;17397106;19756047;24374639;31870255;9169872", "class_list": "", "function": "Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6W040", "ec_number_list": "", "go_molecular_function": "GO:0042124 1,3-beta-glucanosyltransferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization;GO:0071970 fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03655-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03674-1", "uniprot_id": "PLB2_YEAST", "mass": 75455.0, "length": 706, "protein_name": "Lysophospholipase 2", "gene_name": "PLB2", "organism": "Yeast", "refseq_name": "lysophospholipase", "refseq_ac": "NP_013719", "gene_names_uniprotkb": "PLB2; YM8270.08C", "gene_names_refseq": "PLB2", "protein_names_uniprotkb": "Lysophospholipase 2; 3.1.1.5; Phospholipase B 2", "protein_names_refseq": "lysophospholipase", "tax_id": 559292, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); brain ischemia (Disease Ontology:DOID:2316); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (sce:YMR006C); (R-SCE-111995); (R-SCE-1482788); (R-SCE-1482798); (R-SCE-1482801); (R-SCE-1482839); (R-SCE-1482922); (R-SCE-1482925); (R-SCE-1483115); (R-SCE-1483152); (R-SCE-1483166); (R-SCE-2142753); (R-SCE-418592); (R-SCE-432142); (R-SCE-6811436)", "pathway_count": 15, "publication_count": 10, "publication_id_list": "10231538;10497163;14562106;15588231;15781460;17322287;24374639;33229814;33491328;9169872", "class_list": "", "function": "Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. However, it does not display transacylase activity. Substrate preference is phosphatidylserine > phosphatidylinositol > phosphatidylcholine > phosphatidylethanolamine (PubMed:10231538, PubMed:10497163). The substrate specificity is pH- and ion-dependent. In contrast with activities observed at optimum pH 3.5, the order of substrate preference at pH 5.5 is phosphatidylserine = phosphatidylethanolamine > phosphatidylcholine > phosphatidylinositol (PubMed:15588231)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 25, "predicted_n_glycosites": 25, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 29, "binding_glycan_count": 0, "secondary_ac_list": "D6VZI1", "ec_number_list": "2.7.11.24;3.1.1.3;3.1.1.5;3.1.1.-", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0046475 glycerophospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q03674-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03677-1", "uniprot_id": "MTND_YEAST", "mass": 20879.0, "length": 179, "protein_name": "Acireductone dioxygenase", "gene_name": "ADI1", "organism": "Yeast", "refseq_name": "acireductone dioxygenase (Ni2+-requiring)", "refseq_ac": "NP_013722", "gene_names_uniprotkb": "ADI1; YM8270.12", "gene_names_refseq": "ADI1", "protein_names_uniprotkb": "Acireductone dioxygenase; 1.13.11.53; 1.13.11.54; ARD'; ARD; Acireductone dioxygenase (Fe(2+)-requiring); Acireductone dioxygenase (Ni(2+)-requiring); Fe-ARD; Ni-ARD", "protein_names_refseq": "acireductone dioxygenase (Ni2+-requiring)", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR009W); (R-SCE-1237112)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14562095;15938715;15967792;17322287;18625006;24374639;9169872", "class_list": "", "function": "Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:15938715, PubMed:18625006). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZI3", "ec_number_list": "1.13.11.54;1.13.11.53", "go_molecular_function": "GO:0005506 iron ion binding;GO:0016151 nickel cation binding;GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity;GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine;GO:0006555 methionine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q03677-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03687-1", "uniprot_id": "ANY1_YEAST", "mass": 46872.0, "length": 405, "protein_name": "Scramblase ANY1", "gene_name": "ANY1", "organism": "Yeast", "refseq_name": "Any1p", "refseq_ac": "NP_013723", "gene_names_uniprotkb": "ANY1; CFS1; YM8270.13", "gene_names_refseq": "ANY1; CFS1", "protein_names_uniprotkb": "Scramblase ANY1; Antagonizes NEO1 phospholipid flippase protein 1; CDC50 suppressor 1", "protein_names_refseq": "Any1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR010W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;16847258;17322287;23749301;24374639;27811238;28057802;30824614;31786280;33491328;9169872", "class_list": "", "function": "Phospholipid scramblase that transports phosphatidylserine (PS) and phosphatidylethalonamine (PE) bidirectionally from one leaflet to the other of the phospholipid bilayer to at least partially collapse the membrane asymmetry established by NEO1 and other flippases (PubMed:27811238, PubMed:28057802, PubMed:30824614). The PS scramblase activity has been disputed (PubMed:30824614). Functions in the trafficking pathway from endosomes to the trans-Golgi network (TGN) (PubMed:28057802)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZI4", "ec_number_list": "", "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0045332 phospholipid translocation;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q03687-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03690-1", "uniprot_id": "CLU_YEAST", "mass": 145166.0, "length": 1277, "protein_name": "Clustered mitochondria protein 1", "gene_name": "CLU1", "organism": "Yeast", "refseq_name": "translation initiation factor 3 subunit CLU1", "refseq_ac": "NP_013725", "gene_names_uniprotkb": "CLU1; TIF31; YM8270.16", "gene_names_refseq": "CLU1; TIF31", "protein_names_uniprotkb": "Clustered mitochondria protein 1; Translation initiation factor 31; eIF3-associated protein p135", "protein_names_refseq": "translation initiation factor 3 subunit CLU1", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR012W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10358023;14562095;14562106;16215987;17287358;18407956;19779198;19795423;19804647;19823750;21126336;23749301;24374639;33481703;33491328;9169872;9601101", "class_list": "", "function": "mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZI6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0048312 intracellular distribution of mitochondria", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03690-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03691-1", "uniprot_id": "ROT1_YEAST", "mass": 28908.0, "length": 256, "protein_name": "Protein ROT1", "gene_name": "ROT1", "organism": "Yeast", "refseq_name": "Rot1p", "refseq_ac": "NP_013927", "gene_names_uniprotkb": "ROT1; YM8325.01", "gene_names_refseq": "ROT1", "protein_names_uniprotkb": "Protein ROT1; Reversal of TOR2 lethality protein 1", "protein_names_refseq": "Rot1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR200W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;15470097;16567426;16874095;17397129;17606994;17914748;24374639;9038344;9169872;9545237", "class_list": "", "function": "Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies. Controls actin cytoskeleton polarization to the mother-bud neck and CLB2 protein stability., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 3, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W025", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006457 protein folding;GO:0006487 protein N-linked glycosylation;GO:0030950 establishment or maintenance of actin cytoskeleton polarity;GO:0035269 protein O-linked glycosylation via mannose;GO:0006458 'de novo' protein folding", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q03691-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03702-1", "uniprot_id": "CCE1_YEAST", "mass": 41000.0, "length": 353, "protein_name": "Cruciform cutting endonuclease 1, mitochondrial", "gene_name": "CCE1", "organism": "Yeast", "refseq_name": "cruciform cutting endonuclease", "refseq_ac": "NP_012914", "gene_names_uniprotkb": "CCE1; YKL164", "gene_names_refseq": "CCE1; MGT1", "protein_names_uniprotkb": "Cruciform cutting endonuclease 1, mitochondrial; 3.1.21.10", "protein_names_refseq": "cruciform cutting endonuclease", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL011C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10825168;1481574;1537343;24374639;8196765;8609627", "class_list": "", "function": "Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' sequence., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXS5", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004520 DNA endonuclease activity;GO:0000403 Y-form DNA binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0070336 flap-structured DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q03702-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03707-1", "uniprot_id": "SRC1_YEAST", "mass": 95498.0, "length": 834, "protein_name": "Inner nuclear membrane protein SRC1", "gene_name": "SRC1", "organism": "Yeast", "refseq_name": "Src1p", "refseq_ac": "NP_013679", "gene_names_uniprotkb": "SRC1; HEH1; YML033W", "gene_names_refseq": "HEH1; SRC1; YML033W", "protein_names_uniprotkb": "Inner nuclear membrane protein SRC1; Helix-extension-helix domain-containing protein 1", "protein_names_refseq": "Src1p", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); cataract 46 juvenile-onset (Disease Ontology:DOID:0110243)", "pathway": " (sce:YML034W); (R-SCE-9668328)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "11754482;16929305;17287358;17330950;17563356;18407956;18997772;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22814378;23749301;24374639;30516470;32597660;33481703;33491328;9169872", "class_list": "", "function": "Plays a role in sister chromatid separation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 50, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZE1;Q03712", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0034399 nuclear periphery;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0000070 mitotic sister chromatid segregation;GO:0071763 nuclear membrane organization;GO:0043007 maintenance of rDNA;GO:0070550 rDNA chromatin condensation", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q03707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03713-1", "uniprot_id": "RCF1_YEAST", "mass": 18477.0, "length": 159, "protein_name": "Respiratory supercomplex factor 1, mitochondrial", "gene_name": "RCF1", "organism": "Yeast", "refseq_name": "respiratory supercomplex assembly factor RCF1", "refseq_ac": "NP_013682", "gene_names_uniprotkb": "RCF1; AIM31", "gene_names_refseq": "AIM31; RCF1", "protein_names_uniprotkb": "Respiratory supercomplex factor 1, mitochondrial; Altered inheritance of mitochondria protein 31", "protein_names_refseq": "respiratory supercomplex assembly factor RCF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YML030W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;14576278;17322287;19300474;19750512;22310663;22342701;22405070;24374639;29507228;30598554;30683696;31591265;9169872", "class_list": "", "function": "Assembly factor that plays a role in the assembly of the respiratory chain supercomplexes (SCs) composed of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV). Involved in the recruitment of COX13 and RCF2 into cytochrome c oxidase. May also be required for late-stage assembly of the COX12 and COX13 subunits (PubMed:22310663, PubMed:22342701, PubMed:22405070). Required for the generation and maintenance of a normal proton motive force (PMF) across the inner mitochondrial membrane (IMM) by preventing proton leakage through an inactive population of CIV that accumulates when RCF1 and/or RCF2 proteins are absent (PubMed:30683696, PubMed:31591265)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZE4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0010155 regulation of proton transport;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0097250 mitochondrial respirasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q03713-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03718-1", "uniprot_id": "NSE5_YEAST", "mass": 64013.0, "length": 556, "protein_name": "Non-structural maintenance of chromosome element 5", "gene_name": "NSE5", "organism": "Yeast", "refseq_name": "Smc5-Smc6 complex subunit NSE5", "refseq_ac": "NP_013689", "gene_names_uniprotkb": "NSE5", "gene_names_refseq": "NSE5", "protein_names_uniprotkb": "Non-structural maintenance of chromosome element 5; Non-SMC element 5", "protein_names_refseq": "Smc5-Smc6 complex subunit NSE5", "tax_id": 559292, "disease": "", "pathway": " (sce:YML023C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;14690591;15738391;17563356;23749301;24374639;33491328;9169872", "class_list": "", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZF1", "ec_number_list": "", "go_molecular_function": "GO:0042030 ATPase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0140588 chromatin looping", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03718-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03723-1", "uniprot_id": "OST6_YEAST", "mass": 37891.0, "length": 332, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6", "gene_name": "OST6", "organism": "Yeast", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycotransferase", "refseq_ac": "NP_013693", "gene_names_uniprotkb": "OST6", "gene_names_refseq": "OST6", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6; OTase 37 kDa subunit; Oligosaccharyl transferase 37 kDa subunit; Oligosaccharyl transferase subunit OST6", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycotransferase", "tax_id": 559292, "disease": "X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia (Disease Ontology:DOID:0080319); autosomal recessive intellectual developmental disorder 7 (Disease Ontology:DOID:0081183); congenital disorder of glycosylation Icc (Disease Ontology:DOID:0111839); prostate cancer (Disease Ontology:DOID:10283); bacterial infectious disease (Disease Ontology:DOID:104); primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (sce:YML019W); (R-SCE-5223345); (R-SCE-6798695)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10358084;11580295;14562106;15886282;16096345;16096346;16297388;17322287;19549845;24374639;9169872;9878773", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:11580295). Can participate in redox reactions and is able to catalyze dithiol-disulfide exchange reactions with other proteins, albeit with relatively low efficiency. May form transient disulfide bonds with nascent polypeptides in the endoplasmic reticulum and thereby promote efficient glycosylation (PubMed:19549845)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZF5;E9P904", "ec_number_list": "", "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q03723-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03750-1", "uniprot_id": "TAF8_YEAST", "mass": 57986.0, "length": 510, "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "TAF8", "organism": "Yeast", "refseq_name": "Taf8p", "refseq_ac": "NP_013593", "gene_names_uniprotkb": "TAF8; TAF65; YM8339.05C", "gene_names_refseq": "TAF65; TAF8", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 8; TAFII-65; TBP-associated factor 65 kDa; TBP-associated factor 8", "protein_names_refseq": "Taf8p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML114C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10788514;11238921;11295558;12093743;12138208;12516863;14562095;14562106;18407956;19779198;22814378;23749301;24374639;33481703;33491328;9169872;9695952", "class_list": "", "function": "Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0H0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q03750-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03758-1", "uniprot_id": "BUL2_YEAST", "mass": 104786.0, "length": 920, "protein_name": "Ubiquitin ligase-binding protein BUL2", "gene_name": "BUL2", "organism": "Yeast", "refseq_name": "ubiquitin-ubiquitin ligase BUL2", "refseq_ac": "NP_013596", "gene_names_uniprotkb": "BUL2; YM8339.08", "gene_names_refseq": "BUL2", "protein_names_uniprotkb": "Ubiquitin ligase-binding protein BUL2", "protein_names_refseq": "ubiquitin-ubiquitin ligase BUL2", "tax_id": 559292, "disease": "", "pathway": " (sce:YML111W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10958669;11352928;11500494;12821147;14560004;14562095;14562106;15020711;15190065;15247235;16864574;17330950;17563356;18407956;19779198;20489023;20702584;22966204;23749301;24374639;30516470;32597660;33481703;33491328;34965436;9169872;9931424", "class_list": "", "function": "Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1. The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0H3", "ec_number_list": "", "go_molecular_function": "GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:2000397 positive regulation of ubiquitin-dependent endocytosis;GO:0000209 protein polyubiquitination;GO:0006513 protein monoubiquitination;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q03758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03768-1", "uniprot_id": "GIR2_YEAST", "mass": 31031.0, "length": 265, "protein_name": "Protein GIR2", "gene_name": "GIR2", "organism": "Yeast", "refseq_name": "Gir2p", "refseq_ac": "NP_010436", "gene_names_uniprotkb": "GIR2; DFRP2; YD8358.08", "gene_names_refseq": "GIR2", "protein_names_uniprotkb": "Protein GIR2; DRG family-regulatory protein 2; Genetically interacts with ribosomal genes protein 2", "protein_names_refseq": "Gir2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR152W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;15676025;17322287;19448108;24374639;33229814;33481703;33491328;9169867", "class_list": "", "function": "Acts as a negative regulator of the GCN2 kinase activity by disrupting the GCN1-GCN2 interaction in amino acid-starved cells (PubMed:19448108)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VSD4", "ec_number_list": "", "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0031333 negative regulation of protein-containing complex assembly;GO:0034198 cellular response to amino acid starvation;GO:0002181 cytoplasmic translation;GO:1903833 positive regulation of cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q03768-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03769-1", "uniprot_id": "ENT5_YEAST", "mass": 47321.0, "length": 411, "protein_name": "Epsin-5", "gene_name": "ENT5", "organism": "Yeast", "refseq_name": "Ent5p", "refseq_ac": "NP_010437", "gene_names_uniprotkb": "ENT5", "gene_names_refseq": "ENT5", "protein_names_uniprotkb": "Epsin-5", "protein_names_refseq": "Ent5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR153C); (R-SCE-8856825)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "12483220;14562106;15107463;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22814378;23749301;24374639;30516470;33481703;33491328;9169867", "class_list": "", "function": "Involved in the recruitment of clathrin to the Golgi network and endosomes to form clathrin coated vesicles. Plays a role in the trafficking of clathrin between the Golgi network and endosomes. Binds to membranes enriched in phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) and, in association with VPS27, is involved in protein sorting at the multivesicular body (MVB)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VSD5;Q6Q5U2", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0030276 clathrin binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0006895 Golgi to endosome transport;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q03769-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03771-1", "uniprot_id": "ACL4_YEAST", "mass": 42943.0, "length": 387, "protein_name": "Assembly chaperone of RPL4", "gene_name": "ACL4", "organism": "Yeast", "refseq_name": "Acl4p", "refseq_ac": "NP_010445", "gene_names_uniprotkb": "ACL4", "gene_names_refseq": "ACL4", "protein_names_uniprotkb": "Assembly chaperone of RPL4", "protein_names_refseq": "Acl4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR161W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;18407956;19779198;22814378;24374639;25936803;33491328;9169867", "class_list": "", "function": "Acts as a chaperone for the L4 ribosomal subunit encoded by RPL4A and PRPL4B, required for hierarchical ribosome assembly. Shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSE1", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0030943 mitochondrion targeting sequence binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0042273 ribosomal large subunit biogenesis;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03771-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03772-1", "uniprot_id": "CWC15_YEAST", "mass": 19935.0, "length": 175, "protein_name": "Pre-mRNA-splicing factor CWC15", "gene_name": "CWC15", "organism": "Yeast", "refseq_name": "U2-type spliceosomal complex subunit CWC15", "refseq_ac": "NP_010447", "gene_names_uniprotkb": "CWC15; YD8358.17", "gene_names_refseq": "CWC15", "protein_names_uniprotkb": "Pre-mRNA-splicing factor CWC15; Complexed with CEF1 protein 15", "protein_names_refseq": "U2-type spliceosomal complex subunit CWC15", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR163W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11884590;17322287;18407956;24374639;33481703;33491328;33502312;9169867", "class_list": "", "function": "Involved in pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSE3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03772-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03774-1", "uniprot_id": "TRM82_YEAST", "mass": 50488.0, "length": 444, "protein_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82", "gene_name": "TRM82", "organism": "Yeast", "refseq_name": "Trm82p", "refseq_ac": "NP_010449", "gene_names_uniprotkb": "TRM82; YD8358.19", "gene_names_refseq": "TRM82", "protein_names_uniprotkb": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Transfer RNA methyltransferase 82", "protein_names_refseq": "Trm82p", "tax_id": 559292, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694); microcephaly, growth deficiency, seizures, and brain malformations (Disease Ontology:DOID:0081051)", "pathway": " (sce:YDR165W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12403464;14562095;14562106;15811913;16387656;17382321;17563356;18184583;18407956;21126336;21177495;22814378;23749301;24374639;26416026;32597660;33481703;33491328;9169867", "class_list": "", "function": "Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSE5", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex;GO:0106143 tRNA (m7G46) methyltransferase complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0106004 tRNA (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q03774-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03778-1", "uniprot_id": "RIFK_YEAST", "mass": 24537.0, "length": 218, "protein_name": "Riboflavin kinase", "gene_name": "FMN1", "organism": "Yeast", "refseq_name": "riboflavin kinase", "refseq_ac": "NP_010522", "gene_names_uniprotkb": "FMN1; YD8419.03C", "gene_names_refseq": "FMN1", "protein_names_uniprotkb": "Riboflavin kinase; 2.7.1.26; Flavin mononucleotide kinase 1", "protein_names_refseq": "riboflavin kinase", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDR236C); (R-SCE-196843)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10887197;14562106;17322287;18407956;24374639;33481703;33491328;9169867", "class_list": "", "function": "Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSL7", "ec_number_list": "2.7.1.26", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008531 riboflavin kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0009231 riboflavin biosynthetic process;GO:0009398 FMN biosynthetic process;GO:0006771 riboflavin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03778-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03785-1", "uniprot_id": "VHS1_YEAST", "mass": 52136.0, "length": 461, "protein_name": "Serine/threonine-protein kinase VHS1", "gene_name": "VHS1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase VHS1", "refseq_ac": "NP_010533", "gene_names_uniprotkb": "VHS1; YD8419.14", "gene_names_refseq": "VHS1", "protein_names_uniprotkb": "Serine/threonine-protein kinase VHS1; 2.7.11.1; Viable in a HAL3 SIT4 background protein 1", "protein_names_refseq": "putative serine/threonine protein kinase VHS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR247W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12518319;14562095;14562106;20489023;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Probable serine/threonine protein kinase involved in the G1-S transition., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0032880 regulation of protein localization;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03785-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03833-1", "uniprot_id": "GIS1_YEAST", "mass": 99481.0, "length": 894, "protein_name": "Transcriptional activator/repressor GIS1", "gene_name": "GIS1", "organism": "Yeast", "refseq_name": "histone demethylase GIS1", "refseq_ac": "NP_010381", "gene_names_uniprotkb": "GIS1; YD8557.01", "gene_names_refseq": "GIS1", "protein_names_uniprotkb": "Transcriptional activator/repressor GIS1", "protein_names_refseq": "histone demethylase GIS1", "tax_id": 559292, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); withdrawal disorder (Disease Ontology:DOID:0060001); autosomal dominant intellectual developmental disorder 65 (Disease Ontology:DOID:0061038); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); head and neck cancer (Disease Ontology:DOID:11934); autistic disorder (Disease Ontology:DOID:12849); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); colorectal cancer (Disease Ontology:DOID:9256); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (sce:YDR096W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10523651;10628841;10835355;12799368;14562095;14562106;17330950;17563356;18407956;19779198;20702584;21126336;21177495;22218487;23273919;23749301;24374639;32597660;33229814;33481703;33491328;9169867;9171100", "class_list": "", "function": "Transcription factor involved in the regulation of gene expression upon nutrient starvation. Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region. Can act as a transcriptional activator (e.g. of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e.g. of pyrophosphate phosphatase DPP1). GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VS81", "ec_number_list": "", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0032454 histone H3K9 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q03833-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03855-1", "uniprot_id": "YD11B_YEAST", "mass": 198595.0, "length": 1755, "protein_name": "Transposon Ty1-DR1 Gag-Pol polyprotein", "gene_name": "TY1B-DR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058140", "gene_names_uniprotkb": "TY1B-DR1; YD8557.06c; YDRCTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-DR1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR098C-B)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15665377;16093660;16093680;24374639;2837641;9169867;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VS84", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q03855-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03868-1", "uniprot_id": "SPO71_YEAST", "mass": 145181.0, "length": 1245, "protein_name": "Prospore membrane adapter protein SPO71", "gene_name": "SPO71", "organism": "Yeast", "refseq_name": "Spo71p", "refseq_ac": "NP_010389", "gene_names_uniprotkb": "SPO71; YD8557.13c", "gene_names_refseq": "SPO71", "protein_names_uniprotkb": "Prospore membrane adapter protein SPO71; Sporulation-specific protein 71", "protein_names_refseq": "Spo71p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR104C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18407956;19779198;22611022;23749301;24036347;24374639;30018089;32597660;33229814;33481703;33491328;9169867;9784122", "class_list": "", "function": "Recruits the lipid transfer protein VPS13 to the prospore membrane during sporulation, thereby aiding prospore membrane formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VS90", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005628 prospore membrane", "go_biological_process": "GO:1902657 protein localization to prospore membrane;GO:0032120 ascospore-type prospore membrane formation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q03868-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03897-1", "uniprot_id": "WDR59_YEAST", "mass": 130946.0, "length": 1148, "protein_name": "Maintenance of telomere capping protein 5", "gene_name": "MTC5", "organism": "Yeast", "refseq_name": "Mtc5p", "refseq_ac": "NP_010413", "gene_names_uniprotkb": "MTC5; SEA3", "gene_names_refseq": "MTC5; SEA3", "protein_names_uniprotkb": "Maintenance of telomere capping protein 5; SEH-associated protein 3", "protein_names_refseq": "Mtc5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR128W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562095;14562106;17563356;18407956;18845848;19779198;20489023;21126336;21454883;23749301;24374639;30516470;32597660;33481703;33491328;9169867", "class_list": "", "function": "Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in telomere capping., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSB4", "ec_number_list": "", "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005774 vacuolar membrane;GO:0000329 fungal-type vacuole membrane;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0015031 protein transport;GO:0034198 cellular response to amino acid starvation;GO:1903432 regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q03897-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03920-1", "uniprot_id": "MTQ2_YEAST", "mass": 24973.0, "length": 221, "protein_name": "eRF1 methyltransferase catalytic subunit MTQ2", "gene_name": "MTQ2", "organism": "Yeast", "refseq_name": "S-adenosylmethionine-dependent methyltransferase", "refseq_ac": "NP_010424", "gene_names_uniprotkb": "MTQ2; MTC6", "gene_names_refseq": "MTQ2", "protein_names_uniprotkb": "eRF1 methyltransferase catalytic subunit MTQ2; 2.1.1.297; N(5)-glutamine methyltransferase MTQ2; eRF1 MTase catalytic subunit MTQ2", "protein_names_refseq": "S-adenosylmethionine-dependent methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR140W); (R-SCE-156581); (R-SCE-72764)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "14562095;14562106;15509572;15899842;16321977;17008308;17322287;24374639;9169867", "class_list": "", "function": "Methylates eRF1 on 'Gln-182' using S-adenosyl L-methionine as methyl donor. eRF1 needs to be complexed to eRF3 in its GTP-bound form to be efficiently methylated., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSC3", "ec_number_list": "3.6.5.-;2.1.1.297", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008276 protein methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0102559 peptide chain release factor N(5)-glutamine methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005840 ribosome;GO:0015934 large ribosomal subunit;GO:0035657 eRF1 methyltransferase complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0042273 ribosomal large subunit biogenesis;GO:0060566 positive regulation of termination of DNA-templated transcription;GO:0018364 peptidyl-glutamine methylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03920-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03944-1", "uniprot_id": "VPS64_YEAST", "mass": 67284.0, "length": 604, "protein_name": "Vacuolar protein sorting-associated protein 64", "gene_name": "VPS64", "organism": "Yeast", "refseq_name": "Vps64p", "refseq_ac": "NP_010486", "gene_names_uniprotkb": "VPS64; FAR9; YD9346.10C", "gene_names_refseq": "FAR9; VPS64", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 64; Factor arrest protein 9", "protein_names_refseq": "Vps64p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR200C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12134085;12514182;12588993;14562095;14562106;17287358;18407956;21126336;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Participates in the control of the reentry into the cell cycle following pheromone treatment. Involved in vacuolar protein sorting., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VSI2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0031929 TOR signaling;GO:0071444 cellular response to pheromone;GO:0006623 protein targeting to vacuole;GO:0000321 re-entry into mitotic cell cycle after pheromone arrest", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q03944-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03973-1", "uniprot_id": "HMO1_YEAST", "mass": 27544.0, "length": 246, "protein_name": "High mobility group protein 1", "gene_name": "HMO1", "organism": "Yeast", "refseq_name": "Hmo1p", "refseq_ac": "NP_010459", "gene_names_uniprotkb": "HMO1; HSM2; YD9395.07", "gene_names_refseq": "HMO1; HSM2", "protein_names_uniprotkb": "High mobility group protein 1; High spontaneous mutagenesis protein 2", "protein_names_refseq": "Hmo1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR174W); (R-SCE-140342); (R-SCE-163282); (R-SCE-9837999)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10049913;12374750;12509247;14562095;14562106;17322287;19684113;24374639;32597660;33481703;33491328;8969238;9169867", "class_list": "", "function": "DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSF6", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003690 double-stranded DNA binding;GO:0000400 four-way junction DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006338 chromatin remodeling;GO:0006325 chromatin organization;GO:0030261 chromosome condensation;GO:0044804 nucleophagy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q03973-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q03981-1", "uniprot_id": "CSN9_YEAST", "mass": 19476.0, "length": 162, "protein_name": "COP9 signalosome complex subunit 9", "gene_name": "CSN9", "organism": "Yeast", "refseq_name": "Csn9p", "refseq_ac": "NP_010464", "gene_names_uniprotkb": "CSN9", "gene_names_refseq": "CSN9", "protein_names_uniprotkb": "COP9 signalosome complex subunit 9", "protein_names_refseq": "Csn9p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR179C); (R-SCE-156827); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11805826;12186635;12446563;12672462;14562095;14562106;17322287;24374639;9169867", "class_list": "", "function": "Component of the COP9 signalosome (CSN) complex that acts as a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSG1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0008180 COP9 signalosome;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0000338 protein deneddylation;GO:0071444 cellular response to pheromone;GO:2000434 regulation of protein neddylation;GO:0000747 conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03981-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04013-1", "uniprot_id": "YHM2_YEAST", "mass": 34185.0, "length": 314, "protein_name": "Citrate/oxoglutarate carrier protein", "gene_name": "YHM2", "organism": "Yeast", "refseq_name": "Yhm2p", "refseq_ac": "NP_013968", "gene_names_uniprotkb": "YHM2; YM9408.03", "gene_names_refseq": "YHM2", "protein_names_uniprotkb": "Citrate/oxoglutarate carrier protein; Coc1p; Mitochondrial DNA replication protein YHM2", "protein_names_refseq": "Yhm2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR241W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;14576278;20371607;24374639;33481703;33491328;9169872;9742088", "class_list": "", "function": "Mitochondrial antiporter which catalyzes the transport of citrate and oxoglutarate across the membrane. Also shows specificity for oxaloacetate, and to a lesser extent succinate and fumarate. Transports isocitrate, cis-aconitate and L-malate with very low efficiency. Does not show uniporter activity. Helps to maintain normal citrate levels and NADPH/NADP(+) ratios under conditions of oxidative stress. In addition, associates with the mitochondrial nucleoid and binds DNA in vitro, although the relevance of these data in vivo is unclear., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W067", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0180056 citrate:2-oxoglutarate antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0015742 alpha-ketoglutarate transport;GO:0006843 mitochondrial citrate transmembrane transport;GO:0006842 tricarboxylic acid transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q04013-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04082-1", "uniprot_id": "GPI19_YEAST", "mass": 16090.0, "length": 140, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19", "gene_name": "GPI19", "organism": "Yeast", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase GPI19", "refseq_ac": "NP_010725", "gene_names_uniprotkb": "GPI19; D9461.23", "gene_names_refseq": "GPI19", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19; 2.4.1.198; GPI-GlcNAc transferase complex subunit GPI19; GPI-GnT subunit GPI19", "protein_names_refseq": "phosphatidylinositol N-acetylglucosaminyltransferase GPI19", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 55 (Disease Ontology:DOID:0080283)", "pathway": " (sce:YDR437W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562095;14562106;16278447;24374639;9169867", "class_list": "", "function": "Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Involved in cell wall biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT64", "ec_number_list": "2.4.1.198", "go_molecular_function": "GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04082-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04089-1", "uniprot_id": "DOT1_YEAST", "mass": 66201.0, "length": 582, "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-79 specific", "gene_name": "DOT1", "organism": "Yeast", "refseq_name": "histone methyltransferase DOT1", "refseq_ac": "NP_010728", "gene_names_uniprotkb": "DOT1; D9461.26; KMT4; PCH1", "gene_names_refseq": "DOT1; KMT4; PCH1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase, H3 lysine-79 specific; 2.1.1.360; Disrupter of telomere silencing protein 1; H3-K79-HMTase; Histone H3-K79 methyltransferase; Lysine N-methyltransferase 4; ScDOT1", "protein_names_refseq": "histone methyltransferase DOT1", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); Nil-Deshwar neurodevelopmental syndrome (Disease Ontology:DOID:0070652); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); leukemia (Disease Ontology:DOID:1240); acute biphenotypic leukemia (Disease Ontology:DOID:9953)", "pathway": " (sce:YDR440W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11029058;12080090;12086673;12097318;12152067;12167634;12574507;14562106;15292170;15632126;16166626;18407956;19684113;19779198;21084562;23749301;24374639;32597660;33334889;33491328;35183557;38270553;9169867;9755194", "class_list": "", "function": "Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT67", "ec_number_list": "2.1.1.360", "go_molecular_function": "GO:0003677 DNA binding;GO:0042393 histone binding;GO:0031151 histone H3K79 methyltransferase activity;GO:0140956 histone H3K79 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0000786 nucleosome", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0031509 subtelomeric heterochromatin formation;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q04089-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04110-1", "uniprot_id": "ECM11_YEAST", "mass": 34113.0, "length": 302, "protein_name": "Protein ECM11", "gene_name": "ECM11", "organism": "Yeast", "refseq_name": "Ecm11p", "refseq_ac": "NP_010734", "gene_names_uniprotkb": "ECM11; D9461.31", "gene_names_refseq": "ECM11", "protein_names_uniprotkb": "Protein ECM11; Extracellular mutant protein 11", "protein_names_refseq": "Ecm11p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR446W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10653153;11678331;24374639;33481703;33502312;9169867;9335584", "class_list": "", "function": "May be involved in cell wall organization and biogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT71", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007130 synaptonemal complex assembly;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination;GO:1990414 replication-born double-strand break repair via sister chromatid exchange;GO:0070193 synaptonemal complex organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04110-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04119-1", "uniprot_id": "PPN1_YEAST", "mass": 78344.0, "length": 674, "protein_name": "Endopolyphosphatase", "gene_name": "PPN1", "organism": "Yeast", "refseq_name": "endopolyphosphatase", "refseq_ac": "NP_010740", "gene_names_uniprotkb": "PPN1; D9461.37; PHM5", "gene_names_refseq": "PHM5; PPN1", "protein_names_uniprotkb": "Endopolyphosphatase; 3.6.1.-; 3.6.1.10; 3.6.1.11; Deoxyadenosine triphosphate phosphohydrolase; Exopolyphosphatase; Phosphate metabolism protein 5; dATP phosphohydrolase", "protein_names_refseq": "endopolyphosphatase", "tax_id": 559292, "disease": "Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (sce:YDR452W); (R-SCE-9840310)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "11102525;11447286;11566881;11788821;14562095;14562106;15086787;15170373;15342119;15792812;17009950;18407956;24374639;25742176;28302909;31175919;8900207;9169867", "class_list": "", "function": "Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths. Has both exopolyphosphatase and endopolyphosphatase activities at different ratios depending on divalent cations by cleaving phosphate from the chain end and by fragmenting long-chain polymers into shorter ones, respectively. The limited digestion products are 1 and 3 P(i) residues (PubMed:11102525, PubMed:11447286, PubMed:15170373, PubMed:15342119, PubMed:15792812, PubMed:31175919, PubMed:8900207, Ref.16). Also releases phosphate from dATP. dATP phosphohydrolase activity is about 7-fold lower than the exopolyphosphatase activity (Ref.16)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VT77", "ec_number_list": "3.6.1.11;3.6.1.10;3.6.1.-;3.6.1.52;3.6.1.60", "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0046872 metal ion binding;GO:0004309 exopolyphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006797 polyphosphate metabolic process;GO:0006798 polyphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q04119-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04120-1", "uniprot_id": "TSA2_YEAST", "mass": 21615.0, "length": 196, "protein_name": "Peroxiredoxin TSA2", "gene_name": "TSA2", "organism": "Yeast", "refseq_name": "thioredoxin peroxidase TSA2", "refseq_ac": "NP_010741", "gene_names_uniprotkb": "TSA2; D9461.38", "gene_names_refseq": "TSA2", "protein_names_uniprotkb": "Peroxiredoxin TSA2; 1.11.1.24; Cytoplasmic thiol peroxidase 2; Prx; TPx type Ib; Thiol-specific antioxidant protein 2; Thioredoxin peroxidase type Ib; Thioredoxin-dependent peroxiredoxin TSA2; cTPx 2", "protein_names_refseq": "thioredoxin peroxidase TSA2", "tax_id": 559292, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autosomal recessive spinocerebellar ataxia 32 (Disease Ontology:DOID:0070413); glucose intolerance (Disease Ontology:DOID:10603); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YDR453C); (R-SCE-5628897); (R-SCE-9818027)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10681558;11741925;14562106;15163410;15210711;24374639;26894543;9169867;9888818", "class_list": "", "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (PubMed:10681558, PubMed:11741925, PubMed:15210711). Can act alternatively as peroxidase and molecular chaperone. Oxidative stress and heat shock exposure cause a reversible shift of the protein structure from low MW species to high MW complexes, triggering a peroxidase-to-chaperone functional switch. The chaperone function of the protein enhances resistance to heat shock (PubMed:15163410)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT78", "ec_number_list": "1.11.1.24;1.11.1.9;1.8.98.2", "go_molecular_function": "GO:0051920 peroxiredoxin activity;GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0034605 cellular response to heat;GO:0050821 protein stabilization;GO:0034599 cellular response to oxidative stress;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q04120-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04121-1", "uniprot_id": "NHX1_YEAST", "mass": 70148.0, "length": 633, "protein_name": "Endosomal/prevacuolar sodium/hydrogen exchanger", "gene_name": "NHX1", "organism": "Yeast", "refseq_name": "bifunctional K:H/Na:H antiporter NHX1", "refseq_ac": "NP_010744", "gene_names_uniprotkb": "NHX1; D9461.40; NHA2; VPL27; VPS44", "gene_names_refseq": "NHA2; NHX1; VPL27; VPS44", "protein_names_uniprotkb": "Endosomal/prevacuolar sodium/hydrogen exchanger; Endosomal/prevacuolar Na(+)/H(+) exchanger; Vacuolar protein sorting-associated protein 44", "protein_names_refseq": "bifunctional K:H/Na:H antiporter NHX1", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Christianson syndrome (Disease Ontology:DOID:0060825); X-linked intellectual developmental disorder 108 (Disease Ontology:DOID:0111844); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (sce:YDR456W); (R-SCE-425986)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10589731;10998367;11036065;11102523;14562106;14610088;1493335;15635088;15659172;15665377;16671892;17543551;17588950;18378800;18407956;18799619;19779198;20702584;23749301;24374639;32597660;33481703;33491328;9169867;9334180;9507001;9694857", "class_list": "", "function": "Endosomal/prevacuolar electroneutral Na(+)/H(+) exchanger which mediates intracellular sequestration of Na(+) cations, regulates vacuolar pH and contributes to osmotolerance following sudden exposure to hyperosmotic media. Also contributes to the postdiauxic/stationary phase resistance to osmotic stress and allows for the continued growth of cells until the acquired osmotolerance response can occur. Involved in hygromycin resistance probably through its influence on the electrochemical proton gradient affecting secondarily the entrance of hygromycin. Mediates pH-dependent vesicle trafficking out of the endosome. Contributes to K(+) sequestration and homeostasis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VT80", "ec_number_list": "", "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005770 late endosome;GO:0010008 endosome membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0030003 intracellular monoatomic cation homeostasis;GO:0071805 potassium ion transmembrane transport;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q04121-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04175-1", "uniprot_id": "SXM1_YEAST", "mass": 108405.0, "length": 944, "protein_name": "Importin beta SMX1", "gene_name": "SXM1", "organism": "Yeast", "refseq_name": "Sxm1p", "refseq_ac": "NP_010683", "gene_names_uniprotkb": "SXM1; KAP108", "gene_names_refseq": "KAP108; SXM1", "protein_names_uniprotkb": "Importin beta SMX1; Suppressor of mRNA export mutant protein 1; karyopherin-108", "protein_names_refseq": "Sxm1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR395W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12684370;14562095;14562106;15004228;15769879;16507575;18407956;19795423;19823750;24374639;33481703;33491328;9169867;9238021;9412461;9817748;9891088", "class_list": "", "function": "Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of ribosomal proteins (RPL11, RPL16, RPL25, RPL31A), the poly(A)-binding protein PAB1, the HO endonuclease or the tRNA and snRNA chaperone LHP1. Indirectly involved in nuclear mRNA export through its PAB1 nuclear import activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT29", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q04175-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04178-1", "uniprot_id": "HPRT_YEAST", "mass": 25191.0, "length": 221, "protein_name": "Hypoxanthine-guanine phosphoribosyltransferase", "gene_name": "HPT1", "organism": "Yeast", "refseq_name": "hypoxanthine phosphoribosyltransferase", "refseq_ac": "NP_010687", "gene_names_uniprotkb": "HPT1; BRA6; D9509.18", "gene_names_refseq": "BRA6; HPT1", "protein_names_uniprotkb": "Hypoxanthine-guanine phosphoribosyltransferase; 2.4.2.8; Bypass of repression by adenine protein 6; HGPRTase; HGPRT", "protein_names_refseq": "hypoxanthine phosphoribosyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR399W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11035032;14562095;14562106;18245832;22814378;23749301;24374639;33481703;33491328;371963;6170313;6392474;7035445;9169867;9335580", "class_list": "", "function": "Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT32", "ec_number_list": "2.4.2.8", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0004422 hypoxanthine phosphoribosyltransferase activity;GO:0052657 guanine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032264 IMP salvage;GO:0006166 purine ribonucleoside salvage;GO:0046100 hypoxanthine metabolic process;GO:0032263 GMP salvage;GO:0032265 XMP salvage", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q04178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04179-1", "uniprot_id": "URH1_YEAST", "mass": 37960.0, "length": 340, "protein_name": "Uridine nucleosidase", "gene_name": "URH1", "organism": "Yeast", "refseq_name": "trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase", "refseq_ac": "NP_010688", "gene_names_uniprotkb": "URH1; D9509.19", "gene_names_refseq": "URH1", "protein_names_uniprotkb": "Uridine nucleosidase; 3.2.2.3; Uridine ribohydrolase", "protein_names_refseq": "trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR400W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12111094;12748633;14562095;237897;24374639;9169867", "class_list": "", "function": "Also acts on cytidine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT33", "ec_number_list": "3.2.2.3", "go_molecular_function": "GO:0050263 ribosylpyrimidine nucleosidase activity;GO:0008477 purine nucleosidase activity;GO:0045437 uridine nucleosidase activity;GO:0070635 nicotinamide riboside hydrolase activity;GO:0070636 nicotinic acid riboside hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008655 pyrimidine-containing compound salvage;GO:0006218 uridine catabolic process;GO:0046135 pyrimidine nucleoside catabolic process;GO:0019358 nicotinate nucleotide salvage;GO:0006152 purine nucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04179-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04195-1", "uniprot_id": "SIZ1_YEAST", "mass": 100796.0, "length": 904, "protein_name": "E3 SUMO-protein ligase SIZ1", "gene_name": "SIZ1", "organism": "Yeast", "refseq_name": "SUMO ligase SIZ1", "refseq_ac": "NP_010697", "gene_names_uniprotkb": "SIZ1; ULL1", "gene_names_refseq": "SIZ1; ULL1", "protein_names_uniprotkb": "E3 SUMO-protein ligase SIZ1; 2.3.2.-; E3 SUMO-protein transferase SIZ2; SAP and Miz-finger domain-containing protein 1; Ubiquitin-like protein ligase 1", "protein_names_refseq": "SUMO ligase SIZ1", "tax_id": 559292, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (sce:YDR409W); (R-SCE-3232118); (R-SCE-4085377); (R-SCE-4551638)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "11333221;11572779;11577116;11587849;12226657;12761287;14562095;14562106;15166219;16109721;17563356;18407956;19779198;19795423;19823750;23749301;24374639;32597660;33229814;33481703;33491328;34965436;8212897;9169867", "class_list": "", "function": "Acts as an E3 ligase mediating SUMO/Smt3 attachment to septins and PCNA. May be involved in chromosome maintenance., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 34, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VT41;Q06762;Q7LIJ4", "ec_number_list": "2.3.2.-", "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0005940 septin ring;GO:0005634 nucleus;GO:0000785 chromatin;GO:0005935 cellular bud neck", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016925 protein sumoylation;GO:0031397 negative regulation of protein ubiquitination;GO:1990683 DNA double-strand break attachment to nuclear envelope", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q04195-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04214-1", "uniprot_id": "YM13B_YEAST", "mass": 198899.0, "length": 1755, "protein_name": "Transposon Ty1-MR1 Gag-Pol polyprotein", "gene_name": "TY1B-MR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_013759", "gene_names_uniprotkb": "TY1B-MR1; YM9532.10C; YMRCTy1-3 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-MR1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR045C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16093660;16093680;17287358;17330950;18407956;19779198;21177495;24374639;9169872;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VZM0", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q04214-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04235-1", "uniprot_id": "TYW2_YEAST", "mass": 52726.0, "length": 462, "protein_name": "tRNA wybutosine-synthesizing protein 2", "gene_name": "TRM12", "organism": "Yeast", "refseq_name": "tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase", "refseq_ac": "NP_013709", "gene_names_uniprotkb": "TRM12; TYW2; YM9571.14", "gene_names_refseq": "TRM12; TYW2", "protein_names_uniprotkb": "tRNA wybutosine-synthesizing protein 2; 2.5.1.114; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW-synthesizing protein 2", "protein_names_refseq": "tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YML005W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;16005430;16642040;17150819;24374639;33491328;9169872", "class_list": "", "function": "S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZH0", "ec_number_list": "2.5.1.114", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0102522 tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04235-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04264-1", "uniprot_id": "PDS5_YEAST", "mass": 147041.0, "length": 1277, "protein_name": "Sister chromatid cohesion protein PDS5", "gene_name": "PDS5", "organism": "Yeast", "refseq_name": "sister chromatid cohesion factor PDS5", "refseq_ac": "NP_013793", "gene_names_uniprotkb": "PDS5; YM9582.01C; YM9916.15C", "gene_names_refseq": "PDS5", "protein_names_uniprotkb": "Sister chromatid cohesion protein PDS5; Precocious dissociation of sisters protein 5", "protein_names_refseq": "sister chromatid cohesion factor PDS5", "tax_id": 559292, "disease": "Cornelia de Lange syndrome (Disease Ontology:DOID:11725)", "pathway": " (sce:YMR076C); (R-SCE-2468052); (R-SCE-2500257)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11062262;11137006;11864574;14562095;14562106;17563356;18407956;19779198;20702584;23749301;24374639;33491328;9169872", "class_list": "", "function": "Essential for the establishment and maintenance of sister chromatid cohesion at centromere proximal and distal regions during S phase. Also required for chromosomal condensation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZQ0;Q04780", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0140670 cohesin unloader activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0035808 meiotic recombination initiation complex", "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0007076 mitotic chromosome condensation;GO:0007130 synaptonemal complex assembly;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q04264-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04307-1", "uniprot_id": "RPC10_YEAST", "mass": 12513.0, "length": 110, "protein_name": "DNA-directed RNA polymerase III subunit RPC10", "gene_name": "RPC11", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase III core subunit RPC11", "refseq_ac": "NP_010330", "gene_names_uniprotkb": "RPC11; YD9609.01C", "gene_names_refseq": "RPC11", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC10; DNA-directed RNA polymerases III 12.5 kDa polypeptide; RNA polymerase III subunit C10; RNA polymerase III subunit C11", "protein_names_refseq": "DNA-directed RNA polymerase III core subunit RPC11", "tax_id": 559292, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 21 (Disease Ontology:DOID:0070407)", "pathway": " (sce:YDR045C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10384303;15905473;16362040;17322287;24374639;33481703;9169867;9869639", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Involved in Pol III transcription reinitiation and RNA cleavage during transcription termination., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS33;Q2VQW5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04307-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04344-1", "uniprot_id": "HNT1_YEAST", "mass": 17680.0, "length": 158, "protein_name": "Adenosine 5'-monophosphoramidase HNT1", "gene_name": "HNT1", "organism": "Yeast", "refseq_name": "adenosine 5'-monophosphoramidase", "refseq_ac": "NP_010158", "gene_names_uniprotkb": "HNT1; HIT1", "gene_names_refseq": "HNT1", "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HNT1; 3.-.-.-; HINT; Histidine triad nucleotide-binding protein HNT1; Hit family protein 1", "protein_names_refseq": "adenosine 5'-monophosphoramidase", "tax_id": 559292, "disease": "Gamstorp-Wohlfart syndrome (Disease Ontology:DOID:0050526)", "pathway": " (sce:YDL125C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10958787;11805111;14562106;1472710;1860879;22842922;24374639;31692084;32475637;33184379;33481703;33491328;9169867", "class_list": "", "function": "Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (PubMed:11805111). Plays a role in the regulation of kinase KIN28 function (PubMed:10958787). Essential for growth on galactose media at elevated temperatures (PubMed:11805111)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRM5", "ec_number_list": "3.-.-.-", "go_molecular_function": "GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q04344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04359-1", "uniprot_id": "SPO20_YEAST", "mass": 46621.0, "length": 397, "protein_name": "Sporulation-specific protein 20", "gene_name": "SPO20", "organism": "Yeast", "refseq_name": "Spo20p", "refseq_ac": "NP_013730", "gene_names_uniprotkb": "SPO20; YM9711.05", "gene_names_refseq": "DBI9; SPO20", "protein_names_uniprotkb": "Sporulation-specific protein 20", "protein_names_refseq": "Spo20p", "tax_id": 559292, "disease": "CEDNIK syndrome (Disease Ontology:DOID:0060337); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); developmental and epileptic encephalopathy 117 (Disease Ontology:DOID:0110683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Down syndrome (Disease Ontology:DOID:14250); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YMR017W); (R-SCE-199992); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013406)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10924463;14742704;17322287;18407956;24374639;33229814;9096343;9169872;9425151", "class_list": "", "function": "Required to maintain the prospore membrane to the nucleus during sporulation in order to capture the daughter nuclei and form the spores. Mediates the fusion of exocytic vesicles with the plasma membrane during sporulation through its interactions with the t-SNARE SSO1 and v-SNARE SNC2., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VZJ1;Q6B245", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019905 syntaxin binding;GO:0070300 phosphatidic acid binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0031201 SNARE complex;GO:0005628 prospore membrane", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0006906 vesicle fusion;GO:0031321 ascospore-type prospore assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q04359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04364-1", "uniprot_id": "PEX9_YEAST", "mass": 59065.0, "length": 514, "protein_name": "Peroxisomal targeting signal receptor 9", "gene_name": "PEX9", "organism": "Yeast", "refseq_name": "Pex9p", "refseq_ac": "NP_013731", "gene_names_uniprotkb": "PEX9; YM9711.06", "gene_names_refseq": "PEX9", "protein_names_uniprotkb": "Peroxisomal targeting signal receptor 9; PTS1 receptor 9; PTS1R 9; Peroxin-9", "protein_names_refseq": "Pex9p", "tax_id": 559292, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 2A (Disease Ontology:DOID:0080477); peroxisome biogenesis disorder 2B (Disease Ontology:DOID:0080622); rhizomelic chondrodysplasia punctata type 5 (Disease Ontology:DOID:0110854)", "pathway": " (sce:YMR018W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11283351;11463335;17322287;24374639;27663510;27678487;9169872", "class_list": "", "function": "Peroxisomal import receptor that mediates the peroxisomal import of both malate synthases MLS1 and MLS2 in oleate-grown cells (PubMed:27663510, PubMed:27678487). Recognizes the C-terminal peroxisomal targeting signal PTS1 sequence SKL of MLS1 and MLS2, probably via its TPR domains (PubMed:27678487). Interacts with the PTS1-receptor docking protein PEX14 but not with peroxins PEX1, PEX3 through to PEX8, PEX10, PEX11, PEX12, PEX13, PEX15, PEX17, PEX18, PEX19 and PEX21 (PubMed:27678487)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZJ2;Q6B2L0", "ec_number_list": "", "go_molecular_function": "GO:0005052 peroxisome matrix targeting signal-1 binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol", "go_biological_process": "GO:0016558 protein import into peroxisome matrix;GO:0016560 protein import into peroxisome matrix, docking", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04364-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04368-1", "uniprot_id": "CSI1_YEAST", "mass": 34520.0, "length": 295, "protein_name": "Cop9 signalosome-interactor 1", "gene_name": "CSI1", "organism": "Yeast", "refseq_name": "Csi1p", "refseq_ac": "NP_013738", "gene_names_uniprotkb": "CSI1; YM9711.15", "gene_names_refseq": "CSI1", "protein_names_uniprotkb": "Cop9 signalosome-interactor 1", "protein_names_refseq": "Csi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR025W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11805826;12186635;12446563;12672462;24374639;9169872", "class_list": "", "function": "Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZJ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0000338 protein deneddylation;GO:0071444 cellular response to pheromone;GO:2000434 regulation of protein neddylation;GO:0000747 conjugation with cellular fusion;GO:0000754 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04368-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04370-1", "uniprot_id": "PEX12_YEAST", "mass": 45992.0, "length": 399, "protein_name": "Peroxisome assembly protein 12", "gene_name": "PEX12", "organism": "Yeast", "refseq_name": "ubiquitin-protein ligase peroxin 12", "refseq_ac": "NP_013739", "gene_names_uniprotkb": "PEX12; YM9711.16C", "gene_names_refseq": "PAS11; PEX12", "protein_names_uniprotkb": "Peroxisome assembly protein 12; Peroxin-12", "protein_names_refseq": "ubiquitin-protein ligase peroxin 12", "tax_id": 559292, "disease": "peroxisome biogenesis disorder 3A (Disease Ontology:DOID:0080478); peroxisome biogenesis disorder 3B (Disease Ontology:DOID:0081241)", "pathway": " (sce:YMR026C); (R-SCE-9033241); (R-SCE-9603798)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11370741;14562106;17322287;19687296;22471590;24374639;35768507;9090384;9169872", "class_list": "", "function": "Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:11370741, PubMed:19687296, PubMed:22471590, PubMed:35768507, PubMed:9090384). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (PubMed:35768507). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (PubMed:35768507)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZK0;Q6B1L4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0008320 protein transmembrane transporter activity;GO:1990757 ubiquitin ligase activator activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0016558 protein import into peroxisome matrix", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q04370-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04396-1", "uniprot_id": "LPP1_YEAST", "mass": 31586.0, "length": 274, "protein_name": "Lipid phosphate phosphatase 1", "gene_name": "LPP1", "organism": "Yeast", "refseq_name": "phosphatidate phosphatase LPP1", "refseq_ac": "NP_010791", "gene_names_uniprotkb": "LPP1; D9719.9", "gene_names_refseq": "LPP1", "protein_names_uniprotkb": "Lipid phosphate phosphatase 1; 3.1.3.106; 3.1.3.4; 3.6.1.75; Lysophosphatidate phosphatase; Phosphatidate phosphatase", "protein_names_refseq": "phosphatidate phosphatase LPP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR503C); (R-SCE-2029485); (R-SCE-419408); (R-SCE-9845614)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10329682;10685032;12786943;14562095;14562106;17322287;24374639;33491328;9169867;9603941", "class_list": "", "function": "Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA > DGPP > LPA., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTC5", "ec_number_list": "3.1.3.4;3.1.3.106;3.6.1.75", "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0000810 diacylglycerol diphosphate phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q04396-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04409-1", "uniprot_id": "EMI2_YEAST", "mass": 55921.0, "length": 500, "protein_name": "Putative glucokinase-2", "gene_name": "EMI2", "organism": "Yeast", "refseq_name": "putative glucokinase", "refseq_ac": "NP_010804", "gene_names_uniprotkb": "EMI2; D9719.21", "gene_names_refseq": "EMI2", "protein_names_uniprotkb": "Putative glucokinase-2; 2.7.1.2; Early meiotic induction protein 2; GLK-2; Glucose kinase 2", "protein_names_refseq": "putative glucokinase", "tax_id": 559292, "disease": "congenital nonspherocytic hemolytic anemia 5 (Disease Ontology:DOID:0051006); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); retinitis pigmentosa 92 (Disease Ontology:DOID:0061107); retinitis pigmentosa 79 (Disease Ontology:DOID:0061108); familial hyperinsulinemic hypoglycemia 3 (Disease Ontology:DOID:0070216); Charcot-Marie-Tooth disease type 4G (Disease Ontology:DOID:0110196); maturity-onset diabetes of the young type 2 (Disease Ontology:DOID:0111100); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); gestational diabetes (Disease Ontology:DOID:11714); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); hyperinsulinism (Disease Ontology:DOID:2018); anemia (Disease Ontology:DOID:2355); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (sce:YDR516C); (R-SCE-170822); (R-SCE-446205); (R-SCE-6798695); (R-SCE-70171)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "12586695;14562095;14562106;15665377;18407956;19779198;19795423;19823750;24374639;33491328;9169867;9832517", "class_list": "", "function": "Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake (By similarity). Involved in sporulation. Required for the full activation of the early meiotic inducer IME1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTD7", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0005524 ATP binding;GO:0004396 hexokinase activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0019318 hexose metabolic process;GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q04409-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04432-1", "uniprot_id": "HSP31_YEAST", "mass": 25670.0, "length": 237, "protein_name": "Glutathione-independent glyoxalase HSP31", "gene_name": "HSP31", "organism": "Yeast", "refseq_name": "glutathione-independent methylglyoxalase", "refseq_ac": "NP_010822", "gene_names_uniprotkb": "HSP31; D9719.36", "gene_names_refseq": "HSP31", "protein_names_uniprotkb": "Glutathione-independent glyoxalase HSP31; 4.2.1.130; Glyoxalase 3 homolog 1; Heat shock protein 31", "protein_names_refseq": "glutathione-independent methylglyoxalase", "tax_id": 559292, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDR533C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12855764;14562106;14745011;15130476;17322287;17395014;24302734;24374639;24706893;24758716;33491328;9169867", "class_list": "", "function": "Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals (PubMed:24302734). Involved in protection against reactive oxygen species (ROS) (PubMed:17395014). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTF4;E9P8V9", "ec_number_list": "4.2.1.130", "go_molecular_function": "GO:0044183 protein folding chaperone;GO:0019172 glyoxalase III activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0034599 cellular response to oxidative stress;GO:0006457 protein folding;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q04432-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04433-1", "uniprot_id": "FIT1_YEAST", "mass": 52490.0, "length": 528, "protein_name": "Facilitator of iron transport 1", "gene_name": "FIT1", "organism": "Yeast", "refseq_name": "Fit1p", "refseq_ac": "NP_010823", "gene_names_uniprotkb": "FIT1; D9719.37", "gene_names_refseq": "FIT1", "protein_names_uniprotkb": "Facilitator of iron transport 1", "protein_names_refseq": "Fit1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR534C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10383953;11673473;16086015;24374639;9169867;9613572", "class_list": "", "function": "Involved in the uptake of non-siderophore sources of iron and the siderophores ferrioxamine B and ferrichrome. Has a role in the retention of iron in the cell wall and periplasmic space., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VTF5", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0015891 siderophore transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04433-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04458-1", "uniprot_id": "HFD1_YEAST", "mass": 59979.0, "length": 532, "protein_name": "Fatty aldehyde dehydrogenase HFD1", "gene_name": "HFD1", "organism": "Yeast", "refseq_name": "hexadecenal dehydrogenase", "refseq_ac": "NP_013828", "gene_names_uniprotkb": "HFD1; YM9718.09C", "gene_names_refseq": "HFD1", "protein_names_uniprotkb": "Fatty aldehyde dehydrogenase HFD1; 1.2.1.3; 1.2.1.64; Hexadecenal dehydrogenase", "protein_names_refseq": "hexadecenal dehydrogenase", "tax_id": 559292, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); arteriosclerosis (Disease Ontology:DOID:2349)", "pathway": " (sce:YMR110C); (R-SCE-211945); (R-SCE-389599); (R-SCE-6798695); (R-SCE-9603798); (R-SCE-9609523); (R-SCE-9696273); (R-SCE-9845614)", "pathway_count": 8, "publication_count": 19, "publication_id_list": "14562095;14562106;14576278;16407407;16689936;17287358;17330950;18407956;19779198;20702584;22633490;23749301;24374639;24868093;27669165;27693056;33481703;33491328;9169872", "class_list": "", "function": "Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). Involved in coenzyme Q (CoQ) biosynthesis, catalyzing the last step in the tyrosine to 4-hydroxybenzoate (4-HB) pathway. Oxidizes 4-hydroxybenzaldehyde (4-Hbz) to 4-HB, the aromatic precursor for coenzyme Q (PubMed:27669165, PubMed:27693056)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZT3", "ec_number_list": "3.6.5.2;3.1.3.48;7.4.2.-;2.3.2.23;2.3.1.51;2.3.1.23;2.3.1.n7;3.1.4.4;7.6.2.1;3.4.11.-;1.2.1.5;3.4.-.-;1.2.1.3;1.2.1.64", "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0018484 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity;GO:0047770 carboxylate reductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005768 endosome", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0006081 aldehyde metabolic process;GO:0046185 aldehyde catabolic process;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q04458-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04461-1", "uniprot_id": "EUC1_YEAST", "mass": 52370.0, "length": 462, "protein_name": "Transcription factor-like protein EUC1", "gene_name": "EUC1", "organism": "Yeast", "refseq_name": "Euc1p", "refseq_ac": "NP_013829", "gene_names_uniprotkb": "EUC1; YM9718.10C", "gene_names_refseq": "EUC1", "protein_names_uniprotkb": "Transcription factor-like protein EUC1; Enriches ubiquitin on chromatin protein 1", "protein_names_refseq": "Euc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR111C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;17563356;18407956;19779198;20702584;21126336;22218487;23749301;24374639;30516470;31015336;32597660;33229814;33481703;33491328;33502312;9169872", "class_list": "", "function": "Transcription factor-like protein that binds to specific DNA motifs called ub-HS-motif associated with several locations where proteins other than histone H2B are ubiquitinated (ub-hotspots) (PubMed:31015336). Ubiquitination at these sites depends on the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 and protein turnover on the CDC48 segregase (PubMed:31015336). UBC9, SIZ1, or SIZ2 sumoylate DNA-bound EUC1 to stabilize its DNA-binding (PubMed:31015336). Sumoylated EUC1 acts a cofactor required for the recruitment of the SLX5/SLX8 STUbL complex via specific contacts between EUC1 and SLX5, as well as an additional SUMO-mediated interaction (PubMed:31015336). SLX5/SLX8 then ubiquitinates EUC1 and presumably other targets at ub-hotspots, and the CDC48/UFD1/NPL4 complex, together with UBX4 and UBX5, removes Lys-48-linked ubiquitinated proteins from chromatin. Ubiquitinated proteins could be either degraded by the proteasome or recycled by deubiquitination (PubMed:31015336). EUC1 itself does not seem to underlie extensive turnover, as it is a very stable protein (PubMed:31015336). EUC1 is able to act as a transcription factor, but its function at ub-hotspots does not seem to depend on this ability (PubMed:31015336). EUC1-mediated ub-hotspots are crucial during stress responses when gene expression control is impaired (PubMed:31015336)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VZT4", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0031503 protein-containing complex localization;GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q04461-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04472-1", "uniprot_id": "MGR3_YEAST", "mass": 58004.0, "length": 501, "protein_name": "Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3", "gene_name": "MGR3", "organism": "Yeast", "refseq_name": "Mgr3p", "refseq_ac": "NP_013833", "gene_names_uniprotkb": "MGR3; FMP24; YM9718.14", "gene_names_refseq": "FMP24; MGR3", "protein_names_uniprotkb": "Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3; Mitochondrial genome-required protein 3", "protein_names_refseq": "Mgr3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR115W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;14576278;18843051;24374639;9169872", "class_list": "", "function": "Component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. Together with MGR1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation. Required for growth of cells lacking the mitochondrial genome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZT8", "ec_number_list": "", "go_molecular_function": "GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031942 i-AAA complex", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0030163 protein catabolic process;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0141164 mitochondrial protein quality control", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04472-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04500-1", "uniprot_id": "UTP14_YEAST", "mass": 103023.0, "length": 899, "protein_name": "U3 small nucleolar RNA-associated protein 14", "gene_name": "UTP14", "organism": "Yeast", "refseq_name": "Utp14p", "refseq_ac": "NP_013617", "gene_names_uniprotkb": "UTP14", "gene_names_refseq": "UTP14", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 14; U three protein 14; U3 snoRNA-associated protein 14", "protein_names_refseq": "Utp14p", "tax_id": 559292, "disease": "", "pathway": " (sce:YML093W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "12068309;14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;30516470;32597660;33229814;33481703;33491328;9169872", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0J2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q04500-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04629-1", "uniprot_id": "SWF1_YEAST", "mass": 39312.0, "length": 336, "protein_name": "Palmitoyltransferase SWF1", "gene_name": "SWF1", "organism": "Yeast", "refseq_name": "palmitoyltransferase SWF1", "refseq_ac": "NP_010411", "gene_names_uniprotkb": "SWF1; PSL10; YD9302.01; YD9727.21", "gene_names_refseq": "PSL10; SWF1", "protein_names_uniprotkb": "Palmitoyltransferase SWF1; 2.3.1.225; Spore wall formation protein 1", "protein_names_refseq": "palmitoyltransferase SWF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR126W); (R-SCE-203615)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15973437;16847258;17322287;24374639;9169867", "class_list": "", "function": "Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs SNC1, SNC2, SYN8 and TLG1, at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSB2;Q03889", "ec_number_list": "1.6.2.4;2.3.1.225", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0032432 actin filament bundle;GO:0030479 actin cortical patch", "go_biological_process": "GO:0042144 vacuole fusion, non-autophagic;GO:0006612 protein targeting to membrane;GO:0030866 cortical actin cytoskeleton organization;GO:0030010 establishment of cell polarity;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04629-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04659-1", "uniprot_id": "CSM3_YEAST", "mass": 36355.0, "length": 317, "protein_name": "Chromosome segregation in meiosis protein 3", "gene_name": "CSM3", "organism": "Yeast", "refseq_name": "Csm3p", "refseq_ac": "NP_013763", "gene_names_uniprotkb": "CSM3; YM9796.01", "gene_names_refseq": "CSM3", "protein_names_uniprotkb": "Chromosome segregation in meiosis protein 3", "protein_names_refseq": "Csm3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR048W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11470404;14562095;14562106;14742714;15282308;15755447;16024805;16219777;16418273;17322287;18407956;24374639;33491328;9169872", "class_list": "", "function": "Forms a fork protection complex (FPC) with TOF1 which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors and protects stalled replication forks against the fork-releasing activity of RRM3 helicase., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZM3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0045132 meiotic chromosome segregation;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0043570 maintenance of DNA repeat elements", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q04659-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04670-1", "uniprot_id": "YM14B_YEAST", "mass": 198555.0, "length": 1755, "protein_name": "Transposon Ty1-MR2 Gag-Pol polyprotein", "gene_name": "TY1B-MR2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_013765", "gene_names_uniprotkb": "TY1B-MR2; YM9796.03C; YMRCTy1-4 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-MR2 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR050C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169872;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VZM5", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04670-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04673-1", "uniprot_id": "SSL1_YEAST", "mass": 52290.0, "length": 461, "protein_name": "General transcription and DNA repair factor IIH subunit SSL1", "gene_name": "SSL1", "organism": "Yeast", "refseq_name": "TFIIH/NER complex subunit SSL1", "refseq_ac": "NP_013105", "gene_names_uniprotkb": "SSL1", "gene_names_refseq": "SSL1", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH subunit SSL1; RNA polymerase II transcription factor B subunit SSL1; Suppressor of stem-loop protein 1; TFB subunit SSL1; TFIIH subunit SSL1", "protein_names_refseq": "TFIIH/NER complex subunit SSL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR005W); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 14, "publication_count": 19, "publication_id_list": "1340463;14500720;14562106;17322287;18407956;20702584;21126336;22411836;24374639;25681444;32597660;33481703;33491328;7813015;7961739;8183345;8269516;8631896;9169871", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY07;E9P8Y6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005675 transcription factor TFIIH holo complex;GO:0000112 nucleotide-excision repair factor 3 complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q04673-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04705-1", "uniprot_id": "PRM6_YEAST", "mass": 41372.0, "length": 352, "protein_name": "Pheromone-regulated membrane protein 6", "gene_name": "PRM6", "organism": "Yeast", "refseq_name": "pheromone-regulated K(+) transporter PRM6", "refseq_ac": "NP_013666", "gene_names_uniprotkb": "PRM6; KCH2; YM9827.05C", "gene_names_refseq": "KCH2; PRM6", "protein_names_uniprotkb": "Pheromone-regulated membrane protein 6; Low affinity K(+) transporter 2", "protein_names_refseq": "pheromone-regulated K(+) transporter PRM6", "tax_id": 559292, "disease": "", "pathway": " (sce:YML047C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11062271;17322287;19684113;21252230;23204190;24374639;33491328;9169872", "class_list": "", "function": "Low affinity potassium transporter that, with KCH1, participates in high-affinity Ca(2+) influx system (HACS) activation during the response to mating pheromone (PubMed:21252230, PubMed:23204190). Directly promotes K(+) influx and HACS may electrochemically respond to this K(+) influx (PubMed:23204190). KCH1 and PRM6/KCH2 act at the apex of the calcium signaling pathway that is used for survival during prolonged exposures to mating pheromones (PubMed:23204190)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZC8", "ec_number_list": "", "go_molecular_function": "GO:0015079 potassium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005775 vacuolar lumen;GO:0000324 fungal-type vacuole;GO:0005934 cellular bud tip;GO:0043332 mating projection tip", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04705-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04711-1", "uniprot_id": "YM11B_YEAST", "mass": 198525.0, "length": 1755, "protein_name": "Transposon Ty1-ML1 Gag-Pol polyprotein", "gene_name": "TY1B-ML1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_013668", "gene_names_uniprotkb": "TY1B-ML1; YM9827.08; YMLWTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-ML1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YML045W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169872;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VZD0", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q04711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04728-1", "uniprot_id": "ARGJ_YEAST", "mass": 47849.0, "length": 441, "protein_name": "Arginine biosynthesis bifunctional protein ArgJ, mitochondrial", "gene_name": "ARG7", "organism": "Yeast", "refseq_name": "glutamate N-acetyltransferase", "refseq_ac": "NP_013778", "gene_names_uniprotkb": "ARG7; ECM40; YM9916.01C", "gene_names_refseq": "ARG7; ECM40", "protein_names_uniprotkb": "Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; AGS; Extracellular mutant protein 40; N-acetylglutamate synthase; OATase; Ornithine acetyltransferase; Ornithine transacetylase", "protein_names_refseq": "glutamate N-acetyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR062C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10753950;14576278;17651682;24374639;33481703;7705341;9169872;9428669", "class_list": "", "function": "Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZN6;Q04682;Q09168", "ec_number_list": "2.3.1.1;2.3.1.35", "go_molecular_function": "GO:0004042 L-glutamate N-acetyltransferase activity;GO:0004358 L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006526 L-arginine biosynthetic process;GO:0006592 ornithine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04728-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04746-1", "uniprot_id": "KAR5_YEAST", "mass": 58440.0, "length": 504, "protein_name": "Nuclear fusion protein KAR5", "gene_name": "KAR5", "organism": "Yeast", "refseq_name": "Kar5p", "refseq_ac": "NP_013781", "gene_names_uniprotkb": "KAR5; FIG3; YM9916.04", "gene_names_refseq": "FIG3; KAR5", "protein_names_uniprotkb": "Nuclear fusion protein KAR5; Factor-induced gene 3 protein; Karyogamy protein 5", "protein_names_refseq": "Kar5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR065W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10069807;11125145;19297527;24374639;8051211;9169872;9382856;9456310", "class_list": "", "function": "Required for nuclear membrane fusion during karyogamy., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VZN9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000742 karyogamy involved in conjugation with cellular fusion;GO:0048288 nuclear membrane fusion involved in karyogamy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q04746-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04779-1", "uniprot_id": "RCO1_YEAST", "mass": 78836.0, "length": 684, "protein_name": "Transcriptional regulatory protein RCO1", "gene_name": "RCO1", "organism": "Yeast", "refseq_name": "Rco1p", "refseq_ac": "NP_013791", "gene_names_uniprotkb": "RCO1; YM9916.14", "gene_names_refseq": "RCO1", "protein_names_uniprotkb": "Transcriptional regulatory protein RCO1", "protein_names_refseq": "Rco1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR075W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562095;14562106;15665377;16286008;18407956;19684113;19779198;19795423;19823750;20190278;21126336;21177495;22218487;22814378;23749301;24374639;30516470;32597660;33229814;33481703;33491328;9169872", "class_list": "", "function": "Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VZP9", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000118 histone deacetylase complex;GO:0032221 Rpd3S complex", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q04779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04921-1", "uniprot_id": "SPR28_YEAST", "mass": 48193.0, "length": 423, "protein_name": "Sporulation-regulated protein 28", "gene_name": "SPR28", "organism": "Yeast", "refseq_name": "septin SPR28", "refseq_ac": "NP_010504", "gene_names_uniprotkb": "SPR28; YD9934.03C", "gene_names_refseq": "SPR28", "protein_names_uniprotkb": "Sporulation-regulated protein 28", "protein_names_refseq": "septin SPR28", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR218C)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24374639;8885406;9169867", "class_list": "", "function": "Septins are GTPases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSK1", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005940 septin ring;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle", "go_biological_process": "GO:0000915 actomyosin contractile ring assembly;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0000917 division septum assembly;GO:0030437 ascospore formation;GO:0032186 cellular bud neck septin ring organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q04921-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04947-1", "uniprot_id": "RTN1_YEAST", "mass": 32916.0, "length": 295, "protein_name": "Reticulon-like protein 1", "gene_name": "RTN1", "organism": "Yeast", "refseq_name": "Rtn1p", "refseq_ac": "NP_010519", "gene_names_uniprotkb": "RTN1", "gene_names_refseq": "RTN1", "protein_names_uniprotkb": "Reticulon-like protein 1", "protein_names_refseq": "Rtn1p", "tax_id": 559292, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (sce:YDR233C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12832288;14562095;14562106;16847258;17322287;17563356;18407956;19779198;19795423;19823750;20498018;21126336;21177495;23749301;24374639;32597660;33229814;33481703;33491328;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VSL4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0009617 response to bacterium;GO:0034976 response to endoplasmic reticulum stress;GO:0032581 ER-dependent peroxisome organization;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q04947-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04951-1", "uniprot_id": "SCW10_YEAST", "mass": 40469.0, "length": 389, "protein_name": "Probable family 17 glucosidase SCW10", "gene_name": "SCW10", "organism": "Yeast", "refseq_name": "putative family 17 glucosidase", "refseq_ac": "NP_014035", "gene_names_uniprotkb": "SCW10; YM9952.07C", "gene_names_refseq": "SCW10", "protein_names_uniprotkb": "Probable family 17 glucosidase SCW10; 3.2.1.-; Soluble cell wall protein 10", "protein_names_refseq": "putative family 17 glucosidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR305C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14562106;24374639;9169872;9748433", "class_list": "", "function": "Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0D2", "ec_number_list": "", "go_molecular_function": "GO:0015926 glucosidase activity;GO:0042973 glucan endo-1,3-beta-D-glucosidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0071944 cell periphery", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0000747 conjugation with cellular fusion;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q04951-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04958-1", "uniprot_id": "NTE1_YEAST", "mass": 187133.0, "length": 1679, "protein_name": "Lysophospholipase NTE1", "gene_name": "NTE1", "organism": "Yeast", "refseq_name": "lysophospholipase", "refseq_ac": "NP_013652", "gene_names_uniprotkb": "NTE1; YM9958.03C", "gene_names_refseq": "NTE1", "protein_names_uniprotkb": "Lysophospholipase NTE1; 3.1.1.5; Intracellular phospholipase B; Neuropathy target esterase homolog", "protein_names_refseq": "lysophospholipase", "tax_id": 559292, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); hereditary spastic paraplegia 39 (Disease Ontology:DOID:0110790); Boucher-Neuhauser syndrome (Disease Ontology:DOID:0111265); Oliver-McFarlane syndrome (Disease Ontology:DOID:0111271); neurodegenerative disease (Disease Ontology:DOID:1289); blindness (Disease Ontology:DOID:1432); Laurence-Moon syndrome (Disease Ontology:DOID:1930); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (sce:YML059C); (R-SCE-6814848)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "14562095;14562106;15044461;15611060;15665377;16777854;16847258;17330950;17563356;18407956;19684113;19779198;19795423;19823750;19841481;20702584;23749301;24374639;24868093;27821475;32597660;33229814;33481703;33491328;34965436;9169872", "class_list": "", "function": "Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (PubMed:15044461, PubMed:15611060, PubMed:16777854). NTE1 activity impacts the repressing transcriptional activity of OPI1, the main regulator of phospholipid synthesis gene transcription (PubMed:19841481)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VZB4", "ec_number_list": "3.1.1.5", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0102545 phospholipase B activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0071071 regulation of phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q04958-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05031-1", "uniprot_id": "DFG5_YEAST", "mass": 50541.0, "length": 458, "protein_name": "Mannan endo-1,6-alpha-mannosidase DFG5", "gene_name": "DFG5", "organism": "Yeast", "refseq_name": "putative mannan endo-1,6-alpha-mannosidase", "refseq_ac": "NP_013965", "gene_names_uniprotkb": "DFG5; YM9959.20", "gene_names_refseq": "DFG5", "protein_names_uniprotkb": "Mannan endo-1,6-alpha-mannosidase DFG5; 3.2.1.101; Endo-alpha-1->6-D-mannanase DFG5", "protein_names_refseq": "putative mannan endo-1,6-alpha-mannosidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR238W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12421307;14562106;19756047;24374639;9169872", "class_list": "", "function": "Required for normal synthesis of the cell wall., [UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D6W064", "ec_number_list": "", "go_molecular_function": "GO:0008496 mannan endo-1,6-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0016052 carbohydrate catabolic process;GO:0007117 budding cell bud growth;GO:0007124 pseudohyphal growth;GO:0009272 fungal-type cell wall biogenesis;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q05031-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05123-1", "uniprot_id": "ARP9_YEAST", "mass": 53074.0, "length": 467, "protein_name": "Actin-like protein ARP9", "gene_name": "ARP9", "organism": "Yeast", "refseq_name": "Arp9p", "refseq_ac": "NP_013747", "gene_names_uniprotkb": "ARP9; SWP59; YM9973.07", "gene_names_refseq": "ARP9; RSC12; SWP59", "protein_names_uniprotkb": "Actin-like protein ARP9; Chromatin structure-remodeling complex protein ARP9; SWI/SNF complex component ARP9", "protein_names_refseq": "Arp9p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR033W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10025404;10329629;10619019;12072455;12183366;12697820;12805231;14562106;16204215;24374639;33491328;8980231;9169872;9290209;9844636", "class_list": "", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in transcriptional regulation. Heterodimer of ARP9 and ARP7 functions with HMG box proteins to facilitate proper chromatin architecture. Heterodimer formation is necessary for assembly into RSC complex. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZK8", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q05123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05164-1", "uniprot_id": "HPF1_YEAST", "mass": 94706.0, "length": 967, "protein_name": "Haze protective factor 1", "gene_name": "HPF1", "organism": "Yeast", "refseq_name": "mannoprotein", "refseq_ac": "NP_014487", "gene_names_uniprotkb": "HPF1; AOF1001", "gene_names_refseq": "HPF1", "protein_names_uniprotkb": "Haze protective factor 1", "protein_names_refseq": "mannoprotein", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL155C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10775354;11748726;11935221;16086015;17024473;23749301;24374639;8810044;9169874", "class_list": "", "function": "Involved in cell wall organization and biosynthesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W1R6;Q08294", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q05164-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05359-1", "uniprot_id": "ERP1_YEAST", "mass": 24723.0, "length": 219, "protein_name": "Protein ERP1", "gene_name": "ERP1", "organism": "Yeast", "refseq_name": "Erp1p", "refseq_ac": "NP_009402", "gene_names_uniprotkb": "ERP1; YAR002A", "gene_names_refseq": "ERP1", "protein_names_uniprotkb": "Protein ERP1", "protein_names_refseq": "Erp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YAR002C-A); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10359606;10713261;14562106;16847258;17322287;23749301;24374639;7731988;7941740", "class_list": "", "function": "Involved in vesicular protein trafficking., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPL7;E9P8S8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006900 vesicle budding from membrane;GO:0007030 Golgi organization;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q05359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05515-1", "uniprot_id": "SVF1_YEAST", "mass": 54368.0, "length": 481, "protein_name": "Ceramide-binding protein SVF1", "gene_name": "SVF1", "organism": "Yeast", "refseq_name": "Svf1p", "refseq_ac": "NP_010633", "gene_names_uniprotkb": "SVF1; SGI1", "gene_names_refseq": "SGI1; SVF1", "protein_names_uniprotkb": "Ceramide-binding protein SVF1", "protein_names_refseq": "Svf1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR346C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12244097;14562095;14562106;16034825;24374639;33481703;33491328;36897280;9169867", "class_list": "", "function": "Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids (PubMed:36897280). Required for survival in response to oxidative stress (PubMed:16034825). Involved in the diauxic shift (PubMed:12244097)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSX6", "ec_number_list": "", "go_molecular_function": "GO:0097001 ceramide binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0034599 cellular response to oxidative stress;GO:0035621 ER to Golgi ceramide transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q05515-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05521-1", "uniprot_id": "DPP1_YEAST", "mass": 33514.0, "length": 289, "protein_name": "Diacylglycerol pyrophosphate phosphatase 1", "gene_name": "DPP1", "organism": "Yeast", "refseq_name": "bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase", "refseq_ac": "NP_010570", "gene_names_uniprotkb": "DPP1; ZRG1", "gene_names_refseq": "DPP1; ZRG1", "protein_names_uniprotkb": "Diacylglycerol pyrophosphate phosphatase 1; 3.1.3.106; 3.1.3.4; 3.6.1.75; DGPP phosphatase; Lysophosphatidate phosphatase; Phosphatidate phosphatase", "protein_names_refseq": "bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase", "tax_id": 559292, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (sce:YDR284C); (R-SCE-2029485); (R-SCE-419408); (R-SCE-9845614)", "pathway_count": 4, "publication_count": 24, "publication_id_list": "10329682;10545184;11139591;12799368;14562095;14562106;14630917;14642771;15665377;17322287;17330950;18407956;19684113;19779198;21126336;23749301;24374639;32597660;33481703;33491328;8567632;8940025;9169867;9452443", "class_list": "", "function": "Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with LPP1, regulates intracellular DGPP and PA levels, which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. Substrate preference is DGPP > LPA > PA. Activity is independent of a divalent cation ion and insensitive to inhibition by N-ethylmaleimide., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSR4", "ec_number_list": "3.1.3.4;3.1.3.106;3.6.1.75", "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0042802 identical protein binding;GO:0008195 phosphatidate phosphatase activity;GO:0000810 diacylglycerol diphosphate phosphatase activity", "go_cellular_component": "GO:0016020 membrane;GO:0045121 membrane raft;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q05521-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05533-1", "uniprot_id": "INM2_YEAST", "mass": 32093.0, "length": 292, "protein_name": "Inositol monophosphatase 2", "gene_name": "INM2", "organism": "Yeast", "refseq_name": "inositol monophosphate 1-phosphatase INM2", "refseq_ac": "NP_010573", "gene_names_uniprotkb": "INM2; IMP2", "gene_names_refseq": "INM2", "protein_names_uniprotkb": "Inositol monophosphatase 2; 3.1.3.25; IMP 2; IMPase 2; Inositol-1(or 4)-monophosphatase 2", "protein_names_refseq": "inositol monophosphate 1-phosphatase INM2", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder 59 (Disease Ontology:DOID:0081221); intellectual disability (Disease Ontology:DOID:1059); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YDR287W); (R-SCE-1855183)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10096091;12593845;17322287;24374639;33491328;9169867", "class_list": "", "function": "Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSR7", "ec_number_list": "3.1.3.25", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008934 inositol monophosphate 1-phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007165 signal transduction;GO:0006021 inositol biosynthetic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0071545 inositol phosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05541-1", "uniprot_id": "NSE3_YEAST", "mass": 33965.0, "length": 303, "protein_name": "Non-structural maintenance of chromosome element 3", "gene_name": "NSE3", "organism": "Yeast", "refseq_name": "Smc5-Smc6 complex subunit NSE3", "refseq_ac": "NP_010574", "gene_names_uniprotkb": "NSE3", "gene_names_refseq": "NSE3", "protein_names_uniprotkb": "Non-structural maintenance of chromosome element 3; Non-SMC element 3", "protein_names_refseq": "Smc5-Smc6 complex subunit NSE3", "tax_id": 559292, "disease": "Prader-Willi syndrome (Disease Ontology:DOID:11983)", "pathway": " (sce:YDR288W); (R-SCE-114608); (R-SCE-3108214)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "14562095;14562106;14690591;15738391;15752197;17322287;19795423;19823750;22218487;24374639;33491328;9169867", "class_list": "", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSR8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0140588 chromatin looping", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05541-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05549-1", "uniprot_id": "HRQ1_YEAST", "mass": 123550.0, "length": 1077, "protein_name": "ATP-dependent helicase HRQ1", "gene_name": "HRQ1", "organism": "Yeast", "refseq_name": "ATP-dependent 3'-5' DNA helicase", "refseq_ac": "NP_010577", "gene_names_uniprotkb": "HRQ1", "gene_names_refseq": "HRQ1", "protein_names_uniprotkb": "ATP-dependent helicase HRQ1; 5.6.2.4; DNA 3'-5' helicase HRQ1; Homologous to recQ protein 1", "protein_names_refseq": "ATP-dependent 3'-5' DNA helicase", "tax_id": 559292, "disease": "Baller-Gerold syndrome (Disease Ontology:DOID:0050654); rapadilino syndrome (Disease Ontology:DOID:0050774); breast cancer (Disease Ontology:DOID:1612); Rothmund-Thomson syndrome (Disease Ontology:DOID:2732)", "pathway": " (sce:YDR291W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10077188;14562095;14562106;18701350;21177495;23026052;23456718;24374639;24440721;24682993;24700328;33491328;33502312;9169867", "class_list": "", "function": "DNA 3'-5' helicase involved in genome stability (PubMed:23456718, PubMed:24440721, PubMed:24700328). Functions in the RAD4-dependent nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair (PubMed:24440721, PubMed:24682993). Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA (PubMed:23026052). Activity is significantly stimulated by a preexisting fork structure (PubMed:24682993). Shows both processive helicase and DNA strand annealing activities (PubMed:24682993). Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding (PubMed:24440721)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSS0", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0016887 ATP hydrolysis activity;GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0032202 telomere assembly;GO:0036297 interstrand cross-link repair;GO:0006289 nucleotide-excision repair;GO:0042275 error-free postreplication DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q05549-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05567-1", "uniprot_id": "SGPL_YEAST", "mass": 65566.0, "length": 589, "protein_name": "Sphingosine-1-phosphate lyase", "gene_name": "DPL1", "organism": "Yeast", "refseq_name": "sphinganine-1-phosphate aldolase DPL1", "refseq_ac": "NP_010580", "gene_names_uniprotkb": "DPL1; BST1; D9819.5", "gene_names_refseq": "BST1; DPL1", "protein_names_uniprotkb": "Sphingosine-1-phosphate lyase; 4.1.2.-; 4.1.2.27; Bestowed of sphingosine tolerance 1; S1PL; SP-lyase; Sphingosine-1-phosphate aldolase; ySPL", "protein_names_refseq": "sphinganine-1-phosphate aldolase DPL1", "tax_id": 559292, "disease": "RENI syndrome (Disease Ontology:DOID:0080265); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); nephrotic syndrome (Disease Ontology:DOID:1184); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YDR294C); (R-SCE-9845614)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10329480;11795842;14562106;18487605;19795423;19823750;20696404;24374639;25345524;33491328;9169867;9334171;9464245", "class_list": "", "function": "Sphingosine-1-phosphate lyase that cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:20696404, PubMed:25345524, PubMed:9334171). Prefers C-16 dihydrosphingosine-l-phosphate (DHS-P) as a substrate. Regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs) (PubMed:11795842). Plays a role in the regulation of global responses to nutrient deprivation in yeast (PubMed:10329480)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VSS3", "ec_number_list": "4.1.2.27;4.1.2.-", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0008117 sphinganine-1-phosphate aldolase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0019722 calcium-mediated signaling;GO:0006665 sphingolipid metabolic process;GO:0009267 cellular response to starvation;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q05567-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05580-1", "uniprot_id": "HEL2_YEAST", "mass": 72756.0, "length": 639, "protein_name": "E3 ubiquitin-protein ligase HEL2", "gene_name": "HEL2", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase HEL2", "refseq_ac": "NP_010552", "gene_names_uniprotkb": "HEL2", "gene_names_refseq": "HEL2; RQT1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HEL2; 2.3.2.27; Histone E3 ligase 2; RING-type E3 ubiquitin transferase HEL2", "protein_names_refseq": "E3 ubiquitin-protein ligase HEL2", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR266C)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "14562095;14562106;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21177495;22570702;22814378;23749301;24374639;28223409;28757607;28943311;30609991;30718516;30893611;31532761;31819057;32203490;32597660;32615089;33229814;33338396;33481703;33491328;33761353;36627279;9169867", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28223409, PubMed:28757607, PubMed:30609991, PubMed:31532761, PubMed:31819057, PubMed:32203490, PubMed:32615089, PubMed:33338396, PubMed:36627279). HEL2 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28757607). Acts as a ribosome collision sensor: specifically recognizes and binds collided ribosome and ubiquitinates the 40S ribosomal proteins RPS20/uS10 and RPS3/uS3 (PubMed:30609991, PubMed:31819057, PubMed:32203490, PubMed:32615089). Catalyzes 'Lys-63'-linked polyubiquitination of RPS20/uS10, promoting recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:30609991, PubMed:31819057, PubMed:36627279). HEL2 also acts as an activator of the No-Go decay (NGD) pathway by mediating polyubiquitination of monoubiquitinated RPS3/uS3 and RPS7/es7: RPS3/uS3 and RPS7/es7 are first monoubiquitinated by MAG2 and MOT2/NOT4, respectively, and HEL2 mediates formation of 'Lys-63'-linked polyubiquitin chains on monoubiquitin, leading to activation of the NGD pathway in a CUE2-mediated endonucleolytic cleavage (PubMed:28943311, PubMed:30609991, PubMed:30718516, PubMed:30893611). Polyubiquitination of RPS3/uS3 also triggers degradation of non-functional 18S rRNA (PubMed:30718516, PubMed:30893611). The RQC pathway and the integrated stress response (ISR) antagonize each other: HEL2 prevents the activation of GCN2, while GCN2 suppresses RQC activation (PubMed:32615089, PubMed:33338396). The RQC pathway functions as a preventive quality control in the secretory pathway: HEL2 binds preferentially to the pre-engaged secretory ribosome-nascent chain complexes and prevents mistargeting of secretory proteins into mitochondria (PubMed:33761353). Independently of its role in RQC, also involved in the polyubiquitination and proteasomal-degradation of excess histone proteins (PubMed:22570702)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6VSQ0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043022 ribosome binding;GO:0070181 small ribosomal subunit rRNA binding;GO:0170011 stalled ribosome sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070651 nonfunctional rRNA decay;GO:0010629 negative regulation of gene expression;GO:0016567 protein ubiquitination;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "Q05580-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05635-1", "uniprot_id": "RNH2B_YEAST", "mass": 39484.0, "length": 350, "protein_name": "Ribonuclease H2 subunit B", "gene_name": "RNH202", "organism": "Yeast", "refseq_name": "Rnh202p", "refseq_ac": "NP_010565", "gene_names_uniprotkb": "RNH202", "gene_names_refseq": "RNH202", "protein_names_uniprotkb": "Ribonuclease H2 subunit B; RNase H(202); RNase H2 subunit B; Ribonuclease HI subunit B; Rnh2B", "protein_names_refseq": "Rnh202p", "tax_id": 559292, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (sce:YDR279W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;14734815;16193328;17322287;21177495;22814378;23749301;24374639;33481703;33491328;9169867", "class_list": "", "function": "Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSQ9;Q6Q5R1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05635-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05775-1", "uniprot_id": "EIF3J_YEAST", "mass": 29564.0, "length": 265, "protein_name": "Eukaryotic translation initiation factor 3 subunit J", "gene_name": "HCR1", "organism": "Yeast", "refseq_name": "translation initiation factor eIF3 core subunit j", "refseq_ac": "NP_013293", "gene_names_uniprotkb": "HCR1; L8167.11", "gene_names_refseq": "HCR1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit J; Eukaryotic translation initiation factor 3 30 kDa subunit; High-copy suppressor of Rpg1 protein 1; eIF-3 30 kDa; eIF3j", "protein_names_refseq": "translation initiation factor eIF3 core subunit j", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR192C); (R-SCE-156827); (R-SCE-72649); (R-SCE-72695); (R-SCE-72702)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10488093;14562095;14562106;15665377;16581774;17322287;17330950;18407956;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;30516470;32027465;32597660;33289941;33481703;33491328;33856219;9169871", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYJ5", "ec_number_list": "", "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q05775-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05779-1", "uniprot_id": "COQ9_YEAST", "mass": 29958.0, "length": 260, "protein_name": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "gene_name": "COQ9", "organism": "Yeast", "refseq_name": "ubiquinone biosynthesis protein COQ9", "refseq_ac": "NP_013302", "gene_names_uniprotkb": "COQ9", "gene_names_refseq": "COQ9", "protein_names_uniprotkb": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "protein_names_refseq": "ubiquinone biosynthesis protein COQ9", "tax_id": 559292, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 5 (Disease Ontology:DOID:0070242)", "pathway": " (sce:YLR201C); (R-SCE-2142789)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562095;14562106;14576278;16027161;17287358;24374639;25339443;33491328;9169871", "class_list": "", "function": "Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step (By similarity). Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:16027161, PubMed:25339443)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYK3", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q05779-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05900-1", "uniprot_id": "RU1C_YEAST", "mass": 27045.0, "length": 231, "protein_name": "U1 small nuclear ribonucleoprotein C", "gene_name": "YHC1", "organism": "Yeast", "refseq_name": "Yhc1p", "refseq_ac": "NP_013401", "gene_names_uniprotkb": "YHC1; L8003.21", "gene_names_refseq": "YHC1", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C; U1C", "protein_names_refseq": "Yhc1p", "tax_id": 559292, "disease": "mixed connective tissue disease (Disease Ontology:DOID:3492); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (sce:YLR298C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10072386;11172727;12214237;14562095;14562106;15465910;17322287;19941820;24374639;33491328;9012791;9169871;9233817;9630245", "class_list": "", "function": "Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYU2", "ec_number_list": "", "go_molecular_function": "GO:0030627 pre-mRNA 5'-splice site binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0000243 commitment complex;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q05900-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05902-1", "uniprot_id": "ECM38_YEAST", "mass": 73180.0, "length": 660, "protein_name": "Glutathione hydrolase proenzyme", "gene_name": "ECM38", "organism": "Yeast", "refseq_name": "gamma-glutamyltransferase", "refseq_ac": "NP_013402", "gene_names_uniprotkb": "ECM38; CIS2", "gene_names_refseq": "CIS2; ECM38", "protein_names_uniprotkb": "Glutathione hydrolase proenzyme; 2.3.2.2; 3.4.19.13; CIK1 suppressor protein 2; Extracellular mutant protein 38; Gamma-GT; Gamma-glutamyltransferase; Gamma-glutamyltranspeptidase", "protein_names_refseq": "gamma-glutamyltransferase", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); gamma-glutamyl transpeptidase deficiency (Disease Ontology:DOID:0111257); gestational diabetes (Disease Ontology:DOID:11714); biliary atresia (Disease Ontology:DOID:13608); melanoma (Disease Ontology:DOID:1909); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (sce:YLR299W); (R-SCE-174403); (R-SCE-2142691); (R-SCE-5423646); (R-SCE-9753281)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "11672438;12529169;12868055;14562106;1674526;24374639;6102906;6143552;6143574;9169871;9202464;9335584", "class_list": "", "function": "Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides. Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH. Plays a role in the turnover of the vacuolar GSH, serving as an alternative nitrogen source during nitrogen starvation., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VYU3", "ec_number_list": "2.3.2.2;3.4.19.13", "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005774 vacuolar membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0006508 proteolysis;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05902-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05919-1", "uniprot_id": "VPS38_YEAST", "mass": 50860.0, "length": 439, "protein_name": "Vacuolar protein sorting-associated protein 38", "gene_name": "VPS38", "organism": "Yeast", "refseq_name": "Vps38p", "refseq_ac": "NP_013464", "gene_names_uniprotkb": "VPS38; L8039.11; VPL17", "gene_names_refseq": "VPL17; VPS38", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 38", "protein_names_refseq": "Vps38p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR360W); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11157979;12244127;14562095;14562106;17322287;24374639;26450213;32597660;32690699;33491328;9169871;9265642", "class_list": "", "function": "Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (PubMed:11157979, PubMed:12244127, PubMed:9265642). This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome) (PubMed:11157979, PubMed:12244127, PubMed:9265642). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane (PubMed:11157979)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYZ7;Q6B1J7", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0010008 endosome membrane;GO:0000323 lytic vacuole;GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0015031 protein transport;GO:0016236 macroautophagy;GO:0035493 SNARE complex assembly;GO:0045324 late endosome to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05919-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05934-1", "uniprot_id": "VID22_YEAST", "mass": 102500.0, "length": 901, "protein_name": "Vacuolar import and degradation protein 22", "gene_name": "VID22", "organism": "Yeast", "refseq_name": "Vid22p", "refseq_ac": "NP_013477", "gene_names_uniprotkb": "VID22", "gene_names_refseq": "VID22", "protein_names_uniprotkb": "Vacuolar import and degradation protein 22", "protein_names_refseq": "Vid22p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR373C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11641409;11861771;14562095;14562106;17563356;19779198;21126336;23749301;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Has a role in the negative regulation of gluconeogenesis. Imports fructose-1,6-bisphosphatase (FBPase) into the intermediate vacuole import and degradation (Vid) vesicles. This is an indirect role and requires cyclophilin A., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ10", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005773 vacuole", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0015031 protein transport;GO:0007039 protein catabolic process in the vacuole", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q05934-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05946-1", "uniprot_id": "UTP13_YEAST", "mass": 91032.0, "length": 817, "protein_name": "U3 small nucleolar RNA-associated protein 13", "gene_name": "UTP13", "organism": "Yeast", "refseq_name": "U3 snoRNA-associated protein UTP13", "refseq_ac": "NP_013323", "gene_names_uniprotkb": "UTP13", "gene_names_refseq": "UTP13", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 13; U three protein 13; U3 snoRNA-associated protein 13", "protein_names_refseq": "U3 snoRNA-associated protein UTP13", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR222C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12068309;14562106;18407956;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYM2", "ec_number_list": "", "go_molecular_function": "GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0034388 Pwp2p-containing subcomplex of 90S preribosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q05946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q05958-1", "uniprot_id": "ECM22_YEAST", "mass": 89286.0, "length": 814, "protein_name": "Sterol regulatory element-binding protein ECM22", "gene_name": "ECM22", "organism": "Yeast", "refseq_name": "Ecm22p", "refseq_ac": "NP_013329", "gene_names_uniprotkb": "ECM22", "gene_names_refseq": "ECM22", "protein_names_uniprotkb": "Sterol regulatory element-binding protein ECM22; Extracellular mutant protein 22", "protein_names_refseq": "Ecm22p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR228C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11208779;11292809;11533229;14562095;14562106;18407956;19779198;20702584;21126336;23749301;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Transcription factor involved in sterol uptake and regulation of sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters and regulates transcription of ERG2 and ERG3 in response to sterol levels. Seems to be involved in activation of DAN2 and DAN3 cell wall mannoproteins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYN0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0070452 positive regulation of ergosterol biosynthetic process;GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q05958-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06010-1", "uniprot_id": "STE23_YEAST", "mass": 117579.0, "length": 1027, "protein_name": "A-factor-processing enzyme", "gene_name": "STE23", "organism": "Yeast", "refseq_name": "metalloendopeptidase", "refseq_ac": "NP_013493", "gene_names_uniprotkb": "STE23; L8084.12", "gene_names_refseq": "STE23", "protein_names_uniprotkb": "A-factor-processing enzyme; 3.4.24.-; Insulin-degrading enzyme homolog", "protein_names_refseq": "metalloendopeptidase", "tax_id": 559292, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YLR389C); (R-SCE-9033241)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12844361;15944156;18407956;19750477;23749301;24374639;26928762;28228553;32597660;33481703;33491328;7569998;9169871", "class_list": "", "function": "Involved in the N-terminal endoproteolytic cleavage of the P2 precursor of the a-factor mating pheromone. Capable of proteolysing the established mammalian insulin-degrading enzymes (IDEs) substrates amyloid-beta peptide and insulin B-chain., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ24;E9P8R3", "ec_number_list": "1.11.1.6;1.6.2.4;1.1.1.42;1.3.1.124;2.3.1.7;4.1.2.63;3.1.2.2;2.3.2.27;5.3.3.8;3.4.24.-;3.6.1.-;3.6.1.56;3.6.1.77", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043171 peptide catabolic process;GO:0034982 mitochondrial protein processing;GO:0051603 proteolysis involved in protein catabolic process;GO:0019236 response to pheromone;GO:0007323 peptide pheromone maturation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q06010-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06053-1", "uniprot_id": "DUS3_YEAST", "mass": 76596.0, "length": 668, "protein_name": "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]", "gene_name": "DUS3", "organism": "Yeast", "refseq_name": "tRNA dihydrouridine synthase DUS3", "refseq_ac": "NP_013505", "gene_names_uniprotkb": "DUS3; L8084.19", "gene_names_refseq": "DUS3", "protein_names_uniprotkb": "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; 1.3.1.-; 1.3.1.89; mRNA-dihydrouridine synthase DUS3; tRNA-dihydrouridine synthase 3", "protein_names_refseq": "tRNA dihydrouridine synthase DUS3", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR401C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12003496;12748633;12844361;14562095;14970222;18407956;19779198;19795423;19823750;22814378;23749301;24374639;32597660;33481703;33491328;7816623;9169871", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:12003496, PubMed:14970222). Specifically modifies U47 in cytoplasmic tRNAs (PubMed:14970222). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ35;P39519", "ec_number_list": "1.3.1.-;1.3.1.91;1.3.1.88;1.3.1.89;1.3.1.90", "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0106414 mRNA dihydrouridine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034399 nuclear periphery", "go_biological_process": "GO:0006397 mRNA processing;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q06053-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06058-1", "uniprot_id": "SEI1_YEAST", "mass": 32590.0, "length": 285, "protein_name": "Seipin", "gene_name": "SEI1", "organism": "Yeast", "refseq_name": "seipin", "refseq_ac": "NP_013508", "gene_names_uniprotkb": "SEI1; FLD1", "gene_names_refseq": "FLD1; SEI1", "protein_names_uniprotkb": "Seipin; Few lipid droplets protein 1", "protein_names_refseq": "seipin", "tax_id": 559292, "disease": "congenital generalized lipodystrophy (Disease Ontology:DOID:0050585); congenital generalized lipodystrophy type 2 (Disease Ontology:DOID:0111136)", "pathway": " (sce:YLR404W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12161108;12524434;14562106;16847258;18093937;18250201;21829381;24374639;25540432;9169871", "class_list": "", "function": "Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size (PubMed:18093937, PubMed:18250201). Facilitates initiation of LD formation, and ensures that vectorial budding of LDs from the ER is directed towards the cytoplasm (PubMed:25540432)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ37", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0046889 positive regulation of lipid biosynthetic process;GO:0055091 phospholipid homeostasis;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q06058-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06063-1", "uniprot_id": "DUS4_YEAST", "mass": 41696.0, "length": 367, "protein_name": "tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]", "gene_name": "DUS4", "organism": "Yeast", "refseq_name": "tRNA dihydrouridine synthase", "refseq_ac": "NP_013509", "gene_names_uniprotkb": "DUS4; L8084.2", "gene_names_refseq": "DUS4", "protein_names_uniprotkb": "tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]; 1.3.1.-; 1.3.1.90; mRNA-dihydrouridine synthase DUS4; tRNA-dihydrouridine synthase 4", "protein_names_refseq": "tRNA dihydrouridine synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR405W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562106;14970222;17322287;19779198;19795423;19823750;20702584;21126336;23749301;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:14970222). Specifically modifies U20a and U20b in cytoplasmic tRNAs (PubMed:14970222). Also able to mediate dihydrouridylation of some mRNAs, thereby affecting their translation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ38", "ec_number_list": "1.3.1.-;1.3.1.91;1.3.1.88;1.3.1.89;1.3.1.90", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0106414 mRNA dihydrouridine synthase activity;GO:0102266 tRNA-dihydrouridine20a synthase activity;GO:0102267 tRNA-dihydrouridine20b synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q06063-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06143-1", "uniprot_id": "DIC1_YEAST", "mass": 32992.0, "length": 298, "protein_name": "Mitochondrial dicarboxylate transporter", "gene_name": "DIC1", "organism": "Yeast", "refseq_name": "Dic1p", "refseq_ac": "NP_013452", "gene_names_uniprotkb": "DIC1", "gene_names_refseq": "DIC1", "protein_names_uniprotkb": "Mitochondrial dicarboxylate transporter; DTP; Dicarboxylate carrier 1", "protein_names_refseq": "Dic1p", "tax_id": 559292, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 19 (Disease Ontology:DOID:0070450)", "pathway": " (sce:YLR348C); (R-SCE-1614517); (R-SCE-428643)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10027973;11502005;14562095;14562106;14576278;15591051;24374639;25637873;8831951;9020177;9169871;9559855", "class_list": "", "function": "Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate (PubMed:25637873, PubMed:8831951, PubMed:9020177, PubMed:9559855). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Does not transport glutathione (PubMed:25637873). Required for growth on ethanol and acetate (PubMed:10027973)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYY7;P87332", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0005310 dicarboxylic acid transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0015117 thiosulfate transmembrane transporter activity;GO:0015131 oxaloacetate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1902358 sulfate transmembrane transport;GO:0006835 dicarboxylic acid transport;GO:0015709 thiosulfate transport;GO:0015729 oxaloacetate transport;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q06143-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06147-1", "uniprot_id": "LCB5_YEAST", "mass": 77566.0, "length": 687, "protein_name": "Sphingoid long chain base kinase 5", "gene_name": "LCB5", "organism": "Yeast", "refseq_name": "sphinganine kinase LCB5", "refseq_ac": "NP_013361", "gene_names_uniprotkb": "LCB5", "gene_names_refseq": "LCB5", "protein_names_uniprotkb": "Sphingoid long chain base kinase 5; 2.7.1.91; LCB kinase 5; Sphinganine kinase 5", "protein_names_refseq": "sphinganine kinase LCB5", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); adenocarcinoma (Disease Ontology:DOID:299); high grade glioma (Disease Ontology:DOID:3070); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YLR260W); (R-SCE-1483206); (R-SCE-1660661); (R-SCE-390471); (R-SCE-5218921); (R-SCE-9009391); (R-SCE-9833482)", "pathway_count": 7, "publication_count": 20, "publication_id_list": "11056159;11102354;11278643;12493772;14562106;17330950;17563356;18407956;19779198;20702584;21126336;23749301;24374639;25345524;30516470;32597660;33481703;33491328;9169871;9677363", "class_list": "", "function": "Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively (PubMed:11102354, PubMed:12493772, PubMed:25345524, PubMed:9677363). Redundant to LCB4, is only responsible for few percent of the total activity (PubMed:9677363). Involved in the biosynthesis of sphingolipids and ceramides (PubMed:25345524, PubMed:9677363). Involved in heat-induced transient cell cycle arrest (PubMed:11056159). Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling (PubMed:11102354, PubMed:11278643). Involved in heat-stress resistance (PubMed:11056159)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 34, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYQ7", "ec_number_list": "2.7.11.13;2.7.1.91", "go_molecular_function": "GO:0005524 ATP binding;GO:0008481 sphingosine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0006665 sphingolipid metabolic process;GO:0046512 sphingosine biosynthetic process;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q06147-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06156-1", "uniprot_id": "CND1_YEAST", "mass": 132967.0, "length": 1176, "protein_name": "Condensin complex subunit 1", "gene_name": "YCS4", "organism": "Yeast", "refseq_name": "condensin subunit YCS4", "refseq_ac": "NP_013374", "gene_names_uniprotkb": "YCS4; L8479.14; LOC7", "gene_names_refseq": "LOC7; YCS4", "protein_names_uniprotkb": "Condensin complex subunit 1; XCAP-D2 homolog", "protein_names_refseq": "condensin subunit YCS4", "tax_id": 559292, "disease": "primary autosomal recessive microcephaly 21 (Disease Ontology:DOID:0051032)", "pathway": " (sce:YLR272C); (R-SCE-2514853)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10811823;11854418;14562106;18407956;19481522;19779198;23749301;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYR9", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000796 condensin complex;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0051307 meiotic chromosome separation;GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0007130 synaptonemal complex assembly;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q06156-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06160-1", "uniprot_id": "SPH1_YEAST", "mass": 74007.0, "length": 661, "protein_name": "Protein SPH1", "gene_name": "SPH1", "organism": "Yeast", "refseq_name": "Sph1p", "refseq_ac": "NP_013417", "gene_names_uniprotkb": "SPH1", "gene_names_refseq": "SPH1; YLR312C-B", "protein_names_uniprotkb": "Protein SPH1; SPA2 homolog 1", "protein_names_refseq": "Sph1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR313C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11923536;14562095;14562106;15282802;16012843;23749301;24374639;33481703;33491328;9169871;9214378;9443897", "class_list": "", "function": "Polarity-determining protein which forms a conjugate with the ubiquitin-like modifier HUB1. Involved in bud site selection and cellular morphogenesis during conjugation. Required for pseudohyphal growth., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYV7;O13526;Q2VQW2", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0005826 actomyosin contractile ring;GO:1902716 cell cortex of growing cell tip;GO:0000131 incipient cellular bud site;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0008360 regulation of cell shape;GO:0007121 bipolar cellular bud site selection;GO:0007124 pseudohyphal growth;GO:0036267 invasive filamentous growth", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q06160-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06168-1", "uniprot_id": "SFH1_YEAST", "mass": 48777.0, "length": 426, "protein_name": "Chromatin structure-remodeling complex subunit SFH1", "gene_name": "SFH1", "organism": "Yeast", "refseq_name": "Sfh1p", "refseq_ac": "NP_013425", "gene_names_uniprotkb": "SFH1; L8543.4", "gene_names_refseq": "SFH1", "protein_names_uniprotkb": "Chromatin structure-remodeling complex subunit SFH1; RSC complex subunit SFH1; SNF5 homolog 1", "protein_names_refseq": "Sfh1p", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); Coffin-Siris syndrome 3 (Disease Ontology:DOID:0070045); schwannomatosis 1 (Disease Ontology:DOID:0070480); rhabdoid tumor predisposition syndrome 1 (Disease Ontology:DOID:0070618); sinonasal undifferentiated carcinoma (Disease Ontology:DOID:0080799); vestibular schwannomatosis (Disease Ontology:DOID:0111252); atypical teratoid rhabdoid tumor (Disease Ontology:DOID:2129); schwannomatosis (Disease Ontology:DOID:3204); meningioma (Disease Ontology:DOID:3565); rhabdoid cancer (Disease Ontology:DOID:3672); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); synovial sarcoma (Disease Ontology:DOID:5485); epithelioid sarcoma (Disease Ontology:DOID:6193); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YLR321C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10025404;10329629;10619019;12072455;12183366;12697820;14562106;18407956;21126336;23749301;24374639;32597660;33491328;8980231;9154831;9169871", "class_list": "", "function": "Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYW4", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000228 nuclear chromosome;GO:0016586 RSC-type complex", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007059 chromosome segregation;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q06168-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06201-1", "uniprot_id": "GMC2_YEAST", "mass": 22365.0, "length": 188, "protein_name": "Grand meiotic recombination cluster protein 2", "gene_name": "GMC2", "organism": "Yeast", "refseq_name": "Gmc2p", "refseq_ac": "NP_013550", "gene_names_uniprotkb": "GMC2", "gene_names_refseq": "GMC2", "protein_names_uniprotkb": "Grand meiotic recombination cluster protein 2", "protein_names_refseq": "Gmc2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR445W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10657304;12370439;12844361;16464826;17322287;22194413;24374639;33491328;33502312;9169871", "class_list": "", "function": "Probable transcriptional activator involved in meiotic prophase and synaptonemal complex (SC) assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ79", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005777 peroxisome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016925 protein sumoylation;GO:0007130 synaptonemal complex assembly;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q06201-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06204-1", "uniprot_id": "NGK1_YEAST", "mass": 48969.0, "length": 433, "protein_name": "N-acetylglucosamine kinase", "gene_name": "NGK1", "organism": "Yeast", "refseq_name": "hexokinase", "refseq_ac": "NP_013551", "gene_names_uniprotkb": "NGK1", "gene_names_refseq": "NGK1", "protein_names_uniprotkb": "N-acetylglucosamine kinase; 2.7.1.59", "protein_names_refseq": "hexokinase", "tax_id": 559292, "disease": "congenital nonspherocytic hemolytic anemia 5 (Disease Ontology:DOID:0051006); retinitis pigmentosa 79 (Disease Ontology:DOID:0061108); Charcot-Marie-Tooth disease type 4G (Disease Ontology:DOID:0110196); retinitis pigmentosa (Disease Ontology:DOID:10584); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); anemia (Disease Ontology:DOID:2355); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YLR446W); (R-SCE-170822); (R-SCE-446205); (R-SCE-6798695); (R-SCE-70171)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10847680;17322287;24374639;36216916;9169871;9784122", "class_list": "", "function": "N-acetylglucosamine (GlcNAc) kinase that transfers a phosphate onto GlcNAc to generate GlcNAc-6-phosphate, which can be a precursor for glycan synthesis (PubMed:36216916). Can utilize a broad range of NTPs, namely ATP, CTP, GTP, ITP, and UTP, as phosphoryl donors (PubMed:36216916). Shows only low glucose phosphorylation activity (PubMed:36216916). NGK1 may play a role under a certain condition as an alternative supply pathway GlcNAc-6-P as a precursor of UDP-GlcNAc (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ80;Q6B2U1", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0045127 N-acetylglucosamine kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0006013 mannose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06204-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06224-1", "uniprot_id": "YSH1_YEAST", "mass": 87674.0, "length": 779, "protein_name": "Endoribonuclease YSH1", "gene_name": "YSH1", "organism": "Yeast", "refseq_name": "cleavage polyadenylation factor subunit YSH1", "refseq_ac": "NP_013379", "gene_names_uniprotkb": "YSH1; BRR5", "gene_names_refseq": "BRR5; YSH1", "protein_names_uniprotkb": "Endoribonuclease YSH1; 3.1.27.-; Yeast 73 kDa homolog 1; mRNA 3'-end-processing protein YSH1", "protein_names_refseq": "cleavage polyadenylation factor subunit YSH1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR277C); (R-SCE-77595)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10619842;12626716;12819204;14562095;14562106;15037765;17563356;18407956;19795423;19823750;20190278;23749301;24374639;33481703;33491328;8929409;9169871", "class_list": "", "function": "Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Has endonuclease activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYS4", "ec_number_list": "3.1.27.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity;GO:0004534 5'-3' RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0034247 snoRNA splicing;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006369 termination of RNA polymerase II transcription;GO:0031126 sno(s)RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q06224-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06266-1", "uniprot_id": "TOS4_YEAST", "mass": 55468.0, "length": 489, "protein_name": "Protein TOS4", "gene_name": "TOS4", "organism": "Yeast", "refseq_name": "Tos4p", "refseq_ac": "NP_013284", "gene_names_uniprotkb": "TOS4; L94705.22", "gene_names_refseq": "TOS4", "protein_names_uniprotkb": "Protein TOS4; Target of SBF protein 4", "protein_names_refseq": "Tos4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR183C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11206552;12464632;14562106;14574415;15282802;15965243;17287358;17563356;18407956;19779198;23749301;24374639;33491328;9169871", "class_list": "", "function": "Binds to the promoters of genes with functions important for the G1/S (start) transition; primarily genes involved in pheromone response, polarized growth and transcription., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYI7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000785 chromatin;GO:0070210 Rpd3L-Expanded complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q06266-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06321-1", "uniprot_id": "ATG26_YEAST", "mass": 136054.0, "length": 1198, "protein_name": "Sterol 3-beta-glucosyltransferase", "gene_name": "ATG26", "organism": "Yeast", "refseq_name": "sterol 3-beta-glucosyltransferase", "refseq_ac": "NP_013290", "gene_names_uniprotkb": "ATG26; UGT51", "gene_names_refseq": "ATG26; UGT51", "protein_names_uniprotkb": "Sterol 3-beta-glucosyltransferase; 2.4.1.-; 2.4.1.173; Autophagy-related protein 26; UDP-glycosyltransferase 51", "protein_names_refseq": "sterol 3-beta-glucosyltransferase", "tax_id": 559292, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YLR189C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10224056;14536056;14562095;14562106;17012830;18407956;19779198;20702584;21126336;21177495;23749301;24374639;28479190;30395931;33481703;33491328;34965436;9169871", "class_list": "", "function": "Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside (PubMed:10224056, PubMed:30395931). Also shows activity in vitro on other sterols such as cholesterol, beta-sitosterol, stigmasterol and tomatidine (PubMed:10224056). In contrasts to what is observed in Pichia pastoris and Aspergillus oryzae, is not involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy in Saccharomyces cerevisiae (PubMed:17012830)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYJ2", "ec_number_list": "2.4.1.-;2.4.1.173", "go_molecular_function": "GO:0016906 sterol 3-beta-glucosyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0016126 sterol biosynthetic process;GO:0016125 sterol metabolic process;GO:0032120 ascospore-type prospore membrane formation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q06321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06324-1", "uniprot_id": "MMR1_YEAST", "mass": 54817.0, "length": 491, "protein_name": "Mitochondrial MYO2 receptor-related protein 1", "gene_name": "MMR1", "organism": "Yeast", "refseq_name": "Mmr1p", "refseq_ac": "NP_013291", "gene_names_uniprotkb": "MMR1", "gene_names_refseq": "MMR1", "protein_names_uniprotkb": "Mitochondrial MYO2 receptor-related protein 1", "protein_names_refseq": "Mmr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR190W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12006994;13679573;14562106;15201867;15665377;18407956;19684113;19779198;21177495;22218487;23749301;24374639;32597660;33481703;33491328;35422486;9169871", "class_list": "", "function": "Involved in the guiding of mitochondrial tubules to the bud tip during cell division., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYJ3", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0032541 cortical endoplasmic reticulum;GO:0000131 incipient cellular bud site;GO:0005933 cellular bud", "go_biological_process": "GO:0051301 cell division;GO:0048312 intracellular distribution of mitochondria;GO:0000001 mitochondrion inheritance", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q06324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06339-1", "uniprot_id": "TFC6_YEAST", "mass": 74709.0, "length": 672, "protein_name": "Transcription factor tau 91 kDa subunit", "gene_name": "TFC6", "organism": "Yeast", "refseq_name": "transcription factor TFIIIC subunit TFC6", "refseq_ac": "NP_010649", "gene_names_uniprotkb": "TFC6", "gene_names_refseq": "TFC6", "protein_names_uniprotkb": "Transcription factor tau 91 kDa subunit; TFIIIC 91 kDa subunit; Transcription factor C subunit 6", "protein_names_refseq": "transcription factor TFIIIC subunit TFC6", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR362C); (R-SCE-76061); (R-SCE-76066)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "12533520;14562095;14562106;16115780;17052456;18407956;19779198;23749301;24374639;2651441;32597660;33481703;33491328;7688737;9169867;9418847", "class_list": "", "function": "TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with TFC3 in DNA binding., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSZ0", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus", "go_biological_process": "GO:0042791 5S class rRNA transcription by RNA polymerase III;GO:0006383 transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q06339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06385-1", "uniprot_id": "VPS74_YEAST", "mass": 39287.0, "length": 345, "protein_name": "Vacuolar protein sorting-associated protein 74", "gene_name": "VPS74", "organism": "Yeast", "refseq_name": "Vps74p", "refseq_ac": "NP_010660", "gene_names_uniprotkb": "VPS74; D9481.15", "gene_names_refseq": "API1; MNN3; VPS74", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 74", "protein_names_refseq": "Vps74p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR372C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11875433;12134085;14562106;17287358;17563356;18407956;18410729;19779198;19837035;20026658;20702584;21126336;21177495;22889169;23749301;24019977;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT03", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0006487 protein N-linked glycosylation;GO:0043001 Golgi to plasma membrane protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q06385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06390-1", "uniprot_id": "MRB1_YEAST", "mass": 36052.0, "length": 306, "protein_name": "Methylated RNA-binding protein 1", "gene_name": "PHO92", "organism": "Yeast", "refseq_name": "mRNA-binding phosphate metabolism regulator", "refseq_ac": "NP_010662", "gene_names_uniprotkb": "PHO92; MRB1", "gene_names_refseq": "MRB1; PHO92", "protein_names_uniprotkb": "Methylated RNA-binding protein 1; PHOsphate metabolism protein 92; YTH domain-containing protein PHO92", "protein_names_refseq": "mRNA-binding phosphate metabolism regulator", "tax_id": 559292, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YDR374C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "24206186;24269006;24374639;26318451;9169867", "class_list": "", "function": "RNA-binding protein that acts as a post-transcriptional regulator of phosphate metabolism by binding to the 3'-UTR region of PHO4 mRNA, decreasing its stability (PubMed:24206186). Acts by recognizing and binding N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (PubMed:24269006, PubMed:26318451)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT05", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q06390-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06408-1", "uniprot_id": "ARO10_YEAST", "mass": 71384.0, "length": 635, "protein_name": "Transaminated amino acid decarboxylase", "gene_name": "ARO10", "organism": "Yeast", "refseq_name": "phenylpyruvate decarboxylase ARO10", "refseq_ac": "NP_010668", "gene_names_uniprotkb": "ARO10; D9481.3", "gene_names_refseq": "ARO10", "protein_names_uniprotkb": "Transaminated amino acid decarboxylase; 2ODC; 4.1.1.-; 4.1.1.43; 4.1.1.72; 4.1.1.74; 4.1.1.80; PPDC; Thiamine diphosphate-dependent phenylpyruvate decarboxylase; Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase; Transaminated branched-chain amino acid decarboxylase", "protein_names_refseq": "phenylpyruvate decarboxylase ARO10", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR380W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10207060;10753893;12499363;12872131;12902239;14562095;14562106;15933030;21501384;22814378;22904058;24374639;33491328;9169867", "class_list": "", "function": "One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) involved in amino acid catabolism. The enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids (alpha-keto-acids). In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids derived from phenylalanine (phenylpyruvate), tryptophan (3-(indol-3-yl)pyruvate), and probably tyrosine (4-hydroxyphenylpyruvate), but also isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate) and methionine (4-methylthio-2-oxobutanoate), whereas transaminated leucine (4-methyl-2-oxopentanoate, also alpha-keto-isocaproate) is a low efficiency substrate and transaminated valine and pyruvate are no substrates. In analogy to the pyruvate decarboxylases the enzyme may in a side-reaction catalyze condensation (or carboligation) reactions leading to the formation of 2-hydroxy ketone, collectively called acyloins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VT13", "ec_number_list": "4.1.1.-;4.1.1.43;4.1.1.72;4.1.1.74;4.1.1.80", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0016831 carboxy-lyase activity;GO:0004737 pyruvate decarboxylase activity;GO:0047433 branched-chain-2-oxoacid decarboxylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0006559 L-phenylalanine catabolic process;GO:0006552 L-leucine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q06408-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06409-1", "uniprot_id": "DCK1_YEAST", "mass": 221563.0, "length": 1932, "protein_name": "DOCK-like protein 1", "gene_name": "DCK1", "organism": "Yeast", "refseq_name": "guanine nucleotide exchange factor DCK1", "refseq_ac": "NP_013526", "gene_names_uniprotkb": "DCK1", "gene_names_refseq": "DCK1", "protein_names_uniprotkb": "DOCK-like protein 1", "protein_names_refseq": "guanine nucleotide exchange factor DCK1", "tax_id": 559292, "disease": "immunodeficiency 40 (Disease Ontology:DOID:0111951); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); DiGeorge syndrome (Disease Ontology:DOID:11198); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (sce:YLR422W); (R-SCE-6798695); (R-SCE-9013149); (R-SCE-983231)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "14562095;14562106;18407956;19779198;21177495;23749301;24374639;25598154;33229814;33481703;33491328;9169871", "class_list": "", "function": "Forms a transiant heterodimeric complex with LMO1, that acts as a guanine nucleotide exchange factor exchange factor (GEF) for the small GTPase RHO5 (PubMed:25598154). DCK1, LMO1 and RHO5 relocate to mitochondria upon oxidative stress and trigger cell death (PubMed:25598154). The DCK1/LMO1/RHO5 signaling module mediates mitochondrial turnover under nitrogen starvation conditions via mitophagy (PubMed:25598154). The DCK1/LMO1/RHO5 signaling module plays also a function in cell wall integrity signaling (PubMed:25598154)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 9, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 9, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 9, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ58", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q06409-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06440-1", "uniprot_id": "CORO_YEAST", "mass": 72553.0, "length": 651, "protein_name": "Coronin-like protein", "gene_name": "CRN1", "organism": "Yeast", "refseq_name": "coronin", "refseq_ac": "NP_013533", "gene_names_uniprotkb": "CRN1; L9576.2", "gene_names_refseq": "CRN1", "protein_names_uniprotkb": "Coronin-like protein", "protein_names_refseq": "coronin", "tax_id": 559292, "disease": "coronin-1A deficiency (Disease Ontology:DOID:0060019); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014); proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (sce:YLR429W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "11875433;14562106;15665377;17287358;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;24909858;30516470;32597660;33481703;33491328;9169871", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ64", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0030479 actin cortical patch", "go_biological_process": "GO:0071846 actin filament debranching;GO:0007015 actin filament organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0051666 actin cortical patch localization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q06440-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06488-1", "uniprot_id": "RSC2_YEAST", "mass": 102300.0, "length": 889, "protein_name": "Chromatin structure-remodeling complex subunit RSC2", "gene_name": "RSC2", "organism": "Yeast", "refseq_name": "Rsc2p", "refseq_ac": "NP_013461", "gene_names_uniprotkb": "RSC2; L9638.1", "gene_names_refseq": "RSC2", "protein_names_uniprotkb": "Chromatin structure-remodeling complex subunit RSC2; RSC complex subunit RSC2; Remodel the structure of chromatin complex subunit 2", "protein_names_refseq": "Rsc2p", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); lung small cell carcinoma (Disease Ontology:DOID:5409); Crohn's disease (Disease Ontology:DOID:8778); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YLR357W)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10025404;10329629;10619019;12024034;12072455;12183366;12697820;12702296;14562106;15665377;16079223;17330950;18407956;19684113;19779198;20190278;20702584;21126336;21177495;22218487;23749301;24374639;27821475;30516470;32597660;33481703;33491328;33502312;8980231;9169871", "class_list": "", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in meiotic sporulation through regulating IME2 expression, and is also essential for 2-micron plasmid maintenance and for normal REP1 protein localization., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYZ5", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007059 chromosome segregation;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006368 transcription elongation by RNA polymerase II;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q06488-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06489-1", "uniprot_id": "MTNA_YEAST", "mass": 45020.0, "length": 411, "protein_name": "Methylthioribose-1-phosphate isomerase", "gene_name": "MRI1", "organism": "Yeast", "refseq_name": "S-methyl-5-thioribose-1-phosphate isomerase MRI1", "refseq_ac": "NP_015443", "gene_names_uniprotkb": "MRI1; P9642.7", "gene_names_refseq": "MRI1", "protein_names_uniprotkb": "Methylthioribose-1-phosphate isomerase; 5.3.1.23; M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein", "protein_names_refseq": "S-methyl-5-thioribose-1-phosphate isomerase MRI1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR118W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;15215245;18407956;18625006;22814378;24374639;33481703;33491328;9169875", "class_list": "", "function": "Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)., [UniProtKB, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4B7", "ec_number_list": "5.3.1.23", "go_molecular_function": "GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q06489-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06493-1", "uniprot_id": "YLH47_YEAST", "mass": 52174.0, "length": 454, "protein_name": "LETM1 domain-containing protein YLH47, mitochondrial", "gene_name": "YLH47", "organism": "Yeast", "refseq_name": "Ylh47p", "refseq_ac": "NP_015450", "gene_names_uniprotkb": "YLH47; MRS7", "gene_names_refseq": "MRS7; YLH47", "protein_names_uniprotkb": "LETM1 domain-containing protein YLH47, mitochondrial; LETM1 homolog", "protein_names_refseq": "Ylh47p", "tax_id": 559292, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460)", "pathway": " (sce:YPR125W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;15138253;16476776;16823961;24374639;33491328;8252639;9169875", "class_list": "", "function": "Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4C3;P89103", "ec_number_list": "", "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:1902600 proton transmembrane transport;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q06493-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06504-1", "uniprot_id": "NAT3_YEAST", "mass": 22921.0, "length": 195, "protein_name": "N-terminal acetyltransferase B complex catalytic subunit NAT3", "gene_name": "NAT3", "organism": "Yeast", "refseq_name": "peptide alpha-N-acetyltransferase complex B subunit NAT3", "refseq_ac": "NP_015456", "gene_names_uniprotkb": "NAT3", "gene_names_refseq": "NAA20; NAT3; RAD56", "protein_names_uniprotkb": "N-terminal acetyltransferase B complex catalytic subunit NAT3; 2.3.1.254; NatB Nalpha terminal acetyltransferase 3; NatB complex subunit NAT3", "protein_names_refseq": "peptide alpha-N-acetyltransferase complex B subunit NAT3", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder 73 (Disease Ontology:DOID:0081233)", "pathway": " (sce:YPR131C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10545125;12783868;12808144;14562095;14562106;24374639;32597660;33491328;9169875", "class_list": "", "function": "Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn, Met-Gln or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions, it is presumed to N-acetylate 15% of all yeast proteins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W4C7", "ec_number_list": "2.3.1.254", "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031416 NatB complex", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0036503 ERAD pathway;GO:0017196 N-terminal peptidyl-methionine acetylation;GO:0000001 mitochondrion inheritance", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q06504-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06508-1", "uniprot_id": "LOA1_YEAST", "mass": 33816.0, "length": 300, "protein_name": "Lysophosphatidic acid:oleoyl-CoA acyltransferase 1", "gene_name": "LOA1", "organism": "Yeast", "refseq_name": "lysophosphatidic acid acyltransferase LOA1", "refseq_ac": "NP_015465", "gene_names_uniprotkb": "LOA1; VPS66", "gene_names_refseq": "LOA1; VPS66", "protein_names_uniprotkb": "Lysophosphatidic acid:oleoyl-CoA acyltransferase 1; 2.3.1.51; LPAAT; Lysophosphatidic acid acyltransferase; Vacuolar protein sorting-associated protein 66", "protein_names_refseq": "lysophosphatidic acid acyltransferase LOA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR139C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12134085;14562106;17322287;21820081;22090344;24374639;9169875", "class_list": "", "function": "Acyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4D7", "ec_number_list": "2.3.1.51;2.3.1.23;2.3.1.n7;2.3.1.n6", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0034389 lipid droplet organization;GO:0035356 intracellular triglyceride homeostasis;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q06508-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06511-1", "uniprot_id": "RRP15_YEAST", "mass": 28212.0, "length": 250, "protein_name": "Ribosomal RNA-processing protein 15", "gene_name": "RRP15", "organism": "Yeast", "refseq_name": "rRNA-processing protein RRP15", "refseq_ac": "NP_015469", "gene_names_uniprotkb": "RRP15", "gene_names_refseq": "RRP15", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 15", "protein_names_refseq": "rRNA-processing protein RRP15", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR143W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;15769876;17330950;19779198;19795423;19823750;20489023;20702584;21177495;22218487;24374639;33481703;33491328;9169875", "class_list": "", "function": "Constituent of pre-60S ribosomal particles. Required for large subunit rRNA maturation, in particular processing of the 27S pre-rRNA at the A3 and B1 sites to yield 5.8S and 25S rRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4E0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q06511-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06522-1", "uniprot_id": "YP147_YEAST", "mass": 34842.0, "length": 304, "protein_name": "Lipid droplet-associated triacylglycerol lipase", "gene_name": "", "organism": "Yeast", "refseq_name": "bifunctional triacylglycerol lipase/ester hydrolase", "refseq_ac": "NP_015473", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Lipid droplet-associated triacylglycerol lipase; 3.1.1.3; TAG lipase", "protein_names_refseq": "bifunctional triacylglycerol lipase/ester hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR147C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;24374639;24868093;29491250;9169875", "class_list": "", "function": "Shows both triacylglycerol (TAG) lipase and ester hydrolase activities. May play a role in TAG homeostasis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W4E4", "ec_number_list": "3.1.1.3;1.1.1.101", "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0019433 triglyceride catabolic process;GO:0019915 lipid storage;GO:0034389 lipid droplet organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q06522-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06541-1", "uniprot_id": "ARV1_YEAST", "mass": 38194.0, "length": 321, "protein_name": "Protein ARV1", "gene_name": "ARV1", "organism": "Yeast", "refseq_name": "sterol homeostasis protein ARV1", "refseq_ac": "NP_013343", "gene_names_uniprotkb": "ARV1", "gene_names_refseq": "ARV1", "protein_names_uniprotkb": "Protein ARV1", "protein_names_refseq": "sterol homeostasis protein ARV1", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 38 (Disease Ontology:DOID:0080417); lipid storage disease (Disease Ontology:DOID:9455)", "pathway": " (sce:YLR242C); (R-SCE-191273)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11063737;12145310;16012843;17322287;24374639;9169871", "class_list": "", "function": "Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Also regulates the sphingolipid metabolism. Required for growth during anaerobiosis and sterol uptake., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYP0;Q2VQX3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0006897 endocytosis;GO:0006665 sphingolipid metabolic process;GO:0030148 sphingolipid biosynthetic process;GO:0016125 sterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06541-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06549-1", "uniprot_id": "CDD_YEAST", "mass": 15536.0, "length": 142, "protein_name": "Cytidine deaminase", "gene_name": "CDD1", "organism": "Yeast", "refseq_name": "cytidine deaminase", "refseq_ac": "NP_013346", "gene_names_uniprotkb": "CDD1; L9672.13", "gene_names_refseq": "CDD1", "protein_names_uniprotkb": "Cytidine deaminase; 3.5.4.5; CDA; Cytidine aminohydrolase", "protein_names_refseq": "cytidine deaminase", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YLR245C); (R-SCE-6798695); (R-SCE-73614)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10501935;14562106;15148397;17322287;22814378;24374639;33491328;9169871", "class_list": "", "function": "This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYP3", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;3.5.1.3;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.2.1.14;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008655 pyrimidine-containing compound salvage;GO:0006216 cytidine catabolic process;GO:0006217 deoxycytidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06549-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06551-1", "uniprot_id": "ERFB_YEAST", "mass": 41099.0, "length": 359, "protein_name": "Palmitoyltransferase ERF2", "gene_name": "ERF2", "organism": "Yeast", "refseq_name": "palmitoyltransferase ERF2", "refseq_ac": "NP_013347", "gene_names_uniprotkb": "ERF2", "gene_names_refseq": "ERF2", "protein_names_uniprotkb": "Palmitoyltransferase ERF2; 2.3.1.225; DHHC cysteine-rich domain-containing protein ERF2; Ras protein acyltransferase", "protein_names_refseq": "palmitoyltransferase ERF2", "tax_id": 559292, "disease": "syndromic X-linked intellectual disability Raymond type (Disease Ontology:DOID:0060824)", "pathway": " (sce:YLR246W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10490616;12193598;12379641;16847258;17322287;24374639;33491328;9169871", "class_list": "", "function": "The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYP4;Q6B217", "ec_number_list": "2.3.1.225", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06551-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06554-1", "uniprot_id": "IRC20_YEAST", "mass": 180344.0, "length": 1556, "protein_name": "ATP-dependent DNA repair protein/ubiquitin-protein ligase E3 IRC20", "gene_name": "IRC20", "organism": "Yeast", "refseq_name": "E3 ubiquitin-protein ligase IRC20", "refseq_ac": "NP_013348", "gene_names_uniprotkb": "IRC20", "gene_names_refseq": "IRC20", "protein_names_uniprotkb": "ATP-dependent DNA repair protein/ubiquitin-protein ligase E3 IRC20; 2.3.2.27; 3.6.4.-; Increased recombination centers protein 20", "protein_names_refseq": "E3 ubiquitin-protein ligase IRC20", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR247C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10077188;14562095;14562106;18085829;18407956;19779198;22814378;23749301;24155900;24374639;32597660;33202365;33229814;33491328;9169871", "class_list": "", "function": "Directs homologous recombination (HR)-mediated double-strand break (DSB) repair towards the synthesis dependent strand annealing (SDSA) pathway (PubMed:33202365). Promotes the loading of RAD51 to ssDNA during DSB repair, and limits the accumulation of RAD52 (PubMed:33202365). Both its ATPase and ubiquitin ligase activities are required for its involvement in DNA repair (PubMed:24155900, PubMed:33202365). Binds DNA and nucleosomes; DNA-binding does not stimulate its ATPase activity and the protein does not appear to remodel nucleosomes (PubMed:33202365)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VYP5", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0045003 double-strand break repair via synthesis-dependent strand annealing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q06554-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06593-1", "uniprot_id": "OPT2_YEAST", "mass": 101261.0, "length": 877, "protein_name": "Oligopeptide transporter 2", "gene_name": "OPT2", "organism": "Yeast", "refseq_name": "Opt2p", "refseq_ac": "NP_015520", "gene_names_uniprotkb": "OPT2; P9677.13", "gene_names_refseq": "OPT2", "protein_names_uniprotkb": "Oligopeptide transporter 2", "protein_names_refseq": "Opt2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR194C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10788431;16847258;24374639;9169875;9643541", "class_list": "", "function": "Transports tetra- and pentapeptides. Does not transport glutathione., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W4J4", "ec_number_list": "", "go_molecular_function": "GO:0035673 oligopeptide transmembrane transporter activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005886 plasma membrane;GO:0000138 Golgi trans cisterna;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0042144 vacuole fusion, non-autophagic;GO:0015031 protein transport;GO:0045454 cell redox homeostasis;GO:0006857 oligopeptide transport;GO:0044088 regulation of vacuole organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q06593-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06596-1", "uniprot_id": "ARR1_YEAST", "mass": 33227.0, "length": 294, "protein_name": "Arsenical-resistance protein ARR1", "gene_name": "ARR1", "organism": "Yeast", "refseq_name": "Arr1p", "refseq_ac": "NP_015525", "gene_names_uniprotkb": "ARR1; ACR1; P9677.15; YAP8", "gene_names_refseq": "ACR1; ARR1; YAP8", "protein_names_uniprotkb": "Arsenical-resistance protein ARR1; AP-1-like transcription factor YAP8; Arsenic compound resistance protein 1", "protein_names_refseq": "Arr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR199C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11442837;11527213;15147884;17200139;17322287;24374639;26711267;31772124;9169875;9234670;9372930", "class_list": "", "function": "Transcription activator required for resistance to arsenic compounds and for a regulated expression of ACR2, ACR3 and YCF1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4J7", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071243 cellular response to arsenic-containing substance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q06596-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06598-1", "uniprot_id": "ARR3_YEAST", "mass": 45848.0, "length": 404, "protein_name": "Arsenical-resistance protein 3", "gene_name": "ARR3", "organism": "Yeast", "refseq_name": "Arr3p", "refseq_ac": "NP_015527", "gene_names_uniprotkb": "ARR3; ACR3; P9677.2", "gene_names_refseq": "ACR3; ARR3", "protein_names_uniprotkb": "Arsenical-resistance protein 3; Arsenic compounds resistance protein 3; As(III)/H(+) and Sb(III)/H(+)antiporter", "protein_names_refseq": "Arr3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR201W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "20655873;21447319;22107880;22380876;24291645;24374639;26123064;33491328;9169875;9234670;9374482", "class_list": "", "function": "Plasma membrane transporter that confers resistance to toxic metalloids by mediating extrusion of arsenite (As(III)) and antimonite (Sb(III)) out of cells. Displays low-affinity As(III)/H(+) and Sb(III)/H(+) exchange activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W4J9", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0015105 arsenite transmembrane transporter activity;GO:0015104 antimonite transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006811 monoatomic ion transport;GO:0015699 antimonite transmembrane transport;GO:0015700 arsenite transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q06598-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06623-1", "uniprot_id": "HDA3_YEAST", "mass": 75463.0, "length": 655, "protein_name": "HDA1 complex subunit 3", "gene_name": "HDA3", "organism": "Yeast", "refseq_name": "Hda3p", "refseq_ac": "NP_015505", "gene_names_uniprotkb": "HDA3; PLO1", "gene_names_refseq": "HDA3; PLO1", "protein_names_uniprotkb": "HDA1 complex subunit 3; Histone deacetylase complex 1 subunit 3", "protein_names_refseq": "Hda3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR179C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11287668;14562095;14562106;21126336;23749301;24374639;32597660;33481703;33491328;8663039;9169875", "class_list": "", "function": "Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4H9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0140750 nucleosome array spacer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070823 HDA1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q06623-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06625-1", "uniprot_id": "GDE_YEAST", "mass": 174972.0, "length": 1536, "protein_name": "Glycogen debranching enzyme", "gene_name": "GDB1", "organism": "Yeast", "refseq_name": "bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase", "refseq_ac": "NP_015510", "gene_names_uniprotkb": "GDB1", "gene_names_refseq": "GDB1", "protein_names_uniprotkb": "Glycogen debranching enzyme; Dextrin 6-alpha-D-glucosidase; Glycogen debrancher; Oligo-1,4-1,4-glucantransferase", "protein_names_refseq": "bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase", "tax_id": 559292, "disease": "glycogen storage disease III (Disease Ontology:DOID:2748); uremia (Disease Ontology:DOID:4676); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (sce:YPR184W); (R-SCE-6798695); (R-SCE-70221)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10873545;11094287;14562095;14562106;17761666;21585652;24374639;33491328;9169875", "class_list": "", "function": "Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4I4;O93808", "ec_number_list": "", "go_molecular_function": "GO:0004134 4-alpha-glucanotransferase activity;GO:0004135 amylo-alpha-1,6-glucosidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0005978 glycogen biosynthetic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q06625-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06629-1", "uniprot_id": "HDA2_YEAST", "mass": 77059.0, "length": 674, "protein_name": "HDA1 complex subunit 2", "gene_name": "HDA2", "organism": "Yeast", "refseq_name": "Hda2p", "refseq_ac": "NP_010581", "gene_names_uniprotkb": "HDA2; PLO2", "gene_names_refseq": "HDA2; PLO2", "protein_names_uniprotkb": "HDA1 complex subunit 2; Histone deacetylase complex 1 subunit 2", "protein_names_refseq": "Hda2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR295C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11287668;14562095;14562106;24374639;33491328;33502312;8663039;9169867", "class_list": "", "function": "Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSS4", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070823 HDA1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06629-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06630-1", "uniprot_id": "MHR1_YEAST", "mass": 26895.0, "length": 226, "protein_name": "Large ribosomal subunit protein mL67", "gene_name": "MHR1", "organism": "Yeast", "refseq_name": "mitochondrial 54S ribosomal protein mL67 MHR1", "refseq_ac": "NP_010582", "gene_names_uniprotkb": "MHR1; XTC1", "gene_names_refseq": "MHR1; XTC1; mL67", "protein_names_uniprotkb": "Large ribosomal subunit protein mL67; Cross-linked transcription component 1; Mitochondrial homologous recombination protein 1", "protein_names_refseq": "mitochondrial 54S ribosomal protein mL67 MHR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR296W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11121487;12034822;12198175;14562095;14562106;14565971;14576278;16337661;17322287;22814378;23749301;24374639;24675956;25609543;33481703;33491328;7664749;9169867;9736700", "class_list": "", "function": "Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543). mL67/MHR1 also has extraribosomal functions, being involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (PubMed:11121487, PubMed:12198175, PubMed:14565971, PubMed:16337661, PubMed:7664749, PubMed:9736700). mL67/MHR1 also acts as transcription factor involved in regulation of RNA polymerase II-dependent transcription (PubMed:12034822)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSS5", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003697 single-stranded DNA binding;GO:0000150 DNA strand exchange activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0090297 positive regulation of mitochondrial DNA replication;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q06630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06651-1", "uniprot_id": "PIB1_YEAST", "mass": 32675.0, "length": 286, "protein_name": "E3 ubiquitin-protein ligase PIB1", "gene_name": "PIB1", "organism": "Yeast", "refseq_name": "phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase", "refseq_ac": "NP_010599", "gene_names_uniprotkb": "PIB1", "gene_names_refseq": "PIB1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PIB1; 2.3.2.27; Phosphatidylinositol 3-phosphate-binding protein 1; RING-type E3 ubiquitin transferase PIB1", "protein_names_refseq": "phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR313C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11526110;14562095;14562106;17322287;22814378;23749301;24374639;33481703;33491328;9169867;9702203", "class_list": "", "function": "Functions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSU2;Q6Q5S5", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005770 late endosome;GO:0010008 endosome membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0016567 protein ubiquitination;GO:0045721 negative regulation of gluconeogenesis;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q06651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06671-1", "uniprot_id": "ATG23_YEAST", "mass": 51540.0, "length": 453, "protein_name": "Autophagy-related protein 23", "gene_name": "ATG23", "organism": "Yeast", "refseq_name": "Atg23p", "refseq_ac": "NP_013535", "gene_names_uniprotkb": "ATG23; CVT23", "gene_names_refseq": "ATG23; CVT23", "protein_names_uniprotkb": "Autophagy-related protein 23; Cytoplasm to vacuole targeting protein 23", "protein_names_refseq": "Atg23p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR431C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14504273;14536056;14562106;14723849;14734026;17426440;17700056;18497569;19795423;19823750;24374639;33481703;33491328;34965436;9169871", "class_list": "", "function": "Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Also plays a role in regulation of filamentous growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ66", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0016239 positive regulation of macroautophagy;GO:0034497 protein localization to phagophore assembly site;GO:0044804 nucleophagy;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q06671-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06675-1", "uniprot_id": "CENPO_YEAST", "mass": 42971.0, "length": 368, "protein_name": "Inner kinetochore subunit MCM21", "gene_name": "MCM21", "organism": "Yeast", "refseq_name": "Mcm21p", "refseq_ac": "NP_010604", "gene_names_uniprotkb": "MCM21; CTF5", "gene_names_refseq": "CTF5; MCM21", "protein_names_uniprotkb": "Inner kinetochore subunit MCM21; CENP-O homolog; Chromosome transmission fidelity protein 5; Constitutive centromere-associated network protein MCM21; Minichromosome maintenance protein 21", "protein_names_refseq": "Mcm21p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR318W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10323865;12408861;14562095;14562106;14633972;17322287;18407956;22561346;23749301;24374639;29046335;33481703;33491328;34308839;9169867;9987135", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSU9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000817 COMA complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0071459 protein localization to chromosome, centromeric region;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q06675-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06676-1", "uniprot_id": "YFT2_YEAST", "mass": 32011.0, "length": 274, "protein_name": "Acyl-coenzyme A diphosphatase YFT2", "gene_name": "YFT2", "organism": "Yeast", "refseq_name": "Yft2p", "refseq_ac": "NP_010605", "gene_names_uniprotkb": "YFT2; FIT2A", "gene_names_refseq": "FIT2A; YFT2", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase YFT2; 3.6.1.-; FIT family protein YFT2", "protein_names_refseq": "Yft2p", "tax_id": 559292, "disease": "Siddiqi syndrome (Disease Ontology:DOID:0081273); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (sce:YDR319C); (R-SCE-8964572)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16847258;24374639;26504167;29417057;29526591;9169867", "class_list": "", "function": "Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PubMed:26504167). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity) (PubMed:29526591). May play a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Involved in phospholipid biosynthesis (By similarity) (PubMed:29417057)., [UniProtKB, UniProtKB, HAMAP, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSV0", "ec_number_list": "3.6.1.-", "go_molecular_function": "GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0005773 vacuole", "go_biological_process": "GO:0019915 lipid storage;GO:0034389 lipid droplet organization;GO:0008654 phospholipid biosynthetic process;GO:0140042 lipid droplet formation;GO:0036115 fatty-acyl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06676-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06677-1", "uniprot_id": "SWA2_YEAST", "mass": 75020.0, "length": 668, "protein_name": "Auxilin-like clathrin uncoating factor SWA2", "gene_name": "SWA2", "organism": "Yeast", "refseq_name": "auxilin-like protein SWA2", "refseq_ac": "NP_010606", "gene_names_uniprotkb": "SWA2; AUX1; BUD24; D9798.10", "gene_names_refseq": "AUX1; BUD24; SWA2", "protein_names_uniprotkb": "Auxilin-like clathrin uncoating factor SWA2; Bud site selection protein 24; DnaJ-related protein SWA2; J protein SWA2; Synthetic lethal with ARF1 protein 2", "protein_names_refseq": "auxilin-like protein SWA2", "tax_id": 559292, "disease": "Parkinson's disease 19A (Disease Ontology:DOID:0060891); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YDR320C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "11084334;11146663;11553703;14562106;14997574;16687570;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Cofactor for the uncoating of clathrin-coated vesicles (CCVs) by Hsp70-type chaperones (SSA1/2/3 and SSB1/2). Coat disassembly is important for fusion of vesicles with target membranes and for recycling components of clathrin coats to the cytoplasm for further rounds of vesicle formation. Binds to assembled clathrin and recruits the ATP-activated chaperone to CCVs. Stimulates the ATPase activity of the clathrin-associated Hsp70-type chaperone SSA1, which then disrupts clathrin-clathrin interactions, leading to release of the clathrin coat. In addition, prevents unproductive clathrin assembly in the cell. Also required for cortical endoplasmic reticulum inheritance., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSV1", "ec_number_list": "", "go_molecular_function": "GO:0030276 clathrin binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0031982 vesicle", "go_biological_process": "GO:0072583 clathrin-dependent endocytosis;GO:0072318 clathrin coat disassembly;GO:0048309 endoplasmic reticulum inheritance", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q06677-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06681-1", "uniprot_id": "YSP2_YEAST", "mass": 160578.0, "length": 1438, "protein_name": "Membrane-anchored lipid-binding protein YSP2", "gene_name": "YSP2", "organism": "Yeast", "refseq_name": "Ysp2p", "refseq_ac": "NP_010613", "gene_names_uniprotkb": "YSP2; LAM2; LTC4", "gene_names_refseq": "LAM2; LTC4; YSP2", "protein_names_uniprotkb": "Membrane-anchored lipid-binding protein YSP2; Lipid transfer at contact site protein 4; Lipid transfer protein anchored at membrane contact sites 3; Yeast suicide protein 2", "protein_names_refseq": "Ysp2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR326C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "16962064;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;24909858;25987606;26001273;29927351;31208443;32597660;33255682;33481703;33491328;34965436;9169867", "class_list": "", "function": "Involved in induction of programmed cell death in response to reactive oxygen species (ROS) (PubMed:16962064). May be involved in sterol transfer between intracellular membranes (PubMed:26001273)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 52, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VSV9", "ec_number_list": "", "go_molecular_function": "GO:0032934 sterol binding;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0006915 apoptotic process;GO:0015918 sterol transport", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q06681-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06685-1", "uniprot_id": "VIP1_YEAST", "mass": 129755.0, "length": 1146, "protein_name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase", "gene_name": "VIP1", "organism": "Yeast", "refseq_name": "inositol polyphosphate kinase VIP1", "refseq_ac": "NP_013514", "gene_names_uniprotkb": "VIP1", "gene_names_refseq": "VIP1", "protein_names_uniprotkb": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; 2.7.4.24; InsP6 and PP-IP5 kinase", "protein_names_refseq": "inositol polyphosphate kinase VIP1", "tax_id": 559292, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); autosomal recessive nonsyndromic deafness 100 (Disease Ontology:DOID:0111638); keratoconus (Disease Ontology:DOID:10126)", "pathway": " (sce:YLR410W); (R-SCE-1855167)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10388810;14562095;14562106;15665377;17330950;17412958;17412959;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;9169871", "class_list": "", "function": "Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17412958). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity). Required for maintaining cellular integrity, normal growth and interactions with the ARP complex (PubMed:10388810). Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability (PubMed:17412959). Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth (PubMed:10388810). Regulates polarized growth and modulates interphase microtubule cytoskeleton. Regulates microtubule dynamics without the requirement of microtubule plus-end tracking protein Mal3. Required for growth zone selection (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ44", "ec_number_list": "2.7.4.24", "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0000829 diphosphoinositol pentakisphosphate kinase activity;GO:0052723 inositol hexakisphosphate 1-kinase activity;GO:0052724 inositol hexakisphosphate 3-kinase activity;GO:0000831 inositol hexakisphosphate 6-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0070507 regulation of microtubule cytoskeleton organization;GO:0030643 intracellular phosphate ion homeostasis;GO:0032958 inositol phosphate biosynthetic process;GO:0051516 regulation of bipolar cell growth", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q06685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06703-1", "uniprot_id": "CDA2_YEAST", "mass": 35693.0, "length": 312, "protein_name": "Chitin deacetylase 2", "gene_name": "CDA2", "organism": "Yeast", "refseq_name": "chitin deacetylase CDA2", "refseq_ac": "NP_013411", "gene_names_uniprotkb": "CDA2; L2142.1", "gene_names_refseq": "CDA2", "protein_names_uniprotkb": "Chitin deacetylase 2; 3.5.1.41", "protein_names_refseq": "chitin deacetylase CDA2", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR308W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11812231;17322287;24374639;9133736;9169871", "class_list": "", "function": "Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate (PubMed:11812231, PubMed:9133736). Chitosan is a component of the spore wall (PubMed:9133736)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D6VYV2", "ec_number_list": "3.5.1.41", "go_molecular_function": "GO:0050897 cobalt ion binding;GO:0008061 chitin binding;GO:0004099 chitin deacetylase activity", "go_cellular_component": "GO:0042764 ascospore-type prospore", "go_biological_process": "GO:0000272 polysaccharide catabolic process;GO:0006032 chitin catabolic process;GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q06703-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06705-1", "uniprot_id": "CSR1_YEAST", "mass": 47463.0, "length": 408, "protein_name": "Phosphatidylinositol transfer protein CSR1", "gene_name": "CSR1", "organism": "Yeast", "refseq_name": "Csr1p", "refseq_ac": "NP_013484", "gene_names_uniprotkb": "CSR1; SFH2", "gene_names_refseq": "CSR1; SFH2", "protein_names_uniprotkb": "Phosphatidylinositol transfer protein CSR1; CHS5 SPA2 rescue protein 1; SEC14 homolog protein 2", "protein_names_refseq": "Csr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR380W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10679005;10848624;12435498;12824182;12869188;14562106;15665377;16126894;16262726;17322287;17803462;23749301;24374639;27821475;33491328;9169871", "class_list": "", "function": "Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress. Inhibits fatty acid synthase activity in response to heme depletion and oleic acid starvation, preventing saturated fatty acid (SFA) accumulation (PubMed:17803462)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ15;Q6B265", "ec_number_list": "", "go_molecular_function": "GO:0008526 phosphatidylinositol transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005628 prospore membrane", "go_biological_process": "GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0009395 phospholipid catabolic process;GO:0015914 phospholipid transport;GO:2001247 positive regulation of phosphatidylcholine biosynthetic process;GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q06705-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06817-1", "uniprot_id": "SYG2_YEAST", "mass": 71018.0, "length": 618, "protein_name": "Glycine--tRNA ligase 2", "gene_name": "GRS2", "organism": "Yeast", "refseq_name": "putative glycine--tRNA ligase", "refseq_ac": "NP_015406", "gene_names_uniprotkb": "GRS2", "gene_names_refseq": "GRS2", "protein_names_uniprotkb": "Glycine--tRNA ligase 2; 2.7.7.-; 6.1.1.14; Ap4A synthetase; Diadenosine tetraphosphate synthetase; GlyRS 2; GlyRS2; Glycyl-tRNA synthetase 2", "protein_names_refseq": "putative glycine--tRNA ligase", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 2D (Disease Ontology:DOID:0110164); autosomal dominant distal hereditary motor neuronopathy 5 (Disease Ontology:DOID:0111203); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (sce:YPR081C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10874035;14562095;14562106;22814378;23816885;24374639;33491328;9169875", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:23816885). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W483", "ec_number_list": "2.7.7.-;6.1.1.14", "go_molecular_function": "GO:0005524 ATP binding;GO:0046983 protein dimerization activity;GO:0004820 glycine-tRNA ligase activity;GO:0141192 ATP:ATP adenylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0015966 diadenosine tetraphosphate biosynthetic process;GO:0070150 mitochondrial glycyl-tRNA aminoacylation;GO:0006426 glycyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06819-1", "uniprot_id": "DIB1_YEAST", "mass": 16776.0, "length": 143, "protein_name": "Spliceosomal protein DIB1", "gene_name": "DIB1", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit DIB1", "refseq_ac": "NP_015407", "gene_names_uniprotkb": "DIB1; CDH1; P9513.12; SNU16", "gene_names_refseq": "DIB1; SNU16", "protein_names_uniprotkb": "Spliceosomal protein DIB1", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit DIB1", "tax_id": 559292, "disease": "Burn-McKeown syndrome (Disease Ontology:DOID:0080695); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YPR082C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10449419;17322287;22814378;24374639;9169875;9182666", "class_list": "", "function": "Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W484", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0005682 U5 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06819-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06836-1", "uniprot_id": "SYT1_YEAST", "mass": 137583.0, "length": 1226, "protein_name": "Arf guanine nucleotide exchange factor SYT1", "gene_name": "SYT1", "organism": "Yeast", "refseq_name": "Arf family guanine nucleotide exchange factor SYT1", "refseq_ac": "NP_015420", "gene_names_uniprotkb": "SYT1; P9513.17", "gene_names_refseq": "SYT1", "protein_names_uniprotkb": "Arf guanine nucleotide exchange factor SYT1; Arf-GEF SYT1; Suppressor of YPT3 protein 1", "protein_names_refseq": "Arf family guanine nucleotide exchange factor SYT1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR095C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10430582;14562106;15023338;15665377;17287358;17330950;17563356;18407956;19684113;19779198;20702584;21177495;22218487;23749301;24374639;32597660;33229814;33481703;33491328;9169875", "class_list": "", "function": "Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Catalyzes both the GDP release by and the GTP binding to ARF2. Has no exchange activity on Rab GTPases. Involved in vesicular transport., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 22, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 22, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 22, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "D6W494", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0006887 exocytosis;GO:0034067 protein localization to Golgi apparatus;GO:0034976 response to endoplasmic reticulum stress;GO:0032014 positive regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q06836-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07350-1", "uniprot_id": "PRP11_YEAST", "mass": 29921.0, "length": 266, "protein_name": "Pre-mRNA-splicing factor PRP11", "gene_name": "PRP11", "organism": "Yeast", "refseq_name": "spliceosome assembly protein PRP11", "refseq_ac": "NP_010241", "gene_names_uniprotkb": "PRP11; D2711; PRP10; RNA11", "gene_names_refseq": "PRP11; RNA11", "protein_names_uniprotkb": "Pre-mRNA-splicing factor PRP11", "protein_names_refseq": "spliceosome assembly protein PRP11", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL043C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11884590;14562106;18407956;21126336;23749301;24374639;33481703;33491328;9046088;9169867;9710584", "class_list": "", "function": "mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for addition of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRV3;Q05434", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q07350-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07381-1", "uniprot_id": "TSR1_YEAST", "mass": 90748.0, "length": 788, "protein_name": "Ribosome biogenesis protein TSR1", "gene_name": "TSR1", "organism": "Yeast", "refseq_name": "small subunit rRNA maturation protein TSR1", "refseq_ac": "NP_010223", "gene_names_uniprotkb": "TSR1", "gene_names_refseq": "TSR1", "protein_names_uniprotkb": "Ribosome biogenesis protein TSR1; 20S rRNA accumulation protein 1", "protein_names_refseq": "small subunit rRNA maturation protein TSR1", "tax_id": 559292, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040)", "pathway": " (sce:YDL060W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11565749;12628929;14562106;15167894;16159874;23749301;24374639;32138239;33481703;33491328;8769646;9169867", "class_list": "", "function": "Required for 40S ribosomal subunit synthesis. Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunitshifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRT6;Q03128", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q07381-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07418-1", "uniprot_id": "PEX19_YEAST", "mass": 38706.0, "length": 342, "protein_name": "Peroxisomal membrane protein import receptor PEX19", "gene_name": "PEX19", "organism": "Yeast", "refseq_name": "Pex19p", "refseq_ac": "NP_010218", "gene_names_uniprotkb": "PEX19; D2528; PAS12", "gene_names_refseq": "PAS12; PEX19", "protein_names_uniprotkb": "Peroxisomal membrane protein import receptor PEX19; Peroxin-19", "protein_names_refseq": "Pex19p", "tax_id": 559292, "disease": "peroxisome biogenesis disorder 12A (Disease Ontology:DOID:0080486); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (sce:YDL065C); (R-SCE-1369062); (R-SCE-9603798)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "10637226;12748633;12775844;12876220;14562095;14562106;14690591;15133130;16009135;16087670;16520372;16551610;16679311;16791427;17330950;18407956;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169867;9418908", "class_list": "", "function": "Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer. Directs PEX17, a peripheral component of the peroxisomal matrix protein translocation machinery, to peroxisomes. Stabilizes VPS1, a protein required for peroxisomal fission, at the peroxisomal membrane. Also acts in conjunction with PEX3 in the formation of peroxisomes from preperoxisomal compartments at the endoplasmic reticulum during de novo peroxisome synthesis, probably via the import of additional PMPs., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRT2", "ec_number_list": "", "go_molecular_function": "GO:0033328 peroxisome membrane targeting sequence binding", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0032581 ER-dependent peroxisome organization;GO:0045046 protein import into peroxisome membrane;GO:0032527 protein exit from endoplasmic reticulum;GO:0045033 peroxisome inheritance", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q07418-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07471-1", "uniprot_id": "THI3_YEAST", "mass": 68366.0, "length": 609, "protein_name": "Thiamine metabolism regulatory protein THI3", "gene_name": "THI3", "organism": "Yeast", "refseq_name": "branched-chain-2-oxoacid decarboxylase THI3", "refseq_ac": "NP_010203", "gene_names_uniprotkb": "THI3; KID1", "gene_names_refseq": "KID1; THI3", "protein_names_uniprotkb": "Thiamine metabolism regulatory protein THI3; 2ODC; 4.1.1.72; Keto isocaproate decarboxylase 1; Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase", "protein_names_refseq": "branched-chain-2-oxoacid decarboxylase THI3", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL080C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10753893;12499363;12902239;14562095;14562106;1624458;18407956;22904058;23749301;24374639;33491328;9169867;9341119;9748245", "class_list": "", "function": "One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) involved in amino acid catabolism. The enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids (alpha-keto-acids). In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids derived from leucine (4-methyl-2-oxopentanoate, also alpha-keto-isocaproate) and isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), whereas transaminated valine, transaminated aromatic amino acids, and pyruvate are no substrates. In analogy to the pyruvate decarboxylases the enzyme may in a side-reaction catalyze condensation (or carboligation) reactions leading to the formation of 2-hydroxy ketone, collectively called acyloins. The enzyme is also positively regulating the thiamine metabolism by a molecular mechanism that may involve thiamine concentration sensing and signal transmission., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRR9;P89098", "ec_number_list": "4.1.1.-;4.1.1.43;4.1.1.72;4.1.1.74;4.1.1.80", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0030976 thiamine pyrophosphate binding;GO:0047433 branched-chain-2-oxoacid decarboxylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009083 branched-chain amino acid catabolic process;GO:0000955 amino acid catabolic process via Ehrlich pathway;GO:0090180 positive regulation of thiamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q07471-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07478-1", "uniprot_id": "SUB2_YEAST", "mass": 50309.0, "length": 446, "protein_name": "ATP-dependent RNA helicase SUB2", "gene_name": "SUB2", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase SUB2", "refseq_ac": "NP_010199", "gene_names_uniprotkb": "SUB2", "gene_names_refseq": "SUB2", "protein_names_uniprotkb": "ATP-dependent RNA helicase SUB2; 3.6.4.13; Suppressor of BRR1 protein 2", "protein_names_refseq": "ATP-dependent RNA helicase SUB2", "tax_id": 559292, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (sce:YDL084W)", "pathway_count": 1, "publication_count": 37, "publication_id_list": "10077188;11156602;11156603;11156604;11463828;11675790;11696331;11979277;12034490;12093753;12411502;12417727;12871933;14562095;14562106;15665377;15942929;17287358;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22106047;22218487;23749301;24374639;32597660;33481703;33491328;37578863;9169867", "class_list": "", "function": "ATP-binding RNA helicase component of the TREX complex involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Associates with THO1, which facilitates RNA binding of SUB2 and likely plays a role in mRNA export (PubMed:37578863)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRR5", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0000346 transcription export complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006406 mRNA export from nucleus;GO:0006368 transcription elongation by RNA polymerase II;GO:0000398 mRNA splicing, via spliceosome;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q07478-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07508-1", "uniprot_id": "LUC7_YEAST", "mass": 30195.0, "length": 261, "protein_name": "Protein LUC7", "gene_name": "LUC7", "organism": "Yeast", "refseq_name": "Luc7p", "refseq_ac": "NP_010196", "gene_names_uniprotkb": "LUC7; EPE1; EXM2", "gene_names_refseq": "EPE1; EXM2; LUC7", "protein_names_uniprotkb": "Protein LUC7", "protein_names_refseq": "Luc7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL087C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10449419;10500099;10533282;11804584;14562095;14562106;22814378;24374639;9169867", "class_list": "", "function": "Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRR1", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006376 mRNA splice site recognition;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q07508-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07532-1", "uniprot_id": "IWR1_YEAST", "mass": 40640.0, "length": 353, "protein_name": "RNA polymerase II nuclear localization protein IWR1", "gene_name": "IWR1", "organism": "Yeast", "refseq_name": "Iwr1p", "refseq_ac": "NP_010168", "gene_names_uniprotkb": "IWR1", "gene_names_refseq": "IWR1", "protein_names_uniprotkb": "RNA polymerase II nuclear localization protein IWR1; Interacting with RNA polymerase II protein 1", "protein_names_refseq": "Iwr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL115C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12663529;14562095;14562106;16554755;17101987;17244705;17322287;19679657;19684113;20010803;21504834;22814378;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Directs RNA polymerase II nuclear import. Binds RNA polymerase II in the active center cleft between the two largest subunits in the cytoplasm. Then uses an N-terminal bipartite nuclear localization signal that may be recognized by karyopherin alpha to direct the polymerase II complex nuclear import. In the nucleus, is displaced from polymerase II complex by transcription initiation factors and nucleic acids, enabling its export and recycling., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBP4;D6VRN5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q07532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07551-1", "uniprot_id": "KAR_YEAST", "mass": 35561.0, "length": 312, "protein_name": "NADPH-dependent alpha-keto amide reductase", "gene_name": "D2240", "organism": "Yeast", "refseq_name": "aldo-keto reductase superfamily protein", "refseq_ac": "NP_010159", "gene_names_uniprotkb": "D2240", "gene_names_refseq": "", "protein_names_uniprotkb": "NADPH-dependent alpha-keto amide reductase; 1.2.1.-; AKR-E; YKAR", "protein_names_refseq": "aldo-keto reductase superfamily protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL124W); (R-SCE-193144); (R-SCE-193368); (R-SCE-193775); (R-SCE-193807); (R-SCE-196108); (R-SCE-2162123); (R-SCE-5365859); (R-SCE-5652227); (R-SCE-70221); (R-SCE-9757110)", "pathway_count": 11, "publication_count": 12, "publication_id_list": "11306085;12627397;14562095;14562106;15564669;17330950;18407956;23749301;24374639;33481703;33491328;9169867", "class_list": "", "function": "Reduces aromatic alpha-keto amides, aliphatic and aromatic alpha-keto esters, but not beta-keto esters., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRM6", "ec_number_list": "1.1.1.156;1.1.1.117;1.-.-.-;1.2.1.-;1.1.1.2", "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0016652 oxidoreductase activity, acting on NAD(P)H as acceptor;GO:0051268 alpha-keto amide reductase activity;GO:0051269 alpha-ketoester reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q07551-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07560-1", "uniprot_id": "CRLS1_YEAST", "mass": 32020.0, "length": 283, "protein_name": "Cardiolipin synthase (CMP-forming)", "gene_name": "CRD1", "organism": "Yeast", "refseq_name": "cardiolipin synthase", "refseq_ac": "NP_010139", "gene_names_uniprotkb": "CRD1; CLS1", "gene_names_refseq": "CLS1; CRD1", "protein_names_uniprotkb": "Cardiolipin synthase (CMP-forming); 2.7.8.41; CLS", "protein_names_refseq": "cardiolipin synthase", "tax_id": 559292, "disease": "combined oxidative phosphorylation deficiency 57 (Disease Ontology:DOID:0070430)", "pathway": " (sce:YDL142C); (R-SCE-1482925); (R-SCE-1483076)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "14562106;21177495;2171667;24374639;26793177;29167800;9169867;9370334;9442089;9462830;9614098", "class_list": "", "function": "Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG) (PubMed:2171667, PubMed:26793177, PubMed:29167800, PubMed:9370334). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions (PubMed:9370334)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRK6;P82260", "ec_number_list": "2.7.8.41", "go_molecular_function": "GO:0043337 cardiolipin synthase (CMP-forming)", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0006612 protein targeting to membrane;GO:0006644 phospholipid metabolic process;GO:0006873 intracellular monoatomic ion homeostasis;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q07560-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07648-1", "uniprot_id": "DTD_YEAST", "mass": 16746.0, "length": 150, "protein_name": "D-aminoacyl-tRNA deacylase", "gene_name": "DTD1", "organism": "Yeast", "refseq_name": "D-tyrosyl-tRNA(Tyr) deacylase", "refseq_ac": "NP_010062", "gene_names_uniprotkb": "DTD1", "gene_names_refseq": "DTD1", "protein_names_uniprotkb": "D-aminoacyl-tRNA deacylase; 3.1.1.96; D-tyrosyl-tRNA(Tyr) deacylase; DTD; Gly-tRNA(Ala) deacylase", "protein_names_refseq": "D-tyrosyl-tRNA(Tyr) deacylase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL219W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10766779;10918062;14562106;24374639;9169867", "class_list": "", "function": "An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs (Probable). Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr) (PubMed:10766779). May also deacylate mischarged D-leucyl-tRNA(Leu) (PubMed:10918062). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By similarity). Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRD5", "ec_number_list": "3.1.1.96", "go_molecular_function": "GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0000049 tRNA binding;GO:0106026 Gly-tRNA(Ala) deacylase activity;GO:0097358 D-leucyl-tRNA(Leu) deacylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006399 tRNA metabolic process;GO:1900829 D-tyrosine catabolic process;GO:1900832 D-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07648-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07732-1", "uniprot_id": "ADY3_YEAST", "mass": 91812.0, "length": 790, "protein_name": "Accumulates dyads protein 3", "gene_name": "ADY3", "organism": "Yeast", "refseq_name": "Ady3p", "refseq_ac": "NP_010042", "gene_names_uniprotkb": "ADY3", "gene_names_refseq": "ADY3", "protein_names_uniprotkb": "Accumulates dyads protein 3", "protein_names_refseq": "Ady3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL239C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11742972;11973299;24374639;9169867", "class_list": "", "function": "Involved in the pathway that organizes the prospore membrane (PSM) during sporulation. Mediates the assembly of the DON1 ring structure at the leading edge of PSM during meiosis II. May constitute a physical link between SSP1-containing PSM precursors and the spindle pole body (SPB) and may facilitate the recruitment of other factors that are required to promote spore wall formation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRB7", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0000793 condensed chromosome;GO:0000785 chromatin;GO:0000796 condensin complex;GO:0005816 spindle pole body", "go_biological_process": "GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0000001 mitochondrion inheritance;GO:0030435 sporulation resulting in formation of a cellular spore;GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q07732-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07791-1", "uniprot_id": "YD23B_YEAST", "mass": 201962.0, "length": 1770, "protein_name": "Transposon Ty2-DR3 Gag-Pol polyprotein", "gene_name": "TY2B-DR3", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058146", "gene_names_uniprotkb": "TY2B-DR3; YD9320A.14; YDRWTy2-3 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty2-DR3 Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR261W-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;24374639;33229814;9169867;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VSP2;Q03934", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q07791-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07793-1", "uniprot_id": "YD13B_YEAST", "mass": 181661.0, "length": 1604, "protein_name": "Transposon Ty1-DR4 Gag-Pol polyprotein", "gene_name": "TY1B-DR4", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058148", "gene_names_uniprotkb": "TY1B-DR4; YDRCTy1-3 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-DR4 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR261C-D)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15665377;16093660;16093680;17287358;18407956;19779198;24374639;9169867;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VSP4", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q07793-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07804-1", "uniprot_id": "YEH1_YEAST", "mass": 66508.0, "length": 573, "protein_name": "Sterol esterase 1", "gene_name": "YEH1", "organism": "Yeast", "refseq_name": "sterol esterase", "refseq_ac": "NP_013089", "gene_names_uniprotkb": "YEH1; L1329", "gene_names_refseq": "YEH1", "protein_names_uniprotkb": "Sterol esterase 1; 3.1.1.13; Steryl ester hydrolase 1", "protein_names_refseq": "sterol esterase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL012W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;15713625;16835446;21126336;23749301;24374639;33491328;9169871", "class_list": "", "function": "Mediates the hydrolysis of steryl esters, thereby playing a central role in lipid metabolism. Under heme-deficient conditions, it constitutes the major steryl ester hydrolase, suggesting that it plays a central role in mobilization of steryl esters under anaerobic conditions., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXZ0", "ec_number_list": "3.1.1.13", "go_molecular_function": "GO:0004771 sterol ester esterase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0016125 sterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q07804-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07807-1", "uniprot_id": "PUF3_YEAST", "mass": 98068.0, "length": 879, "protein_name": "mRNA-binding protein PUF3", "gene_name": "PUF3", "organism": "Yeast", "refseq_name": "mRNA-binding protein PUF3", "refseq_ac": "NP_013088", "gene_names_uniprotkb": "PUF3; L1325", "gene_names_refseq": "PUF3", "protein_names_uniprotkb": "mRNA-binding protein PUF3; Pumilio homology domain family member 3", "protein_names_refseq": "mRNA-binding protein PUF3", "tax_id": 559292, "disease": "cerebellar ataxia type 47 (Disease Ontology:DOID:0111743); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YLL013C)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "11101532;12730603;14562095;14562106;15024427;15337848;15665377;16244132;16355254;17210948;17563356;18094119;18407956;18523582;19684113;19779198;19795423;19823750;20489023;20702584;21177495;23749301;24374639;27821475;30516470;32597660;33229814;33481703;33491328;33655635;8810043;9046100;9169871", "class_list": "", "function": "RNA-binding protein involved in post-transcriptional regulation. Negatively regulates expression of COX17 by binding to the 3'-UTR of COX17 mRNA. Promotes decay of COX17 mRNA by enhancing its rate of deadenylation and subsequent turnover. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 34, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 34, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 34, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 33, "binding_glycan_count": 0, "secondary_ac_list": "D6VXY9;Q02601", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032473 cytoplasmic side of mitochondrial outer membrane", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0045727 positive regulation of translation;GO:0007005 mitochondrion organization;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0051646 mitochondrion localization", "synthesized_glycan_count": 0, "hit_score": 6.9, "record_id": "Q07807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07824-1", "uniprot_id": "TPO1_YEAST", "mass": 64272.0, "length": 586, "protein_name": "Polyamine transporter 1", "gene_name": "TPO1", "organism": "Yeast", "refseq_name": "polyamine transporter TPO1", "refseq_ac": "NP_013072", "gene_names_uniprotkb": "TPO1; L0939", "gene_names_refseq": "TPO1", "protein_names_uniprotkb": "Polyamine transporter 1", "protein_names_refseq": "polyamine transporter TPO1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL028W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "11171066;11470516;11875433;12524434;12562762;13679573;14562095;14562106;15066780;15637075;16847258;17330950;17362938;18407956;19684113;19779198;20702584;21126336;22218487;23749301;24374639;27821475;32597660;33481703;33491328;9169871;9920864", "class_list": "", "function": "Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Catalyzes polyamine uptake at alkaline pH and excretion at acidic pH. Recognizes spermidine, spermine and putrescine, the polyamine analogs methylglyoxal bis(guanylhydrazone) (MGBG) and paraquat, the antimalarial drug quinidine, and cycloheximide. Confers resistance to the non-steroidal anti-inflammatory drug indomethacin., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXX6", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015606 spermidine transmembrane transporter activity;GO:0000297 spermine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000329 fungal-type vacuole membrane;GO:0033101 cellular bud membrane", "go_biological_process": "GO:0000296 spermine transport;GO:0055085 transmembrane transport;GO:0034599 cellular response to oxidative stress;GO:0015847 putrescine transport;GO:1902047 polyamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q07824-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07830-1", "uniprot_id": "GPI13_YEAST", "mass": 115634.0, "length": 1017, "protein_name": "GPI ethanolamine phosphate transferase 3", "gene_name": "GPI13", "organism": "Yeast", "refseq_name": "mannose-ethanolamine phosphotransferase GPI13", "refseq_ac": "NP_013069", "gene_names_uniprotkb": "GPI13; MPC1", "gene_names_refseq": "GPI13; MPC1", "protein_names_uniprotkb": "GPI ethanolamine phosphate transferase 3; 2.-.-.-; Glycosylphosphatidylinositol-anchor biosynthesis protein 13", "protein_names_refseq": "mannose-ethanolamine phosphotransferase GPI13", "tax_id": 559292, "disease": "hyperphosphatasia with impaired intellectual development syndrome 2 (Disease Ontology:DOID:0070434)", "pathway": " (sce:YLL031C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10487931;10793139;10823837;12441642;14562095;14562106;24374639;9169871", "class_list": "", "function": "Involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Involved in cell wall biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6VXX4", "ec_number_list": "", "go_molecular_function": "GO:0051377 mannose-ethanolamine phosphotransferase activity;GO:0016772 transferase activity, transferring phosphorus-containing groups", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07830-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07878-1", "uniprot_id": "VPS13_YEAST", "mass": 357849.0, "length": 3144, "protein_name": "Intermembrane lipid transfer protein VPS13", "gene_name": "VPS13", "organism": "Yeast", "refseq_name": "membrane morphogenesis protein VPS13", "refseq_ac": "NP_013060", "gene_names_uniprotkb": "VPS13; SOI1; VPT2; YME3", "gene_names_refseq": "SOI1; VPS13; VPT2; YME3", "protein_names_uniprotkb": "Intermembrane lipid transfer protein VPS13; Suppression of the onset of impotence protein 1; Vacuolar protein sorting-associated protein 13; Vacuolar protein-targeting protein 2", "protein_names_refseq": "membrane morphogenesis protein VPS13", "tax_id": 559292, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); choreaacanthocytosis (Disease Ontology:DOID:0050766); Parkinson's disease 23 (Disease Ontology:DOID:0060896); Cohen syndrome (Disease Ontology:DOID:0111590); autosomal recessive spinocerebellar ataxia 4 (Disease Ontology:DOID:0111611); choreatic disease (Disease Ontology:DOID:12859); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YLL040C)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "11875433;14562106;15665377;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22442115;22814378;23749301;24036347;24374639;26370498;27280386;28122955;28334785;28404745;28864540;30018089;30093493;32597660;32690699;33481703;33491328;34830155;34965436;9169871;9265642;9314526", "class_list": "", "function": "Mediates the transfer of lipids between membranes at organelle contact sites (PubMed:22442115, PubMed:24036347, PubMed:30093493). Binds phospholipids, including phosphatidic acid (PA), phosphorylated phosphatidylinositol (PI), phosphatidylcholine (PC), phosphatidylethanolamine (PE), ceramide, and phosphatidylserine (PS) (PubMed:28122955, PubMed:28334785, PubMed:30093493, PubMed:34830155). Involved in mitochondrial lipid homeostasis, in a MCP1-dependent manner (PubMed:27280386, PubMed:32690699, PubMed:34830155). Involved in cortical reticulophagy (also known as cortical endoplasmic reticulum (ER) macroautophagy), acting at the late endosome to package ER into autophagosomes (PubMed:32690699). Involved in the formation of the prospore membrane during sporulation, in a SPO71-dependent manner (PubMed:22442115, PubMed:24036347). Involved in Golgi vesicle transport, in a CDC31-dependent and ARF1-dependent manner (PubMed:28122955, PubMed:34830155, PubMed:9314526). Plays a role in sorting at early and late endosomes (PubMed:28404745). Plays a role in actin cytoskeleton organization (PubMed:28334785)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 40, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VXW6;O00040", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008289 lipid binding;GO:0120014 phospholipid transfer activity", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0044232 organelle membrane contact site;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005768 endosome", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0045053 protein retention in Golgi apparatus;GO:0007005 mitochondrion organization;GO:0009267 cellular response to starvation;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q07878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07913-1", "uniprot_id": "NSE1_YEAST", "mass": 38335.0, "length": 336, "protein_name": "Non-structural maintenance of chromosomes element 1", "gene_name": "NSE1", "organism": "Yeast", "refseq_name": "Smc5-Smc6 complex subunit NSE1", "refseq_ac": "NP_013107", "gene_names_uniprotkb": "NSE1", "gene_names_refseq": "NSE1", "protein_names_uniprotkb": "Non-structural maintenance of chromosomes element 1; 2.3.2.27; Non-SMC element 1", "protein_names_refseq": "Smc5-Smc6 complex subunit NSE1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR007W); (R-SCE-3108214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11927594;14690591;15738391;24374639;33491328;9169871", "class_list": "", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY09", "ec_number_list": "2.3.2.-;2.3.2.27", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0006301 DNA damage tolerance;GO:0140588 chromatin looping", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q07913-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07915-1", "uniprot_id": "RLP24_YEAST", "mass": 23975.0, "length": 199, "protein_name": "Ribosome biogenesis protein RLP24", "gene_name": "RLP24", "organism": "Yeast", "refseq_name": "ATPase-activating ribosome biosynthesis protein", "refseq_ac": "NP_013109", "gene_names_uniprotkb": "RLP24", "gene_names_refseq": "RLP24", "protein_names_uniprotkb": "Ribosome biogenesis protein RLP24; Ribosomal protein L24-like", "protein_names_refseq": "ATPase-activating ribosome biosynthesis protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR009W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12808088;17322287;18407956;21126336;23185031;23749301;24374639;30516470;33481703;33491328;9169871", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit (PubMed:12808088, PubMed:23185031). Ensures the docking of NOG1 to pre-60S ribosomal particles (PubMed:12808088). Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles (PubMed:23185031)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY11", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0001671 ATPase activator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0032781 positive regulation of ATP-dependent activity;GO:1902626 assembly of large subunit precursor of preribosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q07915-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07923-1", "uniprot_id": "LOT6_YEAST", "mass": 21281.0, "length": 191, "protein_name": "NAD(P)H-dependent FMN reductase LOT6", "gene_name": "LOT6", "organism": "Yeast", "refseq_name": "flavin-dependent quinone reductase", "refseq_ac": "NP_013111", "gene_names_uniprotkb": "LOT6", "gene_names_refseq": "LOT6", "protein_names_uniprotkb": "NAD(P)H-dependent FMN reductase LOT6; 1.5.1.39; Azoreductase LOT6; FMN reductase LOT6; FMN reductase [NAD(P)H]; Low temperature response protein 6", "protein_names_refseq": "flavin-dependent quinone reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR011W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11327734;14562095;14562106;15184374;17322287;22814378;24374639;9169871", "class_list": "", "function": "Has several reductase activities that are NAD(P)H-dependent and involve FMN as a cofactor, ferricyanide being the best substrate for reduction. May be involved in ferric iron assimilation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY13", "ec_number_list": "4.2.3.5;1.5.1.38;1.5.1.39", "go_molecular_function": "GO:0003955 NAD(P)H dehydrogenase (quinone) activity;GO:0010181 FMN binding;GO:0052873 FMN reductase (NADPH) activity;GO:0052874 FMN reductase (NADH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07923-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07938-1", "uniprot_id": "MTAP_YEAST", "mass": 37857.0, "length": 337, "protein_name": "S-methyl-5'-thioadenosine phosphorylase", "gene_name": "MEU1", "organism": "Yeast", "refseq_name": "S-methyl-5-thioadenosine phosphorylase", "refseq_ac": "NP_013117", "gene_names_uniprotkb": "MEU1; L1595", "gene_names_refseq": "MEU1", "protein_names_uniprotkb": "S-methyl-5'-thioadenosine phosphorylase; 2.4.2.28; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAPase; MTAP; Multicopy enhancer of UAS2", "protein_names_refseq": "S-methyl-5-thioadenosine phosphorylase", "tax_id": 559292, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); diaphyseal medullary stenosis with malignant fibrous histiocytoma (Disease Ontology:DOID:0080664); pancreatic cancer (Disease Ontology:DOID:1793); common bile duct neoplasm (Disease Ontology:DOID:4608)", "pathway": " (sce:YLR017W); (R-SCE-1237112)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14506228;14562095;14562106;16530730;17322287;18625006;19779198;24374639;33491328;8807288;9169871", "class_list": "", "function": "Catalyzes the phosphorolytic cleavage of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Seems to be implicated in the regulation of the expression of the ADH2 gene., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY19;E9P915;Q06899", "ec_number_list": "2.4.2.28", "go_molecular_function": "GO:0003729 mRNA binding;GO:0017061 S-methyl-5-thioadenosine phosphorylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006166 purine ribonucleoside salvage;GO:0019509 L-methionine salvage from methylthioadenosine;GO:0006537 glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q07938-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07950-1", "uniprot_id": "YEH2_YEAST", "mass": 62447.0, "length": 538, "protein_name": "Sterol esterase 2", "gene_name": "YEH2", "organism": "Yeast", "refseq_name": "sterol esterase", "refseq_ac": "NP_013120", "gene_names_uniprotkb": "YEH2", "gene_names_refseq": "YEH2", "protein_names_uniprotkb": "Sterol esterase 2; 3.1.1.13; Steryl ester hydrolase 2", "protein_names_refseq": "sterol esterase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR020C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;15632184;15713625;17330950;18407956;19779198;20702584;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169871", "class_list": "", "function": "Mediates the hydrolysis of steryl esters. Required for mobilization of steryl ester, thereby playing a central role in lipid metabolism., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY22", "ec_number_list": "3.1.1.13", "go_molecular_function": "GO:0004771 sterol ester esterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0016042 lipid catabolic process;GO:0016125 sterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q07950-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q07953-1", "uniprot_id": "SDO1_YEAST", "mass": 28283.0, "length": 250, "protein_name": "Ribosome maturation protein SDO1", "gene_name": "SDO1", "organism": "Yeast", "refseq_name": "guanine nucleotide exchange factor SDO1", "refseq_ac": "NP_013122", "gene_names_uniprotkb": "SDO1", "gene_names_refseq": "SDO1", "protein_names_uniprotkb": "Ribosome maturation protein SDO1", "protein_names_refseq": "guanine nucleotide exchange factor SDO1", "tax_id": 559292, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); aplastic anemia (Disease Ontology:DOID:12449)", "pathway": " (sce:YLR022C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;14690591;15701631;15701634;17353896;19713223;22814378;24374639;9169871", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with the EF-2-like GTPase RIA1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY24", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:1990932 5.8S rRNA binding;GO:0042134 rRNA primary transcript binding;GO:0070181 small ribosomal subunit rRNA binding;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042256 cytosolic ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q07953-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08001-1", "uniprot_id": "LAM6_YEAST", "mass": 78212.0, "length": 693, "protein_name": "Membrane-anchored lipid-binding protein LAM6", "gene_name": "LAM6", "organism": "Yeast", "refseq_name": "Lam6p", "refseq_ac": "NP_013173", "gene_names_uniprotkb": "LAM6; LTC1", "gene_names_refseq": "LAM6; LTC1", "protein_names_uniprotkb": "Membrane-anchored lipid-binding protein LAM6; Lipid transfer at contact site protein 1; Lipid transfer protein anchored at membrane contact sites 1", "protein_names_refseq": "Lam6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR072W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562095;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;23749301;24374639;25987606;26001273;26119743;30516470;32597660;33481703;33491328;9169871", "class_list": "", "function": "Involved in regulation of various organellar membrane contact sites (PubMed:26119743). May be involved in sterol transfer between intracellular membranes (PubMed:26001273). Selectively transports sterols between membranes in vitro. Involved in stress-dependent formation of sterol-enriched vacuolar membrane domains (PubMed:25987606)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VY73", "ec_number_list": "", "go_molecular_function": "GO:0001786 phosphatidylserine binding;GO:0032934 sterol binding;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032366 intracellular sterol transport", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q08001-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08004-1", "uniprot_id": "BUD20_YEAST", "mass": 18517.0, "length": 166, "protein_name": "Bud site selection protein 20", "gene_name": "BUD20", "organism": "Yeast", "refseq_name": "Bud20p", "refseq_ac": "NP_013175", "gene_names_uniprotkb": "BUD20", "gene_names_refseq": "BUD20", "protein_names_uniprotkb": "Bud site selection protein 20", "protein_names_refseq": "Bud20p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR074C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11452010;14562095;14562106;17322287;23045392;24374639;33481703;9169871;9171100", "class_list": "", "function": "Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:23045392). Involved in positioning the proximal bud pole signal (PubMed:11452010)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY75", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q08004-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08108-1", "uniprot_id": "PLB3_YEAST", "mass": 75077.0, "length": 686, "protein_name": "Lysophospholipase 3", "gene_name": "PLB3", "organism": "Yeast", "refseq_name": "lysophospholipase", "refseq_ac": "NP_014632", "gene_names_uniprotkb": "PLB3", "gene_names_refseq": "PLB3", "protein_names_uniprotkb": "Lysophospholipase 3; 3.1.1.5; Phospholipase B 3", "protein_names_refseq": "lysophospholipase", "tax_id": 559292, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); brain ischemia (Disease Ontology:DOID:2316); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (sce:YOL011W); (R-SCE-111995); (R-SCE-1482788); (R-SCE-1482798); (R-SCE-1482801); (R-SCE-1482839); (R-SCE-1482922); (R-SCE-1482925); (R-SCE-1483115); (R-SCE-1483152); (R-SCE-1483166); (R-SCE-2142753); (R-SCE-418592); (R-SCE-432142); (R-SCE-6811436)", "pathway_count": 15, "publication_count": 4, "publication_id_list": "10497163;15588231;24374639;9169874", "class_list": "", "function": "Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate (PubMed:10497163). Mainly responsible for the degradation of phosphatidylinositol in vivo (PubMed:15588231)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "D6W256", "ec_number_list": "2.7.11.24;3.1.1.5;3.1.1.-", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006660 phosphatidylserine catabolic process;GO:0046475 glycerophospholipid catabolic process;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08108-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08179-1", "uniprot_id": "MDM38_YEAST", "mass": 65005.0, "length": 573, "protein_name": "Mitochondrial distribution and morphology protein 38", "gene_name": "MDM38", "organism": "Yeast", "refseq_name": "ribosome-binding protein MDM38", "refseq_ac": "NP_014615", "gene_names_uniprotkb": "MDM38", "gene_names_refseq": "MDM38; MKH1", "protein_names_uniprotkb": "Mitochondrial distribution and morphology protein 38", "protein_names_refseq": "ribosome-binding protein MDM38", "tax_id": 559292, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (sce:YOL027C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11907266;14562095;14562106;14576278;15138253;19795423;19823750;20427570;21718401;24374639;9169874", "class_list": "", "function": "Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation (PubMed:11907266, PubMed:15138253). With MBA1, plays a role in ribosomal translation and protein insertion into the inner membrane (PubMed:20427570)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W238", "ec_number_list": "", "go_molecular_function": "GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0030007 intracellular potassium ion homeostasis;GO:0070131 positive regulation of mitochondrial translation;GO:1902600 proton transmembrane transport;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08179-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08193-1", "uniprot_id": "GAS5_YEAST", "mass": 51870.0, "length": 484, "protein_name": "1,3-beta-glucanosyltransferase GAS5", "gene_name": "GAS5", "organism": "Yeast", "refseq_name": "1,3-beta-glucanosyltransferase", "refseq_ac": "NP_014612", "gene_names_uniprotkb": "GAS5", "gene_names_refseq": "GAS5", "protein_names_uniprotkb": "1,3-beta-glucanosyltransferase GAS5; 2.4.1.-; Glycolipid-anchored surface protein 5", "protein_names_refseq": "1,3-beta-glucanosyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL030W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;15781460;17322287;17397106;24374639;31870255;9169874", "class_list": "", "function": "Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6W235", "ec_number_list": "", "go_molecular_function": "GO:0042124 1,3-beta-glucanosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0006074 (1->3)-beta-D-glucan metabolic process;GO:0031505 fungal-type cell wall organization;GO:0071970 fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08193-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08218-1", "uniprot_id": "LDS2_YEAST", "mass": 40878.0, "length": 356, "protein_name": "Outer spore wall protein LDS2", "gene_name": "LDS2", "organism": "Yeast", "refseq_name": "Lds2p", "refseq_ac": "NP_014595", "gene_names_uniprotkb": "LDS2", "gene_names_refseq": "LDS2", "protein_names_uniprotkb": "Outer spore wall protein LDS2; Lipid droplets in sporulation protein 2", "protein_names_refseq": "Lds2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL047C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10734188;14562095;14562106;23966878;24374639;24390141;9169874", "class_list": "", "function": "Involved in spore wall assembly., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W220", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005619 ascospore wall;GO:0005628 prospore membrane;GO:0005633 ascus lipid droplet", "go_biological_process": "GO:0030476 ascospore wall assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08218-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08220-1", "uniprot_id": "GSHB_YEAST", "mass": 55815.0, "length": 491, "protein_name": "Glutathione synthetase GSH2", "gene_name": "GSH2", "organism": "Yeast", "refseq_name": "glutathione synthase", "refseq_ac": "NP_014593", "gene_names_uniprotkb": "GSH2", "gene_names_refseq": "GSH2", "protein_names_uniprotkb": "Glutathione synthetase GSH2; 6.3.2.3; GSH synthetase; GSH-S; Glutathione synthase", "protein_names_refseq": "glutathione synthase", "tax_id": 559292, "disease": "glutathione synthetase deficiency (Disease Ontology:DOID:0080699); glutatione synthetase deficiency with 5-oxoprolinuria (Disease Ontology:DOID:0081034); congenital nonspherocytic hemolytic anemia 6 (Disease Ontology:DOID:0112252); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (sce:YOL049W); (R-SCE-174403)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12467574;14562106;17322287;18407956;19684113;19795423;19823750;24374639;33491328;9169874;9512666", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W218", "ec_number_list": "6.3.2.3", "go_molecular_function": "GO:0004363 glutathione synthase activity;GO:0043295 glutathione binding;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006750 glutathione biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08220-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08224-1", "uniprot_id": "THI20_YEAST", "mass": 61269.0, "length": 551, "protein_name": "Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20", "gene_name": "THI20", "organism": "Yeast", "refseq_name": "trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase", "refseq_ac": "NP_014586", "gene_names_uniprotkb": "THI20; O1239", "gene_names_refseq": "THI20", "protein_names_uniprotkb": "Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20; 2.7.1.49; 2.7.4.7; 3.5.99.2; HMP kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase; Hydroxymethylpyrimidine kinase; Hydroxymethylpyrimidine phosphate kinase", "protein_names_refseq": "trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL055C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10383756;14562106;15967475;17322287;21904031;24374639;8789261;9169874", "class_list": "", "function": "Trifunctional protein with both thiamine biosynthetic and degradative activity (PubMed:15967475). Within the thiamine biosynthesis pathway, catalyzes the phosphorylation of hydroxymethylpyrimidine (HMP) to hydroxymethylpyrimidine phosphate (HMP-P), as well as of HMP-P to HMP-PP (PubMed:10383756, PubMed:15967475). Also has thiaminase II activity and degrades thiamine using water as the nucleophile, resulting only in the formation of HMP (4-amino-2-methyl-5-hydroxymethylpyrimidine) and Thz (4-methyl-5-thiazole ethanol) (PubMed:15967475)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W212;Q05664;Q6B2F0", "ec_number_list": "2.7.1.49;2.7.4.7;3.5.99.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0008902 hydroxymethylpyrimidine kinase activity;GO:0008972 phosphomethylpyrimidine kinase activity;GO:0050334 thiaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0009228 thiamine biosynthetic process;GO:0009230 thiamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q08224-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08230-1", "uniprot_id": "SDHF2_YEAST", "mass": 19042.0, "length": 162, "protein_name": "Succinate dehydrogenase assembly factor 2, mitochondrial", "gene_name": "SDH5", "organism": "Yeast", "refseq_name": "succinate dehydrogenase assembly factor SDH5", "refseq_ac": "NP_014570", "gene_names_uniprotkb": "SDH5; EMI5", "gene_names_refseq": "EMI5; SDH5", "protein_names_uniprotkb": "Succinate dehydrogenase assembly factor 2, mitochondrial; SDH assembly factor 2; SDHAF2", "protein_names_refseq": "succinate dehydrogenase assembly factor SDH5", "tax_id": 559292, "disease": "paraganglioma (Disease Ontology:DOID:0050773); pheochromocytoma/paraganglioma syndrome 2 (Disease Ontology:DOID:0061217)", "pathway": " (sce:YOL071W); (R-SCE-9854311)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12432101;12586695;14562095;14562106;14576278;19628817;19837041;23062074;24374639;33491328;9169874", "class_list": "", "function": "Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDH1 of the SDH catalytic dimer. It is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDH1 in a conformation that is susceptible to autocatalytic FAD attachment (PubMed:19628817). Does not bind FAD or FADH(2) in vitro (PubMed:23062074). Involved in sporulation (PubMed:12432101). Required for the full activation of the early meiotic inducer IME1 (PubMed:12586695)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1Z6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0018293 protein-FAD linkage;GO:0034553 mitochondrial respiratory chain complex II assembly;GO:0017013 protein flavinylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08230-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08232-1", "uniprot_id": "DSC2_YEAST", "mass": 35762.0, "length": 322, "protein_name": "DSC E3 ubiquitin ligase complex subunit 2", "gene_name": "DSC2", "organism": "Yeast", "refseq_name": "Dsc2p", "refseq_ac": "NP_014568", "gene_names_uniprotkb": "DSC2", "gene_names_refseq": "DSC2", "protein_names_uniprotkb": "DSC E3 ubiquitin ligase complex subunit 2; Defective for SREBP cleavage protein 2", "protein_names_refseq": "Dsc2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL073C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16847258;17563356;18407956;24374639;25078903;29355480;33491328;9169874", "class_list": "", "function": "Component of the DSC E3 ubiquitin ligase complexes that tags proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1Z4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0044695 Dsc E3 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0140624 EGAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q08232-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08281-1", "uniprot_id": "RTC1_YEAST", "mass": 149344.0, "length": 1341, "protein_name": "Restriction of telomere capping protein 1", "gene_name": "RTC1", "organism": "Yeast", "refseq_name": "Rtc1p", "refseq_ac": "NP_014503", "gene_names_uniprotkb": "RTC1; SEA2", "gene_names_refseq": "RTC1; SEA2", "protein_names_uniprotkb": "Restriction of telomere capping protein 1; SEH-associated protein 2", "protein_names_refseq": "Rtc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL138C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14562095;14562106;15161972;15665377;16702403;17287358;17330950;17563356;18407956;18845848;19684113;19779198;19795423;19823750;20489023;21177495;21454883;23749301;24374639;32597660;33481703;33491328;8896270;9169874", "class_list": "", "function": "Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in a process influencing telomere capping., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 47, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1T1;Q92271", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005774 vacuolar membrane;GO:0061700 GATOR2 complex;GO:0035859 Seh1-associated complex;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0015031 protein transport;GO:0016239 positive regulation of macroautophagy;GO:1903432 regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q08281-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08282-1", "uniprot_id": "TYW4_YEAST", "mass": 78957.0, "length": 695, "protein_name": "tRNA wybutosine-synthesizing protein 4", "gene_name": "PPM2", "organism": "Yeast", "refseq_name": "tRNA methyltransferase PPM2", "refseq_ac": "NP_014500", "gene_names_uniprotkb": "PPM2; TYW4", "gene_names_refseq": "PPM2; TYW4", "protein_names_uniprotkb": "tRNA wybutosine-synthesizing protein 4; 2.1.1.290; 2.3.1.231; tRNA yW-synthesizing protein 4; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase", "protein_names_refseq": "tRNA methyltransferase PPM2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL141W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14576278;16642040;17150819;19287006;24374639;33481703;9169874", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the final 2 independent reactions, methylation of the alpha-carboxy group of wybutosine-72 to form wybutosine-58, and methoxycarbonylation of alpha-amino group of wybutosine-58 through the fixation of CO(2) to complete wybutosine., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S8", "ec_number_list": "2.1.1.290;2.3.1.231", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q08282-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08387-1", "uniprot_id": "DNLI4_YEAST", "mass": 108515.0, "length": 944, "protein_name": "DNA ligase 4", "gene_name": "DNL4", "organism": "Yeast", "refseq_name": "DNA ligase (ATP) DNL4", "refseq_ac": "NP_014647", "gene_names_uniprotkb": "DNL4; LIG4; UND407; UNE452", "gene_names_refseq": "DNL4; LIG4", "protein_names_uniprotkb": "DNA ligase 4; 6.5.1.1; DNA ligase II; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4", "protein_names_refseq": "DNA ligase (ATP) DNL4", "tax_id": 559292, "disease": "DNA ligase IV deficiency (Disease Ontology:DOID:0060021); prostate cancer (Disease Ontology:DOID:10283); pancreatic cancer (Disease Ontology:DOID:1793); high grade glioma (Disease Ontology:DOID:3070); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (sce:YOR005C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12235149;16388993;17567543;21177495;24374639;8896276;9092653;9169874;9271115;9670033", "class_list": "", "function": "DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W271;Q02913;Q02914", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0032807 DNA ligase IV complex;GO:0005634 nucleus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006310 DNA recombination;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q08387-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08417-1", "uniprot_id": "RSB1_YEAST", "mass": 43187.0, "length": 382, "protein_name": "Sphingoid long-chain base transporter RSB1", "gene_name": "RSB1", "organism": "Yeast", "refseq_name": "phospholipid-translocating ATPase RSB1", "refseq_ac": "NP_014692", "gene_names_uniprotkb": "RSB1; O2787", "gene_names_refseq": "RSB1", "protein_names_uniprotkb": "Sphingoid long-chain base transporter RSB1", "protein_names_refseq": "phospholipid-translocating ATPase RSB1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR049C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12034738;15342785;16407254;16847258;24146988;24374639;9169874", "class_list": "", "function": "Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W2B5", "ec_number_list": "", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0045332 phospholipid translocation;GO:1905329 sphingoid long-chain base transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q08417-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08444-1", "uniprot_id": "NOB1_YEAST", "mass": 51742.0, "length": 459, "protein_name": "20S-pre-rRNA D-site endonuclease NOB1", "gene_name": "NOB1", "organism": "Yeast", "refseq_name": "rRNA-binding endoribonuclease", "refseq_ac": "NP_014699", "gene_names_uniprotkb": "NOB1; YOR29-07", "gene_names_refseq": "NOB1; YOR29-07", "protein_names_uniprotkb": "20S-pre-rRNA D-site endonuclease NOB1; 3.1.-.-; NIN1-binding protein; Pre-rRNA-processing endonuclease NOB1", "protein_names_refseq": "rRNA-binding endoribonuclease", "tax_id": 559292, "disease": "osteosarcoma (Disease Ontology:DOID:3347); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YOR056C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12502737;12588997;12628929;14562095;14562106;15037774;15388878;19779198;22814378;24374639;32597660;33481703;33491328;34965436;9133743;9169874", "class_list": "", "function": "Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. In association with NIN1, may promote the recruitment of the proteasome to the ribosomal subunits stalled in maturation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2B9;O00021", "ec_number_list": "2.1.1.309;2.7.11.1;3.1.26.5;3.1.-.-;3.6.1.-", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0043248 proteasome assembly;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q08444-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08448-1", "uniprot_id": "LPL1_YEAST", "mass": 51106.0, "length": 450, "protein_name": "Lipid droplet phospholipase 1", "gene_name": "LPL1", "organism": "Yeast", "refseq_name": "putative hydrolase", "refseq_ac": "NP_014702", "gene_names_uniprotkb": "LPL1; YOR29-10", "gene_names_refseq": "LPL1; YOR29-10", "protein_names_uniprotkb": "Lipid droplet phospholipase 1; 3.1.-.-; 3.1.1.4", "protein_names_refseq": "putative hydrolase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR059C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10515935;14562106;19073890;24374639;25014274;9133743;9169874", "class_list": "", "function": "Phospholipase involved in maintaining the lipid droplet morphology (PubMed:25014274). Has phospholipase activity with broad substrate specificity, acting on glycerophospholipids phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidycholine (PC) and phosphatidylserine (PS), primarily at sn-2 position (PubMed:25014274). It can later remove fatty acids from the sn-1 position of the produced lysophospholipids such as lysophosphatidylethanolamine (LPE) (PubMed:25014274). Also shows activity toward phosphatidylglycerol, but, in contrast to what was observed with the other phospholipids tested, prefers the sn-1 position (PubMed:25014274)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2C2;O00022", "ec_number_list": "3.1.1.4;3.1.-.-", "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0120559 phosphatidylethanolamine lysophospholipase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0055088 lipid homeostasis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08448-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08490-1", "uniprot_id": "SGO1_YEAST", "mass": 66706.0, "length": 590, "protein_name": "Shugoshin", "gene_name": "SGO1", "organism": "Yeast", "refseq_name": "Sgo1p", "refseq_ac": "NP_014716", "gene_names_uniprotkb": "SGO1; YOR29-24", "gene_names_refseq": "SGO1; YOR29-24", "protein_names_uniprotkb": "Shugoshin", "protein_names_refseq": "Sgo1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR073W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562095;14752166;15062096;15637284;15797380;23749301;24374639;32597660;32810145;33481703;33491328;9133743;9169874", "class_list": "", "function": "Plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Probably act by protecting REC8 and RAD21 from separase degradation during anaphase. Also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2D6;O00031", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0051383 kinetochore organization;GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0045184 establishment of protein localization;GO:0007094 mitotic spindle assembly checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q08490-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08492-1", "uniprot_id": "UTP16_YEAST", "mass": 24385.0, "length": 214, "protein_name": "U3 small nucleolar RNA-associated protein 16", "gene_name": "BUD21", "organism": "Yeast", "refseq_name": "Bud21p", "refseq_ac": "NP_014721", "gene_names_uniprotkb": "BUD21; UTP16; YOR29-29", "gene_names_refseq": "BUD21; UTP16; YOR29-29", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 16; Bud site selection protein 21; U three protein 16; U3 snoRNA-associated protein 16", "protein_names_refseq": "Bud21p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR078W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11452010;12068309;14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9133743;9169874", "class_list": "", "function": "Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing (PubMed:12068309). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Has a role in bud site selection maybe via the regulation of expression of bipolar budding components (PubMed:11452010)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2E1;O00033", "ec_number_list": "", "go_molecular_function": "GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q08492-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08548-1", "uniprot_id": "ALE1_YEAST", "mass": 72228.0, "length": 619, "protein_name": "Lysophospholipid acyltransferase", "gene_name": "ALE1", "organism": "Yeast", "refseq_name": "lysophospholipid acyltransferase", "refseq_ac": "NP_014818", "gene_names_uniprotkb": "ALE1; LCA1; LPT1; O3635; SLC4", "gene_names_refseq": "ALE1; LCA1; LPT1; SLC4", "protein_names_uniprotkb": "Lysophospholipid acyltransferase; 1-acyl-sn-glycerol-3-phosphate acyltransferase; 2.3.1.23; 2.3.1.51; 2.3.1.n6; 2.3.1.n7; AGPAT; LPAAT; LPCAT; LPEAT; LPLAT; LPSAT; Lysophosphatidic acid acyltransferase; Lysophosphatidylcholine acyltransferase; Lysophosphatidylethanolamine acyltransferase; Lysophosphatidylserine acyltransferase; Sphingolipid compensation protein 4", "protein_names_refseq": "lysophospholipid acyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR175C); (R-SCE-1482788); (R-SCE-1482801); (R-SCE-1482839); (R-SCE-1482922)", "pathway_count": 5, "publication_count": 34, "publication_id_list": "10694878;11875433;14562095;15665377;16847258;17287358;17330950;17563356;17652094;17675291;17726007;17890783;17996202;18154737;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;24909858;26382650;26643989;29782033;32597660;33481703;33491328;8972579;9169874", "class_list": "", "function": "Broad specificity membrane-bound O-acyltransferase that mediates the incorporation of unsaturated acyl chains into the sn-2 position of various lysophospholipids. Preferentially acylates lysophosphocholine (LPC), but also lysophosphoethanolamine (LPE), lysophosphatidylglycerol (LPG), lysophosphatidic acid (LPA), lysophosphoethanolamine (LPE), lysophosphoinositol (LPI), and lysophosphoserine (LPS) (PubMed:17652094, PubMed:17675291, PubMed:17726007, PubMed:17890783, PubMed:17996202). Prefers an acyl residue to an alkyl residue at the sn-1 position of lysophospholipid acceptors. Accepts acyl chains in acyl-CoA from C-2 to C-20, and shows strong preference for unsaturated acyl-CoAs with 16-20 carbons (PubMed:17890783). Together with SLC1, plays a central role in phosphatidic acid (PA) biosynthesis. PA is the intermediate, from which all glycerophospholipids are synthesized (PubMed:17890783). Can also introduce an acyl chain at the sn-1 position of the lysophosphatidylcholine analog 1-hydroxy-2-hexadecyl-sn-glycero-3-phosphocholine (HHPC) (PubMed:29782033)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2N1;Q03130", "ec_number_list": "2.3.1.51;2.3.1.23;2.3.1.n7;3.1.1.3;2.3.1.n6", "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0008374 O-acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0046474 glycerophospholipid biosynthetic process;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0030258 lipid modification;GO:0090640 phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q08548-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08558-1", "uniprot_id": "DCI1_YEAST", "mass": 30058.0, "length": 271, "protein_name": "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase", "gene_name": "DCI1", "organism": "Yeast", "refseq_name": "putative dodecenoyl-CoA isomerase DCI1", "refseq_ac": "NP_014823", "gene_names_uniprotkb": "DCI1; ECI2; EHD2", "gene_names_refseq": "DCI1; ECI2", "protein_names_uniprotkb": "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase; 5.3.3.21; Peroxisomal di-isomerase DCI1", "protein_names_refseq": "putative dodecenoyl-CoA isomerase DCI1", "tax_id": 559292, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (sce:YOR180C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10381339;10455114;10639339;11302517;12429834;17322287;24374639;9169874;9774671", "class_list": "", "function": "Peroxisomal di-isomerase that is involved in fatty acid metabolism enzyme by converting 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs (PubMed:10381339, PubMed:10455114). Required for ECI1 to be located to the peroxisome (PubMed:10381339, PubMed:11302517)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2N6", "ec_number_list": "5.3.3.21", "go_molecular_function": "GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity;GO:0051750 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q08558-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08562-1", "uniprot_id": "ULS1_YEAST", "mass": 184406.0, "length": 1619, "protein_name": "ATP-dependent chromatin remodeler/ubiquitin-protein ligase E3 ULS1", "gene_name": "ULS1", "organism": "Yeast", "refseq_name": "translocase ULS1", "refseq_ac": "NP_014834", "gene_names_uniprotkb": "ULS1; DIS1; RIS1; TID4", "gene_names_refseq": "DIS1; RIS1; TID4; ULS1", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler/ubiquitin-protein ligase E3 ULS1; 2.3.2.27; 3.6.4.-; DNA translocase ULS1; Role in silencing protein 1; Ubiquitin ligase for SUMO conjugates protein 1", "protein_names_refseq": "translocase ULS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR191W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562095;17728242;18407956;18603780;19779198;19795423;19823750;21126336;23749301;24374639;28552615;32597660;33481703;33491328;9169874;9271422", "class_list": "", "function": "ATP-dependent chromatin remodeller involved in mating type switching and silencing interference through its interaction with the silencing regulator SIR4 (PubMed:9271422). Cooperates with UBC4 and UBC5 to mediate ubiquitination of SUMO conjugates (PubMed:17728242). Protects against genotoxic stress; possibly by acting as a DNA translocase that displaces sumoylated TOP2 from DNA (PubMed:28552615)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2P7", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0061630 ubiquitin protein ligase activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000776 kinetochore", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0000724 double-strand break repair via homologous recombination;GO:0007533 mating type switching", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q08562-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08581-1", "uniprot_id": "SLK19_YEAST", "mass": 95380.0, "length": 821, "protein_name": "Kinetochore protein SLK19", "gene_name": "SLK19", "organism": "Yeast", "refseq_name": "Slk19p", "refseq_ac": "NP_014838", "gene_names_uniprotkb": "SLK19", "gene_names_refseq": "SLK19", "protein_names_uniprotkb": "Kinetochore protein SLK19; Synthetic lethal KAR3 protein 19", "protein_names_refseq": "Slk19p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR195W)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10427094;10835382;11050386;11533655;11832211;12354097;12737807;14562095;14562106;14574415;15282802;17287358;17563356;18407956;19779198;19795423;19823750;21126336;21177495;22218487;22814378;23749301;24374639;32597660;33481703;33491328;9169874", "class_list": "", "function": "Has a role in spindle assembly and stability. Required to ensure a timely exit form mitosis. Essential to maintain pre-anaphase spindle polarity. Associates to the plus ends of the microtubules at the kinetochore and spindle midzone. A component of the FEAR (CDC14 Early Anaphase Release) network which promotes CDC14 release from the nucleolus during early anaphase. Required for proper chromosome segregation during meiosis I where it prevents premature sister chromatid separation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Q4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005819 spindle;GO:0005874 microtubule;GO:0051233 spindle midzone;GO:0000776 kinetochore;GO:0005816 spindle pole body", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0031536 positive regulation of exit from mitosis;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q08581-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08601-1", "uniprot_id": "MCA1_YEAST", "mass": 47982.0, "length": 432, "protein_name": "Metacaspase-1", "gene_name": "MCA1", "organism": "Yeast", "refseq_name": "Ca(2+)-dependent cysteine protease MCA1", "refseq_ac": "NP_014840", "gene_names_uniprotkb": "MCA1; YCA1", "gene_names_refseq": "MCA1; YCA1", "protein_names_uniprotkb": "Metacaspase-1; 3.4.22.-", "protein_names_refseq": "Ca(2+)-dependent cysteine protease MCA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR197W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "11983181;12748633;12775844;14562095;14562106;14718573;14970189;15381687;15489197;15668299;15939758;16079294;16170310;16301538;17322287;19174511;20624963;22761449;24374639;30675380;33481703;33491328;9169874", "class_list": "", "function": "Cysteine protease that cleaves specifically after arginine or lysine residues (PubMed:22761449). Mediates cell death (apoptosis) triggered by oxygen stress, salt stress or chronological aging. Regulated cell death can prevent a release of toxic cellular components, thus avoiding necrotic collapse of the colony, and can also provide nutrients for healthy cells. Therefore, regulated cell death in yeast colonies can be as important for their development as are apoptosis and related processes that occur within metazoa. Promotes the removal of insoluble protein aggregates during normal growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Q6", "ec_number_list": "", "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q08601-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08641-1", "uniprot_id": "AB140_YEAST", "mass": 71486.0, "length": 628, "protein_name": "tRNA(Thr) (cytosine(32)-N(3))-methyltransferase", "gene_name": "ABP140", "organism": "Yeast", "refseq_name": "tRNA(Thr) (cytosine(32)-N(3))-methyltransferase", "refseq_ac": "NP_014882", "gene_names_uniprotkb": "ABP140; TRM140; YOR240W", "gene_names_refseq": "ABP140; TRM140; YOR240W", "protein_names_uniprotkb": "tRNA(Thr) (cytosine(32)-N(3))-methyltransferase; 2.1.1.268; Actin-binding protein of 140 kDa; tRNA methyltransferase of 140 kDa", "protein_names_refseq": "tRNA(Thr) (cytosine(32)-N(3))-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR239W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;21518804;21518805;21792172;22218487;23749301;24374639;24909858;28003514;32597660;33481703;33491328;8972580;9169874;9467951", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr) and tRNA(Ser) (PubMed:21518804, PubMed:21518805, PubMed:28003514). N(3)-methylcytidine methylation of tRNA(Thr) requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:28003514). N(3)-methylcytidine methylation of tRNA(Ser) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by MOD5 as prerequisite (PubMed:28003514). Methylation of tRNA(Ser) is also stimulated by SES1 (PubMed:28003514). Binds F-actin and shows weak F-actin cross-linking activity (PubMed:9467951)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2U2;Q08644", "ec_number_list": "2.1.1.268", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0032432 actin filament bundle;GO:0043332 mating projection tip", "go_biological_process": "GO:0030488 tRNA methylation;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q08641-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08645-1", "uniprot_id": "FOLE_YEAST", "mass": 62151.0, "length": 548, "protein_name": "Folylpolyglutamate synthase", "gene_name": "MET7", "organism": "Yeast", "refseq_name": "tetrahydrofolate synthase", "refseq_ac": "NP_014884", "gene_names_uniprotkb": "MET7; MET23; O5248", "gene_names_refseq": "MET23; MET7", "protein_names_uniprotkb": "Folylpolyglutamate synthase; 6.3.2.17; FPGS; Folylpoly-gamma-glutamate synthetase; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase", "protein_names_refseq": "tetrahydrofolate synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR241W); (R-SCE-196757)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10775416;10799479;14562106;15161972;17322287;19795423;19823750;24374639;33481703;33491328;8972580;9169874", "class_list": "", "function": "Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Required for methionine synthesis and maintenance of intact mitochondrial DNA. Involved in telomere maintenance., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2U3", "ec_number_list": "6.3.2.17", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004326 tetrahydrofolylpolyglutamate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q08645-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08647-1", "uniprot_id": "PUS7_YEAST", "mass": 77002.0, "length": 676, "protein_name": "Multisubstrate pseudouridine synthase 7", "gene_name": "PUS7", "organism": "Yeast", "refseq_name": "pseudouridine synthase PUS7", "refseq_ac": "NP_014886", "gene_names_uniprotkb": "PUS7; O5254", "gene_names_refseq": "PUS7", "protein_names_uniprotkb": "Multisubstrate pseudouridine synthase 7; 5.4.99.-; 5.4.99.27; RNA pseudouridylate synthase 7; RNA-uridine isomerase 7; tRNA pseudouridine(13) synthase", "protein_names_refseq": "pseudouridine synthase PUS7", "tax_id": 559292, "disease": "intellectual developmental disorder with abnormal behavior, microcephaly, and short stature (Disease Ontology:DOID:0081265); intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (sce:YOR243C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12426583;12682021;14561887;14562095;14562106;15611063;18332121;18435545;19114708;21131909;22814378;24374639;25219674;33481703;33491328;35058356;8972580;9169874", "class_list": "", "function": "Catalyzes pseudouridylation at position 35 in U2 snRNA stem-loop II region which induces particular conformation of the mRNA-U2 snRNA duplex and places the nucleophile in an accessible position for the first step of splicing (PubMed:12426583, PubMed:12682021, PubMed:15611063, PubMed:18435545, PubMed:19114708, PubMed:25219674). Also catalyzes pseudouridylation at position 56 in U2 snRNA (PubMed:21131909). Also catalyzes pseudouridylation at position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr) (PubMed:14561887, PubMed:18332121, PubMed:25219674, PubMed:35058356). Pseudouridine residues in tRNAs may stabilize the local RNA conformation, favor interactions with protein partners and play an important role in the stabilization of the codon-anticodon interaction with mRNA (PubMed:14561887). Also catalyzes pseudouridylation of mRNAs in response to heat shock: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAR-3' (PubMed:25219674, PubMed:35058356)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2U5", "ec_number_list": "5.4.99.-;5.4.99.25;5.4.99.27", "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0106032 snRNA pseudouridine synthase activity;GO:0160150 tRNA pseudouridine(13) synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031429 box H/ACA snoRNP complex", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0006400 tRNA modification;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q08647-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08650-1", "uniprot_id": "DGAT2_YEAST", "mass": 47711.0, "length": 418, "protein_name": "Diacylglycerol O-acyltransferase 1", "gene_name": "DGA1", "organism": "Yeast", "refseq_name": "diacylglycerol O-acyltransferase", "refseq_ac": "NP_014888", "gene_names_uniprotkb": "DGA1", "gene_names_refseq": "DGA1", "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 1; 2.3.1.20; 2.3.1.22; Acyl-CoA-dependent diacylglycerol O-acyltransferase; Acyl-CoA:monoacylglycerol acyltransferase; DGAT; MGAT; TAG synthase; Triacylglycerol synthase", "protein_names_refseq": "diacylglycerol O-acyltransferase", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); dry eye syndrome (Disease Ontology:DOID:10140); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (sce:YOR245C); (R-SCE-1482883); (R-SCE-2142753); (R-SCE-75109); (R-SCE-9640463)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "11741946;11751830;11751875;14562095;14562106;14640980;15155725;17330950;18407956;20225889;20554061;21321129;21820081;22738231;24374639;24868093;27620384;32349126;32597660;33481703;33491328;9169874", "class_list": "", "function": "Catalyzes the terminal and only committed step in triacylglycerol (TAG) synthesis by using diacylglycerol (DAG) and fatty acyl-CoA as substrates. Required for storage lipid synthesis. Major DAG esterifying enzyme in stationary phase when TAG production is particularly active. Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains, and in ergosterol biosynthesis (PubMed:11741946, PubMed:11751830, PubMed:11751875, PubMed:14640980, PubMed:15155725, PubMed:21321129, PubMed:32349126). Also has monoacylglycerol acyltransferase (MGAT) activity, catalyzing the acyl-CoA-dependent esterification of monoacylglycerol to diacylglycerol (PubMed:20554061). Can also utilize ceramide instead of DAG, acylating the ceramides by attaching a fatty acid to the hydroxy group on the first carbon atom of the long-chain base to produce 1-O-acylceramides (PubMed:22738231)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W2U7", "ec_number_list": "2.3.1.20;2.3.1.22", "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006672 ceramide metabolic process;GO:0019915 lipid storage;GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process;GO:0035356 intracellular triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q08650-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08651-1", "uniprot_id": "ENV9_YEAST", "mass": 37485.0, "length": 330, "protein_name": "Probable oxidoreductase ENV9", "gene_name": "ENV9", "organism": "Yeast", "refseq_name": "Env9p", "refseq_ac": "NP_014889", "gene_names_uniprotkb": "ENV9", "gene_names_refseq": "ENV9", "protein_names_uniprotkb": "Probable oxidoreductase ENV9; 1.1.1.-; Late endosome and vacuole interface protein 9", "protein_names_refseq": "Env9p", "tax_id": 559292, "disease": "autosomal recessive spinocerebellar ataxia 12 (Disease Ontology:DOID:0080060); developmental and epileptic encephalopathy 28 (Disease Ontology:DOID:0080452); Leber congenital amaurosis 13 (Disease Ontology:DOID:0110330); Leber congenital amaurosis (Disease Ontology:DOID:14791); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (sce:YOR246C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;14671320;19756047;21912603;24374639;9153759;9169874", "class_list": "", "function": "Probable dehydrogenase required for replication of Brome mosaic virus. Involved in vacuolar processing and morphology., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2U8", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0005773 vacuole", "go_biological_process": "GO:0034389 lipid droplet organization;GO:0007033 vacuole organization;GO:0006624 vacuolar protein processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q08651-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08689-1", "uniprot_id": "NAT5_YEAST", "mass": 19727.0, "length": 176, "protein_name": "N-alpha-acetyltransferase NAT5", "gene_name": "NAT5", "organism": "Yeast", "refseq_name": "peptide alpha-N-acetyltransferase subunit NAT5", "refseq_ac": "NP_014896", "gene_names_uniprotkb": "NAT5", "gene_names_refseq": "ARD2; NAA50; NAT5; ROG2", "protein_names_uniprotkb": "N-alpha-acetyltransferase NAT5; 2.3.1.258; NatA complex subunit NAT5", "protein_names_refseq": "peptide alpha-N-acetyltransferase subunit NAT5", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR253W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14517307;14562095;14562106;17322287;24374639;25886145;9169874", "class_list": "", "function": "N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:25886145). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides (PubMed:25886145). Non-essential component of the NatA N-terminal acetyltransferase (PubMed:14517307)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2V4", "ec_number_list": "2.3.1.256;2.3.1.258", "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0031415 NatA complex", "go_biological_process": "GO:0007064 mitotic sister chromatid cohesion;GO:0006474 N-terminal protein amino acid acetylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08689-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08702-1", "uniprot_id": "APTX_YEAST", "mass": 25757.0, "length": 217, "protein_name": "Aprataxin-like protein", "gene_name": "HNT3", "organism": "Yeast", "refseq_name": "DNA 5'-adenosine monophosphate hydrolase", "refseq_ac": "NP_014901", "gene_names_uniprotkb": "HNT3", "gene_names_refseq": "HNT3", "protein_names_uniprotkb": "Aprataxin-like protein; 3.6.1.71; 3.6.1.72; Hit family protein 3", "protein_names_refseq": "DNA 5'-adenosine monophosphate hydrolase", "tax_id": 559292, "disease": "early-onset ataxia with oculomotor apraxia and hypoalbuminemia (Disease Ontology:DOID:0050754); olivopontocerebellar atrophy (Disease Ontology:DOID:14784)", "pathway": " (sce:YOR258W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;16547001;16964241;24362567;24374639;3526331;9153759;9169874", "class_list": "", "function": "DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:24362567). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2V9;Q05189", "ec_number_list": "3.6.1.71;3.6.1.72", "go_molecular_function": "GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity;GO:0003697 single-stranded DNA binding;GO:0030983 mismatched DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0000012 single strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q08702-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08747-1", "uniprot_id": "UAF30_YEAST", "mass": 25967.0, "length": 228, "protein_name": "Upstream activation factor subunit UAF30", "gene_name": "UAF30", "organism": "Yeast", "refseq_name": "Uaf30p", "refseq_ac": "NP_014938", "gene_names_uniprotkb": "UAF30", "gene_names_refseq": "UAF30", "protein_names_uniprotkb": "Upstream activation factor subunit UAF30; Upstream activation factor 30 KDa subunit; p30", "protein_names_refseq": "Uaf30p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR295W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11500378;14562095;14562106;17330950;17563356;18407956;19684113;20702584;23749301;24374639;32597660;33481703;33491328;33502312;9169874", "class_list": "", "function": "Nonessential component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level. UAF30 seems to play a role in silencing transcription by RNA polymerase II., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Z4", "ec_number_list": "", "go_molecular_function": "GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000500 RNA polymerase I upstream activating factor complex", "go_biological_process": "GO:0006325 chromatin organization;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q08747-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08749-1", "uniprot_id": "TIM18_YEAST", "mass": 21972.0, "length": 192, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM18", "gene_name": "TIM18", "organism": "Yeast", "refseq_name": "Tim18p", "refseq_ac": "NP_014940", "gene_names_uniprotkb": "TIM18", "gene_names_refseq": "TIM18", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM18", "protein_names_refseq": "Tim18p", "tax_id": 559292, "disease": "paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 1 (Disease Ontology:DOID:0061216); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533)", "pathway": " (sce:YOR297C); (R-SCE-71403)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10637294;10648604;12637749;14504216;14562095;14562106;21126336;24374639;9153758;9169874", "class_list": "", "function": "Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. Its role in the complex is unclear but it may be involved in the assembly and stabilization of the TIM22 complex., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Z6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006970 response to osmotic stress;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0006915 apoptotic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q08749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08760-1", "uniprot_id": "RAX1_YEAST", "mass": 50161.0, "length": 435, "protein_name": "Bud site selection protein RAX1", "gene_name": "RAX1", "organism": "Yeast", "refseq_name": "Rax1p", "refseq_ac": "NP_014945", "gene_names_uniprotkb": "RAX1", "gene_names_refseq": "RAX1", "protein_names_uniprotkb": "Bud site selection protein RAX1; Revert to axial protein 1", "protein_names_refseq": "Rax1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR301W); (R-SCE-983231)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14980713;15356260;16847258;17287358;18407956;19779198;20678480;21126336;23749301;24374639;32152126;32597660;33481703;33491328;9153758;9169874", "class_list": "", "function": "Required for the establishment of the bipolar budding pattern (PubMed:14980713). Involved in selecting bud sites at both the distal and proximal poles of daughter cells as well as near previously used division sites on mother cells (PubMed:14980713). The RAX1-RAX2 complex performs the asymmetric localization of the two cortical landmarks, BUD8 and BUD9, at the distal and proximal poles, respectively (PubMed:14980713, PubMed:20678480, PubMed:32152126)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W300", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole;GO:0005621 cellular bud scar;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0007120 axial cellular bud site selection;GO:0007121 bipolar cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q08760-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08773-1", "uniprot_id": "ISW2_YEAST", "mass": 130327.0, "length": 1120, "protein_name": "ISWI chromatin-remodeling complex ATPase ISW2", "gene_name": "ISW2", "organism": "Yeast", "refseq_name": "DNA translocase", "refseq_ac": "NP_014948", "gene_names_uniprotkb": "ISW2", "gene_names_refseq": "ISW2", "protein_names_uniprotkb": "ISWI chromatin-remodeling complex ATPase ISW2; 3.6.4.-; Imitation switch protein 2", "protein_names_refseq": "DNA translocase", "tax_id": 559292, "disease": "central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (sce:YOR304W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10090725;11081629;11238381;11238944;11489850;11533234;14562095;14562106;14673157;15024052;17330950;17563356;18407956;19779198;19795423;19823750;20190278;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169874", "class_list": "", "function": "Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing. It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W303", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0008623 CHRAC;GO:0000781 chromosome, telomeric region;GO:0005880 nuclear microtubule", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q08773-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08826-1", "uniprot_id": "SNX3_YEAST", "mass": 18770.0, "length": 162, "protein_name": "Sorting nexin-3", "gene_name": "SNX3", "organism": "Yeast", "refseq_name": "Snx3p", "refseq_ac": "NP_015002", "gene_names_uniprotkb": "SNX3; GRD19", "gene_names_refseq": "GRD19; SNX3", "protein_names_uniprotkb": "Sorting nexin-3; Golgi retention deficient protein 19", "protein_names_refseq": "Snx3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR357C); (R-SCE-3238698)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14514667;15263065;17287358;18407956;24374639;28404745;32597660;33481703;33491328;9169874;9456318", "class_list": "", "function": "Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3))., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W352", "ec_number_list": "", "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0030904 retromer complex", "go_biological_process": "GO:0015031 protein transport;GO:0008104 intracellular protein localization;GO:0032456 endocytic recycling;GO:0034499 late endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08826-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08831-1", "uniprot_id": "VTS1_YEAST", "mass": 57557.0, "length": 523, "protein_name": "RNA-binding protein VTS1", "gene_name": "VTS1", "organism": "Yeast", "refseq_name": "Vts1p", "refseq_ac": "NP_015004", "gene_names_uniprotkb": "VTS1", "gene_names_refseq": "VTS1", "protein_names_uniprotkb": "RNA-binding protein VTS1; VTI1-2 suppressor protein 1", "protein_names_refseq": "Vts1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR359W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11445562;12858164;14562095;14562106;18407956;19684113;19779198;19795423;19823750;21177495;22218487;23273919;23749301;24374639;32597660;33229814;33481703;33491328;9169874", "class_list": "", "function": "RNA-binding protein involved in post-transcriptional regulation through transcript degradation of SRE (SMG-recognition elements) bearing mRNAs., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6W354", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000166 nucleotide binding;GO:0070336 flap-structured DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0015031 protein transport;GO:0051054 positive regulation of DNA metabolic process;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q08831-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08886-1", "uniprot_id": "GPB1_YEAST", "mass": 100940.0, "length": 897, "protein_name": "Guanine nucleotide-binding protein subunit beta 1", "gene_name": "GPB1", "organism": "Yeast", "refseq_name": "Gpb1p", "refseq_ac": "NP_015016", "gene_names_uniprotkb": "GPB1; KRH2", "gene_names_refseq": "GPB1; KRH2", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta 1; Gbeta mimic kelch protein 1", "protein_names_refseq": "Gpb1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR371C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12150916;12538771;14562095;14562106;16278446;17330950;17563356;18407956;19779198;19795423;19823750;21126336;23749301;24374639;32597660;33481703;33491328;9169874", "class_list": "", "function": "Beta subunit of a guanine nucleotide-binding protein (G proteins). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W364", "ec_number_list": "", "go_molecular_function": "GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0046580 negative regulation of Ras protein signal transduction;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0042326 negative regulation of phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q08886-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08887-1", "uniprot_id": "NDD1_YEAST", "mass": 60523.0, "length": 554, "protein_name": "Nuclear division defective protein 1", "gene_name": "NDD1", "organism": "Yeast", "refseq_name": "Ndd1p", "refseq_ac": "NP_015017", "gene_names_uniprotkb": "NDD1", "gene_names_refseq": "NDD1", "protein_names_uniprotkb": "Nuclear division defective protein 1", "protein_names_refseq": "Ndd1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR372C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10207056;10894549;11572776;12183363;12865300;14521842;14562095;14562106;15949038;16912276;17122856;18407956;19779198;20190278;22218487;22966207;23749301;24374639;32597660;33229814;33481703;33491328;34088668;9169874", "class_list": "", "function": "Transcription activator involved in G2/M transcription through its association with FKH2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6W365", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q08887-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08905-1", "uniprot_id": "FRE3_YEAST", "mass": 80589.0, "length": 711, "protein_name": "Ferric reductase transmembrane component 3", "gene_name": "FRE3", "organism": "Yeast", "refseq_name": "ferric-chelate reductase", "refseq_ac": "NP_015026", "gene_names_uniprotkb": "FRE3; O6754", "gene_names_refseq": "FRE3", "protein_names_uniprotkb": "Ferric reductase transmembrane component 3; 1.16.1.9; Ferric-chelate reductase 3", "protein_names_refseq": "ferric-chelate reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR381W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10341420;11120744;16847258;24374639;9169874;9726978", "class_list": "", "function": "Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W373", "ec_number_list": "1.16.1.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0052851 ferric-chelate reductase (NADPH) activity;GO:0000293 ferric-chelate reductase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0015677 copper ion import;GO:0006826 iron ion transport;GO:0015891 siderophore transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q08905-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08923-1", "uniprot_id": "CTI6_YEAST", "mass": 57053.0, "length": 506, "protein_name": "Histone deacetylase complex subunit CTI6", "gene_name": "CTI6", "organism": "Yeast", "refseq_name": "Cti6p", "refseq_ac": "NP_015144", "gene_names_uniprotkb": "CTI6; RXT1", "gene_names_refseq": "CTI6; RXT1", "protein_names_uniprotkb": "Histone deacetylase complex subunit CTI6; CYC8-TUP1-interacting protein 6; Transcriptional regulatory protein CTI6", "protein_names_refseq": "Cti6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL181W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "11805826;12086626;14562095;14562106;15133041;16286008;16314178;16437160;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;23749301;24374639;30516470;32597660;33481703;33491328;9169875", "class_list": "", "function": "Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor. Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3I7;Q6B1X3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0070210 Rpd3L-Expanded complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q08923-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08924-1", "uniprot_id": "WDR6_YEAST", "mass": 114461.0, "length": 1013, "protein_name": "tRNA (34-2'-O)-methyltransferase regulator RTT10", "gene_name": "RTT10", "organism": "Yeast", "refseq_name": "tRNA (34-2'-O)-methyltransferase regulator RTT10", "refseq_ac": "NP_015142", "gene_names_uniprotkb": "RTT10; ERE2; TRM734", "gene_names_refseq": "ERE2; RTT10; TRM734", "protein_names_uniprotkb": "tRNA (34-2'-O)-methyltransferase regulator RTT10; Endosomal recycling protein 2; Regulator of Ty1 transposition protein 10; tRNA (guanosine(34)-2'-O)-methyltransferase non-catalytic subunit TRM734", "protein_names_refseq": "tRNA (34-2'-O)-methyltransferase regulator RTT10", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL183C); (R-SCE-9013420); (R-SCE-9013424); (R-SCE-9696273)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "14562095;14562106;18202368;18407956;21126336;21880895;22912484;24374639;26310293;31586407;35559166;9169875", "class_list": "", "function": "Together with methyltransferase TRM7, methylates the 2'-O-ribose of nucleotides at position 34 of the anticodon loop of substrate tRNAs (PubMed:22912484, PubMed:31586407). Required for the correct positioning of the substrate tRNA for methylation (PubMed:31586407). Also plays a role in the regulation of the retromer complex and is required for the recycling of plasma membrane proteins like CAN1 and MUP1 from endosomes (PubMed:21880895). Involved in regulation of Ty1 transposition (PubMed:18202368)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W3I6", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0030488 tRNA methylation;GO:0032456 endocytic recycling;GO:0002130 wobble position ribose methylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q08924-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08931-1", "uniprot_id": "PRM3_YEAST", "mass": 14428.0, "length": 133, "protein_name": "Pheromone-regulated membrane protein 3", "gene_name": "PRM3", "organism": "Yeast", "refseq_name": "pheromone-regulated protein PRM3", "refseq_ac": "NP_015132", "gene_names_uniprotkb": "PRM3", "gene_names_refseq": "PRM3", "protein_names_uniprotkb": "Pheromone-regulated membrane protein 3", "protein_names_refseq": "pheromone-regulated protein PRM3", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL192C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11062271;12514182;17322287;17996101;18660802;19297527;19369416;19570912;20584076;24374639;33481703;33491328;9169875", "class_list": "", "function": "Required for the fusion of nuclear envelopes during mating, ensuring proper karyogamy. Plays a role in the initiation of outer nuclear envelope fusion., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3H6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0034399 nuclear periphery;GO:0005640 nuclear outer membrane;GO:0005816 spindle pole body", "go_biological_process": "GO:0000742 karyogamy involved in conjugation with cellular fusion;GO:0048288 nuclear membrane fusion involved in karyogamy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q08931-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08959-1", "uniprot_id": "PGC1_YEAST", "mass": 37070.0, "length": 321, "protein_name": "Phosphatidylglycerol phospholipase C", "gene_name": "PGC1", "organism": "Yeast", "refseq_name": "phosphatidylglycerol phospholipase", "refseq_ac": "NP_015118", "gene_names_uniprotkb": "PGC1", "gene_names_refseq": "PGC1", "protein_names_uniprotkb": "Phosphatidylglycerol phospholipase C; 3.1.4.-", "protein_names_refseq": "phosphatidylglycerol phospholipase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL206C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12514182;14562106;14576278;16141200;16172116;18434318;22814378;24374639;24868093;9169875", "class_list": "", "function": "Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C-type degradation mechanism., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3G4", "ec_number_list": "3.1.4.-", "go_molecular_function": "GO:0034479 phosphatidylglycerol phospholipase C activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process;GO:0034478 phosphatidylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q08959-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08960-1", "uniprot_id": "TYW1_YEAST", "mass": 89805.0, "length": 810, "protein_name": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase", "gene_name": "TYW1", "organism": "Yeast", "refseq_name": "putative tRNA 4-demethylwyosine synthase", "refseq_ac": "NP_015117", "gene_names_uniprotkb": "TYW1", "gene_names_refseq": "TYW1", "protein_names_uniprotkb": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; 4.1.3.44; tRNA wybutosine-synthesizing protein 1", "protein_names_refseq": "putative tRNA 4-demethylwyosine synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL207W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12872131;14562095;14562106;16162496;16642040;18407956;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "Component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3G3", "ec_number_list": "4.1.3.44", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0010181 FMN binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0102521 tRNA-4-demethylwyosine synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q08960-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08967-1", "uniprot_id": "FLC1_YEAST", "mass": 89291.0, "length": 793, "protein_name": "Flavin carrier protein 1", "gene_name": "FLC1", "organism": "Yeast", "refseq_name": "flavin adenine dinucleotide transporter", "refseq_ac": "NP_015103", "gene_names_uniprotkb": "FLC1; BOP1; HUF1", "gene_names_refseq": "FLC1", "protein_names_uniprotkb": "Flavin carrier protein 1; Bypass of PAM1 protein 1; FAD transporter 1; Heme utilization factor 1; TRP-like ion channel protein FLC1", "protein_names_refseq": "flavin adenine dinucleotide transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL221W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "15665377;16717099;16847258;17330950;18407956;19684113;19779198;19795423;19823750;20702584;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W3E9", "ec_number_list": "", "go_molecular_function": "GO:0015230 FAD transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0000324 fungal-type vacuole;GO:0005935 cellular bud neck", "go_biological_process": "GO:0055085 transmembrane transport;GO:0030148 sphingolipid biosynthetic process;GO:0006457 protein folding;GO:0015883 FAD transport;GO:0009272 fungal-type cell wall biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q08967-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08972-1", "uniprot_id": "NEW1_YEAST", "mass": 134331.0, "length": 1196, "protein_name": "[NU+] prion formation protein 1", "gene_name": "NEW1", "organism": "Yeast", "refseq_name": "New1p", "refseq_ac": "NP_015098", "gene_names_uniprotkb": "NEW1; P1445", "gene_names_refseq": "NEW1", "protein_names_uniprotkb": "[NU+] prion formation protein 1", "protein_names_refseq": "New1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL226W); (R-SCE-382556)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10660050;11511345;11511346;11875433;14562095;14562106;15665377;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;32597660;33229814;33481703;33491328;9020838;9169875", "class_list": "", "function": "May be involved in the mRNA export process (By similarity). Forms the [NU+] prion and induces [PSI+] prion formation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W3E4;Q05402;Q7LHP2", "ec_number_list": "", "go_molecular_function": "GO:0008079 translation termination factor activity;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0051028 mRNA transport;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q08972-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08984-1", "uniprot_id": "PBI1_YEAST", "mass": 59389.0, "length": 517, "protein_name": "PSTB2-interacting protein 1", "gene_name": "PBI1", "organism": "Yeast", "refseq_name": "Pbi1p", "refseq_ac": "NP_015051", "gene_names_uniprotkb": "PBI1", "gene_names_refseq": "PBI1", "protein_names_uniprotkb": "PSTB2-interacting protein 1", "protein_names_refseq": "Pbi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL272C)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "24366873;24374639;33491328;9169875", "class_list": "", "function": "Phosphatidic acid-binding protein involved in interorganelle phosphatidylserine (PtdSer) transport (PubMed:24366873). Linkks a PtdSer donor membrane (via binding of SCS2 and phosphatidic acid present in the donor membrane) with an acceptor membrane (via its interaction with PDR17), forming a zone of apposition that facilitates PtdSer transfer (PubMed:24366873)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W398", "ec_number_list": "", "go_molecular_function": "GO:0008080 N-acetyltransferase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08985-1", "uniprot_id": "SAM4_YEAST", "mass": 36669.0, "length": 325, "protein_name": "Homocysteine S-methyltransferase 2", "gene_name": "SAM4", "organism": "Yeast", "refseq_name": "S-adenosylmethionine-homocysteine S-methyltransferase SAM4", "refseq_ac": "NP_015050", "gene_names_uniprotkb": "SAM4", "gene_names_refseq": "SAM4", "protein_names_uniprotkb": "Homocysteine S-methyltransferase 2; 2.1.1.10; S-adenosylmethionine metabolism protein 4; S-methylmethionine:homocysteine methyltransferase 2; SMM:Hcy S-methyltransferase 2", "protein_names_refseq": "S-adenosylmethionine-homocysteine S-methyltransferase SAM4", "tax_id": 559292, "disease": "congenital heart disease (Disease Ontology:DOID:1682); cerebral infarction (Disease Ontology:DOID:3526); hepatocellular carcinoma (Disease Ontology:DOID:684); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (sce:YPL273W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11013242;14562095;14562106;18407956;24374639;33481703;33491328;9169875", "class_list": "", "function": "Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Also converts S-methylmethionine (SMM) to methionine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W397", "ec_number_list": "2.1.1.10", "go_molecular_function": "GO:0046872 metal ion binding;GO:0061627 S-methylmethionine-homocysteine S-methyltransferase activity;GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation;GO:0050667 homocysteine metabolic process;GO:0033353 S-adenosylmethionine cycle;GO:0019284 L-methionine salvage from S-adenosylmethionine", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q08985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08986-1", "uniprot_id": "SAM3_YEAST", "mass": 64354.0, "length": 587, "protein_name": "S-adenosylmethionine permease SAM3", "gene_name": "SAM3", "organism": "Yeast", "refseq_name": "bifunctional polyamine/amino acid permease SAM3", "refseq_ac": "NP_015049", "gene_names_uniprotkb": "SAM3", "gene_names_refseq": "SAM3", "protein_names_uniprotkb": "S-adenosylmethionine permease SAM3; S-adenosylmethionine metabolism protein 3", "protein_names_refseq": "bifunctional polyamine/amino acid permease SAM3", "tax_id": 559292, "disease": "retinitis pigmentosa 68 (Disease Ontology:DOID:0110374)", "pathway": " (sce:YPL274W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10497160;14562095;14562106;15665377;16847258;19684113;19779198;21177495;22218487;23749301;24374639;32597660;33481703;33491328;9169875", "class_list": "", "function": "High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W396;Q7LGU1", "ec_number_list": "", "go_molecular_function": "GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015489 putrescine transmembrane transporter activity;GO:0015606 spermidine transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015805 S-adenosyl-L-methionine transport;GO:0003333 amino acid transmembrane transport;GO:0015847 putrescine transport;GO:0015848 spermidine transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q08986-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q08992-1", "uniprot_id": "HSP32_YEAST", "mass": 25940.0, "length": 237, "protein_name": "Probable glutathione-independent glyoxalase HSP32", "gene_name": "HSP32", "organism": "Yeast", "refseq_name": "glutathione-independent methylglyoxalase family protein", "refseq_ac": "NP_015043", "gene_names_uniprotkb": "HSP32", "gene_names_refseq": "HSP32", "protein_names_uniprotkb": "Probable glutathione-independent glyoxalase HSP32; 4.2.1.130; Glyoxalase 3 homolog 2; Heat shock protein 32", "protein_names_refseq": "glutathione-independent methylglyoxalase family protein", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YPL280W)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14745011;24374639;24706893;9169875", "class_list": "", "function": "Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W392", "ec_number_list": "4.2.1.130", "go_molecular_function": "GO:0044183 protein folding chaperone;GO:0019172 glyoxalase III activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0006457 protein folding;GO:0031669 cellular response to nutrient levels;GO:0051596 methylglyoxal catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08992-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q10740-1", "uniprot_id": "LKHA4_YEAST", "mass": 77353.0, "length": 671, "protein_name": "Leucine aminopeptidase 2", "gene_name": "LAP2", "organism": "Yeast", "refseq_name": "bifunctional aminopeptidase/epoxide hydrolase", "refseq_ac": "NP_014353", "gene_names_uniprotkb": "LAP2; N2535", "gene_names_refseq": "LAP2", "protein_names_uniprotkb": "Leucine aminopeptidase 2; 3.3.2.10; 3.4.11.-; AP IV; Epoxide hydrolase; LTA-4 hydrolase; Leucyl aminopeptidase yscIV; Leukotriene A-4 hydrolase homolog", "protein_names_refseq": "bifunctional aminopeptidase/epoxide hydrolase", "tax_id": 559292, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); asthma (Disease Ontology:DOID:2841); adenocarcinoma (Disease Ontology:DOID:299)", "pathway": " (sce:YNL045W); (R-SCE-2142691); (R-SCE-6798695); (R-SCE-9018676); (R-SCE-9018681); (R-SCE-9018896); (R-SCE-9020265); (R-SCE-9023661)", "pathway_count": 8, "publication_count": 16, "publication_id_list": "10574934;11601994;12777785;14562095;14562106;16024909;16597475;18407956;19779198;21146536;24374639;33481703;33491328;6352682;8740423;9169873", "class_list": "", "function": "Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1D4", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;3.4.19.12;3.5.1.3;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.2.1.14;3.5.4.5;3.4.11.-;3.3.2.10", "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0004301 epoxide hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0043171 peptide catabolic process;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q10740-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12001-1", "uniprot_id": "ALG6_YEAST", "mass": 62783.0, "length": 544, "protein_name": "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase", "gene_name": "ALG6", "organism": "Yeast", "refseq_name": "dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase", "refseq_ac": "NP_014644", "gene_names_uniprotkb": "ALG6; UNA544", "gene_names_refseq": "ALG6", "protein_names_uniprotkb": "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; 2.4.1.267; Asparagine-linked glycosylation protein 6; Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase", "protein_names_refseq": "dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase", "tax_id": 559292, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ic (Disease Ontology:DOID:0080555)", "pathway": " (sce:YOR002W); (R-SCE-446193)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16847258;17322287;24374639;8877369;8896276;9169874", "class_list": "", "function": "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Man(9)GlcNAc(2)-PP-Dol to produce Glc(1)Man(9)GlcNAc(2)-PP-Dol., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W268;E9P8Y7", "ec_number_list": "2.4.1.267", "go_molecular_function": "GO:0042281 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12001-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12003-1", "uniprot_id": "ENV7_YEAST", "mass": 40749.0, "length": 364, "protein_name": "Serine/threonine-protein kinase ENV7", "gene_name": "ENV7", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase ENV7", "refseq_ac": "NP_015088", "gene_names_uniprotkb": "ENV7", "gene_names_refseq": "ENV7", "protein_names_uniprotkb": "Serine/threonine-protein kinase ENV7; 2.7.11.1; Late endosome and vacuole interface protein 7", "protein_names_refseq": "putative serine/threonine protein kinase ENV7", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL236C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11062466;14562095;16751107;18407956;21912603;24374639;32647006;33491328;9169875", "class_list": "", "function": "Serine/threonine-protein kinase involved in vacuolar processing and morphology., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3D4;Q7LGU7", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0032889 regulation of vacuole fusion, non-autophagic;GO:0006624 vacuolar protein processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q12003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12006-1", "uniprot_id": "PFA4_YEAST", "mass": 44488.0, "length": 378, "protein_name": "Palmitoyltransferase PFA4", "gene_name": "PFA4", "organism": "Yeast", "refseq_name": "palmitoyltransferase PFA4", "refseq_ac": "NP_014640", "gene_names_uniprotkb": "PFA4; UNE378", "gene_names_refseq": "PFA4", "protein_names_uniprotkb": "Palmitoyltransferase PFA4; 2.3.1.225; PAT; Protein S-acyltransferase; Protein fatty acyltransferase 4", "protein_names_refseq": "palmitoyltransferase PFA4", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL003C); (R-SCE-203615)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12379641;15973437;16186255;16751107;16818716;16847258;17322287;21126336;24374639;26224664;28346351;33481703;33491328;8896276;9169874", "class_list": "", "function": "Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. Palmitoylates several amino acid permeases (PubMed:16751107). Palmitoylates chitin synthase CHS3, which is required for its proper export from the ER (PubMed:16818716, PubMed:28346351). Can palmitoylate RAS2 in vitro (PubMed:12379641)., [UniProtKB, PubMed, PubMed, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W264", "ec_number_list": "1.6.2.4;2.3.1.225", "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0018345 protein palmitoylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q12006-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12009-1", "uniprot_id": "TRMB_YEAST", "mass": 33391.0, "length": 286, "protein_name": "tRNA (guanine-N(7)-)-methyltransferase", "gene_name": "TRM8", "organism": "Yeast", "refseq_name": "tRNA (guanine46-N7)-methyltransferase", "refseq_ac": "NP_010080", "gene_names_uniprotkb": "TRM8; D1075", "gene_names_refseq": "TRM8", "protein_names_uniprotkb": "tRNA (guanine-N(7)-)-methyltransferase; 2.1.1.33; Transfer RNA methyltransferase 8; tRNA (guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase", "protein_names_refseq": "tRNA (guanine46-N7)-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL201W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12403464;14562095;14562106;15811913;16387656;17330950;17382321;17563356;18184583;18407956;19779198;19795423;19823750;22814378;23749301;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRF3", "ec_number_list": "2.1.1.33", "go_molecular_function": "GO:0000049 tRNA binding;GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043527 tRNA methyltransferase complex;GO:0106143 tRNA (m7G46) methyltransferase complex", "go_biological_process": "GO:0036265 RNA (guanine-N7)-methylation;GO:0030488 tRNA methylation;GO:0106004 tRNA (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q12009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12017-1", "uniprot_id": "PLP2_YEAST", "mass": 32793.0, "length": 286, "protein_name": "Phosducin-like protein 2", "gene_name": "PLP2", "organism": "Yeast", "refseq_name": "Plp2p", "refseq_ac": "NP_014924", "gene_names_uniprotkb": "PLP2; VIAF1", "gene_names_refseq": "PLP2", "protein_names_uniprotkb": "Phosducin-like protein 2; Viral IAP-associated factor 1 homolog", "protein_names_refseq": "Plp2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR281C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10749875;14562095;14562106;15371430;15665377;17287358;17322287;17330950;17429077;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;8896271;9169874", "class_list": "", "function": "Essential for cell growth (PubMed:10749875). Inhibits early G protein signaling events following pheromone stimulation (PubMed:10749875). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) CCT2 which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Plays a role in cell cycle progression in G1/S phase (PubMed:17429077)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Y0", "ec_number_list": "", "go_molecular_function": "GO:0003779 actin binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0006457 protein folding;GO:0009968 negative regulation of signal transduction;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q12017-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12024-1", "uniprot_id": "YTM1_YEAST", "mass": 51359.0, "length": 460, "protein_name": "Ribosome biogenesis protein YTM1", "gene_name": "YTM1", "organism": "Yeast", "refseq_name": "Ytm1p", "refseq_ac": "NP_014915", "gene_names_uniprotkb": "YTM1", "gene_names_refseq": "CST14; YTM1", "protein_names_uniprotkb": "Ribosome biogenesis protein YTM1; Microtubule-associated protein YTM1", "protein_names_refseq": "Ytm1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR272W); (R-SCE-6791226); (R-SCE-983168)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "12110181;14562095;14562106;16287855;18407956;18448671;20542003;22814378;24374639;26601951;26657628;33481703;33491328;8896271;9169874", "class_list": "", "function": "Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, PubMed, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2X2", "ec_number_list": "", "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0051276 chromosome organization;GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q12024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12039-1", "uniprot_id": "HMI1_YEAST", "mass": 80576.0, "length": 706, "protein_name": "ATP-dependent DNA helicase HMI1, mitochondrial", "gene_name": "HMI1", "organism": "Yeast", "refseq_name": "ATP-dependent 3'-5' DNA helicase", "refseq_ac": "NP_014546", "gene_names_uniprotkb": "HMI1; O0920", "gene_names_refseq": "HMI1", "protein_names_uniprotkb": "ATP-dependent DNA helicase HMI1, mitochondrial; 5.6.2.4; DNA 3'-5' helicase", "protein_names_refseq": "ATP-dependent 3'-5' DNA helicase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL095C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10409639;10669756;1346062;19779198;24374639;7502582;8533473;9169874", "class_list": "", "function": "Required for mitochondrial genome maintenance and mitochondrial DNA inheritance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1X3;Q05379", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0000725 recombinational repair;GO:0032042 mitochondrial DNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12039-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12041-1", "uniprot_id": "MET32_YEAST", "mass": 21518.0, "length": 191, "protein_name": "Transcriptional regulator MET32", "gene_name": "MET32", "organism": "Yeast", "refseq_name": "Met32p", "refseq_ac": "NP_010539", "gene_names_uniprotkb": "MET32; YD9320A.03C", "gene_names_refseq": "MET32", "protein_names_uniprotkb": "Transcriptional regulator MET32; Methionine-requiring protein 32", "protein_names_refseq": "Met32p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR253C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562095;17322287;24374639;9169867;9799240", "class_list": "", "function": "Auxiliary transcriptional regulator of sulfur amino acid metabolism. Involved in the transcriptional activation of MET28., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSN3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q12041-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12055-1", "uniprot_id": "KAD6_YEAST", "mass": 22723.0, "length": 197, "protein_name": "Adenylate kinase isoenzyme 6 homolog FAP7", "gene_name": "FAP7", "organism": "Yeast", "refseq_name": "nucleoside-triphosphatase", "refseq_ac": "NP_010115", "gene_names_uniprotkb": "FAP7", "gene_names_refseq": "FAP7", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 6 homolog FAP7; 2.7.4.3; AK/ATPase; AK6; Dual activity adenylate kinase/ATPase; POS9-activating factor 7", "protein_names_refseq": "nucleoside-triphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL166C); (R-SCE-499943)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10692169;11875433;12837249;14562095;14562106;16287850;17322287;18407956;19684113;19779198;19795423;19823750;20702584;22770215;23749301;24374639;24823650;28890337;33481703;33491328;9169867", "class_list": "", "function": "Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity (PubMed:24823650). Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. Required for cleavage of the 20S pre-rRNA at site D in the cytoplasm (PubMed:12837249, PubMed:16287850, PubMed:22770215). While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit (PubMed:24823650). Promotes formation of the rotated state in 80S-like ribosomes, a key intermediate in translocation, thereby releasing the essential assembly factor DIM1 from pre-40S subunits (PubMed:28890337). Its NMP activity may have a role in nuclear energy homeostasis (PubMed:24823650). Involved in oxidative stress response. Required for POS9-dependent target gene transcription upon oxidative stress (PubMed:10692169)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRI5;E9P8W4", "ec_number_list": "3.6.4.13;5.6.2.3;2.7.4.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q12055-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12063-1", "uniprot_id": "UPPS_YEAST", "mass": 42557.0, "length": 375, "protein_name": "Dehydrodolichyl diphosphate synthase complex subunit NUS1", "gene_name": "NUS1", "organism": "Yeast", "refseq_name": "ditrans,polycis-polyprenyl diphosphate synthase", "refseq_ac": "NP_010088", "gene_names_uniprotkb": "NUS1; D1239", "gene_names_refseq": "NUS1", "protein_names_uniprotkb": "Dehydrodolichyl diphosphate synthase complex subunit NUS1; 2.5.1.87; Nuclear undecaprenyl pyrophosphate synthase 1", "protein_names_refseq": "ditrans,polycis-polyprenyl diphosphate synthase", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 55 (Disease Ontology:DOID:0080227); congenital disorder of glycosylation Iaa (Disease Ontology:DOID:0080553); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (sce:YDL193W); (R-SCE-446199)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10515935;11086160;14562095;14690591;17563356;18407956;20702584;21126336;22118465;23749301;24374639;25066056;33481703;33491328;34965436;8533471;9169867", "class_list": "", "function": "With SRT1 or RER2, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRG0", "ec_number_list": "2.5.1.87", "go_molecular_function": "GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q12063-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12088-1", "uniprot_id": "YL11B_YEAST", "mass": 198462.0, "length": 1755, "protein_name": "Transposon Ty1-LR1 Gag-Pol polyprotein", "gene_name": "TY1B-LR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_013136", "gene_names_uniprotkb": "TY1B-LR1; L1807; YLRCTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-LR1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR035C-A)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169871;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VY38", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q12088-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12092-1", "uniprot_id": "ATG29_YEAST", "mass": 24708.0, "length": 213, "protein_name": "Autophagy-related protein 29", "gene_name": "ATG29", "organism": "Yeast", "refseq_name": "Atg29p", "refseq_ac": "NP_015159", "gene_names_uniprotkb": "ATG29; P2540", "gene_names_refseq": "ATG29", "protein_names_uniprotkb": "Autophagy-related protein 29", "protein_names_refseq": "Atg29p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL166W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562095;14562106;16289106;17700056;18287526;18407956;19337029;19755117;19779198;19793921;23749301;24374639;31553916;33481703;33491328;34965436;8948103;9169875", "class_list": "", "function": "Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3K2", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000407 phagophore assembly site;GO:1990316 Atg1/ULK1 kinase complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0042594 response to starvation;GO:0016236 macroautophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q12092-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12094-1", "uniprot_id": "TSR3_YEAST", "mass": 35686.0, "length": 313, "protein_name": "18S rRNA aminocarboxypropyltransferase", "gene_name": "TSR3", "organism": "Yeast", "refseq_name": "ribosome biogenesis protein TSR3", "refseq_ac": "NP_014648", "gene_names_uniprotkb": "TSR3; UND313", "gene_names_refseq": "TSR3", "protein_names_uniprotkb": "18S rRNA aminocarboxypropyltransferase; 2.5.1.157; 20S rRNA accumulation protein 3; ScTsr3", "protein_names_refseq": "ribosome biogenesis protein TSR3", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR006C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562095;14562106;17330950;17563356;19684113;19779198;19795423;19806183;19823750;21126336;22218487;23749301;24374639;27084949;32597660;33491328;8896276;9169874", "class_list": "", "function": "Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA (PubMed:27084949). It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA (PubMed:27084949). Required for processing 35S pre-rRNA at site D (PubMed:19806183)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W272", "ec_number_list": "2.5.1.157", "go_molecular_function": "GO:1904047 S-adenosyl-L-methionine binding;GO:0106388 rRNA small subunit aminocarboxypropyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q12094-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12099-1", "uniprot_id": "FAL1_YEAST", "mass": 45213.0, "length": 399, "protein_name": "ATP-dependent RNA helicase FAL1", "gene_name": "FAL1", "organism": "Yeast", "refseq_name": "ATP-dependent RNA helicase FAL1", "refseq_ac": "NP_010304", "gene_names_uniprotkb": "FAL1; PZC399; YD9335.07", "gene_names_refseq": "FAL1", "protein_names_uniprotkb": "ATP-dependent RNA helicase FAL1; 3.6.4.13; Translation initiation factor four A-like protein 1", "protein_names_refseq": "ATP-dependent RNA helicase FAL1", "tax_id": 559292, "disease": "intellectual disability (Disease Ontology:DOID:1059); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (sce:YDR021W); (R-SCE-429947); (R-SCE-975957)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "14562095;14562106;17322287;24374639;33491328;8896275;9169867;9372960", "class_list": "", "function": "ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VS07", "ec_number_list": "3.6.5.-;3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.1.3.16;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.1.13.4;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0071013 catalytic step 2 spliceosome;GO:0030688 preribosome, small subunit precursor;GO:0097078 FAL1-SGD1 complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12099-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12100-1", "uniprot_id": "RTK1_YEAST", "mass": 69615.0, "length": 620, "protein_name": "Probable serine/threonine-protein kinase RTK1", "gene_name": "RTK1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase RTK1", "refseq_ac": "NP_010259", "gene_names_uniprotkb": "RTK1; D2810", "gene_names_refseq": "RTK1", "protein_names_uniprotkb": "Probable serine/threonine-protein kinase RTK1; 2.7.11.1; Ribosome biogenesis and tRNA synthetase-associated kinase 1", "protein_names_refseq": "putative serine/threonine protein kinase RTK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL025C); (R-SCE-176187); (R-SCE-5693616); (R-SCE-69601)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "14562106;17322287;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;21177495;22106047;23749301;24374639;30516470;32597660;33229814;33481703;33491328;34965436;9020587;9169867;9990050", "class_list": "", "function": "Probable serine/threonine-protein kinase that may be involved in ribosome biogenesis., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 14, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 14, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 14, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "D6VRW6", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.48;2.7.11.13;3.6.4.-;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0071944 cell periphery;GO:0005935 cellular bud neck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q12100-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12102-1", "uniprot_id": "CFT2_YEAST", "mass": 96254.0, "length": 859, "protein_name": "Cleavage factor two protein 2", "gene_name": "CFT2", "organism": "Yeast", "refseq_name": "cleavage polyadenylation factor subunit CFT2", "refseq_ac": "NP_013216", "gene_names_uniprotkb": "CFT2; L2946; YDH1", "gene_names_refseq": "CFT2; YDH1", "protein_names_uniprotkb": "Cleavage factor two protein 2; 105 kDa protein associated with polyadenylation factor I", "protein_names_refseq": "cleavage polyadenylation factor subunit CFT2", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR115W); (R-SCE-77595)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11406596;12819204;12853609;14562095;14562106;17128255;23749301;24374639;33481703;33491328;9090053;9099738;9169871", "class_list": "", "function": "RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYB3;Q7LGW6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12102-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12106-1", "uniprot_id": "MCP1_YEAST", "mass": 33989.0, "length": 302, "protein_name": "Mitochondrial adapter protein MCP1", "gene_name": "MCP1", "organism": "Yeast", "refseq_name": "Mcp1p", "refseq_ac": "NP_014871", "gene_names_uniprotkb": "MCP1; YOR50-18", "gene_names_refseq": "MCP1", "protein_names_uniprotkb": "Mitochondrial adapter protein MCP1; MDM10-complementing protein 1", "protein_names_refseq": "Mcp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR228C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;16407407;17322287;23781023;24374639;28864540;30018089;34830155;8840505;9169874", "class_list": "", "function": "Recruits the lipid transfer protein Vps13 to mitochondria thereby promoting vacuole-mitochondria contacts (PubMed:28864540, PubMed:30018089, PubMed:34830155). Involved in mitochondrial lipid homeostasis (PubMed:23781023, PubMed:28864540)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2T2", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0055088 lipid homeostasis;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q12106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12112-1", "uniprot_id": "YN11B_YEAST", "mass": 198998.0, "length": 1755, "protein_name": "Transposon Ty1-NL1 Gag-Pol polyprotein", "gene_name": "TY1B-NL1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058178", "gene_names_uniprotkb": "TY1B-NL1; N0564; YNLCTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-NL1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL284C-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169873;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Q8", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q12112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12113-1", "uniprot_id": "YO21B_YEAST", "mass": 201984.0, "length": 1770, "protein_name": "Transposon Ty2-OR1 Gag-Pol polyprotein", "gene_name": "TY2B-OR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058185", "gene_names_uniprotkb": "TY2B-OR1; O4785; YORCTy2-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty2-OR1 Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR192C-B)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16093660;24374639;9169874;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Q0", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q12113-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12123-1", "uniprot_id": "DCS2_YEAST", "mass": 40941.0, "length": 353, "protein_name": "Inactive diphosphatase DCS2", "gene_name": "DCS2", "organism": "Yeast", "refseq_name": "5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase", "refseq_ac": "NP_014816", "gene_names_uniprotkb": "DCS2; O3625", "gene_names_refseq": "DCS2", "protein_names_uniprotkb": "Inactive diphosphatase DCS2; Histidine triad protein; Protein Dcs2p", "protein_names_refseq": "5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR173W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12198172;14562095;14562106;15240832;15273322;16963086;17563356;18407956;19779198;19795423;19823750;20702584;21177495;22814378;23749301;24374639;24909858;32597660;33481703;33491328;8972579;9169874", "class_list": "", "function": "Plays a role in the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Stress-induced regulatory protein that modulates the m7GpppX diphosphatase activity of DCS1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2M9", "ec_number_list": "", "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000340 RNA 7-methylguanosine cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0031670 cellular response to nutrient;GO:0006970 response to osmotic stress;GO:0006979 response to oxidative stress;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q12123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12124-1", "uniprot_id": "MED2_YEAST", "mass": 47718.0, "length": 431, "protein_name": "Mediator of RNA polymerase II transcription subunit 2", "gene_name": "MED2", "organism": "Yeast", "refseq_name": "Med2p", "refseq_ac": "NP_010279", "gene_names_uniprotkb": "MED2; D2930", "gene_names_refseq": "MED2", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 2; Mediator complex subunit 2", "protein_names_refseq": "Med2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL005C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "12191485;14562095;14562106;14988503;15175151;15477388;16002404;16076843;16109375;16263706;17192271;17322287;18407956;22218487;23749301;24374639;32597660;33229814;33481703;33491328;9169867;9420330", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VRY3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034976 response to endoplasmic reticulum stress;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q12124-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12127-1", "uniprot_id": "CCW12_YEAST", "mass": 13058.0, "length": 133, "protein_name": "Covalently-linked cell wall protein 12", "gene_name": "CCW12", "organism": "Yeast", "refseq_name": "Ccw12p", "refseq_ac": "NP_013211", "gene_names_uniprotkb": "CCW12; L9354.7", "gene_names_refseq": "CCW12", "protein_names_uniprotkb": "Covalently-linked cell wall protein 12; Protein Alpha0.6", "protein_names_refseq": "Ccw12p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR110C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10322008;14562106;15165243;17315267;17322287;22106047;24374639;9090053;9169871;9234669;9613572", "class_list": "", "function": "Component of the cell wall. May play a role in the formation of a tightly packed outer mannan layer, which protects the inner glucan., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 12, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "D6VYB0", "ec_number_list": "", "go_molecular_function": "GO:0005199 structural constituent of cell wall", "go_cellular_component": "GO:0071944 cell periphery;GO:0000324 fungal-type vacuole;GO:0005934 cellular bud tip;GO:0009277 fungal-type cell wall;GO:0043332 mating projection tip", "go_biological_process": "GO:0000752 agglutination involved in conjugation with cellular fusion;GO:0000747 conjugation with cellular fusion;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q12127-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12141-1", "uniprot_id": "YG11B_YEAST", "mass": 198658.0, "length": 1755, "protein_name": "Transposon Ty1-GR1 Gag-Pol polyprotein", "gene_name": "TY1B-GR1", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058158", "gene_names_uniprotkb": "TY1B-GR1; G4054; YGRWTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-GR1 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR027W-B)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;16093680;17287358;24374639;9169869;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VUG1", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12141-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12142-1", "uniprot_id": "ATG9_YEAST", "mass": 115403.0, "length": 997, "protein_name": "Autophagy-related protein 9", "gene_name": "ATG9", "organism": "Yeast", "refseq_name": "autophagy protein ATG9", "refseq_ac": "NP_010132", "gene_names_uniprotkb": "ATG9; APG9; AUT9; CVT7; D1560", "gene_names_refseq": "APG9; ATG9; AUT9; CVT6; CVT7", "protein_names_uniprotkb": "Autophagy-related protein 9; Cytoplasm to vacuole targeting protein 7", "protein_names_refseq": "autophagy protein ATG9", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YDL149W); (R-SCE-1632852)", "pathway_count": 2, "publication_count": 59, "publication_id_list": "10662773;10735854;11382760;11689437;14504273;14536056;14723849;15138258;16787937;16847258;16874040;17132049;17135291;17178909;17192412;17295840;17329962;17426440;18287533;18407956;18625846;18818209;18829864;19371383;19779198;20065092;20444978;20444982;20855505;20861302;21576396;21784249;22144692;22447937;22509044;22826123;22977244;23129774;23549786;23749301;24374639;24440502;24905091;26565778;27050455;31356628;32597660;32883836;33106658;33439214;33443148;33481703;33491328;34965436;7593182;8224160;8663607;8972581;9169867", "class_list": "", "function": "Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation (PubMed:10735854, PubMed:14504273, PubMed:24440502, PubMed:27050455, PubMed:33106658, PubMed:33439214, PubMed:7593182, PubMed:8224160, PubMed:8663607). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:10662773, PubMed:11689437, PubMed:17329962, PubMed:17426440, PubMed:18829864, PubMed:22826123, PubMed:24905091, PubMed:33439214). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:32883836, PubMed:33106658, PubMed:33439214). Required for mitophagy (PubMed:18818209). Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (PubMed:17132049). Recruits vesicle-tethering proteins TRS85 and YPT1 to the autophagosome formation site (PubMed:23129774). Also recruits ATG23 and ATG8 to the PAS (PubMed:14504273)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 28, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRJ9", "ec_number_list": "", "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0045332 phospholipid translocation;GO:0006914 autophagy;GO:0034497 protein localization to phagophore assembly site;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 6.0, "record_id": "Q12142-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12151-1", "uniprot_id": "UPC2_YEAST", "mass": 100340.0, "length": 913, "protein_name": "Sterol uptake control protein 2", "gene_name": "UPC2", "organism": "Yeast", "refseq_name": "Upc2p", "refseq_ac": "NP_010499", "gene_names_uniprotkb": "UPC2; MOX4; YD8142.14; YD8142B.05", "gene_names_refseq": "MOX4; UPC2", "protein_names_uniprotkb": "Sterol uptake control protein 2; Mannoprotein regulation by oxygen protein 4", "protein_names_refseq": "Upc2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR213W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11238402;11292809;11533229;12077145;12673627;14562095;14562106;17563356;18407956;19779198;21177495;23749301;24374639;3059715;32597660;33481703;33491328;9169867;9696767", "class_list": "", "function": "Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c. Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes. Involved in sterol uptake and regulation of the sterol biosynthesis. Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters. May be involved in down-regulation of CWP2 during anaerobic adaptation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSJ7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071456 cellular response to hypoxia;GO:0070452 positive regulation of ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q12151-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12157-1", "uniprot_id": "APC11_YEAST", "mass": 18865.0, "length": 165, "protein_name": "Anaphase-promoting complex subunit 11", "gene_name": "APC11", "organism": "Yeast", "refseq_name": "anaphase promoting complex subunit 11", "refseq_ac": "NP_010276", "gene_names_uniprotkb": "APC11; D2900", "gene_names_refseq": "APC11", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 11; 6.3.2.-", "protein_names_refseq": "anaphase promoting complex subunit 11", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL008W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10888670;14562106;24374639;33491328;9169867;9469814", "class_list": "", "function": "Probably catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication. APC11 is required to recruit the ubiquitin-conjugating enzyme E2 to the APC/C., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRX9", "ec_number_list": "2.3.2.23;2.3.2.27;6.2.1.45;2.3.2.-;2.3.2.26;2.3.2.31;1.14.11.27;2.3.2.34;6.3.2.-", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0097602 cullin family protein binding;GO:0016874 ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0045842 positive regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12157-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12173-1", "uniprot_id": "YG31A_YEAST", "mass": 34027.0, "length": 290, "protein_name": "Transposon Ty3-G Gag polyprotein", "gene_name": "TY3A-G", "organism": "Yeast", "refseq_name": "gag protein", "refseq_ac": "NP_058162", "gene_names_uniprotkb": "TY3A-G; G5982; YGRWTy3-1 GAG", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty3-G Gag polyprotein; Gag3; TY3A; Transposon Ty3-1 protein A; p24; p7", "protein_names_refseq": "gag protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR109W-A)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10593967;1371165;15956549;16093660;17322287;2159534;24374639;2447089;7515969;7677953;8905931;9169869;9582191;9707446", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome., [UniProtKB]; Nucleocapsid protein p9 (NC) forms the nucleocore that coats the retro-elements dimeric RNA. Binds these RNAs through its zinc fingers (By similarity). Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUP2;Q07096;Q9P311", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000943 retrotransposon nucleocapsid", "go_biological_process": "GO:0032197 retrotransposition;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q12173-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12178-1", "uniprot_id": "FCY1_YEAST", "mass": 17507.0, "length": 158, "protein_name": "Cytosine deaminase", "gene_name": "FCY1", "organism": "Yeast", "refseq_name": "cytosine deaminase", "refseq_ac": "NP_015387", "gene_names_uniprotkb": "FCY1; YP9499.17", "gene_names_refseq": "FCY1", "protein_names_uniprotkb": "Cytosine deaminase; 3.5.4.1; Cytosine aminohydrolase; Fluorocytosine resistance protein 1; yCD", "protein_names_refseq": "cytosine deaminase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR062W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10501935;12637534;12906827;14562095;14562106;15535715;15823054;15879217;24374639;9000374;9169875", "class_list": "", "function": "Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W467", "ec_number_list": "3.5.4.1", "go_molecular_function": "GO:0004131 cytosine deaminase activity;GO:0008270 zinc ion binding;GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008655 pyrimidine-containing compound salvage;GO:0019858 cytosine metabolic process;GO:0044206 UMP salvage;GO:0046087 cytidine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12184-1", "uniprot_id": "ADRX_YEAST", "mass": 18932.0, "length": 172, "protein_name": "Adrenodoxin homolog, mitochondrial", "gene_name": "YAH1", "organism": "Yeast", "refseq_name": "adrenodoxin", "refseq_ac": "NP_015071", "gene_names_uniprotkb": "YAH1", "gene_names_refseq": "YAH1", "protein_names_uniprotkb": "Adrenodoxin homolog, mitochondrial; Mitochondrial ferredoxin", "protein_names_refseq": "adrenodoxin", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL252C); (R-SCE-1362409); (R-SCE-2395516); (R-SCE-9857492)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10375636;10655482;11248251;11788607;12970193;14562106;15211518;20534343;21944752;24374639;25358379;27738674;9169875", "class_list": "", "function": "Iron-sulfur protein that transfers electrons in a wide variety of metabolic reactions. Involved in heme A biosynthesis and in iron-sulfur cluster assembly (PubMed:10655482). Transfers electrons from adrenodoxin reductase ARH1 to heme A synthase COX15, a heme protein that catalyzes the conversion of heme O to heme A (PubMed:11248251, PubMed:11788607). Required for the de novo synthesis of Fe-S clusters on iron sulfur cluster assembly protein ISU1. Interact in its reduced state with ISU1 to productively deliver electrons for Fe-S cluster synthesis (PubMed:12970193, PubMed:15211518, PubMed:25358379). Essential for coenzyme Q biosynthesis. May transfer the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:20534343, PubMed:21944752)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3B9", "ec_number_list": "", "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006744 ubiquinone biosynthetic process;GO:0022900 electron transport chain;GO:0006784 heme A biosynthetic process;GO:0140647 P450-containing electron transport chain", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12184-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12188-1", "uniprot_id": "REC8_YEAST", "mass": 77202.0, "length": 680, "protein_name": "Meiotic recombination protein REC8", "gene_name": "REC8", "organism": "Yeast", "refseq_name": "Rec8p", "refseq_ac": "NP_015332", "gene_names_uniprotkb": "REC8; LPZ7C; SPO69", "gene_names_refseq": "REC8; SPO69", "protein_names_uniprotkb": "Meiotic recombination protein REC8; Cohesin REC8; Sporulation protein 69", "protein_names_refseq": "Rec8p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR007C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10412984;10691741;11081626;11163190;12101124;12663816;12665553;12717442;15062096;15120066;15620644;15819623;16027219;16269332;16672979;20230747;24374639;2996783;30417519;30605471;9169875;9784122", "class_list": "", "function": "Replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis (PubMed:10412984, PubMed:10691741, PubMed:11081626, PubMed:11163190, PubMed:12101124, PubMed:12663816, PubMed:12665553, PubMed:12717442, PubMed:15062096, PubMed:15120066, PubMed:15819623, PubMed:16027219, PubMed:9784122). Is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate (PubMed:11081626). Is protected from cleavage by SPO13 (PubMed:15620644). Promotes localization of the LINC complex subunit MPS3 on nuclear envelope in mitotic cells (PubMed:30417519)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W418", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0008278 cohesin complex;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0006302 double-strand break repair;GO:0007130 synaptonemal complex assembly;GO:0042138 meiotic DNA double-strand break formation;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q12188-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12191-1", "uniprot_id": "BUG1_YEAST", "mass": 38295.0, "length": 341, "protein_name": "Binder of USO1 and GRH1 protein 1", "gene_name": "BUG1", "organism": "Yeast", "refseq_name": "Bug1p", "refseq_ac": "NP_010184", "gene_names_uniprotkb": "BUG1", "gene_names_refseq": "BUG1", "protein_names_uniprotkb": "Binder of USO1 and GRH1 protein 1", "protein_names_refseq": "Bug1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL099W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "14562095;14562106;16269340;17261844;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22814378;23749301;24374639;24909858;30516470;32597660;33481703;33491328;34965436;8923743;9169867", "class_list": "", "function": "Involved in ER to Golgi vesicle-mediated transport by either facilitating USO1-dependent and -independent tethering or increasing target accuracy of fusion events of COPII-coated vesicles., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRQ1", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005801 cis-Golgi network;GO:0033106 cis-Golgi network membrane", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q12191-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12193-1", "uniprot_id": "YB12B_YEAST", "mass": 198869.0, "length": 1756, "protein_name": "Transposon Ty1-BR Gag-Pol polyprotein", "gene_name": "TY1B-BR", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_009567", "gene_names_uniprotkb": "TY1B-BR; YBR0207; YBRWTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-BR Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR012W-B)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16093660;16093680;17287358;17330950;19779198;24374639;7813418;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ13", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12193-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12198-1", "uniprot_id": "METW_YEAST", "mass": 64223.0, "length": 575, "protein_name": "Homocysteine/cysteine synthase", "gene_name": "HSU1", "organism": "Yeast", "refseq_name": "cystathionine gamma-synthase", "refseq_ac": "NP_013042", "gene_names_uniprotkb": "HSU1; L0569", "gene_names_refseq": "HSU1", "protein_names_uniprotkb": "Homocysteine/cysteine synthase; 2.5.1.47; 2.5.1.49; Hydrogen sulfide utilizing 1; O-acetylserine/O-acetylhomoserine sulfhydrylase; OAS-OAH SHLase; OAS-OAH sulfhydrylase", "protein_names_refseq": "cystathionine gamma-synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL058W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562106;24374639;36379252;36455053;9169871", "class_list": "", "function": "Plays a role in inorganic sulfur assimilation during sulfur-limited conditions; catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (PubMed:36379252, PubMed:36455053). Also catalyzes the conversion of O-acetylserine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway (PubMed:36455053). However, it seems that in S.cerevisiae cysteine biosynthesis occurs exclusively through the cystathionine pathway and not via direct incorporation of sulfur into OAS (By similarity). It therefore has no metabolic role in cysteine biosynthesis and may only have a regulatory role controlling OAS levels (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXV0", "ec_number_list": "2.5.1.47;2.5.1.49", "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003962 cystathionine gamma-synthase activity;GO:0004124 cysteine synthase activity;GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity;GO:0051009 O-acetylhomoserine sulfhydrylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006790 sulfur compound metabolic process;GO:0019346 transsulfuration;GO:0000103 sulfate assimilation;GO:0006791 sulfur utilization;GO:0071269 L-homocysteine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q12198-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12206-1", "uniprot_id": "WTM2_YEAST", "mass": 51951.0, "length": 467, "protein_name": "Transcriptional modulator WTM2", "gene_name": "WTM2", "organism": "Yeast", "refseq_name": "transcriptional modulator", "refseq_ac": "NP_014872", "gene_names_uniprotkb": "WTM2; YOR50-19", "gene_names_refseq": "WTM2", "protein_names_uniprotkb": "Transcriptional modulator WTM2", "protein_names_refseq": "transcriptional modulator", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR229W); (R-SCE-3214815)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;17563356;19779198;19795423;19823750;22814378;24374639;32597660;33491328;8840505;9169874", "class_list": "", "function": "Transcriptional modulator with roles in meiotic regulation and silencing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2T3", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070210 Rpd3L-Expanded complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12206-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12207-1", "uniprot_id": "NCE2_YEAST", "mass": 18967.0, "length": 173, "protein_name": "Non-classical export protein 2", "gene_name": "NCE102", "organism": "Yeast", "refseq_name": "Nce102p", "refseq_ac": "NP_015475", "gene_names_uniprotkb": "NCE102; NCE2; P9659.2; RTG2S2", "gene_names_refseq": "NCE102; NCE2", "protein_names_uniprotkb": "Non-classical export protein 2", "protein_names_refseq": "Nce102p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR149W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10716729;12469340;16847258;17322287;17415679;19064668;19564405;19779198;20581291;22814378;23749301;24374639;32597660;33481703;33491328;8655575;9169875", "class_list": "", "function": "Involved in membrane organization. Required for the formation of membrane compartments of CAN1 (MCCs), localization of CAN1 at the MCCs and subsequent invagination of the plasma membrane at the MCCs sites. Involved in eisosome organization and might act as a sensor of sphingolipids that regulates plasma membrane function. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. It may be an accessory subunit to an essential core component of the non-classical export machinery. Non-classical export pathway also functions as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4E6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097576 vacuole fusion;GO:0007009 plasma membrane organization;GO:0072659 protein localization to plasma membrane;GO:0001933 negative regulation of protein phosphorylation;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q12207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12211-1", "uniprot_id": "PUS1_YEAST", "mass": 62143.0, "length": 544, "protein_name": "tRNA pseudouridine synthase 1", "gene_name": "PUS1", "organism": "Yeast", "refseq_name": "pseudouridine synthase PUS1", "refseq_ac": "NP_015112", "gene_names_uniprotkb": "PUS1", "gene_names_refseq": "PUS1", "protein_names_uniprotkb": "tRNA pseudouridine synthase 1; 5.4.99.-; tRNA pseudouridylate synthase 1; tRNA-uridine isomerase 1", "protein_names_refseq": "pseudouridine synthase PUS1", "tax_id": 559292, "disease": "myopathy, lactic acidosis, and sideroblastic anemia (Disease Ontology:DOID:0080099); myopathy, lactic acidosis, and sideroblastic anemia 1 (Disease Ontology:DOID:0111185)", "pathway": " (sce:YPL212C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10356324;11502169;14562106;23749301;24374639;25219674;30377154;31477916;33481703;33491328;8641292;9169875;9585540;9671058", "class_list": "", "function": "Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr) (PubMed:10356324, PubMed:25219674, PubMed:9671058). Catalyzes pseudouridylation at position 44 in U2 snRNA (PubMed:25219674). Also catalyzes pseudouridylation of mRNAs (PubMed:25219674, PubMed:31477916)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3F8", "ec_number_list": "5.4.99.-;5.4.99.25;5.4.99.27", "go_molecular_function": "GO:0003729 mRNA binding;GO:0009982 pseudouridine synthase activity;GO:0106029 tRNA pseudouridine synthase activity;GO:0106032 snRNA pseudouridine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0006400 tRNA modification;GO:0031120 snRNA pseudouridine synthesis;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q12211-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12213-1", "uniprot_id": "RL7B_YEAST", "mass": 27696.0, "length": 244, "protein_name": "Large ribosomal subunit protein uL30B", "gene_name": "RPL7B", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL30 RPL7B", "refseq_ac": "NP_015126", "gene_names_uniprotkb": "RPL7B; RPL6B; YL8B", "gene_names_refseq": "RPL7B", "protein_names_uniprotkb": "Large ribosomal subunit protein uL30B; 60S ribosomal protein L7-B; L6; RP11; YL8", "protein_names_refseq": "60S ribosomal protein uL30 RPL7B", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL198W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11875433;14562095;14562106;15665377;17287358;17330950;20702584;22096102;24374639;24524803;33481703;33491328;34965436;8536309;9169875;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3H1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0002181 cytoplasmic translation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q12213-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12216-1", "uniprot_id": "SIZ2_YEAST", "mass": 81178.0, "length": 726, "protein_name": "E3 SUMO-protein ligase SIZ2", "gene_name": "NFI1", "organism": "Yeast", "refseq_name": "SUMO ligase NFI1", "refseq_ac": "NP_014799", "gene_names_uniprotkb": "NFI1; SIZ2", "gene_names_refseq": "NFI1; SIZ2", "protein_names_uniprotkb": "E3 SUMO-protein ligase SIZ2; 2.3.2.-; E3 SUMO-protein transferase SIZ2; SAP and Miz-finger domain-containing protein 2", "protein_names_refseq": "SUMO ligase NFI1", "tax_id": 559292, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (sce:YOR156C); (R-SCE-3232118); (R-SCE-4085377); (R-SCE-4551638)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "11333221;11587849;12761287;14562106;15166219;18407956;19779198;23749301;24374639;32597660;33481703;33491328;33502312;9046089;9169874", "class_list": "", "function": "May act as an E3 ligase mediating SUMO/Smt3 attachment to septins. May be involved in chromosome maintenance., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2L3", "ec_number_list": "2.3.2.-", "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016925 protein sumoylation;GO:1990683 DNA double-strand break attachment to nuclear envelope", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q12216-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12223-1", "uniprot_id": "RAD59_YEAST", "mass": 26630.0, "length": 238, "protein_name": "DNA repair protein RAD59", "gene_name": "RAD59", "organism": "Yeast", "refseq_name": "Rad59p", "refseq_ac": "NP_010224", "gene_names_uniprotkb": "RAD59", "gene_names_refseq": "RAD59", "protein_names_uniprotkb": "DNA repair protein RAD59", "protein_names_refseq": "Rad59p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL059C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "13679150;14562106;17322287;24374639;8769646;9169867", "class_list": "", "function": "Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRT7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006312 mitotic recombination;GO:2000278 regulation of DNA biosynthetic process;GO:0045002 double-strand break repair via single-strand annealing;GO:0000724 double-strand break repair via homologous recombination;GO:0043504 mitochondrial DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12223-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12224-1", "uniprot_id": "RLM1_YEAST", "mass": 73484.0, "length": 676, "protein_name": "Transcription factor RLM1", "gene_name": "RLM1", "organism": "Yeast", "refseq_name": "Rlm1p", "refseq_ac": "NP_015236", "gene_names_uniprotkb": "RLM1; LPG19C", "gene_names_refseq": "RLM1", "protein_names_uniprotkb": "Transcription factor RLM1", "protein_names_refseq": "Rlm1p", "tax_id": 559292, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language (Disease Ontology:DOID:0070050); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (sce:YPL089C); (R-SCE-525793)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "12410835;14562106;17330950;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21177495;23749301;24374639;30516470;32597660;33481703;33491328;7565726;9111331;9121433;9169875", "class_list": "", "function": "May function as a transcription factor downstream of MPK1 that is subject to activation by the MPK1 mitogen-activated protein kinase pathway. Binds to the DNA sequence 5'-CTA[TA](4)TAG-3'. At least some RML1 target genes are involved in cell wall biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3S8", "ec_number_list": "", "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0046983 protein dimerization activity;GO:0051019 mitogen-activated protein kinase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0033554 cellular response to stress", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q12224-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12236-1", "uniprot_id": "PKH2_YEAST", "mass": 121660.0, "length": 1081, "protein_name": "Serine/threonine-protein kinase PKH2", "gene_name": "PKH2", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase PKH2", "refseq_ac": "NP_014541", "gene_names_uniprotkb": "PKH2; HRC1081", "gene_names_refseq": "PKH2", "protein_names_uniprotkb": "Serine/threonine-protein kinase PKH2; 2.7.11.1; PKB-activating kinase homolog 2", "protein_names_refseq": "serine/threonine protein kinase PKH2", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YOL100W); (R-SCE-114604); (R-SCE-1257604); (R-SCE-165158); (R-SCE-202424); (R-SCE-2730905); (R-SCE-389357); (R-SCE-392451); (R-SCE-5218920); (R-SCE-5218921); (R-SCE-5625740); (R-SCE-6804757); (R-SCE-9634635); (R-SCE-9856530)", "pathway_count": 14, "publication_count": 27, "publication_id_list": "10074427;10567559;11726514;12221112;15470109;17287358;17330950;17563356;18034155;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21163942;21177495;22814378;23749301;23911092;24374639;32597660;33481703;33491328;7502582;9169874", "class_list": "", "function": "Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W1W8", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;3.6.5.2;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0032126 eisosome", "go_biological_process": "GO:0006897 endocytosis;GO:0035556 intracellular signal transduction;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway;GO:0000196 cell integrity MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q12236-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12242-1", "uniprot_id": "RUP1_YEAST", "mass": 75361.0, "length": 671, "protein_name": "UBA domain-containing protein RUP1", "gene_name": "RUP1", "organism": "Yeast", "refseq_name": "Rup1p", "refseq_ac": "NP_014781", "gene_names_uniprotkb": "RUP1; YOR3332c", "gene_names_refseq": "RUP1", "protein_names_uniprotkb": "UBA domain-containing protein RUP1", "protein_names_refseq": "Rup1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR138C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562095;14562106;15933713;17028178;17322287;18407956;19684113;19779198;19795423;19823750;22814378;23749301;24374639;30516470;33491328;9169874;9200815", "class_list": "", "function": "Modulates the activity of the RSP5 HECT ubiquitin-protein ligase through its mediation of the interaction between RSP5 and the deubiquitinase UBP2. Involved in regulation of cell wall homeostasis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2J5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016579 protein deubiquitination;GO:1902499 positive regulation of protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q12242-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12246-1", "uniprot_id": "LCB4_YEAST", "mass": 69639.0, "length": 624, "protein_name": "Sphingoid long chain base kinase 4", "gene_name": "LCB4", "organism": "Yeast", "refseq_name": "sphinganine kinase LCB4", "refseq_ac": "NP_014814", "gene_names_uniprotkb": "LCB4; O3615", "gene_names_refseq": "LCB4", "protein_names_uniprotkb": "Sphingoid long chain base kinase 4; 2.7.1.91; LCB kinase 4; Sphinganine kinase 4", "protein_names_refseq": "sphinganine kinase LCB4", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); adenocarcinoma (Disease Ontology:DOID:299); high grade glioma (Disease Ontology:DOID:3070); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YOR171C); (R-SCE-1660661); (R-SCE-390471); (R-SCE-5218921); (R-SCE-9009391); (R-SCE-9833482)", "pathway_count": 6, "publication_count": 34, "publication_id_list": "11056159;11102354;11278643;11795842;11967828;12459470;12493772;14562106;15598647;16141212;16227572;17330950;17563356;17686782;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21126336;22106047;22218487;22814378;23749301;24374639;25345524;32597660;33481703;33491328;8972579;9169874;9677363", "class_list": "", "function": "Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively (PubMed:11102354, PubMed:11795842, PubMed:16141212, PubMed:25345524, PubMed:9677363). Involved in the biosynthesis of sphingolipids and ceramides (PubMed:12493772). Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest (PubMed:11056159). Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling (PubMed:11278643). Involved in heat-stress resistance (PubMed:11967828)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2M7", "ec_number_list": "2.7.11.13;2.7.1.91", "go_molecular_function": "GO:0005524 ATP binding;GO:0008481 sphingosine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0006665 sphingolipid metabolic process;GO:0046512 sphingosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "Q12246-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12256-1", "uniprot_id": "TPO4_YEAST", "mass": 73223.0, "length": 659, "protein_name": "Polyamine transporter 4", "gene_name": "TPO4", "organism": "Yeast", "refseq_name": "Tpo4p", "refseq_ac": "NP_014916", "gene_names_uniprotkb": "TPO4; O5440", "gene_names_refseq": "TPO4", "protein_names_uniprotkb": "Polyamine transporter 4", "protein_names_refseq": "Tpo4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR273C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11171066;11875433;12562762;14562095;14562106;15066780;16847258;17287358;17330950;18407956;19779198;19795423;19823750;22218487;23749301;24374639;32597660;33481703;33491328;8896271;9169874;9593122", "class_list": "", "function": "Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermidine, spermine and the antimalarial drug quinidine, but not quinine, chloroquine and mefloquine., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2X3", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0015606 spermidine transmembrane transporter activity;GO:0000297 spermine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0000296 spermine transport;GO:0055085 transmembrane transport;GO:0015848 spermidine transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q12256-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12262-1", "uniprot_id": "CENPH_YEAST", "mass": 21138.0, "length": 181, "protein_name": "Inner kinetochore subunit MCM16", "gene_name": "MCM16", "organism": "Yeast", "refseq_name": "Mcm16p", "refseq_ac": "NP_015371", "gene_names_uniprotkb": "MCM16", "gene_names_refseq": "MCM16", "protein_names_uniprotkb": "Inner kinetochore subunit MCM16; CENP-H homolog; Constitutive centromere-associated network protein MCM16; Minichromosome maintenance protein 16", "protein_names_refseq": "Mcm16p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR046W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11782448;12408861;14562095;14562106;22561346;24374639;9169875;9862478", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W454", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12262-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12267-1", "uniprot_id": "SMC4_YEAST", "mass": 162189.0, "length": 1418, "protein_name": "Structural maintenance of chromosomes protein 4", "gene_name": "SMC4", "organism": "Yeast", "refseq_name": "condensin subunit SMC4", "refseq_ac": "NP_013187", "gene_names_uniprotkb": "SMC4; L9449.5", "gene_names_refseq": "SMC4", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 4", "protein_names_refseq": "condensin subunit SMC4", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR086W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10811823;14562106;18407956;19779198;19795423;19823750;21177495;22031224;22814378;23749301;24374639;32597660;33229814;33481703;33491328;9169871", "class_list": "", "function": "Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 42, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VY86", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000796 condensin complex", "go_biological_process": "GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0030261 chromosome condensation;GO:0000070 mitotic sister chromatid segregation;GO:0070550 rDNA chromatin condensation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q12267-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12269-1", "uniprot_id": "YG12B_YEAST", "mass": 198521.0, "length": 1755, "protein_name": "Transposon Ty1-GR2 Gag-Pol polyprotein", "gene_name": "TY1B-GR2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058160", "gene_names_uniprotkb": "TY1B-GR2; G4126; YGRCTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-GR2 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR038C-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169869;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VUH6", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q12269-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12273-1", "uniprot_id": "YO11B_YEAST", "mass": 198614.0, "length": 1755, "protein_name": "Transposon Ty1-OL Gag-Pol polyprotein", "gene_name": "TY1B-OL", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058181", "gene_names_uniprotkb": "TY1B-OL; O0770; YOLWTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-OL Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL103W-B)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;16093680;24374639;7502582;9169874;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W1W3", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12284-1", "uniprot_id": "ERV2_YEAST", "mass": 22141.0, "length": 196, "protein_name": "FAD-linked sulfhydryl oxidase ERV2", "gene_name": "ERV2", "organism": "Yeast", "refseq_name": "flavin-linked sulfhydryl oxidase", "refseq_ac": "NP_015362", "gene_names_uniprotkb": "ERV2; YP3085.03C", "gene_names_refseq": "ERV2", "protein_names_uniprotkb": "FAD-linked sulfhydryl oxidase ERV2; 1.8.3.2", "protein_names_refseq": "flavin-linked sulfhydryl oxidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR037C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11313344;11584268;11740506;14562106;21126336;22814378;24374639;9169875;9483805", "class_list": "", "function": "FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W448", "ec_number_list": "1.8.3.2", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0016972 thiol oxidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0060904 regulation of protein folding in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q12284-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12287-1", "uniprot_id": "COX17_YEAST", "mass": 8056.0, "length": 69, "protein_name": "Cytochrome c oxidase copper chaperone", "gene_name": "COX17", "organism": "Yeast", "refseq_name": "copper metallochaperone COX17", "refseq_ac": "NP_013092", "gene_names_uniprotkb": "COX17; L1343", "gene_names_refseq": "COX17", "protein_names_uniprotkb": "Cytochrome c oxidase copper chaperone", "protein_names_refseq": "copper metallochaperone COX17", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL009C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15199057;15465825;22984289;24374639;8662933;9169871;9407107;9585572", "class_list": "", "function": "Copper metallochaperone involved in the assembly of cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:8662933). Binds two copper ions and delivers them to metallochaperone SCO1, which relays the copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2), and to metallochaperone COX11, which relays the copper to the Cu(B) site on the cytochrome c oxidase subunit I (COX1) (PubMed:15199057, PubMed:8662933, PubMed:9585572)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXZ3", "ec_number_list": "", "go_molecular_function": "GO:1903136 cuprous ion binding;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0018343 protein farnesylation;GO:0006825 copper ion transport;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12287-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12297-1", "uniprot_id": "TAF3_YEAST", "mass": 40296.0, "length": 353, "protein_name": "Transcription initiation factor TFIID subunit 3", "gene_name": "TAF3", "organism": "Yeast", "refseq_name": "Taf3p", "refseq_ac": "NP_015314", "gene_names_uniprotkb": "TAF3; LPA6C; TAF47", "gene_names_refseq": "TAF3; TAF47", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 3; TAFII-47; TAFII47; TBP-associated factor 3; TBP-associated factor 47 kDa", "protein_names_refseq": "Taf3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL011C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10788514;11238921;11295558;12093743;12138208;12516863;14562095;14562106;15665377;17330950;17563356;18407956;19779198;20702584;22218487;2265610;23749301;24374639;3143101;32597660;33481703;33491328;9169875;9695952", "class_list": "", "function": "Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W401", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q12297-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12303-1", "uniprot_id": "YPS3_YEAST", "mass": 54570.0, "length": 508, "protein_name": "Aspartic proteinase yapsin-3", "gene_name": "YPS3", "organism": "Yeast", "refseq_name": "aspartyl protease", "refseq_ac": "NP_013222", "gene_names_uniprotkb": "YPS3; L2964; L9233.10", "gene_names_refseq": "YPS3; YPS4", "protein_names_uniprotkb": "Aspartic proteinase yapsin-3; 3.4.23.-", "protein_names_refseq": "aspartyl protease", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (sce:YLR121C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10191273;11016834;16087741;24374639;9090053;9169871", "class_list": "", "function": "Cleaves proteins C-terminally to mono- and paired-basic residues. Required for cell wall integrity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6VYB9", "ec_number_list": "", "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0016485 protein processing;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12303-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12305-1", "uniprot_id": "RDL1_YEAST", "mass": 15413.0, "length": 139, "protein_name": "Thiosulfate:glutathione sulfurtransferase", "gene_name": "RDL1", "organism": "Yeast", "refseq_name": "thiosulfate sulfurtransferase RDL1", "refseq_ac": "NP_014928", "gene_names_uniprotkb": "RDL1", "gene_names_refseq": "RDL1", "protein_names_uniprotkb": "Thiosulfate:glutathione sulfurtransferase; 2.8.1.-; Rhodanese-like protein 1; TST", "protein_names_refseq": "thiosulfate sulfurtransferase RDL1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR285W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562095;14562106;14576278;16407407;19779198;19795423;19823750;19864628;23749301;24374639;24909858;24981631;33481703;33491328;8896271;9169874", "class_list": "", "function": "Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Y3", "ec_number_list": "2.8.1.-", "go_molecular_function": "GO:0004792 thiosulfate-cyanide sulfurtransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q12305-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12311-1", "uniprot_id": "NTO1_YEAST", "mass": 86029.0, "length": 748, "protein_name": "NuA3 HAT complex component NTO1", "gene_name": "NTO1", "organism": "Yeast", "refseq_name": "Nto1p", "refseq_ac": "NP_015356", "gene_names_uniprotkb": "NTO1", "gene_names_refseq": "NTO1", "protein_names_uniprotkb": "NuA3 HAT complex component NTO1", "protein_names_refseq": "Nto1p", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YPR031W); (R-SCE-114608); (R-SCE-6804758)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "14562095;14562106;16412250;17157260;18407956;19779198;23749301;24374639;25104842;33481703;33491328;9169875", "class_list": "", "function": "Component of the NuA3 histone acetyltransferase complex. The NuA3 HAT complex has 2 functionally distinct forms. NuA3a binds H3K4me3, through the PHD finger of YNG1, and acetylates H3K14 at the promoter region of actively transcribed genes to promote transcription initiation. NuA3b binds H3K36me3 at the coding regions of actively transcribed genes, through the PWWP domain of PDP3, and coordinates transcription elongation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W441", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140566 histone reader activity;GO:0140003 histone H3K36me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990467 NuA3a histone acetyltransferase complex;GO:1990468 NuA3b histone acetyltransferase complex;GO:0033100 NuA3 histone acetyltransferase complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q12311-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12316-1", "uniprot_id": "YG13B_YEAST", "mass": 198560.0, "length": 1755, "protein_name": "Transposon Ty1-GR3 Gag-Pol polyprotein", "gene_name": "TY1B-GR3", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058165", "gene_names_uniprotkb": "TY1B-GR3; G7025; YGRCTy1-3 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-GR3 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR161C-D)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169869;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VUU4", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q12316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12317-1", "uniprot_id": "MSB4_YEAST", "mass": 57093.0, "length": 492, "protein_name": "GTPase-activating protein MSB4", "gene_name": "MSB4", "organism": "Yeast", "refseq_name": "Rab GTPase-activating protein MSB4", "refseq_ac": "NP_014529", "gene_names_uniprotkb": "MSB4; HRC492", "gene_names_refseq": "MSB4", "protein_names_uniprotkb": "GTPase-activating protein MSB4; Multicopy suppressor of bud emergence 4", "protein_names_refseq": "Rab GTPase-activating protein MSB4", "tax_id": 559292, "disease": "Ewing sarcoma (Disease Ontology:DOID:3369)", "pathway": " (sce:YOL112W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10679030;12913108;14562106;24374639;33491328;7502582;9169874", "class_list": "", "function": "Regulates exocytosis by functioning as a GAP for SEC4. Also required for efficient polarization of the actin patches., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1V5;Q05377;Q05378", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0000131 incipient cellular bud site;GO:0000133 polarisome;GO:0005934 cellular bud tip", "go_biological_process": "GO:0006887 exocytosis;GO:0006903 vesicle targeting;GO:0030010 establishment of cell polarity;GO:0030950 establishment or maintenance of actin cytoskeleton polarity;GO:0070649 formin-nucleated actin cable assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q12317-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12324-1", "uniprot_id": "YVC1_YEAST", "mass": 77953.0, "length": 675, "protein_name": "Calcium channel YVC1", "gene_name": "YVC1", "organism": "Yeast", "refseq_name": "Yvc1p", "refseq_ac": "NP_014730", "gene_names_uniprotkb": "YVC1; YOR088W; YOR3151W", "gene_names_refseq": "YOR088W; YVC1", "protein_names_uniprotkb": "Calcium channel YVC1; TRP homolog; Yeast vacuolar conductance protein 1", "protein_names_refseq": "Yvc1p", "tax_id": 559292, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); overactive bladder syndrome (Disease Ontology:DOID:0070355); Charcot-Marie-Tooth disease axonal type 2C (Disease Ontology:DOID:0110182); autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); autosomal dominant distal hereditary motor neuronopathy 8 (Disease Ontology:DOID:0111215); metatropic dysplasia (Disease Ontology:DOID:0111514); parastremmatic dwarfism (Disease Ontology:DOID:0111539); scapuloperoneal spinal muscular atrophy (Disease Ontology:DOID:0111552); spondyloepiphyseal dysplasia Maroteaux type (Disease Ontology:DOID:0111553); spondylometaphyseal dysplasia Kozlowski type (Disease Ontology:DOID:0111554); focal nonepidermolytic palmoplantar keratoderma 2 (Disease Ontology:DOID:0111711); autosomal dominant mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112013); migraine with aura (Disease Ontology:DOID:10024); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); gastric ulcer (Disease Ontology:DOID:10808); sciatic neuropathy (Disease Ontology:DOID:11446); gestational diabetes (Disease Ontology:DOID:11714); hyperparathyroidism (Disease Ontology:DOID:13543); reflex epilepsy (Disease Ontology:DOID:2548); dermatitis (Disease Ontology:DOID:2723); atopic dermatitis (Disease Ontology:DOID:3310); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); cocaine abuse (Disease Ontology:DOID:809); rosacea (Disease Ontology:DOID:8881); colorectal cancer (Disease Ontology:DOID:9256); diabetic neuropathy (Disease Ontology:DOID:9743); alopecia (Disease Ontology:DOID:987); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (sce:YOR087W); (R-SCE-3295583)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11427713;11781332;12748633;14562106;16847258;18407956;19779198;23749301;24374639;33481703;33491328;9169874;9200815", "class_list": "", "function": "Required for release of calcium ions from the vacuole in response to hyperosmotic shock., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2E9;Q08500;Q7LGN3", "ec_number_list": "", "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005267 potassium channel activity;GO:0005227 calcium-activated cation channel activity;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole;GO:1990816 vacuole-mitochondrion membrane contact site", "go_biological_process": "GO:0030003 intracellular monoatomic cation homeostasis;GO:0097553 calcium ion transmembrane import into cytosol;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12324-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12329-1", "uniprot_id": "HSP42_YEAST", "mass": 42817.0, "length": 375, "protein_name": "Heat shock protein 42", "gene_name": "HSP42", "organism": "Yeast", "refseq_name": "heat shock protein HSP42", "refseq_ac": "NP_010456", "gene_names_uniprotkb": "HSP42; YD9395.04", "gene_names_refseq": "HSP42", "protein_names_uniprotkb": "Heat shock protein 42; 42 kDa heat shock protein", "protein_names_refseq": "heat shock protein HSP42", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR171W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;15665377;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;21126336;21177495;23273919;23749301;24374639;27821475;30516470;32597660;33229814;33481703;33491328;8576246;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VSF3", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0042542 response to hydrogen peroxide;GO:0007010 cytoskeleton organization;GO:0006457 protein folding;GO:0009651 response to salt stress", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q12329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12333-1", "uniprot_id": "FRE7_YEAST", "mass": 70905.0, "length": 620, "protein_name": "Ferric/cupric reductase transmembrane component 7", "gene_name": "FRE7", "organism": "Yeast", "refseq_name": "putative ferric-chelate reductase", "refseq_ac": "NP_014489", "gene_names_uniprotkb": "FRE7; AOB629", "gene_names_refseq": "FRE7", "protein_names_uniprotkb": "Ferric/cupric reductase transmembrane component 7; 1.16.1.9; Ferric-chelate reductase 7", "protein_names_refseq": "putative ferric-chelate reductase", "tax_id": 559292, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); vascular dementia (Disease Ontology:DOID:8725); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (sce:YOL152W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10341420;17553781;17681937;18407956;24374639;33481703;8553699;9169874;9200812;9726978", "class_list": "", "function": "Cell surface metalloreductase. May be involved in copper homeostasis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1R8", "ec_number_list": "1.16.1.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0052851 ferric-chelate reductase (NADPH) activity;GO:0000293 ferric-chelate reductase activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0015677 copper ion import;GO:0006826 iron ion transport;GO:0033212 iron import into cell", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q12333-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12335-1", "uniprot_id": "PST2_YEAST", "mass": 20966.0, "length": 198, "protein_name": "Protoplast secreted protein 2", "gene_name": "PST2", "organism": "Yeast", "refseq_name": "flavodoxin-like fold family protein", "refseq_ac": "NP_010315", "gene_names_uniprotkb": "PST2; D3422; YD9673.02C", "gene_names_refseq": "PST2", "protein_names_uniprotkb": "Protoplast secreted protein 2", "protein_names_refseq": "flavodoxin-like fold family protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR032C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11079560;14562106;17322287;17330950;19779198;20702584;21126336;24374639;32597660;33481703;33491328;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS16", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0003955 NAD(P)H dehydrogenase (quinone) activity;GO:0010181 FMN binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0160020 positive regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q12335-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12338-1", "uniprot_id": "RNH2C_YEAST", "mass": 12482.0, "length": 110, "protein_name": "Ribonuclease H2 subunit C", "gene_name": "RNH203", "organism": "Yeast", "refseq_name": "Rnh203p", "refseq_ac": "NP_013255", "gene_names_uniprotkb": "RNH203", "gene_names_refseq": "RNH203", "protein_names_uniprotkb": "Ribonuclease H2 subunit C; RNase H(203); RNase H2 subunit C; Ribonuclease HI subunit C; Rnh2C", "protein_names_refseq": "Rnh203p", "tax_id": 559292, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (sce:YLR154C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;14734815;17322287;23749301;24374639;33491328;7649171;9169871", "class_list": "", "function": "Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYE9;Q6Q5B9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q12338-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12339-1", "uniprot_id": "UTP23_YEAST", "mass": 28801.0, "length": 254, "protein_name": "rRNA-processing protein UTP23", "gene_name": "UTP23", "organism": "Yeast", "refseq_name": "rRNA-binding ribosome biosynthesis protein UTP23", "refseq_ac": "NP_014646", "gene_names_uniprotkb": "UTP23", "gene_names_refseq": "UTP23", "protein_names_uniprotkb": "rRNA-processing protein UTP23; U three protein 23; U3 small nucleolar RNA-associated protein 23; U3 snoRNA-associated protein 23", "protein_names_refseq": "rRNA-binding ribosome biosynthesis protein UTP23", "tax_id": 559292, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (sce:YOR004W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12089522;14562095;14562106;14690591;18407956;19779198;23749301;24374639;30516470;32597660;33481703;33491328;8896276;9169874", "class_list": "", "function": "Involved in rRNA-processing and ribosome biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W270", "ec_number_list": "", "go_molecular_function": "GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q12339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12349-1", "uniprot_id": "ATP14_YEAST", "mass": 14128.0, "length": 124, "protein_name": "ATP synthase subunit H, mitochondrial", "gene_name": "ATP14", "organism": "Yeast", "refseq_name": "F1F0 ATP synthase subunit h", "refseq_ac": "NP_013398", "gene_names_uniprotkb": "ATP14; L8003.20", "gene_names_refseq": "ATP14", "protein_names_uniprotkb": "ATP synthase subunit H, mitochondrial", "protein_names_refseq": "F1F0 ATP synthase subunit h", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR295C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;17322287;24374639;33481703;8702761;9169871", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYU0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042407 cristae formation;GO:0015986 proton motive force-driven ATP synthesis;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12349-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12355-1", "uniprot_id": "PST1_YEAST", "mass": 45777.0, "length": 444, "protein_name": "Cell wall mannoprotein PST1", "gene_name": "PST1", "organism": "Yeast", "refseq_name": "Pst1p", "refseq_ac": "NP_010340", "gene_names_uniprotkb": "PST1; D4214; HPF2; YD9609.09", "gene_names_refseq": "HPF2; PST1", "protein_names_uniprotkb": "Cell wall mannoprotein PST1; Haze protective factor 2; Protoplast secreted protein 1", "protein_names_refseq": "Pst1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR055W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10234784;10383953;10594829;11016834;14562106;15116342;15583168;17024473;24374639;24909858;33491328;8789263;9169867", "class_list": "", "function": "Has a partially redundant function to ECM33 in cell wall integrity. May be involved in a repair mechanism activated in response to cell wall damage., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "D6VS41", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0000324 fungal-type vacuole;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q12355-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12361-1", "uniprot_id": "GPR1_YEAST", "mass": 110709.0, "length": 961, "protein_name": "G protein-coupled receptor GPR1", "gene_name": "GPR1", "organism": "Yeast", "refseq_name": "Gpr1p", "refseq_ac": "NP_010249", "gene_names_uniprotkb": "GPR1", "gene_names_refseq": "GPR1", "protein_names_uniprotkb": "G protein-coupled receptor GPR1", "protein_names_refseq": "Gpr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL035C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "16847258;17330950;17563356;18407956;19779198;19795423;19823750;21126336;23749301;24374639;32597660;33481703;33491328;9046088;9169867;9524122", "class_list": "", "function": "Seems to associate with GPA2 and act as G protein-coupled receptor that senses glucose and controls filamentous growth. It acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VRV9", "ec_number_list": "", "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010255 glucose mediated signaling pathway;GO:0009731 detection of sucrose stimulus;GO:0001403 invasive growth in response to glucose limitation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q12361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12362-1", "uniprot_id": "RIB2_YEAST", "mass": 67036.0, "length": 591, "protein_name": "Bifunctional protein RIB2", "gene_name": "RIB2", "organism": "Yeast", "refseq_name": "bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2", "refseq_ac": "NP_014575", "gene_names_uniprotkb": "RIB2; PUS8", "gene_names_refseq": "PUS8; RIB2", "protein_names_uniprotkb": "Bifunctional protein RIB2; Riboflavin-specific deaminase; tRNA pseudouridine synthase 8; tRNA pseudouridylate synthase 8; tRNA-uridine isomerase 8", "protein_names_refseq": "bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL066C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11947306;14562106;15466869;24374639;33491328;4555411;9169874;9178509", "class_list": "", "function": "Involved in riboflavin biosynthesis. Converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate., [UniProtKB, PubMed]; Responsible for synthesis of pseudouridine from uracil-32 in cytoplasmic transfer RNAs., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W201", "ec_number_list": "5.4.99.28;3.5.4.26", "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0009982 pseudouridine synthase activity;GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity;GO:0160151 tRNA pseudouridine(32) synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0009231 riboflavin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12362-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12372-1", "uniprot_id": "MMP1_YEAST", "mass": 64218.0, "length": 583, "protein_name": "S-methylmethionine permease 1", "gene_name": "MMP1", "organism": "Yeast", "refseq_name": "S-methylmethionine permease MMP1", "refseq_ac": "NP_013039", "gene_names_uniprotkb": "MMP1; L0555", "gene_names_refseq": "MMP1", "protein_names_uniprotkb": "S-methylmethionine permease 1", "protein_names_refseq": "S-methylmethionine permease MMP1", "tax_id": 559292, "disease": "retinitis pigmentosa 68 (Disease Ontology:DOID:0110374)", "pathway": " (sce:YLL061W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10497160;14562095;16847258;19684113;19779198;19795423;19823750;20702584;21177495;24374639;32597660;33229814;33481703;33491328;9169871", "class_list": "", "function": "High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VXU8", "ec_number_list": "", "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0000100 S-methylmethionine transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0003333 amino acid transmembrane transport;GO:0015806 S-methylmethionine transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q12372-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12377-1", "uniprot_id": "RPN6_YEAST", "mass": 49774.0, "length": 434, "protein_name": "26S proteasome regulatory subunit RPN6", "gene_name": "RPN6", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit RPN6", "refseq_ac": "NP_010186", "gene_names_uniprotkb": "RPN6; D2381; NAS4", "gene_names_refseq": "NAS4; RPN6", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN6; Proteasome non-ATPase subunit 4", "protein_names_refseq": "proteasome regulatory particle lid subunit RPN6", "tax_id": 559292, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (sce:YDL097C); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "12486135;12504901;14562106;15611133;17563356;20486117;22814378;22927375;24374639;33481703;33491328;8923743;9169867;9426256", "class_list": "", "function": "Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRQ3", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q12377-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12382-1", "uniprot_id": "DGK1_YEAST", "mass": 32840.0, "length": 290, "protein_name": "CTP-dependent diacylglycerol kinase 1", "gene_name": "DGK1", "organism": "Yeast", "refseq_name": "diacylglycerol kinase", "refseq_ac": "NP_014956", "gene_names_uniprotkb": "DGK1; HSD1; O6111", "gene_names_refseq": "DGK1; HSD1", "protein_names_uniprotkb": "CTP-dependent diacylglycerol kinase 1; 2.7.1.174; DAG kinase 1; Diglyceride kinase 1; High-copy suppressor of SLY1 defect protein 1", "protein_names_refseq": "diacylglycerol kinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR311C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10407277;11481671;14562095;14562106;16847258;17330950;18458075;18458076;19684113;19779198;19795423;19823750;21071438;21126336;23749301;24374639;27834677;33481703;33491328;8896266;9169874", "class_list": "", "function": "CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. Counteracts the activity of PA phosphatase PAH1/SMP2, controlling the levels of PA and DAG for the synthesis of triacylglycerol and membrane phospholipids (PubMed:18458075, PubMed:27834677). May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus (PubMed:11481671). Required to convert triacylglycerol-derived DAG to PA for phospholipid synthesis during growth resumption from stationary phase in the absence of de novo fatty acid synthesis (PubMed:21071438). Involved in the resistance to nickel chloride and nalidixic acid (PubMed:10407277)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W310", "ec_number_list": "2.7.1.174", "go_molecular_function": "GO:0001727 lipid kinase activity;GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0141035 CTP-dependent diacylglycerol kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0016192 vesicle-mediated transport;GO:2001210 regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q12382-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12386-1", "uniprot_id": "ARP8_YEAST", "mass": 100209.0, "length": 881, "protein_name": "Actin-like protein ARP8", "gene_name": "ARP8", "organism": "Yeast", "refseq_name": "Arp8p", "refseq_ac": "NP_014784", "gene_names_uniprotkb": "ARP8; YOR3348C", "gene_names_refseq": "ARP8", "protein_names_uniprotkb": "Actin-like protein ARP8", "protein_names_refseq": "Arp8p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR141C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12887900;14562106;17330950;18407956;19779198;20702584;23213201;23749301;24374639;32597660;33481703;33491328;9169874;9200815;9290209", "class_list": "", "function": "Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Exhibits low basal ATPase activity, and unable to polymerize. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2J7", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0031011 Ino80 complex", "go_biological_process": "GO:0006312 mitotic recombination;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q12386-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12395-1", "uniprot_id": "DCN1_YEAST", "mass": 32204.0, "length": 269, "protein_name": "Defective in cullin neddylation protein 1", "gene_name": "DCN1", "organism": "Yeast", "refseq_name": "NEDD8 ligase DCN1", "refseq_ac": "NP_013229", "gene_names_uniprotkb": "DCN1; L3111", "gene_names_refseq": "DCN1", "protein_names_uniprotkb": "Defective in cullin neddylation protein 1", "protein_names_refseq": "NEDD8 ligase DCN1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR128W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11283612;15988528;17563356;18407956;19779198;21940857;24374639;30516470;32597660;33481703;33491328;9090053;9169871", "class_list": "", "function": "Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with HRT1/RBX1 to recruit the Nedd8-charged E2 UBC12 to the cullin component of SCF-type complexes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYC3", "ec_number_list": "", "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0030674 protein-macromolecule adaptor activity;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12395-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12400-1", "uniprot_id": "TRM10_YEAST", "mass": 34520.0, "length": 293, "protein_name": "tRNA (guanine(9)-N1)-methyltransferase", "gene_name": "TRM10", "organism": "Yeast", "refseq_name": "tRNA (guanine(9)-N(1))-methyltransferase", "refseq_ac": "NP_014548", "gene_names_uniprotkb": "TRM10; O0926", "gene_names_refseq": "TRM10", "protein_names_uniprotkb": "tRNA (guanine(9)-N1)-methyltransferase; 2.1.1.221; tRNA methyltransferase 10; tRNA(m1G9)-methyltransferase; tRNA(m1G9)MTase", "protein_names_refseq": "tRNA (guanine(9)-N(1))-methyltransferase", "tax_id": 559292, "disease": "intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907); glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (sce:YOL093W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12702816;14562095;14562106;15640439;18407956;19779198;20702584;21126336;22218487;22814378;23793893;24081582;24374639;32597660;33481703;33491328;8533473;9169874", "class_list": "", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1X5", "ec_number_list": "2.1.1.221", "go_molecular_function": "GO:0016423 tRNA (guanine) methyltransferase activity;GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0002939 tRNA N1-guanine methylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q12400-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12402-1", "uniprot_id": "YOP1_YEAST", "mass": 20270.0, "length": 180, "protein_name": "Protein YOP1", "gene_name": "YOP1", "organism": "Yeast", "refseq_name": "Yop1p", "refseq_ac": "NP_015353", "gene_names_uniprotkb": "YOP1; YIP2; YP9367.08", "gene_names_refseq": "YIP2; YOP1", "protein_names_uniprotkb": "Protein YOP1; YIP1 partner protein 1; YPT-interacting protein 2", "protein_names_refseq": "Yop1p", "tax_id": 559292, "disease": "retinitis pigmentosa 77 (Disease Ontology:DOID:0080350); hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (sce:YPR028W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11278413;12427979;14562095;14562106;18442980;19795423;19823750;21126336;22814378;23749301;24374639;24909858;25646439;30516470;32432369;33491328;9169875", "class_list": "", "function": "Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole (PubMed:25646439, PubMed:32432369). Induces high curvature in membranes and causes membrane tubule formation (Probable). Involved in membrane/vesicle trafficking (PubMed:12427979)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W438", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0016192 vesicle-mediated transport;GO:0034976 response to endoplasmic reticulum stress;GO:0007033 vacuole organization;GO:0032581 ER-dependent peroxisome organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q12402-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12404-1", "uniprot_id": "MPD1_YEAST", "mass": 36408.0, "length": 318, "protein_name": "Protein disulfide-isomerase MPD1", "gene_name": "MPD1", "organism": "Yeast", "refseq_name": "protein disulfide isomerase MPD1", "refseq_ac": "NP_014931", "gene_names_uniprotkb": "MPD1", "gene_names_refseq": "MPD1", "protein_names_uniprotkb": "Protein disulfide-isomerase MPD1; 5.3.4.1", "protein_names_refseq": "protein disulfide isomerase MPD1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR288C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;16002399;24374639;7649260;8896271;9169874", "class_list": "", "function": "Participates in the folding of proteins containing disulfide bonds., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Y6", "ec_number_list": "", "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12404-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12406-1", "uniprot_id": "ARP7_YEAST", "mass": 53810.0, "length": 477, "protein_name": "Actin-related protein 7", "gene_name": "ARP7", "organism": "Yeast", "refseq_name": "Arp7p", "refseq_ac": "NP_015359", "gene_names_uniprotkb": "ARP7; SWP61; YP9367.14", "gene_names_refseq": "ARP7; RSC11; SWP61", "protein_names_uniprotkb": "Actin-related protein 7; Actin-like protein ARP7; Chromatin structure-remodeling complex protein ARP7; SWI/SNF complex component ARP7", "protein_names_refseq": "Arp7p", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 76 (Disease Ontology:DOID:0112212); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (sce:YPR034W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10025404;10329629;10619019;12072455;12183366;12524530;12697820;12805231;14562106;16204215;20190278;23749301;24374639;33491328;8980231;9169875;9290209;9844636", "class_list": "", "function": "Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in transcriptional regulation. Heterodimer of ARP7 and ARP9 functions with HMG box proteins to facilitate proper chromatin architecture. Heterodimer formation is necessary for assembly into RSC complex. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W444", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q12406-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12414-1", "uniprot_id": "YP11B_YEAST", "mass": 198576.0, "length": 1755, "protein_name": "Transposon Ty1-PL Gag-Pol polyprotein", "gene_name": "TY1B-PL", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058189", "gene_names_uniprotkb": "TY1B-PL; P0729; YPLWTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-PL Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL257W-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169875;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W3B2", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q12414-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12416-1", "uniprot_id": "WHI5_YEAST", "mass": 32901.0, "length": 295, "protein_name": "G1-specific transcriptional repressor WHI5", "gene_name": "WHI5", "organism": "Yeast", "refseq_name": "transcriptional repressor WHI5", "refseq_ac": "NP_014726", "gene_names_uniprotkb": "WHI5; YOR3116W", "gene_names_refseq": "WHI5", "protein_names_uniprotkb": "G1-specific transcriptional repressor WHI5", "protein_names_refseq": "transcriptional repressor WHI5", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR083W)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "14562095;14562106;14574415;15210110;15210111;15665377;16912276;17287358;17322287;17563356;18407956;19172996;19520826;19684113;19713766;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;25733686;30516470;32597660;33481703;33491328;9169874;9200815", "class_list": "", "function": "Transcriptional repressor that negatively regulates G1-specific, SBF- and MBF-dependent transcription. Binds via SBF to promoters of G1-specific genes to repress transcription in early G1. During G1, phosphorylated by cyclin-CDK CLN3-CDC28 and progressively hyperphosphorylated by CDK associated with other G1-cyclins, which leads to dissociation of WHI5 from SBF, activating SBF-dependent transcription in late G1. Elimination of CDK activity at the end of mitosis by the mitotic exit network (MEN) allows WHI5 to reassociate with SBF to again repress G1/S transcription., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 43, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2E5", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0033309 SBF transcription complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010508 positive regulation of autophagy;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q12416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12429-1", "uniprot_id": "DPH6_YEAST", "mass": 77941.0, "length": 685, "protein_name": "Diphthine--ammonia ligase", "gene_name": "DPH6", "organism": "Yeast", "refseq_name": "diphthine--ammonia ligase", "refseq_ac": "NP_013244", "gene_names_uniprotkb": "DPH6; L3177", "gene_names_refseq": "DPH6", "protein_names_uniprotkb": "Diphthine--ammonia ligase; 6.3.1.14; Diphthamide synthase; Diphthamide synthetase", "protein_names_refseq": "diphthine--ammonia ligase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR143W); (R-SCE-5358493)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562095;14562106;19795423;19823750;23169644;23468660;23645155;24374639;33481703;33491328;9169871", "class_list": "", "function": "Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EFT1 or EFT2) to diphthamide., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYD7;Q07261", "ec_number_list": "3.6.5.-;6.3.1.14", "go_molecular_function": "GO:0017178 diphthine-ammonia ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12429-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12438-1", "uniprot_id": "GLRX6_YEAST", "mass": 25783.0, "length": 231, "protein_name": "Monothiol glutaredoxin-6", "gene_name": "GRX6", "organism": "Yeast", "refseq_name": "glutathione-disulfide reductase GRX6", "refseq_ac": "NP_010274", "gene_names_uniprotkb": "GRX6; D2890", "gene_names_refseq": "GRX6", "protein_names_uniprotkb": "Monothiol glutaredoxin-6", "protein_names_refseq": "glutathione-disulfide reductase GRX6", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL010W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;19684113;22814378;24374639;9169867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRX8", "ec_number_list": "", "go_molecular_function": "GO:0015038 glutathione disulfide oxidoreductase activity;GO:0005506 iron ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0004362 glutathione-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12443-1", "uniprot_id": "RTN2_YEAST", "mass": 44359.0, "length": 393, "protein_name": "Reticulon-like protein 2", "gene_name": "RTN2", "organism": "Yeast", "refseq_name": "Rtn2p", "refseq_ac": "NP_010077", "gene_names_uniprotkb": "RTN2; D1062", "gene_names_refseq": "RTN2", "protein_names_uniprotkb": "Reticulon-like protein 2", "protein_names_refseq": "Rtn2p", "tax_id": 559292, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (sce:YDL204W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12832288;14562095;16847258;18407956;19684113;24374639;33229814;33491328;9046097;9169867", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VRF0", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0034976 response to endoplasmic reticulum stress;GO:0032581 ER-dependent peroxisome organization;GO:0071788 endoplasmic reticulum tubular network maintenance;GO:0048309 endoplasmic reticulum inheritance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12443-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12445-1", "uniprot_id": "POM34_YEAST", "mass": 34232.0, "length": 299, "protein_name": "Nucleoporin POM34", "gene_name": "POM34", "organism": "Yeast", "refseq_name": "Pom34p", "refseq_ac": "NP_013118", "gene_names_uniprotkb": "POM34", "gene_names_refseq": "POM34", "protein_names_uniprotkb": "Nucleoporin POM34; Nuclear pore protein POM34; Pore membrane protein POM34", "protein_names_refseq": "Pom34p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR018C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10684247;11875433;12791264;15665377;17287358;17322287;17330950;18407956;19684113;19779198;19795423;19823750;20702584;22218487;23749301;24374639;30516470;32597660;33481703;33491328;9169871", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY20;E9P8U3;Q7LGY6", "ec_number_list": "", "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0034399 nuclear periphery;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006606 protein import into nucleus;GO:0030474 spindle pole body duplication", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q12445-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12457-1", "uniprot_id": "NSI1_YEAST", "mass": 66352.0, "length": 570, "protein_name": "RNA polymerase I termination factor", "gene_name": "NSI1", "organism": "Yeast", "refseq_name": "Nsi1p", "refseq_ac": "NP_010309", "gene_names_uniprotkb": "NSI1; PZE570", "gene_names_refseq": "NSI1; YTT1", "protein_names_uniprotkb": "RNA polymerase I termination factor; NTS1 silencing protein 1", "protein_names_refseq": "Nsi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR026C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;14576157;19779198;22362748;22805593;23749301;24374639;33481703;33491328;8896275;9169867", "class_list": "", "function": "DNA-binding protein that recognizes sequence-specific replication termini (Ter sites) within rDNA (PubMed:14576157). Binds to rDNA terminator elements and mediates efficient RNA polymerase I transcription termination (PubMed:22805593). Required for rDNA silencing at the non-transcribed spacer 1 (NTS1). Promotes the association of SIR2 with NTS1 and contributes to maintenance of rDNA stability (PubMed:22362748)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS11", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0033553 rDNA heterochromatin", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0000183 rDNA heterochromatin formation;GO:0006363 termination of RNA polymerase I transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q12457-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12462-1", "uniprot_id": "PEX11_YEAST", "mass": 26875.0, "length": 236, "protein_name": "Peroxisomal membrane protein PMP27", "gene_name": "PEX11", "organism": "Yeast", "refseq_name": "Pex11p", "refseq_ac": "NP_014494", "gene_names_uniprotkb": "PEX11; O0454; PMP24; PMP27", "gene_names_refseq": "PEX11; PMP24; PMP27", "protein_names_uniprotkb": "Peroxisomal membrane protein PMP27; Peroxin-11", "protein_names_refseq": "Pex11p", "tax_id": 559292, "disease": "peroxisome biogenesis disorder 14B (Disease Ontology:DOID:0081274); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (sce:YOL147C); (R-SCE-9603798)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14517321;14517338;14562095;14562106;17322287;21441307;22814378;24374639;33491328;7721939;7860627;8553699;9169874", "class_list": "", "function": "Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1S2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0007165 signal transduction;GO:0016559 peroxisome fission;GO:0007031 peroxisome organization;GO:0044375 regulation of peroxisome size;GO:0001579 medium-chain fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12462-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12463-1", "uniprot_id": "TRM11_YEAST", "mass": 50073.0, "length": 433, "protein_name": "tRNA (guanine(10)-N(2))-methyltransferase", "gene_name": "TRM11", "organism": "Yeast", "refseq_name": "tRNA (guanine-N2-)-methyltransferase", "refseq_ac": "NP_014517", "gene_names_uniprotkb": "TRM11", "gene_names_refseq": "TRM11", "protein_names_uniprotkb": "tRNA (guanine(10)-N(2))-methyltransferase; 2.1.1.214; tRNA [Gm10] methyltransferase; tRNA guanosine-2'-O-methyltransferase TRM11; tRNA methylase 11", "protein_names_refseq": "tRNA (guanine-N2-)-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL124C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562095;14562106;15899842;24374639;8896265;9169874", "class_list": "", "function": "Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1U4", "ec_number_list": "2.1.1.214", "go_molecular_function": "GO:0000049 tRNA binding;GO:0008168 methyltransferase activity;GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043528 tRNA (m2G10) methyltransferase complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12463-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12465-1", "uniprot_id": "RAX2_YEAST", "mass": 133959.0, "length": 1220, "protein_name": "Bud site selection protein RAX2", "gene_name": "RAX2", "organism": "Yeast", "refseq_name": "Rax2p", "refseq_ac": "NP_013185", "gene_names_uniprotkb": "RAX2; L2389; L9449.12", "gene_names_refseq": "RAX2", "protein_names_uniprotkb": "Bud site selection protein RAX2; Revert to axial protein 2", "protein_names_refseq": "Rax2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR084C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11110666;14562095;14562106;15356260;20678480;21625000;24374639;32152126;33491328;9169871", "class_list": "", "function": "Required for the maintenance of the bipolar budding pattern (PubMed:11110666). Involved in selecting bud sites at both the distal and proximal poles of daughter cells as well as near previously used division sites on mother cells (PubMed:11110666). The RAX1-RAX2 complex performs the asymmetric localization of the two cortical landmarks, BUD8 and BUD9, at the distal and proximal poles, respectively (PubMed:20678480, PubMed:32152126)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 52, "predicted_n_glycosites": 52, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 52, "binding_glycan_count": 0, "secondary_ac_list": "D6VY84", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:1902929 plasma membrane of growing cell tip;GO:0005621 cellular bud scar;GO:0005934 cellular bud tip", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0000282 cellular bud site selection;GO:0007120 axial cellular bud site selection;GO:0007121 bipolar cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q12465-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12468-1", "uniprot_id": "CSN5_YEAST", "mass": 50812.0, "length": 440, "protein_name": "COP9 signalosome complex subunit 5", "gene_name": "RRI1", "organism": "Yeast", "refseq_name": "COP9 signalosome catalytic subunit RRI1", "refseq_ac": "NP_010065", "gene_names_uniprotkb": "RRI1; CSN5; D0888; JAB1", "gene_names_refseq": "CSN5; JAB1; RRI1", "protein_names_uniprotkb": "COP9 signalosome complex subunit 5; 3.4.-.-", "protein_names_refseq": "COP9 signalosome catalytic subunit RRI1", "tax_id": 559292, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YDL216C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11805826;12183637;12186635;12446563;12672462;12748633;12775844;14562095;18407956;24374639;33491328;9046097;9169867", "class_list": "", "function": "Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the mating pheromone response., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRD8", "ec_number_list": "", "go_molecular_function": "GO:0019784 deNEDDylase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0006508 proteolysis;GO:0000338 protein deneddylation;GO:0051726 regulation of cell cycle;GO:0071444 cellular response to pheromone;GO:2000434 regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q12468-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12469-1", "uniprot_id": "SKM1_YEAST", "mass": 75331.0, "length": 655, "protein_name": "Serine/threonine-protein kinase SKM1", "gene_name": "SKM1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase SKM1", "refseq_ac": "NP_014528", "gene_names_uniprotkb": "SKM1; HRA655", "gene_names_refseq": "SKM1", "protein_names_uniprotkb": "Serine/threonine-protein kinase SKM1; 2.7.11.1; Protein kinase 75490 D", "protein_names_refseq": "putative serine/threonine protein kinase SKM1", "tax_id": 559292, "disease": "stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); ductal carcinoma in situ (Disease Ontology:DOID:0060074); non-syndromic X-linked intellectual disability 30 (Disease Ontology:DOID:0112051); Alzheimer's disease (Disease Ontology:DOID:10652); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YOL113W); (R-SCE-2029482); (R-SCE-389359); (R-SCE-3928662); (R-SCE-445144); (R-SCE-5627123); (R-SCE-5687128); (R-SCE-9013406); (R-SCE-9013420); (R-SCE-9013424)", "pathway_count": 10, "publication_count": 12, "publication_id_list": "14562106;17322287;20489023;21126336;23749301;24374639;32597660;33481703;33491328;7502582;9044278;9169874", "class_list": "", "function": "May be involved in cellular signaling or cytoskeletal functions. May play a role in morphogenetic control., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1V4;E9P934;Q06940", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;3.6.5.2;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;2.3.2.26;3.4.-.-;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0035556 intracellular signal transduction;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q12469-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12473-1", "uniprot_id": "FRE6_YEAST", "mass": 81989.0, "length": 712, "protein_name": "Ferric reductase transmembrane component 6", "gene_name": "FRE6", "organism": "Yeast", "refseq_name": "putative ferric-chelate reductase", "refseq_ac": "NP_013049", "gene_names_uniprotkb": "FRE6; L0593", "gene_names_refseq": "FRE6", "protein_names_uniprotkb": "Ferric reductase transmembrane component 6; 1.16.1.9; Ferric-chelate reductase 6", "protein_names_refseq": "putative ferric-chelate reductase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLL051C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10341420;14562095;16024809;16847258;17553781;17681937;21126336;24374639;9169871;9726978", "class_list": "", "function": "Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VXV7", "ec_number_list": "1.16.1.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0052851 ferric-chelate reductase (NADPH) activity;GO:0000293 ferric-chelate reductase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0015677 copper ion import;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q12473-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12482-1", "uniprot_id": "AGC1_YEAST", "mass": 104304.0, "length": 902, "protein_name": "Mitochondrial aspartate-glutamate transporter AGC1", "gene_name": "AGC1", "organism": "Yeast", "refseq_name": "citrin", "refseq_ac": "NP_015346", "gene_names_uniprotkb": "AGC1; YP9367.01C", "gene_names_refseq": "AGC1", "protein_names_uniprotkb": "Mitochondrial aspartate-glutamate transporter AGC1; Aspartate-glutamate carrier 1", "protein_names_refseq": "citrin", "tax_id": 559292, "disease": "Asperger syndrome (Disease Ontology:DOID:0050432); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); autism spectrum disorder (Disease Ontology:DOID:0060041); neonatal-onset type II citrullinemia (Disease Ontology:DOID:0070341); adult-onset type II citrullinemia (Disease Ontology:DOID:0070342); developmental and epileptic encephalopathy 39 (Disease Ontology:DOID:0080349); autistic disorder (Disease Ontology:DOID:12849); intrahepatic cholestasis (Disease Ontology:DOID:1852); common bile duct disease (Disease Ontology:DOID:4137); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (sce:YPR021C); (R-SCE-442660); (R-SCE-8963693); (R-SCE-9856872)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "14576278;14622413;19779198;19795423;19823750;24374639;9169875;9178508", "class_list": "", "function": "Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W431", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0015292 uniporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1990816 vacuole-mitochondrion membrane contact site", "go_biological_process": "GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12482-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12490-1", "uniprot_id": "YB11B_YEAST", "mass": 198969.0, "length": 1755, "protein_name": "Transposon Ty1-BL Gag-Pol polyprotein", "gene_name": "TY1B-BL", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_009549", "gene_names_uniprotkb": "TY1B-BL; YBL004W-A; YBL0325; YBLWTy1-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-BL Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL005W-B)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "16093660;16093680;17330950;17563356;18407956;19779198;21177495;24374639;7813418;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VPZ6", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q12490-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12491-1", "uniprot_id": "YB21B_YEAST", "mass": 202215.0, "length": 1770, "protein_name": "Transposon Ty2-B Gag-Pol polyprotein", "gene_name": "TY2B-B", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_009450", "gene_names_uniprotkb": "TY2B-B; YBL0822; YBL101W-B; YBLWTy2-1 POL", "gene_names_refseq": "YBL101W-B", "protein_names_uniprotkb": "Transposon Ty2-B Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL100W-B)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;17330950;24374639;7502586;7813418;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPQ4;Q05679", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12491-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12494-1", "uniprot_id": "KCS1_YEAST", "mass": 119550.0, "length": 1050, "protein_name": "Inositol hexakisphosphate kinase 1", "gene_name": "KCS1", "organism": "Yeast", "refseq_name": "inositol polyphosphate kinase KCS1", "refseq_ac": "NP_010300", "gene_names_uniprotkb": "KCS1; PZF1050", "gene_names_refseq": "KCS1", "protein_names_uniprotkb": "Inositol hexakisphosphate kinase 1; 2.7.4.21; InsP6 kinase 1; InsP6 kinase KCS1; PKC1 suppressor protein 1", "protein_names_refseq": "inositol polyphosphate kinase KCS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR017C); (R-SCE-1855167); (R-SCE-1855191)", "pathway_count": 3, "publication_count": 32, "publication_id_list": "10574768;10827188;11956213;14562095;14562106;15561716;15665377;15866881;15944147;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;35640071;8601473;8896275;9169867", "class_list": "", "function": "Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 59, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VS03;P89899;Q7LGR2", "ec_number_list": "2.7.1.127;2.7.1.151;2.7.4.21", "go_molecular_function": "GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity;GO:0000828 inositol hexakisphosphate kinase activity;GO:0000829 diphosphoinositol pentakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0030643 intracellular phosphate ion homeostasis;GO:0032958 inositol phosphate biosynthetic process;GO:0010919 regulation of inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "Q12494-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12501-1", "uniprot_id": "YO22B_YEAST", "mass": 202131.0, "length": 1770, "protein_name": "Transposon Ty2-OR2 Gag-Pol polyprotein", "gene_name": "TY2B-OR2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_620389", "gene_names_uniprotkb": "TY2B-OR2; O6304; YORWTy2-2 POL", "gene_names_refseq": "YOR343C-B", "protein_names_uniprotkb": "Transposon Ty2-OR2 Gag-Pol polyprotein; TY2A-TY2B; Transposon Ty2 TYA-TYB polyprotein", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR343W-B)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16093660;17330950;24374639;33229814;9169874;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W338", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q12501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12505-1", "uniprot_id": "SKS1_YEAST", "mass": 57844.0, "length": 502, "protein_name": "Serine/threonine-protein kinase SKS1", "gene_name": "SKS1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase SKS1", "refseq_ac": "NP_015299", "gene_names_uniprotkb": "SKS1; LPB5; SHA3", "gene_names_refseq": "SHA3; SKS1", "protein_names_uniprotkb": "Serine/threonine-protein kinase SKS1; 2.7.11.1; Suppressor kinase of SNF3", "protein_names_refseq": "putative serine/threonine protein kinase SKS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL026C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;22814378;24374639;33491328;8948096;9169875", "class_list": "", "function": "May have a role in glucose regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3Y7", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle;GO:0010827 regulation of D-glucose transmembrane transport;GO:0007124 pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q12505-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12509-1", "uniprot_id": "ARP6_YEAST", "mass": 50044.0, "length": 438, "protein_name": "Actin-like protein ARP6", "gene_name": "ARP6", "organism": "Yeast", "refseq_name": "Arp6p", "refseq_ac": "NP_013186", "gene_names_uniprotkb": "ARP6; L2393; L9449.13", "gene_names_refseq": "ARP6", "protein_names_uniprotkb": "Actin-like protein ARP6", "protein_names_refseq": "Arp6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR085C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;14645854;14690608;15045029;24374639;33491328;9169871;9290209", "class_list": "", "function": "Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VY85", "ec_number_list": "", "go_molecular_function": "GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000812 Swr1 complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q12509-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12511-1", "uniprot_id": "PDP1_YEAST", "mass": 63669.0, "length": 572, "protein_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "gene_name": "PTC5", "organism": "Yeast", "refseq_name": "type 2C protein phosphatase PTC5", "refseq_ac": "NP_014733", "gene_names_uniprotkb": "PTC5; PPP1; YOR3157C", "gene_names_refseq": "PPP1; PTC5", "protein_names_uniprotkb": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; 3.1.3.43; PDC phosphatase 1; PDP 1; PP2C-5; Phosphatase two C protein 5; Protein phosphatase 2C homolog 5; Protein phosphatase of PDH protein 1; Pyruvate dehydrogenase complex phosphatase 1", "protein_names_refseq": "type 2C protein phosphatase PTC5", "tax_id": 559292, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YOR090C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;14576278;16643908;18180296;22984289;23749301;24374639;33491328;9169874;9200815", "class_list": "", "function": "Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2F1", "ec_number_list": "3.1.3.16;3.1.3.43", "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005777 peroxisome", "go_biological_process": "GO:0070262 peptidyl-serine dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q12511-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12524-1", "uniprot_id": "PCD1_YEAST", "mass": 39755.0, "length": 340, "protein_name": "Peroxisomal coenzyme A diphosphatase 1, peroxisomal", "gene_name": "PCD1", "organism": "Yeast", "refseq_name": "8-oxo-dGTP diphosphatase", "refseq_ac": "NP_013252", "gene_names_uniprotkb": "PCD1; L9634.8", "gene_names_refseq": "PCD1", "protein_names_uniprotkb": "Peroxisomal coenzyme A diphosphatase 1, peroxisomal; 3.6.1.-; 3.6.1.56; 3.6.1.77; 8-oxo-dGTP/2-hydroxy-dATP diphosphatase; Pcd1p", "protein_names_refseq": "8-oxo-dGTP diphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR151C); (R-SCE-9033241)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10922370;14562106;15475388;17322287;24374639;33491328;9169871", "class_list": "", "function": "Diphosphatase (pyrophosphatase) with specificity for coenzyme A and CoA derivatives. Catalyzes the hydrolysis of the diphosphate linkage in CoA to give 3',5'-ADP and 4'-phosphopantetheine. Prefers oxidized CoA disulfide (CoASSCoA) over CoA as a substrate. May be required to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids (PubMed:10922370). Can also hydrolyze 8-oxo-dGTP and 2-OH-dATP in vitro; therefore it may function as a sanitizing enzyme for oxidized nucleotides and may contribute to prevention of spontaneous mutagenesis due to the misincorporation of these oxidized nucleotides during DNA synthesis (PubMed:15475388). Shows moderate activity in vitro with several short chain acyl-CoA esters and very low activity on 3'-dephospho-CoA while is not active with (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di- or monophosphates, diadenosine polyphosphates, nucleoside 5'-diphosphosugars, cytidine 5'-diphosphoalcohols, NAD(+), NADH, or FAD (PubMed:10922370)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYE6", "ec_number_list": "1.11.1.6;1.6.2.4;1.1.1.42;1.3.1.124;2.3.1.7;4.1.2.63;3.1.2.2;2.3.2.27;5.3.3.8;3.4.24.-;3.6.1.-;3.6.1.56;3.6.1.77", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0008828 dATP diphosphatase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0009132 nucleoside diphosphate metabolic process;GO:0015938 coenzyme A catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q12524-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12530-1", "uniprot_id": "RMP1_YEAST", "mass": 23619.0, "length": 201, "protein_name": "Ribonuclease MRP protein subunit RMP1", "gene_name": "RMP1", "organism": "Yeast", "refseq_name": "Rmp1p", "refseq_ac": "NP_013246", "gene_names_uniprotkb": "RMP1", "gene_names_refseq": "RMP1", "protein_names_uniprotkb": "Ribonuclease MRP protein subunit RMP1; RNA-processing protein RMP1; RNase MRP 23.6 kDa subunit", "protein_names_refseq": "Rmp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR145W)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14562095;14562106;15637077;24374639;9169871", "class_list": "", "function": "Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYD9", "ec_number_list": "", "go_molecular_function": "GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0000460 maturation of 5.8S rRNA;GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q12530-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12532-1", "uniprot_id": "RQC2_YEAST", "mass": 119069.0, "length": 1038, "protein_name": "Ribosome quality control complex subunit 2", "gene_name": "RQC2", "organism": "Yeast", "refseq_name": "Rqc2p", "refseq_ac": "NP_015316", "gene_names_uniprotkb": "RQC2; TAE2; YP8132.04C", "gene_names_refseq": "RQC2; TAE2", "protein_names_uniprotkb": "Ribosome quality control complex subunit 2; Translation-associated element 2", "protein_names_refseq": "Rqc2p", "tax_id": 559292, "disease": "neuromuscular disease (Disease Ontology:DOID:440); neuropathy (Disease Ontology:DOID:870)", "pathway": " (sce:YPL009C); (R-SCE-9954709)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "14562095;14562106;16702403;17563356;18407956;19779198;19795423;19823750;20691087;20702584;21126336;21177495;23178123;23479637;23749301;24374639;25349383;25554787;26934223;27129255;28751611;31133701;32597660;32934225;33481703;33491328;36804914;9169875", "class_list": "", "function": "Key component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes as well as their ubiquitin-mediated proteasomal degradation (PubMed:20691087, PubMed:23178123, PubMed:23479637, PubMed:25349383, PubMed:25554787, PubMed:26934223, PubMed:28751611, PubMed:32934225). Thereby, frees 60S subunit ribosomes from the stalled translation complex and prevents the accumulation of nascent polypeptide chains that are potentially toxic for the cell (PubMed:23178123). Within the RQC complex, RQC2 specifically binds stalled 60S ribosomal subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety and promotes the recruitment of RKR1/LTN1 to stalled 60S subunits (PubMed:23479637, PubMed:25349383). Following binding to stalled 60S ribosomal subunits, RQC2 mediates CAT tailing by recruiting alanine- and threonine-charged tRNA to the A-site and directing the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails) (PubMed:25554787, PubMed:26934223, PubMed:27129255, PubMed:28751611, PubMed:32934225, PubMed:36804914). CAT tails promote the RKR1/LTN1-mediated ubiquitination of incompletely synthesized nascent polypeptides: CAT tailing facilitates RKR1/LTN1-dependent ubiquitination by exposing lysine residues that would otherwise remain buried in the ribosomal exit tunnel (PubMed:28751611, PubMed:32934225). Following ubiquitination, incompletely synthesized nascent polypeptides are recognized by CDC48 and degraded by the proteasome (PubMed:27129255). CAT-tailed proteins tend to aggregate and sequester chaperones and can induce proteotoxic stress; their RKR1/LTN1-dependent ubiquitination and degradation is required to prevent proteotoxic stress (PubMed:26934223, PubMed:27129255, PubMed:31133701)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W403", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:0043023 ribosomal large subunit binding;GO:1904678 alpha-aminoacyl-tRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0010494 cytoplasmic stress granule;GO:1990112 RQC complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0043043 peptide biosynthetic process;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process;GO:0140708 CAT tailing", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q12532-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12674-1", "uniprot_id": "ATC8_YEAST", "mass": 188319.0, "length": 1656, "protein_name": "Probable phospholipid-transporting ATPase DNF3", "gene_name": "DNF3", "organism": "Yeast", "refseq_name": "aminophospholipid-translocating P4-type ATPase DNF3", "refseq_ac": "NP_013885", "gene_names_uniprotkb": "DNF3; YM8520.11C", "gene_names_refseq": "DNF3", "protein_names_uniprotkb": "Probable phospholipid-transporting ATPase DNF3; 7.6.2.1; APT; Aminophospholipid translocase; PLT; Phospholipid translocase", "protein_names_refseq": "aminophospholipid-translocating P4-type ATPase DNF3", "tax_id": 559292, "disease": "hypomyelinating leukodystrophy 24 (Disease Ontology:DOID:0070406); autosomal dominant nonsyndromic deafness 84 (Disease Ontology:DOID:0070604); X-linked congenital hemolytic anemia (Disease Ontology:DOID:0111846)", "pathway": " (sce:YMR162C); (R-SCE-6798695); (R-SCE-936837)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "12631737;16452632;16847258;17093059;17287358;18407956;19411703;19779198;19795423;19823750;20702584;22791719;23749301;24374639;32597660;33481703;33491328;9169872", "class_list": "", "function": "Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine and small amounts of phosphatidylethanolamine from the lumen to the cytosolic leaflet of the trans-Golgi network and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:16452632). May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZY4", "ec_number_list": "3.6.5.2;3.1.3.48;7.6.2.1;2.3.1.51;2.3.1.23;2.3.1.n7;3.1.4.4;1.2.1.3;1.2.1.64", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity;GO:0090554 phosphatidylcholine floppase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0005802 trans-Golgi network;GO:0030140 trans-Golgi network transport vesicle", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0006892 post-Golgi vesicle-mediated transport;GO:0032456 endocytic recycling;GO:0007124 pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q12674-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12680-1", "uniprot_id": "GLT1_YEAST", "mass": 238102.0, "length": 2145, "protein_name": "Glutamate synthase [NADH]", "gene_name": "GLT1", "organism": "Yeast", "refseq_name": "glutamate synthase (NADH)", "refseq_ac": "NP_010110", "gene_names_uniprotkb": "GLT1", "gene_names_refseq": "GLT1", "protein_names_uniprotkb": "Glutamate synthase [NADH]; 1.4.1.14; NADH-GOGAT", "protein_names_refseq": "glutamate synthase (NADH)", "tax_id": 559292, "disease": "dihydropyrimidine dehydrogenase deficiency (Disease Ontology:DOID:14218); pancreatic cancer (Disease Ontology:DOID:1793); gallbladder cancer (Disease Ontology:DOID:3121); liver disease (Disease Ontology:DOID:409); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (sce:YDL171C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;19779198;19795423;19823750;22218487;23749301;24374639;32597660;33481703;33491328;4362465;7047525;7836314;8923741;9169867", "class_list": "", "function": "Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRI0;Q12290", "ec_number_list": "1.4.1.14", "go_molecular_function": "GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor;GO:0005506 iron ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0010181 FMN binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0097268 cytoophidium", "go_biological_process": "GO:0019676 ammonia assimilation cycle;GO:0006537 glutamate biosynthetic process;GO:0097054 L-glutamate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q12680-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12691-1", "uniprot_id": "ATN5_YEAST", "mass": 120296.0, "length": 1091, "protein_name": "Sodium/potassium exporting P-type ATPase 5", "gene_name": "ENA5", "organism": "Yeast", "refseq_name": "putative Na(+)-exporting P-type ATPase ENA5", "refseq_ac": "NP_010323", "gene_names_uniprotkb": "ENA5; YD9673.10c", "gene_names_refseq": "ENA5", "protein_names_uniprotkb": "Sodium/potassium exporting P-type ATPase 5; 7.2.2.3", "protein_names_refseq": "putative Na(+)-exporting P-type ATPase ENA5", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR038C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;16847258;18407956;22329368;23749301;24374639;9169867", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the export of sodium and potassium from the cell (By similarity). May export potassium less efficiently (PubMed:22329368). May transport other cations such as lithium (By similarity). Sodium/potassium efflux ATPases are involved in salt tolerance and maintaining the membrane potential across the plasma membrane in high salinity (Na+) or alkaline (K+) environments (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS26;E9PAF4;P89901", "ec_number_list": "7.2.2.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008554 P-type sodium transporter activity;GO:0016887 ATP hydrolysis activity;GO:0008556 P-type potassium transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0034220 monoatomic ion transmembrane transport;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12691-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12697-1", "uniprot_id": "YPK9_YEAST", "mass": 166750.0, "length": 1472, "protein_name": "Vacuolar cation-transporting ATPase YPK9", "gene_name": "YPK9", "organism": "Yeast", "refseq_name": "putative acid anhydride hydrolase", "refseq_ac": "NP_014934", "gene_names_uniprotkb": "YPK9", "gene_names_refseq": "YPK9", "protein_names_uniprotkb": "Vacuolar cation-transporting ATPase YPK9; 7.2.2.-; PARK9 homolog", "protein_names_refseq": "putative acid anhydride hydrolase", "tax_id": 559292, "disease": "Kufor-Rakeb syndrome (Disease Ontology:DOID:0060556); juvenile-onset Parkinson's disease (Disease Ontology:DOID:0060893); hereditary spastic paraplegia 78 (Disease Ontology:DOID:0112348); Parkinson's disease (Disease Ontology:DOID:14330); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); primary pulmonary hypertension (Disease Ontology:DOID:14557); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (sce:YOR291W); (R-SCE-936837)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "17330950;18407956;19345671;19779198;21126336;22218487;22814378;23749301;24374639;24603074;32597660;33481703;33491328;34965436;9169874", "class_list": "", "function": "Vacuolar transporter which plays a role in sequestration of divalent heavy metal ions., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Y9", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0030145 manganese ion binding;GO:0016887 ATP hydrolysis activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0000329 fungal-type vacuole membrane;GO:1990816 vacuole-mitochondrion membrane contact site", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0006882 intracellular zinc ion homeostasis;GO:0030026 intracellular manganese ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q12697-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12746-1", "uniprot_id": "PGA3_YEAST", "mass": 35287.0, "length": 312, "protein_name": "Plasma membrane-associated coenzyme Q6 reductase PGA3", "gene_name": "PGA3", "organism": "Yeast", "refseq_name": "cytochrome-b5 reductase", "refseq_ac": "NP_013581", "gene_names_uniprotkb": "PGA3; NQR1; YM4987.10C; YM7056.01C", "gene_names_refseq": "NQR1; PGA3", "protein_names_uniprotkb": "Plasma membrane-associated coenzyme Q6 reductase PGA3; 1.6.2.2; Processing of GAS1 and ALP protein 3", "protein_names_refseq": "cytochrome-b5 reductase", "tax_id": 559292, "disease": "estrogen-receptor negative breast cancer (Disease Ontology:DOID:0060076); methemoglobinemia (Disease Ontology:DOID:10783); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (sce:YML125C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;16847258;16943325;19239415;21126336;24374639;9169872", "class_list": "", "function": "NADH-dependent cytochrome b5 reductase that reduces coenzyme Q6 at the plasma membrane and mediates lifespan extension by calorie restriction by shifting fermentative to respiratory metabolism, probably through modulating the NAD(+)/NADH ratio., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0G0", "ec_number_list": "1.6.2.2", "go_molecular_function": "GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q12746-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12748-1", "uniprot_id": "CENPI_YEAST", "mass": 84252.0, "length": 733, "protein_name": "Inner kinetochore subunit CTF3", "gene_name": "CTF3", "organism": "Yeast", "refseq_name": "Ctf3p", "refseq_ac": "NP_013485", "gene_names_uniprotkb": "CTF3; CHL3", "gene_names_refseq": "CHL3; CTF3", "protein_names_uniprotkb": "Inner kinetochore subunit CTF3; CENP-I homolog; Chromosome loss protein 3; Chromosome transmission fidelity protein 3; Constitutive centromere-associated network protein CTF3", "protein_names_refseq": "Ctf3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR381W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11782448;12408861;12589047;14562095;14562106;14690591;22561346;22814378;24374639;3034607;9169871", "class_list": "", "function": "Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation., [UniProtKB]; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ16;Q7LHY6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12748-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q12749-1", "uniprot_id": "SMC6_YEAST", "mass": 128009.0, "length": 1114, "protein_name": "Structural maintenance of chromosomes protein 6", "gene_name": "SMC6", "organism": "Yeast", "refseq_name": "DNA repair protein SMC6", "refseq_ac": "NP_013487", "gene_names_uniprotkb": "SMC6; L3502.2; RHC18", "gene_names_refseq": "RHC18; SMC6", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 6; DNA repair protein RHC18; Rad18 homolog", "protein_names_refseq": "DNA repair protein SMC6", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR383W); (R-SCE-3108214)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562106;14690591;15010319;15738391;22031224;24374639;3034607;33481703;33491328;8524274;9169871", "class_list": "", "function": "Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Probably plays a role in structure., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ18", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0003684 damaged DNA binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0051304 chromosome separation;GO:0071139 resolution of DNA recombination intermediates", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q12749-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E754-1", "uniprot_id": "RS21B_YEAST", "mass": 9760.0, "length": 87, "protein_name": "Small ribosomal subunit protein eS21B", "gene_name": "RPS21B", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS21 RPS21B", "refseq_ac": "NP_012399", "gene_names_uniprotkb": "RPS21B; J0664; RPS25B; RPS26B", "gene_names_refseq": "RPS21B", "protein_names_uniprotkb": "Small ribosomal subunit protein eS21B; 40S ribosomal protein S21-B; S26; YS25", "protein_names_refseq": "40S ribosomal protein eS21 RPS21B", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL136C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 20, "publication_id_list": "10601260;14562095;14562106;14627813;15665377;17563356;18407956;19779198;19795423;19823750;21177495;22096102;22218487;23749301;24374639;24524803;32597660;8641269;8813765;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS21 is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (PubMed:14627813)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW49;P05760", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412 translation;GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3E754-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E757-1", "uniprot_id": "RL11B_YEAST", "mass": 19750.0, "length": 174, "protein_name": "Large ribosomal subunit protein uL5B", "gene_name": "RPL11B", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL5 RPL11B", "refseq_ac": "NP_011599", "gene_names_uniprotkb": "RPL11B; RP39B; RPL16B", "gene_names_refseq": "RPL11B", "protein_names_uniprotkb": "Large ribosomal subunit protein uL5B; 60S ribosomal protein L11-B; L16; RP39; YL22", "protein_names_refseq": "60S ribosomal protein uL5 RPL11B", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 7 (Disease Ontology:DOID:0111878); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (sce:YGR085C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10601260;11283598;14562095;14562106;17115051;17287358;19779198;21126336;21177495;22096102;22522802;22814378;23118189;23749301;24374639;24524803;3023862;37291423;6390341;9169869;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUL7;P06380", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q3E757-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E772-1", "uniprot_id": "LSO2_YEAST", "mass": 10495.0, "length": 92, "protein_name": "Protein LSO2", "gene_name": "LSO2", "organism": "Yeast", "refseq_name": "Lso2p", "refseq_ac": "NP_878080", "gene_names_uniprotkb": "LSO2", "gene_names_refseq": "LSO2; YGR169C-C", "protein_names_uniprotkb": "Protein LSO2; Late-annotated small open reading frame 2", "protein_names_refseq": "Lso2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR169C-A)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12844361;24374639;26450372;29897761;30208026;32687489;33481703;33491328;9169869", "class_list": "", "function": "Ribosome-binding protein involved in ribosome hibernation by associating with translationally inactive ribosomes (PubMed:32687489). Required for translational recovery after starvation from stationary phase (PubMed:30208026, PubMed:32687489). May facilitate rapid translation reactivation by stabilizing the recycling-competent state of inactive ribosomes (PubMed:30208026, PubMed:32687489)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUV3", "ec_number_list": "", "go_molecular_function": "GO:0030371 translation repressor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0006879 intracellular iron ion homeostasis;GO:0002182 cytoplasmic translational elongation;GO:0141014 ribosome hibernation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3E772-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E792-1", "uniprot_id": "RS25A_YEAST", "mass": 12039.0, "length": 108, "protein_name": "Small ribosomal subunit protein eS25A", "gene_name": "RPS25A", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS25 RPS25A", "refseq_ac": "NP_011541", "gene_names_uniprotkb": "RPS25A; RPS31A", "gene_names_refseq": "RPS25A; RPS31A", "protein_names_uniprotkb": "Small ribosomal subunit protein eS25A; 40S ribosomal protein S25-A; RP45; S31; YS23", "protein_names_refseq": "40S ribosomal protein eS25 RPS25A", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR027C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 21, "publication_id_list": "14562095;14562106;16273108;17244705;17287358;18782943;19795423;19823750;20481588;20980660;21109664;21126336;22096102;23749301;24374639;24524803;2856436;33491328;9169869;9290212;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBN4;D6VUG0;P05758;P07282;Q45U56", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006451 translational readthrough", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q3E792-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E7B6-1", "uniprot_id": "VA0E_YEAST", "mass": 8381.0, "length": 73, "protein_name": "V-type proton ATPase subunit e", "gene_name": "VMA9", "organism": "Yeast", "refseq_name": "H(+)-transporting V0 sector ATPase subunit e", "refseq_ac": "NP_958835", "gene_names_uniprotkb": "VMA9; CWH36; LDB10", "gene_names_refseq": "CWH36; LDB10; VMA9", "protein_names_uniprotkb": "V-type proton ATPase subunit e; Low dye-binding protein 10; V-ATPase subunit e; Vacuolar proton pump subunit e", "protein_names_refseq": "H(+)-transporting V0 sector ATPase subunit e", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL005W-A); (R-SCE-1222556); (R-SCE-77387); (R-SCE-917977); (R-SCE-9639288)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "12748633;12844361;14594803;14970230;1574125;24374639;27776355;29526695;33481703", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:14594803). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:14594803)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VR05", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism;GO:0042625 ATPase-coupled ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0000032 cell wall mannoprotein biosynthetic process;GO:0055085 transmembrane transport;GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3E7B6-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E7C1-1", "uniprot_id": "TFB5_YEAST", "mass": 8232.0, "length": 72, "protein_name": "General transcription and DNA repair factor IIH subunit TFB5", "gene_name": "TFB5", "organism": "Yeast", "refseq_name": "TFIIH complex subunit TFB5", "refseq_ac": "NP_076886", "gene_names_uniprotkb": "TFB5", "gene_names_refseq": "TFB5", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH subunit TFB5; RNA polymerase II transcription factor B subunit 5; TFIIH subunit TFB5", "protein_names_refseq": "TFIIH complex subunit TFB5", "tax_id": 559292, "disease": "trichothiodystrophy (Disease Ontology:DOID:0111866); photosensitive trichothiodystrophy 3 (Disease Ontology:DOID:0111871)", "pathway": " (sce:YDR079C-A); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-72086); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-77075)", "pathway_count": 14, "publication_count": 12, "publication_id_list": "14562095;15220919;19172752;19795423;19823750;22411836;24374639;26483468;27610567;7961739;8631896;9169867", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS66", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005675 transcription factor TFIIH holo complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006294 nucleotide-excision repair, preincision complex assembly;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q3E7C1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E7X9-1", "uniprot_id": "RS28A_YEAST", "mass": 7592.0, "length": 67, "protein_name": "Small ribosomal subunit protein eS28A", "gene_name": "RPS28A", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS28 RPS28A", "refseq_ac": "NP_014810", "gene_names_uniprotkb": "RPS28A; O3600; RPS33A; RPS33", "gene_names_refseq": "RPS28A; RPS33A", "protein_names_uniprotkb": "Small ribosomal subunit protein eS28A; 40S ribosomal protein S28-A; S33; YS27", "protein_names_refseq": "40S ribosomal protein eS28 RPS28A", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 15 with mandibulofacial dysostosis (Disease Ontology:DOID:0111894)", "pathway": " (sce:YOR167C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 19, "publication_id_list": "10601260;14562095;14562106;17287358;17322287;21109664;22096102;22218487;22814378;23749301;24374639;24524803;32597660;33481703;33491328;6196722;8972579;9169874;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2M5;P02380", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0006412 translation;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0030490 maturation of SSU-rRNA;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3E7X9-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E840-1", "uniprot_id": "DPH3_YEAST", "mass": 9356.0, "length": 82, "protein_name": "Diphthamide biosynthesis protein 3", "gene_name": "KTI11", "organism": "Yeast", "refseq_name": "Kti11p", "refseq_ac": "NP_660100", "gene_names_uniprotkb": "KTI11; DPH3", "gene_names_refseq": "DPH3; KTI11", "protein_names_uniprotkb": "Diphthamide biosynthesis protein 3; Kluyveromyces lactis toxin-insensitive protein 11", "protein_names_refseq": "Kti11p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL071W-A); (R-SCE-5358493)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "12940988;14562095;14562106;15485916;15952786;18627462;18986986;23645155;24374639;24422557;25543256;25604895;27694803;30608169;31463593;34154323;7813418", "class_list": "", "function": "Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:18627462, PubMed:24422557, PubMed:25543256, PubMed:27694803, PubMed:31463593, PubMed:34154323). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323). Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state (PubMed:34154323). Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM (PubMed:34154323). Together with ATS1; associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex (PubMed:18627462, PubMed:25543256, PubMed:27694803). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:25543256)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPT1", "ec_number_list": "", "go_molecular_function": "GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0008198 ferrous iron binding;GO:0034986 iron chaperone activity;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0017183 protein histidyl modification to diphthamide;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3E840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q3E846-1", "uniprot_id": "COA6_YEAST", "mass": 12445.0, "length": 104, "protein_name": "Cytochrome c oxidase assembly factor 6", "gene_name": "COA6", "organism": "Yeast", "refseq_name": "Coa6p", "refseq_ac": "NP_013972", "gene_names_uniprotkb": "COA6", "gene_names_refseq": "COA6", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 6", "protein_names_refseq": "Coa6p", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); COX deficiency, infantile mitochondrial myopathy (Disease Ontology:DOID:0050713); mitochondrial complex IV deficiency nuclear type 13 (Disease Ontology:DOID:0080360); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (sce:YMR244C-A)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;20922212;22814378;22984289;24374639;24549041;25959673;9169872", "class_list": "", "function": "Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W072", "ec_number_list": "", "go_molecular_function": "GO:0005507 copper ion binding;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3E846-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q6Q547-1", "uniprot_id": "NOP10_YEAST", "mass": 6636.0, "length": 58, "protein_name": "H/ACA ribonucleoprotein complex subunit NOP10", "gene_name": "NOP10", "organism": "Yeast", "refseq_name": "snoRNP complex protein NOP10", "refseq_ac": "NP_058135", "gene_names_uniprotkb": "NOP10", "gene_names_refseq": "NOP10", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit NOP10; Nucleolar protein 10; Nucleolar protein family A member 3; snoRNP protein NOP10", "protein_names_refseq": "snoRNP complex protein NOP10", "tax_id": 559292, "disease": "autosomal recessive dyskeratosis congenita 1 (Disease Ontology:DOID:0070015); dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (sce:YHR072W-A)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;15388873;17287358;17322287;19779198;21131909;22106047;22814378;24374639;32597660;33481703;33491328;8091229;9843512", "class_list": "", "function": "Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512). The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909). The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909). Essential for growth (PubMed:9843512)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL22", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0030515 snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0031429 box H/ACA snoRNP complex;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:0000454 snoRNA guided rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6Q547-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q7LHG5-1", "uniprot_id": "YI31B_YEAST", "mass": 172369.0, "length": 1498, "protein_name": "Transposon Ty3-I Gag-Pol polyprotein", "gene_name": "TY3B-I", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_012184", "gene_names_uniprotkb": "TY3B-I; YILWTy3-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty3-I Gag-Pol polyprotein; Gag3-Pol3; Transposon Ty3-2 TYA-TYB polyprotein; p16; p24; p55", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL082W-A)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16093660;2159534;24374639;2854194;33229814;9169870;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the genomic RNA-nucleocapsid complex., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Nucleocapsid protein p11 (NC) forms the nucleocore that coats the retro-elements dimeric RNA. Binds these RNAs through its zinc fingers (By similarity). Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VVK4;Q04717;Q04722;Q05350", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q7LHG5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92316-1", "uniprot_id": "OST5_YEAST", "mass": 9517.0, "length": 86, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5", "gene_name": "OST5", "organism": "Yeast", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycotransferase subunit", "refseq_ac": "NP_011288", "gene_names_uniprotkb": "OST5; YGL226BC", "gene_names_refseq": "OST5", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5; Oligosaccharyl transferase 9.5 kDa subunit; Oligosaccharyl transferase subunit OST5; Oligosaccharyl transferase subunit zeta", "protein_names_refseq": "dolichyl-diphosphooligosaccharide--protein glycotransferase subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL226C-A)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11580295;14562095;14562106;15886282;16096345;16096346;16297388;24374639;29301962;29466327;33491328;8175708;9135133;9169869;9405463;9878773", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVA8;P87030", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q92316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92325-1", "uniprot_id": "LAG2_YEAST", "mass": 75639.0, "length": 660, "protein_name": "Cullin-associated NEDD8-dissociated protein 1 homolog", "gene_name": "LAG2", "organism": "Yeast", "refseq_name": "Lag2p", "refseq_ac": "NP_014617", "gene_names_uniprotkb": "LAG2", "gene_names_refseq": "ECM36; LAG2", "protein_names_uniprotkb": "Cullin-associated NEDD8-dissociated protein 1 homolog; CAND1 homolog; Longevity-assurance protein 2", "protein_names_refseq": "Lag2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL025W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;19763088;19942853;24374639;8760941;9169874", "class_list": "", "function": "Assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (By similarity). Involved in the aging process. Longevity-assurance protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W240;Q08175", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q92325-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q92393-1", "uniprot_id": "YO12B_YEAST", "mass": 198537.0, "length": 1755, "protein_name": "Transposon Ty1-OR Gag-Pol polyprotein", "gene_name": "TY1B-OR", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_058183", "gene_names_uniprotkb": "TY1B-OR; O3367; YOR3367W; YORWTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-OR Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR142W-B)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16093660;16093680;19684113;24374639;9169874;9200815;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W2J9", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q92393-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q96VH5-1", "uniprot_id": "MIC10_YEAST", "mass": 10408.0, "length": 97, "protein_name": "MICOS complex subunit MIC10", "gene_name": "MIC10", "organism": "Yeast", "refseq_name": "Mic10p", "refseq_ac": "NP_065435", "gene_names_uniprotkb": "MIC10; MCS10; MIO10; MOS1", "gene_names_refseq": "MCS10; MIC10; MIO10; MOS1", "protein_names_uniprotkb": "MICOS complex subunit MIC10; MitOS1; Mitochondrial contact site complex 10 kDa subunit; Mitochondrial inner membrane organization component of 10 kDa; Mitochondrial organizing structure protein 1", "protein_names_refseq": "Mic10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL057C-A)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1574125;16823961;21126336;21944719;21987634;22009199;22114354;24374639;24687277;33491328", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQV9", "ec_number_list": "", "go_molecular_function": "GO:0140260 mitochondrial proton-transporting ATP synthase complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex", "go_biological_process": "GO:0097753 membrane bending;GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q96VH5-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99190-1", "uniprot_id": "TECR_YEAST", "mass": 36768.0, "length": 310, "protein_name": "Very-long-chain enoyl-CoA reductase", "gene_name": "TSC13", "organism": "Yeast", "refseq_name": "trans-2-enoyl-CoA reductase (NADPH) TSC13", "refseq_ac": "NP_010269", "gene_names_uniprotkb": "TSC13; D2865", "gene_names_refseq": "TSC13", "protein_names_uniprotkb": "Very-long-chain enoyl-CoA reductase; 1.3.1.93; Enoyl reductase TSC13; Temperature-sensitive CSG2 suppressor protein 13; Trans-2-enoyl-CoA reductase", "protein_names_refseq": "trans-2-enoyl-CoA reductase (NADPH) TSC13", "tax_id": 559292, "disease": "non-syndromic intellectual disability (Disease Ontology:DOID:0050889); catecholaminergic polymorphic ventricular tachycardia 3 (Disease Ontology:DOID:0060677); autosomal recessive intellectual developmental disorder 14 (Disease Ontology:DOID:0081188)", "pathway": " (sce:YDL015C); (R-SCE-75876)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11113186;12087109;14562095;14562106;15958487;16847258;17719544;22814378;24374639;9169867", "class_list": "", "function": "Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. VLCFAs serve for instance as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRX4", "ec_number_list": "1.3.1.93", "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0102758 very-long-chain enoyl-CoA reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006665 sphingolipid metabolic process;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99190-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99210-1", "uniprot_id": "NTPPA_YEAST", "mass": 26477.0, "length": 232, "protein_name": "dTTP/UTP pyrophosphatase", "gene_name": "O3237; YOR3237W", "organism": "Yeast", "refseq_name": "nucleotide diphosphatase", "refseq_ac": "NP_014754", "gene_names_uniprotkb": "O3237; YOR3237W", "gene_names_refseq": "", "protein_names_uniprotkb": "dTTP/UTP pyrophosphatase; 3.6.1.9; Maf-like protein YOR111W; Nucleoside triphosphate pyrophosphatase; Nucleotide PPase; Nucleotide pyrophosphatase; dTTPase/UTPase", "protein_names_refseq": "nucleotide diphosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR111W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562106;17322287;24210219;24374639;33491328;8904341;9169874;9200815", "class_list": "", "function": "Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze the modified nucleotides 5-methyl-UTP (m(5)UTP) and pseudo-UTP. Has weak activity with CTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2H0", "ec_number_list": "3.6.1.9", "go_molecular_function": "GO:0047429 nucleoside triphosphate diphosphatase activity;GO:0036221 UTP diphosphatase activity;GO:0036218 dTTP diphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99210-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99216-1", "uniprot_id": "PNO1_YEAST", "mass": 30332.0, "length": 274, "protein_name": "Pre-rRNA-processing protein PNO1", "gene_name": "PNO1", "organism": "Yeast", "refseq_name": "Pno1p", "refseq_ac": "NP_014788", "gene_names_uniprotkb": "PNO1; DIM2; O3513; RRP20; YOR3513C", "gene_names_refseq": "DIM2; PNO1; RRP20", "protein_names_uniprotkb": "Pre-rRNA-processing protein PNO1; Partner of NOB1; Ribosomal RNA-processing protein 20", "protein_names_refseq": "Pno1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR145C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10923024;12502737;12628929;12736301;15037774;19779198;21126336;22814378;23749301;24374639;32597660;33229814;33481703;33491328;9046089;9169874;9200815", "class_list": "", "function": "Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species. Recruits DIM1 to nucleolar pre-RNAs. Indirectly required for cleavage at the A2 site of the 20S pre-rRNA, forming 18S rRNA, and at A1 and A2 sites of other pre-rRNAs., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6W2K3;Q02462;Q7LHP7", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030686 90S preribosome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0043248 proteasome assembly;GO:0042255 ribosome assembly;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q99216-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99219-1", "uniprot_id": "YI31A_YEAST", "mass": 34100.0, "length": 290, "protein_name": "Transposon Ty3-I Gag polyprotein", "gene_name": "TY3A-I", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "TY3A-I; YILWTy3-1 GAG", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty3-I Gag polyprotein; Gag3; TY3A; Transposon Ty3-2 protein A; p24; p7", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "16093660;17322287;24374639;2854194;9169870;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome., [UniProtKB]; Nucleocapsid protein p9 (NC) forms the nucleocore that coats the retro-elements dimeric RNA. Binds these RNAs through its zinc fingers (By similarity). Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000943 retrotransposon nucleocapsid", "go_biological_process": "GO:0032197 retrotransposition;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99219-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99222-1", "uniprot_id": "AFI1_YEAST", "mass": 102250.0, "length": 893, "protein_name": "ARF3-interacting protein 1", "gene_name": "AFI1", "organism": "Yeast", "refseq_name": "Afi1p", "refseq_ac": "NP_014772", "gene_names_uniprotkb": "AFI1; YOR3296C", "gene_names_refseq": "AFI1", "protein_names_uniprotkb": "ARF3-interacting protein 1", "protein_names_refseq": "Afi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR129C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14515169;14562106;18397879;18407956;23749301;24374639;32597660;33481703;33491328;8798783;8904341;9169874;9200815", "class_list": "", "function": "Involved in actin patch polarization. Required for maintaining a proper budding pattern in yeast cells. Required for proper polarized localization of the ADP-ribosylation factor ARF3 at the plasma membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2I7;Q92274", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051666 actin cortical patch localization;GO:0000282 cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99222-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99258-1", "uniprot_id": "RIB3_YEAST", "mass": 22568.0, "length": 208, "protein_name": "3,4-dihydroxy-2-butanone 4-phosphate synthase", "gene_name": "RIB3", "organism": "Yeast", "refseq_name": "3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3", "refseq_ac": "NP_010775", "gene_names_uniprotkb": "RIB3; D8035.30", "gene_names_refseq": "RIB3", "protein_names_uniprotkb": "3,4-dihydroxy-2-butanone 4-phosphate synthase; 4.1.99.12; DHBP synthase", "protein_names_refseq": "3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR487C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12595523;14562095;14562106;17322287;17563356;19779198;21565288;24374639;32597660;33481703;33491328;7559556;9169867", "class_list": "", "function": "Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (Probable). Also has an unrelated function in expression of mitochondrial respiration (PubMed:12595523)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTB0", "ec_number_list": "4.1.99.12", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0009231 riboflavin biosynthetic process;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q99258-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99271-1", "uniprot_id": "NAH1_YEAST", "mass": 109369.0, "length": 985, "protein_name": "Na(+)/H(+) antiporter", "gene_name": "NHA1", "organism": "Yeast", "refseq_name": "Nha1p", "refseq_ac": "NP_013239", "gene_names_uniprotkb": "NHA1; L3149; L9606.4", "gene_names_refseq": "NHA1", "protein_names_uniprotkb": "Na(+)/H(+) antiporter", "protein_names_refseq": "Nha1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR138W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "14562106;15294160;15665377;16402204;16847258;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;22329368;23749301;24374639;32597660;33481703;33491328;8654575;9169871", "class_list": "", "function": "Sodium export from cell, takes up external protons in exchange for internal sodium ions (Probable). Also capable of exporting potassium ions (PubMed:22329368)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 37, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYD3", "ec_number_list": "", "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015079 potassium ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0042391 regulation of membrane potential;GO:0035725 sodium ion transmembrane transport;GO:0030003 intracellular monoatomic cation homeostasis;GO:0030007 intracellular potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q99271-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99287-1", "uniprot_id": "SEY1_YEAST", "mass": 89432.0, "length": 776, "protein_name": "Protein SEY1", "gene_name": "SEY1", "organism": "Yeast", "refseq_name": "dynamin-like GTPase SEY1", "refseq_ac": "NP_014808", "gene_names_uniprotkb": "SEY1; O3590", "gene_names_refseq": "SEY1", "protein_names_uniprotkb": "Protein SEY1; 3.6.5.-; Synthetic enhancer of YOP1 protein", "protein_names_refseq": "dynamin-like GTPase SEY1", "tax_id": 559292, "disease": "hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (sce:YOR165W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11292078;12427979;14562095;14562106;16847258;19665976;19795423;19823750;24374639;33229814;33481703;33491328;8972579;9169874", "class_list": "", "function": "Cooperates with the reticulon proteins RTN1 and RTN2 and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2M3", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0061024 membrane organization;GO:0007029 endoplasmic reticulum organization;GO:0016320 endoplasmic reticulum membrane fusion;GO:0048309 endoplasmic reticulum inheritance", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99287-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99312-1", "uniprot_id": "ISN1_YEAST", "mass": 51330.0, "length": 450, "protein_name": "IMP-specific 5'-nucleotidase 1", "gene_name": "ISN1", "organism": "Yeast", "refseq_name": "IMP 5'-nucleotidase", "refseq_ac": "NP_014798", "gene_names_uniprotkb": "ISN1; O3548", "gene_names_refseq": "ISN1", "protein_names_uniprotkb": "IMP-specific 5'-nucleotidase 1; 3.1.3.99", "protein_names_refseq": "IMP 5'-nucleotidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR155C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12735798;14562106;18407956;19779198;21126336;23749301;24374639;33481703;33491328;8141771;9046089;9169874", "class_list": "", "function": "IMP-specific 5'-nucleotidase involved in IMP (inosine 5'-phosphate) degradation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2L2", "ec_number_list": "3.1.3.99", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0008253 5'-nucleotidase activity", "go_cellular_component": "", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0006190 inosine salvage;GO:0071590 nicotinamide riboside biosynthetic process;GO:0071592 nicotinic acid riboside biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99312-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99314-1", "uniprot_id": "SAS5_YEAST", "mass": 29018.0, "length": 248, "protein_name": "Something about silencing protein 5", "gene_name": "SAS5", "organism": "Yeast", "refseq_name": "Sas5p", "refseq_ac": "NP_014856", "gene_names_uniprotkb": "SAS5", "gene_names_refseq": "SAS5", "protein_names_uniprotkb": "Something about silencing protein 5", "protein_names_refseq": "Sas5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR213C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10471696;10471697;11731479;11731480;12626510;14562106;16079223;18407956;24374639;33491328;8840505;9169874", "class_list": "", "function": "Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing. In the complex, SAS5 is required for maximal histone acetyltransferase (HAT) activity of the complex, suggesting that it may be required to stabilize the complex or help in substrate recognition., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2R9", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding;GO:0004402 histone acetyltransferase activity;GO:0016407 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0031011 Ino80 complex;GO:0000785 chromatin;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99314-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99315-1", "uniprot_id": "YG31B_YEAST", "mass": 178307.0, "length": 1547, "protein_name": "Transposon Ty3-G Gag-Pol polyprotein", "gene_name": "TY3B-G", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_011624", "gene_names_uniprotkb": "TY3B-G; G5984; YGRWTy3-1 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty3-G Gag-Pol polyprotein; Gag3-Pol3; Transposon Ty3-1 TYA-TYB polyprotein; p16; p24; p55", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR109W-B)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10593967;11152529;1371165;15956549;16093660;17330950;2159534;24374639;2447089;24608367;34848735;7515969;7677953;8267715;8905931;9169869;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the genomic RNA-nucleocapsid complex., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome., [UniProtKB]; Nucleocapsid protein p11 (NC) forms the nucleocore that coats the retro-elements dimeric RNA. Binds these RNAs through its zinc fingers (By similarity). Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VUP1;Q07096", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99315-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99321-1", "uniprot_id": "DDP1_YEAST", "mass": 21572.0, "length": 188, "protein_name": "Diphosphoinositol polyphosphate phosphohydrolase DDP1", "gene_name": "DDP1", "organism": "Yeast", "refseq_name": "polyphosphatase DDP1", "refseq_ac": "NP_014806", "gene_names_uniprotkb": "DDP1; O3575", "gene_names_refseq": "DDP1", "protein_names_uniprotkb": "Diphosphoinositol polyphosphate phosphohydrolase DDP1; 3.6.1.10; 3.6.1.52; 3.6.1.60; Ap6A hydrolase; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase; Diadenosine and diphosphoinositol polyphosphate phosphohydrolase 1; Diadenosine hexaphosphate hydrolase (AMP-forming); Endopolyphosphatase", "protein_names_refseq": "polyphosphatase DDP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR163W); (R-SCE-1855167)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10085096;10419486;14562095;14562106;17322287;18407956;21126336;22814378;24374639;31175919;33481703;33491328;33893105;8972579;9169874", "class_list": "", "function": "May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate (p5A), and adenosine 5'-tetraphosphate (p4A) are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate) (PubMed:10085096, PubMed:10419486). Also has endopolyphosphatase activity (PubMed:31175919)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2M1", "ec_number_list": "3.6.1.10;3.6.1.-;3.6.1.11;3.6.1.52;3.6.1.60", "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0015961 diadenosine polyphosphate catabolic process;GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:1901907 diadenosine pentaphosphate catabolic process;GO:1901909 diadenosine hexaphosphate catabolic process;GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99337-1", "uniprot_id": "YN12B_YEAST", "mass": 198198.0, "length": 1749, "protein_name": "Transposon Ty1-NL2 Gag-Pol polyprotein", "gene_name": "TY1B-NL2", "organism": "Yeast", "refseq_name": "gag-pol fusion protein", "refseq_ac": "NP_001268465", "gene_names_uniprotkb": "TY1B-NL2; N2453; YNLWTy1-2 POL", "gene_names_refseq": "", "protein_names_uniprotkb": "Transposon Ty1-NL2 Gag-Pol polyprotein; Gag-Pol-p199; Gag-p45; Pol-p20; Pol-p63; Pol-p71; TY1A-TY1B; Transposon Ty1 TYA-TYB polyprotein; p190; p23; p54; p60; p84; p90", "protein_names_refseq": "gag-pol fusion protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL054W-B)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16093660;16093680;24374639;9169873;9582191", "class_list": "", "function": "Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA also has nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)., [UniProtKB]; Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome (By similarity)., [UniProtKB]; Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends (By similarity)., [UniProtKB]; The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "S6G3B3", "ec_number_list": "2.7.7.7;3.1.26.4;2.7.7.49;3.4.23.-;3.1.11.-", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003964 RNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006310 DNA recombination;GO:0006508 proteolysis;GO:0032196 transposition;GO:0015074 DNA integration;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99337-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q99385-1", "uniprot_id": "VCX1_YEAST", "mass": 44646.0, "length": 411, "protein_name": "Vacuolar calcium ion transporter", "gene_name": "VCX1", "organism": "Yeast", "refseq_name": "Vcx1p", "refseq_ac": "NP_010155", "gene_names_uniprotkb": "VCX1; HUM1; MNR1", "gene_names_refseq": "HUM1; MNR1; VCX1", "protein_names_uniprotkb": "Vacuolar calcium ion transporter; High copy number undoes manganese protein 1; Manganese resistance 1 protein; Vacuolar Ca(2+)/H(+) exchanger", "protein_names_refseq": "Vcx1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDL128W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10219995;14562106;15665377;16847258;22118465;22218487;22814378;24374639;32597660;33481703;33491328;34965436;8628289;8668190;9169867", "class_list": "", "function": "Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRM2;O13580;O13581", "ec_number_list": "", "go_molecular_function": "GO:0015386 potassium:proton antiporter activity;GO:0046872 metal ion binding;GO:0015369 calcium:proton antiporter activity", "go_cellular_component": "GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99385-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ZZW7-1", "uniprot_id": "MBI3_YEAST", "mass": 61172.0, "length": 517, "protein_name": "Cytochrome b mRNA maturase bI3", "gene_name": "BI3", "organism": "Yeast", "refseq_name": "cytochrome b mRNA maturase bI3", "refseq_ac": "NP_009317", "gene_names_uniprotkb": "BI3", "gene_names_refseq": "BI3", "protein_names_uniprotkb": "Cytochrome b mRNA maturase bI3", "protein_names_refseq": "cytochrome b mRNA maturase bI3", "tax_id": 559292, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); ovarian carcinoma (Disease Ontology:DOID:4001); thyrotoxicosis (Disease Ontology:DOID:7997); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:Q0115)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11773622;12924947;16116439;24374639;2538624;9872396", "class_list": "", "function": "Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (COB) gene, containing its own coding sequence. In vivo splicing requires the formation of a ribonucleoprotein complex together with the imported mitochondrial RNA-splicing protein MRS1. The complex seems to stimulate the intrinsic ribozyme activity of intron bI3 through binding to and stabilizing specific secondary and tertiary structure elements in the RNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7NYF0;Q36758", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0009055 electron transfer activity;GO:0016491 oxidoreductase activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006397 mRNA processing;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0090615 mitochondrial mRNA processing;GO:0000372 Group I intron splicing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ZZW7-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q9ZZX1-1", "uniprot_id": "SCE4_YEAST", "mass": 72165.0, "length": 630, "protein_name": "Intron-encoded DNA endonuclease aI5 alpha", "gene_name": "AI5_ALPHA", "organism": "Yeast", "refseq_name": "intron-encoded DNA endonuclease aI5 alpha", "refseq_ac": "NP_009306", "gene_names_uniprotkb": "AI5_ALPHA; I-SCEIV", "gene_names_refseq": "AI5_ALPHA", "protein_names_uniprotkb": "Intron-encoded DNA endonuclease aI5 alpha; DNA endonuclease I-SceIV; Intron-encoded endonuclease I-SceIV", "protein_names_refseq": "intron-encoded DNA endonuclease aI5 alpha", "tax_id": 559292, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:Q0070)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1314207;24374639;9675098;9872396", "class_list": "", "function": "Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-ATCTTCTCTTGATTAGCCCTGATCTACGG-3' after the nucleotide sequence ATTA leaving a four-base overhang and a 3'-OH., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A7NYD1;Q8W770", "ec_number_list": "", "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0020037 heme binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration;GO:0006316 movement of group I intron", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ZZX1-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P0C074-1", "uniprot_id": "YSF3_YEAST", "mass": 10027.0, "length": 85, "protein_name": "RDS3 complex subunit 10", "gene_name": "YSF3", "organism": "Yeast", "refseq_name": "U2 snRNP complex subunit YSF3", "refseq_ac": "NP_878153", "gene_names_uniprotkb": "YSF3; RCP10", "gene_names_refseq": "RCP10; YSF3", "protein_names_uniprotkb": "RDS3 complex subunit 10; Splicing factor 3b subunit", "protein_names_refseq": "U2 snRNP complex subunit YSF3", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL138W-A)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12844361;15565172;16314500;24374639;9169873", "class_list": "", "function": "Involved in pre-mRNA splicing. Required for the SF3b integrity and prespliceosome assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W143", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C074-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P14359-1", "uniprot_id": "SNA3_YEAST", "mass": 15199.0, "length": 133, "protein_name": "Protein SNA3", "gene_name": "SNA3", "organism": "Yeast", "refseq_name": "Sna3p", "refseq_ac": "NP_012384", "gene_names_uniprotkb": "SNA3; J0630", "gene_names_refseq": "SNA3", "protein_names_uniprotkb": "Protein SNA3", "protein_names_refseq": "Sna3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL151C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11566881;12872131;14557538;14562095;14562106;16847258;17322287;17563356;22106047;24374639;2642902;8641269;8813765", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW35;Q6B236", "ec_number_list": "", "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0016020 membrane;GO:0031902 late endosome membrane;GO:0000324 fungal-type vacuole;GO:0000328 fungal-type vacuole lumen", "go_biological_process": "GO:0030163 protein catabolic process;GO:0032509 endosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P14359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P18634-1", "uniprot_id": "ART10_YEAST", "mass": 59758.0, "length": 518, "protein_name": "Arrestin-related trafficking adapter 10", "gene_name": "ART10", "organism": "Yeast", "refseq_name": "Art10p", "refseq_ac": "NP_013496", "gene_names_uniprotkb": "ART10; L8084.13", "gene_names_refseq": "ART10", "protein_names_uniprotkb": "Arrestin-related trafficking adapter 10", "protein_names_refseq": "Art10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR392C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;17551511;18976803;2141026;22106047;23749301;24374639;33491328;9169871", "class_list": "", "function": "May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ27", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P18634-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P20053-1", "uniprot_id": "PRP4_YEAST", "mass": 52442.0, "length": 465, "protein_name": "U4/U6 small nuclear ribonucleoprotein PRP4", "gene_name": "PRP4", "organism": "Yeast", "refseq_name": "U4/U6-U5 snRNP complex subunit PRP4", "refseq_ac": "NP_015504", "gene_names_uniprotkb": "PRP4; P9705.6; RNA4", "gene_names_refseq": "PRP4; RNA4", "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein PRP4; Pre-mRNA-processing protein 4", "protein_names_refseq": "U4/U6-U5 snRNP complex subunit PRP4", "tax_id": 559292, "disease": "retinitis pigmentosa 70 (Disease Ontology:DOID:0110392); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (sce:YPR178W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10449419;14562106;18407956;24374639;2528686;2528687;33491328;9169875", "class_list": "", "function": "Involved in RNA splicing. Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4H8", "ec_number_list": "", "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0034247 snoRNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000393 spliceosomal conformational changes to generate catalytic conformation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P20053-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P21339-1", "uniprot_id": "MSB1_YEAST", "mass": 129971.0, "length": 1137, "protein_name": "Morphogenesis-related protein MSB1", "gene_name": "MSB1", "organism": "Yeast", "refseq_name": "Msb1p", "refseq_ac": "NP_014831", "gene_names_uniprotkb": "MSB1", "gene_names_refseq": "MSB1", "protein_names_uniprotkb": "Morphogenesis-related protein MSB1; Multicopy suppressor of bud emergence 1", "protein_names_refseq": "Msb1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR188W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562106;17330950;17563356;18407956;19684113;19779198;19795423;19823750;1996092;20702584;21177495;23749301;24374639;30516470;32597660;33481703;33491328;9169874", "class_list": "", "function": "May play a role in polarity establishment and bud formation. The MSB1 gene may be functionally redundant., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 52, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W2P4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0030427 site of polarized growth;GO:0005934 cellular bud tip", "go_biological_process": "GO:0030010 establishment of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P21339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25558-1", "uniprot_id": "BUD3_YEAST", "mass": 184719.0, "length": 1636, "protein_name": "Bud site selection protein 3", "gene_name": "BUD3", "organism": "Yeast", "refseq_name": "Bud3p", "refseq_ac": "NP_009914", "gene_names_uniprotkb": "BUD3; YCL012W; YCL013W; YCL12W; YCL13W; YCL14W", "gene_names_refseq": "BUD3; YCL012W", "protein_names_uniprotkb": "Bud site selection protein 3", "protein_names_refseq": "Bud3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL014W)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "15665377;1574125;17287358;17330950;17460121;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22106047;22218487;23749301;24374639;24909858;30516470;32597660;33229814;33481703;33491328;34965436;7730410", "class_list": "", "function": "Co-assembles with BUD4 at bud sites. BUD4 and BUD3 may cooperate to recognize a spatial landmark (the neck filaments) during mitosis and they subsequently become a landmark for establishing the axial budding pattern in G1., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 124, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VQZ9;P25556;P25557;P87007", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000142 cellular bud neck contractile ring;GO:0005935 cellular bud neck", "go_biological_process": "GO:0000755 cytogamy;GO:0007120 axial cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P25558-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25569-1", "uniprot_id": "GID7_YEAST", "mass": 84517.0, "length": 745, "protein_name": "GID complex subunit 7", "gene_name": "GID7", "organism": "Yeast", "refseq_name": "glucose-induced degradation complex subunit GID7", "refseq_ac": "NP_009891", "gene_names_uniprotkb": "GID7; MOH2; YCL311; YCL39W", "gene_names_refseq": "GID7; MOH2", "protein_names_uniprotkb": "GID complex subunit 7; Glucose-induced degradation protein 7", "protein_names_refseq": "glucose-induced degradation complex subunit GID7", "tax_id": 559292, "disease": "", "pathway": " (sce:YCL039W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "12686616;14562095;14562106;14566057;1523890;1574125;17563356;18407956;18508925;19779198;22645139;23749301;24374639;33481703;33491328;33502312;33905682", "class_list": "", "function": "Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations (PubMed:18508925, PubMed:33905682). Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:18508925). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes (PubMed:12686616, PubMed:18508925, PubMed:22645139)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQX6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0034657 GID complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045721 negative regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P25569-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25632-1", "uniprot_id": "RSC6_YEAST", "mass": 54165.0, "length": 483, "protein_name": "Chromatin structure-remodeling complex protein RSC6", "gene_name": "RSC6", "organism": "Yeast", "refseq_name": "Rsc6p", "refseq_ac": "NP_009981", "gene_names_uniprotkb": "RSC6; YCR52W", "gene_names_refseq": "RSC6", "protein_names_uniprotkb": "Chromatin structure-remodeling complex protein RSC6; Remodel the structure of chromatin complex subunit 6", "protein_names_refseq": "Rsc6p", "tax_id": 559292, "disease": "Coffin-Siris syndrome 11 (Disease Ontology:DOID:0112372); familial hyperlipidemia (Disease Ontology:DOID:1168); alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (sce:YCR052W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10025404;10329629;10619019;12072455;12183366;12697820;14562106;1574125;17322287;19779198;21126336;23749301;24374639;33491328;8980231;9685490", "class_list": "", "function": "Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VR60", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006337 nucleosome disassembly;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P25632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32464-1", "uniprot_id": "HYM1_YEAST", "mass": 45853.0, "length": 399, "protein_name": "Protein HYM1", "gene_name": "HYM1", "organism": "Yeast", "refseq_name": "Hym1p", "refseq_ac": "NP_012732", "gene_names_uniprotkb": "HYM1", "gene_names_refseq": "HYM1", "protein_names_uniprotkb": "Protein HYM1", "protein_names_refseq": "Hym1p", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (sce:YKL189W); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10655212;14562106;19779198;24374639;33491328;8154185;8196765;8394042", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VX11", "ec_number_list": "", "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0000131 incipient cellular bud site;GO:0005933 cellular bud;GO:0043332 mating projection tip;GO:0044732 mitotic spindle pole body", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0035556 intracellular signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0007118 budding cell apical bud growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32464-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32786-1", "uniprot_id": "RRN6_YEAST", "mass": 102049.0, "length": 894, "protein_name": "RNA polymerase I-specific transcription initiation factor RRN6", "gene_name": "RRN6", "organism": "Yeast", "refseq_name": "Rrn6p", "refseq_ac": "NP_009539", "gene_names_uniprotkb": "RRN6; YBL0311; YBL0312", "gene_names_refseq": "RRN6", "protein_names_uniprotkb": "RNA polymerase I-specific transcription initiation factor RRN6", "protein_names_refseq": "Rrn6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL014C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1332308;14562095;14562106;24374639;33491328;7813418;7958901;8702872;8887672;8895657", "class_list": "", "function": "Acts as a component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPY6", "ec_number_list": "", "go_molecular_function": "GO:0001179 RNA polymerase I general transcription initiation factor binding;GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070860 RNA polymerase I core factor complex", "go_biological_process": "GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32786-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33204-1", "uniprot_id": "ARPC4_YEAST", "mass": 19916.0, "length": 171, "protein_name": "Actin-related protein 2/3 complex subunit 4", "gene_name": "ARC19", "organism": "Yeast", "refseq_name": "Arc19p", "refseq_ac": "NP_012912", "gene_names_uniprotkb": "ARC19; YKL166", "gene_names_refseq": "ARC19", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 4; Arp2/3 complex 20 kDa; p20-ARC", "protein_names_refseq": "Arc19p", "tax_id": 559292, "disease": "Down syndrome (Disease Ontology:DOID:14250); cancer (Disease Ontology:DOID:162); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (sce:YKL013C); (R-SCE-2029482); (R-SCE-5663213)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "14562106;1481574;17322287;24374639;33491328;8154185;8196765;9210376", "class_list": "", "function": "Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXS3", "ec_number_list": "", "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0005885 Arp2/3 protein complex;GO:0030479 actin cortical patch", "go_biological_process": "GO:0030041 actin filament polymerization;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0045010 actin nucleation;GO:0044396 actin cortical patch organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P33204-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35178-1", "uniprot_id": "RRP1_YEAST", "mass": 33203.0, "length": 278, "protein_name": "Ribosomal RNA-processing protein 1", "gene_name": "RRP1", "organism": "Yeast", "refseq_name": "Rrp1p", "refseq_ac": "NP_010372", "gene_names_uniprotkb": "RRP1; D4478", "gene_names_refseq": "RRP1", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 1", "protein_names_refseq": "Rrp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR087C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10341208;14562106;17330950;19779198;22814378;24374639;33491328;8223425;9169867", "class_list": "", "function": "Required for 27S rRNA processing to 25S and 5.8S., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS74", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35178-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P35719-1", "uniprot_id": "MRP8_YEAST", "mass": 25097.0, "length": 219, "protein_name": "Uncharacterized protein MRP8", "gene_name": "MRP8", "organism": "Yeast", "refseq_name": "Mrp8p", "refseq_ac": "NP_012780", "gene_names_uniprotkb": "MRP8; YKL3", "gene_names_refseq": "MRP8; YKL3", "protein_names_uniprotkb": "Uncharacterized protein MRP8", "protein_names_refseq": "Mrp8p", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL142W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "14562095;14562106;15166219;1574929;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20190278;23749301;24374639;32597660;33481703;33491328;8196765", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX54", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P35719-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36008-1", "uniprot_id": "EF1G2_YEAST", "mass": 46520.0, "length": 412, "protein_name": "Elongation factor 1-gamma 2", "gene_name": "TEF4", "organism": "Yeast", "refseq_name": "translation elongation factor EF1B gamma", "refseq_ac": "NP_012842", "gene_names_uniprotkb": "TEF4; EFC1", "gene_names_refseq": "EFC1; TEF4", "protein_names_uniprotkb": "Elongation factor 1-gamma 2; EF-1-gamma 2; Eukaryotic elongation factor 1Bgamma 2; Translation elongation factor 1B gamma 2; eEF1Bgamma 2", "protein_names_refseq": "translation elongation factor EF1B gamma", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL081W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;1730668;18407956;19779198;19795423;19823750;22814378;23749301;24374639;32597660;33481703;33491328;8041634;8196765", "class_list": "", "function": "Subunit of the eukaryotic elongation factor 1 complex (eEF1). Probably plays a role in anchoring the complex to other cellular components (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXK6", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005840 ribosome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36008-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36069-1", "uniprot_id": "PMU1_YEAST", "mass": 33776.0, "length": 295, "protein_name": "Probable phosphoglycerate mutase PMU1", "gene_name": "PMU1", "organism": "Yeast", "refseq_name": "putative phosphomutase", "refseq_ac": "NP_012794", "gene_names_uniprotkb": "PMU1", "gene_names_refseq": "PMU1", "protein_names_uniprotkb": "Probable phosphoglycerate mutase PMU1; 5.4.-.-; Phosphomutase homolog 1", "protein_names_refseq": "putative phosphomutase", "tax_id": 559292, "disease": "", "pathway": " (sce:YKL128C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;17322287;24374639;33491328;8196765;8913738", "class_list": "", "function": "Probable phosphomutase that may have a function related to the manipulation of phosphate groups on carbohydrates. Reduces trehalose-6-phosphate levels when overexpressed in TPS2-deleted cells. Reduces 5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR) levels, a metabolic intermediate at the crossroads between AMP and histidine biosynthesis pathways, when overexpressed in a ADE3-ADE16-ADE17 triple deletant., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX67;E9P8Y9", "ec_number_list": "", "go_molecular_function": "GO:0016853 isomerase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36097-1", "uniprot_id": "TTI1_YEAST", "mass": 118889.0, "length": 1038, "protein_name": "TEL2-interacting protein 1", "gene_name": "TTI1", "organism": "Yeast", "refseq_name": "Tti1p", "refseq_ac": "NP_012892", "gene_names_uniprotkb": "TTI1; FMP47; YKL246", "gene_names_refseq": "TTI1", "protein_names_uniprotkb": "TEL2-interacting protein 1", "protein_names_refseq": "Tti1p", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YKL033W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;17563356;18407956;19040720;19779198;20702584;20801936;21177495;24374639;30516470;32597660;33491328;8196765;8203146", "class_list": "", "function": "Component of the ASTRA complex involved in chromatin remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXQ3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0110078 TTT Hsp90 cochaperone complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0006325 chromatin organization;GO:2000003 positive regulation of DNA damage checkpoint", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P36097-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P36141-1", "uniprot_id": "FMP46_YEAST", "mass": 15650.0, "length": 133, "protein_name": "Putative redox protein FMP46, mitochondrial", "gene_name": "FMP46", "organism": "Yeast", "refseq_name": "putative redox protein", "refseq_ac": "NP_012975", "gene_names_uniprotkb": "FMP46", "gene_names_refseq": "FMP46", "protein_names_uniprotkb": "Putative redox protein FMP46, mitochondrial; 1.-.-.-; Found in mitochondrial proteome protein 46", "protein_names_refseq": "putative redox protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YKR049C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;14576278;16202234;17322287;24374639;8196765", "class_list": "", "function": "Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXB0", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0051051 negative regulation of transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36141-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38081-1", "uniprot_id": "YBQ6_YEAST", "mass": 57822.0, "length": 501, "protein_name": "Uncharacterized glycosyl hydrolase YBR056W", "gene_name": "YBR0510", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "YBR0510", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized glycosyl hydrolase YBR056W; 3.2.1.-", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR056W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;22984289;24374639;33481703;33491328;7597852;7813418", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ55", "ec_number_list": "", "go_molecular_function": "GO:0046557 glucan endo-1,6-beta-glucosidase activity;GO:0004338 glucan exo-1,3-beta-glucosidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0009251 glucan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38081-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38123-1", "uniprot_id": "SWD3_YEAST", "mass": 34754.0, "length": 315, "protein_name": "COMPASS component SWD3", "gene_name": "SWD3", "organism": "Yeast", "refseq_name": "Swd3p", "refseq_ac": "NP_009734", "gene_names_uniprotkb": "SWD3; CPS30; SAF35; YBR1237", "gene_names_refseq": "CPS30; SAF35; SWD3", "protein_names_uniprotkb": "COMPASS component SWD3; Complex proteins associated with SET1 protein SWD3; Set1C component SWD3", "protein_names_refseq": "Swd3p", "tax_id": 559292, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YBR175W); (R-SCE-9772755)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11687631;11742990;11752412;11805083;17322287;24374639;29071121;30100186;31922488;33491328;7813418", "class_list": "", "function": "The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation (PubMed:11742990, PubMed:11805083). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (PubMed:31922488). SWD3/CPS30 establishes COMPASS trimethylation activity and may also serve as the anchor point to properly tether and space the other subunits (PubMed:30100186)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQH0", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048188 Set1C/COMPASS complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0000723 telomere maintenance;GO:1903341 regulation of meiotic DNA double-strand break formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38123-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38167-1", "uniprot_id": "ECM21_YEAST", "mass": 123610.0, "length": 1117, "protein_name": "Protein ECM21", "gene_name": "ECM21", "organism": "Yeast", "refseq_name": "Ecm21p", "refseq_ac": "NP_009449", "gene_names_uniprotkb": "ECM21; YBL0814", "gene_names_refseq": "ART2; ECM21", "protein_names_uniprotkb": "Protein ECM21; Extracellular mutant protein 21", "protein_names_refseq": "Ecm21p", "tax_id": 559292, "disease": "stomach cancer (Disease Ontology:DOID:10534); Reye syndrome (Disease Ontology:DOID:14525); glaucoma (Disease Ontology:DOID:1686); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YBL101C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "12872131;14557538;14562095;14562106;15665377;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20190278;20702584;21126336;21177495;22106047;23749301;24374639;32597660;33229814;33481703;33491328;34965436;7502586;7813418;9335584", "class_list": "", "function": "May be involved in cell wall organization and biogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 69, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VPQ2", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009267 cellular response to starvation;GO:0033554 cellular response to stress;GO:0071230 cellular response to amino acid stimulus;GO:0070086 ubiquitin-dependent endocytosis;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P38167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38169-1", "uniprot_id": "KMO_YEAST", "mass": 52429.0, "length": 460, "protein_name": "Kynurenine 3-monooxygenase", "gene_name": "BNA4", "organism": "Yeast", "refseq_name": "kynurenine 3-monooxygenase", "refseq_ac": "NP_009454", "gene_names_uniprotkb": "BNA4; YBL0828", "gene_names_refseq": "BNA4", "protein_names_uniprotkb": "Kynurenine 3-monooxygenase; 1.14.13.9; Biosynthesis of nicotinic acid protein 4; Kynurenine 3-hydroxylase", "protein_names_refseq": "kynurenine 3-monooxygenase", "tax_id": 559292, "disease": "depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YBL098W); (R-SCE-71240)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12062417;14562095;14562106;14576278;15665377;15806102;16407407;17322287;19795423;19823750;23575632;24374639;29429898;33491328;7502586;7813418", "class_list": "", "function": "Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPQ7", "ec_number_list": "1.14.13.9", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004502 kynurenine 3-monooxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0070189 kynurenine metabolic process;GO:0019674 NAD+ metabolic process;GO:0019805 quinolinate biosynthetic process;GO:0043420 anthranilate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38169-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38170-1", "uniprot_id": "CND2_YEAST", "mass": 86216.0, "length": 754, "protein_name": "Condensin complex subunit 2", "gene_name": "BRN1", "organism": "Yeast", "refseq_name": "condensin subunit BRN1", "refseq_ac": "NP_009455", "gene_names_uniprotkb": "BRN1; YBL0830", "gene_names_refseq": "BRN1", "protein_names_uniprotkb": "Condensin complex subunit 2; Barren homolog; CAPH homolog", "protein_names_refseq": "condensin subunit BRN1", "tax_id": 559292, "disease": "primary autosomal recessive microcephaly 23 (Disease Ontology:DOID:0051034); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (sce:YBL097W); (R-SCE-2514853)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10749930;10749931;10811823;12748633;14562106;17322287;17563356;18407956;19481522;19779198;23749301;24374639;32597660;33481703;33491328;7502586;7813418", "class_list": "", "function": "Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPQ8;Q6Q5G8", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000796 condensin complex", "go_biological_process": "GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:0030261 chromosome condensation;GO:0000070 mitotic sister chromatid segregation;GO:0070058 tRNA gene clustering", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38170-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38174-1", "uniprot_id": "MAP2_YEAST", "mass": 47518.0, "length": 421, "protein_name": "Methionine aminopeptidase 2", "gene_name": "MAP2", "organism": "Yeast", "refseq_name": "methionine aminopeptidase", "refseq_ac": "NP_009462", "gene_names_uniprotkb": "MAP2; YBL0701", "gene_names_refseq": "MAP2", "protein_names_uniprotkb": "Methionine aminopeptidase 2; 3.4.11.18; MAP 2; MetAP 2; Peptidase M", "protein_names_refseq": "methionine aminopeptidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL091C); (R-SCE-2514859)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "11811952;12874831;14562095;14562106;15547949;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;24909858;32597660;33481703;33491328;7502586;7644482;7813418;8618900;9177176", "class_list": "", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Plays only a minor role in N-terminal methionine removal. Less efficient when the second residue is Val, Gly, Cys or Thr., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPR3;P89493", "ec_number_list": "3.4.11.18", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38174-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38198-1", "uniprot_id": "STU1_YEAST", "mass": 174177.0, "length": 1513, "protein_name": "Protein STU1", "gene_name": "STU1", "organism": "Yeast", "refseq_name": "Stu1p", "refseq_ac": "NP_009519", "gene_names_uniprotkb": "STU1; YBL0416", "gene_names_refseq": "STU1", "protein_names_uniprotkb": "Protein STU1; Suppressor of tubulin 1", "protein_names_refseq": "Stu1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL034C)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12058056;14562106;17287358;17563356;18407956;19779198;21177495;22031224;23749301;24374639;30516470;32597660;33229814;33481703;33491328;7806575;7813418;8091857", "class_list": "", "function": "Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for separation of the spindle poles during mitotic spindle formation. May cross-link overlapping antiparallel microtubules in the spindle midzone., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "D6VPW5", "ec_number_list": "", "go_molecular_function": "GO:0008017 microtubule binding;GO:0048487 beta-tubulin binding;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005815 microtubule organizing center;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0060172 astral microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P38198-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38199-1", "uniprot_id": "HEK2_YEAST", "mass": 41683.0, "length": 381, "protein_name": "Heterogeneous nuclear rnp K-like protein 2", "gene_name": "HEK2", "organism": "Yeast", "refseq_name": "Hek2p", "refseq_ac": "NP_009521", "gene_names_uniprotkb": "HEK2; KHD1; YBL0418", "gene_names_refseq": "HEK2; KHD1", "protein_names_uniprotkb": "Heterogeneous nuclear rnp K-like protein 2; KH domain-containing protein 1", "protein_names_refseq": "Hek2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL032W); (R-SCE-72203)", "pathway_count": 2, "publication_count": 27, "publication_id_list": "10331606;11739741;11867544;14562095;14562106;16010288;17287358;17322287;17330950;17563356;17588515;18067921;18407956;18805955;19779198;20702584;20953064;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;7725803;7813418", "class_list": "", "function": "RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Required for the asymmetric localization to the daughter cell nucleus of the ASH1 transcript, coding for a specific repressor of transcription. Overexpression inhibits translation of the ASH1 transcript. Involved in the stability of transcripts such as the MTL1 mRNA. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPW7;E9P8X5", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006417 regulation of translation;GO:0048255 mRNA stabilization;GO:0000723 telomere maintenance;GO:0006325 chromatin organization;GO:0070935 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P38199-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38205-1", "uniprot_id": "NCL1_YEAST", "mass": 77879.0, "length": 684, "protein_name": "Multisite-specific tRNA:(cytosine-C(5))-methyltransferase", "gene_name": "NCL1", "organism": "Yeast", "refseq_name": "tRNA (cytosine-C5-)-methyltransferase", "refseq_ac": "NP_009529", "gene_names_uniprotkb": "NCL1; TRM4; YBL0437", "gene_names_refseq": "NCL1; TRM4", "protein_names_uniprotkb": "Multisite-specific tRNA:(cytosine-C(5))-methyltransferase; 2.1.1.202; Multisite-specific tRNA:m5C-methyltransferase; tRNA (cytosine-5-)-methyltransferase NCL1; tRNA methyltransferase 4", "protein_names_refseq": "tRNA (cytosine-C5-)-methyltransferase", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder 5 (Disease Ontology:DOID:0081181)", "pathway": " (sce:YBL024W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10445884;14562106;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;30516470;32597660;33481703;33491328;7725803;7813418;9767141", "class_list": "", "function": "Methylates cytosine to m5C at several positions in different tRNAs and pre-tRNAs containing intron. Able to modify tRNAs at all four positions (34, 40, 48 and 49) at which m5C has been found in tRNAs. May be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPX6", "ec_number_list": "2.1.1.202", "go_molecular_function": "GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006400 tRNA modification;GO:0070301 cellular response to hydrogen peroxide;GO:0030488 tRNA methylation;GO:0002127 tRNA wobble base cytosine methylation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P38205-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38207-1", "uniprot_id": "APN2_YEAST", "mass": 59445.0, "length": 520, "protein_name": "DNA-(apurinic or apyrimidinic site) endonuclease 2", "gene_name": "APN2", "organism": "Yeast", "refseq_name": "DNA-(apurinic or apyrimidinic site) lyase APN2", "refseq_ac": "NP_009534", "gene_names_uniprotkb": "APN2; ETH1; YBL0443", "gene_names_refseq": "APN2; ETH1", "protein_names_uniprotkb": "DNA-(apurinic or apyrimidinic site) endonuclease 2; 3.1.11.2; AP endonuclease 2; Apurinic-apyrimidinic endonuclease 2", "protein_names_refseq": "DNA-(apurinic or apyrimidinic site) lyase APN2", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL019W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10806210;14562106;17322287;24374639;33491328;7813418;9765213", "class_list": "", "function": "DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPY1;E9P926", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008081 phosphoric diester hydrolase activity;GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38207-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38208-1", "uniprot_id": "POP8_YEAST", "mass": 15512.0, "length": 133, "protein_name": "Ribonucleases P/MRP protein subunit POP8", "gene_name": "POP8", "organism": "Yeast", "refseq_name": "ribonuclease P", "refseq_ac": "NP_009535", "gene_names_uniprotkb": "POP8; YBL0301", "gene_names_refseq": "POP8", "protein_names_uniprotkb": "Ribonucleases P/MRP protein subunit POP8; 3.1.26.5; RNA-processing protein POP8; RNases P/MRP 15.5 kDa subunit", "protein_names_refseq": "ribonuclease P", "tax_id": 559292, "disease": "", "pathway": " (sce:YBL018C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;14690591;15637077;24374639;33491328;7813418;9620854", "class_list": "", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPY2", "ec_number_list": "", "go_molecular_function": "GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0008033 tRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0001682 tRNA 5'-leader removal;GO:0034965 intronic box C/D snoRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38211-1", "uniprot_id": "GPI18_YEAST", "mass": 50759.0, "length": 433, "protein_name": "GPI mannosyltransferase 2", "gene_name": "GPI18", "organism": "Yeast", "refseq_name": "GPI-anchor transamidase GPI18", "refseq_ac": "NP_009558", "gene_names_uniprotkb": "GPI18; YBR0110", "gene_names_refseq": "GPI18", "protein_names_uniprotkb": "GPI mannosyltransferase 2; 2.4.1.-; GPI mannosyltransferase II; GPI-MT-II; Glycosylphosphatidylinositol-anchor biosynthesis protein 18", "protein_names_refseq": "GPI-anchor transamidase GPI18", "tax_id": 559292, "disease": "hyperphosphatasia with impaired intellectual development syndrome 1 (Disease Ontology:DOID:0070433)", "pathway": " (sce:YBR004C); (R-SCE-162710)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15623507;15720390;17615295;24374639;7813418", "class_list": "", "function": "Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ05;P89496", "ec_number_list": "2.4.1.-", "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0120563 dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase activity", "go_cellular_component": "GO:0031501 mannosyltransferase complex;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P38211-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38212-1", "uniprot_id": "RCR1_YEAST", "mass": 23887.0, "length": 213, "protein_name": "Protein RCR1", "gene_name": "RCR1", "organism": "Yeast", "refseq_name": "Rcr1p", "refseq_ac": "NP_009559", "gene_names_uniprotkb": "RCR1; YBR0111", "gene_names_refseq": "RCR1; SSH6", "protein_names_uniprotkb": "Protein RCR1; Resistance to Congo red protein 1", "protein_names_refseq": "Rcr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR005W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15590673;17213653;17322287;18407956;23749301;24374639;32597660;33481703;33491328;7813418", "class_list": "", "function": "Regulates chitin deposition in the cell wall., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ06", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0016192 vesicle-mediated transport;GO:0006033 chitin localization;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38212-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38221-1", "uniprot_id": "CDS1_YEAST", "mass": 51823.0, "length": 457, "protein_name": "Phosphatidate cytidylyltransferase", "gene_name": "CDS1", "organism": "Yeast", "refseq_name": "phosphatidate cytidylyltransferase", "refseq_ac": "NP_009585", "gene_names_uniprotkb": "CDS1; CDG1; YBR0313", "gene_names_refseq": "CDG1; CDS1", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase; 2.7.7.41; CDP-DAG synthase; CDP-DG synthase; CDP-diacylglycerol synthase; CDP-diglyceride pyrophosphorylase; CDP-diglyceride synthase; CDS; CTP:phosphatidate cytidylyltransferase", "protein_names_refseq": "phosphatidate cytidylyltransferase", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YBR029C); (R-SCE-1483148); (R-SCE-1483226)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "17322287;21126336;2163397;23623749;23749301;24374639;2822695;32597660;33481703;33491328;34965436;7813418;8091864;8557688;8910557", "class_list": "", "function": "Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ30", "ec_number_list": "2.7.7.41", "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0070319 Golgi to plasma membrane transport vesicle", "go_biological_process": "GO:0046488 phosphatidylinositol metabolic process;GO:0140042 lipid droplet formation;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0006658 phosphatidylserine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38221-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38225-1", "uniprot_id": "FAT1_YEAST", "mass": 77141.0, "length": 669, "protein_name": "Very long-chain fatty acid transport protein", "gene_name": "FAT1", "organism": "Yeast", "refseq_name": "long-chain fatty acid transporter FAT1", "refseq_ac": "NP_009597", "gene_names_uniprotkb": "FAT1; YBR0411", "gene_names_refseq": "FAT1", "protein_names_uniprotkb": "Very long-chain fatty acid transport protein; 6.2.1.-; VLCS; Very-long-chain acyl-CoA synthetase", "protein_names_refseq": "long-chain fatty acid transporter FAT1", "tax_id": 559292, "disease": "restrictive dermopathy (Disease Ontology:DOID:0060762); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); glucose intolerance (Disease Ontology:DOID:10603); familial hyperlipidemia (Disease Ontology:DOID:1168); hyperinsulinism (Disease Ontology:DOID:2018); myocardial infarction (Disease Ontology:DOID:5844); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YBR041W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10515935;11330068;12052836;12601005;14562106;15699031;17679730;21820081;22493507;24374639;24868093;7813418;9079682;9660783;9988704", "class_list": "", "function": "Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:11330068, PubMed:12052836, PubMed:12601005, PubMed:9079682, PubMed:9988704). The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities (PubMed:12052836). Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane (PubMed:22493507)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ41;O60021;Q86ZS3", "ec_number_list": "6.2.1.-", "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0044539 long-chain fatty acid import into cell;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38225-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38228-1", "uniprot_id": "TCM62_YEAST", "mass": 64252.0, "length": 572, "protein_name": "Mitochondrial chaperone TCM62", "gene_name": "TCM62", "organism": "Yeast", "refseq_name": "Tcm62p", "refseq_ac": "NP_009600", "gene_names_uniprotkb": "TCM62; YBR0414", "gene_names_refseq": "TCM62", "protein_names_uniprotkb": "Mitochondrial chaperone TCM62", "protein_names_refseq": "Tcm62p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR044C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10745098;14576278;24374639;7813418;9822678", "class_list": "", "function": "Chaperone. Required for the assembly of succinate dehydrogenase subunits. Ensures mitochondrial gene expression at elevated temperatures and prevents heat-aggregation of the ribosomal subunit VAR1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ44;Q9Y793", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0006457 protein folding;GO:0007005 mitochondrion organization;GO:0042026 protein refolding;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P38228-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38236-1", "uniprot_id": "FL2D_YEAST", "mass": 41433.0, "length": 366, "protein_name": "Protein MUM2", "gene_name": "MUM2", "organism": "Yeast", "refseq_name": "Mum2p", "refseq_ac": "NP_009613", "gene_names_uniprotkb": "MUM2; YBR0514", "gene_names_refseq": "MUM2", "protein_names_uniprotkb": "Protein MUM2; Muddled meiosis protein 2", "protein_names_refseq": "Mum2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR057C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12586695;14562106;19795423;19823750;22685417;24269006;24374639;33229814;36930734;7597852;7813418", "class_list": "", "function": "Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ56", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051321 meiotic cell cycle;GO:0006279 premeiotic DNA replication;GO:0030435 sporulation resulting in formation of a cellular spore;GO:2000221 negative regulation of pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38236-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38237-1", "uniprot_id": "UBP14_YEAST", "mass": 88630.0, "length": 781, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 14", "gene_name": "UBP14", "organism": "Yeast", "refseq_name": "ubiquitin-specific protease UBP14", "refseq_ac": "NP_009614", "gene_names_uniprotkb": "UBP14; GID6; YBR0515", "gene_names_refseq": "GID6; UBP14", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 14; 3.4.19.12; Deubiquitinating enzyme 14; Glucose-induced degradation protein 6; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14", "protein_names_refseq": "ubiquitin-specific protease UBP14", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR058C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12686616;12748633;14562095;14562106;15096053;24374639;33481703;33491328;7597852;7813418;9305625", "class_list": "", "function": "Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:12686616). Accelerates proteasomal breakdown of ubiquitinated proteins as it disassembles free ubiquitin chains that would compete with ubiquitinated proteins to bind to the proteasome (PubMed:9305625)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ57", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031647 regulation of protein stability;GO:0045721 negative regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38237-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38238-1", "uniprot_id": "TRM7_YEAST", "mass": 34701.0, "length": 310, "protein_name": "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase", "gene_name": "TRM7", "organism": "Yeast", "refseq_name": "tRNA methyltransferase TRM7", "refseq_ac": "NP_009617", "gene_names_uniprotkb": "TRM7; YBR0527", "gene_names_refseq": "TRM7", "protein_names_uniprotkb": "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; 2'-O-ribose RNA methyltransferase TRM7; 2.1.1.205; tRNA methylase 7", "protein_names_refseq": "tRNA methyltransferase TRM7", "tax_id": 559292, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 9 (Disease Ontology:DOID:0112034)", "pathway": " (sce:YBR061C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11927565;14562095;14562106;22814378;22912484;24374639;25404562;26310293;29596413;30516470;31586407;32053677;33491328;7813418", "class_list": "", "function": "Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:11927565, PubMed:22912484, PubMed:26310293, PubMed:31586407). Requisite for faithful cytoplasmic translation (By similarity). Requires TRM732 for methylation of the cytidine at position 32 of the anticodon loop of substrate tRNAs (PubMed:22912484). Requires RTT10/TRM734 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:22912484). May modify position 32 in tRNA(Leu(UAA)), tRNA(Phe(GAA)), and tRNA(Trp(CCA)) and position 34 in tRNA(Leu(UAA)), tRNA(Phe(GAA)) and tRNA(Trp(CCA)) (PubMed:22912484). Methylation of tRNA(Phe) at position 34 plays a role in the oxidative stress-response as it may promote translation of UUC over UUU, and UUC-containing genes are enriched for oxidative stress-responsive processes (PubMed:32053677)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ61", "ec_number_list": "2.1.1.205", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0016423 tRNA (guanine) methyltransferase activity;GO:0106050 tRNA 2'-O-methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0106340 tRNA (guanosine(34)-2'-O)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0030488 tRNA methylation;GO:0002181 cytoplasmic translation;GO:0002130 wobble position ribose methylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38238-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38244-1", "uniprot_id": "PFF1_YEAST", "mass": 111035.0, "length": 976, "protein_name": "Vacuolar membrane protease", "gene_name": "PFF1", "organism": "Yeast", "refseq_name": "Pff1p", "refseq_ac": "NP_009630", "gene_names_uniprotkb": "PFF1; YBR0718; YBR0719; YBR075W", "gene_names_refseq": "PFF1; YBR075W", "protein_names_uniprotkb": "Vacuolar membrane protease; 3.4.-.-; FXNA-related family protease 1", "protein_names_refseq": "Pff1p", "tax_id": 559292, "disease": "chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (sce:YBR074W)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12844361;17330950;18407956;19684113;19779198;20702584;21126336;21177495;22218487;22814378;23679341;23749301;24374639;32597660;33481703;33491328;7813418;7985423", "class_list": "", "function": "May be involved in vacuolar sorting and osmoregulation., [UniProtKB, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ74;P38245;Q86ZS2", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008235 metalloexopeptidase activity", "go_cellular_component": "GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P38244-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38247-1", "uniprot_id": "SLM4_YEAST", "mass": 18354.0, "length": 162, "protein_name": "Protein SLM4", "gene_name": "SLM4", "organism": "Yeast", "refseq_name": "Slm4p", "refseq_ac": "NP_009633", "gene_names_uniprotkb": "SLM4; EGO3; GSE1; YBR0723", "gene_names_refseq": "EGO3; GSE1; NIR1; SLM4", "protein_names_uniprotkb": "Protein SLM4; EGO complex subunit 3; GSE complex subunit 1", "protein_names_refseq": "Slm4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR077C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;15989961;16732272;20655927;24374639;29698392;32801125;7813418;7985423", "class_list": "", "function": "Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272). Component of the EGO complex, a complex involved in the regulation of microautophagy (PubMed:15989961)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ76", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0071986 Ragulator complex;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport;GO:0032008 positive regulation of TOR signaling;GO:0032456 endocytic recycling;GO:0016237 microautophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38247-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38248-1", "uniprot_id": "ECM33_YEAST", "mass": 43769.0, "length": 429, "protein_name": "Cell wall protein ECM33", "gene_name": "ECM33", "organism": "Yeast", "refseq_name": "Ecm33p", "refseq_ac": "NP_009634", "gene_names_uniprotkb": "ECM33; YBR0727", "gene_names_refseq": "ECM33", "protein_names_uniprotkb": "Cell wall protein ECM33; Extracellular mutant protein 33", "protein_names_refseq": "Ecm33p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR078W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10383953;10734188;11957109;12583915;15583168;15781460;17617218;17761666;18434410;21126336;23749301;24374639;33481703;33491328;7813418;7985423;9335584", "class_list": "", "function": "Required for proper cell wall integrity and for the correct assembly of the mannoprotein outer layer of the cell wall. Important for apical bud growth., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ77;P89498", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38248-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38250-1", "uniprot_id": "IST2_YEAST", "mass": 105854.0, "length": 946, "protein_name": "Increased sodium tolerance protein 2", "gene_name": "IST2", "organism": "Yeast", "refseq_name": "Ist2p", "refseq_ac": "NP_009643", "gene_names_uniprotkb": "IST2; YBR0809", "gene_names_refseq": "IST2", "protein_names_uniprotkb": "Increased sodium tolerance protein 2", "protein_names_refseq": "Ist2p", "tax_id": 559292, "disease": "autosomal recessive spinocerebellar ataxia 10 (Disease Ontology:DOID:0050999)", "pathway": " (sce:YBR086C); (R-SCE-2672351); (R-SCE-6798695); (R-SCE-9769739); (R-SCE-9769743)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "11030653;11875433;15665377;15701790;16847258;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;7813418;7900426", "class_list": "", "function": "May be involved in ion homeostasis together with BTN1 or BTN2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 43, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQ87;P89499", "ec_number_list": "", "go_molecular_function": "GO:0008289 lipid binding;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0032541 cortical endoplasmic reticulum;GO:0033101 cellular bud membrane", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization;GO:0072659 protein localization to plasma membrane;GO:0045332 phospholipid translocation;GO:0060304 regulation of phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38250-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38262-1", "uniprot_id": "SIF2_YEAST", "mass": 59161.0, "length": 535, "protein_name": "SIR4-interacting protein SIF2", "gene_name": "SIF2", "organism": "Yeast", "refseq_name": "Sif2p", "refseq_ac": "NP_009661", "gene_names_uniprotkb": "SIF2; EMB1; YBR0832", "gene_names_refseq": "EMB1; SIF2", "protein_names_uniprotkb": "SIR4-interacting protein SIF2", "protein_names_refseq": "Sif2p", "tax_id": 559292, "disease": "sensory system disease (Disease Ontology:DOID:0050155); autosomal dominant intellectual developmental disorder 41 (Disease Ontology:DOID:0070071); Pierpont syndrome (Disease Ontology:DOID:0081362); Y-linked deafness 2 (Disease Ontology:DOID:0111758); congenital nongoitrous hypothyroidism 8 (Disease Ontology:DOID:0111837)", "pathway": " (sce:YBR103W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11711434;14562106;16051270;17322287;17330950;18407956;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;30516470;33481703;33491328;7813418;7900426;9651685", "class_list": "", "function": "Antagonizes telomeric silencing in yeast. May recruit SIR4 to non-telomeric sites or repression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQA2", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0034967 Set3 complex;GO:0070210 Rpd3L-Expanded complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006974 DNA damage response;GO:0006325 chromatin organization;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38262-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38263-1", "uniprot_id": "GID4_YEAST", "mass": 41245.0, "length": 362, "protein_name": "GID complex substrate-recognition subunit 4", "gene_name": "VID24", "organism": "Yeast", "refseq_name": "glucose-induced degradation complex subunit VID24", "refseq_ac": "NP_009663", "gene_names_uniprotkb": "VID24; GID4; YBR0834", "gene_names_refseq": "GID4; VID24", "protein_names_uniprotkb": "GID complex substrate-recognition subunit 4; Glucose-induced degradation protein 4; Vacuolar import and degradation protein 24", "protein_names_refseq": "glucose-induced degradation complex subunit VID24", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR105C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "12686616;14562106;16872538;17322287;18407956;18508925;22106047;22645139;23749301;24374639;28126757;31708416;32513738;32597660;33481703;33491328;33905682;35650207;7813418;7900426;9508768", "class_list": "", "function": "Substrate-recognition component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations (PubMed:12686616, PubMed:18508925, PubMed:28126757, PubMed:31708416). Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:31708416, PubMed:9508768). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes, probably by targeting FBP1-containing vesicles to the vacuole, but is not required for FBP1 sequestration in cytoplasmic vesicles (PubMed:12686616, PubMed:22645139, PubMed:28126757, PubMed:9508768). Specific for substrates with an N-terminal Pro (Pro/N-degron), including FBP1, ICL1 and MDH2. Has high affinity for the N-terminal sequence Pro-Thr-Leu-Val, and can bind peptides with an N-terminal sequence of the type Pro-[Gly,Ala,Ser,Thr,Asp,Asn,Tyr,His]-[Ala,Val,Leu,Ile,Lys,Arg]-[Val,Cys,Pro,Leu,Ile,Trp] (PubMed:28126757). Also recognizes nonproline N-terminal residues and targets an Ile-Gly-Lys-Trp-bearing protein for rapid degradation (PubMed:32513738)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQA4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle;GO:0005773 vacuole;GO:0034657 GID complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045721 negative regulation of gluconeogenesis;GO:0007039 protein catabolic process in the vacuole;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P38263-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38265-1", "uniprot_id": "CENPL_YEAST", "mass": 28066.0, "length": 245, "protein_name": "Inner kinetochore subunit IML3", "gene_name": "IML3", "organism": "Yeast", "refseq_name": "Iml3p", "refseq_ac": "NP_009665", "gene_names_uniprotkb": "IML3; MCM19; YBR0836", "gene_names_refseq": "IML3; MCM19", "protein_names_uniprotkb": "Inner kinetochore subunit IML3; CENP-L homolog; Constitutive centromere-associated network protein IML3; Increased minichromosome loss protein 3; Minichromosome maintenance protein 19", "protein_names_refseq": "Iml3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR107C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11361335;12408861;12589047;14562095;14562106;15241623;22561346;24075991;24311582;24374639;7813418;7900426", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQA6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0034087 establishment of mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38265-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38270-1", "uniprot_id": "ATG14_YEAST", "mass": 40454.0, "length": 344, "protein_name": "Autophagy-related protein 14", "gene_name": "ATG14", "organism": "Yeast", "refseq_name": "Atg14p", "refseq_ac": "NP_009686", "gene_names_uniprotkb": "ATG14; APG14; CVT12; YBR1003", "gene_names_refseq": "APG14; ATG14; CVT12", "protein_names_uniprotkb": "Autophagy-related protein 14; Cytoplasm to vacuole targeting protein 12", "protein_names_refseq": "Atg14p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR128C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10547367;11096087;11157979;11382761;11689437;15004240;16267277;16421251;16565503;17322287;18077553;18829864;19445518;20855505;21703229;22718752;23129774;24165940;24374639;2521486;7813418;8091856;8224160;8663607;9712845", "class_list": "", "function": "Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQC5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site;GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I;GO:0000329 fungal-type vacuole membrane;GO:0120095 vacuole-isolation membrane contact site", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0034727 piecemeal microautophagy of the nucleus;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38270-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38273-1", "uniprot_id": "CCZ1_YEAST", "mass": 80732.0, "length": 704, "protein_name": "Vacuolar fusion protein CCZ1", "gene_name": "CCZ1", "organism": "Yeast", "refseq_name": "Ccz1p", "refseq_ac": "NP_009689", "gene_names_uniprotkb": "CCZ1; AUT11; CVT16; YBR1006", "gene_names_refseq": "CCZ1; CVT16", "protein_names_uniprotkb": "Vacuolar fusion protein CCZ1; Autophagy-related protein 11; Calcium-caffeine-zinc sensitivity protein 1; Ccz1p; Cytoplasm to vacuole targeting protein 16", "protein_names_refseq": "Ccz1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR131W); (R-SCE-8876198)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10407278;11069774;11590240;12208507;12364329;14562095;14562106;14662743;15184059;15721293;17322287;20797862;23749301;24374639;32391792;32597660;33481703;33491328;37463208;7813418;8091856", "class_list": "", "function": "In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking (PubMed:10407278, PubMed:11069774, PubMed:11590240, PubMed:12208507, PubMed:12364329, PubMed:14662743, PubMed:15184059, PubMed:15721293, PubMed:32391792, PubMed:37463208). The MON1-CCZ1 complex is recruited to membranes enriched in charged lipids, particularly phosphatidylinositol 3-phosphate (PtdIns3P), by GTP-associated small GTPase RAB5 homologs (YPT10, YPT52, YPT53 and VPS21) (PubMed:32391792). The MON1-CCZ1 complex recruits GDP-associated small GTPase YPT7 to membranes and acts as a guanine nucleotide-exchange factor (GEF), promoting nucleotide exchange on YPT7 and triggering endosomal maturation by recruiting downstream effectors such as components of the HOPS tethering complex (PubMed:20797862, PubMed:32391792)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQC8", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0001786 phosphatidylserine binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0005770 late endosome;GO:0005774 vacuolar membrane;GO:0032585 multivesicular body membrane", "go_biological_process": "GO:0007034 vacuolar transport;GO:0097352 autophagosome maturation;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P38273-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38285-1", "uniprot_id": "AMN1_YEAST", "mass": 62686.0, "length": 549, "protein_name": "Antagonist of mitotic exit network protein 1", "gene_name": "AMN1", "organism": "Yeast", "refseq_name": "Amn1p", "refseq_ac": "NP_009716", "gene_names_uniprotkb": "AMN1; CST13; ICS4; YBR1208", "gene_names_refseq": "AMN1; CST13; ICS4", "protein_names_uniprotkb": "Antagonist of mitotic exit network protein 1; Chromosome stability protein 13; Increased copper-sensitivity protein 4", "protein_names_refseq": "Amn1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR158W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10454593;10628851;11309124;12628189;12897782;14562095;14562106;14690591;16079183;17322287;23749301;24374639;33229814;33481703;33491328;7813418", "class_list": "", "function": "Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints. Acts in the daughter cell to inhibit the mitotic exit pathway once MEN has executed its function. Through its binding ability to TEM1, interferes with the TEM1-CDC5 association, required for CDC5 kinase activation and MEN activation. Required for daughter cell separation and chromosome stability. Involved in copper sensitivity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VQF3", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005933 cellular bud", "go_biological_process": "GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0001100 negative regulation of exit from mitosis;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0032984 protein-containing complex disassembly", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38285-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38286-1", "uniprot_id": "MKAR_YEAST", "mass": 38708.0, "length": 347, "protein_name": "Very-long-chain 3-oxoacyl-CoA reductase", "gene_name": "IFA38", "organism": "Yeast", "refseq_name": "ketoreductase", "refseq_ac": "NP_009717", "gene_names_uniprotkb": "IFA38; YBR1209", "gene_names_refseq": "IFA38", "protein_names_uniprotkb": "Very-long-chain 3-oxoacyl-CoA reductase; 1.1.1.330; 3-ketoacyl-CoA reductase; 3-ketoreductase; KAR; Microsomal beta-keto-reductase", "protein_names_refseq": "ketoreductase", "tax_id": 559292, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); 17-beta hydroxysteroid dehydrogenase 3 deficiency (Disease Ontology:DOID:0112248); Alzheimer's disease (Disease Ontology:DOID:10652); gynecomastia (Disease Ontology:DOID:12698); cancer (Disease Ontology:DOID:162); disorder of sexual development (Disease Ontology:DOID:1923); pseudohermaphroditism (Disease Ontology:DOID:3765); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YBR159W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11792704;12087109;12684876;14562095;14562106;17322287;17719544;18407956;22814378;23263984;24374639;25003994;33491328;7813418", "class_list": "", "function": "Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQF4", "ec_number_list": "1.1.1.330", "go_molecular_function": "GO:0045703 ketoreductase activity;GO:0141040 very-long-chain 3-oxoacyl-CoA reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38286-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38289-1", "uniprot_id": "EXO5_YEAST", "mass": 67570.0, "length": 585, "protein_name": "Exonuclease V, mitochondrial", "gene_name": "EXO5", "organism": "Yeast", "refseq_name": "Exo5p", "refseq_ac": "NP_009722", "gene_names_uniprotkb": "EXO5; DEM1; YBR1215", "gene_names_refseq": "DEM1; EXO5", "protein_names_uniprotkb": "Exonuclease V, mitochondrial; 3.1.-.-; Defects in morphology protein 1; Exo V", "protein_names_refseq": "Exo5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR163W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10628851;14562095;14562106;20086101;24374639;3286646;7813418", "class_list": "", "function": "Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQF9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38289-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38291-1", "uniprot_id": "POP7_YEAST", "mass": 15814.0, "length": 140, "protein_name": "Ribonucleases P/MRP protein subunit POP7", "gene_name": "POP7", "organism": "Yeast", "refseq_name": "ribonuclease P/MRP protein subunit POP7", "refseq_ac": "NP_009726", "gene_names_uniprotkb": "POP7; RPP2; YBR1219", "gene_names_refseq": "POP7; RPP2", "protein_names_uniprotkb": "Ribonucleases P/MRP protein subunit POP7; 3.1.26.5; RNA-processing protein POP7; RNases P/MRP 15.8 kDa subunit", "protein_names_refseq": "ribonuclease P/MRP protein subunit POP7", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR167C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;15637077;17322287;18407956;24374639;33491328;7813418;9618478;9620854", "class_list": "", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQG3;E9P8X7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0005697 telomerase holoenzyme complex;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38291-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38295-1", "uniprot_id": "MCFS2_YEAST", "mass": 51255.0, "length": 451, "protein_name": "Medium-chain fatty acid ethyl ester synthase/esterase 2", "gene_name": "EHT1", "organism": "Yeast", "refseq_name": "medium-chain fatty acid ethyl ester synthase/esterase", "refseq_ac": "NP_009736", "gene_names_uniprotkb": "EHT1; YBR1239", "gene_names_refseq": "EHT1", "protein_names_uniprotkb": "Medium-chain fatty acid ethyl ester synthase/esterase 2; 2.3.1.84; 3.1.1.-; Alcohol O-acetyltransferase; Ethanol hexanoyl transferase 1", "protein_names_refseq": "medium-chain fatty acid ethyl ester synthase/esterase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR177C); (R-SCE-1483191)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562106;16361250;21126336;22106047;24374639;33481703;33491328;7813418", "class_list": "", "function": "Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQH2", "ec_number_list": "3.1.1.-;2.3.1.84;3.1.2.20;3.1.1.23", "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0017171 serine hydrolase activity;GO:0008126 acetylesterase activity;GO:0034338 short-chain carboxylesterase activity;GO:0004026 alcohol O-acetyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005811 lipid droplet", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0051793 medium-chain fatty acid catabolic process;GO:0051792 medium-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38295-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38298-1", "uniprot_id": "YPC1_YEAST", "mass": 36420.0, "length": 316, "protein_name": "Alkaline ceramidase YPC1", "gene_name": "YPC1", "organism": "Yeast", "refseq_name": "phytoceramidase", "refseq_ac": "NP_009742", "gene_names_uniprotkb": "YPC1; YBR1305", "gene_names_refseq": "YPC1", "protein_names_uniprotkb": "Alkaline ceramidase YPC1; 3.5.1.-; Acyl-CoA-independent ceramide synthase", "protein_names_refseq": "phytoceramidase", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); leukodystrophy (Disease Ontology:DOID:10579); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YBR183W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10702247;10900202;11694577;16847258;23445175;24374639;24866405;7813418;7871891", "class_list": "", "function": "Alkaline ceramidase that hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Also has reverse activity as acyl-CoA-independent ceramide synthase, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide (PubMed:10702247, PubMed:10900202, PubMed:11694577, PubMed:24866405). Preferentially uses very long chain fatty acids (C-24 and C-26) in vivo compared to C-16 in vitro (PubMed:24866405)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQH8", "ec_number_list": "3.5.1.-", "go_molecular_function": "GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0050291 sphingosine N-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0046514 ceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38298-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38301-1", "uniprot_id": "GDT1_YEAST", "mass": 30341.0, "length": 280, "protein_name": "Divalent cation/proton antiporter GDT1", "gene_name": "GDT1", "organism": "Yeast", "refseq_name": "putative ribosome biosynthesis protein GDT1", "refseq_ac": "NP_009746", "gene_names_uniprotkb": "GDT1; YBR1310", "gene_names_refseq": "GDT1", "protein_names_uniprotkb": "Divalent cation/proton antiporter GDT1; GCR1-dependent translation factor 1", "protein_names_refseq": "putative ribosome biosynthesis protein GDT1", "tax_id": 559292, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571); congenital disorder of glycosylation type IIk (Disease Ontology:DOID:0070263)", "pathway": " (sce:YBR187W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;16847258;17124610;23569283;23575229;24374639;27008884;27075443;36963491;7813418;7871891", "class_list": "", "function": "Divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway. The transport stoichiometry remains to be elucidated., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQI2;E9PAD4;Q6Q545", "ec_number_list": "", "go_molecular_function": "GO:0015085 calcium ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0015369 calcium:proton antiporter activity;GO:0010486 manganese:proton antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0030026 intracellular manganese ion homeostasis;GO:0032468 Golgi calcium ion homeostasis;GO:0032472 Golgi calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38301-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38313-1", "uniprot_id": "CENPU_YEAST", "mass": 37462.0, "length": 324, "protein_name": "Inner kinetochore subunit AME1", "gene_name": "AME1", "organism": "Yeast", "refseq_name": "Ame1p", "refseq_ac": "NP_009770", "gene_names_uniprotkb": "AME1; ARP100; YBR1458", "gene_names_refseq": "AME1; ARP100", "protein_names_uniprotkb": "Inner kinetochore subunit AME1; Associated with microtubules and essential protein 1; CENP-U homolog; Constitutive centromere-associated network protein AME1", "protein_names_refseq": "Ame1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR211C)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "12408861;14562095;14562106;14633972;14690591;15665377;17322287;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;21126336;21177495;22561346;23749301;24374639;29046335;32597660;33229814;33481703;33491328;34308839;7813418", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VQK7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000776 kinetochore;GO:0005816 spindle pole body;GO:0000817 COMA complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0051321 meiotic cell cycle;GO:0034501 protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P38313-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38316-1", "uniprot_id": "ATG12_YEAST", "mass": 21106.0, "length": 186, "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "ATG12", "organism": "Yeast", "refseq_name": "Atg12p", "refseq_ac": "NP_009776", "gene_names_uniprotkb": "ATG12; APG12; YBR1506", "gene_names_refseq": "APG12; ATG12", "protein_names_uniprotkb": "Ubiquitin-like protein ATG12; Autophagy-related protein 12", "protein_names_refseq": "Atg12p", "tax_id": 559292, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547)", "pathway": " (sce:YBR217W); (R-SCE-1632852); (R-SCE-8934903)", "pathway_count": 3, "publication_count": 32, "publication_id_list": "10233150;10508157;10712513;11139573;11149920;11689437;11897782;12965207;14536056;16874032;16901900;17295840;17322287;17404498;17986448;18407956;18421155;18701704;18725539;18971623;20065092;21703229;22768199;23064152;23238393;23549786;24374639;32597660;35363116;7813418;8224160;9759731", "class_list": "", "function": "Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQL3", "ec_number_list": "", "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0031386 protein tag activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005829 cytosol;GO:0034045 phagophore assembly site membrane;GO:0034274 Atg12-Atg5-Atg16 complex", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0016236 macroautophagy;GO:0061739 protein lipidation involved in autophagosome assembly;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P38316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38319-1", "uniprot_id": "TYDP1_YEAST", "mass": 62333.0, "length": 544, "protein_name": "Tyrosyl-DNA phosphodiesterase 1", "gene_name": "TDP1", "organism": "Yeast", "refseq_name": "tyrosyl-DNA phosphodiesterase 1", "refseq_ac": "NP_009782", "gene_names_uniprotkb": "TDP1; YBR1520", "gene_names_refseq": "TDP1", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 1; 3.1.4.-; Tyr-DNA phosphodiesterase 1", "protein_names_refseq": "tyrosyl-DNA phosphodiesterase 1", "tax_id": 559292, "disease": "spinocerebellar ataxia with axonal neuropathy 1 (Disease Ontology:DOID:0090115)", "pathway": " (sce:YBR223C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10521354;12206772;14562106;16751265;17707402;24374639;33481703;33491328;7813418", "class_list": "", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Also cleaves 5' phosphotyrosyl adducts resulting from dead-end complexes between DNA and the active site tyrosine of topoisomerase II. Contributes to DNA repair after radiation damage. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQM0", "ec_number_list": "", "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0004527 exonuclease activity;GO:0003697 single-stranded DNA binding;GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity;GO:0070260 5'-tyrosyl-DNA phosphodiesterase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38319-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38323-1", "uniprot_id": "CLPX_YEAST", "mass": 57946.0, "length": 520, "protein_name": "ATP-dependent clpX-like chaperone, mitochondrial", "gene_name": "MCX1", "organism": "Yeast", "refseq_name": "Mcx1p", "refseq_ac": "NP_009786", "gene_names_uniprotkb": "MCX1; YBR1524", "gene_names_refseq": "MCX1", "protein_names_uniprotkb": "ATP-dependent clpX-like chaperone, mitochondrial; ATP-dependent unfoldase ClpX; mtClpX", "protein_names_refseq": "Mcx1p", "tax_id": 559292, "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270)", "pathway": " (sce:YBR227C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;21126336;24374639;25957689;7813418;9827555", "class_list": "", "function": "ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase (HEM1), thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Up-regulates heme biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQM2", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process;GO:0042026 protein refolding;GO:0030150 protein import into mitochondrial matrix;GO:1904287 positive regulation of protein-pyridoxal-5-phosphate linkage", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38323-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38329-1", "uniprot_id": "VHC1_YEAST", "mass": 123999.0, "length": 1120, "protein_name": "Vacuolar cation-chloride cotransporter 1", "gene_name": "VHC1", "organism": "Yeast", "refseq_name": "Vhc1p", "refseq_ac": "NP_009794", "gene_names_uniprotkb": "VHC1; YBR1601", "gene_names_refseq": "VHC1", "protein_names_uniprotkb": "Vacuolar cation-chloride cotransporter 1; Vacuolar homolog of CCC family protein 1", "protein_names_refseq": "Vhc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR235W); (R-SCE-426117)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "11875433;16847258;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21177495;23022132;23749301;24374639;32597660;33481703;33491328;34965436;7813418;8526903", "class_list": "", "function": "Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQN1", "ec_number_list": "", "go_molecular_function": "GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0005774 vacuolar membrane;GO:0000329 fungal-type vacuole membrane;GO:1990816 vacuole-mitochondrion membrane contact site", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:0055064 chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P38329-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38336-1", "uniprot_id": "POP4_YEAST", "mass": 32881.0, "length": 279, "protein_name": "RNases MRP/P 32.9 kDa subunit", "gene_name": "POP4", "organism": "Yeast", "refseq_name": "RNase P/RNase MRP complex subunit", "refseq_ac": "NP_009816", "gene_names_uniprotkb": "POP4; YBR1725", "gene_names_refseq": "POP4", "protein_names_uniprotkb": "RNases MRP/P 32.9 kDa subunit; RNA-processing protein POP4", "protein_names_refseq": "RNase P/RNase MRP complex subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR257W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14690591;15637077;18407956;20702584;23749301;24374639;33491328;7813418;8465606;9085845;9620854", "class_list": "", "function": "Required for 5.8S rRNA and tRNA processing; associated with RNase MRP and RNase P., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQQ4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0033204 ribonuclease P RNA binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0000172 ribonuclease MRP complex;GO:0030677 ribonuclease P complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38336-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38337-1", "uniprot_id": "SHG1_YEAST", "mass": 16429.0, "length": 142, "protein_name": "COMPASS component SHG1", "gene_name": "SHG1", "organism": "Yeast", "refseq_name": "Shg1p", "refseq_ac": "NP_009817", "gene_names_uniprotkb": "SHG1; CPS15; YBR1726", "gene_names_refseq": "CPS15; SHG1", "protein_names_uniprotkb": "COMPASS component SHG1; Complex proteins associated with SET1 protein SHG1; Set1C component SHG1", "protein_names_refseq": "Shg1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR258C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11687631;11742990;11805083;14562106;17322287;19684113;22814378;24374639;29071121;33481703;7813418;8465606", "class_list": "", "function": "The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQQ5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0048188 Set1C/COMPASS complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38337-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38339-1", "uniprot_id": "RGD1_YEAST", "mass": 74619.0, "length": 666, "protein_name": "RHO GTPase-activating protein RGD1", "gene_name": "RGD1", "organism": "Yeast", "refseq_name": "GTPase-activating protein RGD1", "refseq_ac": "NP_009819", "gene_names_uniprotkb": "RGD1; YBR1728", "gene_names_refseq": "RGD1", "protein_names_uniprotkb": "RHO GTPase-activating protein RGD1; Related GAP domain protein 1; RhoGAP", "protein_names_refseq": "GTPase-activating protein RGD1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR260C); (R-SCE-6798695); (R-SCE-8980692); (R-SCE-9013148); (R-SCE-9013149); (R-SCE-9013423); (R-SCE-9013424); (R-SCE-9035034)", "pathway_count": 8, "publication_count": 17, "publication_id_list": "10526184;10590461;11779787;14562095;14562106;15922872;16087742;19684113;19779198;23454383;24374639;32597660;33491328;33508381;7813418;8465606;9769859", "class_list": "", "function": "GTPase activating protein of RHO3 and RHO4. Acts in concert with MID2 in cell integrity, which is functionally linked to the PKC pathway. Involved in various stress responses. Required at low pH for activation of the PKC pathway. Important during mating response., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VQQ7", "ec_number_list": "", "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005096 GTPase activator activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030479 actin cortical patch;GO:0030427 site of polarized growth", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0030036 actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0010508 positive regulation of autophagy;GO:0010447 response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38339-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38340-1", "uniprot_id": "NTM1_YEAST", "mass": 26068.0, "length": 232, "protein_name": "Alpha N-terminal protein methyltransferase 1", "gene_name": "TAE1", "organism": "Yeast", "refseq_name": "N-terminal protein methyltransferase", "refseq_ac": "NP_009820", "gene_names_uniprotkb": "TAE1; NTM1; YBR1729", "gene_names_refseq": "NTM1; TAE1", "protein_names_uniprotkb": "Alpha N-terminal protein methyltransferase 1; 2.1.1.244; NTM1; Translation associated element 1; X-Pro-Lys N-terminal protein methyltransferase 1", "protein_names_refseq": "N-terminal protein methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR261C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;19055778;19795423;19823750;20481588;24374639;7813418;8465606", "class_list": "", "function": "Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of the ribosomal proteins RPL12A, RPL12B, RPS25A and RPS25B., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQQ8", "ec_number_list": "2.1.1.244", "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0018016 N-terminal peptidyl-proline dimethylation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38340-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38341-1", "uniprot_id": "MIC12_YEAST", "mass": 12388.0, "length": 106, "protein_name": "MICOS complex subunit MIC12", "gene_name": "MIC12", "organism": "Yeast", "refseq_name": "Mic12p", "refseq_ac": "NP_009821", "gene_names_uniprotkb": "MIC12; AIM5; FMP51; MCS12; YBR1731", "gene_names_refseq": "AIM5; FMP51; MCS12; MIC12", "protein_names_uniprotkb": "MICOS complex subunit MIC12; Altered inheritance of mitochondria protein 5, mitochondrial; Found in mitochondrial proteome protein 51; Mitochondrial contact site complex 12 kDa subunit", "protein_names_refseq": "Mic12p", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR262C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;17322287;19300474;21944719;21987634;22009199;22814378;24374639;24687277;7813418;8465606", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQQ9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38341-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38342-1", "uniprot_id": "KDSR_YEAST", "mass": 35973.0, "length": 320, "protein_name": "3-ketodihydrosphingosine reductase TSC10", "gene_name": "TSC10", "organism": "Yeast", "refseq_name": "3-dehydrosphinganine reductase", "refseq_ac": "NP_009824", "gene_names_uniprotkb": "TSC10; YBR1734", "gene_names_refseq": "TSC10", "protein_names_uniprotkb": "3-ketodihydrosphingosine reductase TSC10; 1.1.1.102; 3-dehydrosphinganine reductase; KDS reductase; Temperature-sensitive CSG2 suppressor protein 10", "protein_names_refseq": "3-dehydrosphinganine reductase", "tax_id": 559292, "disease": "follicular lymphoma (Disease Ontology:DOID:0050873); erythrokeratodermia variabilis et progressiva 4 (Disease Ontology:DOID:0080250)", "pathway": " (sce:YBR265W); (R-SCE-1660661)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14562095;14562106;16431155;19141869;24374639;35667415;7813418;8465606;9804843", "class_list": "", "function": "Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQR2", "ec_number_list": "1.1.1.102", "go_molecular_function": "GO:0047560 3-dehydrosphinganine reductase activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006666 3-keto-sphinganine metabolic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38342-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38344-1", "uniprot_id": "REI1_YEAST", "mass": 45862.0, "length": 393, "protein_name": "Cytoplasmic 60S subunit biogenesis factor REI1", "gene_name": "REI1", "organism": "Yeast", "refseq_name": "Rei1p", "refseq_ac": "NP_009825", "gene_names_uniprotkb": "REI1; YBR1736", "gene_names_refseq": "REI1", "protein_names_uniprotkb": "Cytoplasmic 60S subunit biogenesis factor REI1; Required for isotropic bud growth protein 1; pre-60S factor REI1", "protein_names_refseq": "Rei1p", "tax_id": 559292, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (sce:YBR267W)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562095;14562106;15107529;16648468;16651379;17652132;18407956;19433447;19779198;19901025;21126336;21177495;23142985;23749301;24374639;32597660;33481703;33491328;34965436;7813418;8465606;9171100", "class_list": "", "function": "Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors like ARX1, TIF6 and ALB1 before newly synthesized large ribosomal subunits enter translation. Cooperates with the co-chaperone JJJ1 in the release of the nuclear-export factor ARX1. May act redundantly with REH1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on ARX1 recycling., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQR3", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006913 nucleocytoplasmic transport;GO:0042273 ribosomal large subunit biogenesis;GO:0007117 budding cell bud growth", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38344-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38351-1", "uniprot_id": "PAF1_YEAST", "mass": 51801.0, "length": 445, "protein_name": "RNA polymerase II-associated protein 1", "gene_name": "PAF1", "organism": "Yeast", "refseq_name": "Paf1p", "refseq_ac": "NP_009838", "gene_names_uniprotkb": "PAF1; YBR2016", "gene_names_refseq": "PAF1", "protein_names_uniprotkb": "RNA polymerase II-associated protein 1; Protein PAF1", "protein_names_refseq": "Paf1p", "tax_id": 559292, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (sce:YBR279W)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10219085;11884586;12242279;14562106;15643076;15665377;16246725;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;33502312;7813418;8091861;8552095;8812838", "class_list": "", "function": "The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of the RAD6/UBC2-BRE1 ubiquitin ligase complex, which ubiquitinates histone H2B to form H2BK123ub1. Also required for the methylation of histone H3 by the COMPASS complex to form H3K4me, by SET2 to form H3K36me, and by DOT1 to form H3K79me. RNA polymerase II associated protein important for transcription of a subset of genes. Required for both positive and negative regulation. Negatively regulates MAK16 expression. Also required for efficient CLN2 transcription in late G1 and may be involved in transcription of galactose-inducible genes., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQS4;Q9URC9", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0006360 transcription by RNA polymerase I;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P38351-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38352-1", "uniprot_id": "SAF1_YEAST", "mass": 70495.0, "length": 637, "protein_name": "SCF-associated factor 1", "gene_name": "SAF1", "organism": "Yeast", "refseq_name": "SCF ubiquitin ligase complex subunit SAF1", "refseq_ac": "NP_009839", "gene_names_uniprotkb": "SAF1; YBR2017", "gene_names_refseq": "SAF1", "protein_names_uniprotkb": "SCF-associated factor 1", "protein_names_refseq": "SCF ubiquitin ligase complex subunit SAF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR280C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11283612;12748633;16677311;17330950;17517885;17563356;18407956;19779198;19882662;21177495;23749301;24374639;33229814;33491328;7813418;8091861", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Targets AAH1 adenine deaminase for proteasome-dependent degradation upon entry into quiescence. Targets also URA7., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VQS5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P38352-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38356-1", "uniprot_id": "BSD2_YEAST", "mass": 35764.0, "length": 321, "protein_name": "Metal homeostatis protein BSD2", "gene_name": "BSD2", "organism": "Yeast", "refseq_name": "Bsd2p", "refseq_ac": "NP_009849", "gene_names_uniprotkb": "BSD2; YBR2037", "gene_names_refseq": "BSD2", "protein_names_uniprotkb": "Metal homeostatis protein BSD2; Bypass SOD defects protein 2", "protein_names_refseq": "Bsd2p", "tax_id": 559292, "disease": "stroke (Disease Ontology:DOID:0051061)", "pathway": " (sce:YBR290W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12872131;14562095;14562106;16847258;18407956;22106047;24374639;33481703;33491328;7813418;7935419;8091861;9115231;9988727", "class_list": "", "function": "Required for homeostasis of heavy metal ions such as cadmium, cobalt and copper. Controls metal ion transport and prevents metal hyperaccumulation by negatively regulating the SMF1 and SMF2 metal transport systems. Under manganese-replete conditions facilitates trafficking of SMF1 and SMF2 metal transporters to the vacuole where they are degraded., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQT5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0031398 positive regulation of protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030001 metal ion transport;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38356-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38360-1", "uniprot_id": "ATU1_YEAST", "mass": 131875.0, "length": 1216, "protein_name": "P-type cation-transporting ATPase", "gene_name": "PCA1", "organism": "Yeast", "refseq_name": "cation-transporting P-type ATPase PCA1", "refseq_ac": "NP_009854", "gene_names_uniprotkb": "PCA1; CAD2; PAY2; YBR2112", "gene_names_refseq": "CAD2; PAY2; PCA1", "protein_names_uniprotkb": "P-type cation-transporting ATPase; 7.2.2.21; Cadmium resistance protein 2; Cadmium-translocating P-type ATPase; Cd(2+)-exporting ATPase", "protein_names_refseq": "cation-transporting P-type ATPase PCA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YBR295W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10743563;14534306;17107946;18753133;21483812;2249249;24374639;7754711;7813418", "class_list": "", "function": "Cadmium transporting P-type ATPase which plays a critical role in cadmium resistance by extruding intracellular cadmium. Capable of high affinity copper ion binding, but not active copper ion transport. May play a role in copper resistance by chelating and sequestering copper ions., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQT9", "ec_number_list": "7.2.2.21;7.6.2.3;7.2.2.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005507 copper ion binding;GO:0070628 proteasome binding;GO:0008551 P-type cadmium transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005839 proteasome core complex", "go_biological_process": "GO:0055085 transmembrane transport;GO:0046686 response to cadmium ion;GO:0010273 detoxification of copper ion;GO:0030003 intracellular monoatomic cation homeostasis;GO:0015691 cadmium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38360-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38361-1", "uniprot_id": "PHO89_YEAST", "mass": 62654.0, "length": 574, "protein_name": "Phosphate permease PHO89", "gene_name": "PHO89", "organism": "Yeast", "refseq_name": "Pho89p", "refseq_ac": "NP_009855", "gene_names_uniprotkb": "PHO89; ITN1; YBR2113", "gene_names_refseq": "ITN1; PHO89", "protein_names_uniprotkb": "Phosphate permease PHO89; Na(+)/Pi cotransporter PHO89", "protein_names_refseq": "Pho89p", "tax_id": 559292, "disease": "basal ganglia calcification (Disease Ontology:DOID:0060230)", "pathway": " (sce:YBR296C); (R-SCE-427652)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12581367;12923174;17330950;19779198;23216645;23770362;24374639;32597660;33481703;7813418;9671031", "class_list": "", "function": "Sodium-phosphate symporter (PubMed:12581367, PubMed:23216645, PubMed:23770362, PubMed:9671031). Active in early growth phase., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VQU0", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006817 phosphate ion transport;GO:0035435 phosphate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38361-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38428-1", "uniprot_id": "CUE1_YEAST", "mass": 22763.0, "length": 203, "protein_name": "Coupling of ubiquitin conjugation to ER degradation protein 1", "gene_name": "CUE1", "organism": "Yeast", "refseq_name": "Cue1p", "refseq_ac": "NP_013991", "gene_names_uniprotkb": "CUE1; KIS4; YM8156.06", "gene_names_refseq": "CUE1; KIS4", "protein_names_uniprotkb": "Coupling of ubiquitin conjugation to ER degradation protein 1; Kinetochore-defect suppressor 4", "protein_names_refseq": "Cue1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR264W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10878801;10982838;10991948;11023840;11390656;11406589;12399372;12628920;14562095;14562106;16556771;16607018;16873066;17322287;23749301;24374639;33491328;9169872;9335582;9388185", "class_list": "", "function": "Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Also has a role in cold adaptation, perhaps through effects on sterol biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W090;Q03507", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex;GO:0000837 Doa10p ubiquitin ligase complex", "go_biological_process": "GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38428-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38429-1", "uniprot_id": "SAP30_YEAST", "mass": 23026.0, "length": 201, "protein_name": "Transcriptional regulatory protein SAP30", "gene_name": "SAP30", "organism": "Yeast", "refseq_name": "Sap30p", "refseq_ac": "NP_013990", "gene_names_uniprotkb": "SAP30; YM8156.05", "gene_names_refseq": "SAP30", "protein_names_uniprotkb": "Transcriptional regulatory protein SAP30", "protein_names_refseq": "Sap30p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR263W); (R-SCE-3214815)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10388812;12672825;14562095;14562106;16286008;16314178;17322287;24374639;33491328;9169872;9651585", "class_list": "", "function": "Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W089;Q03501", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000118 histone deacetylase complex;GO:0070210 Rpd3L-Expanded complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38429-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38439-1", "uniprot_id": "LEO1_YEAST", "mass": 53920.0, "length": 464, "protein_name": "RNA polymerase-associated protein LEO1", "gene_name": "LEO1", "organism": "Yeast", "refseq_name": "Paf1-complex subunit LEO1", "refseq_ac": "NP_014766", "gene_names_uniprotkb": "LEO1; O3278; YOR3278C", "gene_names_refseq": "LEO1", "protein_names_uniprotkb": "RNA polymerase-associated protein LEO1", "protein_names_refseq": "Paf1-complex subunit LEO1", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR123C)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "11884586;1429680;14562106;15643076;16246725;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20190278;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33481703;33491328;33502312;8018723;8904341;9169874;9200815", "class_list": "", "function": "The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2I1", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003712 transcription coregulator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0006325 chromatin organization;GO:0006368 transcription elongation by RNA polymerase II;GO:0006353 DNA-templated transcription termination;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0090262 regulation of transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P38439-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38555-1", "uniprot_id": "YPT31_YEAST", "mass": 24469.0, "length": 223, "protein_name": "GTP-binding protein YPT31/YPT8", "gene_name": "YPT31", "organism": "Yeast", "refseq_name": "Rab family GTPase YPT31", "refseq_ac": "NP_010948", "gene_names_uniprotkb": "YPT31; YPT8", "gene_names_refseq": "YPT31; YPT8", "protein_names_uniprotkb": "GTP-binding protein YPT31/YPT8; Rab GTPase YPT31", "protein_names_refseq": "Rab family GTPase YPT31", "tax_id": 559292, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (sce:YER031C); (R-SCE-8873719)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10559187;11102533;11785952;11943201;12478387;14562106;18407956;19779198;19795423;19823750;21126336;23078654;23749301;24374639;24909858;33481703;33491328;8017109;8978673;9151665;9169868;9724632", "class_list": "", "function": "Required for protein transport in the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Plays a role in autophagy., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLT0", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0006914 autophagy;GO:0016192 vesicle-mediated transport;GO:0006887 exocytosis;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38555-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38590-1", "uniprot_id": "MSG5_YEAST", "mass": 54217.0, "length": 489, "protein_name": "Tyrosine-protein phosphatase MSG5", "gene_name": "MSG5", "organism": "Yeast", "refseq_name": "tyrosine/serine/threonine protein phosphatase MSG5", "refseq_ac": "NP_014345", "gene_names_uniprotkb": "MSG5; N2480; YNL2480W", "gene_names_refseq": "MSG5", "protein_names_uniprotkb": "Tyrosine-protein phosphatase MSG5; 3.1.3.48", "protein_names_refseq": "tyrosine/serine/threonine protein phosphatase MSG5", "tax_id": 559292, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); carcinoma (Disease Ontology:DOID:305)", "pathway": " (sce:YNL053W); (R-SCE-202670)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "14562106;17330950;18407956;19779198;20489023;23749301;24374639;2836092;32597660;33481703;33491328;8306972;8533472;9169873", "class_list": "", "function": "Dual specificity phosphatase that dephosphorylates MAP kinase FUS3 on both a Tyr and a Ser or Thr. Has a role in adaptation to pheromone., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 41, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W1C6", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.2;2.7.11.24", "go_molecular_function": "GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071507 pheromone response MAPK cascade;GO:0060237 regulation of fungal-type cell wall organization;GO:0071852 fungal-type cell wall organization or biogenesis;GO:1903138 negative regulation of cell integrity MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38590-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38604-1", "uniprot_id": "ERG7_YEAST", "mass": 83460.0, "length": 731, "protein_name": "Lanosterol synthase ERG7", "gene_name": "ERG7", "organism": "Yeast", "refseq_name": "lanosterol synthase ERG7", "refseq_ac": "NP_011939", "gene_names_uniprotkb": "ERG7", "gene_names_refseq": "ERG7", "protein_names_uniprotkb": "Lanosterol synthase ERG7; 2,3-epoxysqualene--lanosterol cyclase ERG7; 5.4.99.7; Ergosterol biosynthetic protein 7; OSC; Oxidosqualene--lanosterol cyclase ERG7", "protein_names_refseq": "lanosterol synthase ERG7", "tax_id": 559292, "disease": "hypotrichosis 14 (Disease Ontology:DOID:0080582); alopecia-mental retardation syndrome 4 (Disease Ontology:DOID:0080950); cataract 44 (Disease Ontology:DOID:0110267); cataract (Disease Ontology:DOID:83)", "pathway": " (sce:YHR072W); (R-SCE-9969896)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11706015;12842197;14562095;14562106;16235265;1731628;17322287;22814378;24374639;32597660;32679672;33481703;33491328;8041797;8091229;8134375", "class_list": "", "function": "Lanosterol synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:12842197, PubMed:16235265, PubMed:1731628). ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core (PubMed:12842197, PubMed:1731628). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL21;Q92327", "ec_number_list": "5.4.99.7", "go_molecular_function": "GO:0000250 lanosterol synthase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process;GO:0016104 triterpenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38604-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38620-1", "uniprot_id": "KPR2_YEAST", "mass": 34765.0, "length": 318, "protein_name": "Ribose-phosphate pyrophosphokinase 2", "gene_name": "PRS2", "organism": "Yeast", "refseq_name": "ribose phosphate diphosphokinase subunit PRS2", "refseq_ac": "NP_011025", "gene_names_uniprotkb": "PRS2; PRPS2; PRS", "gene_names_refseq": "PRS2", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 2; 2.7.6.1; Phosphoribosyl pyrophosphate synthase 2", "protein_names_refseq": "ribose phosphate diphosphokinase subunit PRS2", "tax_id": 559292, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210); phosphoribosylpyrophosphate synthetase superactivity (Disease Ontology:DOID:0111260); X-linked deafness 1 (Disease Ontology:DOID:0111739); retinitis pigmentosa (Disease Ontology:DOID:10584); gout (Disease Ontology:DOID:13189)", "pathway": " (sce:YER099C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10212224;14562095;14562106;15280369;17322287;19779198;24374639;33481703;7992503;9169868", "class_list": "", "function": "5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM06", "ec_number_list": "2.7.6.1", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004749 ribose phosphate diphosphokinase activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0009156 ribonucleoside monophosphate biosynthetic process;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38620-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38624-1", "uniprot_id": "PSB1_YEAST", "mass": 23548.0, "length": 215, "protein_name": "Proteasome subunit beta type-1", "gene_name": "PRE3", "organism": "Yeast", "refseq_name": "proteasome core particle subunit beta 1", "refseq_ac": "NP_012533", "gene_names_uniprotkb": "PRE3; J1407", "gene_names_refseq": "CRL21; PRE3", "protein_names_uniprotkb": "Proteasome subunit beta type-1; 3.4.25.1; Macropain subunit PRE3; Multicatalytic endopeptidase complex subunit PRE3; Proteasome component PRE3; Proteinase YSCE subunit PRE3", "protein_names_refseq": "proteasome core particle subunit beta 1", "tax_id": 559292, "disease": "lymphoma (Disease Ontology:DOID:0060058); colorectal carcinoma (Disease Ontology:DOID:0080199); adult respiratory distress syndrome (Disease Ontology:DOID:11394); vitiligo (Disease Ontology:DOID:12306); Huntington's disease (Disease Ontology:DOID:12858); peptic esophagitis (Disease Ontology:DOID:13976); multiple sclerosis (Disease Ontology:DOID:2377); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); ankylosing spondylitis (Disease Ontology:DOID:7147); autoimmune thyroiditis (Disease Ontology:DOID:7188); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (sce:YJL001W); (R-SCE-1236974); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-9907900); (R-SCE-9912633)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "11062564;11081519;14562106;16531229;16608349;16793518;18407956;20227375;22814378;22927375;24374639;33491328;7781614;7907993;8641269;9087403", "class_list": "", "function": "The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. PRE3 and PRE4 are necessary for the peptidyl-glutamyl-peptide-hydrolyzing activity., [UniProtKB]; This subunit is necessary for the peptidylglutamyl-peptide hydrolyzing activity., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VWH4", "ec_number_list": "3.4.25.1;3.4.19.12;2.7.11.1", "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010499 proteasomal ubiquitin-independent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38624-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38626-1", "uniprot_id": "NCB5R_YEAST", "mass": 31494.0, "length": 284, "protein_name": "NADH-cytochrome b5 reductase 1", "gene_name": "CBR1", "organism": "Yeast", "refseq_name": "cytochrome-b5 reductase", "refseq_ac": "NP_012221", "gene_names_uniprotkb": "CBR1; CBR5; CBR", "gene_names_refseq": "CBR1; CBR5", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 1; 1.6.2.2; Microsomal cytochrome b reductase; P35", "protein_names_refseq": "cytochrome-b5 reductase", "tax_id": 559292, "disease": "estrogen-receptor negative breast cancer (Disease Ontology:DOID:0060076); methemoglobinemia (Disease Ontology:DOID:10783); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (sce:YIL043C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10622712;12748633;14562095;14562106;14930;15905473;16407407;17895367;24374639;27694803;31463593;33481703;34154323;6442167;8307010;9169870", "class_list": "", "function": "NADH-dependent reductase for KTI11/DPH3 and cytochrome b5 (PubMed:10622712, PubMed:14930, PubMed:27694803, PubMed:31463593, PubMed:34154323). Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:27694803, PubMed:31463593, PubMed:34154323). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:31463593, PubMed:34154323). By reducing KTI11/DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex (PubMed:27694803). The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (PubMed:10622712). Plays a role in bud morphology (PubMed:17895367)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVN9", "ec_number_list": "1.6.2.2", "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0017183 protein histidyl modification to diphthamide;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38626-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38627-1", "uniprot_id": "URA8_YEAST", "mass": 64511.0, "length": 578, "protein_name": "CTP synthase 2", "gene_name": "URA8", "organism": "Yeast", "refseq_name": "CTP synthase URA8", "refseq_ac": "NP_012637", "gene_names_uniprotkb": "URA8; J1962", "gene_names_refseq": "URA8", "protein_names_uniprotkb": "CTP synthase 2; 6.3.4.2; CTP synthetase 2; UTP--ammonia ligase 2", "protein_names_refseq": "CTP synthase URA8", "tax_id": 559292, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); immunodeficiency 24 (Disease Ontology:DOID:0111938); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (sce:YJR103W); (R-SCE-499943)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14562095;14562106;24374639;33491328;7559626;8121398;8641269;9668079", "class_list": "", "function": "Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWS2", "ec_number_list": "6.3.4.2", "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0003883 CTP synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097268 cytoophidium;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0044210 'de novo' CTP biosynthetic process;GO:0006241 CTP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38627-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38628-1", "uniprot_id": "AGM1_YEAST", "mass": 62067.0, "length": 557, "protein_name": "Phosphoacetylglucosamine mutase", "gene_name": "PCM1", "organism": "Yeast", "refseq_name": "phosphoacetylglucosamine mutase PCM1", "refseq_ac": "NP_010856", "gene_names_uniprotkb": "PCM1; AGM1", "gene_names_refseq": "AGM1; PCM1", "protein_names_uniprotkb": "Phosphoacetylglucosamine mutase; 5.4.2.3; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; PAGM; PGM-complementing protein 1", "protein_names_refseq": "phosphoacetylglucosamine mutase PCM1", "tax_id": 559292, "disease": "immunodeficiency 23 (Disease Ontology:DOID:0111953); cancer (Disease Ontology:DOID:162); teratoma (Disease Ontology:DOID:3307); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (sce:YEL058W); (R-SCE-446210)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "14562095;14562106;17330950;18407956;19684113;19779198;19795423;19823750;21177495;23749301;24374639;24909858;32597660;33481703;33491328;8119301;8174553;9169868", "class_list": "", "function": "Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins (PubMed:8174553). Also has phosphoglucomutase activity (PubMed:8119301)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLJ2", "ec_number_list": "5.4.2.3", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004610 phosphoacetylglucosamine mutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0006031 chitin biosynthetic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P38628-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38630-1", "uniprot_id": "RFC1_YEAST", "mass": 94903.0, "length": 861, "protein_name": "Replication factor C subunit 1", "gene_name": "RFC1", "organism": "Yeast", "refseq_name": "replication factor C subunit 1", "refseq_ac": "NP_014860", "gene_names_uniprotkb": "RFC1; CDC44; YOR50-7", "gene_names_refseq": "CDC44; RFC1", "protein_names_uniprotkb": "Replication factor C subunit 1; Activator 1 95 kDa subunit; Cell division control protein 44; Replication factor C1", "protein_names_refseq": "replication factor C subunit 1", "tax_id": 559292, "disease": "cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (Disease Ontology:DOID:0070148); congenital heart disease (Disease Ontology:DOID:1682); West Nile fever (Disease Ontology:DOID:2366)", "pathway": " (sce:YOR217W); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-69091)", "pathway_count": 4, "publication_count": 26, "publication_id_list": "12665596;14530260;14562106;15201901;15964801;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22814378;23749301;24374639;30516470;32597660;33481703;33491328;7651383;8264593;8840505;9169874", "class_list": "", "function": "Component of the ATP-dependent clamp loader RFC complex for the POL30/PCNA homotrimer DNA clamp. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Replication factor C (RFC or activator 1) complex acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2S3", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0006272 leading strand elongation;GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0051301 cell division;GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P38630-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38632-1", "uniprot_id": "NSE2_YEAST", "mass": 30354.0, "length": 267, "protein_name": "E3 SUMO-protein ligase MMS21", "gene_name": "MMS21", "organism": "Yeast", "refseq_name": "SUMO ligase MMS21", "refseq_ac": "NP_010896", "gene_names_uniprotkb": "MMS21; NSE2", "gene_names_refseq": "MMS21; NSE2; PSO10", "protein_names_uniprotkb": "E3 SUMO-protein ligase MMS21; 2.3.2.-; E3 SUMO-protein transferase MMS21; Methyl methanesulfonate-sensitivity protein 21; Non-SMC element 2; Non-structural maintenance of chromosome element 2", "protein_names_refseq": "SUMO ligase MMS21", "tax_id": 559292, "disease": "Seckel syndrome 10 (Disease Ontology:DOID:0070008); Bloom syndrome (Disease Ontology:DOID:2717)", "pathway": " (sce:YEL019C); (R-SCE-3108214)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14562095;14562106;14690591;15738391;17322287;21126336;24374639;25659338;30516470;33491328;9169868", "class_list": "", "function": "Acts as an E3 ligase mediating SUMO/Smt3 attachment to SMC5 and YKU70. Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLN0", "ec_number_list": "2.3.2.-;2.3.2.27", "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0019789 SUMO transferase activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0016925 protein sumoylation;GO:0000724 double-strand break repair via homologous recombination;GO:1990683 DNA double-strand break attachment to nuclear envelope", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38632-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38637-1", "uniprot_id": "STS1_YEAST", "mass": 36485.0, "length": 319, "protein_name": "Tethering factor for nuclear proteasome STS1", "gene_name": "STS1", "organism": "Yeast", "refseq_name": "Sts1p", "refseq_ac": "NP_012276", "gene_names_uniprotkb": "STS1; DBF8; SSM5; YIB11C", "gene_names_refseq": "DBF8; SSM5; STS1", "protein_names_uniprotkb": "Tethering factor for nuclear proteasome STS1; Dumbbell former protein 8; SEC23 suppressor 1", "protein_names_refseq": "Sts1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR011C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10913188;14562106;17322287;17916559;21075847;24374639;7762303;7925484;8065366;8914516;9169870", "class_list": "", "function": "Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins. Required for efficient chromosome segregation. Restores protein transport and ribosomal RNA stability., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVU1;P35188", "ec_number_list": "", "go_molecular_function": "GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007059 chromosome segregation;GO:0015031 protein transport;GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system;GO:0031144 proteasome localization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38637-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38692-1", "uniprot_id": "KIC1_YEAST", "mass": 117062.0, "length": 1080, "protein_name": "Serine/threonine-protein kinase KIC1", "gene_name": "KIC1", "organism": "Yeast", "refseq_name": "putative serine/threonine protein kinase KIC1", "refseq_ac": "NP_011970", "gene_names_uniprotkb": "KIC1; NRK1", "gene_names_refseq": "KIC1; NRK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase KIC1; 2.7.11.1; Kinase that interacts with CDC31; N-rich kinase 1", "protein_names_refseq": "putative serine/threonine protein kinase KIC1", "tax_id": 559292, "disease": "ciliopathy (Disease Ontology:DOID:0060340); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (sce:YHR102W); (R-SCE-75153)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "14562106;17563356;18407956;19779198;19795423;19823750;20489023;20702584;21126336;23749301;24374639;31208443;32597660;33229814;33481703;33491328;8091229;9813095", "class_list": "", "function": "Protein kinase involved in morphogenesis and cell integrity., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 36, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 36, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 36, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 37, "binding_glycan_count": 0, "secondary_ac_list": "D3DL52", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000131 incipient cellular bud site;GO:0005933 cellular bud;GO:0043332 mating projection tip", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007118 budding cell apical bud growth;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 5.6, "record_id": "P38692-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38695-1", "uniprot_id": "HXT5_YEAST", "mass": 66251.0, "length": 592, "protein_name": "Probable glucose transporter HXT5", "gene_name": "HXT5", "organism": "Yeast", "refseq_name": "hexose transporter HXT5", "refseq_ac": "NP_011964", "gene_names_uniprotkb": "HXT5", "gene_names_refseq": "HXT5", "protein_names_uniprotkb": "Probable glucose transporter HXT5", "protein_names_refseq": "hexose transporter HXT5", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR096C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12872131;16847258;17287358;18407956;19779198;24374639;33491328;8091229", "class_list": "", "function": "Probable glucose transporter., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DL46", "ec_number_list": "", "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0008643 carbohydrate transport;GO:0008645 hexose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38695-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38697-1", "uniprot_id": "IMDH2_YEAST", "mass": 56530.0, "length": 523, "protein_name": "Inosine-5'-monophosphate dehydrogenase 2", "gene_name": "IMD2", "organism": "Yeast", "refseq_name": "IMP dehydrogenase IMD2", "refseq_ac": "NP_012088", "gene_names_uniprotkb": "IMD2; PUR5", "gene_names_refseq": "IMD2; PUR5", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase 2; 1.1.1.205; IMP dehydrogenase 2; IMPD 2; IMPDH 2", "protein_names_refseq": "IMP dehydrogenase IMD2", "tax_id": 559292, "disease": "Leber congenital amaurosis 11 (Disease Ontology:DOID:0110216); retinitis pigmentosa 10 (Disease Ontology:DOID:0110388); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (sce:YHR216W); (R-SCE-6798695); (R-SCE-73817); (R-SCE-9748787)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12746440;14562095;14562106;15292516;16278936;24374639;33481703;8091229", "class_list": "", "function": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. In contrast to the other IMPDH alleles IMD3 and IMD4, the enzymatic activity of IMD2 seems to be intrinsically drug resistant., [UniProtKB, PubMed, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLH1", "ec_number_list": "2.7.1.40;3.5.3.1;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.4.1.1;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;5.2.1.8;1.11.1.6;3.5.4.6;2.7.1.11;2.7.1.2;1.1.1.42;2.7.11.13;3.4.25.1;3.6.4.6;3.6.5.-;2.7.11.24;3.6.4.12;5.4.2.2;1.11.1.27;1.11.1.25;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;2.7.1.35;3.4.19.12;2.4.2.7;4.6.1.19;5.4.2.7;2.3.2.26;3.-.-.-;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;5.3.4.1", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003938 IMP dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0006183 GTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38697-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38701-1", "uniprot_id": "RS20_YEAST", "mass": 13907.0, "length": 121, "protein_name": "Small ribosomal subunit protein uS10", "gene_name": "RPS20", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS10 RPS20", "refseq_ac": "NP_011848", "gene_names_uniprotkb": "RPS20; URP2", "gene_names_refseq": "RPS20; URP2", "protein_names_uniprotkb": "Small ribosomal subunit protein uS10; 40S ribosomal protein S20", "protein_names_refseq": "40S ribosomal protein uS10 RPS20", "tax_id": 559292, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (sce:YHL015W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 22, "publication_id_list": "10601260;11701127;12872131;14557538;14976550;15665377;19795423;21109664;22096102;22106047;22814378;24374639;24524803;28757607;30609991;31819057;33481703;33491328;36627279;8021936;8091229;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKP7", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38701-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38704-1", "uniprot_id": "STP2_YEAST", "mass": 60792.0, "length": 541, "protein_name": "Transcription factor STP2", "gene_name": "STP2", "organism": "Yeast", "refseq_name": "Stp2p", "refseq_ac": "NP_011870", "gene_names_uniprotkb": "STP2", "gene_names_refseq": "STP2", "protein_names_uniprotkb": "Transcription factor STP2", "protein_names_refseq": "Stp2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR006W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10648791;11212916;12502738;14562095;14562106;15197729;15314160;16735580;17085444;17322287;18407956;23749301;24374639;33481703;33491328;8091229;9171100", "class_list": "", "function": "Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases BAP2 and BAP3. Binding to promoters is facilitated by DAL81 (By similarity). Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV0;E9P956", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38704-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38710-1", "uniprot_id": "INM1_YEAST", "mass": 32823.0, "length": 295, "protein_name": "Inositol monophosphatase 1", "gene_name": "INM1", "organism": "Yeast", "refseq_name": "inositol monophosphate 1-phosphatase INM1", "refseq_ac": "NP_011912", "gene_names_uniprotkb": "INM1; IMP1", "gene_names_refseq": "INM1", "protein_names_uniprotkb": "Inositol monophosphatase 1; 3.1.3.25; IMP 1; IMPase 1; Inositol-1(or 4)-monophosphatase 1", "protein_names_refseq": "inositol monophosphate 1-phosphatase INM1", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder 59 (Disease Ontology:DOID:0081221); intellectual disability (Disease Ontology:DOID:1059); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (sce:YHR046C); (R-SCE-1855183)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10096091;12593845;14562095;14562106;24374639;33481703;33491328;8091229", "class_list": "", "function": "Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKZ4", "ec_number_list": "3.1.3.25", "go_molecular_function": "GO:0046872 metal ion binding;GO:0008934 inositol monophosphate 1-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007165 signal transduction;GO:0006021 inositol biosynthetic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0071545 inositol phosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38710-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38711-1", "uniprot_id": "RS27B_YEAST", "mass": 8865.0, "length": 82, "protein_name": "Small ribosomal subunit protein eS27B", "gene_name": "RPS27B", "organism": "Yeast", "refseq_name": "40S ribosomal protein eS27 RPS27B", "refseq_ac": "NP_011885", "gene_names_uniprotkb": "RPS27B", "gene_names_refseq": "RPS27B", "protein_names_uniprotkb": "Small ribosomal subunit protein eS27B; 40S ribosomal protein S27-B; RP61; YS20", "protein_names_refseq": "40S ribosomal protein eS27 RPS27B", "tax_id": 559292, "disease": "Diamond-Blackfan anemia 17 (Disease Ontology:DOID:0111880)", "pathway": " (sce:YHR021C); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "10601260;14562095;18407956;19779198;22096102;23749301;24374639;24524803;8091229;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKW6", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38711-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38712-1", "uniprot_id": "RRP3_YEAST", "mass": 55969.0, "length": 501, "protein_name": "ATP-dependent rRNA helicase RRP3", "gene_name": "RRP3", "organism": "Yeast", "refseq_name": "RNA-dependent ATPase RRP3", "refseq_ac": "NP_011932", "gene_names_uniprotkb": "RRP3", "gene_names_refseq": "RRP3", "protein_names_uniprotkb": "ATP-dependent rRNA helicase RRP3; 3.6.4.13; Ribosomal RNA-processing protein 3", "protein_names_refseq": "RNA-dependent ATPase RRP3", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR065C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "12748633;16449634;17330950;18407956;18975973;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23153376;23749301;24374639;30516470;32597660;33481703;33491328;8091229;8774901", "class_list": "", "function": "ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL14;Q6TQT5;Q6TQT6", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;2.1.1.-;2.7.11.1;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.1.1.260;2.7.4.3;3.1.13.-;7.2.2.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0008186 ATP-dependent activity, acting on RNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006364 rRNA processing;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P38712-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38715-1", "uniprot_id": "GRE3_YEAST", "mass": 37119.0, "length": 327, "protein_name": "NADPH-dependent aldose reductase GRE3", "gene_name": "GRE3", "organism": "Yeast", "refseq_name": "trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))", "refseq_ac": "NP_011972", "gene_names_uniprotkb": "GRE3; XYL1; XYLA", "gene_names_refseq": "GRE3", "protein_names_uniprotkb": "NADPH-dependent aldose reductase GRE3; 1.1.1.21; 1.1.1.430; 1.1.1.431; AR; Genes de respuesta a estres protein 3; NADPH-dependent aldo-keto reductase GRE3; Xylose reductase", "protein_names_refseq": "trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); ductal carcinoma in situ (Disease Ontology:DOID:0060074); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); congenital bile acid synthesis defect 2 (Disease Ontology:DOID:0111069); 46,XY sex reversal 8 (Disease Ontology:DOID:0111773); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); leukemia (Disease Ontology:DOID:1240); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YHR104W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10407268;11481678;11525399;11722921;14562095;14562106;18407956;21126336;24374639;33491328;7747971;8091229;9730277", "class_list": "", "function": "Aldose reductase with a broad substrate specificity (Probable) (PubMed:7747971). Reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde under stress conditions. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation (PubMed:11525399). In pentose-fermenting yeasts, aldose reductase catalyzes the reduction of xylose into xylitol, with a preference for NADPH as cosubstrate (PubMed:11481678, PubMed:11722921). The purified enzyme catalyzes this reaction, but the inability of S.cerevisiae to grow on xylose as sole carbon source indicates that the physiological function is more likely methylglyoxal reduction (Probable) (PubMed:11722921)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL54", "ec_number_list": "1.1.1.21;1.1.1.430;1.1.1.431", "go_molecular_function": "GO:0003729 mRNA binding;GO:0004032 aldose reductase (NADPH) activity;GO:0032866 D-xylose reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0019388 galactose catabolic process;GO:0042843 D-xylose catabolic process;GO:0071470 cellular response to osmotic stress;GO:0019568 arabinose catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P38715-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38717-1", "uniprot_id": "SIP3_YEAST", "mass": 142820.0, "length": 1229, "protein_name": "Membrane-anchored lipid-binding protein SIP3", "gene_name": "SIP3", "organism": "Yeast", "refseq_name": "Sip3p", "refseq_ac": "NP_014142", "gene_names_uniprotkb": "SIP3; LAM3; N0844", "gene_names_refseq": "LAM3; SIP3", "protein_names_uniprotkb": "Membrane-anchored lipid-binding protein SIP3; Lipid transfer protein anchored at membrane contact sites 3; SNF1-interacting protein 3", "protein_names_refseq": "Sip3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL257C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;16847258;18407956;21126336;24374639;26001273;33491328;8127709;9169873;9234673", "class_list": "", "function": "May be involved in sterol transfer between intracellular membranes., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0T6", "ec_number_list": "", "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38717-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38720-1", "uniprot_id": "6PGD1_YEAST", "mass": 53543.0, "length": 489, "protein_name": "6-phosphogluconate dehydrogenase, decarboxylating 1", "gene_name": "GND1", "organism": "Yeast", "refseq_name": "phosphogluconate dehydrogenase (decarboxylating) GND1", "refseq_ac": "NP_012053", "gene_names_uniprotkb": "GND1", "gene_names_refseq": "GND1", "protein_names_uniprotkb": "6-phosphogluconate dehydrogenase, decarboxylating 1; 1.1.1.44", "protein_names_refseq": "phosphogluconate dehydrogenase (decarboxylating) GND1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR183W); (R-SCE-71336)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14562095;14562106;17570834;18407956;19779198;23749301;24374639;32597660;33481703;33491328;7895733;8091229", "class_list": "", "function": "Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLD1", "ec_number_list": "1.1.1.44", "go_molecular_function": "GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0009051 pentose-phosphate shunt, oxidative branch;GO:0034599 cellular response to oxidative stress;GO:0019521 D-gluconate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38720-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38731-1", "uniprot_id": "ARN1_YEAST", "mass": 70899.0, "length": 627, "protein_name": "Siderophore iron transporter ARN1", "gene_name": "ARN1", "organism": "Yeast", "refseq_name": "siderophore transporter", "refseq_ac": "NP_011823", "gene_names_uniprotkb": "ARN1", "gene_names_refseq": "ARN1", "protein_names_uniprotkb": "Siderophore iron transporter ARN1; Ferrichrome permease", "protein_names_refseq": "siderophore transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL040C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10744769;10748025;12721368;16847258;24374639;33481703;33491328;8091229", "class_list": "", "function": "Involved in the transport of siderophore ferrichrome and so has a role in iron homeostasis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKS9", "ec_number_list": "", "go_molecular_function": "GO:0015343 siderophore-iron transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0015891 siderophore transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38736-1", "uniprot_id": "GOSR1_YEAST", "mass": 25395.0, "length": 223, "protein_name": "Golgi SNAP receptor complex member 1", "gene_name": "GOS1", "organism": "Yeast", "refseq_name": "Gos1p", "refseq_ac": "NP_011832", "gene_names_uniprotkb": "GOS1", "gene_names_refseq": "GOS1", "protein_names_uniprotkb": "Golgi SNAP receptor complex member 1; Golgi SNARE protein 1; Protein transport protein GOS1", "protein_names_refseq": "Gos1p", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (sce:YHL031C); (R-SCE-6807878); (R-SCE-6811438)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10591633;11160819;11689439;11959998;12429822;16107716;16699523;17330950;19779198;20702584;21177495;22814378;23749301;24374639;33481703;33491328;8091229;9211930;9755865", "class_list": "", "function": "Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Rescues alpha-factor maturation defects., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKT7", "ec_number_list": "", "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048193 Golgi vesicle transport;GO:0006906 vesicle fusion;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P38736-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38741-1", "uniprot_id": "RIM4_YEAST", "mass": 80109.0, "length": 713, "protein_name": "Meiotic activator RIM4", "gene_name": "RIM4", "organism": "Yeast", "refseq_name": "Rim4p", "refseq_ac": "NP_011839", "gene_names_uniprotkb": "RIM4", "gene_names_refseq": "RIM4", "protein_names_uniprotkb": "Meiotic activator RIM4; Regulator of IME2 protein 4", "protein_names_refseq": "Rim4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHL024W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10806425;11713679;15955809;17322287;17551511;18407956;19779198;20702584;21177495;24374639;29738715;33229814;33481703;33491328;35508136;8091229;8417990", "class_list": "", "function": "Positive regulator of sporulation-specific genes and of sporulation. Required for premeiotic DNA synthesis and meiotic chromosomal segregation. May act in a nutritional signaling pathway., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 45, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D3DKU4;E9P8V3", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0017069 snRNA binding;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0017148 negative regulation of translation;GO:0000398 mRNA splicing, via spliceosome;GO:0007131 reciprocal meiotic recombination;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P38741-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38742-1", "uniprot_id": "NPR3_YEAST", "mass": 129973.0, "length": 1146, "protein_name": "Nitrogen permease regulator 3", "gene_name": "NPR3", "organism": "Yeast", "refseq_name": "Npr3p", "refseq_ac": "NP_011840", "gene_names_uniprotkb": "NPR3; RMD11", "gene_names_refseq": "NPR3; RMD11", "protein_names_uniprotkb": "Nitrogen permease regulator 3; Required for meiotic nuclear division protein 11", "protein_names_refseq": "Npr3p", "tax_id": 559292, "disease": "familial focal epilepsy with variable foci 3 (Disease Ontology:DOID:0081423); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YHL023C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12586695;15665377;17287358;17330950;17563356;18407956;19521502;19779198;19795423;19823750;20489023;21126336;21177495;21454883;23749301;24374639;32597660;33481703;33491328;8091229", "class_list": "", "function": "Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 41, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DKU5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005774 vacuolar membrane;GO:1990130 GATOR1 complex;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:0015031 protein transport;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0010508 positive regulation of autophagy;GO:0034198 cellular response to amino acid starvation;GO:0006995 cellular response to nitrogen starvation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P38742-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38755-1", "uniprot_id": "OSH7_YEAST", "mass": 49805.0, "length": 437, "protein_name": "Oxysterol-binding protein homolog 7", "gene_name": "OSH7", "organism": "Yeast", "refseq_name": "oxysterol-binding protein related protein OSH7", "refseq_ac": "NP_011863", "gene_names_uniprotkb": "OSH7", "gene_names_refseq": "OSH7", "protein_names_uniprotkb": "Oxysterol-binding protein homolog 7; ORP 7; OSBP-related protein 7; Oxysterol-binding protein-related protein 7", "protein_names_refseq": "oxysterol-binding protein related protein OSH7", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR001W); (R-SCE-1482801); (R-SCE-192105)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11238399;14562106;15173322;16096648;17322287;20008566;22106047;23934110;24374639;26206936;8091229", "class_list": "", "function": "ipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:15173322). Involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the PM in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation. Thus, by maintaining a PI4P gradient at the ER/PM interface, SAC1 drives PS transport (PubMed:23934110, PubMed:26206936). Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKR7", "ec_number_list": "", "go_molecular_function": "GO:0005548 phospholipid transporter activity;GO:0008289 lipid binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0032934 sterol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015914 phospholipid transport;GO:0016125 sterol metabolic process;GO:0006887 exocytosis;GO:0030011 maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38755-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38758-1", "uniprot_id": "TDA3_YEAST", "mass": 57614.0, "length": 523, "protein_name": "Putative oxidoreductase TDA3", "gene_name": "TDA3", "organism": "Yeast", "refseq_name": "Tda3p", "refseq_ac": "NP_011873", "gene_names_uniprotkb": "TDA3; BTN3", "gene_names_refseq": "BTN3; TDA3", "protein_names_uniprotkb": "Putative oxidoreductase TDA3; 1.-.-.-; Batten disease protein 3; Topoisomerase I damage affected protein 3", "protein_names_refseq": "Tda3p", "tax_id": 559292, "disease": "nuclear type mitochondrial complex I deficiency 19 (Disease Ontology:DOID:0112085)", "pathway": " (sce:YHR009C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10684247;12748633;14562095;14562106;17287358;17563356;18407956;19779198;19795423;19823750;20219942;20702584;21126336;21173034;21177495;21441304;23749301;24374639;30516470;32597660;33481703;33491328;8091229", "class_list": "", "function": "Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi. Regulates YIF1 and KEX2 localization. Required for fast DNA replication., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKV4", "ec_number_list": "", "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005770 late endosome", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P38758-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38766-1", "uniprot_id": "RRM3_YEAST", "mass": 81581.0, "length": 723, "protein_name": "ATP-dependent DNA helicase RRM3", "gene_name": "RRM3", "organism": "Yeast", "refseq_name": "DNA helicase", "refseq_ac": "NP_011896", "gene_names_uniprotkb": "RRM3; RTT104", "gene_names_refseq": "RRM3; RTT104", "protein_names_uniprotkb": "ATP-dependent DNA helicase RRM3; 5.6.2.3; DNA 5'-3' helicase RRM3; Regulation of Ty1 transposition protein 104; rDNA recombination mutation protein 3", "protein_names_refseq": "DNA helicase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR031C)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "10693764;11779788;12050116;12239216;12686542;14562106;14690605;15037547;15060144;15060145;15082794;15542831;15579680;15775982;15829566;15863512;15907372;16103218;16137624;16327883;16631586;17114583;18407956;19168400;19414561;21087929;21172804;23657261;23749301;24374639;33481703;33491328;8091229;8293975", "class_list": "", "function": "5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Needed for normal fork progression through over 1000 discrete sites scattered throughout the genome, like rDNA, tRNA genes, centromeres, active replication origins, or transcriptional silencers. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in regulation of Ty1 transposition and protects the genome from instability at nascent sites of retrotransposition. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Also plays a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DKX8", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity;GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005739 mitochondrion;GO:0005657 replication fork;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0000723 telomere maintenance;GO:0006260 DNA replication;GO:0071932 replication fork reversal;GO:0097046 replication fork progression beyond termination site", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P38766-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38770-1", "uniprot_id": "BRL1_YEAST", "mass": 53385.0, "length": 471, "protein_name": "Nucleus export protein BRL1", "gene_name": "BRL1", "organism": "Yeast", "refseq_name": "Brl1p", "refseq_ac": "NP_011901", "gene_names_uniprotkb": "BRL1", "gene_names_refseq": "BRL1", "protein_names_uniprotkb": "Nucleus export protein BRL1; BRR6-like protein 1", "protein_names_refseq": "Brl1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR036W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;15882446;16847258;19779198;22814378;23749301;24374639;32597660;33481703;33491328;8091229", "class_list": "", "function": "Involved in mRNA and protein export from nucleus., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DKY3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0015031 protein transport;GO:0055088 lipid homeostasis;GO:0006998 nuclear envelope organization;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38770-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38778-1", "uniprot_id": "SMF2_YEAST", "mass": 59768.0, "length": 549, "protein_name": "Manganese transporter SMF2", "gene_name": "SMF2", "organism": "Yeast", "refseq_name": "divalent metal ion transporter SMF2", "refseq_ac": "NP_011917", "gene_names_uniprotkb": "SMF2", "gene_names_refseq": "SMF2", "protein_names_uniprotkb": "Manganese transporter SMF2", "protein_names_refseq": "divalent metal ion transporter SMF2", "tax_id": 559292, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); Buruli ulcer disease (Disease Ontology:DOID:0050456); inflammatory bowel disease (Disease Ontology:DOID:0050589); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); Parkinsonism (Disease Ontology:DOID:0080855); leprosy (Disease Ontology:DOID:1024); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoidosis (Disease Ontology:DOID:11335); iron deficiency anemia (Disease Ontology:DOID:11758); hypochromic anemia (Disease Ontology:DOID:11759); Behcet's disease (Disease Ontology:DOID:13241); Parkinson's disease (Disease Ontology:DOID:14330); duodenal ulcer (Disease Ontology:DOID:1724); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary tuberculosis (Disease Ontology:DOID:2957); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); pneumonia (Disease Ontology:DOID:552); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); visceral leishmaniasis (Disease Ontology:DOID:9146); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (sce:YHR050W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10930410;11027260;12923174;1447206;24374639;33481703;33491328;8091229", "class_list": "", "function": "High-affinity manganese transporter involved in manganese uptake from the extracellular environment., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DKZ8", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0046872 metal ion binding;GO:0005384 manganese ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005770 late endosome;GO:0005802 trans-Golgi network;GO:0005775 vacuolar lumen", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0006828 manganese ion transport;GO:0030026 intracellular manganese ion homeostasis;GO:0006824 cobalt ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P38778-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38781-1", "uniprot_id": "RSC30_YEAST", "mass": 101335.0, "length": 883, "protein_name": "Chromatin structure-remodeling complex protein RSC30", "gene_name": "RSC30", "organism": "Yeast", "refseq_name": "Rsc30p", "refseq_ac": "NP_011923", "gene_names_uniprotkb": "RSC30", "gene_names_refseq": "RSC30", "protein_names_uniprotkb": "Chromatin structure-remodeling complex protein RSC30; Remodel the structure of chromatin complex subunit 30", "protein_names_refseq": "Rsc30p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR056C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10025404;10329629;10619019;11336698;12072455;12183366;12697820;16204215;17330950;17563356;18407956;19779198;20190278;20702584;21126336;21177495;22814378;23749301;24374639;30516470;32597660;33481703;33491328;8091229;8980231", "class_list": "", "function": "Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is required for transcription of ribosomal protein genes and genes involved in the integrity of the cell wall. Together with HTL1, LDB7, NPL6, RSC3 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL05", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0016586 RSC-type complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38781-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38786-1", "uniprot_id": "RPP1_YEAST", "mass": 32224.0, "length": 293, "protein_name": "Ribonuclease P/MRP protein subunit RPP1", "gene_name": "RPP1", "organism": "Yeast", "refseq_name": "RNA-binding RNA processing protein RPP1", "refseq_ac": "NP_011929", "gene_names_uniprotkb": "RPP1", "gene_names_refseq": "RPP1", "protein_names_uniprotkb": "Ribonuclease P/MRP protein subunit RPP1; 3.1.26.5; RNA-processing protein RPP1; RNaseP/MRP 32.2 kDa subunit", "protein_names_refseq": "RNA-binding RNA processing protein RPP1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR062C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "14562095;14562106;14690591;14729943;15637077;18713869;23700311;24374639;30262633;32586950;32651392;33491328;8091229;9308968;9620854", "class_list": "", "function": "Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9308968, PubMed:9620854). RNase P is also involved in maturation of intron-encoded box C/D small nucleolar RNAs (PubMed:18713869). Component of RNase MRP, a site-specific endoribonuclease involved in the maturation of rRNA and the regulation of the cell cycle. RNase MRP cleaves pre-rRNA sequences as part of ribosome assembly (PubMed:9308968, PubMed:9620854). RNase MRP also cleaves CLB2 mRNA in its 5'-UTR to allow rapid 5' to 3' degradation by the Xrn1 nuclease, required for exit from mitosis (PubMed:14729943)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL11", "ec_number_list": "2.1.1.309;2.7.11.1;3.1.26.5;3.1.-.-;3.6.1.-", "go_molecular_function": "GO:0003723 RNA binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38786-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38792-1", "uniprot_id": "RRP4_YEAST", "mass": 39427.0, "length": 359, "protein_name": "Exosome complex component RRP4", "gene_name": "RRP4", "organism": "Yeast", "refseq_name": "exosome non-catalytic core subunit RRP4", "refseq_ac": "NP_011936", "gene_names_uniprotkb": "RRP4", "gene_names_refseq": "RRP4", "protein_names_uniprotkb": "Exosome complex component RRP4; Ribosomal RNA-processing protein 4", "protein_names_refseq": "exosome non-catalytic core subunit RRP4", "tax_id": 559292, "disease": "short stature, hearing loss, retinitis pigmentosa, and distinctive facies (Disease Ontology:DOID:0081175); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (sce:YHR069C); (R-SCE-429958); (R-SCE-450385); (R-SCE-450513); (R-SCE-6791226)", "pathway_count": 5, "publication_count": 24, "publication_id_list": "10465791;12972615;14562095;14562106;16829593;17173052;17174896;18407956;19060898;19779198;19795423;19823750;21126336;21725298;22814378;23749301;24374639;30181345;32597660;33481703;33491328;8091229;8600032;9390555", "class_list": "", "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP4 as peripheral part of the Exo-9 complex is thought to stabilize the hexameric ring of RNase PH-domain subunits., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL18", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000176 nuclear exosome (RNase complex);GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006396 RNA processing;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006401 RNA catabolic process;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P38792-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38793-1", "uniprot_id": "TRM5_YEAST", "mass": 56514.0, "length": 499, "protein_name": "tRNA (guanine(37)-N(1))-methyltransferase", "gene_name": "TRM5", "organism": "Yeast", "refseq_name": "tRNA (guanine) methyltransferase", "refseq_ac": "NP_011937", "gene_names_uniprotkb": "TRM5", "gene_names_refseq": "TRM5", "protein_names_uniprotkb": "tRNA (guanine(37)-N(1))-methyltransferase; 2.1.1.228; M1G-methyltransferase; tRNA [GM37] methyltransferase; tRNA methyltransferase 5", "protein_names_refseq": "tRNA (guanine) methyltransferase", "tax_id": 559292, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); combined oxidative phosphorylation deficiency 26 (Disease Ontology:DOID:0111490); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); hypercalcemia (Disease Ontology:DOID:12678); lactic acidosis (Disease Ontology:DOID:3650); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (sce:YHR070W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11226173;14562095;14562106;17652090;18982304;21670254;24374639;33229814;33481703;33491328;8091229", "class_list": "", "function": "Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Postspliced cytoplasmic tRNAs are imported into the nucleus, where this first step seems to take place, after which they are reexported to the cytoplasm, where the yW sythesis is completed by cytoplasmic enzymes., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D3DL19", "ec_number_list": "2.1.1.228", "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006400 tRNA modification;GO:0002939 tRNA N1-guanine methylation;GO:0070901 mitochondrial tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38793-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38798-1", "uniprot_id": "NMD2_YEAST", "mass": 126747.0, "length": 1089, "protein_name": "Nonsense-mediated mRNA decay protein 2", "gene_name": "NMD2", "organism": "Yeast", "refseq_name": "Nmd2p", "refseq_ac": "NP_011944", "gene_names_uniprotkb": "NMD2; IFS1; SUA1; UPF2", "gene_names_refseq": "IFS1; NMD2; SUA1; SUP111; UPF2", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay protein 2; Up-frameshift suppressor 2", "protein_names_refseq": "Nmd2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR077C); (R-SCE-975957)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562106;16611983;24374639;32597660;33491328;7604038;7883167;7883168;8091229;8816461", "class_list": "", "function": "Involved in nonsense-mediated decay of mRNAs containing premature stop codons. It interacts, via its C-terminus, with NAM7/UPF1 (PubMed:8816461). Could be involved in determining the efficiency of translational termination or reinitiation or factors involved in the initial assembly of an initiation- and termination-competent mRNP., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL27", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0006310 DNA recombination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0071026 cytoplasmic RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38798-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38800-1", "uniprot_id": "LAM4_YEAST", "mass": 149680.0, "length": 1345, "protein_name": "Membrane-anchored lipid-binding protein LAM4", "gene_name": "LAM4", "organism": "Yeast", "refseq_name": "Lam4p", "refseq_ac": "NP_011948", "gene_names_uniprotkb": "LAM4; LTC3", "gene_names_refseq": "LAM4; LTC3", "protein_names_uniprotkb": "Membrane-anchored lipid-binding protein LAM4; Lipid transfer at contact site protein 3; Lipid transfer protein anchored at membrane contact sites 1", "protein_names_refseq": "Lam4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR080C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "17330950;18407956;19779198;19795423;19823750;21177495;23749301;24374639;25987606;26001273;29927351;32597660;33481703;33491328;8091229", "class_list": "", "function": "May be involved in sterol transfer between intracellular membranes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL31", "ec_number_list": "", "go_molecular_function": "GO:0032934 sterol binding;GO:0120015 sterol transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0032366 intracellular sterol transport;GO:0015918 sterol transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38800-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38801-1", "uniprot_id": "LRP1_YEAST", "mass": 21045.0, "length": 184, "protein_name": "Exosome complex protein LRP1", "gene_name": "LRP1", "organism": "Yeast", "refseq_name": "Lrp1p", "refseq_ac": "NP_011949", "gene_names_uniprotkb": "LRP1; RRP47; YC1D", "gene_names_refseq": "LRP1; RRP47", "protein_names_uniprotkb": "Exosome complex protein LRP1; Like an rRNA processing protein 1; Yeast C1D domain-containing protein; rRNA processing protein 47", "protein_names_refseq": "Lrp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR081W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11914276;12421302;12837249;12972615;15161972;15489286;22814378;24374639;33481703;33491328;8091229", "class_list": "", "function": "Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites. Required for activity of RRP6 in 7S pre-rRNA processing. Also has a role in 3'-processing of U4 and U5 small nuclear RNAs (snRNAs). Acts as a mRNA export factor. Mediates mRNA degradation upon UV irradiation. Maintains genome integrity where it is involved in both non-homologous end joining (NHEJ) and homologous recombination pathway repair of double strand DNA breaks. During NHEJ, required for joining 3'-overhanging ends. Also involved in telomere length regulation and maintenance., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL32", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0044877 protein-containing complex binding;GO:0003690 double-stranded DNA binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000178 exosome (RNase complex)", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034476 U5 snRNA 3'-end processing;GO:0010468 regulation of gene expression;GO:0000460 maturation of 5.8S rRNA;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38801-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38803-1", "uniprot_id": "IPI1_YEAST", "mass": 37867.0, "length": 334, "protein_name": "Pre-rRNA-processing protein IPI1", "gene_name": "IPI1", "organism": "Yeast", "refseq_name": "Ipi1p", "refseq_ac": "NP_011953", "gene_names_uniprotkb": "IPI1", "gene_names_refseq": "IPI1", "protein_names_uniprotkb": "Pre-rRNA-processing protein IPI1; Involved in processing IST2 protein 1", "protein_names_refseq": "Ipi1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR085W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14562095;14562106;14690591;14759368;15260980;15528184;19779198;21177495;24374639;26619264;33481703;33491328;8091229", "class_list": "", "function": "Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL36", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0120330 rixosome complex", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P38803-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38806-1", "uniprot_id": "YNG2_YEAST", "mass": 32086.0, "length": 282, "protein_name": "Chromatin modification-related protein YNG2", "gene_name": "YNG2", "organism": "Yeast", "refseq_name": "histone acetyltransferase YNG2", "refseq_ac": "NP_011958", "gene_names_uniprotkb": "YNG2; EAF4; NBN1", "gene_names_refseq": "EAF4; NBN1; YNG2", "protein_names_uniprotkb": "Chromatin modification-related protein YNG2; ESA1-associated factor 4; ING1 homolog 2", "protein_names_refseq": "histone acetyltransferase YNG2", "tax_id": 559292, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YHR090C); (R-SCE-3899300); (R-SCE-6804758); (R-SCE-6811555)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "10805724;11544250;11604499;12417725;14562095;14690591;15045029;15353583;15485911;16728974;17563356;18407956;19779198;19795423;19823750;20489023;20702584;23749301;24374639;32597660;33481703;33491328;8091229", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL42", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0035267 NuA4 histone acetyltransferase complex;GO:0032777 piccolo histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P38806-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38810-1", "uniprot_id": "SFB3_YEAST", "mass": 103950.0, "length": 929, "protein_name": "SED5-binding protein 3", "gene_name": "SFB3", "organism": "Yeast", "refseq_name": "Sfb3p", "refseq_ac": "NP_011966", "gene_names_uniprotkb": "SFB3; LST1", "gene_names_refseq": "LST1; SFB3", "protein_names_uniprotkb": "SED5-binding protein 3; Lethal with SEC13 protein 1; SEC24-related protein 3", "protein_names_refseq": "Sfb3p", "tax_id": 559292, "disease": "Cole-Carpenter syndrome (Disease Ontology:DOID:0060438)", "pathway": " (sce:YHR098C); (R-SCE-204005); (R-SCE-5694530); (R-SCE-983170)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10330397;10753972;14562106;17261844;17330950;17563356;18407956;19779198;23749301;24374639;32597660;33481703;33491328;8091229", "class_list": "", "function": "Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL48", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005048 signal sequence binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071944 cell periphery;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38810-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38815-1", "uniprot_id": "YPT35_YEAST", "mass": 24646.0, "length": 214, "protein_name": "Endosomal/vacuolar adapter protein YPT35", "gene_name": "YPT35", "organism": "Yeast", "refseq_name": "Ypt35p", "refseq_ac": "NP_011973", "gene_names_uniprotkb": "YPT35", "gene_names_refseq": "YPT35", "protein_names_uniprotkb": "Endosomal/vacuolar adapter protein YPT35; PX domain-containing protein YPT35", "protein_names_refseq": "Ypt35p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR105W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11557775;14562095;15263065;17322287;19684113;19779198;21126336;21177495;23749301;24374639;30018089;30516470;32597660;33481703;33491328;8091229", "class_list": "", "function": "Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL55", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0005768 endosome;GO:0010008 endosome membrane;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0036010 protein localization to endosome;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38815-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38817-1", "uniprot_id": "GGA2_YEAST", "mass": 64347.0, "length": 585, "protein_name": "ADP-ribosylation factor-binding protein GGA2", "gene_name": "GGA2", "organism": "Yeast", "refseq_name": "phosphatidylinositol 4-phosphate-binding protein", "refseq_ac": "NP_011976", "gene_names_uniprotkb": "GGA2", "gene_names_refseq": "GGA2", "protein_names_uniprotkb": "ADP-ribosylation factor-binding protein GGA2; Golgi-localized, gamma ear-containing, ARF-binding protein 2", "protein_names_refseq": "phosphatidylinositol 4-phosphate-binding protein", "tax_id": 559292, "disease": "immunodeficiency 85 (Disease Ontology:DOID:0061055)", "pathway": " (sce:YHR108W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10747088;11124697;12483220;14562106;22106047;23749301;24374639;32597660;33481703;33491328;8091229", "class_list": "", "function": "May play a role in the regulation of membrane traffic through the trans-Golgi network., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL58", "ec_number_list": "", "go_molecular_function": "GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006895 Golgi to endosome transport;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38817-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38820-1", "uniprot_id": "UBA4_YEAST", "mass": 49361.0, "length": 440, "protein_name": "Adenylyltransferase and sulfurtransferase UBA4", "gene_name": "UBA4", "organism": "Yeast", "refseq_name": "Uba4p", "refseq_ac": "NP_011979", "gene_names_uniprotkb": "UBA4; NCS3", "gene_names_refseq": "UBA4; YHR1", "protein_names_uniprotkb": "Adenylyltransferase and sulfurtransferase UBA4; Needs CLA4 to survive protein 3; Ubiquitin-like protein activator 4", "protein_names_refseq": "Uba4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR111W); (R-SCE-947581)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10713047;14562095;14562106;18407956;18491921;18664566;18755837;19145231;19151091;22814378;23749301;24374639;33481703;33491328;8091229", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DL61", "ec_number_list": "", "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0034599 cellular response to oxidative stress;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38820-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38821-1", "uniprot_id": "DNPEP_YEAST", "mass": 54174.0, "length": 490, "protein_name": "Aspartyl aminopeptidase 4", "gene_name": "APE4", "organism": "Yeast", "refseq_name": "aspartyl aminopeptidase", "refseq_ac": "NP_011981", "gene_names_uniprotkb": "APE4", "gene_names_refseq": "APE4", "protein_names_uniprotkb": "Aspartyl aminopeptidase 4; 3.4.11.21", "protein_names_refseq": "aspartyl aminopeptidase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR113W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11914276;14562095;14562106;16367759;17651441;21343297;24374639;33491328;8091229", "class_list": "", "function": "Aspartyl aminopeptidase that contributes to peptide degradation both in the cytosol and the vacuole. Cells may respond to environmental conditions by changing the distributions of the cytosolic enzyme to the vacuole when cells need more active vacuolar degradation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL63", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000324 fungal-type vacuole;GO:0000328 fungal-type vacuole lumen", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38821-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38822-1", "uniprot_id": "BZZ1_YEAST", "mass": 71171.0, "length": 633, "protein_name": "Protein BZZ1", "gene_name": "BZZ1", "organism": "Yeast", "refseq_name": "Bzz1p", "refseq_ac": "NP_011982", "gene_names_uniprotkb": "BZZ1; LSB7", "gene_names_refseq": "BZZ1; LSB7", "protein_names_uniprotkb": "Protein BZZ1; LAS17-binding protein 7", "protein_names_refseq": "Bzz1p", "tax_id": 559292, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (sce:YHR114W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12391157;14562106;16231105;17322287;17563356;18407956;19779198;20702584;21126336;21177495;22218487;23749301;24374639;24909858;30516470;32597660;33481703;33491328;8091229", "class_list": "", "function": "Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL64;E9P8V2", "ec_number_list": "", "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030479 actin cortical patch;GO:0005935 cellular bud neck;GO:0043332 mating projection tip", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0009651 response to salt stress;GO:0045010 actin nucleation;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P38822-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38823-1", "uniprot_id": "DMA1_YEAST", "mass": 46098.0, "length": 416, "protein_name": "E3 ubiquitin-protein ligase DMA1", "gene_name": "DMA1", "organism": "Yeast", "refseq_name": "ubiquitin-conjugating protein DMA1", "refseq_ac": "NP_011983", "gene_names_uniprotkb": "DMA1; CHF1", "gene_names_refseq": "CHF1; DMA1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase DMA1; 2.3.2.27; Checkpoint forkhead associated with RING domains-containing protein 1; Defective in mitotic arrest protein 1; RING-type E3 ubiquitin transferase DMA1", "protein_names_refseq": "ubiquitin-conjugating protein DMA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR115C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;15146058;15319434;18202552;23264631;24374639;33491328;8091229", "class_list": "", "function": "E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes (PubMed:18202552). Involved in nutritional control of the cell cycle (PubMed:15319434). Targets the G1 cyclin PCL1 for destruction (PubMed:23264631). Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck (PubMed:15146058)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL65;Q66GT1", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex;GO:0032153 cell division site", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0000921 septin ring assembly;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38823-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38828-1", "uniprot_id": "LSM12_YEAST", "mass": 21314.0, "length": 187, "protein_name": "Protein LSM12", "gene_name": "LSM12", "organism": "Yeast", "refseq_name": "Lsm12p", "refseq_ac": "NP_011989", "gene_names_uniprotkb": "LSM12", "gene_names_refseq": "LSM12", "protein_names_uniprotkb": "Protein LSM12; Sm-like protein 12", "protein_names_refseq": "Lsm12p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR121W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;15225602;16702403;17322287;20471941;22814378;24374639;32597660;33481703;33491328;8091229", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL71", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38828-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38829-1", "uniprot_id": "YHS2_YEAST", "mass": 25675.0, "length": 231, "protein_name": "MIP18 family protein YHR122W", "gene_name": "", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "MIP18 family protein YHR122W", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR122W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;18439903;22814378;24374639;33481703;33491328;8091229", "class_list": "", "function": "May play a role in chromosome segregation through establishment of sister chromatid cohesion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL72", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0007059 chromosome segregation;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38829-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38830-1", "uniprot_id": "NDT80_YEAST", "mass": 71479.0, "length": 627, "protein_name": "Meiosis-specific transcription factor NDT80", "gene_name": "NDT80", "organism": "Yeast", "refseq_name": "transcription factor NDT80", "refseq_ac": "NP_011992", "gene_names_uniprotkb": "NDT80; DAS1", "gene_names_refseq": "NDT80", "protein_names_uniprotkb": "Meiosis-specific transcription factor NDT80", "protein_names_refseq": "transcription factor NDT80", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR124W)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "11035815;12192041;12242283;12384578;12411490;12783856;12832469;14605875;14680970;15161958;16531239;17322287;24374639;8091229;8524222;9660952;9742092", "class_list": "", "function": "Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL74;Q66R83", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0000228 nuclear chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0051321 meiotic cell cycle;GO:0043934 sporulation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38830-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38835-1", "uniprot_id": "YHT1_YEAST", "mass": 96099.0, "length": 850, "protein_name": "PH domain-containing protein YHR131C", "gene_name": "", "organism": "Yeast", "refseq_name": "uncharacterized protein", "refseq_ac": "NP_011999", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "PH domain-containing protein YHR131C", "protein_names_refseq": "uncharacterized protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR131C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12748633;14562095;14562106;18407956;19779198;20702584;23749301;24374639;32597660;33481703;33491328;34965436;8091229", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL79", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P38835-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38838-1", "uniprot_id": "WSS1_YEAST", "mass": 30627.0, "length": 269, "protein_name": "DNA-dependent metalloprotease WSS1", "gene_name": "WSS1", "organism": "Yeast", "refseq_name": "metalloendopeptidase WSS1", "refseq_ac": "NP_012002", "gene_names_uniprotkb": "WSS1", "gene_names_refseq": "WSS1", "protein_names_uniprotkb": "DNA-dependent metalloprotease WSS1; 3.4.24.-; DNA damage response protein WSS1; SUMO-dependent isopeptidase WSS1; Weak suppressor of SMT3 protein 1", "protein_names_refseq": "metalloendopeptidase WSS1", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR134W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11606525;11606770;15598824;18085829;18336552;20516210;24374639;24998930;33481703;8091229", "class_list": "", "function": "Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL83", "ec_number_list": "", "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0016925 protein sumoylation;GO:0019985 translesion synthesis;GO:1990414 replication-born double-strand break repair via sister chromatid exchange", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38838-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38840-1", "uniprot_id": "ARO9_YEAST", "mass": 58528.0, "length": 513, "protein_name": "Aromatic amino acid aminotransferase 2", "gene_name": "ARO9", "organism": "Yeast", "refseq_name": "aromatic-amino-acid:2-oxoglutarate transaminase", "refseq_ac": "NP_012005", "gene_names_uniprotkb": "ARO9", "gene_names_refseq": "ARO9", "protein_names_uniprotkb": "Aromatic amino acid aminotransferase 2; 2.6.1.57; 2.6.1.7; Aromatic amino acid aminotransferase II; Aromatic amino acid-requiring protein 9; KAT I; Kynurenine aminotransferase I", "protein_names_refseq": "aromatic-amino-acid:2-oxoglutarate transaminase", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR137W); (R-SCE-71064); (R-SCE-71240)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10207060;14562095;14562106;17330950;18407956;18625006;19779198;24374639;24909858;30516470;33481703;33491328;6763508;8091229;9491082;9491083", "class_list": "", "function": "General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways. Mainly involved in tryptophan degradation. Active with phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate and pyruvate as amino acceptors. Does not accept glutamate or 2-oxoglutarate as substrates. Also active with methionine, leucine, glutamine and kynurenine. Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) with pyruvate as amino acceptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL86;P87291", "ec_number_list": "2.6.1.7;2.6.1.57;2.6.1.39", "go_molecular_function": "GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0047536 2-aminoadipate transaminase activity;GO:0008793 aromatic-amino-acid transaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0006571 tyrosine biosynthetic process;GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0019509 L-methionine salvage from methylthioadenosine;GO:0009072 aromatic amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P38840-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38843-1", "uniprot_id": "CHS7_YEAST", "mass": 34898.0, "length": 316, "protein_name": "Chitin synthase export chaperone", "gene_name": "CHS7", "organism": "Yeast", "refseq_name": "Chs7p", "refseq_ac": "NP_012011", "gene_names_uniprotkb": "CHS7", "gene_names_refseq": "CHS7", "protein_names_uniprotkb": "Chitin synthase export chaperone", "protein_names_refseq": "Chs7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR142W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10366589;11895440;12237852;15623581;16818716;17322287;24374639;28346351;8091229", "class_list": "", "function": "Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL91", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005628 prospore membrane;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006457 protein folding;GO:0006031 chitin biosynthetic process;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38843-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38850-1", "uniprot_id": "RT107_YEAST", "mass": 123017.0, "length": 1070, "protein_name": "Regulator of Ty1 transposition protein 107", "gene_name": "RTT107", "organism": "Yeast", "refseq_name": "Rtt107p", "refseq_ac": "NP_012024", "gene_names_uniprotkb": "RTT107; ESC4", "gene_names_refseq": "ESC4; RTT107", "protein_names_uniprotkb": "Regulator of Ty1 transposition protein 107; Establishes silent chromatin protein 4", "protein_names_refseq": "Rtt107p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR154W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562095;14562106;14988729;16569515;17287358;17330950;17563356;17978089;18407956;19779198;19795423;19823750;20139071;20190278;20702584;22262834;23749301;24374639;32597660;33229814;33481703;33491328;8091229", "class_list": "", "function": "Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 45, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DLA3", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071944 cell periphery;GO:0090734 site of DNA damage;GO:0035361 Cul8-RING ubiquitin ligase complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006302 double-strand break repair;GO:0006334 nucleosome assembly;GO:1903775 regulation of DNA double-strand break processing;GO:0010526 transposable element silencing", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P38850-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38851-1", "uniprot_id": "LAM1_YEAST", "mass": 143584.0, "length": 1228, "protein_name": "Membrane-anchored lipid-binding protein LAM1", "gene_name": "LAM1", "organism": "Yeast", "refseq_name": "Lam1p", "refseq_ac": "NP_012025", "gene_names_uniprotkb": "LAM1; YSP1", "gene_names_refseq": "LAM1; YSP1", "protein_names_uniprotkb": "Membrane-anchored lipid-binding protein LAM1; Lipid transfer protein anchored at membrane contact sites 1; Yeast suicide protein 1", "protein_names_refseq": "Lam1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR155W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562095;14562106;15023338;15657396;18800175;23749301;24374639;26001273;32597660;33481703;33491328;8091229", "class_list": "", "function": "Involved in mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone (PubMed:15657396, PubMed:18800175). May be involved in sterol transfer between intracellular membranes (PubMed:26001273)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLA4", "ec_number_list": "", "go_molecular_function": "GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0032366 intracellular sterol transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38851-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38855-1", "uniprot_id": "PEX18_YEAST", "mass": 32037.0, "length": 283, "protein_name": "Peroxisomal membrane protein PEX18", "gene_name": "PEX18", "organism": "Yeast", "refseq_name": "Pex18p", "refseq_ac": "NP_012030", "gene_names_uniprotkb": "PEX18", "gene_names_refseq": "PEX18", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX18; Peroxin-18", "protein_names_refseq": "Pex18p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR160C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11590152;11606420;12167700;15456864;19795423;19823750;24374639;33491328;8091229;9864360", "class_list": "", "function": "Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2 (PubMed:12167700, PubMed:15456864, PubMed:9864360). Required for peroxisomal targeting of PEX7 and growth on oleate (PubMed:12167700, PubMed:15456864, PubMed:9864360)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLA9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol", "go_biological_process": "GO:0016558 protein import into peroxisome matrix", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38855-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38863-1", "uniprot_id": "SPC97_YEAST", "mass": 96825.0, "length": 823, "protein_name": "Spindle pole body component SPC97", "gene_name": "SPC97", "organism": "Yeast", "refseq_name": "gamma-tubulin-complex subunit SPC97", "refseq_ac": "NP_012042", "gene_names_uniprotkb": "SPC97", "gene_names_refseq": "SPC97", "protein_names_uniprotkb": "Spindle pole body component SPC97", "protein_names_refseq": "gamma-tubulin-complex subunit SPC97", "tax_id": 559292, "disease": "complex cortical dysplasia with other brain malformations 15 (Disease Ontology:DOID:0081266)", "pathway": " (sce:YHR172W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "14562106;18407956;21573187;22814378;23749301;24374639;29903865;30516470;33491328;8091229;9130700;9670012", "class_list": "", "function": "Involved in microtubule organization by the microtubule organizing center, the spindle pole body (SPB). Probably part of the microtubule attachment site at the SPB., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLC1", "ec_number_list": "", "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0008275 gamma-tubulin small complex;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005874 microtubule;GO:0000930 gamma-tubulin complex", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38863-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38869-1", "uniprot_id": "SVP26_YEAST", "mass": 26284.0, "length": 228, "protein_name": "Protein SVP26", "gene_name": "SVP26", "organism": "Yeast", "refseq_name": "Svp26p", "refseq_ac": "NP_012051", "gene_names_uniprotkb": "SVP26", "gene_names_refseq": "ERV26; SVP26", "protein_names_uniprotkb": "Protein SVP26; Sed5 compartment vesicle protein of 26 kDa", "protein_names_refseq": "Svp26p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR181W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562095;14562106;16107716;16847258;20236934;24374639;8091229", "class_list": "", "function": "Plays a role in retention of a subset of membrane proteins in the early Golgi compartments. Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLC9", "ec_number_list": "", "go_molecular_function": "GO:0097020 COPII receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0090110 COPII-coated vesicle cargo loading;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38869-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38870-1", "uniprot_id": "RGD3_YEAST", "mass": 90109.0, "length": 785, "protein_name": "Rho-GTPase-activating protein RGD3", "gene_name": "RGD3", "organism": "Yeast", "refseq_name": "Rgd3p", "refseq_ac": "NP_012052", "gene_names_uniprotkb": "RGD3", "gene_names_refseq": "RGD3", "protein_names_uniprotkb": "Rho-GTPase-activating protein RGD3", "protein_names_refseq": "Rgd3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR182W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562106;18407956;19779198;21177495;22814378;22842922;23749301;24374639;30516470;32597660;32941095;33481703;33491328;8091229", "class_list": "", "function": "GTPase activating protein (GAP) for RHO3 and CDC42 that binds membranes through phosphatidylinositol 4,5-bisphosphate (PubMed:32941095). Plays a key role in cell polarity (PubMed:32941095). Modulates the RHO3 distribution at the plasma membrane and its polarity during growth (PubMed:32941095)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLD0", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007264 small GTPase-mediated signal transduction;GO:0030010 establishment of cell polarity;GO:0007163 establishment or maintenance of cell polarity;GO:0031106 septin ring organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38870-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38875-1", "uniprot_id": "GPI16_YEAST", "mass": 68771.0, "length": 610, "protein_name": "GPI transamidase component GPI16", "gene_name": "GPI16", "organism": "Yeast", "refseq_name": "GPI-anchor transamidase subunit GPI16", "refseq_ac": "NP_012058", "gene_names_uniprotkb": "GPI16", "gene_names_refseq": "GPI16", "protein_names_uniprotkb": "GPI transamidase component GPI16", "protein_names_refseq": "GPI-anchor transamidase subunit GPI16", "tax_id": 559292, "disease": "paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); multiple congenital anomalies-hypotonia-seizures syndrome 3 (Disease Ontology:DOID:0080140)", "pathway": " (sce:YHR188C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11483512;11598210;14562106;24374639;8091229", "class_list": "", "function": "Component of the GPI transamidase complex. Involved in transfer of GPI to proteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DLD6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38875-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38877-1", "uniprot_id": "CTF8_YEAST", "mass": 15169.0, "length": 133, "protein_name": "Chromosome transmission fidelity protein 8", "gene_name": "CTF8", "organism": "Yeast", "refseq_name": "Ctf8p", "refseq_ac": "NP_012061", "gene_names_uniprotkb": "CTF8", "gene_names_refseq": "CTF8", "protein_names_uniprotkb": "Chromosome transmission fidelity protein 8", "protein_names_refseq": "Ctf8p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR191C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11389843;15964801;17322287;24374639;33491328;8091229", "class_list": "", "function": "Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLD9", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0006260 DNA replication;GO:0007064 mitotic sister chromatid cohesion;GO:0034398 telomere tethering at nuclear periphery;GO:0035753 maintenance of DNA trinucleotide repeats", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38877-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38878-1", "uniprot_id": "LNP_YEAST", "mass": 32063.0, "length": 278, "protein_name": "Endoplasmic reticulum junction formation protein lunapark", "gene_name": "LNP1", "organism": "Yeast", "refseq_name": "Lnp1p", "refseq_ac": "NP_012062", "gene_names_uniprotkb": "LNP1", "gene_names_refseq": "LNP1", "protein_names_uniprotkb": "Endoplasmic reticulum junction formation protein lunapark; ER junction formation factor lunapark", "protein_names_refseq": "Lnp1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR192W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;16847258;19779198;22729086;24374639;33491328;8091229", "class_list": "", "function": "Plays a role in tubular endoplasmic reticulum network formation and maintenance. Works in conjunction with the ER shaping proteins (reticulons RTN1 and RTN2, YOP1), and in antagonism to SEY1 to maintain the network in a dynamic equilibrium. May counterbalance SEY1-directed polygon formation by promoting polygon loss through ring closure., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLE0", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0071786 endoplasmic reticulum tubular network organization;GO:0034976 response to endoplasmic reticulum stress;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38878-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38881-1", "uniprot_id": "NVJ1_YEAST", "mass": 36421.0, "length": 321, "protein_name": "Nucleus-vacuole junction protein 1", "gene_name": "NVJ1", "organism": "Yeast", "refseq_name": "Nvj1p", "refseq_ac": "NP_012065", "gene_names_uniprotkb": "NVJ1; VAB36", "gene_names_refseq": "NVJ1; VAB36", "protein_names_uniprotkb": "Nucleus-vacuole junction protein 1", "protein_names_refseq": "Nvj1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR195W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10888680;12529432;14562095;14562106;15367582;15958487;16912077;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;28319008;28533415;32597660;33481703;33491328;8091229", "class_list": "", "function": "Involved in the formation of nucleus-vacuole junctions (NVJs) during piecemeal microautophagy of the nucleus (PMN) (PubMed:10888680, PubMed:12529432, PubMed:16912077). NVJs are interorganelle interfaces mediated by NVJ1 in the nuclear envelope and VAC8 on the vacuole membrane (PubMed:10888680, PubMed:12529432, PubMed:16912077). Together, NVJ1 and VAC8 form Velcro-like patches through which teardrop-like portions of the nucleus are pinched off into the vacuolar lumen and degraded by the PMN process (PubMed:10888680, PubMed:12529432, PubMed:16912077, PubMed:28533415). Also acts as an outer-nuclear membrane receptor for OSH1 and TSC13 (PubMed:15367582, PubMed:15958487, PubMed:16912077, PubMed:28319008)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLE3", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0071561 nucleus-vacuole junction;GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0034399 nuclear periphery;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008104 intracellular protein localization;GO:0034727 piecemeal microautophagy of the nucleus;GO:0071562 nucleus-vacuole junction assembly", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P38881-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38882-1", "uniprot_id": "UTP9_YEAST", "mass": 65271.0, "length": 575, "protein_name": "U3 small nucleolar RNA-associated protein 9", "gene_name": "UTP9", "organism": "Yeast", "refseq_name": "Utp9p", "refseq_ac": "NP_012066", "gene_names_uniprotkb": "UTP9", "gene_names_refseq": "UTP9", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 9; U three protein 9; U3 protein 9 required for transcription; U3 snoRNA-associated protein 9; t-UTP9", "protein_names_refseq": "Utp9p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR196W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12068309;14562106;14690591;15489292;18407956;23749301;24374639;30516470;33481703;33491328;8091229", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLE4", "ec_number_list": "", "go_molecular_function": "GO:0000049 tRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0033553 rDNA heterochromatin;GO:0034455 t-UTP complex;GO:0030686 90S preribosome", "go_biological_process": "GO:0071528 tRNA re-export from nucleus;GO:0006351 DNA-templated transcription;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38882-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38883-1", "uniprot_id": "RIX1_YEAST", "mass": 86739.0, "length": 763, "protein_name": "Pre-rRNA-processing protein RIX1", "gene_name": "RIX1", "organism": "Yeast", "refseq_name": "Rix1p", "refseq_ac": "NP_012067", "gene_names_uniprotkb": "RIX1; IPI2", "gene_names_refseq": "IPI2; RIX1", "protein_names_uniprotkb": "Pre-rRNA-processing protein RIX1; Involved in processing IST2 protein 2; Ribosomal export protein 1", "protein_names_refseq": "Rix1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR197W); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11313466;11583615;14562095;14562106;14690591;14759368;15260980;15528184;16978391;17287358;19779198;22814378;23749301;24374639;26619264;32597660;33481703;33491328;8091229", "class_list": "", "function": "Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits (PubMed:11313466, PubMed:14759368, PubMed:15528184, PubMed:26619264). Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:26619264)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLE5", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0120330 rixosome complex", "go_biological_process": "GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P38883-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38889-1", "uniprot_id": "SKN7_YEAST", "mass": 69202.0, "length": 622, "protein_name": "Transcription factor SKN7", "gene_name": "SKN7", "organism": "Yeast", "refseq_name": "kinase-regulated stress-responsive transcription factor SKN7", "refseq_ac": "NP_012076", "gene_names_uniprotkb": "SKN7; BRY1; POS9", "gene_names_refseq": "BRY1; POS9; SKN7", "protein_names_uniprotkb": "Transcription factor SKN7; Peroxide sensitivity protein 9", "protein_names_refseq": "kinase-regulated stress-responsive transcription factor SKN7", "tax_id": 559292, "disease": "cataract (Disease Ontology:DOID:83)", "pathway": " (sce:YHR206W)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10888672;14562106;14665464;17322287;18407956;23749301;24374639;33491328;7957083;8091229;8226633;8598053;9843501", "class_list": "", "function": "Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLF5;E9P959;P39747", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0000156 phosphorelay response regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0034599 cellular response to oxidative stress;GO:0006368 transcription elongation by RNA polymerase II;GO:0008361 regulation of cell size;GO:0000304 response to singlet oxygen", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P38889-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38891-1", "uniprot_id": "BCA1_YEAST", "mass": 43596.0, "length": 393, "protein_name": "Branched-chain-amino-acid aminotransferase, mitochondrial", "gene_name": "BAT1", "organism": "Yeast", "refseq_name": "branched-chain-amino-acid transaminase BAT1", "refseq_ac": "NP_012078", "gene_names_uniprotkb": "BAT1; ECA39; TWT1", "gene_names_refseq": "BAT1; ECA39; TWT1", "protein_names_uniprotkb": "Branched-chain-amino-acid aminotransferase, mitochondrial; 2.6.1.42; BCAT; Protein ECA39; Protein TWT1", "protein_names_refseq": "branched-chain-amino-acid transaminase BAT1", "tax_id": 559292, "disease": "hypervalinemia and hyperleucine-isoleucinemia (Disease Ontology:DOID:0060950); amino acid metabolic disorder (Disease Ontology:DOID:9252); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (sce:YHR208W); (R-SCE-70895)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "14562106;17322287;18407956;18625006;21267457;24374639;26659116;28912343;29037781;29850466;33481703;33491328;37497662;8091229;8692959;8702755;8798704;8934531", "class_list": "", "function": "Mitochondrial isozyme of branched-chain-amino-acid aminotransferase, involved in the biosynthesis of the branched chain amino acids (BCAAs) leucine, isoleucine, and valine (PubMed:21267457, PubMed:8702755, PubMed:8798704). Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using BCAAs (leucine, isoleucine, and valine) as the amino donors (PubMed:18625006). Appears to be involved in the regulation of the cell cycle, although this may be indirect via metabolic changes (PubMed:29850466, PubMed:37497662). Connects BCAAs and TCA-cycle metabolism governing TCA-cycle flux to activate TORC1 signaling (PubMed:26659116, PubMed:37497662). High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1 (PubMed:8798704)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLF7", "ec_number_list": "2.6.1.42", "go_molecular_function": "GO:0004084 branched-chain-amino-acid transaminase activity;GO:0052654 L-leucine-2-oxoglutarate transaminase activity;GO:0052655 L-valine-2-oxoglutarate transaminase activity;GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity;GO:0010326 methionine-oxo-acid transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0019509 L-methionine salvage from methylthioadenosine;GO:0009082 branched-chain amino acid biosynthetic process;GO:0009098 L-leucine biosynthetic process;GO:0009099 L-valine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P38891-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38894-1", "uniprot_id": "FLO5_YEAST", "mass": 111982.0, "length": 1075, "protein_name": "Flocculation protein FLO5", "gene_name": "FLO5", "organism": "Yeast", "refseq_name": "flocculin FLO5", "refseq_ac": "NP_012081", "gene_names_uniprotkb": "FLO5", "gene_names_refseq": "FLO5", "protein_names_uniprotkb": "Flocculation protein FLO5; Flocculin-5", "protein_names_refseq": "flocculin FLO5", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR211W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12698276;16086015;16487349;21149680;24374639;7502576;7668043;8091229;9483793", "class_list": "", "function": "Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D3DLG0", "ec_number_list": "", "go_molecular_function": "GO:0005537 D-mannose binding", "go_cellular_component": "GO:0071944 cell periphery;GO:0009277 fungal-type cell wall;GO:0098552 side of membrane", "go_biological_process": "GO:0031589 cell-substrate adhesion;GO:0000128 flocculation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38894-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38903-1", "uniprot_id": "2A5D_YEAST", "mass": 85335.0, "length": 757, "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform", "gene_name": "RTS1", "organism": "Yeast", "refseq_name": "protein phosphatase 2A regulatory subunit RTS1", "refseq_ac": "NP_014657", "gene_names_uniprotkb": "RTS1; OR26.04; SCS1", "gene_names_refseq": "RTS1; SCS1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; PP2A, B subunit, B' delta isoform; Protein RTS1; Protein SCS1", "protein_names_refseq": "protein phosphatase 2A regulatory subunit RTS1", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 35 (Disease Ontology:DOID:0070065); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (sce:YOR014W); (R-SCE-198753); (R-SCE-202670); (R-SCE-389513); (R-SCE-6811558)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "14562106;15665377;17287358;17330950;17563356;18407956;19684113;19779198;21126336;21177495;22218487;23749301;24374639;32597660;33229814;33481703;33491328;7565713;8846889;9154823;9169874", "class_list": "", "function": "Multicopy suppressor of ROX3 and HSP60., [UniProtKB, PubMed]; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 26, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 26, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 26, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "D6W281", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0019888 protein phosphatase regulator activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000159 protein phosphatase type 2A complex;GO:0000776 kinetochore;GO:0005816 spindle pole body", "go_biological_process": "GO:0006281 DNA repair;GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0008104 intracellular protein localization;GO:2000786 positive regulation of autophagosome assembly;GO:0031134 sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "P38903-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38907-1", "uniprot_id": "CENPN_YEAST", "mass": 52672.0, "length": 458, "protein_name": "Inner kinetochore subunit CHL4", "gene_name": "CHL4", "organism": "Yeast", "refseq_name": "Chl4p", "refseq_ac": "NP_010540", "gene_names_uniprotkb": "CHL4; CTF17; MCM17; YD9320A.04", "gene_names_refseq": "CHL4; CTF17; MCM17", "protein_names_uniprotkb": "Inner kinetochore subunit CHL4; CENP-N homolog; Chromosome loss protein 4; Chromosome transmission fidelity protein 17; Constitutive centromere-associated network protein CHL4; Minichromosome maintenance protein 17", "protein_names_refseq": "Chl4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR254W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12408861;12589047;14562106;14690591;22561346;24075991;24374639;33481703;33491328;34308839;8243998;8316241;9169867;9339342", "class_list": "", "function": "Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSN4", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0071459 protein localization to chromosome, centromeric region;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P38907-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38910-1", "uniprot_id": "CH10_YEAST", "mass": 11372.0, "length": 106, "protein_name": "10 kDa heat shock protein, mitochondrial", "gene_name": "HSP10", "organism": "Yeast", "refseq_name": "Hsp10p", "refseq_ac": "NP_014663", "gene_names_uniprotkb": "HSP10; CPN10; OR26.10", "gene_names_refseq": "CPN10; HSP10", "protein_names_uniprotkb": "10 kDa heat shock protein, mitochondrial; 10 kDa chaperonin; HSP10", "protein_names_refseq": "Hsp10p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR020C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;17322287;18407956;19779198;21126336;22814378;23749301;24374639;32597660;33481703;33491328;7902576;7903252;7913473;9169874", "class_list": "", "function": "Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W286;E9P935", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045041 protein import into mitochondrial intermembrane space;GO:0006457 protein folding;GO:0042026 protein refolding;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38910-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38911-1", "uniprot_id": "FKBP3_YEAST", "mass": 46553.0, "length": 411, "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "FPR3", "organism": "Yeast", "refseq_name": "peptidylprolyl isomerase FPR3", "refseq_ac": "NP_013637", "gene_names_uniprotkb": "FPR3; NPI46", "gene_names_refseq": "FPR3; NPI46", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase; 5.2.1.8; FK506-binding nuclear protein; FKBP-70; Nucleolar proline isomerase; PPIase; Proline rotamase", "protein_names_refseq": "peptidylprolyl isomerase FPR3", "tax_id": 559292, "disease": "", "pathway": " (sce:YML074C)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "14562106;15358193;15686447;17322287;17330950;18407956;19684113;19779198;19795423;19823750;20489023;21177495;21725298;22814378;23749301;24374639;30516470;33481703;33491328;7525596;7559654;7925954;8051210;9148902;9169872", "class_list": "", "function": "Proline isomerase that belongs to an abundant class of enzymes that catalyze the cis-trans isomerization of X-Pro peptide bonds and can accelerate the refolding of proline-containing polypeptides (PubMed:7525596, PubMed:7925954, PubMed:8051210). Specifically binds nuclear localization sequences (PubMed:7925954). May be involved in the assembly or folding of ribosomal proteins (PubMed:8051210)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0K9", "ec_number_list": "5.2.1.8", "go_molecular_function": "GO:0005527 macrolide binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P38911-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38912-1", "uniprot_id": "IF1A_YEAST", "mass": 17435.0, "length": 153, "protein_name": "Eukaryotic translation initiation factor 1A", "gene_name": "TIF11", "organism": "Yeast", "refseq_name": "translation initiation complex factor eIF1A", "refseq_ac": "NP_013987", "gene_names_uniprotkb": "TIF11; YM8156.02C", "gene_names_refseq": "TIF11", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 1A; Eukaryotic translation initiation factor 4C; eIF-1A; eIF-4C", "protein_names_refseq": "translation initiation complex factor eIF1A", "tax_id": 559292, "disease": "uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (sce:YMR260C); (R-SCE-156827); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "12372297;14562106;17322287;18407956;19795423;19823750;22814378;24374639;32597660;33491328;7559407;9169872", "class_list": "", "function": "Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W086", "ec_number_list": "", "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043024 ribosomal small subunit binding;GO:0003725 double-stranded RNA binding;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex", "go_biological_process": "GO:0002188 translation reinitiation;GO:0006413 translational initiation;GO:0001731 formation of translation preinitiation complex;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0001677 formation of translation initiation ternary complex", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P38912-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38922-1", "uniprot_id": "HRB1_YEAST", "mass": 52142.0, "length": 454, "protein_name": "Serine/arginine (SR)-type shuttling mRNA binding protein HRB1", "gene_name": "HRB1", "organism": "Yeast", "refseq_name": "mRNA-binding protein", "refseq_ac": "NP_014394", "gene_names_uniprotkb": "HRB1; N2009; TOM34", "gene_names_refseq": "HRB1; TOM34", "protein_names_uniprotkb": "Serine/arginine (SR)-type shuttling mRNA binding protein HRB1; Hypothetical RNA-binding protein 1; Polyadenylate-binding protein HRB1; Protein TOM34", "protein_names_refseq": "mRNA-binding protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL004W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "14562095;14562106;14676199;14769921;17244705;17330950;17351133;17563356;18407956;19779198;20702584;21177495;23222640;23749301;24374639;24452287;26602689;30516470;32597660;33481703;33491328;33856219;37776379;7941739;7985421;8402262;9169873;9499403", "class_list": "", "function": "Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus (PubMed:14676199, PubMed:14769921, PubMed:24452287). Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded. On correctly spliced mRNAs, GBP2 and HRB1 recruit MEX67 to allow nuclear export. On faulty mRNAs, GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation (PubMed:24452287)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBM5;D6W1H3;Q06HN4", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0071028 nuclear mRNA surveillance", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P38922-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38925-1", "uniprot_id": "SMF1_YEAST", "mass": 63264.0, "length": 575, "protein_name": "Manganese transporter SMF1", "gene_name": "SMF1", "organism": "Yeast", "refseq_name": "divalent metal ion transporter SMF1", "refseq_ac": "NP_014519", "gene_names_uniprotkb": "SMF1; ESP1", "gene_names_refseq": "SBS1; SMF1", "protein_names_uniprotkb": "Manganese transporter SMF1", "protein_names_refseq": "divalent metal ion transporter SMF1", "tax_id": 559292, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); Buruli ulcer disease (Disease Ontology:DOID:0050456); inflammatory bowel disease (Disease Ontology:DOID:0050589); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); Parkinsonism (Disease Ontology:DOID:0080855); leprosy (Disease Ontology:DOID:1024); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoidosis (Disease Ontology:DOID:11335); iron deficiency anemia (Disease Ontology:DOID:11758); hypochromic anemia (Disease Ontology:DOID:11759); Behcet's disease (Disease Ontology:DOID:13241); Parkinson's disease (Disease Ontology:DOID:14330); duodenal ulcer (Disease Ontology:DOID:1724); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary tuberculosis (Disease Ontology:DOID:2957); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); pneumonia (Disease Ontology:DOID:552); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); visceral leishmaniasis (Disease Ontology:DOID:9146); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (sce:YOL122C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10930410;11027260;12923174;1447206;15665377;16847258;22106047;23749301;24374639;32597660;33481703;33491328;8643535;8896268;9169874", "class_list": "", "function": "High-affinity manganese transporter involved in manganese uptake from the extracellular environment. Also contributes to cellular accumulation of other divalent metal ions such as cadmium, cobalt, copper, iron and nickel., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1U6", "ec_number_list": "", "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015295 solute:proton symporter activity;GO:0005384 manganese ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006878 intracellular copper ion homeostasis;GO:0006879 intracellular iron ion homeostasis;GO:0006825 copper ion transport;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38925-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38929-1", "uniprot_id": "ATC2_YEAST", "mass": 130861.0, "length": 1173, "protein_name": "Calcium-transporting ATPase 2", "gene_name": "PMC1", "organism": "Yeast", "refseq_name": "calcium-transporting ATPase PMC1", "refseq_ac": "NP_011509", "gene_names_uniprotkb": "PMC1", "gene_names_refseq": "PMC1", "protein_names_uniprotkb": "Calcium-transporting ATPase 2; 7.2.2.10; Vacuolar Ca(2+)-ATPase", "protein_names_refseq": "calcium-transporting ATPase PMC1", "tax_id": 559292, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); autosomal dominant intellectual developmental disorder 66 (Disease Ontology:DOID:0061039); autosomal dominant nonsyndromic deafness 82 (Disease Ontology:DOID:0070603); X-linked spinocerebellar ataxia 1 (Disease Ontology:DOID:0111829); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); brain infarction (Disease Ontology:DOID:3454); dystonia (Disease Ontology:DOID:543); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (sce:YGL006W); (R-SCE-418359); (R-SCE-5578775); (R-SCE-936837)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "14562106;23749301;24374639;33491328;7507493;9169869", "class_list": "", "function": "This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VUD2", "ec_number_list": "7.2.2.10;1.6.2.4", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38929-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38934-1", "uniprot_id": "BFR1_YEAST", "mass": 54639.0, "length": 470, "protein_name": "Nuclear segregation protein BFR1", "gene_name": "BFR1", "organism": "Yeast", "refseq_name": "Bfr1p", "refseq_ac": "NP_014841", "gene_names_uniprotkb": "BFR1", "gene_names_refseq": "BFR1", "protein_names_uniprotkb": "Nuclear segregation protein BFR1; Brefeldin A resistance protein 1", "protein_names_refseq": "Bfr1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR198C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "14562106;15665377;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;24909858;30516470;32597660;33481703;33491328;795423;8070655;9169874", "class_list": "", "function": "Implicated in secretion, nuclear segregation and in maintenance of cell size., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2Q7", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:1990904 ribonucleoprotein complex;GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0042149 cellular response to glucose starvation;GO:0007088 regulation of mitotic nuclear division;GO:0035269 protein O-linked glycosylation via mannose;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38934-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38954-1", "uniprot_id": "IPT1_YEAST", "mass": 60873.0, "length": 527, "protein_name": "Inositolphosphotransferase 1", "gene_name": "IPT1", "organism": "Yeast", "refseq_name": "inositolphosphotransferase", "refseq_ac": "NP_010357", "gene_names_uniprotkb": "IPT1; D4405; SYR4; YD8554.05C", "gene_names_refseq": "IPT1; KTI6; MIC2; SYR4", "protein_names_uniprotkb": "Inositolphosphotransferase 1; 2.7.1.228; Mannosyl diphosphorylinositol ceramide synthase", "protein_names_refseq": "inositolphosphotransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR072C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10931938;14562106;14583628;16847258;17322287;17563356;18407956;19779198;22322963;23749301;24374639;32597660;33481703;33491328;7483840;9169867;9368028", "class_list": "", "function": "Catalyzes the addition of a phosphorylinositol group onto mannosyl phosphorylinositol ceramide (MIPC) to form mannosyl diphosphorylinositol ceramide (M(IP)2C), the major sphingolipid in membranes of S.cerevisiae., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS58", "ec_number_list": "2.7.1.228", "go_molecular_function": "GO:0016772 transferase activity, transferring phosphorus-containing groups", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0070916 inositol phosphoceramide synthase complex", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0010507 negative regulation of autophagy;GO:0006676 mannosyl diphosphorylinositol ceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38954-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38961-1", "uniprot_id": "RRP8_YEAST", "mass": 45985.0, "length": 392, "protein_name": "25S rRNA (adenine(645)-N(1))-methyltransferase", "gene_name": "RRP8", "organism": "Yeast", "refseq_name": "25S rRNA (adenine645-N1)-methyltransferase", "refseq_ac": "NP_010368", "gene_names_uniprotkb": "RRP8; D4461", "gene_names_refseq": "RRP8", "protein_names_uniprotkb": "25S rRNA (adenine(645)-N(1))-methyltransferase; 2.1.1.287; Ribosomal RNA-processing protein 8", "protein_names_refseq": "25S rRNA (adenine645-N1)-methyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR083W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10864042;14562095;14562106;15161972;16552446;18407956;19779198;19795423;19823750;23180764;24374639;33481703;33491328;7483840;9169867", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 645 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Also involved in telomere length regulation and maintenance., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7LHG2", "ec_number_list": "2.1.1.287", "go_molecular_function": "GO:0016433 rRNA (adenine) methyltransferase activity;GO:0106142 rRNA (adenine-N1-)-methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031167 rRNA methylation;GO:0042273 ribosomal large subunit biogenesis;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P38961-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38967-1", "uniprot_id": "TAT2_YEAST", "mass": 65404.0, "length": 592, "protein_name": "Tryptophan permease", "gene_name": "TAT2", "organism": "Yeast", "refseq_name": "aromatic amino acid transmembrane transporter TAT2", "refseq_ac": "NP_014622", "gene_names_uniprotkb": "TAT2; LTG3; SAB2; SCM2; TAP2", "gene_names_refseq": "HPG2; LTG3; SAB2; SCM2; TAP2; TAT2", "protein_names_uniprotkb": "Tryptophan permease; Tryptophan amino acid transporter", "protein_names_refseq": "aromatic amino acid transmembrane transporter TAT2", "tax_id": 559292, "disease": "", "pathway": " (sce:YOL020W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10467005;10654085;14562106;16847258;24374639;33481703;33491328;7523855;8058037;9169874", "class_list": "", "function": "Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W245", "ec_number_list": "", "go_molecular_function": "GO:0003824 catalytic activity;GO:0015171 amino acid transmembrane transporter activity;GO:0015173 aromatic amino acid transmembrane transporter activity;GO:0005300 high-affinity tryptophan transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0044853 plasma membrane raft;GO:0032126 eisosome", "go_biological_process": "GO:0015827 tryptophan transport;GO:0003333 amino acid transmembrane transport;GO:0015801 aromatic amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P38967-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38970-1", "uniprot_id": "HAL5_YEAST", "mass": 95455.0, "length": 855, "protein_name": "Serine/threonine-protein kinase HAL5", "gene_name": "HAL5", "organism": "Yeast", "refseq_name": "protein kinase HAL5", "refseq_ac": "NP_012370", "gene_names_uniprotkb": "HAL5; J0531", "gene_names_refseq": "HAL5", "protein_names_uniprotkb": "Serine/threonine-protein kinase HAL5; 2.7.11.1; Halotolerance protein 5", "protein_names_refseq": "protein kinase HAL5", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL165C); (R-SCE-176187); (R-SCE-5693616); (R-SCE-69601)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10207057;15126631;15665377;17287358;17330950;17548466;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;24909858;28270554;30516470;32597660;33229814;33481703;33491328;8641269", "class_list": "", "function": "Protein kinase involved in salt tolerance and pH sensitivity, probably by regulating plasma membrane potential and cation influx. Positively controls the TRK1-TRK2 potassium transport system in response to potassium starvation. Stabilizes TRK1 in the plasma membrane by preventing its vacuolar sorting and degradation. Also stabilizes other plasma membrane nutrient transporters like CAN1, FUR4 and HXT1. May itself be subject to regulation by ARL1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 44, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VW22", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;3.1.3.48;2.7.11.13;3.6.4.-;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0045807 positive regulation of endocytosis;GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P38970-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38990-1", "uniprot_id": "SAK1_YEAST", "mass": 126872.0, "length": 1142, "protein_name": "SNF1-activating kinase 1", "gene_name": "SAK1", "organism": "Yeast", "refseq_name": "serine/threonine protein kinase SAK1", "refseq_ac": "NP_011055", "gene_names_uniprotkb": "SAK1; PAK1; SYGP-ORF45", "gene_names_refseq": "PAK1; SAK1", "protein_names_uniprotkb": "SNF1-activating kinase 1; 2.7.11.1", "protein_names_refseq": "serine/threonine protein kinase SAK1", "tax_id": 559292, "disease": "", "pathway": " (sce:YER129W)", "pathway_count": 1, "publication_count": 34, "publication_id_list": "12748292;12847291;12906789;14562095;14562106;15340085;15665377;15824893;16201971;16607009;16847059;17287358;17330950;17438333;17563356;18407956;19284616;19779198;19795423;19823750;19880754;20489023;20702584;21126336;21216941;22140226;23749301;24374639;32597660;33481703;33491328;9020587;9169868;9341678", "class_list": "", "function": "Serine/threonine-protein kinase that phosphorylates SNF1, the catalytic subunit of the SNF1 kinase complex. Acts as an activator of the SNF1 kinase complex and controls its nuclear localization upon glucose and nitrogen depletion. Also required for SNF1 kinase activation under other stress conditions like alkaline pH or presence of cadmium., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 47, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM35", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0005979 regulation of glycogen biosynthetic process;GO:0090329 regulation of DNA-templated DNA replication;GO:0051726 regulation of cell cycle;GO:1900180 regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P38990-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38992-1", "uniprot_id": "SUR2_YEAST", "mass": 40734.0, "length": 349, "protein_name": "Sphingolipid C4-hydroxylase SUR2", "gene_name": "SUR2", "organism": "Yeast", "refseq_name": "sphingosine hydroxylase", "refseq_ac": "NP_010583", "gene_names_uniprotkb": "SUR2; D9740.8; SYR2", "gene_names_refseq": "SUR2; SYR2", "protein_names_uniprotkb": "Sphingolipid C4-hydroxylase SUR2; 1.-.-.-; Syringomycin response protein 2", "protein_names_refseq": "sphingosine hydroxylase", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR297W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14562106;24374639;36897280;8868422;9169867;9368039;9556590", "class_list": "", "function": "Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Catalyzes the conversion of sphinganine to phytosphingosine in sphingolipid biosynthesis. Involved in the response to syringomycin., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSS6", "ec_number_list": "1.-.-.-", "go_molecular_function": "GO:0005506 iron ion binding;GO:0042284 sphingolipid delta-4 desaturase activity;GO:0102772 sphingolipid C4-monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38992-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38993-1", "uniprot_id": "FET3_YEAST", "mass": 72360.0, "length": 636, "protein_name": "Iron transport multicopper oxidase FET3", "gene_name": "FET3", "organism": "Yeast", "refseq_name": "ferroxidase FET3", "refseq_ac": "NP_013774", "gene_names_uniprotkb": "FET3; YM9796.11", "gene_names_refseq": "FET3", "protein_names_uniprotkb": "Iron transport multicopper oxidase FET3; 1.16.3.1; 1.16.3.4; Cuproxidase FET3", "protein_names_refseq": "ferroxidase FET3", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR058W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10694398;11389633;12009907;14562106;14623105;16230618;16522632;17287358;19779198;21177495;22218487;24374639;32597660;33491328;7836366;8293473;9162052;9169872;9722559", "class_list": "", "function": "Iron transport multicopper ferroxidase required for Fe(2+) ion high affinity uptake. Required to oxidize Fe(2+) to Fe(3+), which is then transported into the cell via the ferric iron permease FTR1. Essential component of copper-dependent iron transport. Also has cuprous oxidase activity (PubMed:14623105)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "D6VZN2", "ec_number_list": "1.16.3.1;1.16.3.4", "go_molecular_function": "GO:0005507 copper ion binding;GO:0004322 ferroxidase activity;GO:0016724 oxidoreductase activity, acting on metal ions, oxygen as acceptor", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0033573 high-affinity iron permease complex;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006878 intracellular copper ion homeostasis;GO:0006879 intracellular iron ion homeostasis;GO:0046688 response to copper ion;GO:0098706 iron ion import across cell outer membrane", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P38993-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38994-1", "uniprot_id": "ITS3_YEAST", "mass": 89320.0, "length": 779, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase MSS4", "gene_name": "MSS4", "organism": "Yeast", "refseq_name": "1-phosphatidylinositol-4-phosphate 5-kinase", "refseq_ac": "NP_010494", "gene_names_uniprotkb": "MSS4; YD8142A.05", "gene_names_refseq": "MSS4", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase MSS4; 1-phosphatidylinositol 4-phosphate kinase; 2.7.1.68; Diphosphoinositide kinase; PIP5K", "protein_names_refseq": "1-phosphatidylinositol-4-phosphate 5-kinase", "tax_id": 559292, "disease": "lethal congenital contracture syndrome 3 (Disease Ontology:DOID:0060653); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YDR208W); (R-SCE-1660499); (R-SCE-6811555); (R-SCE-6811558); (R-SCE-8847453); (R-SCE-8856828)", "pathway_count": 6, "publication_count": 19, "publication_id_list": "17330950;17563356;18407956;19684113;19779198;20489023;20702584;21126336;21177495;22562153;23749301;24374639;32597660;33481703;33491328;34965436;8152413;9169867;9624178", "class_list": "", "function": "Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PubMed:9624178, PubMed:22562153). Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton (PubMed:8152413)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 42, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSI9", "ec_number_list": "2.7.12.2;5.2.1.8;2.7.1.68", "go_molecular_function": "GO:0005524 ATP binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0030866 cortical actin cytoskeleton organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0031321 ascospore-type prospore assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P38994-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38995-1", "uniprot_id": "ATU2_YEAST", "mass": 109829.0, "length": 1004, "protein_name": "Copper-transporting ATPase", "gene_name": "CCC2", "organism": "Yeast", "refseq_name": "Cu(2+)-transporting P-type ATPase CCC2", "refseq_ac": "NP_010556", "gene_names_uniprotkb": "CCC2; D9954.6", "gene_names_refseq": "CCC2", "protein_names_uniprotkb": "Copper-transporting ATPase; 7.2.2.8; Cu(2+)-ATPase", "protein_names_refseq": "Cu(2+)-transporting P-type ATPase CCC2", "tax_id": 559292, "disease": "X-linked distal spinal muscular atrophy 3 (Disease Ontology:DOID:0111196); occipital horn syndrome (Disease Ontology:DOID:0111272); Alzheimer's disease (Disease Ontology:DOID:10652); iron deficiency anemia (Disease Ontology:DOID:11758); spinal muscular atrophy (Disease Ontology:DOID:12377); Menkes disease (Disease Ontology:DOID:1838); renal adenoma (Disease Ontology:DOID:2697); cutis laxa (Disease Ontology:DOID:3144); breast carcinoma (Disease Ontology:DOID:3459); aortic aneurysm (Disease Ontology:DOID:3627); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); liver carcinoma (Disease Ontology:DOID:686); osteoarthritis (Disease Ontology:DOID:8398); Wilson disease (Disease Ontology:DOID:893); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (sce:YDR270W); (R-SCE-936837)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11083871;11327811;11500502;14993228;16732294;21163943;24374639;33491328;7708696;7785328;8670839;9083054;9169867;9323360;9325307;9346482;9520490", "class_list": "", "function": "Copper-transporting P-type ATPase necessary for the proper uptake of iron (PubMed:7785328). Required for export of copper from cytosol into extracytosolic compartment (PubMed:11327811, PubMed:16732294, PubMed:9083054, PubMed:9346482). Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles where they are acquired by the cell-surface iron transporter FET3 (PubMed:11327811, PubMed:14993228, PubMed:16732294, PubMed:7708696, PubMed:9083054, PubMed:9325307, PubMed:9346482, PubMed:9520490). Required the production of inositolphosphorylceramide D, probably by delivering copper to a yet to be identified enzyme (PubMed:9323360)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSQ3", "ec_number_list": "7.2.2.8", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005507 copper ion binding;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0043682 P-type divalent copper transporter activity", "go_cellular_component": "GO:0012510 trans-Golgi network transport vesicle membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0006825 copper ion transport;GO:0060003 copper ion export;GO:0055070 copper ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38995-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38996-1", "uniprot_id": "NAB3_YEAST", "mass": 90439.0, "length": 802, "protein_name": "Nuclear polyadenylated RNA-binding protein 3", "gene_name": "NAB3", "organism": "Yeast", "refseq_name": "Nab3p", "refseq_ac": "NP_015134", "gene_names_uniprotkb": "NAB3; HMD1", "gene_names_refseq": "HMD1; NAB3", "protein_names_uniprotkb": "Nuclear polyadenylated RNA-binding protein 3", "protein_names_refseq": "Nab3p", "tax_id": 559292, "disease": "autosomal dominant intellectual developmental disorder 74 (Disease Ontology:DOID:0061047); atherosclerosis (Disease Ontology:DOID:1936); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (sce:YPL190C); (R-SCE-72203)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;17287358;17330950;17563356;19779198;19795423;19823750;20702584;21126336;22218487;24374639;32597660;33481703;33491328;7476874;7962083;9169875", "class_list": "", "function": "May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing. Binds to poly(A)+ RNA. Appears to act in the maintenance of CLN3 mRNA levels., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3H8;Q07034", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0001068 transcription regulatory region RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0035649 Nrd1 complex", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0031124 mRNA 3'-end processing;GO:0042780 tRNA 3'-end processing;GO:0071034 CUT catabolic process;GO:0034472 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P38996-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P38998-1", "uniprot_id": "LYS1_YEAST", "mass": 41465.0, "length": 373, "protein_name": "Saccharopine dehydrogenase [NAD(+), L-lysine-forming]", "gene_name": "LYS1", "organism": "Yeast", "refseq_name": "saccharopine dehydrogenase (NAD+, L-lysine-forming)", "refseq_ac": "NP_012300", "gene_names_uniprotkb": "LYS1", "gene_names_refseq": "LYS1", "protein_names_uniprotkb": "Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; 1.5.1.7; Lysine--2-oxoglutarate reductase; SDH", "protein_names_refseq": "saccharopine dehydrogenase (NAD+, L-lysine-forming)", "tax_id": 559292, "disease": "", "pathway": " (sce:YIR034C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10077615;14562106;17002315;17854830;17939687;22243403;22814378;24374639;26928762;28928432;3123231;32597660;33481703;33491328;378997;418069;4287986;4318475;6769500;6771291;6985909;9169870", "class_list": "", "function": "Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysine biosynthesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVW5", "ec_number_list": "1.5.1.7", "go_molecular_function": "GO:0003729 mRNA binding;GO:0004753 saccharopine dehydrogenase activity;GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0016558 protein import into peroxisome matrix;GO:0009085 lysine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P38998-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39002-1", "uniprot_id": "LCF3_YEAST", "mass": 77947.0, "length": 694, "protein_name": "Long-chain-fatty-acid--CoA ligase 3", "gene_name": "FAA3", "organism": "Yeast", "refseq_name": "long-chain fatty acid-CoA ligase FAA3", "refseq_ac": "NP_012257", "gene_names_uniprotkb": "FAA3", "gene_names_refseq": "FAA3", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 3; 6.2.1.3; Fatty acid activator 3; Long-chain acyl-CoA synthetase 3", "protein_names_refseq": "long-chain fatty acid-CoA ligase FAA3", "tax_id": 559292, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); asthma (Disease Ontology:DOID:2841)", "pathway": " (sce:YIL009W); (R-SCE-434313); (R-SCE-75876)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "14562095;14562106;17322287;20489023;21126336;22814378;24374639;33491328;8027063;8206942;9169870", "class_list": "", "function": "Activates endogenous long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:8206942). Acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10 (PubMed:8206942)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVS1", "ec_number_list": "6.2.1.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0035336 long-chain fatty-acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P39002-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39003-1", "uniprot_id": "HXT6_YEAST", "mass": 62705.0, "length": 570, "protein_name": "High-affinity hexose transporter HXT6", "gene_name": "HXT6", "organism": "Yeast", "refseq_name": "hexose transporter HXT6", "refseq_ac": "NP_010630", "gene_names_uniprotkb": "HXT6; D9651.12", "gene_names_refseq": "HXT6", "protein_names_uniprotkb": "High-affinity hexose transporter HXT6", "protein_names_refseq": "hexose transporter HXT6", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR343C)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12872131;16847258;24374639;7651133;9169867", "class_list": "", "function": "High-affinity glucose transporter., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VSX4", "ec_number_list": "", "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0055085 transmembrane transport;GO:0008643 carbohydrate transport;GO:0008645 hexose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P39003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39004-1", "uniprot_id": "HXT7_YEAST", "mass": 62735.0, "length": 570, "protein_name": "High-affinity hexose transporter HXT7", "gene_name": "HXT7", "organism": "Yeast", "refseq_name": "hexose transporter HXT7", "refseq_ac": "NP_010629", "gene_names_uniprotkb": "HXT7; D9651.11", "gene_names_refseq": "HXT7", "protein_names_uniprotkb": "High-affinity hexose transporter HXT7", "protein_names_refseq": "hexose transporter HXT7", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR342C)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12872131;14562106;16847258;18407956;19779198;19795423;19823750;23749301;24374639;33491328;7651133;9169867", "class_list": "", "function": "High-affinity glucose transporter., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VSX3", "ec_number_list": "", "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0015578 mannose transmembrane transporter activity;GO:0005351 carbohydrate:proton symporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0015146 pentose transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0055085 transmembrane transport;GO:0008643 carbohydrate transport;GO:0008645 hexose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P39004-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39006-1", "uniprot_id": "PSD1_YEAST", "mass": 56595.0, "length": 500, "protein_name": "Phosphatidylserine decarboxylase proenzyme 1, mitochondrial", "gene_name": "PSD1", "organism": "Yeast", "refseq_name": "phosphatidylserine decarboxylase 1", "refseq_ac": "NP_014230", "gene_names_uniprotkb": "PSD1; N1692", "gene_names_refseq": "PSD1", "protein_names_uniprotkb": "Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; 4.1.1.65", "protein_names_refseq": "phosphatidylserine decarboxylase 1", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (sce:YNL169C)", "pathway_count": 1, "publication_count": 33, "publication_id_list": "11294902;14562095;14562106;14576278;17976194;18644857;19795423;19823750;20702584;22984266;23045528;23124206;23749301;24146988;24374639;25829489;28473294;29290583;3005242;30510114;30858161;30926815;33481703;33491328;33718843;34818062;6427211;8227017;8407984;8530379;8686380;9169873;9294443", "class_list": "", "function": "Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (PubMed:17976194, PubMed:23124206, PubMed:25829489, PubMed:29290583, PubMed:8227017, PubMed:8407984). Phosphatidylethanolamine formed in the mitochondria is exported to other membranes to fullfill their requirements for PtdEtn (PubMed:11294902, PubMed:29290583, PubMed:8530379). Required for normal mitochondrial morphology and proper mitochondrial fusion during yeast mating (PubMed:23045528). Involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (PubMed:34818062). Required for induction of mitophagy during nitrogen starvation (PubMed:30510114). Appears to play a specific role in supporting respiratory complex III activity (PubMed:30926815)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 27, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W113", "ec_number_list": "4.1.1.65", "go_molecular_function": "GO:0004609 phosphatidylserine decarboxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0010954 positive regulation of protein processing;GO:0006656 phosphatidylcholine biosynthetic process;GO:0016540 protein autoprocessing;GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P39006-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39011-1", "uniprot_id": "GDS1_YEAST", "mass": 70993.0, "length": 633, "protein_name": "GTPase-GDP dissociation stimulator BEM4", "gene_name": "BEM4", "organism": "Yeast", "refseq_name": "Bem4p", "refseq_ac": "NP_015164", "gene_names_uniprotkb": "BEM4; P2561; ROM7", "gene_names_refseq": "BEM4; ROM7", "protein_names_uniprotkb": "GTPase-GDP dissociation stimulator BEM4; Bud emergence protein 4", "protein_names_refseq": "Bem4p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPL161C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12665577;14562095;14562106;21126336;24374639;33491328;8754839;8754840;8948103;9169875", "class_list": "", "function": "Probably acts as a GEF (guanine nucleotide exchange factor) for the Rho family of small GTP-binding proteins (G proteins) that stimulates the dissociation of GDP to enable subsequent binding of GTP (By similarity). May also chaperone the processing and/or trafficking of small GTPases independently of GEF activity (By similarity). Involved in the control of polarized cell growth via CDC42-mediated signaling (PubMed:8754839). Involved in the control of cell-wall organization via RHO1-mediated signaling (PubMed:8754839, PubMed:8754840). May also function via RHO2 and RHO4 (PubMed:8754839)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3K7", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0030010 establishment of cell polarity;GO:0019236 response to pheromone;GO:1903338 regulation of cell wall organization or biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P39011-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39012-1", "uniprot_id": "GAA1_YEAST", "mass": 69221.0, "length": 614, "protein_name": "GPI transamidase component GAA1", "gene_name": "GAA1", "organism": "Yeast", "refseq_name": "GPI-anchor transamidase subunit GAA1", "refseq_ac": "NP_013189", "gene_names_uniprotkb": "GAA1; END2; L9449.4", "gene_names_refseq": "END2; GAA1", "protein_names_uniprotkb": "GPI transamidase component GAA1", "protein_names_refseq": "GPI-anchor transamidase subunit GAA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR088W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11598210;16847258;22814378;24374639;7730400;9169871", "class_list": "", "function": "Component of the GPI transamidase complex. Required for a terminal step of GPI anchor attachment onto proteins. Affects endocytosis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VY88", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P39012-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39073-1", "uniprot_id": "SSN3_YEAST", "mass": 62847.0, "length": 555, "protein_name": "Meiotic mRNA stability protein kinase SSN3", "gene_name": "SSN3", "organism": "Yeast", "refseq_name": "cyclin-dependent serine/threonine protein kinase SSN3", "refseq_ac": "NP_015283", "gene_names_uniprotkb": "SSN3; ARE1; CDK8; GIG2; SRB10; UME5", "gene_names_refseq": "CDK8; GIG2; NUT7; RYE5; SRB10; SSN3; SSX7; UME5; URR1", "protein_names_uniprotkb": "Meiotic mRNA stability protein kinase SSN3; 2.7.11.22; 2.7.11.23; Cyclin-dependent kinase 8; Suppressor of RNA polymerase B SRB10", "protein_names_refseq": "cyclin-dependent serine/threonine protein kinase SSN3", "tax_id": 559292, "disease": "developmental and epileptic encephalopathy 87 (Disease Ontology:DOID:0112221); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (sce:YPL042C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "10360183;11226276;11331604;11555651;12200444;12520306;14749387;14988503;15175151;15240822;15477388;15601835;15687503;16076843;16109375;16630888;19684113;24374639;33481703;33491328;33933450;7877695;8164691;9169875;9702190;9845373", "class_list": "", "function": "Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions. Phosphorylates GCN4, promoting its ubiquitin-mediated degradation, and MSN2, promoting its nuclear exclusion. Phosphorylates STE12, thereby promoting its degradation and inhibition of filamentous growth. Phosphorylates GAL4, and this phosphorylation is required for efficient galactose-inducible transcription. Also phosphorylates BDF1 and the TAF2 subunit of the TFIID complex., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3X1", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.23;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:0016592 mediator complex", "go_biological_process": "GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P39073-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39104-1", "uniprot_id": "PIK1_YEAST", "mass": 119923.0, "length": 1066, "protein_name": "Phosphatidylinositol 4-kinase PIK1", "gene_name": "PIK1", "organism": "Yeast", "refseq_name": "1-phosphatidylinositol 4-kinase", "refseq_ac": "NP_014132", "gene_names_uniprotkb": "PIK1; N0795", "gene_names_refseq": "PIK120; PIK1; PIK41", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase PIK1; 2.7.1.67; PI4-kinase; PtdIns-4-kinase", "protein_names_refseq": "1-phosphatidylinositol 4-kinase", "tax_id": 559292, "disease": "autosomal dominant nonsyndromic deafness 87 (Disease Ontology:DOID:0070606)", "pathway": " (sce:YNL267W); (R-SCE-1660514)", "pathway_count": 2, "publication_count": 28, "publication_id_list": "10559922;14562106;15665377;17287358;17330950;17563356;17720810;18407956;19779198;19795423;19823750;19898464;20489023;20702584;21126336;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;34965436;8194527;8248783;8740425;9169873", "class_list": "", "function": "Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate (PubMed:19898464, PubMed:8194527, PubMed:8248783). PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton (PubMed:8194527). Involved in the response to mating pheromone (PubMed:8248783)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 39, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "D6W0S7", "ec_number_list": "3.6.5.2;2.7.1.67;2.7.11.1", "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006897 endocytosis;GO:0050714 positive regulation of protein secretion;GO:0042998 positive regulation of Golgi to plasma membrane protein transport;GO:0048015 phosphatidylinositol-mediated signaling;GO:0006995 cellular response to nitrogen starvation", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P39104-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39105-1", "uniprot_id": "PLB1_YEAST", "mass": 71667.0, "length": 664, "protein_name": "Lysophospholipase 1", "gene_name": "PLB1", "organism": "Yeast", "refseq_name": "lysophospholipase", "refseq_ac": "NP_013721", "gene_names_uniprotkb": "PLB1; YM8270.10C", "gene_names_refseq": "PLB1", "protein_names_uniprotkb": "Lysophospholipase 1; 3.1.1.5; Phospholipase B 1", "protein_names_refseq": "lysophospholipase", "tax_id": 559292, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); brain ischemia (Disease Ontology:DOID:2316); papilloma (Disease Ontology:DOID:2615); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (sce:YMR008C); (R-SCE-111995); (R-SCE-1482788); (R-SCE-1482798); (R-SCE-1482801); (R-SCE-1482839); (R-SCE-1482922); (R-SCE-1482925); (R-SCE-1483115); (R-SCE-1483152); (R-SCE-1483166); (R-SCE-2142753); (R-SCE-418592); (R-SCE-432142); (R-SCE-6811436)", "pathway_count": 15, "publication_count": 9, "publication_id_list": "10231538;10383953;10497163;15588231;17322287;24374639;33491328;8051052;9169872", "class_list": "", "function": "Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase B and lysophospholipase activities. It also displays transacylase activity. Substrate preference is phosphatidylserine > phosphatidylinositol >> phosphatidylcholine > phosphatidylethanolamine (PubMed:10497163, PubMed:8051052). The substrate specificity is pH- and ion-dependent. In contrast with activities observed at optimum pH 3.5, the order of substrate preference at pH 5.5 is phosphatidylcholine = phosphatidylethanolamine >> phosphatidylinositol. Degrades predominantly phosphatidylcholine and to some extent phosphatidylinositol in vivo (PubMed:15588231)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 19, "predicted_n_glycosites": 19, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "D6VZI2;Q6B2E2", "ec_number_list": "2.7.11.24;3.1.1.3;3.1.1.5;3.1.1.-", "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0120560 phosphatidylserine lysophospholipase activity;GO:0120561 phosphatidylinositol lysophospholipase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0046475 glycerophospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P39105-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39112-1", "uniprot_id": "DSS1_YEAST", "mass": 110822.0, "length": 969, "protein_name": "Exoribonuclease II, mitochondrial", "gene_name": "DSS1", "organism": "Yeast", "refseq_name": "exoribonuclease II", "refseq_ac": "NP_014014", "gene_names_uniprotkb": "DSS1; MSU1; YM8021.13C", "gene_names_refseq": "DSS1; MSU1", "protein_names_uniprotkb": "Exoribonuclease II, mitochondrial; 3.1.13.1; Deletion of SUV3 suppressor 1; Mitochondrial biogenesis protein MSU1; RNase II; Ribonuclease II", "protein_names_refseq": "exoribonuclease II", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR287C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12426313;14562106;14576278;2061283;21126336;21177495;24374639;33491328;8590460;9169872;9829834", "class_list": "", "function": "Essential for mitochondrial biogenesis., [UniProtKB]; Required for intron-independent turnover and processing of mitochondrial RNA. Participates in 3' mtRNA processing where it hydrolyzes single-stranded RNA or partially double-stranded RNA with 3' single-stranded tails., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0B4", "ec_number_list": "", "go_molecular_function": "GO:0008859 exoribonuclease II activity;GO:0003723 RNA binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045025 mitochondrial degradosome", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0000957 mitochondrial RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P39112-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39516-1", "uniprot_id": "RS14B_YEAST", "mass": 14650.0, "length": 138, "protein_name": "Small ribosomal subunit protein uS11B", "gene_name": "RPS14B", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS11 RPS14B", "refseq_ac": "NP_012344", "gene_names_uniprotkb": "RPS14B; CRY2; J0354", "gene_names_refseq": "CRY2; RPS14B", "protein_names_uniprotkb": "Small ribosomal subunit protein uS11B; 40S ribosomal protein S14-B; RP59B", "protein_names_refseq": "40S ribosomal protein uS11 RPS14B", "tax_id": 559292, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); chromosome 5q deletion syndrome (Disease Ontology:DOID:0090016); anemia (Disease Ontology:DOID:2355)", "pathway": " (sce:YJL191W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 12, "publication_count": 13, "publication_id_list": "14562095;14562106;15590835;22096102;22814378;24374639;24524803;32597660;33491328;7754713;8293976;8641269;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS11 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW00", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P39516-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39518-1", "uniprot_id": "LCF2_YEAST", "mass": 83438.0, "length": 744, "protein_name": "Long-chain-fatty-acid--CoA ligase 2", "gene_name": "FAA2", "organism": "Yeast", "refseq_name": "medium-chain fatty acid-CoA ligase FAA2", "refseq_ac": "NP_010931", "gene_names_uniprotkb": "FAA2; FAM1", "gene_names_refseq": "FAA2; FAM1", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 2; 6.2.1.3; Fatty acid activator 2; Long-chain acyl-CoA synthetase 2", "protein_names_refseq": "medium-chain fatty acid-CoA ligase FAA2", "tax_id": 559292, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); congenital diarrhea (Disease Ontology:DOID:0060774); leukemia (Disease Ontology:DOID:1240); acute myeloid leukemia (Disease Ontology:DOID:9119); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YER015W); (R-SCE-2046105); (R-SCE-2046106); (R-SCE-75876)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "14562106;18407956;22493507;22814378;24374639;33491328;7988550;8027063;8206942;8670886;9169868", "class_list": "", "function": "Activates endogenous medium-chain (MCFA) and long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:8206942). Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated (PubMed:8206942). Is the main if not exclusive MCFA (octanoate, decanoate and laureate) acyl-CoA ligase. Required for efficient MCFA beta-oxidation inside peroxisomes. Facilitates the transport of MCFAs into peroxisomes by passive diffusion, by decreasing the intraorganellar MCFA concentration (PubMed:8670886). Also esterifies LCFAs in the peroxisome matrix. The LCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane (PubMed:22493507)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLR3", "ec_number_list": "6.2.1.3", "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0102391 decanoate-CoA ligase activity;GO:0031956 medium-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0042760 very long-chain fatty acid catabolic process;GO:0015910 long-chain fatty acid import into peroxisome;GO:0015916 fatty-acyl-CoA transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P39518-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39520-1", "uniprot_id": "IFH1_YEAST", "mass": 122492.0, "length": 1085, "protein_name": "Protein IFH1", "gene_name": "IFH1", "organism": "Yeast", "refseq_name": "Ifh1p", "refseq_ac": "NP_013324", "gene_names_uniprotkb": "IFH1; L8083.9; RRP3", "gene_names_refseq": "IFH1", "protein_names_uniprotkb": "Protein IFH1; Ribosomal RNA-processing protein 3", "protein_names_refseq": "Ifh1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR223C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;15616568;17287358;17563356;18407956;19779198;19795423;19823750;20702584;21177495;21480437;23749301;24035395;24374639;30516470;32597660;33481703;33491328;34965436;7785326;9169871", "class_list": "", "function": "Transcriptional coactivator that together with FHL1 regulates the expression of rRNA and ribosomal protein genes (PubMed:15616568, PubMed:7785326). Its activity is negatively regulated by environmental stress (PubMed:15616568)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYM3", "ec_number_list": "", "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0000781 chromosome, telomeric region;GO:0032545 CURI complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I;GO:0060962 regulation of ribosomal protein gene transcription by RNA polymerase II;GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P39520-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39521-1", "uniprot_id": "FKHL1_YEAST", "mass": 103502.0, "length": 936, "protein_name": "Pre-rRNA-processing protein FHL1", "gene_name": "FHL1", "organism": "Yeast", "refseq_name": "Fhl1p", "refseq_ac": "NP_015429", "gene_names_uniprotkb": "FHL1; P8283.15", "gene_names_refseq": "FHL1; SPP42", "protein_names_uniprotkb": "Pre-rRNA-processing protein FHL1", "protein_names_refseq": "Fhl1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YPR104C)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562106;15616568;15665377;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;22218487;23749301;24374639;30516470;32597660;33481703;33491328;8164651;9169875", "class_list": "", "function": "Acts as a transcriptional regulator that recruits coactivator IFH1 to the promoters of ribosomal protein genes (PubMed:15616568, PubMed:8164651). Recruited to ribosomal gene promoters by RAP1 (PubMed:15616568, PubMed:8164651)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4A2", "ec_number_list": "", "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001223 transcription coactivator binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II;GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P39521-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39522-1", "uniprot_id": "ILV3_YEAST", "mass": 62861.0, "length": 585, "protein_name": "Dihydroxy-acid dehydratase, mitochondrial", "gene_name": "ILV3", "organism": "Yeast", "refseq_name": "dihydroxy-acid dehydratase ILV3", "refseq_ac": "NP_012550", "gene_names_uniprotkb": "ILV3; J1450", "gene_names_refseq": "ILV3", "protein_names_uniprotkb": "Dihydroxy-acid dehydratase, mitochondrial; 4.2.1.9; DAD", "protein_names_refseq": "dihydroxy-acid dehydratase ILV3", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR016C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;16041576;19779198;20008079;21798060;21987576;22954227;23749301;24374639;25280745;26543501;27532773;28505306;30850698;31303893;32597660;33481703;33491328;33620449;8299945;8641269", "class_list": "", "function": "Dihydroxyacid dehydratase that catalyzes the third step in the common pathway leading to biosynthesis of branched-chain amino acids (PubMed:20008079, PubMed:21798060, PubMed:21987576, PubMed:22954227, PubMed:25280745, PubMed:26543501, PubMed:27532773, PubMed:28505306, PubMed:30850698, PubMed:31303893, PubMed:33620449, PubMed:8299945). Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively (PubMed:20008079, PubMed:27532773). Required for the synthesis of alpha-isopropylmalate which modulates the activity of LEU3 and subsequently regulates the expression of LEU1 (PubMed:20008079)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWJ2", "ec_number_list": "4.2.1.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0004160 dihydroxy-acid dehydratase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009082 branched-chain amino acid biosynthetic process;GO:0009099 L-valine biosynthetic process;GO:0009097 isoleucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P39522-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39523-1", "uniprot_id": "YM11_YEAST", "mass": 105914.0, "length": 943, "protein_name": "Uncharacterized protein YMR124W", "gene_name": "YM8564.06", "organism": "Yeast", "refseq_name": "", "refseq_ac": "", "gene_names_uniprotkb": "YM8564.06", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein YMR124W", "protein_names_refseq": "", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR124W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "14562106;17287358;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22218487;22814378;23273919;23749301;24374639;28270554;30516470;31208443;32597660;33229814;33481703;33491328;34965436;9169872", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 13, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 13, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 13, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 70, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "D6VZU7", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005935 cellular bud neck", "go_biological_process": "GO:0061163 endoplasmic reticulum polarization", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P39523-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39531-1", "uniprot_id": "RCY1_YEAST", "mass": 97471.0, "length": 840, "protein_name": "Recyclin-1", "gene_name": "RCY1", "organism": "Yeast", "refseq_name": "Rcy1p", "refseq_ac": "NP_012331", "gene_names_uniprotkb": "RCY1; J0318; J0320", "gene_names_refseq": "RCY1", "protein_names_uniprotkb": "Recyclin-1", "protein_names_refseq": "Rcy1p", "tax_id": 559292, "disease": "obstructive nephropathy (Disease Ontology:DOID:0070314)", "pathway": " (sce:YJL204C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10769031;11287615;14562106;17563356;18407956;19779198;23749301;24374639;30516470;33481703;33491328;7754713;8641269", "class_list": "", "function": "Involved in recycling plasma membrane proteins internalized by endocytosis. Required for recycling of the v-SNARE SNC1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVZ0;P39530;P87193", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0000145 exocyst", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0006887 exocytosis;GO:0032456 endocytic recycling;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P39531-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39533-1", "uniprot_id": "ACON2_YEAST", "mass": 86583.0, "length": 789, "protein_name": "Homocitrate dehydratase, mitochondrial", "gene_name": "ACO2", "organism": "Yeast", "refseq_name": "aconitate hydratase ACO2", "refseq_ac": "NP_012335", "gene_names_uniprotkb": "ACO2; J0327", "gene_names_refseq": "ACO2", "protein_names_uniprotkb": "Homocitrate dehydratase, mitochondrial; 4.2.1.-; Aconitase 2", "protein_names_refseq": "aconitate hydratase ACO2", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL200C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10224250;14562095;14562106;14576278;21126336;23106124;24374639;33491328;7754713;8641269", "class_list": "", "function": "Catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVZ3", "ec_number_list": "4.2.1.-", "go_molecular_function": "GO:0003994 aconitate hydratase activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0019878 lysine biosynthetic process via aminoadipic acid", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P39533-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39538-1", "uniprot_id": "UBP12_YEAST", "mass": 143192.0, "length": 1254, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 12", "gene_name": "UBP12", "organism": "Yeast", "refseq_name": "putative ubiquitin-specific protease UBP12", "refseq_ac": "NP_012338", "gene_names_uniprotkb": "UBP12; J0340", "gene_names_refseq": "UBP12", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 12; 3.4.19.12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-specific-processing protease 12", "protein_names_refseq": "putative ubiquitin-specific protease UBP12", "tax_id": 559292, "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (sce:YJL197W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;18407956;19779198;19795423;19823750;21126336;23317502;23749301;24374639;24440502;32597660;33481703;33491328;7754713;8641269", "class_list": "", "function": "Ubiquitin carboxyl-terminal hydrolase that recognizes ubiquitin chains that stabilize FZO1 and promote mitochondrial fusion. UBP12 deubiquitylates FZO1 only after oligomerization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVZ5", "ec_number_list": "", "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0006974 DNA damage response;GO:0010637 negative regulation of mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P39538-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39540-1", "uniprot_id": "ELO1_YEAST", "mass": 36234.0, "length": 310, "protein_name": "Fatty acid elongase 1", "gene_name": "ELO1", "organism": "Yeast", "refseq_name": "fatty acid elongase ELO1", "refseq_ac": "NP_012339", "gene_names_uniprotkb": "ELO1; J0343", "gene_names_refseq": "ELO1", "protein_names_uniprotkb": "Fatty acid elongase 1; 2.3.1.199; 3-keto acyl-CoA synthase ELO1; Elongation of fatty acids protein 1; Very-long-chain 3-oxoacyl-CoA synthase 1", "protein_names_refseq": "fatty acid elongase ELO1", "tax_id": 559292, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (sce:YJL196C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10850979;12684876;14562095;14562106;16847258;24374639;7754713;8641269;8702485;9546663", "class_list": "", "function": "Component of a microsomal membrane bound medium-chain fatty acid elongation system, which extends medium-chain-length fatty acids to long-chain fatty acids. Component of elongase I, which extends 12-16-carbon fatty acyl-CoAs such as lauroyl-CoA to 14-18-carbon fatty acids by incorporation of malonyl-CoA., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVZ6", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid;GO:0019367 fatty acid elongation, saturated fatty acid;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P39540-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39552-1", "uniprot_id": "MST28_YEAST", "mass": 27091.0, "length": 234, "protein_name": "Multicopy suppressor of SEC21 protein 28", "gene_name": "MST28", "organism": "Yeast", "refseq_name": "DUP240 family protein MST28", "refseq_ac": "NP_009419", "gene_names_uniprotkb": "MST28; FUN59", "gene_names_refseq": "MST28", "protein_names_uniprotkb": "Multicopy suppressor of SEC21 protein 28; DUP240 protein MST28", "protein_names_refseq": "DUP240 family protein MST28", "tax_id": 559292, "disease": "", "pathway": " (sce:YAR033W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12101299;12925749;18407956;19779198;21126336;23749301;24374639;33491328;7731988", "class_list": "", "function": "Involved in protein trafficking vesicle formation, probably by stabilizing of coatomer at the Golgi membrane and thus allowing the efficient formation of COPI coated vesicles., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPN3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0016050 vesicle organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P39552-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39676-1", "uniprot_id": "FHP_YEAST", "mass": 44646.0, "length": 399, "protein_name": "Flavohemoprotein", "gene_name": "YHB1", "organism": "Yeast", "refseq_name": "flavohemoglobin", "refseq_ac": "NP_011750", "gene_names_uniprotkb": "YHB1; G8572; YHB", "gene_names_refseq": "YHB1; YHB4", "protein_names_uniprotkb": "Flavohemoprotein; 1.14.12.17; Flavohemoglobin; Hemoglobin-like protein; NO oxygenase; NOD; Nitric oxide dioxygenase", "protein_names_refseq": "flavohemoglobin", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); retinal ischemia (Disease Ontology:DOID:12510); transient cerebral ischemia (Disease Ontology:DOID:224); encephalitis (Disease Ontology:DOID:9588)", "pathway": " (sce:YGR234W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10758168;10922365;14562106;1594608;17322287;18407956;22814378;23749301;24374639;33481703;33491328;7896850;8701610;8810268;9169869;9545281", "class_list": "", "function": "In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity., [UniProtKB]; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VV14;Q6B1W6;Q9C1R6", "ec_number_list": "1.14.12.17", "go_molecular_function": "GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0008941 nitric oxide dioxygenase NAD(P)H activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0009636 response to toxic substance;GO:0034599 cellular response to oxidative stress;GO:0071500 cellular response to nitrosative stress;GO:0046210 nitric oxide catabolic process;GO:0071218 cellular response to misfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P39676-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39685-1", "uniprot_id": "PO152_YEAST", "mass": 151653.0, "length": 1337, "protein_name": "Nucleoporin POM152", "gene_name": "POM152", "organism": "Yeast", "refseq_name": "Pom152p", "refseq_ac": "NP_013848", "gene_names_uniprotkb": "POM152; YM9553.05", "gene_names_refseq": "POM152", "protein_names_uniprotkb": "Nucleoporin POM152; Nuclear pore protein POM152; P150; Pore membrane protein POM152", "protein_names_refseq": "Pom152p", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR129W)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10684247;11352933;12791264;14562106;14574415;16847258;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;22031224;23749301;24374639;32597660;33481703;33491328;8138573;8682855;9169872;9988776", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. POM152 is important for the de novo assembly of NPCs., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VZV2", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0005635 nuclear envelope;GO:0005641 nuclear envelope lumen;GO:0005643 nuclear pore;GO:0005739 mitochondrion", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006606 protein import into nucleus;GO:0030474 spindle pole body duplication", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P39685-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39702-1", "uniprot_id": "VPS8_YEAST", "mass": 144962.0, "length": 1274, "protein_name": "Vacuolar protein sorting-associated protein 8", "gene_name": "VPS8", "organism": "Yeast", "refseq_name": "CORVET complex membrane-binding subunit VPS8", "refseq_ac": "NP_009399", "gene_names_uniprotkb": "VPS8; FUN15; VPT8", "gene_names_refseq": "FUN15; VPL8; VPS8; VPT8", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 8; Vacuolar protein-targeting protein 8", "protein_names_refseq": "CORVET complex membrane-binding subunit VPS8", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL002W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562106;18407956;21126336;22814378;24374639;33491328;7731988;7941740;8864656", "class_list": "", "function": "Required for localization and recycling of the CPY sorting receptor (VPS10) to the late-Golgi compartment. Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VPL4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031901 early endosome membrane;GO:0005770 late endosome;GO:0005795 Golgi stack;GO:0033263 CORVET complex", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0034058 endosomal vesicle fusion;GO:0032889 regulation of vacuole fusion, non-autophagic;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P39702-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39706-1", "uniprot_id": "SWD1_YEAST", "mass": 48655.0, "length": 426, "protein_name": "COMPASS component SWD1", "gene_name": "SWD1", "organism": "Yeast", "refseq_name": "COMPASS subunit protein SWD1", "refseq_ac": "NP_009403", "gene_names_uniprotkb": "SWD1; CPS50; FUN16; SAF49", "gene_names_refseq": "CPS50; FUN16; SAF49; SWD1", "protein_names_uniprotkb": "COMPASS component SWD1; Complex proteins associated with SET1 protein SWD1; Set1C component SWD1", "protein_names_refseq": "COMPASS subunit protein SWD1", "tax_id": 559292, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (sce:YAR003W); (R-SCE-9772755)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11687631;11742990;11752412;11805083;14562106;15282802;24374639;29071121;30100186;31922488;7731988;7941740", "class_list": "", "function": "Component of the Set1C/COMPASS complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation (PubMed:11742990, PubMed:11805083). COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face (PubMed:31922488). SWD1/CPS50 acts as an assembly and regulatory hub for COMPASS complex formation (PubMed:30100186). Serves as a highly utilized surface for COMPASS interaction with the nucleosome (PubMed:31922488)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPL8", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0048188 Set1C/COMPASS complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006355 regulation of DNA-templated transcription;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P39706-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39707-1", "uniprot_id": "SEN34_YEAST", "mass": 31313.0, "length": 275, "protein_name": "tRNA-splicing endonuclease subunit SEN34", "gene_name": "SEN34", "organism": "Yeast", "refseq_name": "tRNA splicing endonuclease subunit SEN34", "refseq_ac": "NP_009405", "gene_names_uniprotkb": "SEN34; FUN4", "gene_names_refseq": "FUN4; SEN34", "protein_names_uniprotkb": "tRNA-splicing endonuclease subunit SEN34; 4.6.1.16; Splicing endonuclease of 34 kDa; tRNA-intron endonuclease SEN34", "protein_names_refseq": "tRNA splicing endonuclease subunit SEN34", "tax_id": 559292, "disease": "pontocerebellar hypoplasia type 2C (Disease Ontology:DOID:0060269)", "pathway": " (sce:YAR008W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12925762;16823961;24374639;33229814;33491328;7731988;7941740;9200603", "class_list": "", "function": "Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VPM0", "ec_number_list": "", "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0000213 tRNA-intron lyase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0012505 endomembrane system;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0000379 tRNA-type intron splice site recognition and cleavage", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P39707-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39714-1", "uniprot_id": "BDH1_YEAST", "mass": 41582.0, "length": 382, "protein_name": "(R,R)-butanediol dehydrogenase", "gene_name": "BDH1", "organism": "Yeast", "refseq_name": "(R,R)-butanediol dehydrogenase", "refseq_ac": "NP_009341", "gene_names_uniprotkb": "BDH1; BDH; FUN49", "gene_names_refseq": "BDH1", "protein_names_uniprotkb": "(R,R)-butanediol dehydrogenase; 1.1.1.4", "protein_names_refseq": "(R,R)-butanediol dehydrogenase", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL060W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10938079;14562095;14562106;17322287;19779198;24374639;33491328;7731988", "class_list": "", "function": "NAD-dependent (R,R)-butanediol dehydrogenase which catalyzes oxidation of (R,R)-butane-2,3-diol to (3R)-acetoin, of meso-butanediol to (3S)-acetoin, and reduction of acetoin. Allows the use of 2,3-butanediol as an aerobic carbon source., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPF9;E9P8Z3", "ec_number_list": "1.1.1.4", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000721 (R,R)-butanediol dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006066 alcohol metabolic process;GO:0034079 butanediol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P39714-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39719-1", "uniprot_id": "FLC2_YEAST", "mass": 87469.0, "length": 783, "protein_name": "Flavin carrier protein 2", "gene_name": "FLC2", "organism": "Yeast", "refseq_name": "flavin adenine dinucleotide transporter FLC2", "refseq_ac": "NP_009348", "gene_names_uniprotkb": "FLC2", "gene_names_refseq": "FLC2", "protein_names_uniprotkb": "Flavin carrier protein 2; FAD transporter 2; TRP-like ion channel FLC2", "protein_names_refseq": "flavin adenine dinucleotide transporter FLC2", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL053W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "14562106;16717099;16847258;17330950;18407956;19779198;19795423;19823750;22218487;23749301;24374639;33481703;33491328;34965436;7642141;7731988", "class_list": "", "function": "May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D6VPG5;Q05165", "ec_number_list": "", "go_molecular_function": "GO:0015230 FAD transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0055085 transmembrane transport;GO:0030148 sphingolipid biosynthetic process;GO:0006457 protein folding;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P39719-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39720-1", "uniprot_id": "OAF1_YEAST", "mass": 118891.0, "length": 1047, "protein_name": "Oleate-activated transcription factor 1", "gene_name": "OAF1", "organism": "Yeast", "refseq_name": "oleate-activated transcription factor OAF1", "refseq_ac": "NP_009349", "gene_names_uniprotkb": "OAF1; FUN43; YAF1", "gene_names_refseq": "OAF1; YAF1", "protein_names_uniprotkb": "Oleate-activated transcription factor 1", "protein_names_refseq": "oleate-activated transcription factor OAF1", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL051W)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "10428786;11875433;12709061;12748633;14562106;17467953;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;23749301;24374639;32597660;33481703;33491328;34965436;7731988;8662598;8972187;9288897", "class_list": "", "function": "The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. OAF1 acts as the sensor for oleate and inhibits PIP2 activity under non-inducing conditions. Activity is repressed by glucose., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPG6", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0089716 Pip2-Oaf1 complex", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0006351 DNA-templated transcription;GO:0006631 fatty acid metabolic process;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P39720-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39722-1", "uniprot_id": "GEM1_YEAST", "mass": 75150.0, "length": 662, "protein_name": "Mitochondrial Rho GTPase 1", "gene_name": "GEM1", "organism": "Yeast", "refseq_name": "ERMES complex Ca(2+)-binding regulatory GTPase GEM1", "refseq_ac": "NP_009351", "gene_names_uniprotkb": "GEM1", "gene_names_refseq": "GEM1; GON1", "protein_names_uniprotkb": "Mitochondrial Rho GTPase 1; 3.6.5.-; GTPase EF-hand protein of mitochondria 1", "protein_names_refseq": "ERMES complex Ca(2+)-binding regulatory GTPase GEM1", "tax_id": 559292, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (sce:YAL048C); (R-SCE-9013419); (R-SCE-9013425)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10220001;15479738;16407407;16823961;23749301;24374639;33491328;7731988", "class_list": "", "function": "Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPG8", "ec_number_list": "3.6.5.-", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0032865 ERMES complex", "go_biological_process": "GO:0055091 phospholipid homeostasis;GO:0007264 small GTPase-mediated signal transduction;GO:0015886 heme transport;GO:0007005 mitochondrion organization;GO:0010821 regulation of mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P39722-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39723-1", "uniprot_id": "MBO1_YEAST", "mass": 72106.0, "length": 622, "protein_name": "Gamma tubulin complex adapter SPC72", "gene_name": "SPC72", "organism": "Yeast", "refseq_name": "gamma-tubulin complex subunit SPC72", "refseq_ac": "NP_009352", "gene_names_uniprotkb": "SPC72; FUN42; LDB4; SPI6", "gene_names_refseq": "LDB4; SPC72", "protein_names_uniprotkb": "Gamma tubulin complex adapter SPC72", "protein_names_refseq": "gamma-tubulin complex subunit SPC72", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL047C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10428957;14562095;14562106;17322287;17967947;18022565;18407956;19779198;19795423;19823750;23749301;24374639;32099015;32597660;33481703;33491328;7731988;9585415;9606209;9670012;9718373", "class_list": "", "function": "Spindle pole body (SPB) component that acts as the gamma-tubulin complex-binding protein of the SPB outer plaque (PubMed:9670012). Anchors cytoplasmic microtubules at the half bridge of the spindle pole body (SPB) and accordingly functions in nuclear position and spindle orientation, including anaphase spindle migration into the bud (PubMed:10428957, PubMed:9718373). Recruits KIN4 kinase to both SPBs when cytoplasmic microtubules are defective, to delay mitotic exit (PubMed:17967947). Links cytoplasmic microtubules with spindle orientation checkpoint (SPOC) components and, therefore, could function as part of the sensors of spindle orientation defects (PubMed:17967947, PubMed:9606209). Required for cytoplasmic astral microtubule growth during mitosis (PubMed:9606209, PubMed:9670012). Is strictly required for mating and karyogamy (PubMed:10428957)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPG9;E9P941", "ec_number_list": "", "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0051010 microtubule plus-end binding;GO:0099609 microtubule lateral binding", "go_cellular_component": "GO:0005876 spindle microtubule;GO:0005816 spindle pole body;GO:1905721 mitotic spindle astral microtubule end;GO:0061499 outer plaque of mitotic spindle pole body;GO:0005824 outer plaque of spindle pole body", "go_biological_process": "GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0031122 cytoplasmic microtubule organization;GO:0030953 astral microtubule organization;GO:0110121 gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P39723-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39726-1", "uniprot_id": "GCSH_YEAST", "mass": 18793.0, "length": 170, "protein_name": "Glycine cleavage system H protein, mitochondrial", "gene_name": "GCV3", "organism": "Yeast", "refseq_name": "glycine decarboxylase subunit H", "refseq_ac": "NP_009355", "gene_names_uniprotkb": "GCV3; FUN40", "gene_names_refseq": "GCV3", "protein_names_uniprotkb": "Glycine cleavage system H protein, mitochondrial; Glycine decarboxylase complex subunit H", "protein_names_refseq": "glycine decarboxylase subunit H", "tax_id": 559292, "disease": "multiple mitochondrial dysfunctions syndrome (Disease Ontology:DOID:0070330); amino acid metabolic disorder (Disease Ontology:DOID:9252); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (sce:YAL044C); (R-SCE-6783984); (R-SCE-9857492)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12748633;14562095;14562106;14576278;18407956;24374639;33491328;7731988;9020168", "class_list": "", "function": "The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPH2", "ec_number_list": "", "go_molecular_function": "GO:0031405 lipoic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:0009249 protein lipoylation;GO:0019464 glycine decarboxylation via glycine cleavage system;GO:0006546 glycine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P39726-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39727-1", "uniprot_id": "ERV46_YEAST", "mass": 46235.0, "length": 415, "protein_name": "ER-derived vesicles protein ERV46", "gene_name": "ERV46", "organism": "Yeast", "refseq_name": "retrograde cargo receptor ERV46", "refseq_ac": "NP_009358", "gene_names_uniprotkb": "ERV46; FUN9", "gene_names_refseq": "ERV46; FUN9", "protein_names_uniprotkb": "ER-derived vesicles protein ERV46", "protein_names_refseq": "retrograde cargo receptor ERV46", "tax_id": 559292, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (sce:YAL042W)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11157978;11758914;12426381;16107716;24374639;33491328;7731988", "class_list": "", "function": "Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. The C-terminal Phe-Tyr motif is required for exit from the endoplasmic reticulum. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPH4", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P39727-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39729-1", "uniprot_id": "RBG1_YEAST", "mass": 40701.0, "length": 369, "protein_name": "Ribosome-interacting GTPase 1", "gene_name": "RBG1", "organism": "Yeast", "refseq_name": "GTP-binding protein RBG1", "refseq_ac": "NP_009364", "gene_names_uniprotkb": "RBG1; FUN11", "gene_names_refseq": "FUN11; RBG1", "protein_names_uniprotkb": "Ribosome-interacting GTPase 1; GTP-binding protein RBG1; Genetically interacts with ribosomal genes protein 1", "protein_names_refseq": "GTP-binding protein RBG1", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL036C)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;16702403;17322287;19448108;22814378;24374639;33481703;7731988", "class_list": "", "function": "Involved in ribosomal function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPI1", "ec_number_list": "", "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:1903833 positive regulation of cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P39729-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39731-1", "uniprot_id": "MTW1_YEAST", "mass": 33243.0, "length": 289, "protein_name": "Kinetochore-associated protein MTW1", "gene_name": "MTW1", "organism": "Yeast", "refseq_name": "MIND complex subunit MTW1", "refseq_ac": "NP_009367", "gene_names_uniprotkb": "MTW1; DSN3; NSL2; YAL034AW", "gene_names_refseq": "DSN3; MTW1; NSL2", "protein_names_uniprotkb": "Kinetochore-associated protein MTW1; Mis12-like protein", "protein_names_refseq": "MIND complex subunit MTW1", "tax_id": 559292, "disease": "", "pathway": " (sce:YAL034W-A)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10398680;12455957;14562106;14602074;14633972;14657030;14690591;24374639;36269765;7731988", "class_list": "", "function": "Acts as an essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VPI3", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000940 outer kinetochore;GO:0000444 MIS12/MIND type complex", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P39731-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39923-1", "uniprot_id": "NPR2_YEAST", "mass": 69859.0, "length": 615, "protein_name": "Nitrogen permease regulator 2", "gene_name": "NPR2", "organism": "Yeast", "refseq_name": "nitrogen permease regulating protein NPR2", "refseq_ac": "NP_010852", "gene_names_uniprotkb": "NPR2", "gene_names_refseq": "NPR2", "protein_names_uniprotkb": "Nitrogen permease regulator 2", "protein_names_refseq": "nitrogen permease regulating protein NPR2", "tax_id": 559292, "disease": "familial focal epilepsy with variable foci 2 (Disease Ontology:DOID:0081422); cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YEL062W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "12748633;12869630;14562106;17322287;18407956;19521502;19779198;20489023;21126336;21177495;21454883;23749301;24374639;26510498;32597660;33229814;33481703;33491328;7867803;9169868", "class_list": "", "function": "Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis (PubMed:21454883). Mediates inactivation of the TORC1 complex in response to amino acid starvation (PubMed:19521502, PubMed:26510498). Post-transcriptional regulator of nitrogen permeases (PubMed:19521502). May be involved in putative NPR1-dependent phosphorylation of nitrogen permeases or in the processing and targeting of nitrogen permeases at the level of the endoplasmic reticulum (PubMed:19521502)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "D3DLI8;Q6B264", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005774 vacuolar membrane;GO:1990130 GATOR1 complex;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:0015824 proline transport;GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:0010508 positive regulation of autophagy;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P39923-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39925-1", "uniprot_id": "AFG3_YEAST", "mass": 84544.0, "length": 761, "protein_name": "Mitochondrial inner membrane m-AAA protease component YTA10", "gene_name": "AFG3", "organism": "Yeast", "refseq_name": "AAA family ATPase AFG3", "refseq_ac": "NP_010933", "gene_names_uniprotkb": "AFG3; YTA10", "gene_names_refseq": "AFG3; YTA10", "protein_names_uniprotkb": "Mitochondrial inner membrane m-AAA protease component YTA10; 3.4.24.-; 3.6.-.-; ATPase family gene 3 protein; Tat-binding homolog 10", "protein_names_refseq": "AAA family ATPase AFG3", "tax_id": 559292, "disease": "spastic ataxia 5 (Disease Ontology:DOID:0050944); spastic ataxia (Disease Ontology:DOID:0050952); spinocerebellar ataxia 28 (Disease Ontology:DOID:0050977); optic atrophy 12 (Disease Ontology:DOID:0080840); neurodegenerative disease (Disease Ontology:DOID:1289); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (sce:YER017C); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10207067;12417197;14562106;16239145;17245427;19748354;21610694;23283966;24374639;29030426;33491328;7754704;7900428;8681382;9169868;9707443", "class_list": "", "function": "Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins (PubMed:19748354, PubMed:8681382). YTA10/AFG3 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (PubMed:19748354). The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes (PubMed:9707443). The m-AAA protease carries out protein quality control in the inner membrane of the mitochondria by mediating degradation of mistranslated or misfolded polypeptides (PubMed:8681382). It also mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (PubMed:16239145, PubMed:21610694). Promotes maturation of cytochrome c peroxidase (CCP1) by acting as a membrane protein dislocase via its ATPase activity: pulls the CCP1 transmembrane to the matrix prior to processing by the rhomboid protease PCP1 (PubMed:12417197, PubMed:17245427). The membrane protein dislocase activity is also required to dislocate moderately hydrophobic transmembrane segments from the membrane (PubMed:23283966, PubMed:29030426)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLR5", "ec_number_list": "7.1.1.9;3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005745 m-AAA complex;GO:0097002 mitochondrial inner boundary membrane", "go_biological_process": "GO:0030163 protein catabolic process;GO:0034982 mitochondrial protein processing;GO:0051604 protein maturation;GO:0030150 protein import into mitochondrial matrix;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P39925-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39926-1", "uniprot_id": "SSO2_YEAST", "mass": 33734.0, "length": 295, "protein_name": "Protein SSO2", "gene_name": "SSO2", "organism": "Yeast", "refseq_name": "syntaxin", "refseq_ac": "NP_013908", "gene_names_uniprotkb": "SSO2; YM8010.13C", "gene_names_refseq": "SSO2", "protein_names_uniprotkb": "Protein SSO2", "protein_names_refseq": "syntaxin", "tax_id": 559292, "disease": "familial hemophagocytic lymphohistiocytosis 4 (Disease Ontology:DOID:0110924); Hirschsprung's disease (Disease Ontology:DOID:10487); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); disease of mental health (Disease Ontology:DOID:150); epilepsy (Disease Ontology:DOID:1826); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YMR183C); (R-SCE-114516); (R-SCE-199992); (R-SCE-204005); (R-SCE-9609523)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "14562106;18407956;20948969;24374639;33481703;8223426;9169872", "class_list": "", "function": "Required for vesicle fusion with the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W007", "ec_number_list": "", "go_molecular_function": "GO:0000149 SNARE binding;GO:0070300 phosphatidic acid binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P39926-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39928-1", "uniprot_id": "SLN1_YEAST", "mass": 134435.0, "length": 1220, "protein_name": "Osmosensing histidine protein kinase SLN1", "gene_name": "SLN1", "organism": "Yeast", "refseq_name": "histidine kinase", "refseq_ac": "NP_012119", "gene_names_uniprotkb": "SLN1; YPD2", "gene_names_refseq": "SLN1; YPD2", "protein_names_uniprotkb": "Osmosensing histidine protein kinase SLN1; 2.7.13.3; Osmolarity two-component system protein SLN1; Tyrosine phosphatase-dependent protein 2", "protein_names_refseq": "histidine kinase", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL147C)", "pathway_count": 1, "publication_count": 26, "publication_id_list": "14562106;14656441;14665464;15590828;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20489023;20702584;21177495;22218487;23749301;24374639;25734609;32597660;33481703;33491328;8183345;8211183;8808622;9169870;9843501", "class_list": "", "function": "Histidine kinase that acts as an osmosensor at the plasma membrane. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to changes in the osmolarity of the extracellular environment. Under normal osmotic conditions, the histidine kinase autophosphorylates His-576. This phosphate is subsequently transferred to Asp-1144, from where it is relayed to 'His-64' of the phosphorelay intermediate protein YPD1. Under high osmolarity conditions, the histidine kinase is no longer active., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "D6VVE0", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0000155 phosphorelay sensor kinase activity;GO:0004673 protein histidine kinase activity;GO:0005034 osmosensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0000160 phosphorelay signal transduction system;GO:0007234 osmosensory signaling via phosphorelay pathway", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P39928-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39943-1", "uniprot_id": "MIG3_YEAST", "mass": 43119.0, "length": 394, "protein_name": "Transcription corepressor MIG3", "gene_name": "MIG3", "organism": "Yeast", "refseq_name": "Mig3p", "refseq_ac": "NP_010945", "gene_names_uniprotkb": "MIG3", "gene_names_refseq": "MIG3", "protein_names_uniprotkb": "Transcription corepressor MIG3; Multicopy inhibitor of growth protein 3", "protein_names_refseq": "Mig3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER028C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12161108;14562095;14993292;24374639;33481703;33491328;9169868", "class_list": "", "function": "DNA-binding transcriptional repressor involved in response to toxic agents such as ribonucleotide reductase inhibitor, hydroxyurea (HU)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLS7", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045471 response to ethanol;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P39943-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39946-1", "uniprot_id": "LIS1_YEAST", "mass": 56901.0, "length": 494, "protein_name": "Nuclear distribution protein PAC1", "gene_name": "PAC1", "organism": "Yeast", "refseq_name": "Pac1p", "refseq_ac": "NP_014912", "gene_names_uniprotkb": "PAC1; LIS1", "gene_names_refseq": "LIS1; PAC1", "protein_names_uniprotkb": "Nuclear distribution protein PAC1; LIS-1; Lissencephaly-1 homolog; nudF homolog", "protein_names_refseq": "Pac1p", "tax_id": 559292, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); lissencephaly 1 (Disease Ontology:DOID:0112237); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (sce:YOR269W); (R-SCE-983168)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12566428;15965467;19185494;24374639;8896271;9153759;9169874;9201714", "class_list": "", "function": "Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. Following plus end binding, dynein may be offloaded to the cortex by NUM1. Required for viability in the absence of the kinesin-related microtubule-dependent motor protein CIN8., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2W9", "ec_number_list": "", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0051301 cell division;GO:0000132 establishment of mitotic spindle orientation;GO:0047496 vesicle transport along microtubule;GO:0031023 microtubule organizing center organization;GO:0007097 nuclear migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P39946-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39952-1", "uniprot_id": "OXA1_YEAST", "mass": 44816.0, "length": 402, "protein_name": "Mitochondrial inner membrane protein OXA1", "gene_name": "OXA1", "organism": "Yeast", "refseq_name": "membrane insertase OXA1", "refseq_ac": "NP_011081", "gene_names_uniprotkb": "OXA1; PET1402", "gene_names_refseq": "OXA1", "protein_names_uniprotkb": "Mitochondrial inner membrane protein OXA1; Cytochrome oxidase biogenesis protein OXA1; Oxidase assembly protein 1", "protein_names_refseq": "membrane insertase OXA1", "tax_id": 559292, "disease": "", "pathway": " (sce:YER154W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12191770;14562106;14657017;17322287;20025673;22513091;22829595;22846909;22904327;24374639;25609543;7816036;8196054;9169868;9171337;9482871", "class_list": "", "function": "Mitochondrial inner membrane insertase that mediates the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the inner membrane. Links mitoribosomes with the inner membrane (PubMed:22904327). Forms pores capable of accommodating translocating protein segments (PubMed:22829595). Essential for the activity and assembly of cytochrome c oxidase (PubMed:22904327). Plays a central role in the translocation and export of the N-terminal part of the COX2 protein into the mitochondrial intermembrane space., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM61", "ec_number_list": "", "go_molecular_function": "GO:0097177 mitochondrial ribosome binding;GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0030061 mitochondrial crista;GO:0097002 mitochondrial inner boundary membrane", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P39952-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39956-1", "uniprot_id": "RPH1_YEAST", "mass": 90211.0, "length": 796, "protein_name": "DNA damage-responsive transcriptional repressor RPH1", "gene_name": "RPH1", "organism": "Yeast", "refseq_name": "Rph1p", "refseq_ac": "NP_011096", "gene_names_uniprotkb": "RPH1", "gene_names_refseq": "KDM4; RPH1", "protein_names_uniprotkb": "DNA damage-responsive transcriptional repressor RPH1", "protein_names_refseq": "Rph1p", "tax_id": 559292, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); withdrawal disorder (Disease Ontology:DOID:0060001); autosomal dominant intellectual developmental disorder 65 (Disease Ontology:DOID:0061038); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); head and neck cancer (Disease Ontology:DOID:11934); autistic disorder (Disease Ontology:DOID:12849); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); colorectal cancer (Disease Ontology:DOID:9256); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (sce:YER169W)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10523651;11809875;14562095;14562106;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20190278;20702584;21126336;21177495;21296759;23749301;24374639;25660547;30516470;32597660;32619236;33334889;33481703;33491328;33502312;34965436;35183557;9169868;9171100", "class_list": "", "function": "Transcriptional repressor of photolyase PHR1. Recognizes and binds the sequence AG(4) in the upstream repressing sequence of PHR1. Derepresses PHR1 transcription when phosphorylated., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 35, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM77", "ec_number_list": "", "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0032454 histone H3K9 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0010507 negative regulation of autophagy;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P39956-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39962-1", "uniprot_id": "KC13_YEAST", "mass": 60261.0, "length": 524, "protein_name": "Casein kinase I homolog 3", "gene_name": "YCK3", "organism": "Yeast", "refseq_name": "casein kinase YCK3", "refseq_ac": "NP_011049", "gene_names_uniprotkb": "YCK3; CKI3", "gene_names_refseq": "CKI3; YCK3", "protein_names_uniprotkb": "Casein kinase I homolog 3; 2.7.11.1", "protein_names_refseq": "casein kinase YCK3", "tax_id": 559292, "disease": "", "pathway": " (sce:YER123W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562106;14668479;17287358;18407956;19684113;19779198;19795423;19823750;20489023;21177495;23749301;24374639;30516470;32391792;32597660;33229814;33481703;33491328;8816449;9169868", "class_list": "", "function": "Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates MON1, inhibiting the guanine nucleotide exchange factor activity of the MON1-CCZ1 complex, possibly by preventing its recruitment to membranes by small GTPase RAB5 homologs (PubMed:32391792)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D3DM29", "ec_number_list": "2.7.11.22;2.7.11.11;2.7.11.1;2.7.12.2;2.7.12.1;2.7.11.24;2.7.11.17;2.7.11.23;2.7.11.25;2.7.11.13;3.1.26.-;2.7.11.21;2.7.1.67;3.6.-.-;3.6.1.-", "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P39962-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39966-1", "uniprot_id": "PP2C2_YEAST", "mass": 50388.0, "length": 464, "protein_name": "Protein phosphatase 2C homolog 2", "gene_name": "PTC2", "organism": "Yeast", "refseq_name": "type 2C protein phosphatase PTC2", "refseq_ac": "NP_011013", "gene_names_uniprotkb": "PTC2", "gene_names_refseq": "PTC2", "protein_names_uniprotkb": "Protein phosphatase 2C homolog 2; 3.1.3.16; PP2C-2", "protein_names_refseq": "type 2C protein phosphatase PTC2", "tax_id": 559292, "disease": "", "pathway": " (sce:YER089C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10580002;12477803;12667463;14562106;15665377;17325030;18407956;19779198;20489023;20702584;23749301;24374639;30655342;33481703;33491328;9169868;9528768", "class_list": "", "function": "Dephosphorylating regulator for many key proteins (PubMed:10580002, PubMed:12477803, PubMed:12667463, PubMed:9528768). Dephosphorylates the cell cycle master regulator CDC28/cyclin-dependent kinase 1; its activity appears redundant with phosphatase PTC3 (PubMed:10580002). Dephosphorylates HOG1 at 'Thr-171', to attenuate activation of the stress-activated p38MAPK cascade; its activity appears redundant with phosphatase PTC3 (PubMed:12477803). Positively regulates both nonselective macroautophagy as well as the selective cytoplasm-to-vacuole (cvt) autophagy pathway and the genotoxin-induced targeted autophagy (GTA) pathway, possibly by dephosphorylating ATG13 to enable the interaction between the ATG17-ATG29-ATG31 and ATG1-ATG13 complexes; its activity appears redundant with phosphatase PTC3 (PubMed:30655342). Dephosphorylates RAD53, to regulate DNA damage checkpoint signaling (PubMed:12667463). Dephosphorylates IRE1, to negatively regulate the endoplasmic reticulum unfolded protein response (PubMed:9528768)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLZ6", "ec_number_list": "3.1.3.16;3.1.3.43;3.1.3.48", "go_molecular_function": "GO:1990439 MAP kinase serine/threonine phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response;GO:0007165 signal transduction;GO:0010508 positive regulation of autophagy;GO:1903753 negative regulation of p38MAPK cascade;GO:1904289 regulation of mitotic DNA damage checkpoint", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P39966-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39970-1", "uniprot_id": "ACA1_YEAST", "mass": 54592.0, "length": 489, "protein_name": "ATF/CREB activator 1", "gene_name": "ACA1", "organism": "Yeast", "refseq_name": "Aca1p", "refseq_ac": "NP_010964", "gene_names_uniprotkb": "ACA1", "gene_names_refseq": "ACA1", "protein_names_uniprotkb": "ATF/CREB activator 1", "protein_names_refseq": "Aca1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER045C); (R-SCE-3214847); (R-SCE-450341)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10825197;12051917;14966276;16464826;17252314;18407956;21177495;24374639;33491328;9169868", "class_list": "", "function": "Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources. Regulates the expression of COS8. Has efficient silencing blocking activities., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLU6", "ec_number_list": "", "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P39970-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39979-1", "uniprot_id": "HPA3_YEAST", "mass": 18814.0, "length": 161, "protein_name": "D-amino-acid N-acetyltransferase HPA3", "gene_name": "HPA3", "organism": "Yeast", "refseq_name": "D-amino-acid N-acetyltransferase", "refseq_ac": "NP_010848", "gene_names_uniprotkb": "HPA3", "gene_names_refseq": "HPA3", "protein_names_uniprotkb": "D-amino-acid N-acetyltransferase HPA3; 2.3.1.36; DNT", "protein_names_refseq": "D-amino-acid N-acetyltransferase", "tax_id": 559292, "disease": "anxiety disorder (Disease Ontology:DOID:2030); mood disorder (Disease Ontology:DOID:3324)", "pathway": " (sce:YEL066W); (R-SCE-351200)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10600387;14562095;14562106;15375647;16362288;22814378;23775086;24374639;31478186;9169868", "class_list": "", "function": "N-acetyltransferase that acts on a wide range of D-amino acids (PubMed:15375647). Catalyzes the N-acetylation through an ordered bi-bi mechanism, in which acetyl-CoA is the first substrate to be bound and CoA is the last product to be liberated (PubMed:15375647). D-amino acids are toxic for the cell and their N-acetylation, preceding removal from cells, plays an important role in detoxification of D-amino acids (PubMed:10600387, PubMed:16362288, PubMed:31478186). In vitro, capable of acetylating histone H4 at 'Lys-8' and polyamines like putrescine, spermidine and spermine (PubMed:23775086)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLI4", "ec_number_list": "2.3.1.36;2.3.1.48", "go_molecular_function": "GO:0008080 N-acetyltransferase activity;GO:0047812 D-amino-acid N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006473 protein acetylation;GO:0046416 D-amino acid metabolic process;GO:0070458 cellular detoxification of nitrogen compound", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P39979-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39984-1", "uniprot_id": "HAT2_YEAST", "mass": 45060.0, "length": 401, "protein_name": "Histone acetyltransferase type B subunit 2", "gene_name": "HAT2", "organism": "Yeast", "refseq_name": "Hat2p", "refseq_ac": "NP_010858", "gene_names_uniprotkb": "HAT2", "gene_names_refseq": "HAT2", "protein_names_uniprotkb": "Histone acetyltransferase type B subunit 2", "protein_names_refseq": "Hat2p", "tax_id": 559292, "disease": "X-linked spermatogenic failure 9 (Disease Ontology:DOID:0061177); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (sce:YEL056W); (R-SCE-3214815); (R-SCE-3214847)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10075411;10982821;14761951;15099519;16023114;24374639;24835250;33491328;8858151;9169868;9575221", "class_list": "", "function": "Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. HAT2 is required for high affinity binding of the acetyltransferase to histone H4, for the nuclear location of HAT1 and for the HAT1-HIF1 interaction. Alone, it is unable to bind to H4, requiring HAT1 for high affinity interaction with the histone tail. HAT2 also has a HAT1 independent function in life-span regulation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLJ4", "ec_number_list": "", "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000123 histone acetyltransferase complex;GO:0000781 chromosome, telomeric region;GO:0070210 Rpd3L-Expanded complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P39984-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39985-1", "uniprot_id": "DPO5_YEAST", "mass": 115894.0, "length": 1022, "protein_name": "rRNA processing protein POL5", "gene_name": "POL5", "organism": "Yeast", "refseq_name": "DNA-directed DNA polymerase", "refseq_ac": "NP_010859", "gene_names_uniprotkb": "POL5", "gene_names_refseq": "POL5", "protein_names_uniprotkb": "rRNA processing protein POL5; rDNA transcriptional regulator POL5", "protein_names_refseq": "DNA-directed DNA polymerase", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL055C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12093911;12695662;14562095;14562106;18407956;19779198;19795423;19823750;20489023;24374639;31413149;31745560;33481703;33491328;7667891;9169868", "class_list": "", "function": "Participates in rRNA processing and the biogenesis of both the large and small ribosomal subunits (PubMed:31413149, PubMed:31745560). In the biogenesis of the small ribosomal subunit, plays a role in the release of 5' ETS (external transcribed sequence) fragments from early pre-40S particles, and promotes the recycling of associated small subunit assembly factors (PubMed:31745560). In the biogenesis of the large subunit, associates with the 25S rRNA sequence and facilitates the association of ribosomal proteins that form the outer face of the peptide exit tunnel (PubMed:31745560). Binds sequences within the 35S pre-rRNA, including domain III of the 25S rRNA domain, the 5' ETS, and ITS2 (internal transcribed sequence 2), as well as the large ribosomal subunit pre-rRNA 27SB (PubMed:31413149, PubMed:31745560). Required for proper transcription of rRNA, possibly via recycling of small subunit assembly factors that have a putative role in rDNA transcription (PubMed:12093911, PubMed:31745560)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLJ5;Q9Y737", "ec_number_list": "", "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0000166 nucleotide binding;GO:0000182 rDNA binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0009303 rRNA transcription;GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly;GO:0090070 positive regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P39985-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39993-1", "uniprot_id": "GEA2_YEAST", "mass": 165668.0, "length": 1459, "protein_name": "ARF guanine-nucleotide exchange factor 2", "gene_name": "GEA2", "organism": "Yeast", "refseq_name": "Arf family guanine nucleotide exchange factor GEA2", "refseq_ac": "NP_010892", "gene_names_uniprotkb": "GEA2", "gene_names_refseq": "GEA2", "protein_names_uniprotkb": "ARF guanine-nucleotide exchange factor 2", "protein_names_refseq": "Arf family guanine nucleotide exchange factor GEA2", "tax_id": 559292, "disease": "Charcot-Marie-Tooth disease dominant intermediate A (Disease Ontology:DOID:0110202)", "pathway": " (sce:YEL022W); (R-SCE-199992); (R-SCE-5620916); (R-SCE-6807878); (R-SCE-6811434); (R-SCE-6811438)", "pathway_count": 6, "publication_count": 21, "publication_id_list": "11888276;12808035;14562106;14734650;15665377;17330950;17563356;18407956;19779198;19898464;22218487;23749301;24374639;25190516;30516470;32597660;33229814;33481703;33491328;8945477;9169868", "class_list": "", "function": "Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in maintaining mitochondrial morphology (PubMed:25190516). Stimulates DRS2 flippase activity (PubMed:19898464)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DLM6", "ec_number_list": "", "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0016236 macroautophagy;GO:0030036 actin cytoskeleton organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0033363 secretory granule organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P39993-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39995-1", "uniprot_id": "EAF5_YEAST", "mass": 31644.0, "length": 279, "protein_name": "Chromatin modification-related protein EAF5", "gene_name": "EAF5", "organism": "Yeast", "refseq_name": "Eaf5p", "refseq_ac": "NP_010897", "gene_names_uniprotkb": "EAF5", "gene_names_refseq": "EAF5", "protein_names_uniprotkb": "Chromatin modification-related protein EAF5; ESA1-associated factor 5", "protein_names_refseq": "Eaf5p", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL018W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;14562106;14690591;15353583;15485911;24374639;33491328;9169868", "class_list": "", "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLN1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0035267 NuA4 histone acetyltransferase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006335 DNA replication-dependent chromatin assembly;GO:0006337 nucleosome disassembly;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P39995-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39997-1", "uniprot_id": "NPP2_YEAST", "mass": 57355.0, "length": 493, "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase 2", "gene_name": "NPP2", "organism": "Yeast", "refseq_name": "nucleotide diphosphatase/phosphodiesterase NPP2", "refseq_ac": "NP_010900", "gene_names_uniprotkb": "NPP2", "gene_names_refseq": "NPP2", "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase 2; E-NPP 2; Nucleotide diphosphatase", "protein_names_refseq": "nucleotide diphosphatase/phosphodiesterase NPP2", "tax_id": 559292, "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); stroke (Disease Ontology:DOID:0051061); ossification of the posterior longitudinal ligament of spine (Disease Ontology:DOID:0060887); aortic valve disease 1 (Disease Ontology:DOID:0080333); otitis media (Disease Ontology:DOID:10754); spondyloarthropathy (Disease Ontology:DOID:1123); tympanosclerosis (Disease Ontology:DOID:1214); cardiovascular system disease (Disease Ontology:DOID:1287); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); glioblastoma (Disease Ontology:DOID:3068); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YEL016C); (R-SCE-196843); (R-SCE-6798695); (R-SCE-6814848); (R-SCE-9840310)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "16278456;17322287;24374639;33491328;33502312;9169868", "class_list": "", "function": "Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and PHO5., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D3DLN4;Q6B2P3", "ec_number_list": "3.1.4.1;3.6.1.9", "go_molecular_function": "GO:0004528 phosphodiesterase I activity;GO:0047429 nucleoside triphosphate diphosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0009141 nucleoside triphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P39997-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P39998-1", "uniprot_id": "EDC3_YEAST", "mass": 61340.0, "length": 551, "protein_name": "Enhancer of mRNA-decapping protein 3", "gene_name": "EDC3", "organism": "Yeast", "refseq_name": "Edc3p", "refseq_ac": "NP_010901", "gene_names_uniprotkb": "EDC3; LSM16", "gene_names_refseq": "DCP3; EDC3; LSM16", "protein_names_uniprotkb": "Enhancer of mRNA-decapping protein 3", "protein_names_refseq": "Edc3p", "tax_id": 559292, "disease": "autosomal recessive intellectual developmental disorder 50 (Disease Ontology:DOID:0081213)", "pathway": " (sce:YEL015W); (R-SCE-430039)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "14562106;15020463;17287358;17330950;18407956;18678652;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;30516470;32597660;33229814;33481703;33491328;9169868", "class_list": "", "function": "Stimulates decapping of both stable and unstable mRNA during mRNA decay. Does not affect nonsense-mediated mRNA decay. Required for normal P-body assembly., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DLN5", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0033962 P-body assembly;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P39998-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40003-1", "uniprot_id": "VAB2_YEAST", "mass": 31365.0, "length": 282, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit VAB2", "gene_name": "VAB2", "organism": "Yeast", "refseq_name": "Vab2p", "refseq_ac": "NP_010911", "gene_names_uniprotkb": "VAB2; VAB31", "gene_names_refseq": "VAB2; VAB31", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit VAB2; BLOC-1 subunit VAB2; VAC8-binding protein 2", "protein_names_refseq": "Vab2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL005C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10888680;14562095;21159114;23749301;24374639;33491328;9169868", "class_list": "", "function": "Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLP2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005773 vacuole;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40003-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40009-1", "uniprot_id": "YND1_YEAST", "mass": 71852.0, "length": 630, "protein_name": "Golgi apyrase", "gene_name": "YND1", "organism": "Yeast", "refseq_name": "apyrase", "refseq_ac": "NP_010920", "gene_names_uniprotkb": "YND1", "gene_names_refseq": "APY1; YEJ5; YND1", "protein_names_uniprotkb": "Golgi apyrase; 3.6.1.5; ADPase; ATP-diphosphatase; ATP-diphosphohydrolase; Adenosine diphosphatase; Golgi nucleoside diphosphatase; Yeast nucleoside diphosphatase 1", "protein_names_refseq": "apyrase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER005W); (R-SCE-8850843)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10409709;10954728;14562095;14562106;16227198;16702413;17322287;18407956;19779198;20702584;21126336;22814378;23749301;24374639;30516470;33481703;33491328;9169868", "class_list": "", "function": "Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLQ1;Q6B252", "ec_number_list": "3.6.1.5", "go_molecular_function": "GO:0005524 ATP binding;GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0017110 nucleoside diphosphate phosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006256 UDP catabolic process;GO:0006665 sphingolipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0046036 CTP metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P40009-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40011-1", "uniprot_id": "RRAAH_YEAST", "mass": 25563.0, "length": 234, "protein_name": "4-hydroxy-4-methyl-2-oxoglutarate aldolase", "gene_name": "", "organism": "Yeast", "refseq_name": "bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase", "refseq_ac": "NP_010926", "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "4-hydroxy-4-methyl-2-oxoglutarate aldolase; 4.1.1.112; 4.1.3.17; HMG aldolase; OAA decarboxylase; Oxaloacetate decarboxylase; Regulator of ribonuclease activity homolog; RraA-like protein", "protein_names_refseq": "bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER010C)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;16195557;22814378;24359411;24374639;9169868", "class_list": "", "function": "Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLQ7", "ec_number_list": "1.1.1.38;4.1.1.112;4.1.3.17", "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0046872 metal ion binding;GO:0047443 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity", "go_cellular_component": "", "go_biological_process": "GO:0019619 3,4-dihydroxybenzoate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40011-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40013-1", "uniprot_id": "BIM1_YEAST", "mass": 38362.0, "length": 344, "protein_name": "Protein BIM1", "gene_name": "BIM1", "organism": "Yeast", "refseq_name": "microtubule-binding protein BIM1", "refseq_ac": "NP_010932", "gene_names_uniprotkb": "BIM1", "gene_names_refseq": "BIM1; YEB1", "protein_names_uniprotkb": "Protein BIM1", "protein_names_refseq": "microtubule-binding protein BIM1", "tax_id": 559292, "disease": "congenital symmetric circumferential skin creases 2 (Disease Ontology:DOID:0112243)", "pathway": " (sce:YER016W)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "14562106;17287358;17330950;17563356;18407956;19667128;19779198;19795423;19823750;20702584;21126336;21177495;22814378;23749301;24374639;32597660;33481703;33491328;9169868;9398684", "class_list": "", "function": "Binds microtubules., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLR4", "ec_number_list": "", "go_molecular_function": "GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0051233 spindle midzone;GO:0005815 microtubule organizing center;GO:0005881 cytoplasmic microtubule;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0007026 negative regulation of microtubule depolymerization;GO:0031116 positive regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40013-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40015-1", "uniprot_id": "ISC1_YEAST", "mass": 53940.0, "length": 477, "protein_name": "Inositol phosphosphingolipids phospholipase C", "gene_name": "ISC1", "organism": "Yeast", "refseq_name": "inositol phosphosphingolipid phospholipase", "refseq_ac": "NP_010935", "gene_names_uniprotkb": "ISC1", "gene_names_refseq": "ISC1", "protein_names_uniprotkb": "Inositol phosphosphingolipids phospholipase C; 3.1.4.-; IPS phospholipase C; IPS-PLC; N-SMase; Neutral sphingomyelinase; nSMase", "protein_names_refseq": "inositol phosphosphingolipid phospholipase", "tax_id": 559292, "disease": "", "pathway": " (sce:YER019W); (R-SCE-9840310)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11006294;14562106;14699160;16847258;17880915;24374639;27821475;33491328;9169868", "class_list": "", "function": "Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C) (PubMed:11006294). Regulates sphingolipid metabolism in mitochondria, especially the formation of alpha-hydroxylated very long chain phytoceramides. The generated ceramides contribute to the normal function of mitochondria (PubMed:17880915). Also active on sphingomyelin (SM), but this activity is probably not physiologically relevant (PubMed:11006294)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLR7", "ec_number_list": "3.1.4.-", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0004767 sphingomyelin phosphodiesterase activity;GO:0052712 inositol phosphosphingolipid phospholipase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0046513 ceramide biosynthetic process;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint;GO:0072711 cellular response to hydroxyurea", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P40015-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40016-1", "uniprot_id": "RPN3_YEAST", "mass": 60393.0, "length": 523, "protein_name": "26S proteasome regulatory subunit RPN3", "gene_name": "RPN3", "organism": "Yeast", "refseq_name": "proteasome regulatory particle lid subunit RPN3", "refseq_ac": "NP_010938", "gene_names_uniprotkb": "RPN3; SUN2", "gene_names_refseq": "RPN3; SUN2", "protein_names_uniprotkb": "26S proteasome regulatory subunit RPN3", "protein_names_refseq": "proteasome regulatory particle lid subunit RPN3", "tax_id": 559292, "disease": "", "pathway": " (sce:YER021W); (R-SCE-1236978); (R-SCE-5668541); (R-SCE-5689880); (R-SCE-6798695); (R-SCE-9907900)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "12504901;14562106;18407956;19795423;19823750;20486117;22927375;24374639;33491328;8668124;9017604;9169868", "class_list": "", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLS0", "ec_number_list": "", "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P40016-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40018-1", "uniprot_id": "RSMB_YEAST", "mass": 22379.0, "length": 196, "protein_name": "Small nuclear ribonucleoprotein-associated protein B", "gene_name": "SMB1", "organism": "Yeast", "refseq_name": "mRNA splicing protein SMB1", "refseq_ac": "NP_010946", "gene_names_uniprotkb": "SMB1", "gene_names_refseq": "SMB1", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein B; Sm protein B; Sm-B; SmB; snRNP-B", "protein_names_refseq": "mRNA splicing protein SMB1", "tax_id": 559292, "disease": "cerebrocostomandibular syndrome (Disease Ontology:DOID:0111248); Prader-Willi syndrome (Disease Ontology:DOID:11983); Angelman syndrome (Disease Ontology:DOID:1932); mixed connective tissue disease (Disease Ontology:DOID:3492); lung adenocarcinoma (Disease Ontology:DOID:3910); tauopathy (Disease Ontology:DOID:680)", "pathway": " (sce:YER029C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10369684;10449419;11027265;11302706;11804584;11884590;11983179;14562106;14690591;17322287;22814378;24374639;33229814;33491328;9169868;9528767;9630245", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DLS8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0070990 snRNP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P40018-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40021-1", "uniprot_id": "ZRG8_YEAST", "mass": 119350.0, "length": 1076, "protein_name": "Zinc-regulated protein 8", "gene_name": "ZRG8", "organism": "Yeast", "refseq_name": "Zrg8p", "refseq_ac": "NP_010950", "gene_names_uniprotkb": "ZRG8", "gene_names_refseq": "ZRG8", "protein_names_uniprotkb": "Zinc-regulated protein 8", "protein_names_refseq": "Zrg8p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER033C)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10978274;14562095;15665377;15972461;17043893;17287358;17330950;17563356;18407956;19684113;19779198;19795423;19823750;21126336;21177495;22218487;23749301;24374639;24909858;32597660;33481703;33491328;9169868", "class_list": "", "function": "Involved in the integrity functions of RAM, a conserved signaling network that regulates maintenance of polarized growth and daughter-cell-specific transcription., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 49, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLT2", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005933 cellular bud;GO:0005934 cellular bud tip;GO:0005935 cellular bud neck", "go_biological_process": "GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P40021-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40024-1", "uniprot_id": "ARB1_YEAST", "mass": 68377.0, "length": 610, "protein_name": "ABC transporter ATP-binding protein ARB1", "gene_name": "ARB1", "organism": "Yeast", "refseq_name": "ATP-binding cassette family ATPase ARB1", "refseq_ac": "NP_010953", "gene_names_uniprotkb": "ARB1", "gene_names_refseq": "ARB1", "protein_names_uniprotkb": "ABC transporter ATP-binding protein ARB1; 3.6.5.-; ATP-binding cassette protein involved in ribosome biogenesis 1", "protein_names_refseq": "ATP-binding cassette family ATPase ARB1", "tax_id": 559292, "disease": "", "pathway": " (sce:YER036C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "14562106;16260602;18407956;21126336;22814378;23749301;24374639;24909858;31189955;32597660;33481703;33491328;9169868", "class_list": "", "function": "ATPase that stimulates 40S and 60S ribosome biogenesis (PubMed:16260602). Also involved in ribosome-associated quality control (RQC) pathway, a pathway that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation: localizes to the ribosomal E-site and stimulates VMS1-dependent tRNA cleavage (PubMed:31189955)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLT5", "ec_number_list": "3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043335 protein unfolding;GO:0042254 ribosome biogenesis;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40024-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40028-1", "uniprot_id": "YEN1_YEAST", "mass": 87364.0, "length": 759, "protein_name": "Holliday junction resolvase YEN1", "gene_name": "YEN1", "organism": "Yeast", "refseq_name": "crossover junction endodeoxyribonuclease", "refseq_ac": "NP_010959", "gene_names_uniprotkb": "YEN1", "gene_names_refseq": "YEN1", "protein_names_uniprotkb": "Holliday junction resolvase YEN1; 3.1.-.-", "protein_names_refseq": "crossover junction endodeoxyribonuclease", "tax_id": 559292, "disease": "", "pathway": " (sce:YER041W)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562106;18407956;19020614;19520826;19779198;20106725;21172663;23749301;24374639;26682650;32597660;33481703;33491328;34928393;9169868", "class_list": "", "function": "Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Involved in DNA-damage repair in vegetative cells., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLU1;Q02463", "ec_number_list": "", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0000400 four-way junction DNA binding;GO:0008409 5'-3' exonuclease activity;GO:0008821 crossover junction DNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40028-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40030-1", "uniprot_id": "ERG28_YEAST", "mass": 17135.0, "length": 148, "protein_name": "Ergosterol biosynthetic protein 28", "gene_name": "ERG28", "organism": "Yeast", "refseq_name": "Erg28p", "refseq_ac": "NP_010962", "gene_names_uniprotkb": "ERG28; BUD18", "gene_names_refseq": "BUD18; ERG28", "protein_names_uniprotkb": "Ergosterol biosynthetic protein 28", "protein_names_refseq": "Erg28p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER044C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11160377;12119386;14562106;15522820;15995173;16847258;17322287;24374639;32679672;9169868", "class_list": "", "function": "Part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:11160377, PubMed:12119386, PubMed:15522820, PubMed:15995173). ERG28 has a role as a scaffold to help anchor the catalytic components of the C-4 demethylation complex ERG25, ERG26 and ERG27 to the endoplasmic reticulum (PubMed:12119386, PubMed:15522820, PubMed:15995173). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis. Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core. In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions. The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis. The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25. Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLU4", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006696 ergosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40030-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40036-1", "uniprot_id": "GIP2_YEAST", "mass": 62319.0, "length": 548, "protein_name": "GLC7-interacting protein 2", "gene_name": "GIP2", "organism": "Yeast", "refseq_name": "Gip2p", "refseq_ac": "NP_010974", "gene_names_uniprotkb": "GIP2", "gene_names_refseq": "GIP2", "protein_names_uniprotkb": "GLC7-interacting protein 2", "protein_names_refseq": "Gip2p", "tax_id": 559292, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (sce:YER054C); (R-SCE-3322077)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "14562106;15665377;17287358;17563356;18407956;19779198;19795423;19823750;21126336;21177495;22814378;23749301;24374639;30516470;33481703;33491328;9169868", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLV7", "ec_number_list": "", "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P40036-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40046-1", "uniprot_id": "VTC1_YEAST", "mass": 14371.0, "length": 129, "protein_name": "Vacuolar transporter chaperone complex subunit 1", "gene_name": "VTC1", "organism": "Yeast", "refseq_name": "Vtc1p", "refseq_ac": "NP_010995", "gene_names_uniprotkb": "VTC1; NRF1; PHM4", "gene_names_refseq": "NRF1; PHM4; VTC1", "protein_names_uniprotkb": "Vacuolar transporter chaperone complex subunit 1; Negative regulator of CDC42 protein 1; Phosphate metabolism protein 4; PolyP polymerase; SPX-dependent polyphosphate polymerase VTC subunit 1; Vacuolar membrane polyphosphate polymerase accessory subunit 1", "protein_names_refseq": "Vtc1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER072W)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10480897;11102525;11823419;12584253;14562106;17079729;19390046;22814378;24374639;25315834;27587415;9169868", "class_list": "", "function": "Accessory subunit of the vacuolar transporter chaperone (VTC) complex. The VTC complex acts as a vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP. VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046). The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:19390046, PubMed:25315834). PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834). VTC1 contributes only 3 transmembrane domains to the complex (Probable). The VTC complex also plays a role in vacuolar membrane fusion (PubMed:10480897, PubMed:11102525, PubMed:11823419, PubMed:12584253). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLX7", "ec_number_list": "", "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007034 vacuolar transport;GO:0042144 vacuole fusion, non-autophagic;GO:0061736 engulfment of target by autophagosome;GO:0006797 polyphosphate metabolic process;GO:0016237 microautophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P40046-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40047-1", "uniprot_id": "ALDH5_YEAST", "mass": 56693.0, "length": 520, "protein_name": "Aldehyde dehydrogenase 5, mitochondrial", "gene_name": "ALD5", "organism": "Yeast", "refseq_name": "aldehyde dehydrogenase (NAD(P)(+)) ALD5", "refseq_ac": "NP_010996", "gene_names_uniprotkb": "ALD5; ALD3; ALDH5", "gene_names_refseq": "ALD5", "protein_names_uniprotkb": "Aldehyde dehydrogenase 5, mitochondrial; 1.2.1.4", "protein_names_refseq": "aldehyde dehydrogenase (NAD(P)(+)) ALD5", "tax_id": 559292, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); isolated microphthalmia 8 (Disease Ontology:DOID:0060841); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); DiGeorge syndrome (Disease Ontology:DOID:11198); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic cancer (Disease Ontology:DOID:1793); brain infarction (Disease Ontology:DOID:3454); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); liver disease (Disease Ontology:DOID:409); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (sce:YER073W); (R-SCE-380612); (R-SCE-5365859); (R-SCE-70350); (R-SCE-71384); (R-SCE-9837999)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10585550;14562095;14562106;14576278;15256563;19795423;19823750;24374639;33481703;33491328;9059631;9169868;9473035", "class_list": "", "function": "Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLX8", "ec_number_list": "3.5.3.1;7.1.2.2;2.3.3.1;4.2.1.2;3.6.4.10;4.98.1.1;4.2.1.3;1.2.4.2;1.1.1.37;1.2.4.1;3.4.21.53;2.3.1.41;1.2.1.4;1.2.1.5;6.1.1.5;2.3.3.10", "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0140088 acetaldehyde dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006068 ethanol catabolic process;GO:0019413 acetate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40047-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40048-1", "uniprot_id": "PTP3_YEAST", "mass": 105224.0, "length": 928, "protein_name": "Tyrosine-protein phosphatase 3", "gene_name": "PTP3", "organism": "Yeast", "refseq_name": "tyrosine protein phosphatase PTP3", "refseq_ac": "NP_010998", "gene_names_uniprotkb": "PTP3", "gene_names_refseq": "PTP3", "protein_names_uniprotkb": "Tyrosine-protein phosphatase 3; 3.1.3.48; PTPase 3; Protein-tyrosine phosphatase 3", "protein_names_refseq": "tyrosine protein phosphatase PTP3", "tax_id": 559292, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); severe combined immunodeficiency 105 (Disease Ontology:DOID:0061074); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); thrombocytopenia (Disease Ontology:DOID:1588); status epilepticus (Disease Ontology:DOID:1824); hyperinsulinism (Disease Ontology:DOID:2018); multiple sclerosis (Disease Ontology:DOID:2377); nephrosis (Disease Ontology:DOID:2527); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); severe combined immunodeficiency (Disease Ontology:DOID:627); retinal degeneration (Disease Ontology:DOID:8466); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YER075C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562095;14562106;17287358;17330950;17563356;18407956;19779198;19795423;19823750;20489023;23749301;24374639;32597660;33481703;33491328;9032256;9169868;9211927;9224718", "class_list": "", "function": "Major phosphatase responsible for tyrosine dephosphorylation of MAP kinases FUS3 and HOG1 to inactivate their activity; it also has important roles, along with MSG5, in the inactivation of FUS3 following pheromone stimulation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3DLY1", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.2", "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0071474 cellular hyperosmotic response;GO:0043937 regulation of sporulation;GO:0071507 pheromone response MAPK cascade;GO:0071852 fungal-type cell wall organization or biogenesis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40048-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40054-1", "uniprot_id": "SERA_YEAST", "mass": 51193.0, "length": 469, "protein_name": "D-3-phosphoglycerate dehydrogenase 1", "gene_name": "SER3", "organism": "Yeast", "refseq_name": "phosphoglycerate dehydrogenase SER3", "refseq_ac": "NP_011004", "gene_names_uniprotkb": "SER3", "gene_names_refseq": "SER3", "protein_names_uniprotkb": "D-3-phosphoglycerate dehydrogenase 1; 1.1.1.399; 1.1.1.95; 2-oxoglutarate reductase; 3-PGDH 1", "protein_names_refseq": "phosphoglycerate dehydrogenase SER3", "tax_id": 559292, "disease": "PHGDH deficiency (Disease Ontology:DOID:0050722); Neu-Laxova syndrome 1 (Disease Ontology:DOID:0080076); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YER081W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;18407956;24374639;26774271;33491328;9169868", "class_list": "", "function": "Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLY8", "ec_number_list": "1.1.1.399;1.1.1.95", "go_molecular_function": "GO:0051287 NAD binding;GO:0004617 phosphoglycerate dehydrogenase activity;GO:0047545 (S)-2-hydroxyglutarate dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0040029 epigenetic regulation of gene expression;GO:0006564 L-serine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40054-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40055-1", "uniprot_id": "UTP7_YEAST", "mass": 62317.0, "length": 554, "protein_name": "U3 small nucleolar RNA-associated protein 7", "gene_name": "UTP7", "organism": "Yeast", "refseq_name": "Utp7p", "refseq_ac": "NP_011005", "gene_names_uniprotkb": "UTP7; KRE31", "gene_names_refseq": "KRE31; UTP7", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 7; U three protein 7; U3 snoRNA-associated protein 7", "protein_names_refseq": "Utp7p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER082C); (R-SCE-6791226)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12068309;14562106;24374639;33481703;33491328;9169868", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3DLY9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40055-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40056-1", "uniprot_id": "GET2_YEAST", "mass": 31493.0, "length": 285, "protein_name": "Golgi to ER traffic protein 2", "gene_name": "GET2", "organism": "Yeast", "refseq_name": "GET complex subunit GET2", "refseq_ac": "NP_011006", "gene_names_uniprotkb": "GET2; HUR2; RMD7", "gene_names_refseq": "GET2; HUR2; RMD7", "protein_names_uniprotkb": "Golgi to ER traffic protein 2; Guided entry of tail-anchored proteins 2; Hydroxyurea resistance protein 2; Required for meiotic nuclear division protein 7", "protein_names_refseq": "GET complex subunit GET2", "tax_id": 559292, "disease": "", "pathway": " (sce:YER083C)", "pathway_count": 1, "publication_count": 31, "publication_id_list": "10929718;11805837;12586695;12615994;12748633;14562095;16269340;16816426;17287358;17330950;17563356;18407956;18724936;19779198;19795423;19823750;20702584;21719644;21835666;22814378;23749301;24374639;24392163;28270554;31208443;32597660;32910895;33481703;33491328;34965436;9169868", "class_list": "", "function": "Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function., [UniProtKB, PubMed, PubMed, PubMed, HAMAP, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D3DLZ0", "ec_number_list": "", "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0043529 GET complex", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0000423 mitophagy;GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P40056-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40059-1", "uniprot_id": "DOT6_YEAST", "mass": 73048.0, "length": 670, "protein_name": "Transcriptional regulatory protein DOT6", "gene_name": "DOT6", "organism": "Yeast", "refseq_name": "Dot6p", "refseq_ac": "NP_011012", "gene_names_uniprotkb": "DOT6; PBF2", "gene_names_refseq": "DOT6; PBF2", "protein_names_uniprotkb": "Transcriptional regulatory protein DOT6; Disrupter of telomere silencing protein 6; PAC-binding factor 2", "protein_names_refseq": "Dot6p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER088C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14562106;17287358;17330950;18407956;19040720;19111667;19158363;19684113;19779198;20702584;21126336;21177495;22218487;23749301;24374639;24909858;30516470;32597660;33229814;33481703;33491328;34965436;9169868;9755194", "class_list": "", "function": "Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. DOT6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 19, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 19, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 19, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 81, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "D3DLZ5", "ec_number_list": "", "go_molecular_function": "GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region;GO:0070210 Rpd3L-Expanded complex", "go_biological_process": "GO:0031509 subtelomeric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000183 rDNA heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 4.5, "record_id": "P40059-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40064-1", "uniprot_id": "NU157_YEAST", "mass": 156649.0, "length": 1391, "protein_name": "Nucleoporin NUP157", "gene_name": "NUP157", "organism": "Yeast", "refseq_name": "Nup157p", "refseq_ac": "NP_011031", "gene_names_uniprotkb": "NUP157", "gene_names_refseq": "NUP157", "protein_names_uniprotkb": "Nucleoporin NUP157; Nuclear pore protein NUP157", "protein_names_refseq": "Nup157p", "tax_id": 559292, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650)", "pathway": " (sce:YER105C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10684247;10688190;12473689;12791264;14562106;18407956;21126336;22031224;22814378;23749301;24374639;32597660;33481703;33491328;8522578;9169868", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM12", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044611 nuclear pore inner ring", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0051292 nuclear pore complex assembly;GO:0051028 mRNA transport;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0036228 protein localization to nuclear inner membrane", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40064-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40066-1", "uniprot_id": "GLE2_YEAST", "mass": 40523.0, "length": 365, "protein_name": "mRNA export factor GLE2", "gene_name": "GLE2", "organism": "Yeast", "refseq_name": "RNA export factor GLE2", "refseq_ac": "NP_011033", "gene_names_uniprotkb": "GLE2; RAE1", "gene_names_refseq": "GLE2; RAE1", "protein_names_uniprotkb": "mRNA export factor GLE2; Nuclear pore protein GLE2; Nucleoporin GLE2; poly(A) RNA export protein RAE1", "protein_names_refseq": "RNA export factor GLE2", "tax_id": 559292, "disease": "", "pathway": " (sce:YER107C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10684247;10801828;11689687;12791264;14562106;17322287;18407956;23749301;24374639;33229814;33481703;33491328;8970155;9169868;9463388", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically important for nuclear mRNA export., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D3DM14", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0032185 septin cytoskeleton organization;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P40066-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40069-1", "uniprot_id": "IMB4_YEAST", "mass": 122601.0, "length": 1113, "protein_name": "Importin subunit beta-4", "gene_name": "KAP123", "organism": "Yeast", "refseq_name": "karyopherin KAP123", "refseq_ac": "NP_011035", "gene_names_uniprotkb": "KAP123; YRB4", "gene_names_refseq": "KAP123; YRB4", "protein_names_uniprotkb": "Importin subunit beta-4; Importin-123; Karyopherin subunit beta-4; Karyopherin-123; Ran-binding protein YRB4", "protein_names_refseq": "karyopherin KAP123", "tax_id": 559292, "disease": "", "pathway": " (sce:YER110C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "11274141;11423015;11694505;12612077;14562106;14690591;18407956;19795423;19823750;21126336;23541588;24374639;33481703;33491328;8849456;9169868;9182759;9238021;9321403", "class_list": "", "function": "Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Its predominant cargo substrate seems to be ribosomal proteins (PubMed:9321403). Required for import of the ribosomal assembly factor NMD3 (PubMed:12612077). May be involved in nuclear transport of YAP1 (PubMed:11274141). Mediates the nuclear import of histones H3 and H4 (PubMed:11694505). Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11423015). At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo (PubMed:9321403). The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11423015)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM16", "ec_number_list": "", "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0051028 mRNA transport;GO:0006607 NLS-bearing protein import into nucleus;GO:0006606 protein import into nucleus;GO:2000220 regulation of pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40069-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40077-1", "uniprot_id": "DSE1_YEAST", "mass": 63999.0, "length": 573, "protein_name": "Protein DSE1", "gene_name": "DSE1", "organism": "Yeast", "refseq_name": "Dse1p", "refseq_ac": "NP_011050", "gene_names_uniprotkb": "DSE1; SYGP-ORF48", "gene_names_refseq": "DSE1", "protein_names_uniprotkb": "Protein DSE1; Daughter-specific expression protein 1", "protein_names_refseq": "Dse1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YER124C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11309124;11747810;14562095;14562106;14709718;16820445;22106047;23749301;24374639;32597660;33481703;33491328;9169868", "class_list": "", "function": "Involved in cell wall metabolism and required for the separation of the mother and daughter cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM30", "ec_number_list": "", "go_molecular_function": "GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005935 cellular bud neck", "go_biological_process": "GO:0000920 septum digestion after cytokinesis;GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion;GO:0001403 invasive growth in response to glucose limitation;GO:0071555 cell wall organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40077-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40084-1", "uniprot_id": "RTR1_YEAST", "mass": 26240.0, "length": 226, "protein_name": "RNA polymerase II subunit B1 CTD phosphatase RTR1", "gene_name": "RTR1", "organism": "Yeast", "refseq_name": "RNA polymerase II subunit B1 CTD phosphatase RTR1", "refseq_ac": "NP_011066", "gene_names_uniprotkb": "RTR1", "gene_names_refseq": "RTR1", "protein_names_uniprotkb": "RNA polymerase II subunit B1 CTD phosphatase RTR1; 3.1.3.16; RNA polymerase II-associated protein 2 homolog RTR1; Regulator of transcription 1", "protein_names_refseq": "RNA polymerase II subunit B1 CTD phosphatase RTR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YER139C); (R-SCE-6807505)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14562095;14562106;18408053;19394294;19795423;19823750;24374639;33481703;33491328;9169868", "class_list": "", "function": "RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that dephosphorylates 'Ser-5' of the CTD and regulates RNA polymerase II during the transition from 'Ser-5' to 'Ser-2' phosphorylation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM46", "ec_number_list": "2.7.7.6;2.7.11.23;3.1.3.16;2.7.11.22;3.1.3.43;3.1.3.48", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043175 RNA polymerase core enzyme binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40084-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40086-1", "uniprot_id": "COX15_YEAST", "mass": 54658.0, "length": 486, "protein_name": "Heme A synthase COX15", "gene_name": "COX15", "organism": "Yeast", "refseq_name": "Cox15p", "refseq_ac": "NP_011068", "gene_names_uniprotkb": "COX15", "gene_names_refseq": "COX15", "protein_names_uniprotkb": "Heme A synthase COX15; 1.17.99.9; Cytochrome c oxidase assembly protein COX15; HAS", "protein_names_refseq": "Cox15p", "tax_id": 559292, "disease": "mitochondrial complex IV deficiency nuclear type 6 (Disease Ontology:DOID:0080358); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); ovarian dysfunction (Disease Ontology:DOID:1414); Leigh disease (Disease Ontology:DOID:3652)", "pathway": " (sce:YER141W); (R-SCE-189451)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11248251;11788607;11959116;18953022;23979592;24374639;26940873;27998984;29897761;30181213;33491328;37348627;9169868;9228094", "class_list": "", "function": "Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS/COX10) and heme A synthase (HAS/COX15). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin YAH1 and ferredoxin reductase ARH1. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A (PubMed:11248251, PubMed:11788607, PubMed:37348627, PubMed:9228094). May also play a secondary role in CcO assembly. Plays a role in the maturation of COX1, the heme A-containing structural CcO subunit, possibly by interacting with the COX1-containing sub-assembly complexes that form prior to heme A insertion (PubMed:23979592, PubMed:27998984, PubMed:30181213). May also positively regulate the upstream enzymatic reaction, farnesylation of heme B by HOS/COX10 (PubMed:11959116, PubMed:18953022)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM48", "ec_number_list": "1.17.99.9", "go_molecular_function": "GO:0046872 metal ion binding;GO:0120547 heme A synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006784 heme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40086-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40088-1", "uniprot_id": "FTR1_YEAST", "mass": 45722.0, "length": 404, "protein_name": "Plasma membrane iron permease", "gene_name": "FTR1", "organism": "Yeast", "refseq_name": "high-affinity iron permease FTR1", "refseq_ac": "NP_011072", "gene_names_uniprotkb": "FTR1", "gene_names_refseq": "FTR1", "protein_names_uniprotkb": "Plasma membrane iron permease", "protein_names_refseq": "high-affinity iron permease FTR1", "tax_id": 559292, "disease": "", "pathway": " (sce:YER145C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;15665377;19779198;19795423;19823750;23749301;24374639;32597660;33491328;8599111;9169868", "class_list": "", "function": "Permease for high affinity iron uptake., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM52", "ec_number_list": "", "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0033573 high-affinity iron permease complex", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0098706 iron ion import across cell outer membrane;GO:1901684 arsenate ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P40088-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40089-1", "uniprot_id": "LSM5_YEAST", "mass": 10423.0, "length": 93, "protein_name": "LSM complex subunit LSM5", "gene_name": "LSM5", "organism": "Yeast", "refseq_name": "RNA-binding protein LSM5", "refseq_ac": "NP_011073", "gene_names_uniprotkb": "LSM5", "gene_names_refseq": "LSM5", "protein_names_uniprotkb": "LSM complex subunit LSM5", "protein_names_refseq": "RNA-binding protein LSM5", "tax_id": 559292, "disease": "", "pathway": " (sce:YER146W); (R-SCE-430039)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10369684;10428970;10449419;10747033;10761922;12077351;12438310;15075370;15485930;17322287;24139796;24240276;24374639;24513854;29717126;30059503;33491328;9169868", "class_list": "", "function": "Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner (PubMed:10747033, PubMed:12077351, PubMed:12438310, PubMed:24513854). Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step (PubMed:10747033, PubMed:10761922, PubMed:24513854). Together with PAT1, the LSM1-LSM7 complex binds to osmotic stress-activated mRNAs to attenuate the osmotic stress response, probably by limiting ribosome access to the mRNA and consequently translation (PubMed:30059503). Component of the nuclear LSM2-LSM8 complex, which is involved in spliceosome assembly (PubMed:10747033, PubMed:12077351, PubMed:12438310). The LSM2-LSM8 complex plays a role in the biogenesis of the spliceosomal U4/U6-U5 tri-snRNP complex by accelerating PRP24-mediated annealing of U4/U6 di-snRNA (PubMed:10747033, PubMed:24240276, PubMed:29717126). The LSM2-LSM8 complex binds U6 snRNA terminating with a non-cyclic 3' phosphate group (PubMed:29717126). LSM2-LSM8 is probably also involved in degradation of nuclear pre-mRNA by targeting them for decapping (PubMed:15485930). LSM2-LSM8 could be involved in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA, although involvement may be indirect (PubMed:12077351, PubMed:12438310, PubMed:15075370). In a complex that probably contains LSM2-LSM7, but not LSM1 or LSM8, associates with the precursor of the RNA component of RNase P (pre-P RNA) and may be involved in maturing pre-P RNA; the complex also associates with snoRNA SNR5 (PubMed:10369684, PubMed:15075370)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM53", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0000932 P-body;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0008033 tRNA processing;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0000398 mRNA splicing, via spliceosome;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P40089-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40090-1", "uniprot_id": "SCC4_YEAST", "mass": 72141.0, "length": 624, "protein_name": "MAU2 chromatid cohesion factor homolog", "gene_name": "SCC4", "organism": "Yeast", "refseq_name": "cohesin-loading factor complex subunit SCC4", "refseq_ac": "NP_011074", "gene_names_uniprotkb": "SCC4", "gene_names_refseq": "SCC4", "protein_names_uniprotkb": "MAU2 chromatid cohesion factor homolog; Sister chromatid cohesion protein 4", "protein_names_refseq": "cohesin-loading factor complex subunit SCC4", "tax_id": 559292, "disease": "", "pathway": " (sce:YER147C)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10882066;14562106;23749301;24374639;25173104;26038942;33491328;9169868", "class_list": "", "function": "Involved in sister chromatid cohesion (PubMed:10882066). Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes (PubMed:10882066, PubMed:26038942). Binds to the nucleosome-free promoter regions of ribosomal protein genes and tRNA genes (PubMed:25173104)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM54", "ec_number_list": "", "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0000785 chromatin;GO:0032116 SMC loading complex", "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0007076 mitotic chromosome condensation;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40090-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40094-1", "uniprot_id": "COG3_YEAST", "mass": 92544.0, "length": 801, "protein_name": "Conserved oligomeric Golgi complex subunit 3", "gene_name": "COG3", "organism": "Yeast", "refseq_name": "Golgi transport complex subunit COG3", "refseq_ac": "NP_011084", "gene_names_uniprotkb": "COG3; GRD20; SEC34", "gene_names_refseq": "COG3; GRD20; SEC34", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 3; COG complex subunit 3; Component of oligomeric Golgi complex 3; Protein SEC34", "protein_names_refseq": "Golgi transport complex subunit COG3", "tax_id": 559292, "disease": "congenital disorder of glycosylation type IIbb (Disease Ontology:DOID:0051047)", "pathway": " (sce:YER157W)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10562277;10588657;11703943;12006647;14562106;15047703;15665377;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;23749301;24374639;24909858;30516470;32597660;33481703;33491328;9169868", "class_list": "", "function": "Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG3 is also involved in actin cytoskeleton organization., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM64", "ec_number_list": "", "go_molecular_function": "GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005801 cis-Golgi network;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006914 autophagy;GO:0007030 Golgi organization;GO:0000301 retrograde transport, vesicle recycling within Golgi", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P40094-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40096-1", "uniprot_id": "NCB1_YEAST", "mass": 15517.0, "length": 142, "protein_name": "Negative cofactor 2 complex subunit alpha", "gene_name": "BUR6", "organism": "Yeast", "refseq_name": "negative cofactor 2 transcription regulator complex subunit BUR6", "refseq_ac": "NP_011086", "gene_names_uniprotkb": "BUR6; NCB1", "gene_names_refseq": "BUR6; NCB1", "protein_names_uniprotkb": "Negative cofactor 2 complex subunit alpha; NC2 complex subunit alpha; Transcription repressor BUR6", "protein_names_refseq": "negative cofactor 2 transcription regulator complex subunit BUR6", "tax_id": 559292, "disease": "", "pathway": " (sce:YER159C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12237409;12502746;14562095;14562106;17322287;18407956;19684113;19795423;19823750;21126336;23749301;24374639;32597660;33481703;33491328;8948634;9023340;9096360;9169868", "class_list": "", "function": "Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex. The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DM66", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017054 negative cofactor 2 complex", "go_biological_process": "GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40096-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40416-1", "uniprot_id": "ATM1_YEAST", "mass": 77522.0, "length": 690, "protein_name": "Iron-sulfur clusters transporter ATM1, mitochondrial", "gene_name": "ATM1", "organism": "Yeast", "refseq_name": "ATP-binding cassette Fe/S cluster precursor transporter ATM1", "refseq_ac": "NP_014030", "gene_names_uniprotkb": "ATM1; MDY; YM9952.03C", "gene_names_refseq": "ATM1", "protein_names_uniprotkb": "Iron-sulfur clusters transporter ATM1, mitochondrial; 7.-.-.-", "protein_names_refseq": "ATP-binding cassette Fe/S cluster precursor transporter ATM1", "tax_id": 559292, "disease": "X-linked sideroblastic anemia with ataxia (Disease Ontology:DOID:0050554); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (sce:YMR301C); (R-SCE-1369007)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10406803;14562106;15225610;21126336;24374639;24604199;25006243;31040179;33491328;7828591;9169872;9428742", "class_list": "", "function": "Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (PubMed:10406803, PubMed:25006243, PubMed:31040179). Hydrolyzes ATP (PubMed:24604199, PubMed:25006243). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (PubMed:24604199, PubMed:25006243, PubMed:31040179)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0C8", "ec_number_list": "7.-.-.-;1.18.1.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:1990542 mitochondrial transmembrane transport;GO:0140466 iron-sulfur cluster export from the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P40416-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P49166-1", "uniprot_id": "RL37A_YEAST", "mass": 9850.0, "length": 88, "protein_name": "Large ribosomal subunit protein eL37A", "gene_name": "RPL37A", "organism": "Yeast", "refseq_name": "60S ribosomal protein eL37 RPL37A", "refseq_ac": "NP_013286", "gene_names_uniprotkb": "RPL37A; L9470.6; RPL35A", "gene_names_refseq": "RPL37A", "protein_names_uniprotkb": "Large ribosomal subunit protein eL37A; 60S ribosomal protein L37-A; L43; YL35; YP55", "protein_names_refseq": "60S ribosomal protein eL37 RPL37A", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR185W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "11701127;14562095;14562106;14976550;21109664;22096102;23749301;24374639;24524803;32597660;33481703;33491328;9169871;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYI8", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0030687 preribosome, large subunit precursor;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P49166-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P52553-1", "uniprot_id": "PFD6_YEAST", "mass": 13284.0, "length": 114, "protein_name": "Prefoldin subunit 6", "gene_name": "YKE2", "organism": "Yeast", "refseq_name": "tubulin-binding prefolding complex subunit YKE2", "refseq_ac": "NP_013301", "gene_names_uniprotkb": "YKE2; GIM1; L8167.8; PFD6", "gene_names_refseq": "GIM1; PFD6; YKE2", "protein_names_uniprotkb": "Prefoldin subunit 6; Genes involved in microtubule biogenesis protein 1; Gim complex subunit 1; GimC subunit 1", "protein_names_refseq": "tubulin-binding prefolding complex subunit YKE2", "tax_id": 559292, "disease": "", "pathway": " (sce:YLR200W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562106;21126336;22814378;23749301;24374639;33481703;33491328;7828874;9169871;9463374;9878052", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYK2", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0051131 chaperone-mediated protein complex assembly;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P52553-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53137-1", "uniprot_id": "CUE3_YEAST", "mass": 72043.0, "length": 624, "protein_name": "RQC trigger complex subunit CUE3", "gene_name": "CUE3", "organism": "Yeast", "refseq_name": "Cue3p", "refseq_ac": "NP_011405", "gene_names_uniprotkb": "CUE3; G3060; RQT3", "gene_names_refseq": "CUE3; RQT3", "protein_names_uniprotkb": "RQC trigger complex subunit CUE3; CUE domain-containing protein 3; Coupling of ubiquitin conjugation to ER degradation protein 3", "protein_names_refseq": "Cue3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL110C)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "14562095;14562106;18407956;19779198;21126336;24374639;28223409;28757607;32203490;32597660;33481703;33491328;36627279;9046090;9169869", "class_list": "", "function": "Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28223409, PubMed:28757607, PubMed:32203490, PubMed:36627279). Specifically recognizes and binds RPS20/uS10 ubiquitinated by HEL2, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:28757607, PubMed:36627279)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU37", "ec_number_list": "", "go_molecular_function": "GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53137-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53251-1", "uniprot_id": "SLX9_YEAST", "mass": 24069.0, "length": 210, "protein_name": "Ribosome biogenesis protein SLX9", "gene_name": "SLX9", "organism": "Yeast", "refseq_name": "Slx9p", "refseq_ac": "NP_011595", "gene_names_uniprotkb": "SLX9", "gene_names_refseq": "SLX9", "protein_names_uniprotkb": "Ribosome biogenesis protein SLX9", "protein_names_refseq": "Slx9p", "tax_id": 559292, "disease": "", "pathway": " (sce:YGR081C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14562095;14562106;14566339;16943074;17018574;18407956;19795423;19823750;24374639;33491328;9169869", "class_list": "", "function": "Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": "", "go_molecular_function": "GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53251-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53759-1", "uniprot_id": "DUS1_YEAST", "mass": 48131.0, "length": 423, "protein_name": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]", "gene_name": "DUS1", "organism": "Yeast", "refseq_name": "tRNA dihydrouridine synthase", "refseq_ac": "NP_013631", "gene_names_uniprotkb": "DUS1", "gene_names_refseq": "DUS1", "protein_names_uniprotkb": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]; 1.3.1.-; 1.3.1.88; mRNA-dihydrouridine synthase DUS1; tRNA-dihydrouridine synthase 1", "protein_names_refseq": "tRNA dihydrouridine synthase", "tax_id": 559292, "disease": "", "pathway": " (sce:YML080W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12003496;14562106;14970222;22814378;24374639;9169872", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:12003496, PubMed:14970222). Specifically modifies U16 and U17 in cytoplasmic tRNAs (PubMed:12003496, PubMed:14970222). Also able to mediate dihydrouridylation of some mRNAs, thereby affecting their translation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0K3", "ec_number_list": "1.3.1.-;1.3.1.91;1.3.1.88;1.3.1.89;1.3.1.90", "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0106414 mRNA dihydrouridine synthase activity;GO:0102262 tRNA-dihydrouridine16 synthase activity;GO:0102263 tRNA-dihydrouridine17 synthase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53759-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06217-1", "uniprot_id": "SMD2_YEAST", "mass": 12853.0, "length": 110, "protein_name": "Small nuclear ribonucleoprotein Sm D2", "gene_name": "SMD2", "organism": "Yeast", "refseq_name": "mRNA splicing protein SMD2", "refseq_ac": "NP_013377", "gene_names_uniprotkb": "SMD2; L9328.5", "gene_names_refseq": "SMD2", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D2; Sm-D2; snRNP core protein D2", "protein_names_refseq": "mRNA splicing protein SMD2", "tax_id": 559292, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (sce:YLR275W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10369684;10449419;11302706;11804584;11884590;14562106;24374639;33491328;9012791;9169871;9528767", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VYS2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q06217-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q06696-1", "uniprot_id": "VPS36_YEAST", "mass": 64018.0, "length": 566, "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "VPS36", "organism": "Yeast", "refseq_name": "ESCRT-II subunit protein VPS36", "refseq_ac": "NP_013521", "gene_names_uniprotkb": "VPS36; GRD12; VAC3; VPL11", "gene_names_refseq": "GRD12; VAC3; VPL11; VPS36", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36", "protein_names_refseq": "ESCRT-II subunit protein VPS36", "tax_id": 559292, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (sce:YLR417W); (R-SCE-917729)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12194858;14562106;15029239;15329733;15469844;24374639;33491328;9169871", "class_list": "", "function": "Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (PubMed:12194858, PubMed:15329733, PubMed:15469844). The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (PubMed:12194858). The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (PubMed:12194858). Involved in the trafficking of the plasma membrane ATPase (PubMed:12194858). Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (PubMed:15029239)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ53", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0031902 late endosome membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0045053 protein retention in Golgi apparatus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016236 macroautophagy;GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06696-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P31412-1", "uniprot_id": "VATC_YEAST", "mass": 44189.0, "length": 392, "protein_name": "V-type proton ATPase subunit C", "gene_name": "VMA5", "organism": "Yeast", "refseq_name": "H(+)-transporting V1 sector ATPase subunit C", "refseq_ac": "NP_012843", "gene_names_uniprotkb": "VMA5; VAT3; VATC; YKL410", "gene_names_refseq": "CSL5; VAT3; VMA5", "protein_names_uniprotkb": "V-type proton ATPase subunit C; V-ATPase 42 kDa subunit; V-ATPase subunit C; Vacuolar proton pump subunit C", "protein_names_refseq": "H(+)-transporting V1 sector ATPase subunit C", "tax_id": 559292, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); cancer (Disease Ontology:DOID:162); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (sce:YKL080W); (R-SCE-1222556); (R-SCE-77387); (R-SCE-917977); (R-SCE-9639288)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "10781598;11777935;14562095;14562106;15540116;15751969;15792803;1730668;19779198;19795423;19823750;21126336;24374639;25971514;33481703;33491328;8196765;8203165;8416931", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:10781598, PubMed:11777935, PubMed:1730668, PubMed:8416931). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:8416931). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (PubMed:15792803). Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section (PubMed:15792803)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VXK7", "ec_number_list": "", "go_molecular_function": "GO:0005524 ATP binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P31412-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32074-1", "uniprot_id": "COPG_YEAST", "mass": 104831.0, "length": 935, "protein_name": "Coatomer subunit gamma", "gene_name": "SEC21", "organism": "Yeast", "refseq_name": "coatomer subunit gamma", "refseq_ac": "NP_014112", "gene_names_uniprotkb": "SEC21; N0543", "gene_names_refseq": "SEC21", "protein_names_uniprotkb": "Coatomer subunit gamma; Gamma-COP; Gamma-coat protein", "protein_names_refseq": "coatomer subunit gamma", "tax_id": 559292, "disease": "immunodeficiency 128 (Disease Ontology:DOID:0061093); combined immunodeficiency (Disease Ontology:DOID:0111962); polyclonal hypergammaglobulinemia (Disease Ontology:DOID:2344)", "pathway": " (sce:YNL287W); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 24, "publication_id_list": "14562095;14562106;1461285;17101773;17563356;18407956;19039328;19726565;19779198;19795423;19823750;20702584;21126336;21177495;22106047;23749301;24374639;27821475;30516470;32597660;33481703;33491328;8001155;9169873", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Q6", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0070971 endoplasmic reticulum exit site;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0009306 protein secretion;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P32074-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32461-1", "uniprot_id": "DPH2_YEAST", "mass": 59775.0, "length": 534, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2", "gene_name": "DPH2", "organism": "Yeast", "refseq_name": "2-(3-amino-3-carboxypropyl)histidine synthase", "refseq_ac": "NP_012730", "gene_names_uniprotkb": "DPH2", "gene_names_refseq": "DPH2", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2", "protein_names_refseq": "2-(3-amino-3-carboxypropyl)histidine synthase", "tax_id": 559292, "disease": "diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 2 (Disease Ontology:DOID:0070478)", "pathway": " (sce:YKL191W); (R-SCE-5358493)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "12940988;14562095;14562106;15485916;18407956;18627462;19779198;22814378;23645155;24374639;24422557;27694803;31463593;32576952;33481703;33491328;34154323;8132612;8154185;8196765;8394042;8406038", "class_list": "", "function": "Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:32576952, PubMed:34154323, PubMed:8406038). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323, PubMed:8406038). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (PubMed:31463593)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VX09", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0120513 2-(3-amino-3-carboxypropyl)histidine synthase complex", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32461-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32563-1", "uniprot_id": "VPP1_YEAST", "mass": 95529.0, "length": 840, "protein_name": "V-type proton ATPase subunit a, vacuolar isoform", "gene_name": "VPH1", "organism": "Yeast", "refseq_name": "H(+)-transporting V0 sector ATPase subunit a", "refseq_ac": "NP_014913", "gene_names_uniprotkb": "VPH1", "gene_names_refseq": "VPH1", "protein_names_uniprotkb": "V-type proton ATPase subunit a, vacuolar isoform; V-ATPase 95 kDa subunit; V-ATPase a 1 subunit; Vacuolar pH protein 1; Vacuolar proton pump a subunit; Vacuolar proton translocating ATPase subunit a 1", "protein_names_refseq": "H(+)-transporting V0 sector ATPase subunit a", "tax_id": 559292, "disease": "autosomal recessive distal renal tubular acidosis 3 with or without sensorineural hearing loss (Disease Ontology:DOID:0061166); autosomal recessive cutis laxa type IIA (Disease Ontology:DOID:0070134); developmental and epileptic encephalopathy 104 (Disease Ontology:DOID:0070390); autosomal recessive osteopetrosis 1 (Disease Ontology:DOID:0110942); wrinkly skin syndrome (Disease Ontology:DOID:0112171); clubfoot (Disease Ontology:DOID:11836); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YOR270C); (R-SCE-1222556); (R-SCE-6798695); (R-SCE-77387); (R-SCE-917977); (R-SCE-9639288)", "pathway_count": 6, "publication_count": 22, "publication_id_list": "10329659;10473553;11278748;1385813;14562095;14562106;1491220;16847258;18407956;21832060;22814378;24374639;25971514;27776355;29526695;33481703;33491328;8798414;8896271;9153759;9169874;9506970", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:11278748, PubMed:1491220, PubMed:8798414). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:11278748, PubMed:1491220). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:11278748, PubMed:8798414)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W2X0", "ec_number_list": "", "go_molecular_function": "GO:0051117 ATPase binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0045121 membrane raft;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0071469 cellular response to alkaline pH;GO:0071474 cellular hyperosmotic response;GO:1903778 protein localization to vacuolar membrane;GO:0006797 polyphosphate metabolic process;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P32563-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32800-1", "uniprot_id": "PEX2_YEAST", "mass": 30752.0, "length": 271, "protein_name": "Peroxisomal biogenesis factor 2", "gene_name": "PEX2", "organism": "Yeast", "refseq_name": "ubiquitin-protein ligase peroxin 2", "refseq_ac": "NP_012325", "gene_names_uniprotkb": "PEX2; CRT1; HRA271; J0240; PAS5", "gene_names_refseq": "CRT1; PAS5; PEX2", "protein_names_uniprotkb": "Peroxisomal biogenesis factor 2; 2.3.2.36; Peroxin-2", "protein_names_refseq": "ubiquitin-protein ligase peroxin 2", "tax_id": 559292, "disease": "peroxisome biogenesis disorder 5A (Disease Ontology:DOID:0080480); Peroxisome biogenesis disorder 5B (Disease Ontology:DOID:0081434); Zellweger syndrome (Disease Ontology:DOID:905); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (sce:YJL210W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12876220;14562106;19687296;19779198;22471590;24374639;33491328;35768507;7725802;8641269;8686377", "class_list": "", "function": "E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:19687296, PubMed:22471590, PubMed:35768507). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (PubMed:35768507). PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase (PubMed:35768507). PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-6', a modification that acts as a signal for PEX5 extraction into the cytosol (PubMed:35768507)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVY4", "ec_number_list": "", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0016558 protein import into peroxisome matrix;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P32800-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P32916-1", "uniprot_id": "SRPR_YEAST", "mass": 69278.0, "length": 621, "protein_name": "Signal recognition particle receptor subunit alpha homolog", "gene_name": "SRP101", "organism": "Yeast", "refseq_name": "signal recognition particle receptor subunit alpha", "refseq_ac": "NP_010578", "gene_names_uniprotkb": "SRP101; D9819.3", "gene_names_refseq": "SRP101", "protein_names_uniprotkb": "Signal recognition particle receptor subunit alpha homolog; DP-alpha; Docking protein alpha; SR-alpha", "protein_names_refseq": "signal recognition particle receptor subunit alpha", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR292C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "12654246;1327299;14562106;18407956;19779198;19795423;19823750;23749301;24374639;32597660;33481703;33491328;9169867;9679135", "class_list": "", "function": "Component of the SRP (signal recognition particle) receptor (SR). Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. GTP hydrolysis may enhance the fidelity of and provide unidirectionality to the targeting reaction. It is important but not essential for cell growth. May be directly involved in mitochondrial protein import., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VSS1;Q05553", "ec_number_list": "", "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005785 signal recognition particle receptor complex;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32916-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P33309-1", "uniprot_id": "DOM34_YEAST", "mass": 44058.0, "length": 386, "protein_name": "Protein DOM34", "gene_name": "DOM34", "organism": "Yeast", "refseq_name": "ribosome dissociation factor DOM34", "refseq_ac": "NP_014397", "gene_names_uniprotkb": "DOM34; N2016", "gene_names_refseq": "DOM34", "protein_names_uniprotkb": "Protein DOM34", "protein_names_refseq": "ribosome dissociation factor DOM34", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL001W); (R-SCE-9954714)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11909951;14562095;14562106;16554824;17889667;18180287;19420139;20947765;21102444;21623367;24374639;27995908;7941739;7985421;8402262;9169873", "class_list": "", "function": "Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:16554824, PubMed:17889667, PubMed:18180287, PubMed:19420139, PubMed:20947765, PubMed:21102444). In the Dom34-Hbs1 complex, DOM34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:16554824, PubMed:20947765). Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:20947765). The Dom34-Hbs1 complex is also involved in non-functional rRNA decay (PubMed:21102444)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W1H6", "ec_number_list": "", "go_molecular_function": "GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:1990533 Dom34-Hbs1 complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0070651 nonfunctional rRNA decay;GO:0071025 RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P33309-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40487-1", "uniprot_id": "DPH1_YEAST", "mass": 48311.0, "length": 425, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1", "gene_name": "DPH1", "organism": "Yeast", "refseq_name": "2-(3-amino-3-carboxypropyl)histidine synthase", "refseq_ac": "NP_012163", "gene_names_uniprotkb": "DPH1", "gene_names_refseq": "DPH1", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; 2.5.1.108; Diphthamide biosynthesis protein 1; Diphtheria toxin resistance protein 1; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1", "protein_names_refseq": "2-(3-amino-3-carboxypropyl)histidine synthase", "tax_id": 559292, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 1 (Disease Ontology:DOID:0070477)", "pathway": " (sce:YIL103W); (R-SCE-5358493)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12940988;14562095;14562106;15485916;17287358;18627462;19795423;19823750;23645155;24374639;24422557;27694803;31463593;34154323;9169870", "class_list": "", "function": "Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323). In association with DPH2, transfers a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:15485916, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVI4", "ec_number_list": "3.6.5.-;2.5.1.108", "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0120513 2-(3-amino-3-carboxypropyl)histidine synthase complex", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P40487-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P41807-1", "uniprot_id": "VATH_YEAST", "mass": 54416.0, "length": 478, "protein_name": "V-type proton ATPase subunit H", "gene_name": "VMA13", "organism": "Yeast", "refseq_name": "H(+)-transporting V1 sector ATPase subunit H", "refseq_ac": "NP_015361", "gene_names_uniprotkb": "VMA13; CLS11; YP3085.02", "gene_names_refseq": "CLS11; VMA13", "protein_names_uniprotkb": "V-type proton ATPase subunit H; V-ATPase 54 kDa subunit; V-ATPase subunit H; Vacuolar proton pump subunit H", "protein_names_refseq": "H(+)-transporting V1 sector ATPase subunit H", "tax_id": 559292, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (sce:YPR036W); (R-SCE-1222556); (R-SCE-77387); (R-SCE-917977); (R-SCE-9639288)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10954728;11416198;14562106;18055462;18407956;19795423;19823750;21126336;22814378;23749301;24374639;25971514;27295975;33481703;33491328;8349704;9169875", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:27295975, PubMed:8349704). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:27295975, PubMed:8349704). This subunit is essential for activity, but not assembly, of the enzyme complex (PubMed:27295975, PubMed:8349704). This subunit is also required for silencing the ATPase activity of V-ATPase when V1 is detached from V0 (PubMed:27295975)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W446", "ec_number_list": "", "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0000329 fungal-type vacuole membrane", "go_biological_process": "GO:0048388 endosomal lumen acidification;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport;GO:0061795 Golgi lumen acidification", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P41807-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P53622-1", "uniprot_id": "COPA_YEAST", "mass": 135607.0, "length": 1201, "protein_name": "Coatomer subunit alpha", "gene_name": "COP1", "organism": "Yeast", "refseq_name": "coatomer subunit alpha", "refseq_ac": "NP_010136", "gene_names_uniprotkb": "COP1; D1578; RET1; SEC33; SOO1", "gene_names_refseq": "COP1; RET1; SEC33; SOO1", "protein_names_uniprotkb": "Coatomer subunit alpha; Alpha-COP; Alpha-coat protein; Retrieval from endoplasmic reticulum protein 1; Secretory protein 22; Suppressor of osmo-sensitivity 1", "protein_names_refseq": "coatomer subunit alpha", "tax_id": 559292, "disease": "autoimmune interstitial lung, joint, and kidney disease (Disease Ontology:DOID:0081242)", "pathway": " (sce:YDL145C); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "14562095;14562106;17101773;18407956;19726565;19779198;21126336;22814378;24374639;33481703;33491328;7724544;8001155;8972581;9169867", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VRK3;Q07595", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0008298 intracellular mRNA localization;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P53622-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40005-1", "uniprot_id": "PFD2_YEAST", "mass": 12994.0, "length": 111, "protein_name": "Prefoldin subunit 2", "gene_name": "GIM4", "organism": "Yeast", "refseq_name": "tubulin-binding prefolding complex subunit GIM4", "refseq_ac": "NP_010913", "gene_names_uniprotkb": "GIM4; PFD2", "gene_names_refseq": "GIM4; PFD2", "protein_names_uniprotkb": "Prefoldin subunit 2; Genes involved in microtubule biogenesis protein 4; Gim complex subunit 4; GimC subunit 4", "protein_names_refseq": "tubulin-binding prefolding complex subunit GIM4", "tax_id": 559292, "disease": "", "pathway": " (sce:YEL003W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "14562095;14562106;17101987;17244705;17322287;24374639;9169868;9463374;9878052", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2TBP1;D3DLP4", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0015631 tubulin binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P40005-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q04969-1", "uniprot_id": "SPC2_YEAST", "mass": 20802.0, "length": 178, "protein_name": "Signal peptidase complex subunit 2", "gene_name": "SPC2", "organism": "Yeast", "refseq_name": "signal peptidase complex subunit SPC2", "refseq_ac": "NP_013657", "gene_names_uniprotkb": "SPC2; SPY1; YM9958.07", "gene_names_refseq": "SPC2; SPY1", "protein_names_uniprotkb": "Signal peptidase complex subunit 2; Microsomal signal peptidase subunit 2", "protein_names_refseq": "signal peptidase complex subunit SPC2", "tax_id": 559292, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (sce:YML055W)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10921929;14562095;14562106;16847258;17322287;24374639;8910564;9148931;9169872", "class_list": "", "function": "Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:10921929, PubMed:8910564). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (PubMed:10921929, PubMed:8910564)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZB9", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing;GO:0120236 negative regulation of post-translational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q04969-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P25443-1", "uniprot_id": "RS2_YEAST", "mass": 27450.0, "length": 254, "protein_name": "Small ribosomal subunit protein uS5", "gene_name": "RPS2", "organism": "Yeast", "refseq_name": "40S ribosomal protein uS5 RPS2", "refseq_ac": "NP_011392", "gene_names_uniprotkb": "RPS2; G2893; RPS4; SUP38; SUP44", "gene_names_refseq": "RPS2; RPS4; SUP138; SUP38; SUP44", "protein_names_uniprotkb": "Small ribosomal subunit protein uS5; 40S ribosomal protein S2; Omnipotent suppressor protein SUP44; RP12; S4; YS5", "protein_names_refseq": "40S ribosomal protein uS5 RPS2", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL123W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-3214858); (R-SCE-6791226); (R-SCE-72649); (R-SCE-72689); (R-SCE-72695); (R-SCE-72702); (R-SCE-72706); (R-SCE-8876725); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954714)", "pathway_count": 14, "publication_count": 31, "publication_id_list": "10601260;11701127;14976550;1544921;15590835;17322287;17545469;18407956;19779198;19823750;20035717;20980660;21109664;22096102;22106047;22218487;2247072;22650761;22814378;23749301;24200810;24374639;24524803;26081071;31062022;32597660;33481703;33491328;8896269;9169869;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). uS5 is important for the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VU25", "ec_number_list": "", "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0006412 translation;GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation;GO:0045903 positive regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P25443-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P26321-1", "uniprot_id": "RL5_YEAST", "mass": 33715.0, "length": 297, "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "RPL5", "organism": "Yeast", "refseq_name": "60S ribosomal protein uL18 RPL5", "refseq_ac": "NP_015194", "gene_names_uniprotkb": "RPL5; LPI14W; RPL1A; RPL1", "gene_names_refseq": "LPI14; RPL1; RPL5", "protein_names_uniprotkb": "Large ribosomal subunit protein uL18; 60S ribosomal protein L5; L1a; L1; Ribosomal 5S RNA-binding protein; YL3", "protein_names_refseq": "60S ribosomal protein uL18 RPL5", "tax_id": 559292, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 6 (Disease Ontology:DOID:0111879); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); glioblastoma (Disease Ontology:DOID:3068); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (sce:YPL131W); (R-SCE-156827); (R-SCE-1799339); (R-SCE-72689); (R-SCE-72706); (R-SCE-975956); (R-SCE-975957); (R-SCE-9954709); (R-SCE-9954714)", "pathway_count": 9, "publication_count": 25, "publication_id_list": "11701127;1325447;14562095;14976550;17287358;17330950;17563356;19779198;2007570;21109664;22096102;22106047;22814378;23118189;23749301;24374639;24524803;32597660;33481703;33491328;37291423;393511;8474444;9169875;9559554", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3N6", "ec_number_list": "", "go_molecular_function": "GO:0008097 5S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P26321-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P46965-1", "uniprot_id": "SPC1_YEAST", "mass": 10819.0, "length": 94, "protein_name": "Signal peptidase complex subunit 1", "gene_name": "SPC1", "organism": "Yeast", "refseq_name": "signal peptidase complex subunit SPC1", "refseq_ac": "NP_012544", "gene_names_uniprotkb": "SPC1; YJR010BW", "gene_names_refseq": "SPC1", "protein_names_uniprotkb": "Signal peptidase complex subunit 1; Microsomal signal peptidase subunit 1", "protein_names_refseq": "signal peptidase complex subunit SPC1", "tax_id": 559292, "disease": "", "pathway": " (sce:YJR010C-A)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10921929;14562106;17322287;22814378;24374639;8641269;8663399;9148931", "class_list": "", "function": "Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:8663399). Dispensable for SPC enzymatic activity (PubMed:8663399)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWI6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46965-1", "record_type": "protein" }, { "uniprot_canonical_ac": "Q02892-1", "uniprot_id": "NOG1_YEAST", "mass": 74410.0, "length": 647, "protein_name": "Nucleolar GTP-binding protein 1", "gene_name": "NOG1", "organism": "Yeast", "refseq_name": "putative GTPase NOG1", "refseq_ac": "NP_015232", "gene_names_uniprotkb": "NOG1; LPG15W", "gene_names_refseq": "NOG1", "protein_names_uniprotkb": "Nucleolar GTP-binding protein 1", "protein_names_refseq": "putative GTPase NOG1", "tax_id": 559292, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (sce:YPL093W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11112701;12808088;14562106;19779198;19795423;19823750;24374639;33481703;33491328;9169875", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3S4", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000054 ribosomal subunit export from nucleus;GO:0006364 rRNA processing;GO:1902626 assembly of large subunit precursor of preribosome", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q02892-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P11986-1", "uniprot_id": "INO1_YEAST", "mass": 59642.0, "length": 533, "protein_name": "Inositol-3-phosphate synthase", "gene_name": "INO1", "organism": "Yeast", "refseq_name": "inositol-3-phosphate synthase INO1", "refseq_ac": "NP_012382", "gene_names_uniprotkb": "INO1; J0610", "gene_names_refseq": "APR1; INO1", "protein_names_uniprotkb": "Inositol-3-phosphate synthase; 5.5.1.4; IPS; MI-1-P synthase; MIP synthase; Myo-inositol 1-phosphate synthase", "protein_names_refseq": "inositol-3-phosphate synthase INO1", "tax_id": 559292, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (sce:YJL153C); (R-SCE-1855183)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11779862;12832758;12836703;14562095;14684747;15576064;19779198;23902760;24374639;2642902;33491328;7975896;8641269;8813765;9294443", "class_list": "", "function": "Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:14684747, PubMed:23902760, Ref.6, Ref.8). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VW34", "ec_number_list": "5.5.1.4", "go_molecular_function": "GO:0004512 inositol-3-phosphate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006021 inositol biosynthetic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P11986-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40106-1", "uniprot_id": "GPP2_YEAST", "mass": 27814.0, "length": 250, "protein_name": "Glycerol-1-phosphate phosphohydrolase 2", "gene_name": "GPP2", "organism": "Yeast", "refseq_name": "glycerol-1-phosphatase GPP2", "refseq_ac": "NP_010984", "gene_names_uniprotkb": "GPP2; HOR2", "gene_names_refseq": "GPP2; HOR2", "protein_names_uniprotkb": "Glycerol-1-phosphate phosphohydrolase 2; (DL)-glycerol-3-phosphatase 2; 3.1.3.21; Hyperosmolarity-responsive protein 2", "protein_names_refseq": "glycerol-1-phosphatase GPP2", "tax_id": 559292, "disease": "", "pathway": " (sce:YER062C)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "14562095;14562106;15665377;17287358;18407956;19779198;20702584;23749301;24374639;33481703;33491328;7500933;8662716;9169868", "class_list": "", "function": "Glycerol-1-phosphate phosphohydrolase involved in glycerol biosynthesis. Plays a role in osmoadaptation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DLW7", "ec_number_list": "3.1.3.21;3.1.3.50", "go_molecular_function": "GO:0046872 metal ion binding;GO:0000121 sn-glycerol 1-phosphatase activity;GO:0043136 sn-glycerol 3-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006970 response to osmotic stress;GO:0005975 carbohydrate metabolic process;GO:0006114 glycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40106-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40107-1", "uniprot_id": "GMT1_YEAST", "mass": 37019.0, "length": 337, "protein_name": "GDP-mannose transporter 1", "gene_name": "VRG4", "organism": "Yeast", "refseq_name": "GDP-mannose transporter", "refseq_ac": "NP_011290", "gene_names_uniprotkb": "VRG4; GOG5; LDB3; MCD3; VAN2; VIG4", "gene_names_refseq": "GOG5; LDB3; VAN2; VIG4; VRG4", "protein_names_uniprotkb": "GDP-mannose transporter 1; GMT 1; Low dye-binding protein 3; Morphogenesis checkpoint-dependent protein 3; Vanadate resistance glycosylation protein 4", "protein_names_refseq": "GDP-mannose transporter", "tax_id": 559292, "disease": "", "pathway": " (sce:YGL225W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10570930;11067855;12478588;14562095;14562106;15494368;16699524;16847258;2014241;2137555;24374639;7672592;7877969;8632002;9169869;9184829;9290212;9335583;9395539", "class_list": "", "function": "Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VVB0", "ec_number_list": "", "go_molecular_function": "GO:0015297 antiporter activity;GO:0005458 GDP-mannose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:1990570 GDP-mannose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40107-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40150-1", "uniprot_id": "SSB2_YEAST", "mass": 66595.0, "length": 613, "protein_name": "Ribosome-associated molecular chaperone SSB2", "gene_name": "SSB2", "organism": "Yeast", "refseq_name": "Hsp70 family ATPase SSB2", "refseq_ac": "NP_014190", "gene_names_uniprotkb": "SSB2; N1333; YG103", "gene_names_refseq": "SSB2; YG103", "protein_names_uniprotkb": "Ribosome-associated molecular chaperone SSB2; 3.6.4.10; Heat shock protein SSB2; Hsp70 chaperone Ssb", "protein_names_refseq": "Hsp70 family ATPase SSB2", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL209W); (R-SCE-3371453); (R-SCE-3371497); (R-SCE-3371568); (R-SCE-3371571); (R-SCE-6798695); (R-SCE-8876725)", "pathway_count": 7, "publication_count": 31, "publication_id_list": "10322015;11739779;11929994;1394434;14562106;15665377;16219770;16221677;17287358;18407956;19779198;19795423;19823750;20702584;21126336;22218487;23332755;23749301;24374639;2651414;27917864;32597660;3302682;33481703;33491328;6761581;7725799;7737086;9169873;9298649;9670014", "class_list": "", "function": "Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone SSE1 and FES1 act as nucleotide exchange factors that cause substrate release., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 38, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Y1", "ec_number_list": "2.7.1.40;5.4.2.11;2.7.1.1;4.2.1.24;3.6.4.13;2.3.1.286;2.4.1.1;5.6.2.3;3.4.23.25;3.6.4.10;5.3.1.9;5.1.3.-;3.6.-.-;5.6.2.4;5.2.1.8;1.11.1.6;3.5.4.6;3.6.4.-;2.7.1.11;5.6.1.4;2.7.1.2;1.1.1.42;3.6.4.12;3.4.25.1;3.6.4.6;5.6.2.5;3.6.5.-;2.7.11.24;3.6.1.-;2.3.2.27;5.4.2.2;1.11.1.24;2.7.4.6;2.4.1.186;1.1.1.205;3.1.-.-;3.4.24.-;2.7.1.35;3.4.19.12;2.4.2.7;5.4.2.7;2.3.2.26;2.7.11.23;2.4.2.1;2.7.1.59;3.5.4.5;3.4.11.-;3.3.2.10;2.7.4.3;2.7.11.1;2.1.1.-;7.2.2.-", "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0051083 'de novo' cotranslational protein folding;GO:0000054 ribosomal subunit export from nucleus;GO:0042149 cellular response to glucose starvation;GO:0006364 rRNA processing;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P40150-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40152-1", "uniprot_id": "PPN2_YEAST", "mass": 37151.0, "length": 326, "protein_name": "Zinc-dependent endopolyphosphatase", "gene_name": "PPN2", "organism": "Yeast", "refseq_name": "putative serine/threonine-protein phosphatase", "refseq_ac": "NP_014182", "gene_names_uniprotkb": "PPN2; N1306", "gene_names_refseq": "PPN2", "protein_names_uniprotkb": "Zinc-dependent endopolyphosphatase; 3.6.1.10; Vacuolar polyphosphatase PPN2", "protein_names_refseq": "putative serine/threonine-protein phosphatase", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL217W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "14562095;17322287;23708375;24374639;28302909;31175919;7762305;9169873", "class_list": "", "function": "Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths. Exclusively shows endopolyphosphatase activity, cleaving inside the polyP chain. Together with PPN1, responsible for a substantial fraction of polyphosphatase activity that is necessary to mobilize polyP stores in response to phosphate scarcity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6W0X3", "ec_number_list": "3.6.1.10;3.6.1.-;3.6.1.11;3.6.1.52;3.6.1.60", "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005775 vacuolar lumen;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006798 polyphosphate catabolic process;GO:0016036 cellular response to phosphate starvation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40152-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40155-1", "uniprot_id": "PEX17_YEAST", "mass": 23169.0, "length": 199, "protein_name": "Peroxisomal membrane protein PEX17", "gene_name": "PEX17", "organism": "Yeast", "refseq_name": "Pex17p", "refseq_ac": "NP_014185", "gene_names_uniprotkb": "PEX17; N1319; PAS9", "gene_names_refseq": "PAS9; PEX17", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX17; Peroxin-17", "protein_names_refseq": "Pex17p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL214W)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14562106;24374639;33323485;7762305;9169873;9425153", "class_list": "", "function": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor or the PEX7-PEX21 or PEX7-PEX18 receptor complex (PubMed:33323485, PubMed:9425153). May play a primarily structural role in the complex (PubMed:33323485)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0X6", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0016560 protein import into peroxisome matrix, docking", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40155-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40167-1", "uniprot_id": "ZC3HD_YEAST", "mass": 34318.0, "length": 298, "protein_name": "Sporulation-specific with a leucine zipper motif protein 1", "gene_name": "SLZ1", "organism": "Yeast", "refseq_name": "Slz1p", "refseq_ac": "NP_014203", "gene_names_uniprotkb": "SLZ1; N1386", "gene_names_refseq": "SLZ1", "protein_names_uniprotkb": "Sporulation-specific with a leucine zipper motif protein 1", "protein_names_refseq": "Slz1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YNL196C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11921089;22685417;24269006;24374639;36930734;7725799;9169873", "class_list": "", "function": "Component of the MIS complex, a complex that mediates N6-methyladenosine (m6A) methylation of meiotic mRNAs and is required for initiation of meiosis, progression through the meiotic divisions and sporulation (PubMed:22685417, PubMed:24269006, PubMed:36930734). In the complex, mediates the entry of the MIS complex in nucleolus, where methylation takes place (PubMed:24269006)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0Z1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051321 meiotic cell cycle;GO:0030435 sporulation resulting in formation of a cellular spore;GO:2000221 negative regulation of pseudohyphal growth", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40167-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40204-1", "uniprot_id": "RUXG_YEAST", "mass": 8482.0, "length": 77, "protein_name": "Small nuclear ribonucleoprotein G", "gene_name": "SMX2", "organism": "Yeast", "refseq_name": "mRNA splicing protein SMX2", "refseq_ac": "NP_116636", "gene_names_uniprotkb": "SMX2; SNP2; YFL017Bw", "gene_names_refseq": "SMX2; SNP2; YFL018W-A", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein G; Sm protein G; Sm-G; SmG; snRNP-G", "protein_names_refseq": "mRNA splicing protein SMX2", "tax_id": 559292, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (sce:YFL017W-A)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10369684;10449419;11302706;11804584;11884590;14562106;17322287;24374639;3058861;33491328;7670463;9012791;9528767", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VTL2", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40204-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40208-1", "uniprot_id": "GID8_YEAST", "mass": 51729.0, "length": 455, "protein_name": "GID complex subunit 8", "gene_name": "GID8", "organism": "Yeast", "refseq_name": "glucose-induced degradation complex subunit GID8", "refseq_ac": "NP_013854", "gene_names_uniprotkb": "GID8; DCR1; YM9375.04C", "gene_names_refseq": "DCR1; GID8", "protein_names_uniprotkb": "GID complex subunit 8; Dosage-dependent cell cycle regulator 1; Glucose-induced degradation protein 8", "protein_names_refseq": "glucose-induced degradation complex subunit GID8", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR135C)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "12686616;14562095;14562106;15590836;16872538;18508925;19779198;22645139;23749301;24374639;31708416;33481703;33491328;33905682;35650207;9169872", "class_list": "", "function": "Component of the GID E3 ligase complex recruiting N termini and catalyzing ubiquitination of proteins targeted for degradation. GID E3 is regulated through assembly with interchangeable N-degron-binding substrate receptors induced by distinct environmental perturbations (PubMed:12686616, PubMed:31708416). Required for the adaptation to the presence of glucose in the growth medium; mediates in association with the substrate receptor VID24/GID4 the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:12686616, PubMed:31708416). Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1), malate dehydrogenase (MDH2), and other gluconeogenic enzymes (PubMed:12686616, PubMed:22645139). Required also for cell cycle progression. Positively controls G1 and the timing of START (PubMed:15590836)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZV8", "ec_number_list": "", "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex;GO:0034657 GID complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045721 negative regulation of gluconeogenesis;GO:0007089 traversing start control point of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40208-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40215-1", "uniprot_id": "NDH1_YEAST", "mass": 62774.0, "length": 560, "protein_name": "External NADH-ubiquinone oxidoreductase 1, mitochondrial", "gene_name": "NDE1", "organism": "Yeast", "refseq_name": "NADH-ubiquinone reductase (H(+)-translocating) NDE1", "refseq_ac": "NP_013865", "gene_names_uniprotkb": "NDE1; NDH1; YM9375.14C", "gene_names_refseq": "NDE1; NDH1", "protein_names_uniprotkb": "External NADH-ubiquinone oxidoreductase 1, mitochondrial; 1.6.5.9; External NADH dehydrogenase 1", "protein_names_refseq": "NADH-ubiquinone reductase (H(+)-translocating) NDE1", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR145C)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10781551;11502169;11713283;12032156;14562106;14576278;17322287;24374639;33481703;33491328;9169872;9696750;9733747", "class_list": "", "function": "External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxidation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D6VZW7", "ec_number_list": "1.6.5.9", "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0016491 oxidoreductase activity;GO:0120555 NADH dehydrogenase (ubiquinone) (non-electrogenic) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0019655 glycolytic fermentation to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P40215-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40308-1", "uniprot_id": "TGL3_YEAST", "mass": 73613.0, "length": 642, "protein_name": "Triacylglycerol lipase 3", "gene_name": "TGL3", "organism": "Yeast", "refseq_name": "bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase", "refseq_ac": "NP_014044", "gene_names_uniprotkb": "TGL3; YM9924.05C", "gene_names_refseq": "TGL3", "protein_names_uniprotkb": "Triacylglycerol lipase 3; 3.1.1.3; Lipase 3", "protein_names_refseq": "bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YMR313C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10515935;12682047;14562106;16267052;18407956;19779198;19795423;19823750;20016004;21126336;21820081;23673660;23749301;24374639;24868093;32597660;33491328;7918444;9169872", "class_list": "", "function": "Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate metabolic pathways (PubMed:10515935, PubMed:12682047, PubMed:16267052). Also catalyzes the acylation of lysophosphatidic acid (LPA). Important for efficient sporulation, but rather through its acyltransferase than lipase activity (PubMed:20016004)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W0E0", "ec_number_list": "3.1.1.3;1.1.1.101", "go_molecular_function": "GO:0004806 triacylglycerol lipase activity;GO:0071618 lysophosphatidylethanolamine acyltransferase activity", "go_cellular_component": "GO:0005811 lipid droplet", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0019433 triglyceride catabolic process;GO:0007114 cell budding", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40308-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40316-1", "uniprot_id": "SECU_YEAST", "mass": 41838.0, "length": 373, "protein_name": "Securin", "gene_name": "PDS1", "organism": "Yeast", "refseq_name": "securin", "refseq_ac": "NP_010398", "gene_names_uniprotkb": "PDS1; YD9727.08C", "gene_names_refseq": "PDS1", "protein_names_uniprotkb": "Securin", "protein_names_refseq": "securin", "tax_id": 559292, "disease": "", "pathway": " (sce:YDR113C)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "11390356;11553328;12050115;17287358;17322287;17563356;18407956;19520826;19684113;19779198;20421994;21126336;21177495;23749301;24374639;32597660;33481703;33491328;8601617;8985178;9169867;9635435", "class_list": "", "function": "Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESP1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESP1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VS98", "ec_number_list": "", "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0051301 cell division;GO:0006974 DNA damage response;GO:0008104 intracellular protein localization;GO:0000725 recombinational repair;GO:0001100 negative regulation of exit from mitosis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P40316-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40319-1", "uniprot_id": "ELO3_YEAST", "mass": 39465.0, "length": 345, "protein_name": "Fatty acid elongase 3", "gene_name": "ELO3", "organism": "Yeast", "refseq_name": "fatty acid elongase ELO3", "refseq_ac": "NP_013476", "gene_names_uniprotkb": "ELO3; APA1; L8039.2; SRE1; SUR4; VBM1", "gene_names_refseq": "APA1; ELO3; SRE1; SUR4; VBM1", "protein_names_uniprotkb": "Fatty acid elongase 3; 2.3.1.199; 3-keto acyl-CoA synthase ELO3; Affecting plasma membrane ATPase activity protein 1; Elongation of fatty acids protein 3; Suppressor of RAD3 essential function protein 1; Suppressor of Rvs161 and Rvs167 mutations protein 4; Very-long-chain 3-oxoacyl-CoA synthase 3; v-SNARE bypass mutant gene 1 protein", "protein_names_refseq": "fatty acid elongase ELO3", "tax_id": 559292, "disease": "spinocerebellar ataxia 34 (Disease Ontology:DOID:0050981); spinocerebellar ataxia 38 (Disease Ontology:DOID:0050985); adrenoleukodystrophy (Disease Ontology:DOID:10588); corneal dystrophy (Disease Ontology:DOID:2566); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (sce:YLR372W)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "12087109;12684876;14562095;16847258;17719544;18407956;23749301;24374639;29458843;32597660;3323825;33481703;33491328;8027068;8488727;8649379;9169871;9211877;9832547", "class_list": "", "function": "Component of a microsomal membrane bound long-chain fatty acid elongation system, which produces the 20-26-carbon very long-chain fatty acids (VLCFA) from long-chain fatty acid precursors and is involved ceramide and inositol sphingolipid biosynthesis. Component of elongase III, which synthesizes 20-26-carbon fatty acids from 18-carbon-fatty acyl-CoA primers such as stearoyl-CoA by incorporation of malonyl-CoA (PubMed:12684876, PubMed:9211877). The enzymes active site faces the cytosol, whereas VLCFA length is determined by a lysine near the luminal end of transmembrane helix 6 (PubMed:17719544). Plays an important role in lipotoxic cell death induced by oleic acid through maintaining a balanced fatty acid composition in thr plasma membrane (PubMed:29458843). Affects plasma membrane H(+)-ATPase activity. May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3 (PubMed:8027068)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VZ09", "ec_number_list": "2.3.1.199", "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006892 post-Golgi vesicle-mediated transport;GO:0030497 fatty acid elongation;GO:0034625 fatty acid elongation, monounsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40319-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40335-1", "uniprot_id": "PEP8_YEAST", "mass": 42547.0, "length": 379, "protein_name": "Carboxypeptidase Y-deficient protein 8", "gene_name": "PEP8", "organism": "Yeast", "refseq_name": "retromer subunit PEP8", "refseq_ac": "NP_012482", "gene_names_uniprotkb": "PEP8; GRD6; J1152; VPS26; VPT4", "gene_names_refseq": "GRD6; PEP8; VPS26; VPT4", "protein_names_uniprotkb": "Carboxypeptidase Y-deficient protein 8; Vacuolar protein sorting-associated protein 26; Vacuolar protein-targeting protein 4", "protein_names_refseq": "retromer subunit PEP8", "tax_id": 559292, "disease": "brain cancer (Disease Ontology:DOID:1319); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (sce:YJL053W); (R-SCE-3238698)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "17322287;19779198;19795423;19823750;21126336;21177495;23749301;24374639;32597660;33481703;33491328;7926738;8641269;9700157", "class_list": "", "function": "Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWC9;E9P910", "ec_number_list": "", "go_molecular_function": "GO:0140318 protein transporter activity", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0012505 endomembrane system", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P40335-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40340-1", "uniprot_id": "ATAD2_YEAST", "mass": 157407.0, "length": 1379, "protein_name": "ATPase histone chaperone YTA7", "gene_name": "YTA7", "organism": "Yeast", "refseq_name": "chromatin segregase YTA7", "refseq_ac": "NP_011786", "gene_names_uniprotkb": "YTA7", "gene_names_refseq": "YTA7", "protein_names_uniprotkb": "ATPase histone chaperone YTA7; 3.6.1.-; AAA-ATPase; ATPase family AAA domain-containing protein YTA7; Tat-binding homolog 7", "protein_names_refseq": "chromatin segregase YTA7", "tax_id": 559292, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (sce:YGR270W)", "pathway_count": 1, "publication_count": 29, "publication_id_list": "14562106;15972895;16079223;17287358;17330950;17563356;18407956;19683497;19684113;19779198;19795423;19823750;20190278;20489023;20702584;21126336;21177495;22156209;23749301;24374639;25406467;32079723;32597660;33481703;33491328;34471130;7754704;9169869;9605509", "class_list": "", "function": "Functions as an ATP-dependent nucleosome disassembly factor that helps evict canonical histone H3 from the 5'-end of genes upon their induction (PubMed:25406467). Also contributes to kinetochore assembly by cooperating with SCM3 to load the histone H3 variant CSE4/CENP-A at centromeres (PubMed:32079723). Provides a chromatin boundary function at the 5'-end of genes that restricts access by RTT106 and thus prevents ectopic spreading of repressive chromatin into coding regions (PubMed:19683497, PubMed:22156209, PubMed:25406467). Also prevents heterochromatin spreading downstream of the silent mating-type locus HMR, this function is independent of the tRNA boundary element (PubMed:16079223). Contributes to appropriate cell cycle regulation of histone gene expression by recruiting RNA polymerase II to histone genes, and subsequent CDK1- and casein kinase II-dependent eviction from chromatin is required to promote transcriptional elongation (PubMed:22156209)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 41, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VV47", "ec_number_list": "", "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding;GO:0140674 ATP-dependent histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P40340-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40341-1", "uniprot_id": "YTA12_YEAST", "mass": 93276.0, "length": 825, "protein_name": "Mitochondrial inner membrane m-AAA protease component YTA12", "gene_name": "YTA12", "organism": "Yeast", "refseq_name": "m-AAA protease subunit YTA12", "refseq_ac": "NP_013807", "gene_names_uniprotkb": "YTA12; RCA1; YM9582.14C", "gene_names_refseq": "RCA1; YTA12", "protein_names_uniprotkb": "Mitochondrial inner membrane m-AAA protease component YTA12; 3.4.24.-; 3.6.-.-; Tat-binding homolog 12", "protein_names_refseq": "m-AAA protease subunit YTA12", "tax_id": 559292, "disease": "spastic ataxia 5 (Disease Ontology:DOID:0050944); spastic ataxia (Disease Ontology:DOID:0050952); spinocerebellar ataxia 28 (Disease Ontology:DOID:0050977); optic atrophy 12 (Disease Ontology:DOID:0080840); neurodegenerative disease (Disease Ontology:DOID:1289); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (sce:YMR089C); (R-SCE-9837999)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10207067;12417197;14562106;16239145;17245427;17322287;19748354;21610694;23283966;24374639;29030426;7754704;7929327;8681382;9169872;9707443", "class_list": "", "function": "Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins (PubMed:17245427, PubMed:19748354, PubMed:21610694, PubMed:8681382). YTA12/RCA1 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments (PubMed:19748354). The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes (PubMed:9707443). The m-AAA protease carries out protein quality control in the inner membrane of the mitochondria by mediating degradation of mistranslated or misfolded polypeptides (PubMed:8681382). It also mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome (PubMed:16239145, PubMed:21610694). Promotes maturation of cytochrome c peroxidase (CCP1) by acting as a membrane protein dislocase via its ATPase activity: pulls the CCP1 transmembrane to the matrix prior to processing by the rhomboid protease PCP1 (PubMed:17245427). The membrane protein dislocase activity is also required to dislocate moderately hydrophobic transmembrane segments from the membrane (PubMed:23283966, PubMed:29030426)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VZR2;E9P917", "ec_number_list": "7.1.1.9;3.6.4.13;5.6.2.3;3.6.4.10;3.6.-.-;5.6.2.4;3.6.4.-;5.6.1.4;3.6.4.12;3.6.4.6;5.6.2.5;3.6.1.-;2.3.2.27;3.1.-.-;3.4.24.-;3.6.5.-;2.7.4.3;2.7.11.1;7.2.2.-", "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005745 m-AAA complex;GO:0097002 mitochondrial inner boundary membrane", "go_biological_process": "GO:0030163 protein catabolic process;GO:0034982 mitochondrial protein processing;GO:0051604 protein maturation;GO:0006465 signal peptide processing;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40341-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40345-1", "uniprot_id": "PDAT_YEAST", "mass": 75393.0, "length": 661, "protein_name": "Phospholipid:diacylglycerol acyltransferase", "gene_name": "LRO1", "organism": "Yeast", "refseq_name": "phospholipid:diacylglycerol acyltransferase", "refseq_ac": "NP_014405", "gene_names_uniprotkb": "LRO1; N2042", "gene_names_refseq": "LRO1", "protein_names_uniprotkb": "Phospholipid:diacylglycerol acyltransferase; 2.3.1.158; LCAT-related open reading frame 1; Lecithin cholesterol acyl transferase-related open reading frame 1; PDAT; TAG synthase; Triacylglycerol synthase", "protein_names_refseq": "phospholipid:diacylglycerol acyltransferase", "tax_id": 559292, "disease": "familial hyperlipidemia (Disease Ontology:DOID:1168); Norum disease (Disease Ontology:DOID:1391); arteriosclerosis (Disease Ontology:DOID:2349); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (sce:YNR008W)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10747858;10829075;18037386;22446555;22454508;22738231;24374639;30706417;31422915;32349126;32597660;33491328;7900425;9169873", "class_list": "", "function": "Catalyzes triacylglycerol (TAG) formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol (DAG), thus forming an sn-1-lysophospholipid (PubMed:10747858, PubMed:10829075, PubMed:32349126). The preferred acyl donors are phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Also capable of using broad acyl donors such as phosphatidic acid (PA), phosphatidylserine (PS), phosphatidylglycerol (PG) and phosphatidylinositol (PI), as well as monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG), and acyl-CoA, and it is more likely to use unsaturated acyl donors. As acyl acceptors, it prefers 1,2- over 1,3-diacylglycerol (DAG). Additionally, has esterification activity that can utilize methanol as acyl acceptor to generate fatty acid methyl esters (FAME) (PubMed:30706417). Can also utilize ceramide instead of DAG, acylating the ceramides by attaching a fatty acid to the hydroxy group on the first carbon atom of the long-chain base to produce 1-O-acylceramides (PubMed:22738231). Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains (PubMed:32349126). Relocates from the endoplasmic reticulum to a subdomain of the inner nuclear membrane upon nutrient starvation, where it provides a site of TAG synthesis, which is coupled with nuclear membrane remodeling (PubMed:31422915)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6W1I3", "ec_number_list": "2.3.1.158", "go_molecular_function": "GO:0008374 O-acyltransferase activity;GO:0046027 phospholipid:diacylglycerol acyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006672 ceramide metabolic process;GO:0055091 phospholipid homeostasis;GO:0019915 lipid storage;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P40345-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40347-1", "uniprot_id": "PPAL_YEAST", "mass": 18675.0, "length": 161, "protein_name": "Low molecular weight phosphotyrosine protein phosphatase", "gene_name": "LTP1", "organism": "Yeast", "refseq_name": "tyrosine protein phosphatase LTP1", "refseq_ac": "NP_015398", "gene_names_uniprotkb": "LTP1; YP9499.28C", "gene_names_refseq": "LTP1", "protein_names_uniprotkb": "Low molecular weight phosphotyrosine protein phosphatase; 3.1.3.2; 3.1.3.48; Low molecular weight cytosolic acid phosphatase; PTPase", "protein_names_refseq": "tyrosine protein phosphatase LTP1", "tax_id": 559292, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); conduct disorder (Disease Ontology:DOID:12995); coronary artery disease (Disease Ontology:DOID:3393); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YPR073C)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10684601;10684639;14562106;17322287;18407956;24374639;32597660;33481703;33491328;7629177;9169875", "class_list": "", "function": "Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W477", "ec_number_list": "3.1.3.2;3.1.3.1;3.1.3.54;3.1.7.6;3.1.3.48;3.1.3.16", "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P40347-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40350-1", "uniprot_id": "ALG5_YEAST", "mass": 38347.0, "length": 334, "protein_name": "Dolichyl-phosphate beta-glucosyltransferase", "gene_name": "ALG5", "organism": "Yeast", "refseq_name": "dolichyl-phosphate beta-glucosyltransferase", "refseq_ac": "NP_015097", "gene_names_uniprotkb": "ALG5; P1437", "gene_names_refseq": "ALG5", "protein_names_uniprotkb": "Dolichyl-phosphate beta-glucosyltransferase; 2.4.1.117; Asparagine-linked glycosylation protein 5; DolP-glucosyltransferase", "protein_names_refseq": "dolichyl-phosphate beta-glucosyltransferase", "tax_id": 559292, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); polycystic kidney disease 7 (Disease Ontology:DOID:0060952)", "pathway": " (sce:YPL227C); (R-SCE-480985)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14562106;24374639;33491328;8076653;9169875", "class_list": "", "function": "Endoplasmic reticulum membrane-bound UDP-glucose:dolichyl-phosphate glucosyltransferase involved in protein N-linked glycosylation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W3E3", "ec_number_list": "2.4.1.117", "go_molecular_function": "GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40350-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40353-1", "uniprot_id": "ATF1_YEAST", "mass": 61036.0, "length": 525, "protein_name": "Alcohol O-acetyltransferase 1", "gene_name": "ATF1", "organism": "Yeast", "refseq_name": "alcohol O-acetyltransferase", "refseq_ac": "NP_015022", "gene_names_uniprotkb": "ATF1", "gene_names_refseq": "ATF1", "protein_names_uniprotkb": "Alcohol O-acetyltransferase 1; 2.3.1.84; 3.1.2.20; AATase 1", "protein_names_refseq": "alcohol O-acetyltransferase", "tax_id": 559292, "disease": "", "pathway": " (sce:YOR377W)", "pathway_count": 1, "publication_count": 28, "publication_id_list": "10487921;10653746;12937998;12957907;14562106;14654433;15042596;16845703;17891501;18597084;24374639;24609358;25093817;25281839;25306884;25310977;25447641;26205521;26801935;28160314;28176138;28497697;7764365;8085822;9055409;9169874;9675816;9758847", "class_list": "", "function": "Major alcohol O-acetyltransferase that uses acetyl-CoA to synthesize acetate esters from various alcohols, producing ethyl acetate, isoamyl acetate, isobutyl acetate, butyl acetate, hexyl acetate, heptyl acetate and octyl acetate (PubMed:10653746, PubMed:12937998, PubMed:16845703, PubMed:17891501, PubMed:18597084, PubMed:25306884, PubMed:28160314, PubMed:7764365, PubMed:9758847). The alcohol acyltransferase activity is promiscuous with regard to alcohol but relatively specific for acetyl-CoA since ATF1 does not use any other acyl-CoAs (C3, C4, C5, C6, C8, C10, C12) (PubMed:28160314). Acts also as an efficient thioesterase in vitro with specificity towards medium-chain-length acyl-CoAs (PubMed:28160314). In natural environments, the production of aromatic volatile metabolites promotes dispersal through insect vectors (PubMed:25310977)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W370;Q08901", "ec_number_list": "3.1.1.-;2.3.1.84;3.1.2.20", "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0008080 N-acetyltransferase activity;GO:0004026 alcohol O-acetyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1901089 acetate ester metabolic process involved in fermentation", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P40353-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40358-1", "uniprot_id": "JEM1_YEAST", "mass": 75144.0, "length": 645, "protein_name": "DnaJ-like chaperone JEM1", "gene_name": "JEM1", "organism": "Yeast", "refseq_name": "Jem1p", "refseq_ac": "NP_012462", "gene_names_uniprotkb": "JEM1; HRC558; J1083; KAR8", "gene_names_refseq": "JEM1; KAR8", "protein_names_uniprotkb": "DnaJ-like chaperone JEM1; DnaJ-like protein of the ER membrane 1", "protein_names_refseq": "Jem1p", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL073W); (R-SCE-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12493774;14562106;15282802;24374639;7762302;8641269;9148890", "class_list": "", "function": "Acts as a DnaJ-like chaperone required for nuclear membrane fusion during mating., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWB0", "ec_number_list": "", "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network", "go_biological_process": "GO:0036503 ERAD pathway;GO:0034975 protein folding in endoplasmic reticulum;GO:0000742 karyogamy involved in conjugation with cellular fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40358-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40359-1", "uniprot_id": "PSF2_YEAST", "mass": 25061.0, "length": 213, "protein_name": "DNA replication complex GINS protein PSF2", "gene_name": "PSF2", "organism": "Yeast", "refseq_name": "DNA replication protein PSF2", "refseq_ac": "NP_012463", "gene_names_uniprotkb": "PSF2; HRF213; J1086", "gene_names_refseq": "CDC102; PSF2", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF2; Partner of Sld five 2", "protein_names_refseq": "DNA replication protein PSF2", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL072C); (R-SCE-176974)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12730134;14690591;17322287;24374639;7762302;8641269", "class_list": "", "function": "Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VWB1", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0031261 DNA replication preinitiation complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000727 double-strand break repair via break-induced replication;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P40359-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40360-1", "uniprot_id": "NAGS_YEAST", "mass": 65610.0, "length": 574, "protein_name": "Amino-acid acetyltransferase, mitochondrial", "gene_name": "ARG2", "organism": "Yeast", "refseq_name": "acetyl-CoA:L-glutamate N-acetyltransferase", "refseq_ac": "NP_012464", "gene_names_uniprotkb": "ARG2; HRB574; J1091", "gene_names_refseq": "ARG2; HRB574", "protein_names_uniprotkb": "Amino-acid acetyltransferase, mitochondrial; 2.3.1.1; AGS; Arginine-requiring protein 2; Glutamate N-acetyltransferase; N-acetylglutamate synthase; NAGS", "protein_names_refseq": "acetyl-CoA:L-glutamate N-acetyltransferase", "tax_id": 559292, "disease": "N-acetylglutamate synthase deficiency (Disease Ontology:DOID:0112258); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YJL071W)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11553611;14562095;14562106;19795423;19823750;205532;24374639;33229814;391804;7762302;8641269", "class_list": "", "function": "N-acetylglutamate synthase involved in arginine biosynthesis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VWB2", "ec_number_list": "2.3.1.1;2.3.1.35", "go_molecular_function": "GO:0004042 L-glutamate N-acetyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006526 L-arginine biosynthetic process;GO:0006592 ornithine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40360-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40367-1", "uniprot_id": "GPI7_YEAST", "mass": 94851.0, "length": 830, "protein_name": "GPI ethanolamine phosphate transferase 2", "gene_name": "LAS21", "organism": "Yeast", "refseq_name": "mannose-ethanolamine phosphotransferase LAS21", "refseq_ac": "NP_012473", "gene_names_uniprotkb": "LAS21; GPI7; HRC830; J1132", "gene_names_refseq": "GPI7; LAS21", "protein_names_uniprotkb": "GPI ethanolamine phosphate transferase 2; 2.-.-.-; Glycosylphosphatidylinositol-anchor biosynthesis protein 7; Local anestheticum-sensitive protein 21", "protein_names_refseq": "mannose-ethanolamine phosphotransferase LAS21", "tax_id": 559292, "disease": "", "pathway": " (sce:YJL062W); (R-SCE-162710)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10329735;10734606;14562095;14562106;14985347;15452134;16847258;24374639;7762302;8641269", "class_list": "", "function": "Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose. Although not essential, addition of ethanolamine phosphate to the second mannose plays an important role in cell separation via the GPI-based modification of daughter-specific proteins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "D6VWC0", "ec_number_list": "2.-.-.-", "go_molecular_function": "GO:0051267 CP2 mannose-ethanolamine phosphotransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40367-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40414-1", "uniprot_id": "TPM2_YEAST", "mass": 19093.0, "length": 161, "protein_name": "Tropomyosin-2", "gene_name": "TPM2", "organism": "Yeast", "refseq_name": "tropomyosin TPM2", "refseq_ac": "NP_012128", "gene_names_uniprotkb": "TPM2", "gene_names_refseq": "TPM2", "protein_names_uniprotkb": "Tropomyosin-2", "protein_names_refseq": "tropomyosin TPM2", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL138C); (R-SCE-9013424)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "14562106;15665377;17322287;17563356;18407956;19779198;19795423;19823750;21126336;21177495;24374639;30516470;33481703;33491328;7844152;9169870", "class_list": "", "function": "Involved in cell morphogenesis. Binds to F-actin and stabilizes the actin filaments., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVE8", "ec_number_list": "", "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0003786 actin lateral binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005826 actomyosin contractile ring;GO:0032432 actin filament bundle;GO:0000142 cellular bud neck contractile ring", "go_biological_process": "GO:0007015 actin filament organization;GO:0051017 actin filament bundle assembly;GO:0000281 mitotic cytokinesis;GO:1903475 mitotic actomyosin contractile ring assembly;GO:0000282 cellular bud site selection", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40414-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40422-1", "uniprot_id": "RPAB4_YEAST", "mass": 7716.0, "length": 70, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC4", "gene_name": "RPC10", "organism": "Yeast", "refseq_name": "DNA-directed RNA polymerase core subunit RPC10", "refseq_ac": "NP_012013", "gene_names_uniprotkb": "RPC10; RPB12; YHR143BW", "gene_names_refseq": "RPB12; RPC10", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC4; ABC10-alpha; RNA polymerases I, II, and III subunit ABC4", "protein_names_refseq": "DNA-directed RNA polymerase core subunit RPC10", "tax_id": 559292, "disease": "", "pathway": " (sce:YHR143W-A); (R-SCE-113418); (R-SCE-674695); (R-SCE-6781823); (R-SCE-6782135); (R-SCE-6782210); (R-SCE-6796648); (R-SCE-6807505); (R-SCE-72086); (R-SCE-72203); (R-SCE-73762); (R-SCE-73772); (R-SCE-73776); (R-SCE-73779); (R-SCE-75953); (R-SCE-76042); (R-SCE-76061); (R-SCE-76066); (R-SCE-77075); (R-SCE-9018519)", "pathway_count": 20, "publication_count": 33, "publication_id_list": "10384303;10559229;11313498;11313499;11805306;12746495;12746498;12914699;14562095;14562106;14580350;14963322;15537538;15591044;15610738;1617300;16341226;16765890;16818233;17322287;18160037;18407956;21126336;23749301;24153182;24153184;24374639;30181345;32597660;33481703;33491328;35563734;8091229", "class_list": "", "function": "DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3DL93", "ec_number_list": "", "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0042254 ribosome biogenesis;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P40422-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40438-1", "uniprot_id": "VTH1_YEAST", "mass": 174428.0, "length": 1549, "protein_name": "VPS10 homolog 1", "gene_name": "VTH1", "organism": "Yeast", "refseq_name": "signal sequence-binding protein", "refseq_ac": "NP_012095", "gene_names_uniprotkb": "VTH1", "gene_names_refseq": "VTH1", "protein_names_uniprotkb": "VPS10 homolog 1; Sortilin VTH1", "protein_names_refseq": "signal sequence-binding protein", "tax_id": 559292, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); proteinuria (Disease Ontology:DOID:576); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (sce:YIL173W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562095;14562106;19684113;23749301;24374639;33481703;33491328;8636229;8662642;9169870", "class_list": "", "function": "Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "D6VVB8", "ec_number_list": "", "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0000166 nucleotide binding;GO:0005048 signal sequence binding", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006895 Golgi to endosome transport;GO:0006623 protein targeting to vacuole;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40438-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40462-1", "uniprot_id": "TM108_YEAST", "mass": 107723.0, "length": 946, "protein_name": "Protein TMA108", "gene_name": "TMA108", "organism": "Yeast", "refseq_name": "Tma108p", "refseq_ac": "NP_012129", "gene_names_uniprotkb": "TMA108", "gene_names_refseq": "TAE3; TMA108", "protein_names_uniprotkb": "Protein TMA108; 108 kDa translation machinery-associated protein; 3.4.11.-", "protein_names_refseq": "Tma108p", "tax_id": 559292, "disease": "severe pre-eclampsia (Disease Ontology:DOID:13129); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (sce:YIL137C); (R-SCE-6798695); (R-SCE-983168); (R-SCE-983170)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "14562095;14562106;16702403;19795423;19823750;21126336;22814378;24374639;33491328;9169870", "class_list": "", "function": "Putative zinc aminopeptidase which may be involved in ribosome biogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVE9", "ec_number_list": "3.6.5.2;3.1.3.48;3.4.11.-;3.4.22.40;1.2.1.3;1.2.1.64", "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:1990593 nascent polypeptide-associated complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005854 nascent polypeptide-associated complex", "go_biological_process": "GO:2000765 regulation of cytoplasmic translation;GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40462-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40465-1", "uniprot_id": "CSM2_YEAST", "mass": 24953.0, "length": 213, "protein_name": "Chromosome segregation in meiosis protein 2", "gene_name": "CSM2", "organism": "Yeast", "refseq_name": "Csm2p", "refseq_ac": "NP_012134", "gene_names_uniprotkb": "CSM2", "gene_names_refseq": "CSM2", "protein_names_uniprotkb": "Chromosome segregation in meiosis protein 2", "protein_names_refseq": "Csm2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL132C)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11470404;12972632;14562095;14562106;15184655;15654096;16273108;19496932;24374639;9169870", "class_list": "", "function": "Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVF5;Q45U15", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035861 site of double-strand break;GO:0097196 Shu complex", "go_biological_process": "GO:0045132 meiotic chromosome segregation;GO:0000725 recombinational repair;GO:0000730 DNA recombinase assembly;GO:0042275 error-free postreplication DNA repair;GO:0043007 maintenance of rDNA", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40465-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40466-1", "uniprot_id": "FKH1_YEAST", "mass": 53490.0, "length": 484, "protein_name": "Fork head protein homolog 1", "gene_name": "FKH1", "organism": "Yeast", "refseq_name": "forkhead family transcription factor FKH1", "refseq_ac": "NP_012135", "gene_names_uniprotkb": "FKH1", "gene_names_refseq": "FKH1", "protein_names_uniprotkb": "Fork head protein homolog 1", "protein_names_refseq": "forkhead family transcription factor FKH1", "tax_id": 559292, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); Bamforth-Lazarus syndrome (Disease Ontology:DOID:0050655); brain glioma (Disease Ontology:DOID:0060108); ptosis (Disease Ontology:DOID:0060260); anterior segment dysgenesis (Disease Ontology:DOID:0060648); Pendred Syndrome (Disease Ontology:DOID:0060744); otosclerosis 11 (Disease Ontology:DOID:0060928); anterior segment dysgenesis 2 (Disease Ontology:DOID:0080607); anterior segment dysgenesis 3 (Disease Ontology:DOID:0080608); Axenfeld-Rieger syndrome type 3 (Disease Ontology:DOID:0110122); cataract 34 multiple types (Disease Ontology:DOID:0110230); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498); lymphedema-distichiasis syndrome (Disease Ontology:DOID:0111509); stomach cancer (Disease Ontology:DOID:10534); nephritis (Disease Ontology:DOID:10952); buphthalmos (Disease Ontology:DOID:11211); congenital aphakia (Disease Ontology:DOID:11367); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185); vitiligo (Disease Ontology:DOID:12306); lung cancer (Disease Ontology:DOID:1324); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); colon carcinoma (Disease Ontology:DOID:1520); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); colon adenocarcinoma (Disease Ontology:DOID:234); Goldenhar syndrome (Disease Ontology:DOID:2907); invasive ductal carcinoma (Disease Ontology:DOID:3008); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); esophagus adenocarcinoma (Disease Ontology:DOID:4914); lymphedema (Disease Ontology:DOID:4977); eyelid disease (Disease Ontology:DOID:530); lung small cell carcinoma (Disease Ontology:DOID:5409); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (sce:YIL131C); (R-SCE-3232118); (R-SCE-9018519)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10747051;10894548;10894549;10959837;11562353;12183363;12702877;14562106;16273108;16809780;17283050;22265405;22438832;22496671;22932476;24374639;24504085;26728715;27257873;33491328;9169870", "class_list": "", "function": "Transcription factor that regulates the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle (PubMed:10894548, PubMed:10894549, PubMed:10959837, PubMed:11562353, PubMed:12702877, PubMed:17283050, PubMed:24504085). The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20 as well as SWI5 and ACE2, transcription factors required for the subsequent temporal wave of cell cycle regulated gene expression in the M/G1 phase interval (PubMed:10894548, PubMed:10959837, PubMed:11562353). Involved in HMRa silencing (PubMed:10747051). FKH1 and FKH2 associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing (PubMed:12702877). Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation (PubMed:22438832). FKH1 and FKH2 function also in controlling yeast cell morphology by preventing preudohyphal growth (PubMed:10747051, PubMed:10894548). Acts as a rate-limiting replication origin activator via its interaction with the origin recognition complex (ORC) (PubMed:22265405, PubMed:26728715). Plays a transcription-independent role in recombination donor preference during mating-type switching through binding to the recombination enhancer (RE), a 700-bp cis-acting element that controls recombination along the left arm of chromosome III (PubMed:12183363, PubMed:16809780, PubMed:22496671, PubMed:27257873)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVF6;Q45U14", "ec_number_list": "", "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P40466-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40469-1", "uniprot_id": "MET18_YEAST", "mass": 117883.0, "length": 1032, "protein_name": "DNA repair/transcription protein MET18/MMS19", "gene_name": "MET18", "organism": "Yeast", "refseq_name": "Met18p", "refseq_ac": "NP_012138", "gene_names_uniprotkb": "MET18; MMS19", "gene_names_refseq": "MET18; MMS19", "protein_names_uniprotkb": "DNA repair/transcription protein MET18/MMS19; Methyl methanesulfonate-sensitivity protein 19", "protein_names_refseq": "Met18p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL128W)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14562106;16273108;18836076;21177495;22678362;24374639;392238;8943333;9169870;9321645", "class_list": "", "function": "Key component of the cytosolic iron-sulfur protein assembly (CIA) machinery that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. Acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as RAD3/XPD and DNA2, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVF9;P89106;Q45U11", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40469-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40471-1", "uniprot_id": "AYR1_YEAST", "mass": 32814.0, "length": 297, "protein_name": "NADPH-dependent 1-acyldihydroxyacetone phosphate reductase", "gene_name": "AYR1", "organism": "Yeast", "refseq_name": "acylglycerone-phosphate reductase", "refseq_ac": "NP_012142", "gene_names_uniprotkb": "AYR1; GBG1", "gene_names_refseq": "AYR1; GBG1", "protein_names_uniprotkb": "NADPH-dependent 1-acyldihydroxyacetone phosphate reductase; 1-acyl DHAP reductase; 1.1.1.101; 3.1.1.3; ADR; Acyl/alkyl DHAP reductase; Acylglycerone-phosphate reductase; TAG lipase; Triacylglycerol lipase AYR1", "protein_names_refseq": "acylglycerone-phosphate reductase", "tax_id": 559292, "disease": "autosomal recessive congenital ichthyosis 13 (Disease Ontology:DOID:0080257)", "pathway": " (sce:YIL124W)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10515935;10617610;14562095;14562106;1512203;16407407;18407956;21820081;23956635;24187129;24374639;24868093;26162625;28916712;33491328;9169870", "class_list": "", "function": "Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA) (PubMed:10617610, PubMed:1512203). Also has triacylglycerol (TAG) lipase activity. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs (PubMed:24187129). Required for spore germination (PubMed:10617610). Plays a role in cell wall biogenesis, but this effect may be indirect by affecting the activities of cell wall synthesis enzymes (PubMed:23956635). Lipolysis of TAG by AYR1 is essential for starvation-induced autophagy (PubMed:26162625). Forms an NADPH-regulated cation-selective channel in the mitochondrial outer membrane (PubMed:28916712)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVG3", "ec_number_list": "3.1.1.3;1.1.1.101", "go_molecular_function": "GO:0004806 triacylglycerol lipase activity;GO:0000140 acylglycerone-phosphate reductase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P40471-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40472-1", "uniprot_id": "SIM1_YEAST", "mass": 48190.0, "length": 476, "protein_name": "Probable secreted beta-glucosidase SIM1", "gene_name": "SIM1", "organism": "Yeast", "refseq_name": "putative glucosidase SIM1", "refseq_ac": "NP_012143", "gene_names_uniprotkb": "SIM1; PBP3", "gene_names_refseq": "SIM1", "protein_names_uniprotkb": "Probable secreted beta-glucosidase SIM1; 3.2.1.-", "protein_names_refseq": "putative glucosidase SIM1", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL123W)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11958935;14562106;16273108;17244705;24040106;24374639;8574583;9169870", "class_list": "", "function": "Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions. Required for the maintenance of the CLB5 kinase activity., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2TBN1;D6VVG4;Q45U06;Q870H1", "ec_number_list": "", "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0009277 fungal-type cell wall", "go_biological_process": "GO:0000272 polysaccharide catabolic process;GO:0031505 fungal-type cell wall organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40472-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40477-1", "uniprot_id": "NU159_YEAST", "mass": 158908.0, "length": 1460, "protein_name": "Nucleoporin NUP159", "gene_name": "NUP159", "organism": "Yeast", "refseq_name": "FG-nucleoporin NUP159", "refseq_ac": "NP_012151", "gene_names_uniprotkb": "NUP159; NUP158; RAT7", "gene_names_refseq": "NUP158; NUP159; RAT7", "protein_names_uniprotkb": "Nucleoporin NUP159; Nuclear pore protein NUP159", "protein_names_refseq": "FG-nucleoporin NUP159", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL115C)", "pathway_count": 1, "publication_count": 46, "publication_id_list": "10523319;10684247;10801828;10952996;11387327;11689687;11739405;12543930;12604785;12791264;14562106;15039779;15574330;15665377;17287358;17330950;17546040;17563356;18407956;19684113;19779198;19795423;19823750;20190278;20489023;20702584;21126336;21177495;21930948;22213798;22218487;22480613;23223634;23749301;24374639;25646085;30516470;32597660;33229814;33481703;33491328;7744966;9169870;9736720;9843582;9891088", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP159 plays an important role in several nuclear export pathways including poly(A)+ RNA, pre-ribosome, and protein export., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 24, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 24, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 24, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 61, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 25, "binding_glycan_count": 0, "secondary_ac_list": "D6VVH2", "ec_number_list": "", "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0000774 adenyl-nucleotide exchange factor activity;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0044614 nuclear pore cytoplasmic filaments", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0000055 ribosomal large subunit export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0006611 protein export from nucleus;GO:0006607 NLS-bearing protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 7.2, "record_id": "P40477-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40479-1", "uniprot_id": "SDP1_YEAST", "mass": 23886.0, "length": 209, "protein_name": "Dual-specificity protein phosphatase SDP1", "gene_name": "SDP1", "organism": "Yeast", "refseq_name": "mitogen-activated protein kinase tyrosine protein phosphatase SDP1", "refseq_ac": "NP_012153", "gene_names_uniprotkb": "SDP1", "gene_names_refseq": "SDP1", "protein_names_uniprotkb": "Dual-specificity protein phosphatase SDP1; 3.1.3.48; Stress-inducible MAPK phosphatase", "protein_names_refseq": "mitogen-activated protein kinase tyrosine protein phosphatase SDP1", "tax_id": 559292, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); pulmonary tuberculosis (Disease Ontology:DOID:2957); carcinoma (Disease Ontology:DOID:305); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (sce:YIL113W); (R-SCE-202670)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12220658;17330950;17495930;20489023;24374639;32597660;33481703;33491328;9169870", "class_list": "", "function": "Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVH4", "ec_number_list": "3.1.3.48;3.1.3.16;3.1.3.2;2.7.11.24", "go_molecular_function": "GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000196 cell integrity MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P40479-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40480-1", "uniprot_id": "HOS4_YEAST", "mass": 123556.0, "length": 1083, "protein_name": "Protein HOS4", "gene_name": "HOS4", "organism": "Yeast", "refseq_name": "Hos4p", "refseq_ac": "NP_012154", "gene_names_uniprotkb": "HOS4", "gene_names_refseq": "HOS4", "protein_names_uniprotkb": "Protein HOS4", "protein_names_refseq": "Hos4p", "tax_id": 559292, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); intellectual disability (Disease Ontology:DOID:1059); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); epilepsy (Disease Ontology:DOID:1826); uremia (Disease Ontology:DOID:4676); proteinuria (Disease Ontology:DOID:576)", "pathway": " (sce:YIL112W); (R-SCE-204005); (R-SCE-3295583); (R-SCE-983168)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "11711434;15665377;17330950;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22814378;23749301;24374639;30516470;32597660;33481703;33491328;9169870", "class_list": "", "function": "Unknown. Component of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 46, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVH5", "ec_number_list": "", "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0034967 Set3 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006974 DNA damage response;GO:0009267 cellular response to starvation;GO:0045835 negative regulation of meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P40480-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40485-1", "uniprot_id": "SLM1_YEAST", "mass": 77995.0, "length": 686, "protein_name": "Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1", "gene_name": "SLM1", "organism": "Yeast", "refseq_name": "phosphatidylinositol 4,5-bisphosphate-binding protein", "refseq_ac": "NP_012161", "gene_names_uniprotkb": "SLM1; LIT2", "gene_names_refseq": "LIT2; SLM1", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1; Synthetic lethal with MSS4 protein 1; TORC2 effector protein SLM1", "protein_names_refseq": "phosphatidylinositol 4,5-bisphosphate-binding protein", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL105C)", "pathway_count": 1, "publication_count": 24, "publication_id_list": "14562106;15023338;15372071;15689497;16738335;16959779;17101780;17563356;18407956;19684113;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;32597660;33481703;33491328;34492164;9169870", "class_list": "", "function": "Together with SLM2, acts as an effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. May play a role in the response to the disruption of sphingolipid synthesis, where dephosphorylation of SLM1 leads to the activation and phosphorylation of YPK1 through the TORC2 and PKH1 pathways, which in turn phosphorylates ORM1 and LAG1 to activate sphingolipid synthesis (PubMed:34492164). Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis (PubMed:16738335)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVI2", "ec_number_list": "", "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0046625 sphingolipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006665 sphingolipid metabolic process;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P40485-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40495-1", "uniprot_id": "LYS12_YEAST", "mass": 40069.0, "length": 371, "protein_name": "Homoisocitrate dehydrogenase, mitochondrial", "gene_name": "LYS12", "organism": "Yeast", "refseq_name": "homoisocitrate dehydrogenase", "refseq_ac": "NP_012172", "gene_names_uniprotkb": "LYS12; LYS10; LYS11; YI9910.02C", "gene_names_refseq": "LYS10; LYS11; LYS12", "protein_names_uniprotkb": "Homoisocitrate dehydrogenase, mitochondrial; 1.1.1.87; HIcDH", "protein_names_refseq": "homoisocitrate dehydrogenase", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL094C)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "14562095;14562106;14576278;17223711;18407956;19530703;19684113;20702584;23749301;24374639;32597660;33481703;33491328;34965436;3939712;4284830;4395693;8962070;9169870", "class_list": "", "function": "Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVJ3", "ec_number_list": "1.1.1.87", "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0047046 homoisocitrate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0009085 lysine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P40495-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40501-1", "uniprot_id": "AVT7_YEAST", "mass": 53737.0, "length": 490, "protein_name": "Vacuolar amino acid transporter 7", "gene_name": "AVT7", "organism": "Yeast", "refseq_name": "Avt7p", "refseq_ac": "NP_012178", "gene_names_uniprotkb": "AVT7", "gene_names_refseq": "AVT7", "protein_names_uniprotkb": "Vacuolar amino acid transporter 7", "protein_names_refseq": "Avt7p", "tax_id": 559292, "disease": "foveal hypoplasia 2 (Disease Ontology:DOID:0070531)", "pathway": " (sce:YIL088C)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11274162;14562106;16847258;24374639;33481703;33491328;9169870", "class_list": "", "function": "Probable amino acid transporter of unknown specificity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVJ9", "ec_number_list": "", "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity;GO:0005302 L-tyrosine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005774 vacuolar membrane;GO:0000329 fungal-type vacuole membrane;GO:0000324 fungal-type vacuole", "go_biological_process": "GO:0006865 amino acid transport;GO:0003333 amino acid transmembrane transport;GO:0043937 regulation of sporulation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40501-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40505-1", "uniprot_id": "SDS3_YEAST", "mass": 37625.0, "length": 327, "protein_name": "Transcriptional regulatory protein SDS3", "gene_name": "SDS3", "organism": "Yeast", "refseq_name": "Sds3p", "refseq_ac": "NP_012182", "gene_names_uniprotkb": "SDS3", "gene_names_refseq": "SDS3", "protein_names_uniprotkb": "Transcriptional regulatory protein SDS3; Suppressor of defective silencing protein 3", "protein_names_refseq": "Sds3p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL084C); (R-SCE-3214815)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10655212;11024051;11405640;12672825;14562095;14562106;16286008;16314178;17322287;17563356;18407956;19779198;20702584;21177495;22814378;23749301;24374639;30516470;32597660;33229814;33481703;33491328;8978024;9169870", "class_list": "", "function": "Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D6VVK2", "ec_number_list": "", "go_molecular_function": "GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070822 Sin3-type complex;GO:0070210 Rpd3L-Expanded complex;GO:0033698 Rpd3L complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P40505-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40507-1", "uniprot_id": "AIR1_YEAST", "mass": 41631.0, "length": 360, "protein_name": "Protein AIR1", "gene_name": "AIR1", "organism": "Yeast", "refseq_name": "TRAMP complex RNA-binding subunit", "refseq_ac": "NP_012186", "gene_names_uniprotkb": "AIR1", "gene_names_refseq": "AIR1", "protein_names_uniprotkb": "Protein AIR1; Arginine methyltransferase-interacting RING finger protein 1", "protein_names_refseq": "TRAMP complex RNA-binding subunit", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL079C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10896665;14562095;14562106;15828860;15935759;16374505;18407956;19795423;19823750;20702584;21177495;22218487;24374639;24909858;33481703;33491328;9169870", "class_list": "", "function": "Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. AIR1 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVK5", "ec_number_list": "", "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0031499 TRAMP complex", "go_biological_process": "GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038 TRAMP-dependent tRNA surveillance pathway;GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process;GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process;GO:0071039 nuclear polyadenylation-dependent CUT catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P40507-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40509-1", "uniprot_id": "COPE_YEAST", "mass": 33829.0, "length": 296, "protein_name": "Coatomer subunit epsilon", "gene_name": "SEC28", "organism": "Yeast", "refseq_name": "coatomer subunit epsilon", "refseq_ac": "NP_012189", "gene_names_uniprotkb": "SEC28", "gene_names_refseq": "ANU2; SEC28", "protein_names_uniprotkb": "Coatomer subunit epsilon; Epsilon-COP; Epsilon-coat protein", "protein_names_refseq": "coatomer subunit epsilon", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL076W); (R-SCE-6807878); (R-SCE-6811434)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14562095;14562106;15905473;17101773;24374639;9169870;9463377", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVK8", "ec_number_list": "", "go_molecular_function": "GO:0005198 structural molecule activity;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P40509-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40510-1", "uniprot_id": "SER33_YEAST", "mass": 51188.0, "length": 469, "protein_name": "D-3-phosphoglycerate dehydrogenase 2", "gene_name": "SER33", "organism": "Yeast", "refseq_name": "phosphoglycerate dehydrogenase SER33", "refseq_ac": "NP_012191", "gene_names_uniprotkb": "SER33", "gene_names_refseq": "SER33", "protein_names_uniprotkb": "D-3-phosphoglycerate dehydrogenase 2; 1.1.1.399; 1.1.1.95; 2-oxoglutarate reductase; 3-PGDH 2", "protein_names_refseq": "phosphoglycerate dehydrogenase SER33", "tax_id": 559292, "disease": "PHGDH deficiency (Disease Ontology:DOID:0050722); Neu-Laxova syndrome 1 (Disease Ontology:DOID:0080076); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (sce:YIL074C)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "14562106;15665377;17330950;18407956;19779198;20702584;21126336;21177495;22218487;22814378;23749301;24374639;26774271;32597660;33481703;33491328;9169870", "class_list": "", "function": "Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVL0", "ec_number_list": "1.1.1.399;1.1.1.95", "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0004617 phosphoglycerate dehydrogenase activity;GO:0047545 (S)-2-hydroxyglutarate dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006066 alcohol metabolic process;GO:0040029 epigenetic regulation of gene expression;GO:0006564 L-serine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P40510-1", "record_type": "protein" }, { "uniprot_canonical_ac": "P40517-1", "uniprot_id": "YRB2_YEAST", "mass": 36054.0, "length": 327, "protein_name": "Ran-specific GTPase-activating protein 2", "gene_name": "YRB2", "organism": "Yeast", "refseq_name": "Yrb2p", "refseq_ac": "NP_012201", "gene_names_uniprotkb": "YRB2", "gene_names_refseq": "YRB2", "protein_names_uniprotkb": "Ran-specific GTPase-activating protein 2; RANBP2; Ran-binding protein 2", "protein_names_refseq": "Yrb2p", "tax_id": 559292, "disease": "", "pathway": " (sce:YIL063C)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "14562106;17322287;17330950;17563356;18407956;19779198;19795423;19823750;20702584;21126336;21177495;22218487;23749301;24374639;24909858;32597660;33481703;33491328;9169870;9395535;9636166", "class_list": "", "function": "Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6VVM1", "ec_number_list": "", "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005829 cytosol", "go_biological_process": "GO:0006611 protein export from nucleus;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P40517-1", "record_type": "protein" } ]